Dehydroabietic acid is a naturally occurring diterpenoid resin acid found in various coniferous trees, particularly in the resin of pines. It is a white, crystalline solid with a molecular formula of C20H28O2. Dehydroabietic acid has garnered significant interest in research due to its diverse biological activities and potential applications in various fields.
**Synthesis:**
* Dehydroabietic acid can be synthesized through various chemical processes, including:
* Extraction from natural sources like pine resin.
* Chemical modification of other resin acids, such as abietic acid.
* Biocatalytic methods using microbial enzymes.
**Biological Effects:**
* **Antioxidant Activity:** Dehydroabietic acid exhibits potent antioxidant properties, scavenging free radicals and protecting cells from oxidative damage.
* **Anti-inflammatory Activity:** It has demonstrated anti-inflammatory effects, inhibiting the production of inflammatory mediators.
* **Antimicrobial Activity:** Dehydroabietic acid shows promising antimicrobial activity against a range of bacteria and fungi.
* **Anti-cancer Activity:** Studies have indicated potential anticancer properties, inhibiting the growth and proliferation of certain cancer cell lines.
**Importance and Research Focus:**
* **Biofuel Production:** Dehydroabietic acid and other resin acids hold promise as potential renewable feedstocks for biofuel production.
* **Pharmaceutical Applications:** Its diverse biological activities make it a potential candidate for developing new pharmaceuticals, particularly in the fields of anti-inflammatories, antimicrobials, and anticancer agents.
* **Industrial Applications:** Dehydroabietic acid finds applications in various industrial settings, including:
* Additives for resins and polymers.
* Surfactants and emulsifiers.
* Synthesis of other valuable chemicals.
Dehydroabietic acid continues to be a subject of ongoing research, focusing on understanding its mechanisms of action, optimizing its synthesis, and exploring its potential applications in various fields.'
dehydroabietic acid: major aquatic toxicant in effluent of pulp and paper mills [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
dehydroabietic acid : An abietane diterpenoid that is abieta-8,11,13-triene substituted at position 18 by a carboxy group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
dehydroabietate : A monocarboxylic acid anion that is the conjugate base of dehydroabietic acid, obtained by deprotonation of the carboxy group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 94391 |
| CHEMBL ID | 12850 |
| CHEBI ID | 29571 |
| SCHEMBL ID | 222078 |
| MeSH ID | M0062050 |
| Synonym |
|---|
| 4-09-00-02389 (beilstein handbook reference) |
| unii-0s5xp6s3au |
| 0s5xp6s3au , |
| abieta-8,13-trien-18-oic acid |
| nsc-2952 |
| abietic acid, dehydro- |
| 1,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenecarboxylic acid |
| podocarpa-8,13-trien-15-oic acid, 13-isopropyl- |
| 13-isopropylpodocarpa-8,13-trien-15-oic acid |
| 1-phenanthrenecarboxylic acid,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, [1r-(1.alpha.,4a.beta.,10a.alpha.)]- |
| nsc2952 , |
| abieta-8(14),9(11),12-trien-18-oic acid |
| S3226 , |
| einecs 217-102-8 |
| isopropyl podocarpa-8,11,13-trien-15-oic acid |
| (1r-(1alpha,4abeta,10aalpha))-1,2,3,4,4a,9,10,10a-octahydro-7-isopropyl-1,4a-dimethylphenanthren-1-carboxylic acid |
| brn 2059290 |
| nsc 2952 |
| 1-phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, (1r-(1alpha,4abeta,10aalpha))- |
| podocarpa-8,11,13-trien-15-oic acid, 13-isopropyl- |
| 1-phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, (1r,4as,10ar)- |
| inchi=1/c20h28o2/c1-13(2)14-6-8-16-15(12-14)7-9-17-19(16,3)10-5-11-20(17,4)18(21)22/h6,8,12-13,17h,5,7,9-11h2,1-4h3,(h,21,22)/t17-,19-,20-/m1/s |
| abieta-8,11,13-trien-18-oic acid |
| 1740-19-8 |
| 13-isopropylpodocarpa-8,11,13-trien-15-oic acid |
| dehydroabietate |
| dehydroabietic acid |
| (-)-dehydroabietic acid |
| LMPR0104050005 |
| bdbm50143600 |
| 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenecarboxylic acid |
| CHEBI:29571 , |
| CHEMBL12850 |
| AKOS015917291 |
| FT-0633812 |
| SCHEMBL222078 |
| (1r-(1alpha,4abeta,10aalpha))-1,2,3,4,4a,9,10,10a-octahydro- 7-isopropyl-1,4a-dimethylphenanthren-1-carboxylic acid |
| 1-phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a- octahydro-1,4a-dimethyl-7-(1-methylethyl)-, (1r,4as,10ar)- |
| NFWKVWVWBFBAOV-MISYRCLQSA-N |
| W-107855 |
| mfcd09839012 |
| DTXSID8022163 |
| dehydroabietic acid, >=95% (lc/ms-elsd) |
| HY-N6869 |
| Q27110153 |
| 6980-63-8 |
| rel-(1r,4as,10ar)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid |
| AMY22483 |
| CS-W012130 |
| A881721 |
| 5-podocarpa-8,11,13-trien-15-oic acid, 13-isopropyl- |
| 1-phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, [1r-(1,4a,10a)]- |
| AC-34629 |
| (1r,4as,10ar)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid |
| EN300-6730478 |
| (+)-dehydroabietic acid, tech grade |
| rel-(1r,4as,10ar)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylicacid |
