Page last updated: 2024-08-07 15:24:44
Polyphenol oxidase 2
[no definition available]
Synonyms
PPO2;
Phenolase 2;
EC 1.14.18.1;
Cresolase 2;
Tyrosinase 2
Research
Bioassay Publications (130)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (1.54) | 18.2507 |
| 2000's | 32 (24.62) | 29.6817 |
| 2010's | 93 (71.54) | 24.3611 |
| 2020's | 3 (2.31) | 2.80 |
Compounds (183)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| protocatechuic acid | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| 3-phenylpropionic acid | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| 4-hydroxybenzyl alcohol | Agaricus bisporus | IC50 | 666.6167 | 2 | 3 |
| 4-hydroxybenzaldehyde | Agaricus bisporus | IC50 | 1,082.5000 | 4 | 4 |
| 4-hydroxybenzoic acid | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| benzaldehyde | Agaricus bisporus | IC50 | 177.0000 | 1 | 1 |
| benzoic acid | Agaricus bisporus | IC50 | 425.3220 | 5 | 5 |
| cuminaldehyde | Agaricus bisporus | IC50 | 75.0000 | 1 | 1 |
| salicylic acid | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| hydroquinone | Agaricus bisporus | IC50 | 1,477.9692 | 12 | 13 |
| acetanilide | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| niacin | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| 4-aminobenzoic acid | Agaricus bisporus | IC50 | 3.8000 | 1 | 1 |
| vanillin | Agaricus bisporus | IC50 | 4,103.0000 | 1 | 1 |
| 4-hydroxybenzoic acid hydrazide | Agaricus bisporus | Ki | 177.2000 | 1 | 1 |
| hexylresorcinol | Agaricus bisporus | IC50 | 0.7167 | 3 | 3 |
| beta-thujaplicin | Agaricus bisporus | IC50 | 0.0900 | 3 | 3 |
| beta-thujaplicin | Agaricus bisporus | Ki | 0.0600 | 1 | 1 |
| isoniazid | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| kojic acid | Agaricus bisporus | IC50 | 63.2557 | 107 | 108 |
| kojic acid | Agaricus bisporus | Ki | 82.3278 | 9 | 9 |
| resorcinol | Agaricus bisporus | IC50 | 1,072.3333 | 3 | 3 |
| n-phenylurea | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| barbituric acid | Agaricus bisporus | IC50 | 200.0000 | 1 | 1 |
| 2-acetylthiophene | Agaricus bisporus | IC50 | 150.0000 | 1 | 1 |
| thymol | Agaricus bisporus | IC50 | 3,212.5000 | 2 | 2 |
| salicylaldehyde | Agaricus bisporus | IC50 | 916.5000 | 2 | 2 |
| veratric acid | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| 2,4-dihydroxybenzaldehyde | Agaricus bisporus | IC50 | 200.0000 | 1 | 1 |
| furaldehyde | Agaricus bisporus | IC50 | 43.0000 | 1 | 1 |
| acetophenone | Agaricus bisporus | IC50 | 850.0000 | 1 | 1 |
| 4-acetylanisole | Agaricus bisporus | IC50 | 2,000.0000 | 1 | 1 |
| 4-anisic acid | Agaricus bisporus | IC50 | 260.0000 | 2 | 2 |
| 4-methylbenzaldehyde | Agaricus bisporus | IC50 | 120.0000 | 1 | 1 |
| 2'-hydroxyacetophenone | Agaricus bisporus | IC50 | 300.0000 | 1 | 1 |
| vanillic acid | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| potassium cyanide | Agaricus bisporus | IC50 | 24.0000 | 1 | 1 |
| carvacrol | Agaricus bisporus | IC50 | 500.0000 | 1 | 1 |
| 3-pyridinaldehyde | Agaricus bisporus | IC50 | 28.0000 | 1 | 1 |
| 2-methylbenzaldehyde | Agaricus bisporus | Ki | 1,853.0000 | 1 | 1 |
| syringic acid | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| tropolone | Agaricus bisporus | IC50 | 0.4000 | 5 | 5 |
| paeonol | Agaricus bisporus | IC50 | 121.4000 | 1 | 1 |
| 2-methylresorcinol | Agaricus bisporus | IC50 | 1,066.0000 | 2 | 2 |
| 3-methylbenzaldehyde | Agaricus bisporus | Ki | 290.0000 | 1 | 1 |
| isovanillin | Agaricus bisporus | IC50 | 500.0000 | 1 | 1 |
| isovanillic acid | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| gamma-thujaplicin | Agaricus bisporus | IC50 | 0.0700 | 3 | 3 |
| gamma-thujaplicin | Agaricus bisporus | Ki | 0.0200 | 1 | 1 |
| biphenyl-3-carboxylic acid | Agaricus bisporus | IC50 | 21.6450 | 2 | 2 |
| zingerone | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid | Agaricus bisporus | IC50 | 200.0000 | 1 | 1 |
| bergenin | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| 4-phenylbenzoic acid | Agaricus bisporus | IC50 | 139.6450 | 2 | 2 |
| sesamol | Agaricus bisporus | IC50 | 6.7000 | 1 | 1 |
| 2,6-dihydroxyacetophenone | Agaricus bisporus | IC50 | 300.0000 | 1 | 1 |
| biphenyl-2-carboxylic acid | Agaricus bisporus | IC50 | 1,000.0000 | 2 | 2 |
| pinobanksin | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| 4-chlorosalicylic acid | Agaricus bisporus | IC50 | 520.0000 | 1 | 1 |
| 6-chloronicotinic acid | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| alpha-thujaplicin | Agaricus bisporus | IC50 | 9.5300 | 3 | 3 |
| alpha-thujaplicin | Agaricus bisporus | Ki | 3.3000 | 1 | 1 |
| 3-(2,4-dihydroxyphenyl)propionic acid | Agaricus bisporus | IC50 | 1.8500 | 1 | 1 |
| thiacloprid | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| aromadedrin | Agaricus bisporus | IC50 | 124.5333 | 3 | 3 |
| aromadedrin | Agaricus bisporus | Ki | 42.0000 | 1 | 1 |
| salicylideneaniline | Agaricus bisporus | IC50 | 250.0000 | 1 | 1 |
| moracin c | Agaricus bisporus | IC50 | 2.2700 | 1 | 1 |
| scorpions | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| 4-n-butylresorcinol | Agaricus bisporus | IC50 | 0.1500 | 1 | 1 |
| prizes | Agaricus bisporus | IC50 | 1,740.0000 | 1 | 1 |
| 1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone | Agaricus bisporus | IC50 | 140.2333 | 3 | 3 |
