mocetinostat profile

ID Source	ID
PubMed CID	9865515
CHEMBL ID	272980
SCHEMBL ID	157027
CHEBI ID	94525
MeSH ID	M0514040

Synonym
726169-73-9
n-(2-aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide
HY-12164
peroxidase
9003-99-0
mg-0103
mgcd0103 ,
chembl272980 ,
mgcd-0103
bdbm24624
n-(2-aminophenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide
mg 0103
mgcd 0103
n-(2-aminophenyl)-4-((4-pyridin-3-ylpyrimidin-2-ylamino)methyl)benzamide
mocetinostat
mg0103
n-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide
myeloperoxidase (usan)
D09641
D09643
mocetinostat (usan/inn)
BCP9000925
unii-a6gwb8t96j
mocetinostat [usan:inn]
a6gwb8t96j ,
benzamide, n-(2-aminophenyl)-4-(((4-(3-pyridinyl)-2-pyrimidinyl)amino)methyl)-
BCPP000163
mgcd010,3mocetinostat
NCGC00263182-02
NCGC00263182-01
CS-0502
S1122
mocetinostat [usan]
mocetinostat [who-dd]
mocetinostat [inn]
AKOS016340325
gtpl7008
BRD-K16485616-001-01-4
CCG-208763
smr004701289
MLS006010181
n-(2-aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide;mgcd0103;mocetinostat;mgcd0103(mocetinostat)
SCHEMBL157027
BD-0114
n-(2-aminophenyl)-4-[[[4-(3-pyridyl)pyrimidin-2-yl]amino]methyl]benzamide
DTXSID80222945
n-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide
n-(2-aminophenyl)-4-(((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)benzamide
AC-30281
mocetinostat (mgcd0103)
J-522866
EX-A049
CHEBI:94525
HMS3654K06
HRNLUBSXIHFDHP-UHFFFAOYSA-N
mfcd10565970
NCGC00263182-11
SW218130-2
mgcd0103 (mocetinostat)
DB11830
FT-0741876
Q424869
n-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide
mocetinostat (mgcd-0103)
726169-73-9 (free base)
BCP01814
BRD-K16485616-001-04-8
SB16666
HMS3426I07
FT-0627651
n-(2-aminophenyl)-4-({[4-(3-pyridinyl)-2-pyrimidinyl]amino}methyl)benzamide
AU-004/43508107
nsc760143
nsc-760143

Role	Description
EC 3.5.1.98 (histone deacetylase) inhibitor	An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
antineoplastic agent	A substance that inhibits or prevents the proliferation of neoplasms.
cardioprotective agent	Any protective agent that is able to prevent damage to the heart.
hepatotoxic agent	A role played by a chemical compound exihibiting itself through the ability to induce damage to the liver in animals.
apoptosis inducer	Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
autophagy inducer	Any compound that induces the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).

Class	Description
aminopyrimidine	A member of the class of pyrimidines that is pyrimidine substituted by at least one amino group and its derivatives.
pyridines	Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives.
benzamides
substituted aniline
secondary carboxamide	A carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1).
secondary amino compound	A compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups.

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
PPM1D protein	Homo sapiens (human)	Potency	7.3876	AID1347411
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	0.7564	AID1645841
EWS/FLI fusion protein	Homo sapiens (human)	Potency	1.0884	AID1259252; AID1259253; AID1259255; AID1259256
G	Vesicular stomatitis virus	Potency	5.3547	AID1645842
cytochrome P450 2D6	Homo sapiens (human)	Potency	4.7724	AID1645840
Interferon beta	Homo sapiens (human)	Potency	6.8794	AID1347411; AID1645842
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	5.3547	AID1645842
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	5.3547	AID1645842
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	5.3547	AID1645842

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Histone deacetylase 3	Homo sapiens (human)	IC50	3.4180	AID1201721; AID1241514; AID1740022; AID1798452; AID1798526; AID316931; AID324949; AID344094; AID367305; AID762203; AID780587
Histone deacetylase 3	Homo sapiens (human)	Ki	0.2650	AID496803
Nuclear receptor corepressor 1	Homo sapiens (human)	IC50	0.0220	AID762203
Integrin beta-1	Homo sapiens (human)	IC50	10.0000	AID344099
Cytochrome P450 3A4	Homo sapiens (human)	IC50	0.5700	AID609494
Leukotriene A-4 hydrolase	Homo sapiens (human)	IC50	10.0000	AID1441630; AID1441631
Cytochrome P450 2D6	Homo sapiens (human)	IC50	0.1020	AID708216
Integrin alpha-4	Homo sapiens (human)	IC50	10.0000	AID344099
Cytochrome P450 2C19	Homo sapiens (human)	IC50	0.1020	AID708216
Histone deacetylase 4	Homo sapiens (human)	IC50	6.2287	AID1740024; AID1798452; AID1798526; AID344096; AID440821
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50	30.0000	AID609493; AID613341
Histone deacetylase 1	Homo sapiens (human)	IC50	2.4892	AID1201719; AID1241511; AID1740020; AID1798452; AID1798526; AID1810051; AID1907399; AID316892; AID324948; AID344092; AID367297; AID440819; AID609489; AID708216; AID721037; AID762201; AID780588
Histone deacetylase 1	Homo sapiens (human)	Ki	0.0090	AID496801
Histone deacetylase 7	Homo sapiens (human)	IC50	7.3350	AID1740026; AID1798452; AID344099; AID367308; AID440823
Histone deacetylase 2	Homo sapiens (human)	IC50	3.5691	AID1201720; AID1241513; AID1740021; AID1798452; AID344093; AID367304; AID440820; AID762204; AID780579
Histone deacetylase 2	Homo sapiens (human)	Ki	0.0324	AID496802
Histone deacetylase 11	Homo sapiens (human)	IC50	4.9592	AID1467232; AID1740028; AID1798452; AID344095
Histone deacetylase 8	Homo sapiens (human)	IC50	11.7306	AID1241517; AID1740023; AID1798452; AID316893; AID344100; AID367309; AID762202
Histone deacetylase 6	Homo sapiens (human)	IC50	8.6016	AID1740027; AID1798452; AID1798526; AID1810052; AID316899; AID344098; AID367307; AID708215; AID762205
Histone deacetylase 5	Homo sapiens (human)	IC50	7.3350	AID1740025; AID1798452; AID344097; AID367306; AID440822
Nuclear receptor corepressor 2	Homo sapiens (human)	IC50	0.0450	AID1241514

Assay ID	Title	Year	Journal	Article
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 ISSN: 2472-5560	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347414	qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Secondary screen by immunofluorescence	2020	ACS chemical biology, 07-17, Volume: 15, Issue:7 ISSN: 1554-8937	High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347112	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347102	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1745845	Primary qHTS for Inhibitors of ATXN expression	2022	The Journal of biological chemistry, 08, Volume: 298, Issue:8 ISSN: 1083-351X
AID1347086	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173ISSN: 1872-9096	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347128	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347106	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347091	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347114	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347119	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347108	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347125	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1508630	Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay	2021	Cell reports, 04-27, Volume: 35, Issue:4 ISSN: 2211-1247	A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347127	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347083	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen	2020	Antiviral research, 01, Volume: 173ISSN: 1872-9096	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347116	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347093	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347082	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173ISSN: 1872-9096	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347107	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347154	Primary screen GU AMC qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347123	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347097	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347121	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for control Hh wild type fibroblast cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347122	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347090	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347101	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347109	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347096	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347098	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347100	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347126	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347104	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347115	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347092	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347118	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347089	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347124	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for RD cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347113	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347129	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347117	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347095	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347105	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347099	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347111	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347094	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347110	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells)	2018	Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID708215	Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22 ISSN: 1520-4804	Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.
AID609490	Antiproliferative activity against human HCT116 cells	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 ISSN: 1464-3405	The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
AID721034	Cytotoxicity against human A549 cells after 72 hrs by MTT assay	2013	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1 ISSN: 1464-3405	Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors.
AID316941	Inhibition of HDAC9	2008	Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6 ISSN: 0022-2623	Histone deacetylase inhibitors: from bench to clinic.
AID344378	Volume of distribution at steady state in Beagle dog at 10 mg/kg, iv and 7 to 30 mg/kg, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID762189	Cytotoxicity against human A549 cells assessed as growth inhibition by measuring cellular ATP level after 72 hrs by cell-titer glo assay	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID496803	Inhibition of human HDAC3	2010	Nature chemical biology, Mar, Volume: 6, Issue:3 ISSN: 1552-4469	Chemical phylogenetics of histone deacetylases.
AID762183	Cell cycle arrest in human Jurkat cells assessed as accumulation at sub-G1 phase at 10 uM after 24 hrs by FITC/propidium iodide staining-based FACS flow cytometric analysis (Rvb = 2%)	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID367309	Inhibition of HDAC8	2009	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 ISSN: 1464-3405	SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).
AID1907399	Inhibition of HDAC1 (unknown origin) using trypsin and LGK(Ac)-AMC as substrates incubated for 1 hr and measured by fluorescence assay	2022	European journal of medicinal chemistry, Jun-05, Volume: 236ISSN: 1768-3254	Dual-acting antitumor agents targeting the A
AID344390	Antitumor activity against human DU145 cells xenografted in CD1 nude mouse at 40 mg/kg/day, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID316892	Inhibition of HDAC1	2008	Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6 ISSN: 0022-2623	Histone deacetylase inhibitors: from bench to clinic.
AID708216	Inhibition of human recombinant HDAC1 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate	2012	Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22 ISSN: 1520-4804	Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.
AID762174	Induction of apoptosis in human HeLa cells assessed as PARP cleavage at 1 to 10 uM after 24 hrs by Western blot analysis	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID344124	Clearance in Beagle dog at 10 mg/kg, iv and 7 to 30 mg/kg, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1241542	Induction of cell cycle arrest in human U937 cells assessed as accumulation at S phase at 10 uM incubated for 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 28.2%)	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID316934	Inhibition of HDAC4	2008	Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6 ISSN: 0022-2623	Histone deacetylase inhibitors: from bench to clinic.
AID1441631	Inhibition of recombinant human LTA4H Epoxide Hydrolase expressed in Escherichia coli BL21 (DE3) pLysS preincubated for 10 mins followed by addition of LTA4 as substrate measured after 15 mins by reverse-phase HPLC analysis	2017	Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5 ISSN: 1520-4804	Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
AID316899	Inhibition of HDAC6	2008	Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6 ISSN: 0022-2623	Histone deacetylase inhibitors: from bench to clinic.
AID316936	Inhibition of HDAC7	2008	Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6 ISSN: 0022-2623	Histone deacetylase inhibitors: from bench to clinic.