Dehydroabietic acid (DAA) is a naturally occurring diterpene resin acid derived from coniferous plants such as pinus species. It is a food-derived terpenoid with various bioactivities. It's a major component of rosin.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Dehydroabietic acid derivatives have been reported to display antisecretory and antipepsin effect in animal models. " | ( Gastroprotective and cytotoxic effect of dehydroabietic acid derivatives. Astudillo, L; Rodríguez, JA; Schmeda-Hirschmann, G; Sepúlveda, B; Theoduloz, C; Yáñez, T, 2005) | 2.04 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Dehydroabietic acid (DHAA) plays an important role in drug discovery. " | ( Synthesis and antimicrobial evaluation of novel analogues of dehydroabietic acid prepared by CH-Activation. Berger, M; Maulide, N; Roller, A, 2017) | 2.14 |
Dehydroabietic acid and the oleoresin were the most toxic compounds followed by O-methylpodocarpic acid, whereas podocarpIC acid and tea tree oil showed a lower level of toxicity.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Dose-response studies indicated that unbleached effluents contained more potent toxic substances than bleached effluents." | ( Toxic effects of bleached and unbleached paper mill effluents in primary cultures of rainbow trout hepatocytes. Andersson, T; Pesonen, M, 1992) | 0.28 |
| " Albumin slightly reduced the toxic effects, whereas the addition of zinc in various forms strongly inhibited these toxic effects of DHAA in the concentration range of 10-500 micrograms/mL." | ( Neutralizing effect of zinc oxide on dehydroabietic acid-induced toxicity on human polymorphonuclear leukocytes. Hallmans, G; Hänström, L; Holm, SE; Reuterving, CO; Söderberg, TA; Sunzel, B, 1991) | 0.55 |
| " Albumin slightly reduced the toxic effects, whereas the addition of zinc in various forms strongly inhibited these toxic effects of DHAA in the concentration range 10-500 micrograms/mL." | ( Neutralizing effect of zinc oxide on dehydroabietic acid-induced toxicity on human polymorphonuclear leukocytes. Hallmans, G; Hänström, L; Holm, SE; Reuterving, CO; Söderberg, TA; Sunzel, B, 1991) | 0.55 |
| " The fish kill was associated to the outbreak of infectious diseases, spring viremia of carp and saprolegniosis, related to an increase in the fish's susceptibility due to the presence of a toxic chemical." | ( Toxicity identification evaluations for the investigation of fish kills: a case study. Blazquez, T; Carballo, M; Carbonell, G; Castaño, A; Muñoz, MJ; Ortiz, JA; Tarazona, JV; Vega, M, 1994) | 0.29 |
| " Dehydroabietic acid and the oleoresin were the most toxic compounds followed by O-methylpodocarpic acid, whereas podocarpic acid and tea tree oil showed a lower level of toxicity." | ( Toxic effects of some conifer resin acids and tea tree oil on human epithelial and fibroblast cells. Gref, R; Johansson, A; Söderberg, TA, 1996) | 1.2 |
| " Retene (10-320 microg l(-1)) was not acutely toxic in the dark." | ( Photoinduced toxicity of retene to Daphnia magna under enhanced UV-B radiation. Huovinen, PS; Oikari, AO; Soimasuo, MR, 2001) | 0.31 |
| " Herein, we discovered and developed four new self-assembled tricyclic diterpene acids NSMP with favorable anticancer activity for synergistic and safe antitumor chemotherapy, including dehydroabietic acid, 15-hydroxy-dehydroabietic acid, abietic acid, and 12-hydroxyabietic acid." | ( Self-assembled natural small molecule diterpene acids with favorable anticancer activity and biosafety for synergistically enhanced antitumor chemotherapy. Cheng, J; Fu, S; Han, Y; Qin, Z; Yang, X, 2021) | 0.81 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Triptolide is a valuable multipotent antitumor diterpenoid in Tripterygium wilfordii, and its C-14 hydroxyl group is often selected for modification to enhance both the bioavailability and antitumor efficacy." | ( Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae. Gao, J; Gao, W; Hu, T; Huang, L; Li, D; Liu, Y; Lu, Y; Ma, L; Su, P; Tong, Y; Tu, L; Wang, J; Wu, X; Yin, Y; Zhang, Y; Zhao, H; Zhao, Y; Zhou, J, 2023) | 0.91 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response studies indicated that unbleached effluents contained more potent toxic substances than bleached effluents." | ( Toxic effects of bleached and unbleached paper mill effluents in primary cultures of rainbow trout hepatocytes. Andersson, T; Pesonen, M, 1992) | 0.28 |
| " Endpoints of those dose-response studies included critical swimming speed, oxygen consumption, and hematology." | ( Combined effects of pulp and paper effluent, dehydroabietic acid, and hypoxia on swimming performance, metabolism, and hematology of rainbow trout. Bannon, HJ; Finley, M; Landman, MJ; Ling, N; van den Heuvel, MR, 2006) | 0.59 |
| Role | Description |
|---|---|
| metabolite | Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. |
| allergen | A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| abietane diterpenoid | A diterpenoid based on an abietane skeleton. |
| monocarboxylic acid | An oxoacid containing a single carboxy group. |
| carbotricyclic compound | A carbopolyclic compound comprising of three carbocyclic rings. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Pathway | Proteins | Compounds |
|---|---|---|
| dehydroabietic acid biosynthesis | 5 | 12 |
