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Urotensin-2 receptor
A urotensin-2 receptor that is encoded in the genome of rat. [OMA:P49684, PRO:DNx]
Synonyms
UR-2-R;
G-protein coupled receptor 14;
G-protein coupled sensory epithelial neuropeptide-like receptor;
SENR;
Urotensin II receptor;
UR-II-R
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| aspirin | Rattus norvegicus (Norway rat) | IC50 | 0.3000 | 1 | 2 |
| celecoxib | Rattus norvegicus (Norway rat) | IC50 | 7.6000 | 1 | 2 |
| act 058362 | Rattus norvegicus (Norway rat) | IC50 | 75.0000 | 1 | 1 |
| sb-611812 | Rattus norvegicus (Norway rat) | Ki | 0.1210 | 1 | 1 |
| sb-706375 | Rattus norvegicus (Norway rat) | IC50 | 0.0340 | 1 | 1 |
| pf 915275 | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 1 |
| urotensin ii | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| melanotan-ii | Rattus norvegicus (Norway rat) | EC50 | 0.0033 | 1 | 1 |
| urotensin ii | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides.Journal of medicinal chemistry, , 02-14, Volume: 62, Issue:3, 2019
Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor.Journal of medicinal chemistry, , Jul-24, Volume: 57, Issue:14, 2014