AID1201731	Cytotoxicity against human SNU16 cells assessed as growth inhibition after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
AID344110	Clearance in CD1 mouse at 2.5 to 15 mg/kg, iv and po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID721035	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	2013	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1 ISSN: 1464-3405	Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors.
AID1241529	Solubility by CLND method	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID1201719	Inhibition of recombinant human HDAC1 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assay	2015	European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
AID344117	Clearance in Sprague-Dawley rat at 2.5 to 5 mg/kg, iv and 2.5 to 50 mg/kg, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1467232	Inhibition of recombinant full length human C-terminal FLAG-tagged HDAC11 expressed in baculovirus infected Sf9 cells using Boc-Lys(epsilon-Ac)-AMC as substrate pretreated for 10 mins followed by substrate addition by fluorometric method	2017	Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13 ISSN: 1464-3405	Stabilizing HDAC11 with SAHA to assay slow-binding benzamide inhibitors.
AID613298	In vitro cardiac safety index, ratio of IC50 for human ERG to IC50 for human HCT116 cells	2011	Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13 ISSN: 1520-4804	Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
AID392407	Inhibition of HDAC1 in human 293T cells after 16 hrs by fluorimetry relative to SAHA	2009	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 ISSN: 1464-3405	Sulfamides as novel histone deacetylase inhibitors.
AID440823	Inhibition of human recombinant N-terminal FLAG-tagged HDAC7 (438-915) expressed in baculovirus after 10 mins by fluorimetric analysis	2009	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19 ISSN: 1464-3405	Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
AID344095	Inhibition of human recombinant HDAC11 homogeneous fluorescence release assay	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID344120	Cmax in Sprague-Dawley rat at 2.5 to 50 mg/kg, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1740025	Inhibition of human NH2-terminal His6-tagged HDAC5 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorometry	2020	Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 ISSN: 1520-4804	Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
AID1241531	Binding affinity to human serum albumin	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID1441700	Inhibition of recombinant human LTA4H Epoxide Hydrolase expressed in Escherichia coli BL21 (DE3) pLysS at 10 uM preincubated for 10 mins followed by addition of LTA4 as substrate measured after 15 mins by reverse-phase HPLC analysis	2017	Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5 ISSN: 1520-4804	Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
AID367302	Induction of p21WAF1/CIP1 expression in human HCT116 cells assessed as tubulin level after 16 hrs by luciferase assay	2009	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 ISSN: 1464-3405	SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).
AID344098	Inhibition of human recombinant HDAC6 homogeneous fluorescence release assay	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID316931	Inhibition of HDAC3	2008	Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6 ISSN: 0022-2623	Histone deacetylase inhibitors: from bench to clinic.
AID1241527	Lipophilicity, log P of the compound	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID1241535	Inhibition of HDAC in human PC3 cells assessed as reduction in cyclin E expression in at 10 uM incubated for 24 hrs by Western blotting method	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID496802	Inhibition of human HDAC2	2010	Nature chemical biology, Mar, Volume: 6, Issue:3 ISSN: 1552-4469	Chemical phylogenetics of histone deacetylases.
AID721037	Inhibition of HDAC1 (unknown origin)	2013	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1 ISSN: 1464-3405	Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors.
AID440820	Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus after 10 mins by fluorimetric analysis	2009	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19 ISSN: 1464-3405	Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
AID1740021	Inhibition of human C-terminal Flag-tagged HDAC2 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorometry	2020	Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 ISSN: 1520-4804	Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
AID609497	Half life in rat liver microsomes	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 ISSN: 1464-3405	The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
AID344096	Inhibition of human recombinant HDAC4 homogeneous fluorescence release assay	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1441630	Inhibition of recombinant human LTA4H aminopeptidase activity expressed in Escherichia coli BL21 (DE3) pLysS assessed as formation of p-NA from Ala-p-NA preincubated for 10 mins followed by substrate addition measured after 10 mins	2017	Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5 ISSN: 1520-4804	Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
AID762181	Cell cycle arrest in human Jurkat cells assessed as accumulation at S phase at 10 uM after 24 hrs by FITC/propidium iodide staining-based FACS flow cytometric analysis (Rvb = 15.3%)	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID1201734	Cytotoxicity against human SJSA1 cells assessed as growth inhibition after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
AID1241513	Inhibition of His-tagged recombinant HDAC2 (1 to 488 residues) (unknown origin) pre-incubated for 3 hrs before substrate addition by homogeneous fluorogenic HDAC assay	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID762173	Induction of apoptosis in human Jurkat cells assessed as PARP cleavage at 1 to 10 uM after 24 hrs by Western blot analysis	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID762204	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID316935	Inhibition of HDAC5	2008	Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6 ISSN: 0022-2623	Histone deacetylase inhibitors: from bench to clinic.
AID762188	Cytotoxicity against human HCT116 cells assessed as growth inhibition by measuring cellular ATP level after 72 hrs by cell-titer glo assay	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID1907401	Antiproliferative activity against mouse CT26 cells after 72 hrs by CCK-8 assay	2022	European journal of medicinal chemistry, Jun-05, Volume: 236ISSN: 1768-3254	Dual-acting antitumor agents targeting the A
AID1241541	Induction of cell cycle arrest in human U937 cells assessed as accumulation at G0/G1 phase at 10 uM incubated for 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 56.1%)	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID1241537	Induction of cell cycle arrest in human PC3 cells assessed as accumulation at G0/G1 phase at 10 uM incubated for 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 65.5%)	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID1241533	Inhibition of HDAC3 in human PC3 cells assessed as increase in histone H3 lysine-9 acetylation at 10 uM incubated for 24 hrs by Western blotting method	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID344379	Tmax in Beagle dog at 7 to 30 mg/kg, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1201729	Cytotoxicity against human MHCC97H cells assessed as growth inhibition after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
AID324952	Inhibition of HDAC4 H976Y mutant expressed in Escherichia coli at 5 uM	2008	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6 ISSN: 1464-3405	Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
AID344093	Inhibition of human recombinant HDAC2 homogeneous fluorescence release assay	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1241539	Induction of cell cycle arrest in human PC3 cells assessed as accumulation at G2/M phase at 10 uM incubated for 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 11.9%)	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID324954	Inhibition of wild type HDAC4 expressed in Escherichia coli at 10 uM	2008	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6 ISSN: 1464-3405	Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
AID344105	Induction of H3 histone acetylation in human T24 cells relative to MS275	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID344118	Volume of distribution at steady state in Sprague-Dawley rat at 2.5 to 5 mg/kg, iv and 2.5 to 50 mg/kg, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1241511	Inhibition of C-flagged recombinant HDAC1 (unknown origin) pre-incubated for 1 hr before substrate addition by homogeneous fluorogenic HDAC assay	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID344387	Antitumor activity against human A431 cells xenografted in CD1 nude mouse at 90 mg/kg/day, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID762177	Cell cycle arrest in human Jurkat cells assessed as accumulation at S phase at 1 uM after 24 hrs by FITC/propidium iodide staining-based FACS flow cytometric analysis (Rvb = 22.3%)	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID344123	Half life in Beagle dog at 10 mg/kg, iv	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID344386	Antitumor activity against human A431 cells xenografted in CD1 nude mouse at 60 mg/kg/day, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID344108	Induction of apoptosis in HCT116 cells at 1 uM	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1241543	Induction of cell cycle arrest in human U937 cells assessed as accumulation at G2/M phase at 10 uM incubated for 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 15.4%)	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID344114	AUC in CD1 mouse at 2.5 to 15 mg/kg, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1441699	Inhibition of recombinant human LTA4H aminopeptidase activity expressed in Escherichia coli BL21 (DE3) pLysS assessed as formation of p-NA from Ala-p-NA at 10 uM preincubated for 10 mins followed by substrate addition measured after 10 mins	2017	Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5 ISSN: 1520-4804	Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
AID344099	Inhibition of human recombinant HDAC7 homogeneous fluorescence release assay	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1241538	Induction of cell cycle arrest in human PC3 cells assessed as accumulation at S phase at 10 uM incubated for 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 22.4%)	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID1740026	Inhibition of human NH2-terminal His6-tagged HDAC7 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorometry	2020	Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 ISSN: 1520-4804	Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
AID344101	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1907400	Antiproliferative activity against mouse MC38 cells after 72 hrs by CCK-8 assay	2022	European journal of medicinal chemistry, Jun-05, Volume: 236ISSN: 1768-3254	Dual-acting antitumor agents targeting the A
AID1241528	Distribution coefficient, log D of the compound by HPLC method	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID1201720	Inhibition of recombinant human HDAC2 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assay	2015	European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
AID344115	Oral bioavailability in CD1 mouse at 2.5 to 15 mg/kg	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID609498	Half life in human liver microsomes	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 ISSN: 1464-3405	The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
AID324949	Inhibition of HDAC3 in HEK293 cells	2008	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6 ISSN: 1464-3405	Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
AID1740027	Inhibition of human NH2-terminal His-tagged HDAC6 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorometry	2020	Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 ISSN: 1520-4804	Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
AID762205	Inhibition of recombinant His-tagged HDAC6 (unknown origin) using Fluor-de-Lys SIRT1 as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID344097	Inhibition of human recombinant HDAC5 homogeneous fluorescence release assay	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID780587	Inhibition of human recombinant HDAC3 expressed in baculovirus infected insect high5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate after 3 to 24 hrs by fluorescence assay	2013	Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 ISSN: 1464-3391	The discovery and optimization of novel dual inhibitors of topoisomerase II and histone deacetylase.
AID316898	Inhibition of HDAC2	2008	Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6 ISSN: 0022-2623	Histone deacetylase inhibitors: from bench to clinic.
AID344092	Inhibition of human recombinant HDAC1 homogeneous fluorescence release assay	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID613343	Inhibition of human ERG at 30 uM	2011	Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13 ISSN: 1520-4804	Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
AID344392	Antitumor activity against human DU145 cells xenografted in CD1 nude mouse at 80 mg/kg	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1201726	Cytotoxicity against human SW620 cells assessed as growth inhibition after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
AID1241540	Induction of apoptosis in human U937 cells assessed as accumulation at subG1 phase at 10 uM incubated for 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 0.3%)	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID1740024	Inhibition of human NH2-terminal His6-tagged HDAC4 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorometry	2020	Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 ISSN: 1520-4804	Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
AID762184	Inhibition of HDAC in human HeLa cells assessed as increase in H3K9Ac level at 1 to 10 uM after 24 hrs by Western blot analysis	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID344094	Inhibition of human recombinant HDAC3 homogeneous fluorescence release assay	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID344102	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID780581	Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay	2013	Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 ISSN: 1464-3391	The discovery and optimization of novel dual inhibitors of topoisomerase II and histone deacetylase.
AID613295	Antiproliferative activity against human HCT116 cells assessed as growth inhibition	2011	Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13 ISSN: 1520-4804	Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
AID367298	Antiproliferative activity against human HCT116 cells by MTT assay	2009	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 ISSN: 1464-3405	SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).