| n-methylcorydaldine | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| taxifolin | Agaricus bisporus | IC50 | 25.0000 | 2 | 2 |
| taxifolin | Agaricus bisporus | Ki | 21.5000 | 2 | 2 |
| mimosine | Agaricus bisporus | IC50 | 3.6800 | 3 | 3 |
| arbutin | Agaricus bisporus | IC50 | 5,993.4176 | 17 | 17 |
| silychristin | Agaricus bisporus | IC50 | 16.0000 | 2 | 2 |
| silychristin | Agaricus bisporus | Ki | 8.7000 | 4 | 4 |
| syringaresinol | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| e-z cinnamic acid | Agaricus bisporus | IC50 | 323.1667 | 3 | 3 |
| resveratrol | Agaricus bisporus | IC50 | 45.9500 | 3 | 3 |
| ferulic acid | Agaricus bisporus | IC50 | 350.0000 | 1 | 1 |
| cinnamaldehyde | Agaricus bisporus | IC50 | 520.0000 | 1 | 1 |
| 2-hydroxycinnamic acid | Agaricus bisporus | IC50 | 670.0000 | 1 | 1 |
| trans-4-coumaric acid | Agaricus bisporus | IC50 | 2,414.9000 | 2 | 2 |
| sinapinic acid | Agaricus bisporus | IC50 | 351.0000 | 1 | 1 |
| 2,4,4'-trihydroxydeoxybenzoin | Agaricus bisporus | IC50 | 162.2600 | 3 | 3 |
| 2-methoxycinnamaldehyde | Agaricus bisporus | IC50 | 420.0000 | 1 | 1 |
| 4'-methoxychalcone | Agaricus bisporus | IC50 | 141.8000 | 1 | 1 |
| prothionamide | Agaricus bisporus | IC50 | 4.5000 | 1 | 1 |
| 2-mercaptonicotinic acid | Agaricus bisporus | IC50 | 80.0000 | 1 | 1 |
| phenylthiourea | Agaricus bisporus | IC50 | 1.5333 | 3 | 3 |
| phenylthiourea | Agaricus bisporus | Ki | 0.3000 | 1 | 1 |
| thiobenzamide | Agaricus bisporus | IC50 | 2.8000 | 1 | 1 |
| 2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-1-benzopyran-4-one | Agaricus bisporus | IC50 | 0.0700 | 1 | 1 |
| caffeic acid | Agaricus bisporus | IC50 | 350.0000 | 1 | 1 |
| 4-methoxycinnamic acid | Agaricus bisporus | IC50 | 401.4286 | 7 | 7 |
| diphenylthiourea | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| 3-(3,4-dimethoxyphenyl)propenoic acid | Agaricus bisporus | IC50 | 350.0000 | 1 | 1 |
| 4-amino-5-(pyridin-4-yl)-4h-1,2,4-triazole-3-thiol | Agaricus bisporus | Ki | 1.0100 | 1 | 1 |
| 5-phenyl-1,3,4-oxadiazole-2-thiol | Agaricus bisporus | Ki | 6.4700 | 1 | 1 |
| isoferulic acid | Agaricus bisporus | IC50 | 115.2000 | 1 | 1 |
| thionicotinamide | Agaricus bisporus | IC50 | 7.5000 | 1 | 1 |
| benzylthiourea | Agaricus bisporus | IC50 | 25.4000 | 1 | 1 |
| 6-mercapto-3-pyridinecarboxylic acid | Agaricus bisporus | IC50 | 42.0000 | 1 | 1 |
| thioacetanilide | Agaricus bisporus | IC50 | 4.1000 | 1 | 1 |
| thioacetanilide | Agaricus bisporus | Ki | 1.2000 | 1 | 1 |
| 2-mercaptoimidazole | Agaricus bisporus | IC50 | 4,110.0000 | 1 | 1 |
| 2-mercaptoimidazole | Agaricus bisporus | Ki | 570.0000 | 1 | 1 |
| (z)-5-(2'-hydroxybenzylidene)-2-thioxothiazolidin-4-one | Agaricus bisporus | IC50 | 9,550.0000 | 1 | 1 |
| methimazole | Agaricus bisporus | IC50 | 1,430.0000 | 1 | 1 |
| methimazole | Agaricus bisporus | Ki | 470.0000 | 1 | 1 |
| pyridine-2-carbothioamide | Agaricus bisporus | IC50 | 14.4000 | 1 | 1 |
| thiobarbituric acid | Agaricus bisporus | IC50 | 200.0000 | 1 | 1 |
| thiosemicarbazide | Agaricus bisporus | IC50 | 2,000.0000 | 1 | 1 |
| thiocarbohydrazide | Agaricus bisporus | IC50 | 178.3000 | 1 | 1 |
| ethionamide | Agaricus bisporus | IC50 | 4.0000 | 1 | 1 |
| dieckol | Agaricus bisporus | IC50 | 20.0000 | 1 | 1 |
| nitenpyram | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| silybin | Agaricus bisporus | IC50 | 6.9000 | 2 | 2 |
| silybin | Agaricus bisporus | Ki | 4.5750 | 4 | 4 |
| 3-hydroxy-2-methyl-4h-pyran-4-thione | Agaricus bisporus | IC50 | 3.8000 | 1 | 1 |
| quercetin | Agaricus bisporus | IC50 | 135.5000 | 2 | 2 |
| apigenin | Agaricus bisporus | IC50 | 305.0000 | 2 | 2 |
| quercitrin | Agaricus bisporus | IC50 | 125.0000 | 2 | 2 |
| coniferaldehyde | Agaricus bisporus | IC50 | 240.0000 | 1 | 1 |
| rutin | Agaricus bisporus | IC50 | 100.0000 | 2 | 2 |
| kaempferol | Agaricus bisporus | IC50 | 135.7000 | 2 | 2 |
| gardenia yellow | Agaricus bisporus | IC50 | 140.0000 | 1 | 1 |
| hispidol | Agaricus bisporus | IC50 | 38.4000 | 1 | 1 |
| 7-hydroxycoumarin | Agaricus bisporus | IC50 | 420.0000 | 1 | 1 |
| galangin | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| kaempferide | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| morusin | Agaricus bisporus | IC50 | 275.1500 | 1 | 2 |
| myricetin | Agaricus bisporus | IC50 | 210.0000 | 1 | 1 |
| myricitrin | Agaricus bisporus | IC50 | 220.0000 | 2 | 2 |
| trans-2,3',4,5'-tetrahydroxystilbene | Agaricus bisporus | Ki | 25.0000 | 2 | 2 |
| rosmarinic acid | Agaricus bisporus | IC50 | 250.0000 | 1 | 1 |
| ethisterone | Agaricus bisporus | IC50 | 2.6100 | 1 | 1 |
| cinnamyl alcohol | Agaricus bisporus | IC50 | 10,000.0000 | 1 | 1 |
| kaempferol 3-o-rhamnoside | Agaricus bisporus | IC50 | 400.0000 | 1 | 1 |
| (E)-3-(2-Hydroxyphenyl)-2-propenal | Agaricus bisporus | IC50 | 470.0000 | 1 | 1 |
| diferuloylputrescine | Agaricus bisporus | IC50 | 108.4000 | 1 | 1 |
| 3,5,4'-trihydroxystilbene-4'-o-glucoside | Agaricus bisporus | IC50 | 19.0000 | 1 | 1 |
| trilinolein | Agaricus bisporus | IC50 | 8.4000 | 1 | 1 |
| 3-(4-hydroxy-3-methoxyphenyl)-n-(2-(4-hydroxy-3-methoxyphenyl)ethyl)-2-propenamide | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| n-(4-hydroxy-beta-phenethyl)-4-hydroxycinnamide | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| 2',4'-dihydroxychalcone | Agaricus bisporus | IC50 | 110.2200 | 1 | 1 |