| superpathway of diterpene resin acids biosynthesis | 5 | 23 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| G1/S-specific cyclin-E1 | Homo sapiens (human) | IC50 (µMol) | 36.2900 | 0.0010 | 1.0404 | 10.0000 | AID1275126 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 (µMol) | 36.2900 | 0.0004 | 1.0444 | 10.0000 | AID1275126 |
| Tyrosine-protein kinase JAK3 | Homo sapiens (human) | IC50 (µMol) | 0.1000 | 0.0001 | 0.4193 | 7.9200 | AID1410147 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 36.2900 | 0.0030 | 1.6943 | 7.0795 | AID1275126 |
| Lysine--tRNA ligase | Homo sapiens (human) | IC50 (µMol) | 0.0277 | 0.0009 | 0.3073 | 1.4740 | AID1410144 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | EC50 (µMol) | 42.0000 | 0.0001 | 0.3427 | 9.1000 | AID1355434 |
| Retinoic acid receptor RXR-beta | Homo sapiens (human) | EC50 (µMol) | 42.0000 | 0.0008 | 0.5254 | 5.2000 | AID1355437 |
| Retinoic acid receptor RXR-gamma | Homo sapiens (human) | EC50 (µMol) | 42.0000 | 0.0001 | 0.2380 | 1.2250 | AID1355440 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1295874 | Cytotoxicity in human A549 cells by SRB assay | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Diterpenes from the Trunk of Abies holophylla and Their Potential Neuroprotective and Anti-inflammatory Activities. |
| AID1175297 | Antifungal activity against Trametes versicolor after 3 to 5 days by paper disc method relative to 1227 | 2015 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 25, Issue:2 | Quantitative structure-activity relationship of antifungal activity of rosin derivatives. |
| AID471490 | Cytotoxicity against african green monkey Vero cells assessed as minimal toxic dosed detached 100% of the cell monolayer | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis and biological evaluation of dehydroabietic acid derivatives. |
| AID1076718 | Cytotoxicity against human Bel7404 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Synthesis and antitumor activities of novel dipeptide derivatives derived from dehydroabietic acid. |
| AID332338 | Antimicrobial activity against Bacillus subtilis 327 after 18 hrs by microbroth dilution method | 2003 | Journal of natural products, Feb, Volume: 66, Issue:2 | Antibacterial diterpenes from Calceolaria pinifolia. |
| AID1174411 | Cytotoxicity against human HL7702 cells after 48 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Jan-07, Volume: 89 | Design, synthesis and in vitro evaluation of novel dehydroabietic acid derivatives containing a dipeptide moiety as potential anticancer agents. |
| AID1410134 | Inhibition of JAK3 (unknown origin) at 50 ug/ml by mobility shift assay relative to control | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
| AID1491120 | Anticonvulsant activity in 7-days post fertilized zebra fish larvae assessed as reduction in pentylenetetrazol-induced locomotor activity by measuring total distance traveled by larvae at 1.5 to 6 uM pretreated for 3 hrs followed by pentylenetetrazol addi | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5 | HPLC-Based Activity Profiling for GABA |
| AID1275098 | Cytotoxic activity against human HCT116 cells assessed as inhibition of cell growth after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Jan-27, Volume: 108 | Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis. |
| AID332341 | Antimicrobial activity against Escherichia coli imp 389 after 18 hrs by microbroth dilution method | 2003 | Journal of natural products, Feb, Volume: 66, Issue:2 | Antibacterial diterpenes from Calceolaria pinifolia. |
| AID1410135 | Inhibition of ZAP70 (unknown origin) at 50 ug/ml by mobility shift assay relative to control | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
| AID471481 | Antifungal activity against Aspergillus terreus after 24 hrs by AFST-EUCAST method | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis and biological evaluation of dehydroabietic acid derivatives. |
| AID1355441 | Transactivation of human Gal4-fused RXRgamma LBD expressed in HEK293T cells after 12 to 14 hrs by dual-glo luciferase assay relative to bexarotene | 2018 | Journal of medicinal chemistry, 06-28, Volume: 61, Issue:12 | Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics. |
| AID1378663 | Inhibition of recombinant human MMP3 (Tyr18 to Cys477 residues) expressed in mouse myeloma cells using Mca-Pro-LeuGly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation. |
| AID398026 | Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 100 mol ratio relative to TPA | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis. |
| AID457057 | Inhibition of TNF-alpha-induced NF-kappaB activity in human pNF-kappaB-luc-293 cells | 2010 | Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2 | Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr. |
| AID1076720 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Synthesis and antitumor activities of novel dipeptide derivatives derived from dehydroabietic acid. |
| AID755551 | Cytotoxicity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13 | Anticancer effects of a novel class rosin-derivatives with different mechanisms. |
| AID1392011 | Antistaphylococcal activity against erythromycin-resistant Staphylococcus aureus NRS-70 after 18 hrs by two-fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid. |