AID1241530	Permeability by artificial membrane permeability assay	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID721036	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	2013	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1 ISSN: 1464-3405	Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors.
AID1740023	Inhibition of human NH2-terminal His-tagged HDAC8 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorometry	2020	Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 ISSN: 1520-4804	Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
AID762203	Inhibition of recombinant HDAC3-NCoR1 (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID367308	Inhibition of HDAC7	2009	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 ISSN: 1464-3405	SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).
AID613341	Inhibition of human ERG by automated Q-patch assay	2011	Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13 ISSN: 1520-4804	Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
AID1241532	Inhibition of HDAC3 in human U937 cells assessed as increase in histone H3 lysine-9 acetylation at 10 uM incubated for 24 hrs by Western blotting method	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID344100	Inhibition of human recombinant HDAC8 homogeneous fluorescence release assay	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID344381	AUC in Beagle dog at 7 to 30 mg/kg, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID344113	Cmax in CD1 mouse at 2.5 to 15 mg/kg, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1740022	Inhibition of human C-terminal Flag-tagged HDAC3 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorometry	2020	Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 ISSN: 1520-4804	Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
AID762201	Inhibition of recombinant C-terminal FLAG-tagged HDAC1 (unknown origin) expressed in Escherichia coli BL21 using MAL as substrate incubated for 1 hr prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID344109	Half life in CD1 mouse at 2.5 to 15 mg/kg, iv	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1810050	Antiproliferative activity against mouse MC38 cells measured after 72 hrs by CCK8 assay	2021	Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22 ISSN: 1520-4804
AID1241536	Induction of apoptosis in human PC3 cells assessed as accumulation at subG1 phase at 10 uM incubated for 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 0.2%)	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID367304	Inhibition of HDAC2	2009	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 ISSN: 1464-3405	SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).
AID613340	Antiproliferative activity against human H1299 cells	2011	Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13 ISSN: 1520-4804	Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
AID609495	Ratio of IC50 for CYP3A4 to IC50 for human HCT116 cells	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 ISSN: 1464-3405	The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
AID344112	Tmax in CD1 mouse at 2.5 to 15 mg/kg, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID344388	Antitumor activity against human A549 cells xenografted in CD1 nude mouse at 40 mg/kg/day, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID609489	Inhibition of purified recombinant HDAC1	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 ISSN: 1464-3405	The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
AID344106	Induction of p21cip/waf1 protein expression in human HCT116 cells relative to MS275	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID762180	Cell cycle arrest in human Jurkat cells assessed as accumulation at G2/M phase at 10 uM after 24 hrs by FITC/propidium iodide staining-based FACS flow cytometric analysis (Rvb = 13.2%)	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID1241516	Inhibition of His-flagged recombinant HDAC6 (unknown origin) at 20 uM pre-incubated for 1 hr before substrate addition by homogeneous fluorogenic HDAC assay	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID1201721	Inhibition of recombinant human HDAC3 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate after 3 hrs by fluorescence assay	2015	European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
AID1201724	Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
AID762176	Cell cycle arrest in human Jurkat cells assessed as accumulation at G2/M phase at 1 uM after 24 hrs by FITC/propidium iodide staining-based FACS flow cytometric analysis (Rvb = 14.4%)	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID1201728	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
AID344382	Oral bioavailability in Beagle dog at 7 to 30 mg/kg	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1441632	Binding affinity to recombinant human LTA4H hydrolase assessed as change in melting temperature at 50 uM by SYPRO orange dye-based thermofluor assay	2017	Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5 ISSN: 1520-4804	Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
AID762178	Cell cycle arrest in human Jurkat cells assessed as accumulation at G0/G1 phase at 1 uM after 24 hrs by FITC/propidium iodide staining-based FACS flow cytometric analysis (Rvb = 55.5%)	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID1810053	Displacement of [3H]SCH58261 from adenosine A2A receptor membrane (unknown origin) measured after 60 mins by scintillation counting analysis	2021	Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22 ISSN: 1520-4804
AID721023	Oral bioavailability in rat	2013	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1 ISSN: 1464-3405	Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors.
AID762187	Cytotoxicity against human DU145 cells assessed as growth inhibition by measuring cellular ATP level after 72 hrs by cell-titer glo assay	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID344111	Volume of distribution in CD1 mouse at 2.5 to 15 mg/kg, iv and po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID762186	Cytotoxicity against human MCF7 cells assessed as growth inhibition by measuring cellular ATP level after 72 hrs by cell-titer glo assay	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID1891409	Inhibition of SARS-CoV-2 main protease expressed in Escherichia coli using DABCYL-KTSAVLQ1SGFRKM-E(EDANS)-NH2 peptide as substrate at 100 uM incubated for 30 mins by FRET based assay relative to control	2022	Bioorganic & medicinal chemistry letters, 06-15, Volume: 66ISSN: 1464-3405
AID780585	Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay	2013	Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 ISSN: 1464-3391	The discovery and optimization of novel dual inhibitors of topoisomerase II and histone deacetylase.
AID496801	Inhibition of human HDAC1	2010	Nature chemical biology, Mar, Volume: 6, Issue:3 ISSN: 1552-4469	Chemical phylogenetics of histone deacetylases.
AID367301	Induction of histone H4 hyperacetylation in human T24 cells after 16 hrs by immunoblotting	2009	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 ISSN: 1464-3405	SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).
AID762185	Inhibition of HDAC in human Jurkat cells assessed as increase in H3K9Ac level at 1 to 10 uM after 24 hrs by Western blot analysis	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID367305	Inhibition of HDAC3	2009	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 ISSN: 1464-3405	SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).
AID344104	Antiproliferative activity against HMEC after 72 hrs by MTT assay	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID440821	Inhibition of human recombinant N-terminal FLAG-tagged HDAC4 (612-1034) expressed in baculovirus after 10 mins by fluorimetric analysis	2009	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19 ISSN: 1464-3405	Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
AID762202	Inhibition of recombinant HDAC8 (unknown origin) expressed in Escherichia coli BL21 using MAL as substrate incubated for 15 mins prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID762182	Cell cycle arrest in human Jurkat cells assessed as accumulation at G0/G1 phase at 10 uM after 24 hrs by FITC/propidium iodide staining-based FACS flow cytometric analysis (Rvb = 69.5%)	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID344380	Cmax in Beagle dog at 7 to 30 mg/kg, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID344116	Half life in Sprague-Dawley rat at 2.5 to 5 mg/kg, iv	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID367307	Inhibition of HDAC6	2009	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 ISSN: 1464-3405	SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).
AID316893	Inhibition of HDAC8	2008	Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6 ISSN: 0022-2623	Histone deacetylase inhibitors: from bench to clinic.
AID721024	Oral bioavailability in mouse	2013	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1 ISSN: 1464-3405	Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors.
AID1241517	Inhibition of His-flagged recombinant HDAC8 (unknown origin) expressed in Escherichia coli BL21 pre-incubated for 15 mins before substrate addition by homogeneous fluorogenic HDAC assay	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID344122	Oral bioavailability in Sprague-Dawley rat at 2.5 to 50 mg/kg	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID762179	Cell cycle arrest in human Jurkat cells assessed as accumulation at sub-G1 phase at 1 uM after 24 hrs by FITC/propidium iodide staining-based FACS flow cytometric analysis (Rvb = 6.8%)	2013	Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 ISSN: 1520-4804	Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
AID344107	Cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID324948	Inhibition of HDAC1 in HEK293 cells	2008	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6 ISSN: 1464-3405	Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
AID1201725	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
AID1740020	Inhibition of human C-terminal Flag-tagged HDAC1 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorometry	2020	Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 ISSN: 1520-4804	Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
AID1740028	Inhibition of human C-terminal Flag-tagged HDAC11 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorometry	2020	Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 ISSN: 1520-4804	Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
AID780580	Inhibition of Topoisomerase 2 (unknown origin) assessed as impairment of pBR322 DNA decatenation at 100 uM after 30 mins by agarose gel electrophoresis	2013	Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 ISSN: 1464-3391	The discovery and optimization of novel dual inhibitors of topoisomerase II and histone deacetylase.
AID1241514	Inhibition of recombinant HDAC3/NCOR2 (unknown origin) pre-incubated for 3 hrs before substrate addition by homogeneous fluorogenic HDAC assay	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID609493	Inhibition of human ERG by automated patch clamp assay	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 ISSN: 1464-3405	The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
AID324958	Inhibition of HDAC6 in HEK293 cells at 2 uM	2008	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6 ISSN: 1464-3405	Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
AID1810051	Inhibition of HDAC1 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader	2021	Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22 ISSN: 1520-4804
AID344389	Antitumor activity against human A549 cells xenografted in CD1 nude mouse at 60 mg/kg/day, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID344391	Antitumor activity against human DU145 cells xenografted in CD1 nude mouse at 70 mg/kg/day, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1201727	Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
AID609494	Inhibition of CYP3A4	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 ISSN: 1464-3405	The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
AID367306	Inhibition of HDAC5	2009	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 ISSN: 1464-3405	SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).
AID1201730	Cytotoxicity against human SNU5 cells assessed as growth inhibition after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
AID1241534	Inhibition of HDAC in human U937 cells assessed as reduction in cyclin E expression in at 10 uM incubated for 24 hrs by Western blotting method	2015	Journal of medicinal chemistry, Sep-10, Volume: 58, Issue:17 ISSN: 1520-4804	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
AID1810052	Inhibition of HDAC6 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader	2021	Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22 ISSN: 1520-4804
AID367297	Inhibition of human recombinant HDAC1	2009	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 ISSN: 1464-3405	SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).
AID609496	Cardiac safety index, Ratio of IC50 for human ERG to IC50 for human HCT116 cells	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 ISSN: 1464-3405	The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
AID1810049	Antiproliferative activity against mouse CT26 cells measured after 72 hrs by CCK8 assay	2021	Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22 ISSN: 1520-4804
AID367299	Antiproliferative activity against HMEC by MTT assay	2009	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 ISSN: 1464-3405	SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).
AID1201732	Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
AID1201733	Cytotoxicity against human PANC1 cells assessed as growth inhibition after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
AID440822	Inhibition of human recombinant N-terminal FLAG-tagged HDAC5 (620-1122) expressed in baculovirus after 10 mins by fluorimetric analysis	2009	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19 ISSN: 1464-3405	Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
AID440819	Inhibition of recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus after 10 mins by fluorimetric analysis	2009	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19 ISSN: 1464-3405	Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
AID344103	Antiproliferative activity against human Du145 cells after 72 hrs by MTT assay	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID344119	Tmax in Sprague-Dawley rat at 2.5 to 50 mg/kg, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID344121	AUC in Sprague-Dawley rat at 2.5 to 50 mg/kg, po	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID780588	Inhibition of human recombinant HDAC1 expressed in baculovirus infected insect high5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate after 3 to 24 hrs by fluorescence assay	2013	Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 ISSN: 1464-3391	The discovery and optimization of novel dual inhibitors of topoisomerase II and histone deacetylase.