| 2-formylpyridine thiosemicarbazone | Agaricus bisporus | IC50 | 45.0000 | 1 | 1 |
| n-(p-coumaroyl)serotonin | Agaricus bisporus | IC50 | 8.8000 | 1 | 1 |
| 4,4'-dihydroxychalcone | Agaricus bisporus | IC50 | 4.8000 | 1 | 1 |
| 4,4'-dihydroxychalcone | Agaricus bisporus | Ki | 2.9000 | 1 | 1 |
| Norartocarpetin | Agaricus bisporus | IC50 | 167.0667 | 2 | 3 |
| Norartocarpetin | Agaricus bisporus | Ki | 0.0006 | 1 | 1 |
| thiamethoxam | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| lespenefril | Agaricus bisporus | IC50 | 400.0000 | 1 | 1 |
| n-feruloylserotonin | Agaricus bisporus | IC50 | 8.0000 | 1 | 1 |
| 2',4',6'-trihydroxychalcone | Agaricus bisporus | IC50 | 120.0000 | 1 | 1 |
| 4-isopropylbenzaldehyde thiosemicarbazone | Agaricus bisporus | IC50 | 2.8300 | 1 | 1 |
| 3-hydroxy-4-methoxybenzaldehyde thiosemicarbazone | Agaricus bisporus | IC50 | 4.8800 | 1 | 1 |
| 2-(quinolin-2-ylmethylene)hydrazinecarbothioamide | Agaricus bisporus | IC50 | 70.0000 | 1 | 1 |
| cinnamaldehyde thiosemicarbazone | Agaricus bisporus | Ki | 4.4500 | 1 | 1 |
| helicide | Agaricus bisporus | IC50 | 940.0000 | 2 | 2 |
| sri 224 | Agaricus bisporus | IC50 | 0.1100 | 1 | 1 |
| 2,4,2',4'-Tetrahydroxychalcone | Agaricus bisporus | IC50 | 5.0000 | 2 | 2 |
| 6-(3-hydroxyphenyl)-2-naphthol | Agaricus bisporus | IC50 | 6.4000 | 1 | 1 |
| lupinifolin | Agaricus bisporus | IC50 | 47.6500 | 2 | 2 |
| lupinifolin | Agaricus bisporus | Ki | 20.8150 | 2 | 2 |
| isosilybin b | Agaricus bisporus | IC50 | 12.3500 | 2 | 2 |
| isosilybin b | Agaricus bisporus | Ki | 8.2000 | 4 | 4 |
| isosilybin a | Agaricus bisporus | IC50 | 9.4000 | 2 | 2 |
| isosilybin a | Agaricus bisporus | Ki | 6.7250 | 4 | 4 |
| 6-methyl-3-phenethyl-3,4-dihydro-1h-quinazoline-2-thione | Agaricus bisporus | IC50 | 100.0000 | 1 | 1 |
| helicide | Agaricus bisporus | IC50 | 2,540.0000 | 1 | 1 |
| Moracin P | Agaricus bisporus | IC50 | 2.9000 | 1 | 1 |
| 4-dodecylaminophenol | Agaricus bisporus | IC50 | 200.0000 | 2 | 2 |
| hs 1793 | Agaricus bisporus | IC50 | 0.0340 | 1 | 1 |
| Norartocarpanone | Agaricus bisporus | IC50 | 18.1000 | 3 | 3 |
| sodium bisulfite | Agaricus bisporus | IC50 | 210.0000 | 1 | 1 |
| p-decylaminophenol | Agaricus bisporus | IC50 | 17.9000 | 2 | 2 |
| ascorbic acid | Agaricus bisporus | IC50 | 264.2500 | 4 | 4 |
| 5-adamantan-1-yl-n-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide | Agaricus bisporus | IC50 | 0.9000 | 1 | 1 |
| imidacloprid | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| clothianidin | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| allopurinol | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| salicylaldehyde thiosemicarbazone | Agaricus bisporus | IC50 | 0.3800 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| methoxsalen | Agaricus bisporus | EC50 | 14.8000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 4-hydroxybenzoic acid | Agaricus bisporus | ID50 | 1,900.0000 | 1 | 1 |
| salicylic acid | Agaricus bisporus | ID50 | 3,900.0000 | 1 | 1 |
| hydroquinone | Agaricus bisporus | Km | 920.0000 | 1 | 1 |
| phenol | Agaricus bisporus | Km | 700.0000 | 1 | 1 |
| beta-thujaplicin | Agaricus bisporus | Km | 845.0000 | 2 | 2 |
| resorcinol | Agaricus bisporus | ID50 | 1,200.0000 | 1 | 1 |
| resorcinol | Agaricus bisporus | Km | 460.0000 | 1 | 1 |
| tyramine | Agaricus bisporus | Km | 540.0000 | 1 | 1 |
| levodopa | Agaricus bisporus | Km | 860.0000 | 1 | 1 |
| tyrosine | Agaricus bisporus | Km | 230.0000 | 2 | 2 |
| mequinol | Agaricus bisporus | Km | 63.3800 | 2 | 2 |
| 2-methylresorcinol | Agaricus bisporus | Km | 2,700.0000 | 1 | 1 |
| 4-Ethoxyphenol | Agaricus bisporus | Km | 170.0000 | 1 | 1 |
| gamma-thujaplicin | Agaricus bisporus | Km | 740.0000 | 2 | 2 |
| 1-hydroxy-2(1h)-pyridinone | Agaricus bisporus | Kic | 1.8000 | 1 | 1 |
| alpha-thujaplicin | Agaricus bisporus | Km | 380.0000 | 2 | 2 |
| arbutin | Agaricus bisporus | ID50 | 6,200.0000 | 1 | 1 |
| silychristin | Agaricus bisporus | Kis | 20.1000 | 2 | 2 |
| prothionamide | Agaricus bisporus | Kic | 2.4000 | 1 | 1 |
| thiobenzamide | Agaricus bisporus | Kic | 0.7000 | 1 | 1 |
| thionicotinamide | Agaricus bisporus | Kic | 4.3000 | 1 | 1 |
| 2-mercaptoimidazole | Agaricus bisporus | Kis | 2,800.0000 | 1 | 1 |
| methimazole | Agaricus bisporus | Kis | 1,910.0000 | 1 | 1 |
| pyridine-2-carbothioamide | Agaricus bisporus | Kic | 2.7000 | 1 | 1 |
| ethionamide | Agaricus bisporus | Kic | 1.9000 | 1 | 1 |
| silybin | Agaricus bisporus | Kis | 15.6500 | 2 | 2 |
| quercetin | Agaricus bisporus | ID50 | 70.0000 | 1 | 1 |
| bilobol | Agaricus bisporus | ID50 | 80.0000 | 1 | 1 |
| ginkgolic acid | Agaricus bisporus | ID50 | 7,500.0000 | 1 | 1 |
| cinnamaldehyde thiosemicarbazone | Agaricus bisporus | Kis | 8.8500 | 1 | 1 |
| 2-hydroxy-6-[(8Z,11Z)-pentadeca-8,11,14-trien-1-yl]benzoic acid | Agaricus bisporus | ID50 | 2,650.0000 | 1 | 2 |
| isosilybin b | Agaricus bisporus | Kis | 16.6000 | 2 | 2 |
| isosilybin a | Agaricus bisporus | Kis | 16.3500 | 2 | 2 |
| 5-(pentadeca-8,11,14-trien-1-yl)resorcinol | Agaricus bisporus | ID50 | 40.0000 | 1 | 1 |
| agrimoniin | Agaricus bisporus | ID50 | 61.0000 | 1 | 1 |
Gusanlungionosides A-D, potential tyrosinase inhibitors from Arcangelisia gusanlung.Journal of natural products, , May-27, Volume: 74, Issue:5, 2011