| AID1431162 | Antibacterial activity against Staphylococcus aureus Newman after 18 hrs by two fold serial dilution method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: modifications at C12 and C7. |
| AID1374759 | Cytotoxicity against HUVEC assessed as reduction in cell viability up to 100 uM after 24 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 28, Issue:6 | 7α,15-Dihydroxydehydroabietic acid from Pinus koraiensis inhibits the promotion of angiogenesis through downregulation of VEGF, p-Akt and p-ERK in HUVECs. |
| AID1410147 | Inhibition of JAK3 (unknown origin) by mobility shift assay | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
| AID1378665 | Inhibition of recombinant human MMP9 (Ala20 to Asp707 residues) expressed in CHO cells using Mca-Pro-LeuGly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation. |
| AID1378664 | Inhibition of recombinant human MMP8 (Phe21 to Gly467 residues) expressed in mouse myeloma cells using Mca-Pro-LeuGly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation. |
| AID1355457 | Transactivation of RXR in human HepG2 cells assessed as induction of ABCA1 mRNA expression at 30 uM after 8 hrs by qRT-PCR analysis | 2018 | Journal of medicinal chemistry, 06-28, Volume: 61, Issue:12 | Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics. |
| AID1295870 | Neuroprotective activity in rat C6 cells assessed as induction of NGF release at 20 uM after 24 hrs by ELISA | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Diterpenes from the Trunk of Abies holophylla and Their Potential Neuroprotective and Anti-inflammatory Activities. |
| AID471488 | Selectivity index, ratio of IC50 for african green monkey Vero cells to IC50 for human Jurkat cells | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis and biological evaluation of dehydroabietic acid derivatives. |
| AID471484 | Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis and biological evaluation of dehydroabietic acid derivatives. |
| AID1355434 | Transactivation of human Gal4-fused RXRalpha LBD expressed in HEK293T cells after 12 to 14 hrs by dual-glo luciferase assay | 2018 | Journal of medicinal chemistry, 06-28, Volume: 61, Issue:12 | Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics. |
| AID1355435 | Transactivation of human Gal4-fused RXRalpha LBD expressed in HEK293T cells after 12 to 14 hrs by dual-glo luciferase assay relative to bexarotene | 2018 | Journal of medicinal chemistry, 06-28, Volume: 61, Issue:12 | Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics. |
| AID1172521 | Antiulcer activity in rat assessed as inhibition of secretion at 30 mg/kg, ip | 2014 | European journal of medicinal chemistry, Nov-24, Volume: 87 | Synthetic derivatives of aromatic abietane diterpenoids and their biological activities. |
| AID381370 | Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 10 mol ratio relative to TPA | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6 | Potential antitumor-promoting diterpenoids from the stem bark of Picea glehni. |
| AID1378670 | Cytotoxicity against human HL-7702 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation. |
| AID774810 | Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 23, Issue:19 | Synthesis and antitumor activities of novel α-aminophosphonates dehydroabietic acid derivatives. |
| AID1392014 | Antistaphylococcal activity against linezolid-resistant Staphylococcus aureus NRS-271 containing phage type E-MRSA 15 after 18 hrs by two-fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid. |
| AID755528 | Cytotoxicity against human 5637 cells assessed as growth inhibition after 72 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13 | Anticancer effects of a novel class rosin-derivatives with different mechanisms. |
| AID1378667 | Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation. |
| AID1410132 | Inhibition of PKA (unknown origin) at 50 ug/ml by mobility shift assay relative to control | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
| AID1431168 | Antibacterial activity against Escherichia coli AB1157 at 50 ug/ml after 18 hrs by two fold serial dilution method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: modifications at C12 and C7. |
| AID1275126 | Inhibition of human recombinant C-terminal His6-tagged full length human Cdk2/human recombinant N-terminal GST-tagged full-length Cyclin E using histone H1 substrate after 40 mins by radiometric filter binding assay | 2016 | European journal of medicinal chemistry, Jan-27, Volume: 108 | Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis. |
| AID1867227 | Toxicity against human MIA PaCa-2 cells in nutrient-rich medium (DMEM) | 2022 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 66 | Abietane diterpenes from Abies spectabilis and their anti-pancreatic cancer activity against the MIA PaCa-2 cell line. |
| AID755529 | Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13 | Anticancer effects of a novel class rosin-derivatives with different mechanisms. |
| AID1355440 | Transactivation of human Gal4-fused RXRgamma LBD expressed in HEK293T cells after 12 to 14 hrs by dual-glo luciferase assay | 2018 | Journal of medicinal chemistry, 06-28, Volume: 61, Issue:12 | Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics. |