AID609492	Thermodynamic solubility of the compound at pH 6.8	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 ISSN: 1464-3405	The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
AID780579	Inhibition of HDAC2 (unknown origin)	2013	Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 ISSN: 1464-3391	The discovery and optimization of novel dual inhibitors of topoisomerase II and histone deacetylase.
AID686947	qHTS for small molecule inhibitors of Yes1 kinase: Primary Screen	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15 ISSN: 1464-3405	Identification of potent Yes1 kinase inhibitors using a library screening approach.
AID1745855	NCATS anti-infectives library activity on the primary C. elegans qHTS viability assay	2023	Disease models & mechanisms, 03-01, Volume: 16, Issue:3 ISSN: 1754-8411	In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
AID1347412	qHTS assay to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Counter screen cell viability and HiBit confirmation	2020	ACS chemical biology, 07-17, Volume: 15, Issue:7 ISSN: 1554-8937	High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1745854	NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C. elegans viability qHTS	2023	Disease models & mechanisms, 03-01, Volume: 16, Issue:3 ISSN: 1754-8411	In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
AID1347411	qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary	2020	ACS chemical biology, 07-17, Volume: 15, Issue:7 ISSN: 1554-8937	High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1798452	HDAC Enzyme Inhibition Assay from Article 10.1021/jm800251w: \\Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.\\	2008	Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 ISSN: 1520-4804	Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.
AID1798526	HDAC Activity Assay from Article 10.1016/j.bmcl.2008.02.025: \\Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.\\	2008	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6 ISSN: 1464-3405	Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
AID1346134	Human histone deacetylase 1 (3.5.1.- Histone deacetylases (HDACs))	2010	Nature chemical biology, Mar, Volume: 6, Issue:3 ISSN: 1552-4469	Chemical phylogenetics of histone deacetylases.
AID1346077	Human histone deacetylase 3 (3.5.1.- Histone deacetylases (HDACs))	2010	Nature chemical biology, Mar, Volume: 6, Issue:3 ISSN: 1552-4469	Chemical phylogenetics of histone deacetylases.
AID1346082	Human histone deacetylase 2 (3.5.1.- Histone deacetylases (HDACs))	2010	Nature chemical biology, Mar, Volume: 6, Issue:3 ISSN: 1552-4469	Chemical phylogenetics of histone deacetylases.

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2162 (10.35)	18.7374
1990's	3425 (16.39)	18.2507
2000's	5967 (28.56)	29.6817
2010's	7386 (35.35)	24.3611
2020's	1955 (9.36)	2.80

Publication Type	This drug (%)	All Drugs (%)
Trials	390 (1.79%)	5.53%
Reviews	870 (4.00%)	6.00%
Case Studies	760 (3.50%)	4.05%
Observational	53 (0.24%)	0.25%
Other	19,662 (90.46%)	84.16%

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
cytosine	6	aminopyrimidine; pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1997	2021	14.2	low	0	0	2	1	1	2
toxopyrimidine	0	aminopyrimidine; aromatic primary alcohol	Escherichia coli metabolite; Saccharomyces cerevisiae metabolite	0	0		low	0	0	0	0	0	0
benphothiamine	0	aminopyrimidine; formamides; organic phosphate; thioester	antioxidant; immunological adjuvant; nutraceutical; protective agent; provitamin B1	0	0		low	0	0	0	0	0	0
flucytosine	0	aminopyrimidine; nucleoside analogue; organofluorine compound; pyrimidine antifungal drug; pyrimidone	prodrug	0	0		low	0	0	0	0	0	0
pyrimethamine	1	aminopyrimidine; monochlorobenzenes	antimalarial; antiprotozoal drug; EC 1.5.1.3 (dihydrofolate reductase) inhibitor	2019	2019	5.0	low	0	0	0	0	1	0
sb 220025	0	aminopyrimidine; imidazoles; organofluorine compound; piperidines	angiogenesis inhibitor; anti-inflammatory agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	0	0		low	0	0	0	0	0	0
trimethoprim	1	aminopyrimidine; methoxybenzenes	antibacterial drug; diuretic; drug allergen; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; environmental contaminant; xenobiotic	1999	1999	25.0	low	0	0	1	0	0	0
2-aminopyrimidine	0	aminopyrimidine		0	0		low	0	0	0	0	0	0
2-amino-4,6-dimethyl pyrimidine	0	aminopyrimidine		0	0		low	0	0	0	0	0	0
2,4,6-triaminopyrimidine	0	aminopyrimidine		0	0		low	0	0	0	0	0	0
diaveridine	0	aminopyrimidine	antiparasitic agent; drug allergen	0	0		low	0	0	0	0	0	0
2-amino-4-chloro-6-methylpyrimidine	0	aminopyrimidine	nitrification inhibitor	0	0		low	0	0	0	0	0	0
pirimicarb	0	aminopyrimidine; carbamate ester; tertiary amino compound	agrochemical; carbamate insecticide; EC 3.1.1.7 (acetylcholinesterase) inhibitor; environmental contaminant; insecticide; xenobiotic	0	0		low	0	0	0	0	0	0
pirimiphos methyl	0	aminopyrimidine; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; environmental contaminant; insecticide	0	0		low	0	0	0	0	0	0
bupirimate	0	aminopyrimidine; pyrimidine fungicide; secondary amino compound; sulfamate ester	androgen antagonist; antifungal agrochemical	0	0		low	0	0	0	0	0	0
nimustine	0	aminopyrimidine; N-nitrosoureas; organochlorine compound	alkylating agent; antineoplastic agent	0	0		low	0	0	0	0	0	0
isocytosine	0	aminopyrimidine; pyrimidine nucleobase; pyrimidone		0	0		low	0	0	0	0	0	0
2,4-diaminopyrimidine	0	aminopyrimidine		0	0		low	0	0	0	0	0	0
brodimoprim	0	aminopyrimidine; bromobenzenes; methoxybenzenes	antibacterial drug; antiinfective agent; EC 1.5.1.3 (dihydrofolate reductase) inhibitor	0	0		low	0	0	0	0	0	0
4-aminopyrimidine	0	aminopyrimidine		0	0		low	0	0	0	0	0	0
5-hydroxymethylcytosine	0	aminopyrimidine; aromatic primary alcohol; nucleobase analogue; pyrimidone	human metabolite; mouse metabolite	0	0		low	0	0	0	0	0	0
isaxonine	0	aminopyrimidine		0	0		low	0	0	0	0	0	0
sofosbuvir	0	aminopyrimidine; aromatic carboxylic acid; nucleobase analogue; pyrimidone	metabolite	0	0		low	0	0	0	0	0	0
1-methylcytosine	0	aminopyrimidine; methylcytosine; pyrimidone	metabolite	0	0		low	0	0	0	0	0	0
mepanipyrim	0	acetylenic compound; aminopyrimidine; anilinopyrimidine fungicide; secondary amino compound	antifungal agrochemical; aryl hydrocarbon receptor agonist; hepatotoxic agent	0	0		low	0	0	0	0	0	0
cyprodinil	0	aminopyrimidine; anilinopyrimidine fungicide; cyclopropanes; secondary amino compound	antifungal agrochemical; aryl hydrocarbon receptor agonist; environmental contaminant; xenobiotic	0	0		low	0	0	0	0	0	0
pyrimethanil	0	aminopyrimidine; anilinopyrimidine fungicide; secondary amino compound	antifungal agrochemical; aryl hydrocarbon receptor agonist; environmental contaminant; xenobiotic	0	0		low	0	0	0	0	0	0
4,6-diamino-5-n-formamidopyrimidine	0	aminopyrimidine; formamidopyrimidine		0	0		low	0	0	0	0	0	0
n(4)-methylcytosine	0	aminopyrimidine; methylcytosine; pyrimidone	metabolite	0	0		low	0	0	0	0	0	0
3-methylcytosine	0	aminopyrimidine; methylcytosine; pyrimidone	metabolite	0	0		low	0	0	0	0	0	0
4-amino-2-methoxypyrimidine	0	aminopyrimidine; aromatic ether; methylcytosine	metabolite	0	0		low	0	0	0	0	0	0
etravirine	0	aminopyrimidine; aromatic ether; dinitrile; organobromine compound	antiviral agent; HIV-1 reverse transcriptase inhibitor	0	0		low	0	0	0	0	0	0
iclaprim	0	aminopyrimidine; chromenes; cyclopropanes		0	0		low	0	0	0	0	0	0
nsc 23766	0	aminopyrimidine; aminoquinoline; primary amino compound; secondary amino compound; tertiary amino compound	antiviral agent; apoptosis inducer; EC 3.6.5.2 (small monomeric GTPase) inhibitor; muscarinic antagonist	0	0		low	0	0	0	0	0	0
2-(3,5-dimethyl-1-pyrazolyl)-N,6-dimethyl-4-pyrimidinamine	0	aminopyrimidine		0	0		low	0	0	0	0	0	0
2-[[2-(3,5-dimethyl-1-pyrazolyl)-6-methyl-4-pyrimidinyl]amino]ethanol	0	aminopyrimidine		0	0		low	0	0	0	0	0	0
4-methyl-6-(2,2,3,3,4,4,5,5-octafluoropentoxy)-2-pyrimidinamine	0	aminopyrimidine		0	0		low	0	0	0	0	0	0
7-methylpyrimido[4,5-d]pyrimidin-4-amine	0	aminopyrimidine		0	0		low	0	0	0	0	0	0
4-(5-methyl-3-phenylisoxazol-4-yl)pyrimidin-2-amine	0	aminopyrimidine; isoxazoles		0	0		low	0	0	0	0	0	0
thiamine disulfide	0	aminopyrimidine; formamides; homoallylic alcohol; organic disulfide		0	0		low	0	0	0	0	0	0
dasatinib	1	1,3-thiazoles; aminopyrimidine; monocarboxylic acid amide; N-(2-hydroxyethyl)piperazine; N-arylpiperazine; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor	2016	2016	8.0	low	0	0	0	0	1	0
4-(2-furanyl)-N-(3-pyridinylmethyl)-6-(trifluoromethyl)-2-pyrimidinamine	0	aminopyrimidine		0	0		low	0	0	0	0	0	0
annomontine	0	alkaloid; aminopyrimidine; beta-carbolines	antiparasitic agent; metabolite	0	0		low	0	0	0	0	0	0
rilpivirine	0	aminopyrimidine; nitrile	EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor; HIV-1 reverse transcriptase inhibitor	0	0		low	0	0	0	0	0	0
chir 99021	0	aminopyridine; aminopyrimidine; cyanopyridine; diamine; dichlorobenzene; imidazoles; secondary amino compound	EC 2.7.11.26 (tau-protein kinase) inhibitor	0	0		low	0	0	0	0	0	0
pazopanib	0	aminopyrimidine; indazoles; sulfonamide	angiogenesis modulating agent; antineoplastic agent; tyrosine kinase inhibitor; vascular endothelial growth factor receptor antagonist	0	0		low	0	0	0	0	0	0
