Hypoxia-inducible factor 1-alpha inhibitor

A hypoxia-inducible factor 1-alpha inhibitor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NWT6]

Synonyms

EC 1.14.11.30;
EC 1.14.11.n4;
Factor inhibiting HIF-1;
FIH-1;
Hypoxia-inducible factor asparagine hydroxylase

Research

Bioassay Publications (8)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (37.50)	29.6817
2010's	4 (50.00)	24.3611
2020's	1 (12.50)	2.80

Compounds (12)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
succinylacetone	Homo sapiens (human)	IC50	100.0000	1	1
2,4-pyridinedicarboxylic acid	Homo sapiens (human)	IC50	8.6000	1	1
daminozide	Homo sapiens (human)	IC50	100.0000	1	1
d-2-hydroxyglutarate	Homo sapiens (human)	IC50	189.0000	1	1
alpha-hydroxyglutarate, (l)-isomer	Homo sapiens (human)	IC50	1,500.0000	1	1
oxalylglycine	Homo sapiens (human)	IC50	46.0000	1	1
oxalylglycine	Homo sapiens (human)	Ki	1,200.0000	2	2
quercetin	Homo sapiens (human)	IC50	10.2000	1	1
fg-4592	Homo sapiens (human)	IC50	100.0000	1	1
bay 85-3934	Homo sapiens (human)	IC50	48.5000	2	2
gsk1278863	Homo sapiens (human)	IC50	21.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
alpha-ketoglutaric acid	Homo sapiens (human)	Km	25.0000	1	1
ascorbic acid	Homo sapiens (human)	Km	260.0000	1	1

Enables

This protein enables 13 target(s):

Target	Category	Definition
transcription corepressor activity	molecular function	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
Notch binding	molecular function	Binding to a Notch (N) protein, a surface receptor. [GOC:ceb]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ferrous iron binding	molecular function	Binding to a ferrous iron ion, Fe(II). [GOC:ai]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
oxygen sensor activity	molecular function	Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2). [GOC:mah]
carboxylic acid binding	molecular function	Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-). [GOC:mah, ISBN:0198506732]
peptidyl-histidine dioxygenase activity	molecular function	Catalysis of the reaction: L-histidyl-[protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + succinate + CO2. [PMID:21251231, RHEA:54256]
[protein]-asparagine 3-dioxygenase activity	molecular function	Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2. [GOC:reh, PMID:12215170, RHEA:54260]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
NF-kappaB binding	molecular function	Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. [GOC:ai]
peptidyl-aspartic acid 3-dioxygenase activity	molecular function	Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2. [PMID:1378441, PMID:1856229, RHEA:11508]
ankyrin repeat binding	molecular function	Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure. [GOC:mah, InterPro:IPR002110]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 4 target(s):

Target	Category	Definition
positive regulation of myoblast differentiation	biological process	Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
negative regulation of Notch signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway. [GOC:go_curators]
negative regulation of DNA-templated transcription	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of vasculogenesis	biological process	Any process that activates or increases the frequency, rate or extent of vasculogenesis. [GOC:obol]