| AID1174408 | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Jan-07, Volume: 89 | Design, synthesis and in vitro evaluation of novel dehydroabietic acid derivatives containing a dipeptide moiety as potential anticancer agents. |
| AID1295871 | Cytotoxicity in rat C6 cells assessed as cell viability at 20 uM after 24 hrs by MTT assay | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Diterpenes from the Trunk of Abies holophylla and Their Potential Neuroprotective and Anti-inflammatory Activities. |
| AID1355447 | Transactivation of human Gal4-fused PPARgamma LBD expressed in HEK293T cells at 30 uM after 12 to 14 hrs by dual-glo luciferase assay | 2018 | Journal of medicinal chemistry, 06-28, Volume: 61, Issue:12 | Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics. |
| AID1378668 | Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation. |
| AID1410130 | Inhibition of PKCdelta (unknown origin) at 50 ug/ml by mobility shift assay relative to control | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
| AID1275097 | Cytotoxic activity against human A549 cells assessed as inhibition of cell growth after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Jan-27, Volume: 108 | Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis. |
| AID1355433 | Transactivation of human Gal4-fused RXRalpha LBD expressed in HEK293T cells at 30 uM after 12 to 14 hrs by dual-glo luciferase assay | 2018 | Journal of medicinal chemistry, 06-28, Volume: 61, Issue:12 | Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics. |
| AID471493 | Antiviral activity against Human herpesvirus 1 infected in human HeLa cells assessed as ratio of viral titer in absence of drug over viral titer in presence of drug after 36 hrs by end point titration method | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis and biological evaluation of dehydroabietic acid derivatives. |
| AID1410139 | Inhibition of PIM1 (unknown origin) at 50 ug/ml by mobility shift assay relative to control | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
| AID398024 | Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 1000 mol ratio relative to TPA | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis. |
| AID1392012 | Antistaphylococcal activity against oxacillin/tetracycline-resistant Staphylococcus aureus NRS-100 after 18 hrs by two-fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid. |
| AID1410128 | Inhibition of FAK (unknown origin) at 50 ug/ml by Lanthascreen assay relative to control | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
| AID1368175 | Antibacterial activity against Bacillus subtilis measured after 24 hrs | 2017 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 27, Issue:24 | Identification of a diverse synthetic abietane diterpenoid library and insight into the structure-activity relationships for antibacterial activity. |
| AID1325496 | Antibacterial activity against erythromycin-resistant Staphylococcus aureus NRS-70 | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22 | The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: Modifications at C-12. |
| AID1076719 | Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Synthesis and antitumor activities of novel dipeptide derivatives derived from dehydroabietic acid. |
| AID1378666 | Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation. |
| AID471486 | Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis and biological evaluation of dehydroabietic acid derivatives. |
| AID1410131 | Inhibition of SYK (unknown origin) at 50 ug/ml by mobility shift assay relative to control | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
| AID1374760 | Antiangiogenic activity against HUVEC assessed as reduction in tube formation at 12.5 uM after 24 hrs by matrigel-based light microscopic analysis relative to control | 2018 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 28, Issue:6 | 7α,15-Dihydroxydehydroabietic acid from Pinus koraiensis inhibits the promotion of angiogenesis through downregulation of VEGF, p-Akt and p-ERK in HUVECs. |
| AID1325497 | Antibacterial activity against oxacillin/tetracycline-resistant Staphylococcus aureus NRS-100 | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22 | The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: Modifications at C-12. |
| AID1175298 | Antifungal activity against Gloeophyllum trabeum after 3 to 5 days by paper disc method relative to 1227 | 2015 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 25, Issue:2 | Quantitative structure-activity relationship of antifungal activity of rosin derivatives. |
| AID1246300 | Cytotoxicity against human HepG2 cells at <= 50 uM after 72 hrs by CellTiter-Glo assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | (+)-Dehydroabietylamine derivatives target triple-negative breast cancer. |
| AID1275095 | Cytotoxic activity against human SKOV3 cells assessed as inhibition of cell growth after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Jan-27, Volume: 108 | Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis. |