5-formylcytosine	0	aminopyrimidine; heteroarenecarbaldehyde; nucleobase analogue; pyrimidone	metabolite	0	0		low	0	0	0	0	0	0
bay 63-2521	0	aminopyrimidine; carbamate ester; organofluorine compound; pyrazolopyridine	antihypertensive agent; soluble guanylate cyclase activator	0	0		low	0	0	0	0	0	0
4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3h-imidazol-4-yl)pyrimidin-2-ylamine	0	aminopyrimidine; imidazoles; monofluorobenzenes	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor	0	0		low	0	0	0	0	0	0
bay 60-4552	0	aminopyrimidine; carbamate ester; monofluorobenzenes; pyrazolopyridine	antihypertensive agent; drug metabolite; soluble guanylate cyclase activator; vasodilator agent	0	0		low	0	0	0	0	0	0
2-({2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl}amino)benzamide	0	aminopyrimidine; benzamides	protein kinase inhibitor	0	0		low	0	0	0	0	0	0
buparlisib	0	aminopyridine; aminopyrimidine; morpholines; organofluorine compound	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor	0	0		low	0	0	0	0	0	0
n-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide	0	aminopyrimidine; benzamides; morpholines; nitrile; secondary amino compound; tertiary amino compound	anti-anaemic agent; antineoplastic agent; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor	0	0		low	0	0	0	0	0	0
TAK-580	0	1,3-thiazolecarboxamide; aminopyrimidine; chloropyridine; organofluorine compound; pyrimidinecarboxamide; secondary carboxamide	antineoplastic agent; apoptosis inducer; B-Raf inhibitor	0	0		low	0	0	0	0	0	0
dabrafenib	0	1,3-thiazoles; aminopyrimidine; organofluorine compound; sulfonamide	anticoronaviral agent; antineoplastic agent; B-Raf inhibitor	0	0		low	0	0	0	0	0	0
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea	0	aminopyrimidine; dichlorobenzene; N-alkylpiperazine; N-arylpiperazine; phenylureas	antineoplastic agent; fibroblast growth factor receptor antagonist	0	0		low	0	0	0	0	0	0
chir 98014	0	aminopyrimidine; C-nitro compound; diaminopyridine; dichlorobenzene; imidazoles; secondary amino compound	antineoplastic agent; apoptosis inducer; EC 2.7.11.26 (tau-protein kinase) inhibitor; hypoglycemic agent; tau aggregation inhibitor; Wnt signalling activator	0	0		low	0	0	0	0	0	0
vericiguat	0	aminopyrimidine; carbamate ester; organofluorine compound; pyrazolopyridine	antihypertensive agent; soluble guanylate cyclase activator; vasodilator agent	0	0		low	0	0	0	0	0	0
AZD3463	0	aminopiperidine; aminopyrimidine; indoles; monomethoxybenzene; organochlorine compound; secondary amino compound; tertiary amino compound	antineoplastic agent; apoptosis inducer; autophagy inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	0	0		low	0	0	0	0	0	0
ceritinib	0	aminopyrimidine; aromatic ether; organochlorine compound; piperidines; secondary amino compound; sulfone	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	0	0		low	0	0	0	0	0	0
HG-10-102-01	0	aminopyrimidine; aromatic ether; monocarboxylic acid amide; morpholines; organochlorine compound; secondary amino compound	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor	0	0		low	0	0	0	0	0	0
osimertinib	0	acrylamides; aminopyrimidine; biaryl; indoles; monomethoxybenzene; secondary amino compound; secondary carboxamide; substituted aniline; tertiary amino compound	antineoplastic agent; epidermal growth factor receptor antagonist	0	0		low	0	0	0	0	0	0
hg-9-91-01	0	aminopyrimidine; dimethoxybenzene; N-alkylpiperazine; N-arylpiperazine; phenylureas; secondary amino compound	antineoplastic agent; salt-inducible kinase 2 inhibitor	0	0		low	0	0	0	0	0	0
praliciguat	0	aminopyrimidine; isoxazoles; monofluorobenzenes; organofluorine compound; pyrazoles; secondary amino compound; tertiary alcohol	anti-inflammatory agent; antihypertensive agent; soluble guanylate cyclase activator; vasodilator agent	0	0		low	0	0	0	0	0	0
THZ531	0	aminopyrimidine; enamide; indoles; N-acylpiperidine; organochlorine compound; secondary amino compound; secondary carboxamide	antineoplastic agent; apoptosis inducer; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor	0	0		low	0	0	0	0	0	0
n(5)-methyl-n(5)-formyl-2,5,6-triamino-4-hydroxypyrimidine	0	aminopyrimidine; formamidopyrimidine; hydroxypyrimidine		0	0		low	0	0	0	0	0	0
2-amino-6-methylpyrimidin-4-one	0	aminopyrimidine; hydroxypyrimidine; pyrimidone		0	0		low	0	0	0	0	0	0
6-hydroxy-2,4,5-triaminopyrimidine	0	aminopyrimidine; hydroxypyrimidine	antioxidant; chromophore	0	0		low	0	0	0	0	0	0
ethirimol	0	aminopyrimidine; pyrimidine fungicide; pyrimidone; secondary amino compound	antifungal agrochemical	0	0		low	0	0	0	0	0	0
3-cyanopyridine	0	nitrile; pyridines		0	0		low	0	0	0	0	0	0
2-(3-pyridine)acetic acid	0	monocarboxylic acid; pyridines	human xenobiotic metabolite	0	0		low	0	0	0	0	0	0
nicotine 1-n-oxide	0	pyridines; pyrrolidine N-oxides		0	0		low	0	0	0	0	0	0
norcotinine	0	pyridines; pyrrolidines		0	0		low	0	0	0	0	0	0
4-oxo-4-(3-pyridyl)butanoic acid	0	aromatic ketone; monocarboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
pyridine	0	azaarene; mancude organic heteromonocyclic parent; monocyclic heteroarene; pyridines	environmental contaminant; NMR chemical shift reference compound	0	0		low	0	0	0	0	0	0
carbinoxamine	0	monochlorobenzenes; pyridines; tertiary amino compound	anti-allergic agent; antiparkinson drug; H1-receptor antagonist; muscarinic antagonist	0	0		low	0	0	0	0	0	0
chlorpheniramine	2	monochlorobenzenes; pyridines; tertiary amino compound	anti-allergic agent; antidepressant; antipruritic drug; H1-receptor antagonist; histamine antagonist; serotonin uptake inhibitor	2003	2005	20.0	low	0	0	0	2	0	0
disopyramide	0	monocarboxylic acid amide; pyridines; tertiary amino compound	anti-arrhythmia drug	0	0		low	0	0	0	0	0	0
doxylamine	0	pyridines; tertiary amine	anti-allergic agent; antiemetic; antitussive; cholinergic antagonist; H1-receptor antagonist; histamine antagonist; sedative	0	0		low	0	0	0	0	0	0
fusaric acid	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
iproniazid	1	carbohydrazide; pyridines		1991	1991	33.0	low	0	0	1	0	0	0
lansoprazole	10	benzimidazoles; pyridines; sulfoxide	anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor	1997	2021	15.9	low	1	0	1	6	2	1
entinostat	0	benzamides; carbamate ester; primary amino compound; pyridines; substituted aniline	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
niflumic acid	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
omeprazole	31	aromatic ether; benzimidazoles; pyridines; sulfoxide		1994	2021	16.6	low	1	0	5	15	10	1
pantoprazole	2	aromatic ether; benzimidazoles; organofluorine compound; pyridines; sulfoxide	anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor; environmental contaminant; xenobiotic	2005	2006	18.5	low	0	0	0	2	0	0
pheniramine	0	pyridines; tertiary amino compound		0	0		low	0	0	0	0	0	0
pinacidil	2	pyridines		1993	2004	25.5	low	0	0	1	1	0	0
pioglitazone	12	aromatic ether; pyridines; thiazolidinediones	antidepressant; cardioprotective agent; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; geroprotector; hypoglycemic agent; insulin-sensitizing drug; PPARgamma agonist; xenobiotic	2002	2018	13.6	low	0	0	0	6	6	0
pirbuterol	0	pyridines		0	0		low	0	0	0	0	0	0
pyridinolcarbamate	0	pyridines		0	0		low	0	0	0	0	0	0
quipazine	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
rabeprazole	1	benzimidazoles; pyridines; sulfoxide	anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor	2002	2002	22.0	low	1	0	0	1	0	0
sb 202190	0	imidazoles; organofluorine compound; phenols; pyridines	apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	0	0		low	0	0	0	0	0	0
risedronic acid	0	pyridines		0	0		low	0	0	0	0	0	0
imatinib	0	aromatic amine; benzamides; N-methylpiperazine; pyridines; pyrimidines	antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor	0	0		low	0	0	0	0	0	0
streptonigrin	0	pyridines; quinolone	antimicrobial agent; antineoplastic agent	0	0		low	0	0	0	0	0	0
sulfapyridine	4	pyridines; substituted aniline; sulfonamide antibiotic; sulfonamide	antiinfective agent; dermatologic drug; drug allergen; environmental contaminant; xenobiotic	1979	2008	34.2	low	0	3	0	1	0	0
tazarotene	0	acetylenic compound; ethyl ester; pyridines; retinoid; thiochromane	keratolytic drug; prodrug; teratogenic agent	0	0		low	0	0	0	0	0	0
n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine	0	N-substituted diamine; pyridines; tertiary amino compound	apoptosis inducer; chelator; copper chelator	0	0		low	0	0	0	0	0	0
thurfyl nicotinate	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
brompheniramine	0	organobromine compound; pyridines	anti-allergic agent; H1-receptor antagonist	0	0		low	0	0	0	0	0	0
methyl nicotinate	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
citrazinic acid	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
nicotinyl alcohol	0	aromatic primary alcohol; pyridines	antilipemic drug; vasodilator agent	0	0		low	0	0	0	0	0	0
beta-nicotyrine	0	pyridines		0	0		low	0	0	0	0	0	0
3-ethylpyridine	0	pyridines		0	0		low	0	0	0	0	0	0
2-Pyridinylmethanol	0	pyridines		0	0		low	0	0	0	0	0	0
nicoboxil	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
clopyralid	0	organochlorine pesticide; pyridines	herbicide	0	0		low	0	0	0	0	0	0
oxiniacic acid	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