Effects of hydroxybenzyl alcohols on melanogenesis in melanocyte-keratinocyte co-culture and monolayer culture of melanocytes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 23, Issue:4, 2008
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.Journal of agricultural and food chemistry, , May-11, Volume: 59, Issue:9, 2011
Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors.European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010
Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities.European journal of medicinal chemistry, , Volume: 44, Issue:10, 2009
Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Synthesis, antioxidant capacity, and structure-activity relationships of tri-O-methylnorbergenin analogues on tyrosinase inhibition.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Tyrosinase inhibitors from Bolivian medicinal plants.Journal of natural products, , Volume: 58, Issue:5, 1995
Discovery of a new type of scaffold for the creation of novel tyrosinase inhibitors.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Synthesis, antioxidant capacity, and structure-activity relationships of tri-O-methylnorbergenin analogues on tyrosinase inhibition.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.Journal of agricultural and food chemistry, , May-11, Volume: 59, Issue:9, 2011
Characterization of the action of tyrosinase on resorcinols.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 22, Issue:12, 2012
Tyrosinase inhibitory activity of a 6-isoprenoid-substituted flavanone isolated from Dalea elegans.Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
A newly synthesized, potent tyrosinase inhibitor: 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 20, Issue:16, 2010
Tyrosinase-inhibitory constituents from the twigs of Cinnamomum cassia.Journal of natural products, , Volume: 72, Issue:6, 2009
Studies on depigmenting activities of dihydroxyl benzamide derivatives containing adamantane moiety.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Effects of hydroxybenzyl alcohols on melanogenesis in melanocyte-keratinocyte co-culture and monolayer culture of melanocytes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 23, Issue:4, 2008
Pyronane monoterpenoids from the fruit of Gardenia jasminoides.Journal of natural products, , Volume: 71, Issue:6, 2008
Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 17, Issue:2, 2007
Antityrosinase principles and constituents of the petals of Crocus sativus.Journal of natural products, , Volume: 67, Issue:3, 2004
Constituents of the stigmas of Crocus sativus and their tyrosinase inhibitory activity.Journal of natural products, , Volume: 65, Issue:10, 2002
New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.Bioorganic & medicinal chemistry, , Jun-01, Volume: 18, Issue:11, 2010
Resorcinol alkyl glucosides as potent tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , 01-15, Volume: 29, Issue:2, 2019
Chemical synthesis and tyrosinase inhibitory activity of rhododendrol glycosides.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 24, Issue:1, 2014
PEG-immobilization of cardol and soluble polymer-supported synthesis of some cardol-coumarin derivatives: preliminary evaluation of their inhibitory activity on mushroom tyrosinase.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 19, Issue:1, 2009
Inhibitors of Melanogenesis: An Updated Review.Journal of medicinal chemistry, , 09-13, Volume: 61, Issue:17, 2018
Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
Novel 1,3,4-oxadiazole compounds inhibit the tyrosinase and melanin level: Synthesis, in-vitro, and in-silico studies.Bioorganic & medicinal chemistry, , 07-01, Volume: 41, 2021
Hydroxyl substituted benzoic acid/cinnamic acid derivatives: Tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 30, Issue:1, 2020
Kojic acid-natural product conjugates as mushroom tyrosinase inhibitors.European journal of medicinal chemistry, , Sep-01, Volume: 201, 2020
[no title available]European journal of medicinal chemistry, , Aug-01, Volume: 175, 2019
Synthesis and tyrosinase inhibitory activities of 4-oxobutanoate derivatives of carvacrol and thymol.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 29, Issue:1, 2019
Concise Modular Synthesis of Thalassotalic Acids A-C.Journal of natural products, , 04-26, Volume: 82, Issue:4, 2019
Veratric acid derivatives containing benzylidene-hydrazine moieties as promising tyrosinase inhibitors and free radical scavengers.Bioorganic & medicinal chemistry, , 06-15, Volume: 27, Issue:12, 2019
Thiosemicarbazones with tyrosinase inhibitory activity.MedChemComm, , Mar-01, Volume: 10, Issue:3, 2019
Resorcinol alkyl glucosides as potent tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , 01-15, Volume: 29, Issue:2, 2019
Melanogenic inhibitory effects of Triangularin in B16F0 melanoma cells, in vitro and molecular docking studies.Bioorganic & medicinal chemistry, , 08-15, Volume: 27, Issue:16, 2019
Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle).Bioorganic & medicinal chemistry, , 06-15, Volume: 27, Issue:12, 2019
Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile.European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.Bioorganic & medicinal chemistry, , 07-30, Volume: 26, Issue:13, 2018
Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments.Journal of medicinal chemistry, , 05-10, Volume: 61, Issue:9, 2018
