suramin has been researched along with Necrosis in 10 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin- and saline-treated (control) mdx mice performed exercise on a treadmill to worsen disease progression." | 5.37 | Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-β1 blocker. ( Marques, MJ; Matsumura, CY; Pertille, A; Santo Neto, H; Taniguti, AP, 2011) |
| "Suramin- and saline-treated (control) mdx mice performed exercise on a treadmill to worsen disease progression." | 1.37 | Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-β1 blocker. ( Marques, MJ; Matsumura, CY; Pertille, A; Santo Neto, H; Taniguti, AP, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chaves-Moreira, D | 1 |
| de Moraes, FR | 1 |
| Caruso, ÍP | 1 |
| Chaim, OM | 1 |
| Senff-Ribeiro, A | 1 |
| Ullah, A | 1 |
| da Silva, LS | 1 |
| Chahine, J | 1 |
| Arni, RK | 2 |
| Veiga, SS | 1 |
| Taniguti, AP | 1 |
| Pertille, A | 1 |
| Matsumura, CY | 1 |
| Santo Neto, H | 1 |
| Marques, MJ | 1 |
| de Oliveira, M | 1 |
| Cavalcante, WL | 1 |
| Arruda, EZ | 2 |
| Melo, PA | 2 |
| Dal-Pai Silva, M | 1 |
| Gallacci, M | 1 |
| Uspenskaya, YA | 1 |
| Mikhutkina, SV | 1 |
| Taksanova, EI | 1 |
| Popova, NN | 1 |
| Olovyannikova, RY | 1 |
| Salmina, AB | 1 |
| Xiang, Z | 1 |
| Chen, M | 1 |
| Ping, J | 1 |
| Dunn, P | 1 |
| Lv, J | 1 |
| Jiao, B | 1 |
| Burnstock, G | 1 |
| Murakami, MT | 1 |
| Viçoti, MM | 1 |
| Abrego, JR | 1 |
| Lourenzoni, MR | 1 |
| Cintra, AC | 1 |
| Tomaz, MA | 1 |
| Wartenberg, M | 1 |
| Günther, J | 1 |
| Hescheler, J | 1 |
| Sauer, H | 1 |
| Chan, CF | 1 |
| Lin-Shiau, SY | 1 |
| Moore, AC | 1 |
| Ryan, ET | 1 |
| Waldron, MA | 1 |
| Tuchmann-Duplessis, H | 1 |
| Mercier-Parot, L | 1 |
10 other studies available for suramin and Necrosis
| Article | Year |
|---|---|
Potential Implications for Designing Drugs Against the Brown Spider Venom Phospholipase-D.
Topics: Animals; Arthropod Proteins; Benzimidazoles; Brown Recluse Spider; Drug Design; Drug Evaluation, Pre | 2017 |
Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-β1 blocker.
Topics: Animals; Creatine Kinase; Disease Models, Animal; Female; Fibrosis; Male; Mice; Mice, Inbred C57BL; | 2011 |
Antagonism of myotoxic and paralyzing activities of bothropstoxin-I by suramin.
Topics: Animals; Antivenins; Crotalid Venoms; Drug Antagonism; In Vitro Techniques; Male; Mice; Muscle, Skel | 2003 |
Induction of apoptosis in bone marrow cells is mediated via purinergic receptors.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Bone Marrow Cells; Doxorubicin; Male; Mice; Necrosis; Py | 2004 |
Microglial morphology and its transformation after challenge by extracellular ATP in vitro.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Line; Cell Size; Flow Cytometry; Fluorescein-5-isot | 2006 |
Interfacial surface charge and free accessibility to the PLA2-active site-like region are essential requirements for the activity of Lys49 PLA2 homologues.
Topics: Animals; Binding Sites; Bothrops; Creatine Kinase; Crotalid Venoms; Crystallization; Dose-Response R | 2007 |
The embryoid body as a novel in vitro assay system for antiangiogenic agents.
Topics: Animals; Capillaries; Cell Culture Techniques; Cell Differentiation; Cells, Cultured; Doxorubicin; E | 1998 |
Site of action of suramin and reactive blue 2 in preventing neuronal death induced by dequalinium.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Cell Survival; Cells, Cultured; C | 2000 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 20-2002. A 37-year-old man with fever, hepatosplenomegaly, and a cutaneous foot lesion after a trip to Africa.
Topics: Adult; Africa; Animals; Anthrax; Blood; Cerebrospinal Fluid; Diagnosis, Differential; Erythema; Feve | 2002 |
[Effect of suramine on perinatal and postnatal survival in mice].
Topics: Abnormalities, Drug-Induced; Abortifacient Agents; Animals; Animals, Newborn; Female; Fetus; Gestati | 1973 |