2-(aminomethyl)pyridine	0	pyridines		0	0		low	0	0	0	0	0	0
propiram	0	pyridines		0	0		low	0	0	0	0	0	0
n'-nitrosonornicotine	0	pyridines; pyrrolidines		0	0		low	0	0	0	0	0	0
[4-(2-pyridinyl)-1-piperazinyl]-(3,4,5-trimethoxyphenyl)methanone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
5-hydroxynicotinic acid	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
n-cyano-n'-(1,1-dimethylpropyl)-n''-(3-pyridinyl)guanidine	0	pyridines		0	0		low	0	0	0	0	0	0
4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone	0	nitrosamine; pyridines		0	0		low	0	0	0	0	0	0
haloxyfop	0	aromatic ether; monocarboxylic acid; organochlorine compound; organofluorine compound; pyridines		0	0		low	0	0	0	0	0	0
fluazifop-butyl	0	aromatic ether; carboxylic ester; organofluorine compound; pyridines		0	0		low	0	0	0	0	0	0
imazapyr, (+-)-isomer	0	imidazolines; imidazolone; pyridinemonocarboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
imazethapyr	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
2,2'-dipyridyl disulfide	0	organic disulfide; pyridines	oxidising agent	0	0		low	0	0	0	0	0	0
droxicam	0	organic heterotricyclic compound; pyridines	cyclooxygenase 1 inhibitor; hepatotoxic agent; non-narcotic analgesic; non-steroidal anti-inflammatory drug; platelet aggregation inhibitor; prodrug	0	0		low	0	0	0	0	0	0
methyridine	0	pyridines		0	0		low	0	0	0	0	0	0
picosulfate sodium	0	aryl sulfate; pyridines		0	0		low	0	0	0	0	0	0
2-hydroxynicotinic acid	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
ethylnicotinate	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
nicametate	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
nicotinamide n-oxide	0	pyridines		0	0		low	0	0	0	0	0	0
nicosulfuron	2	N-sulfonylurea; pyridines; pyrimidines	environmental contaminant; herbicide; xenobiotic	2016	2019	6.5	low	0	0	0	0	2	0
4,4'-dipyridyl disulfide	0	organic disulfide; pyridines		0	0		low	0	0	0	0	0	0
2-Chloronicotinic acid	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
4-methoxymethylpyridoxine	0	pyridines		0	0		low	0	0	0	0	0	0
6-chloronicotinic acid	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
2-pyridylacetic acid	0	pyridines		0	0		low	0	0	0	0	0	0
fluazifop	0	aromatic ether; monocarboxylic acid; organofluorine compound; pyridines		0	0		low	0	0	0	0	0	0
pyriproxyfen	0	aromatic ether; pyridines	juvenile hormone mimic	0	0		low	0	0	0	0	0	0
dithiopyr	0	organofluorine compound; pyridines; thioester		0	0		low	0	0	0	0	0	0
thiazopyr	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
dpx e9636	0	aromatic ether; N-sulfonylurea; pyridines; pyrimidines; sulfone	environmental contaminant; herbicide; xenobiotic	0	0		low	0	0	0	0	0	0
clodinafop-propargyl	0	aromatic ether; carboxylic ester; organochlorine compound; organofluorine compound; propyzamide; pyridines	agrochemical; EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor; herbicide	0	0		low	0	0	0	0	0	0
flazasulfuron	0	pyridines; sulfonamide		0	0		low	0	0	0	0	0	0
2,6-dichloroisonicotinic acid	0	monocarboxylic acid; organochlorine compound; pyridines	EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor	0	0		low	0	0	0	0	0	0
difenpiramide	0	biphenyls; monocarboxylic acid amide; pyridines	antipyretic; non-narcotic analgesic; non-steroidal anti-inflammatory drug	0	0		low	0	0	0	0	0	0
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol	0	nitrosamine; pyridines; secondary alcohol	biomarker; carcinogenic agent; human urinary metabolite	0	0		low	0	0	0	0	0	0
hydroxycotinine	0	N-alkylpyrrolidine; pyridines; pyrrolidin-2-ones; pyrrolidine alkaloid		0	0		low	0	0	0	0	0	0
5-hydroxymethylomeprazole	0	aromatic ether; benzimidazoles; pyridines; sulfoxide	drug metabolite	0	0		low	0	0	0	0	0	0
forasartan	0	benzenes; pyridines; tetrazoles; triazoles	angiotensin receptor antagonist; antihypertensive agent	0	0		low	0	0	0	0	0	0
abiraterone	0	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; pyridines	antineoplastic agent; EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor	0	0		low	0	0	0	0	0	0
agn 190299	0	monocarboxylic acid; pyridines; retinoid; thiochromane	keratolytic drug; teratogenic agent	0	0		low	0	0	0	0	0	0
vatalanib	0	monochlorobenzenes; phthalazines; pyridines; secondary amino compound	angiogenesis inhibitor; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; vascular endothelial growth factor receptor antagonist	0	0		low	0	0	0	0	0	0
metyrapol	0	pyridines		0	0		low	0	0	0	0	0	0
sb 203580	0	imidazoles; monofluorobenzenes; pyridines; sulfoxide	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector; Hsp90 inhibitor; neuroprotective agent	0	0		low	0	0	0	0	0	0
aminopyralid	0	aromatic amine; organochlorine pesticide; pyridines	herbicide	0	0		low	0	0	0	0	0	0
dabigatran etexilate	0	aromatic amide; benzimidazoles; beta-alanine derivative; carboxamidine; carboxylic ester; pyridines	anticoagulant; EC 3.4.21.5 (thrombin) inhibitor; prodrug	0	0		low	0	0	0	0	0	0
dabigatran	0	aromatic amide; benzimidazoles; beta-alanine derivative; carboxamidine; pyridines	anticoagulant; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; EC 3.4.21.5 (thrombin) inhibitor	0	0		low	0	0	0	0	0	0
alpha-(trichloromethyl)-4-pyridineethanol	0	pyridines		0	0		low	0	0	0	0	0	0
6-methyl-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile	0	nitrile; pyridines		0	0		low	0	0	0	0	0	0
gant58	0	pyridines		0	0		low	0	0	0	0	0	0
3-(3-pyridinyl)propanoic acid	0	pyridines		0	0		low	0	0	0	0	0	0
rosoxacin	0	pyridines; quinolinemonocarboxylic acid; quinolone antibiotic	antibacterial drug; antiinfective agent	0	0		low	0	0	0	0	0	0
gant 61	0	aminal; dialkylarylamine; pyridines; substituted aniline; tertiary amino compound	antineoplastic agent; apoptosis inducer; glioma-associated oncogene inhibitor; Hedgehog signaling pathway inhibitor	0	0		low	0	0	0	0	0	0
e 3040	0	benzothiazoles; organic hydroxy compound; pyridines; secondary amino compound	anti-inflammatory drug; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; uricosuric drug	0	0		low	0	0	0	0	0	0
E3040 glucuronide	0	benzothiazoles; beta-D-glucosiduronic acid; pyridines; secondary amino compound	xenobiotic metabolite	0	0		low	0	0	0	0	0	0
cerivastatin	0	dihydroxy monocarboxylic acid; pyridines; statin (synthetic)		0	0		low	0	0	0	0	0	0
hts 466284	0	pyrazoles; pyridines; quinolines	TGFbeta receptor antagonist	0	0		low	0	0	0	0	0	0
prinomastat	0	aromatic ether; hydroxamic acid; pyridines; sulfonamide; thiomorpholines	antineoplastic agent; EC 3.4.24.35 (gelatinase B) inhibitor; matrix metalloproteinase inhibitor	0	0		low	0	0	0	0	0	0
6-methyl-2-oxo-5-[oxo-(1-phenylethylamino)methyl]-1H-pyridine-3-carboxylic acid ethyl ester	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
5-(2-furanyl)-3-(3-pyridinyl)-1,2,4-oxadiazole	0	pyridines		0	0		low	0	0	0	0	0	0
1-(2-pyridin-4-yl-1-oxa-3,4-diazaspiro[4.6]undec-2-en-4-yl)ethanone	0	pyridines		0	0		low	0	0	0	0	0	0
s 1033	0	(trifluoromethyl)benzenes; imidazoles; pyridines; pyrimidines; secondary amino compound; secondary carboxamide	anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor	0	0		low	0	0	0	0	0	0
2-pyridinecarboxylic acid [2-(2,3-dichloroanilino)-2-oxoethyl] ester	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
N-methyl-N-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)-3-oxolanecarboxamide	0	pyridines		0	0		low	0	0	0	0	0	0
5-(4-propylcyclohexyl)-3-(3-pyridinyl)-1,2,4-oxadiazole	0	pyridines		0	0		low	0	0	0	0	0	0
N-methyl-N-[5-(2-pyridinyl)-1,3,4-thiadiazol-2-yl]-3-oxolanecarboxamide	0	pyridines		0	0		low	0	0	0	0	0	0
2-methoxy-N-methyl-N-[5-(2-pyridinyl)-1,3,4-thiadiazol-2-yl]acetamide	0	pyridines		0	0		low	0	0	0	0	0	0
6-methyl-2-[4-[oxo(thiophen-2-yl)methyl]-1-piperazinyl]-3-quinolinecarbonitrile	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
[5-(2-furanyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
6-hydroxy-1-(3-hydroxypropyl)-4-methyl-2-oxo-5-(1-piperidinylmethyl)-3-pyridinecarbonitrile	0	nitrile; pyridines		0	0		low	0	0	0	0	0	0
5,8-dimethoxy-4-(4-methyl-1-piperazinyl)-2-(trifluoromethyl)quinoline	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
5-ethyl-4,6-dimethyl-2-sulfanylidene-1H-pyridine-3-carbonitrile	0	nitrile; pyridines		0	0		low	0	0	0	0	0	0
8-(2-furanyl)-6-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-3,3-dimethyl-1,4-dihydrothiopyrano[3,4-c]pyridine-5-carbonitrile	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
N-(4-{[2-(pyridin-3-yl)piperidin-1-yl]sulfonyl}phenyl)acetamide	0	acetamides; piperidines; pyridines; sulfonamide		0	0		low	0	0	0	0	0	0
2-(pyridin-4-yl)-4-(pyrrolidin-1-yl)quinazoline	0	pyridines; pyrrolidines; quinazolines		0	0		low	0	0	0	0	0	0
2-methyl-3-phenyl-5-propyl-7-[4-(2-pyridinyl)-1-piperazinyl]pyrazolo[1,5-a]pyrimidine	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
prothionamide	0	pyridines		0	0		low	0	0	0	0	0	0
N2-(4-fluorophenyl)-6-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1,3,5-triazine-2,4-diamine	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
1-(4-methyl-1,2,5-oxadiazol-3-yl)-3-(3-pyridinyl)urea	0	pyridines		0	0		low	0	0	0	0	0	0
N-(3-fluorophenyl)-2-(pyridin-4-yl)quinazolin-4-amine	0	aromatic amine; monofluorobenzenes; pyridines; quinazolines; secondary amino compound; substituted aniline		0	0		low	0	0	0	0	0	0