Current progress on antioxidants incorporating the pyrazole core.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
Design, synthesis and evaluation of cinnamic acid ester derivatives as mushroom tyrosinase inhibitors.MedChemComm, , May-01, Volume: 9, Issue:5, 2018
The tyrosinase inhibitory effects of isoxazolone derivatives with a (Z)-β-phenyl-α, β-unsaturated carbonyl scaffold.Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Isolation of Flavonoids and Flavonoid Glycosides from Myrsine africana and Their Inhibitory Activities against Mushroom Tyrosinase.Journal of natural products, , 01-26, Volume: 81, Issue:1, 2018
Inhibitors of Melanogenesis: An Updated Review.Journal of medicinal chemistry, , 09-13, Volume: 61, Issue:17, 2018
Design, synthesis, kinetic mechanism and molecular docking studies of novel 1-pentanoyl-3-arylthioureas as inhibitors of mushroom tyrosinase and free radical scavengers.European journal of medicinal chemistry, , Dec-01, Volume: 141, 2017
Recent advances (2015-2016) in anticancer hybrids.European journal of medicinal chemistry, , Dec-15, Volume: 142, 2017
Study on the design, synthesis and structure-activity relationships of new thiosemicarbazone compounds as tyrosinase inhibitors.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Synthesis and biological evaluation of novel hydroxybenzaldehyde-based kojic acid analogues as inhibitors of mushroom tyrosinase.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Identification of six new lupane-type triterpenoids from Acanthopanax koreanum leaves and their tyrosinase inhibitory activities.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
Highly potent tyrosinase inhibitor, neorauflavane from Campylotropis hirtella and inhibitory mechanism with molecular docking.Bioorganic & medicinal chemistry, , Jan-15, Volume: 24, Issue:2, 2016
N-Acyl Dehydrotyrosines, Tyrosinase Inhibitors from the Marine Bacterium Thalassotalea sp. PP2-459.Journal of natural products, , Feb-26, Volume: 79, Issue:2, 2016
Design and synthesis of thiourea derivatives with sulfur-containing heterocyclic scaffolds as potential tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Apr-15, Volume: 24, Issue:8, 2016
Design and synthesis of novel hydroxypyridinone derivatives as potential tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , 07-01, Volume: 26, Issue:13, 2016
One-pot green synthesis of 1,3,5-triarylpentane-1,5-dione and triarylmethane derivatives as a new class of tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
Structure-based modification of 3-/4-aminoacetophenones giving a profound change of activity on tyrosinase: from potent activators to highly efficient inhibitors.European journal of medicinal chemistry, , Mar-26, Volume: 93, 2015
Inhibitors of melanogenesis in B16 melanoma 4A5 cells from flower buds of Lawsonia inermis (Henna).Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 25, Issue:13, 2015
Rational design, synthesis and structure-activity relationships of 4-alkoxy- and 4-acyloxy-phenylethylenethiosemicarbazone analogues as novel tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Mar-01, Volume: 23, Issue:5, 2015
Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 25, Issue:4, 2015
Design and synthesis of aloe-emodin derivatives as potent anti-tyrosinase, antibacterial and anti-inflammatory agents.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 25, Issue:22, 2015
Synthesis of novel compounds containing morpholine and 5(4H)-oxazolone rings as potent tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Nov-01, Volume: 23, Issue:21, 2015
Synthesis, kinetic mechanism and docking studies of vanillin derivatives as inhibitors of mushroom tyrosinase.Bioorganic & medicinal chemistry, , Sep-01, Volume: 23, Issue:17, 2015
Integrated kinetic studies and computational analysis on naphthyl chalcones as mushroom tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 25, Issue:19, 2015
Inhibitory kinetics of novel 2,3-dihydro-1H-inden-1-one chalcone-like derivatives on mushroom tyrosinase.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Azachalcones: a new class of potent polyphenol oxidase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 25, Issue:8, 2015
Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted 5-benzylidene(thio) barbiturates as novel tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Jul-01, Volume: 22, Issue:13, 2014
Chemical synthesis and tyrosinase inhibitory activity of rhododendrol glycosides.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 24, Issue:1, 2014
Effect of p-aminophenols on tyrosinase activity.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
Inhibition of tyrosinase activity by polyphenol compounds from Flemingia philippinensis roots.Bioorganic & medicinal chemistry, , Feb-01, Volume: 22, Issue:3, 2014
Microwave-assisted synthesis and tyrosinase inhibitory activity of chalcone derivatives.Chemical biology & drug design, , Volume: 82, Issue:1, 2013
Synthesis, antioxidant capacity, and structure-activity relationships of tri-O-methylnorbergenin analogues on tyrosinase inhibition.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Design and synthesis of 3,5-diaryl-4,5-dihydro-1H-pyrazoles as new tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