| AID1295875 | Cytotoxicity in human SKOV3 cells by SRB assay | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Diterpenes from the Trunk of Abies holophylla and Their Potential Neuroprotective and Anti-inflammatory Activities. |
| AID1172523 | Gastroprotective activity in mouse assessed as reduction in HCl/EtOH-induced gastric lesions at 100 mg/kg | 2014 | European journal of medicinal chemistry, Nov-24, Volume: 87 | Synthetic derivatives of aromatic abietane diterpenoids and their biological activities. |
| AID774807 | Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 23, Issue:19 | Synthesis and antitumor activities of novel α-aminophosphonates dehydroabietic acid derivatives. |
| AID1355458 | Transactivation of RXR in human HepG2 cells assessed as induction of apoE mRNA expression at 30 uM after 8 hrs by qRT-PCR analysis | 2018 | Journal of medicinal chemistry, 06-28, Volume: 61, Issue:12 | Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics. |
| AID776386 | Cytotoxicity against human NCI-H460 cells after 3 days by MTT assay | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and antitumor activities of novel thiourea α-aminophosphonates from dehydroabietic acid. |
| AID1295876 | Cytotoxicity in human SK-MEL-2 cells by SRB assay | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Diterpenes from the Trunk of Abies holophylla and Their Potential Neuroprotective and Anti-inflammatory Activities. |
| AID471494 | Antiviral activity against Human herpesvirus 1 infected in human HeLa cells assessed as maximal nontoxic dose caused highest viral reduction factor after 36 hrs by end point titration method | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis and biological evaluation of dehydroabietic acid derivatives. |
| AID1410138 | Inhibition of GSK3b (unknown origin) at 50 ug/ml by mobility shift assay relative to control | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
| AID1867226 | Preferential cytotoxicity against human MIA PaCa-2 cells in nutrient-deprived medium | 2022 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 66 | Abietane diterpenes from Abies spectabilis and their anti-pancreatic cancer activity against the MIA PaCa-2 cell line. |
| AID1368176 | Antibacterial activity against Escherichia coli measured after 24 hrs | 2017 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 27, Issue:24 | Identification of a diverse synthetic abietane diterpenoid library and insight into the structure-activity relationships for antibacterial activity. |
| AID1325495 | Antibacterial activity against aminoglycosides/tetracycline-resistant Staphylococcus aureus NRS-1 | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22 | The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: Modifications at C-12. |
| AID1434299 | Cytotoxic activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by SRB assay | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Identification of a diverse synthetic abietane diterpenoid library for anticancer activity. |
| AID1246298 | Antiproliferative activity against human triple-negative MDA-MB-231 cells at <= 50 uM after 72 hrs by CellTiter-Glo assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | (+)-Dehydroabietylamine derivatives target triple-negative breast cancer. |
| AID1410133 | Inhibition of ALK (unknown origin) at 50 ug/ml by mobility shift assay relative to control | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
| AID1368177 | Antibacterial activity against Pseudomonas fluorescens measured after 24 hrs | 2017 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 27, Issue:24 | Identification of a diverse synthetic abietane diterpenoid library and insight into the structure-activity relationships for antibacterial activity. |
| AID1325494 | Antibacterial activity against Staphylococcus aureus Newman | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22 | The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: Modifications at C-12. |
| AID381371 | Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio/TPA | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6 | Potential antitumor-promoting diterpenoids from the stem bark of Picea glehni. |
| AID1378669 | Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation. |
| AID332340 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 310 after 18 hrs by microbroth dilution method | 2003 | Journal of natural products, Feb, Volume: 66, Issue:2 | Antibacterial diterpenes from Calceolaria pinifolia. |
| AID1392013 | Antistaphylococcal activity against gentamicin-resistant Staphylococcus aureus NRS-108 after 18 hrs by two-fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid. |
| AID1295877 | Cytotoxicity in human HCT116 cells by SRB assay | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Diterpenes from the Trunk of Abies holophylla and Their Potential Neuroprotective and Anti-inflammatory Activities. |
| AID1410140 | Inhibition of PDK1 (unknown origin) at 50 ug/ml by mobility shift assay relative to control | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
| AID1410136 | Inhibition of SRC (unknown origin) at 50 ug/ml by mobility shift assay relative to control | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