5-cyano-2-methyl-6-sulfanylidene-1H-pyridine-3-carboxylic acid ethyl ester	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
2-(1H-imidazol-1-yl)-5-(trifluoromethyl)pyridine	0	pyridines		0	0		low	0	0	0	0	0	0
5-(3-pyridinylmethyl)-1,3,5-triazinane-2-thione	0	pyridines		0	0		low	0	0	0	0	0	0
2-amino-5-ethyl-4-(2-furanyl)-6-propyl-3-pyridinecarbonitrile	0	nitrile; pyridines		0	0		low	0	0	0	0	0	0
4-(methoxymethyl)-6-methyl-2-(2-methylanilino)-3-pyridinecarbonitrile	0	nitrile; pyridines		0	0		low	0	0	0	0	0	0
GS4012 free base	0	aryl sulfide; monomethoxybenzene; pyridines	VEGF activator	0	0		low	0	0	0	0	0	0
5-(phenylmethyl)-3-(2-pyridinyl)-1,2,4-oxadiazole	0	pyridines		0	0		low	0	0	0	0	0	0
4-(methoxymethyl)-6-methyl-2-(4-phenyl-1-piperazinyl)-3-pyridinecarbonitrile	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
1-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-2-benzo[cd]indolone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
cotinine	4	N-alkylpyrrolidine; pyridines; pyrrolidin-2-ones; pyrrolidine alkaloid	antidepressant; biomarker; human xenobiotic metabolite; plant metabolite	2009	2014	11.8	low	1	0	0	1	3	0
1-propylsulfonyl-4-(2-pyridinyl)piperazine	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
2-(2-phenylethylthio)-3-pyridinecarboxylic acid	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
1,3-benzothiazol-2-yl-[4-(2-pyridinyl)-1-piperazinyl]methanone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
2-(2,6-dichloroanilino)-3-pyridinesulfonamide	0	pyridines; sulfonamide		0	0		low	0	0	0	0	0	0
4-(4-chloroanilino)-3-pyridinesulfonamide	0	pyridines; sulfonamide		0	0		low	0	0	0	0	0	0
6-(2-oxopropylthio)-3-pyridinecarboxylic acid	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
6-chloro-N-(2-hydroxyphenyl)-3-pyridinesulfonamide	0	pyridines; sulfonamide		0	0		low	0	0	0	0	0	0
3-(phenylmethyl)-6-pyridin-4-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	0	pyridines; triazolothiadiazole		0	0		low	0	0	0	0	0	0
6-(4-benzoyl-1-piperazinyl)-3,3-dimethyl-8-propan-2-yl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
5-bromo-6-chloro-N-(4-methyl-2-pyridinyl)-3-pyridinesulfonamide	0	pyridines; sulfonamide		0	0		low	0	0	0	0	0	0
pyrabactin	0	naphthalenes; organobromine compound; pyridines; sulfonamide	abscisic acid receptor agonist; hormone; plant growth regulator	0	0		low	0	0	0	0	0	0
4-[4-(benzenesulfonyl)-1-piperazinyl]-2-methylquinoline	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
2-(4-bromophenyl)-1-[4-(2-pyridinyl)-1-piperazinyl]ethanone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
(4-chlorophenyl)-[4-(7-chloro-4-quinolinyl)-1-piperazinyl]methanone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
7-chloro-4-[4-(3,4-dimethylphenyl)sulfonyl-1-piperazinyl]quinoline	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
1-ethyl-3-sulfanylidene-5,6,7,8-tetrahydro-2H-isoquinoline-4-carbonitrile	0	pyridines		0	0		low	0	0	0	0	0	0
7-methoxy-2-[4-[(2-methylphenyl)-oxomethyl]-1-piperazinyl]-3-quinolinecarbonitrile	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
6-tert-butyl-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile	0	nitrile; pyridines		0	0		low	0	0	0	0	0	0
5-cyano-2-phenyl-6-[4-(2-pyridinyl)-1-piperazinyl]-3-pyridinecarboxylic acid ethyl ester	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
N,N-dibutyl-2-(pyridin-4-yl)quinazolin-4-amine	0	pyridines; quinazolines; tertiary amino compound		0	0		low	0	0	0	0	0	0
4,6-dimethyl-2-[3-(4-morpholinyl)propylamino]-3-pyridinecarbonitrile	0	nitrile; pyridines		0	0		low	0	0	0	0	0	0
2-ethoxy-3-pyridinecarboxylic acid [2-[1-(2-furanylmethyl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl] ester	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
mcb-613	0	cyclic ketone; enone; pyridines	antineoplastic agent; steroid receptor coactivator stimulator	0	0		low	0	0	0	0	0	0
5,6-dichloro-3-pyridinecarboxylic acid [2-(2-furanylmethylamino)-2-oxoethyl] ester	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
4-pyridinecarboxylic acid [2-[1-(2-furanylmethyl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl] ester	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
2-oxo-1H-pyridine-3-carboxylic acid [2-(2,5-dimethyl-1-propyl-3-pyrrolyl)-2-oxoethyl] ester	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
2-thiopyridine	0	aryl thiol; pyridines	allergen; fluorescence quencher	0	0		low	0	0	0	0	0	0
2-(methylamino)-6-thiophen-2-yl-4-(trifluoromethyl)-3-pyridinecarbonitrile	0	nitrile; pyridines		0	0		low	0	0	0	0	0	0
2-(1-piperidinyl)-6-thiophen-2-yl-4-(trifluoromethyl)-3-pyridinecarbonitrile	0	nitrile; pyridines		0	0		low	0	0	0	0	0	0
N-benzyl-N'-methyl-N-(pyridin-3-ylmethyl)thiourea	0	pyridines		0	0		low	0	0	0	0	0	0
3-Chloro-5-(trifluoromethyl)pyridine-2-carbothioamide	0	pyridines		0	0		low	0	0	0	0	0	0
2,6-dimethyl-4-(3-thienyl)pyridine-3,5-dicarboxylic acid	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
N-tert-butyl-4-[3-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
5-cyano-2-(methoxymethyl)-6-sulfanylidene-1H-pyridine-3-carboxylic acid methyl ester	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
ethionamide	0	pyridines; thiocarboxamide	antilipemic drug; antitubercular agent; fatty acid synthesis inhibitor; leprostatic drug; prodrug	0	0		low	0	0	0	0	0	0
2-amino-6-[4-(6-chloro-2-pyridinyl)-1-piperazinyl]pyridine-3,5-dicarbonitrile	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
2-(propylthio)nicotinic acid	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
5-Chloro-2-hydroxy-4,6-dimethylnicotinonitrile	0	nitrile; pyridines		0	0		low	0	0	0	0	0	0
3-[1-(2,4-dichlorophenyl)sulfonyl-2-pyrrolidinyl]pyridine	0	pyridines; pyrrolidines		0	0		low	0	0	0	0	0	0
(3,5-dichlorophenyl)-[4-[2-(trifluoromethyl)-4-quinolinyl]-1-piperazinyl]methanone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
3-[5-[[4-(2-pyridinyl)-1-piperazinyl]sulfonyl]-2-thiophenyl]isoxazole	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
2-oxo-4,6-dithiophen-2-yl-1H-pyridine-3-carbonitrile	0	nitrile; pyridines		0	0		low	0	0	0	0	0	0
4-[4-(3-bromophenyl)sulfonyl-1-piperazinyl]-7-chloroquinoline	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
3,7-dimethyl-2-[4-(2-pyridinyl)-1-piperazinyl]quinoline	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
3-phenyl-1-[4-(2-pyridinyl)-1-piperazinyl]-1-propanone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
4-phenoxy-1-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
2-[4-(2-methyl-4-quinolinyl)-1-piperazinyl]-4-phenylthiazole	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
6-(2,3-dihydro-1,4-benzodioxin-3-ylmethylamino)-N-ethyl-N-phenyl-3-pyridinesulfonamide	0	pyridines; sulfonamide		0	0		low	0	0	0	0	0	0
alpha-nicotyrine	0	pyridines		0	0		low	0	0	0	0	0	0
dapiprazole	0	N-alkylpiperazine; N-arylpiperazine; pyridines	alpha-adrenergic antagonist; antipsychotic agent; miotic; ophthalmology drug	0	0		low	0	0	0	0	0	0
glucitol hexanicotinate	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline	0	organic heterotricyclic compound; organofluorine compound; pyridines; secondary amino compound		0	0		low	0	0	0	0	0	0
N-(1,3-benzodioxol-5-ylmethyl)-N-[2-(cyclohexylamino)-2-oxo-1-pyridin-4-ylethyl]-2,2,2-trifluoroacetamide	0	benzodioxoles; pyridines; secondary carboxamide; tertiary carboxamide; trifluoroacetamide		0	0		low	0	0	0	0	0	0
1-methyl-4-[[2-oxo-2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]thio]-2-quinolinone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
1-(4-amino-1,2,5-oxadiazol-3-yl)-5-[(2-pyridinylthio)methyl]-4-triazolecarboxylic acid propan-2-yl ester	0	aryl sulfide; azole; isopropyl ester; oxadiazole; pyridines		0	0		low	0	0	0	0	0	0
6-bromo-3-[4-oxo-4-[4-(2-pyridinyl)-1-piperazinyl]butyl]-2-sulfanylidene-1H-quinazolin-4-one	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
N-[4-methyl-2-(4-methyl-1-piperazinyl)-6-quinolinyl]-1,3-benzodioxole-5-carboxamide	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
4-[2-(1-cyclohexenyl)ethyl]-1-cyclohexyl-3-pyridin-4-ylpiperazine-2,5-dione	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
ml012	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
[4-(2-pyrimidinyl)-1-piperazinyl]-[1-[4-(2-pyrimidinyl)-1-piperazinyl]-4-isoquinolinyl]methanone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
N-(2-furanylmethyl)-N'-[4-methyl-2-(4-methyl-1-piperazinyl)-6-quinolinyl]butanediamide	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
[3-(4-methylphenyl)-1-phenyl-4-pyrazolyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
2-pyridinecarboxylic acid [2-(5-chloro-2-thiophenyl)-2-oxoethyl] ester	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
2-[[2-[(2-methoxyphenyl)methylamino]-2-oxoethyl]thio]-3-pyridinecarboxylic acid [2-[(2-methoxyphenyl)methylamino]-2-oxoethyl] ester	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
2-[(5-formyl-2-methoxyphenyl)methylthio]-3-pyridinecarboxylic acid	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
[3-(2,3-dihydroindol-1-ylsulfonyl)phenyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
3-(4-benzoyl-1-piperazinyl)-1-(2-methylpropyl)-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