De novo tyrosinase inhibitor: 4-(6,7-dihydro-5H-indeno[5,6-d]thiazol-2-yl)benzene-1,3-diol (MHY1556).Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 23, Issue:14, 2013
Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Synthesis of new heterocyclic hybrids based on pyrazole and thiazolidinone scaffolds as potent inhibitors of tyrosinase.Bioorganic & medicinal chemistry, , May-15, Volume: 21, Issue:10, 2013
Design and synthesis of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as novel tyrosinase inhibitors.European journal of medicinal chemistry, , Volume: 49, 2012
Design, synthesis and molecular simulation studies of dihydrostilbene derivatives as potent tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 22, Issue:17, 2012
Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 22, Issue:12, 2012
Adamantyl N-benzylbenzamide: new series of depigmentation agents with tyrosinase inhibitory activity.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 22, Issue:5, 2012
Synthesis, biological evaluation, and molecular docking of N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl}-benzamide/amide derivatives as xanthine oxidase and tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Sep-15, Volume: 20, Issue:18, 2012
Depigmenting activity of new kojic acid derivative obtained as a side product in the synthesis of cinnamate of kojic acid.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 22, Issue:5, 2012
2-Arylbenzofuran, flavonoid, and tyrosinase inhibitory constituents of Morus yunnanensis.Journal of natural products, , Jan-27, Volume: 75, Issue:1, 2012
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.Journal of agricultural and food chemistry, , May-11, Volume: 59, Issue:9, 2011
Synthesis and biological activity of hydroxy substituted phenyl-benzo[d]thiazole analogues for antityrosinase activity in B16 cells.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 21, Issue:8, 2011
Inhibitory activity of novel kojic acid derivative containing trolox moiety on melanogenesis.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 21, Issue:24, 2011
Gusanlungionosides A-D, potential tyrosinase inhibitors from Arcangelisia gusanlung.Journal of natural products, , May-27, Volume: 74, Issue:5, 2011
Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 21, Issue:22, 2011
Prenylated flavanones with anti-tyrosinase activity from Dalea boliviana.Journal of natural products, , Feb-25, Volume: 74, Issue:2, 2011
Benzyl benzoates: New phlorizin analogs as mushroom tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Synthesis and structure-activity relationships of phenylpropanoid amides of serotonin on tyrosinase inhibition.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 21, Issue:7, 2011
Tyrosinase inhibitory activity of a 6-isoprenoid-substituted flavanone isolated from Dalea elegans.Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Refinement of arylthiosemicarbazone pharmacophore in inhibition of mushroom tyrosinase.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
Synthesis and biological activity of oxadiazole and triazolothiadiazole derivatives as tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone.European journal of medicinal chemistry, , Volume: 45, Issue:5, 2010
Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antioxidative Lamiaceae polyphenol.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 20, Issue:24, 2010
Synthesis and biological evaluation of a novel series of bis-salicylaldehydes as mushroom tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 20, Issue:20, 2010
A newly synthesized, potent tyrosinase inhibitor: 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 20, Issue:16, 2010
(-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.Bioorganic & medicinal chemistry, , Jun-01, Volume: 18, Issue:11, 2010
Tyrosinase-inhibitory constituents from the twigs of Cinnamomum cassia.Journal of natural products, , Volume: 72, Issue:6, 2009
Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Synthesis of tyrosinase inhibitory (4-oxo-4H-pyran-2-yl)acrylic acid ester derivatives.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 19, Issue:1, 2009
Kojic acid-amino acid conjugates as tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 19, Issue:19, 2009
PEG-immobilization of cardol and soluble polymer-supported synthesis of some cardol-coumarin derivatives: preliminary evaluation of their inhibitory activity on mushroom tyrosinase.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 19, Issue:1, 2009
Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz.Journal of enzyme inhibition and medicinal chemistry, , Volume: 23, Issue:6, 2008
Molecular design of potent tyrosinase inhibitors having the bibenzyl skeleton.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 18, Issue:19, 2008
1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 16, Issue:3, 2008
Antityrosinase and antioxidant effects of ent-kaurane diterpenes from leaves of Broussonetia papyrifera.Journal of natural products, , Volume: 71, Issue:11, 2008
Pyronane monoterpenoids from the fruit of Gardenia jasminoides.Journal of natural products, , Volume: 71, Issue:6, 2008
Complex sesquiterpenoids with tyrosinase inhibitory activity from the leaves of Chloranthus tianmushanensis.Journal of natural products, , Volume: 71, Issue:5, 2008
Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 15, Issue:6, 2007
Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 17, Issue:2, 2007
N-Benzylbenzamides: a new class of potent tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , May-15, Volume: 16, Issue:10, 2006
Antityrosinase principles and constituents of the petals of Crocus sativus.Journal of natural products, , Volume: 67, Issue:3, 2004
Constituents of the stigmas of Crocus sativus and their tyrosinase inhibitory activity.Journal of natural products, , Volume: 65, Issue:10, 2002
A new dimeric stilbene with tyrosinase inhibitiory activity from Artocarpus gomezianus.Journal of natural products, , Volume: 64, Issue:11, 2001
Dragon method for finding novel tyrosinase inhibitors: Biosilico identification and experimental in vitro assays.European journal of medicinal chemistry, , Volume: 42, Issue:11-12
Characterization of the action of tyrosinase on resorcinols.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
PEG-immobilization of cardol and soluble polymer-supported synthesis of some cardol-coumarin derivatives: preliminary evaluation of their inhibitory activity on mushroom tyrosinase.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 19, Issue:1, 2009
Tyrosinase inhibitors from Anacardium occidentale fruits.Journal of natural products, , Volume: 57, Issue:4, 1994
Synthesis and tyrosinase inhibitory activities of 4-oxobutanoate derivatives of carvacrol and thymol.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 29, Issue:1, 2019
Design, synthesis and evaluation of cinnamic acid ester derivatives as mushroom tyrosinase inhibitors.MedChemComm, , May-01, Volume: 9, Issue:5, 2018
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.Journal of agricultural and food chemistry, , May-11, Volume: 59, Issue:9, 2011
Synthesis and biological evaluation of a novel series of bis-salicylaldehydes as mushroom tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 20, Issue:20, 2010
Discovery of a new type of scaffold for the creation of novel tyrosinase inhibitors.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Synthesis, antioxidant capacity, and structure-activity relationships of tri-O-methylnorbergenin analogues on tyrosinase inhibition.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Characterization of the action of tyrosinase on resorcinols.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Synthesis and preliminary in vitro biological evaluation of 4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-mercaptophenol derivative designed as a novel bifunctional antimelanoma agent.Journal of medicinal chemistry, , Aug-13, Volume: 52, Issue:15, 2009
Investigating the selectivity of metalloenzyme inhibitors.Journal of medicinal chemistry, , Oct-24, Volume: 56, Issue:20, 2013
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.Journal of medicinal chemistry, , Jan-27, Volume: 54, Issue:2, 2011
Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 19, Issue:21, 2009
A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds.European journal of medicinal chemistry, , Volume: 44, Issue:4, 2009
1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 16, Issue:3, 2008
Inhibitors of Melanogenesis: An Updated Review.Journal of medicinal chemistry, , 09-13, Volume: 61, Issue:17, 2018
Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
Inhibitors of Melanogenesis: An Updated Review.Journal of medicinal chemistry, , 09-13, Volume: 61, Issue:17, 2018
Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle).Bioorganic & medicinal chemistry, , 06-15, Volume: 27, Issue:12, 2019
Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
TOMOCOMD-CARDD descriptors-based virtual screening of tyrosinase inhibitors: evaluation of different classification model combinations using bond-based linear indices.Bioorganic & medicinal chemistry, , Feb-01, Volume: 15, Issue:3, 2007
Dragon method for finding novel tyrosinase inhibitors: Biosilico identification and experimental in vitro assays.European journal of medicinal chemistry, , Volume: 42, Issue:11-12
From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical.European journal of medicinal chemistry, , Dec-15, Volume: 184, 2019
De Novo Molecular Design of a Novel Octapeptide That Inhibits In Vivo Melanogenesis and Has Great Transdermal Ability.Journal of medicinal chemistry, , Aug-09, Volume: 61, Issue:15, 2018
Dimeric cinnamoylamide analogues for regulation of tyrosinase activity in melanoma cells: A role of diamide-link chain length.Bioorganic & medicinal chemistry, , 12-15, Volume: 26, Issue:23-24, 2018
N-Acyl Dehydrotyrosines, Tyrosinase Inhibitors from the Marine Bacterium Thalassotalea sp. PP2-459.Journal of natural products, , Feb-26, Volume: 79, Issue:2, 2016
Synthesis, antioxidant capacity, and structure-activity relationships of tri-O-methylnorbergenin analogues on tyrosinase inhibition.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Tyrosinase inhibitory activity of a 6-isoprenoid-substituted flavanone isolated from Dalea elegans.Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Synthesis and structure-activity relationships of phenylpropanoid amides of serotonin on tyrosinase inhibition.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 21, Issue:7, 2011