| AID1392010 | Antistaphylococcal activity against aminoglycosides/tetracycline-resistant Staphylococcus aureus NRS-1 after 18 hrs by two-fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid. |
| AID1434297 | Cytotoxic activity against human SKOV3 cells assessed as reduction in cell viability after 72 hrs by SRB assay | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Identification of a diverse synthetic abietane diterpenoid library for anticancer activity. |
| AID381368 | Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 500 mol ratio relative to TPA | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6 | Potential antitumor-promoting diterpenoids from the stem bark of Picea glehni. |
| AID381367 | Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 1000 mol ratio relative to TPA | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6 | Potential antitumor-promoting diterpenoids from the stem bark of Picea glehni. |
| AID1355437 | Transactivation of human Gal4-fused RXRbeta LBD expressed in HEK293T cells after 12 to 14 hrs by dual-glo luciferase assay | 2018 | Journal of medicinal chemistry, 06-28, Volume: 61, Issue:12 | Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics. |
| AID1392009 | Antistaphylococcal activity against Staphylococcus aureus Newman after 18 hrs by two-fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid. |
| AID1275096 | Cytotoxic activity against human Bel7404 cells assessed as inhibition of cell growth after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Jan-27, Volume: 108 | Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis. |
| AID1174410 | Cytotoxicity against human MGC803 cells after 48 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Jan-07, Volume: 89 | Design, synthesis and in vitro evaluation of novel dehydroabietic acid derivatives containing a dipeptide moiety as potential anticancer agents. |
| AID1325498 | Antibacterial activity against gentamicin-resistant Staphylococcus aureus NRS-108 | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22 | The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: Modifications at C-12. |
| AID471478 | Antifungal activity against Candida krusei ATCC 6258 at <100 ug/ml after 24 hrs by AFST-EUCAST method | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis and biological evaluation of dehydroabietic acid derivatives. |
| AID774809 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 23, Issue:19 | Synthesis and antitumor activities of novel α-aminophosphonates dehydroabietic acid derivatives. |
| AID1246299 | Cytotoxicity against HEK293 cells at <= 50 uM after 72 hrs by CellTiter-Glo assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | (+)-Dehydroabietylamine derivatives target triple-negative breast cancer. |
| AID1076716 | Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Synthesis and antitumor activities of novel dipeptide derivatives derived from dehydroabietic acid. |
| AID1076721 | Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Synthesis and antitumor activities of novel dipeptide derivatives derived from dehydroabietic acid. |
| AID776387 | Cytotoxicity against human A549 cells after 3 days by MTT assay | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and antitumor activities of novel thiourea α-aminophosphonates from dehydroabietic acid. |
| AID1275099 | Cytotoxic activity against human NCI-H460 cells assessed as inhibition of cell growth after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Jan-27, Volume: 108 | Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis. |
| AID1410144 | Inhibition of SYK (unknown origin) by mobility shift assay | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
| AID332339 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 375 after 18 hrs by microbroth dilution method | 2003 | Journal of natural products, Feb, Volume: 66, Issue:2 | Antibacterial diterpenes from Calceolaria pinifolia. |
| AID1410137 | Inhibition of AKT1 (unknown origin) at 50 ug/ml by mobility shift assay relative to control | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
| AID1174409 | Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Jan-07, Volume: 89 | Design, synthesis and in vitro evaluation of novel dehydroabietic acid derivatives containing a dipeptide moiety as potential anticancer agents. |
| AID776384 | Cytotoxicity against human HepG2 cells after 3 days by MTT assay | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and antitumor activities of novel thiourea α-aminophosphonates from dehydroabietic acid. |
| AID1355438 | Transactivation of human Gal4-fused RXRbeta LBD expressed in HEK293T cells after 12 to 14 hrs by dual-glo luciferase assay relative to bexarotene | 2018 | Journal of medicinal chemistry, 06-28, Volume: 61, Issue:12 | Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics. |
| AID471480 | Antifungal activity against Candida albicans ATCC 10231 at <100 ug/ml after 24 hrs by AFST-EUCAST method | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis and biological evaluation of dehydroabietic acid derivatives. |
| AID471487 | Selectivity index, ratio of IC50 for african green monkey Vero cells to IC50 for human HeLa cells | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis and biological evaluation of dehydroabietic acid derivatives. |
| AID1410129 | Inhibition of BRAF (unknown origin) at 50 ug/ml by Lanthascreen assay relative to control | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. |
| AID457056 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release | 2010 | Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2 | Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr. |
| AID776385 | Cytotoxicity against human SKOV3 cells after 3 days by MTT assay | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and antitumor activities of novel thiourea α-aminophosphonates from dehydroabietic acid. |
| AID1491116 | Toxicity in 7-days post fertilized zebra fish larvae after 1.5 to 24 hrs by microscopic analysis | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5 | HPLC-Based Activity Profiling for GABA |
| AID1295872 | Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Diterpenes from the Trunk of Abies holophylla and Their Potential Neuroprotective and Anti-inflammatory Activities. |
| AID471485 | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis and biological evaluation of dehydroabietic acid derivatives. |
| AID1355456 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability up to 100 uM after 48 hrs by WST1 assay | 2018 | Journal of medicinal chemistry, 06-28, Volume: 61, Issue:12 | Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics. |
| AID398027 | Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 10 mol ratio relative to TPA | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis. |
| AID381369 | Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 100 mol ratio relative to TPA | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6 | Potential antitumor-promoting diterpenoids from the stem bark of Picea glehni. |
| AID1751494 | Antibiofilm activity against Staphylococcus aureus assessed as inhibition of biofilm formation at 60 uM | 2021 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 48 | Discovery of non-proteinogenic amino acids inhibiting biofilm formation by S. aureus and methicillin-resistant S. aureus. |
| AID755527 | Cytotoxicity against human EJ cells assessed as growth inhibition after 72 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13 | Anticancer effects of a novel class rosin-derivatives with different mechanisms. |
| AID1434295 | Cytotoxic activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Identification of a diverse synthetic abietane diterpenoid library for anticancer activity. |
| AID471477 | Antifungal activity against Candida parapsilosis ATCC 22019 at <100 ug/ml after 24 hrs by AFST-EUCAST method | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis and biological evaluation of dehydroabietic acid derivatives. |
| AID457058 | Antiproliferative activity against human LoVo cells | 2010 | Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2 | Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr. |
| AID755553 | Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13 | Anticancer effects of a novel class rosin-derivatives with different mechanisms. |
| AID398028 | Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio after 48 hours relative to TPA | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis. |
| AID774808 | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 23, Issue:19 | Synthesis and antitumor activities of novel α-aminophosphonates dehydroabietic acid derivatives. |
| AID398025 | Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 500 mol ratio relative to TPA | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis. |
| AID1368174 | Antibacterial activity against Staphylococcus aureus measured after 24 hrs | 2017 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 27, Issue:24 | Identification of a diverse synthetic abietane diterpenoid library and insight into the structure-activity relationships for antibacterial activity. |
| AID1076717 | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Synthesis and antitumor activities of novel dipeptide derivatives derived from dehydroabietic acid. |
| AID457055 | Antiproliferative activity against human QGY7703 cells | 2010 | Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2 | Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr. |
| AID1325499 | Antibacterial activity against linezolid-resistant Staphylococcus aureus NRS-271 | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22 | The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: Modifications at C-12. |
| AID1224817 | Assays to identify small molecules inhibitory for eIF4E expression | 2015 | Chemistry & biology, Jul-23, Volume: 22, Issue:7 | Internal Ribosome Entry Site-Based Bicistronic In Situ Reporter Assays for Discovery of Transcription-Targeted Lead Compounds. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 15 (7.14) | 18.7374 |
| 1990's | 30 (14.29) | 18.2507 |
| 2000's | 56 (26.67) | 29.6817 |
| 2010's | 83 (39.52) | 24.3611 |
| 2020's | 26 (12.38) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (36.54) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 5 (2.34%) | 6.00% |
| Case Studies | 1 (0.47%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 208 (97.20%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||