Evaluation of dihydropyrimidin-(2H)-one analogues and rhodanine derivatives as tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 21, Issue:8, 2011
Design and synthesis of biphenyl derivatives as mushroom tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Sep-15, Volume: 18, Issue:18, 2010
Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 19, Issue:21, 2009
A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds.European journal of medicinal chemistry, , Volume: 44, Issue:4, 2009
1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 16, Issue:3, 2008
Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Antityrosinase principles and constituents of the petals of Crocus sativus.Journal of natural products, , Volume: 67, Issue:3, 2004
Constituents of the stigmas of Crocus sativus and their tyrosinase inhibitory activity.Journal of natural products, , Volume: 65, Issue:10, 2002
Tyrosinase inhibitors from Anacardium occidentale fruits.Journal of natural products, , Volume: 57, Issue:4, 1994
Design, synthesis and evaluation of cinnamic acid ester derivatives as mushroom tyrosinase inhibitors.MedChemComm, , May-01, Volume: 9, Issue:5, 2018
Synthesis and structure-activity relationships of phenylpropanoid amides of serotonin on tyrosinase inhibition.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 21, Issue:7, 2011
Tyrosinase-inhibitory constituents from the twigs of Cinnamomum cassia.Journal of natural products, , Volume: 72, Issue:6, 2009
Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 22, Issue:24, 2012
A newly synthesized, potent tyrosinase inhibitor: 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 20, Issue:16, 2010
Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 17, Issue:2, 2007
Design, synthesis and evaluation of cinnamic acid ester derivatives as mushroom tyrosinase inhibitors.MedChemComm, , May-01, Volume: 9, Issue:5, 2018
Synthesis and structure-activity relationships of phenylpropanoid amides of serotonin on tyrosinase inhibition.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 21, Issue:7, 2011
Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase.European journal of medicinal chemistry, , Dec-01, Volume: 106, 2015
Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 21, Issue:22, 2011
Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Synthesis and structure-activity relationships of phenylpropanoid amides of serotonin on tyrosinase inhibition.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 21, Issue:7, 2011
Evaluation of dihydropyrimidin-(2H)-one analogues and rhodanine derivatives as tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 21, Issue:8, 2011
Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors.European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010
Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities.European journal of medicinal chemistry, , Volume: 44, Issue:10, 2009
A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds.European journal of medicinal chemistry, , Volume: 44, Issue:4, 2009
1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 16, Issue:3, 2008
Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.Bioorganic & medicinal chemistry, , Jun-01, Volume: 18, Issue:11, 2010
New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.Bioorganic & medicinal chemistry, , Jun-01, Volume: 18, Issue:11, 2010
Isolation of Flavonoids and Flavonoid Glycosides from Myrsine africana and Their Inhibitory Activities against Mushroom Tyrosinase.Journal of natural products, , 01-26, Volume: 81, Issue:1, 2018
Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Tyrosinase inhibitors from Bolivian medicinal plants.Journal of natural products, , Volume: 58, Issue:5, 1995
Changes in flavonoid content and tyrosinase inhibitory activity in kenaf leaf extract after far-infrared treatment.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 20, Issue:24, 2010
Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Design and synthesis of 3,5-diaryl-4,5-dihydro-1H-pyrazoles as new tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz.Journal of enzyme inhibition and medicinal chemistry, , Volume: 23, Issue:6, 2008
Synthesis and evaluation of 5-benzylidene(thio)barbiturate-beta-D-glycosides as mushroom tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Design and synthesis of 3,5-diaryl-4,5-dihydro-1H-pyrazoles as new tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 15, Issue:6, 2007
Design and synthesis of 3,5-diaryl-4,5-dihydro-1H-pyrazoles as new tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Tyrosinase inhibitory activity of a 6-isoprenoid-substituted flavanone isolated from Dalea elegans.Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
[no title available]European journal of medicinal chemistry, , Aug-01, Volume: 175, 2019
Benzo[b]thiophene-thiazoles as potent anti-Toxoplasma gondii agents: Design, synthesis, tyrosinase/tyrosine hydroxylase inhibitors, molecular docking study, and antioxidant activity.European journal of medicinal chemistry, , Dec-15, Volume: 184, 2019
Isolation of Flavonoids and Flavonoid Glycosides from Myrsine africana and Their Inhibitory Activities against Mushroom Tyrosinase.Journal of natural products, , 01-26, Volume: 81, Issue:1, 2018
Tyrosinase inhibitory activity of a 6-isoprenoid-substituted flavanone isolated from Dalea elegans.Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011