5-cyano-6-[4-(4-methoxyphenyl)-1-piperazinyl]-2-oxo-1H-pyridine-3-carboxylic acid ethyl ester	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
2-[4-(3-chlorophenyl)-1-piperazinyl]-3-pyridinecarboxylic acid propan-2-yl ester	0	isopropyl ester; piperazines; pyridines		0	0		low	0	0	0	0	0	0
3-(1-hydroxy-5,5-dimethyl-4-phenyl-2H-imidazol-2-yl)pyridine	0	pyridines		0	0		low	0	0	0	0	0	0
[4-[(2-chlorophenyl)methylsulfonyl]-3-nitrophenyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
2-pyridinecarboxylic acid [2-[2-(difluoromethoxy)anilino]-2-oxoethyl] ester	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
hydroxypioglitazone	0	aromatic ether; pyridines; thiazolidinediones	human xenobiotic metabolite	0	0		low	0	0	0	0	0	0
2-(2-fluoroanilino)-3-pyridinecarboxylic acid [2-[(1,1-dioxo-3-thiolanyl)-methylamino]-2-oxoethyl] ester	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
3-(4-ethylphenyl)-4-hydroxy-4-[oxo-[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-quinazolin-2-one	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide	0	benzamides; benzodioxoles; imidazoles; pyridines	EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	0	0		low	0	0	0	0	0	0
N-(1-benzylpiperidin-4-yl)-2-(pyridin-3-yl)quinazolin-4-amine	0	aromatic amine; piperidines; pyridines; quinazolines; secondary amino compound; tertiary amino compound		0	0		low	0	0	0	0	0	0
abt724	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
2-(4-acetyl-1-piperazinyl)-6-amino-4-(cyanomethyl)pyridine-3,5-dicarbonitrile	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
triprolidine	0	N-alkylpyrrolidine; olefinic compound; pyridines	H1-receptor antagonist	0	0		low	0	0	0	0	0	0
pibutidine	0	aromatic ether; cyclobutenones; olefinic compound; piperidines; primary amino compound; pyridines; secondary amino compound	anti-ulcer drug; H2-receptor antagonist	0	0		low	0	0	0	0	0	0
acrivastine	0	alpha,beta-unsaturated monocarboxylic acid; N-alkylpyrrolidine; olefinic compound; pyridines	H1-receptor antagonist	0	0		low	0	0	0	0	0	0
2-[3-(diethylamino)propylamino]-4-(methoxymethyl)-6-methyl-3-pyridinecarbonitrile	0	nitrile; pyridines		0	0		low	0	0	0	0	0	0
[2-(1-piperidinyl)-1,3-benzothiazol-6-yl]-[4-(2-pyridinyl)-1-piperazinyl]methanone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
N-[2-(4-ethyl-1-piperazinyl)-4-methyl-6-quinolinyl]-2-pyrazinecarboxamide	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
clodinafop	0	aromatic ether; monocarboxylic acid; organochlorine compound; organofluorine compound; pyridines	EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor; phenoxy herbicide	0	0		low	0	0	0	0	0	0
3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	0	enone; pyridines	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; autophagy inducer; EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor	0	0		low	0	0	0	0	0	0
[4-(3-chlorophenyl)sulfonyl-3-nitrophenyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
axitinib	0	aryl sulfide; benzamides; indazoles; pyridines	antineoplastic agent; tyrosine kinase inhibitor; vascular endothelial growth factor receptor antagonist	0	0		low	0	0	0	0	0	0
2-[4-(2-pyrimidinyl)-1-piperazinyl]quinoline	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
(2-Chloro-4-pyridinyl)methanol	0	organohalogen compound; pyridines		0	0		low	0	0	0	0	0	0
pymetrozine	0	1,2,4-triazines; pyridines	antifeedant; environmental contaminant; TRPV channel modulator; xenobiotic	0	0		low	0	0	0	0	0	0
abiraterone acetate	0	pyridines; sterol ester	antineoplastic agent; EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor; prodrug	0	0		low	0	0	0	0	0	0
n-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2h)-carboxamide	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
4-(1H-imidazol-5-ylmethyl)pyridine	0	pyridines		0	0		low	0	0	0	0	0	0
680c91	0	fluoroindole; olefinic compound; pyridines	EC 1.13.11.11 (tryptophan 2,3-dioxygenase) inhibitor	0	0		low	0	0	0	0	0	0
masitinib	0	1,3-thiazoles; benzamides; N-alkylpiperazine; pyridines	antineoplastic agent; antirheumatic drug; tyrosine kinase inhibitor	0	0		low	0	0	0	0	0	0
vorapaxar	0	carbamate ester; lactone; naphthofuran; organofluorine compound; pyridines	cardiovascular drug; platelet aggregation inhibitor; protease-activated receptor-1 antagonist	0	0		low	0	0	0	0	0	0
azd2858	0	aromatic amine; N-methylpiperazine; pyrazines; pyridines; secondary carboxamide; sulfonamide	antineoplastic agent; bone density conservation agent; EC 2.7.11.26 (tau-protein kinase) inhibitor; Wnt signalling activator	0	0		low	0	0	0	0	0	0
ciclonicate	0	aromatic carboxylic acid; pyridines		0	0		low	0	0	0	0	0	0
tedizolid	0	carbamate ester; organofluorine compound; oxazolidinone; primary alcohol; pyridines; tetrazoles	antimicrobial agent; drug metabolite; protein synthesis inhibitor	0	0		low	0	0	0	0	0	0
chlorantranilipole	0	monochlorobenzenes; organobromine compound; pyrazole insecticide; pyrazoles; pyridines; secondary carboxamide	ryanodine receptor agonist	0	0		low	0	0	0	0	0	0
picoxystrobin	0	aromatic ether; enoate ester; enol ether; methoxyacrylate strobilurin antifungal agent; organofluorine compound; pyridines	antifungal agrochemical; mitochondrial cytochrome-bc1 complex inhibitor	0	0		low	0	0	0	0	0	0
tedizolid phosphate	0	carbamate ester; organofluorine compound; oxazolidinone; phosphate monoester; pyridines; tetrazoles	antimicrobial agent; prodrug; protein synthesis inhibitor	0	0		low	0	0	0	0	0	0
dorsomorphin	0	aromatic ether; piperidines; pyrazolopyrimidine; pyridines	bone morphogenetic protein receptor antagonist; EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor	0	0		low	0	0	0	0	0	0
cyantraniliprole	0	nitrile; organobromine compound; organochlorine compound; pyrazole insecticide; pyridines; secondary carboxamide	ryanodine receptor agonist	0	0		low	0	0	0	0	0	0
GDC-0879	0	indanes; ketoxime; primary alcohol; pyrazoles; pyridines	antineoplastic agent; B-Raf inhibitor	0	0		low	0	0	0	0	0	0
bgt226	0	aromatic ether; imidazoquinoline; N-arylpiperazine; organofluorine compound; pyridines	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor	0	0		low	0	0	0	0	0	0
[4-(3-chlorophenyl)-1-piperazinyl]-[1-[4-(2-pyridinyl)-1-piperazinyl]-4-isoquinolinyl]methanone	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
dafadine C	0	aromatic amide; aromatic ether; difluorobenzene; isoxazoles; N-acylpiperidine; pyridines	P450 inhibitor	0	0		low	0	0	0	0	0	0
dafadine B	0	aromatic amide; aromatic ether; isoxazoles; monochlorobenzenes; monofluorobenzenes; N-acylpiperidine; pyridines	P450 inhibitor	0	0		low	0	0	0	0	0	0
1-butyl-3-[2-(4-ethyl-1-piperazinyl)-4-methyl-6-quinolinyl]-1-methylthiourea	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
lumacaftor	0	aromatic amide; benzodioxoles; benzoic acids; cyclopropanes; organofluorine compound; pyridines	CFTR potentiator; orphan drug	0	0		low	0	0	0	0	0	0
ro5126766	0	aryloxypyrimidine; coumarins; organofluorine compound; pyridines; sulfamides	antineoplastic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	0	0		low	0	0	0	0	0	0
sulfoxaflor	0	nitrile; organofluorine compound; pyridines; sulfoximide		0	0		low	0	0	0	0	0	0
cnf 2024	0	2-aminopurines; aromatic ether; organochlorine compound; pyridines	antineoplastic agent; Hsp90 inhibitor	0	0		low	0	0	0	0	0	0
gdc 0449	0	benzamides; monochlorobenzenes; pyridines; sulfone	antineoplastic agent; Hedgehog signaling pathway inhibitor; SMO receptor antagonist; teratogenic agent	0	0		low	0	0	0	0	0	0
bms 754807	0	pyrazoles; pyridines; pyrrolidines; pyrrolotriazine	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	0	0		low	0	0	0	0	0	0
4-(1-((5-((2,6-dimethylphenoxy)methyl)-3-isoxazolyl)carbonyl)-4-piperidinyl)pyridine	0	aromatic amide; aromatic ether; isoxazoles; N-acylpiperidine; pyridines	geroprotector; P450 inhibitor	0	0		low	0	0	0	0	0	0
dafadine D	0	aromatic amide; aromatic ether; isoxazoles; N-acylpiperidine; organofluorine compound; pyridines	P450 inhibitor	0	0		low	0	0	0	0	0	0
dafadine O	0	aromatic amide; aromatic ether; isoxazoles; N-acylpiperidine; pyridines; ring assembly	P450 inhibitor	0	0		low	0	0	0	0	0	0
florbetapir f 18	0	(18)F radiopharmaceutical; aromatic ether; organofluorine compound; pyridines; substituted aniline	radioactive imaging agent	0	0		low	0	0	0	0	0	0
sch772984	0	biaryl; indazoles; N-acylpiperazine; N-alkylpyrrolidine; N-arylpiperazine; pyridines; pyrimidines; pyrrolidinecarboxamide; secondary carboxamide; tertiary amino compound; tertiary carboxamide	analgesic; antineoplastic agent; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	0	0		low	0	0	0	0	0	0
gsk 2126458	0	aromatic ether; difluorobenzene; pyridazines; pyridines; quinolines; sulfonamide	anticoronaviral agent; antineoplastic agent; autophagy inducer; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor; radiosensitizing agent	0	0		low	0	0	0	0	0	0
1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(2-pyridinylsulfonyl)piperazine	0	pyridines; sulfonamide		0	0		low	0	0	0	0	0	0
ml228 probe	0	1,2,4-triazines; biphenyls; pyridines; secondary amino compound	hypoxia-inducible factor pathway activator	0	0		low	0	0	0	0	0	0
lgk974	0	bipyridines; pyrazines; pyridines; secondary carboxamide	Wnt signalling inhibitor	0	0		low	0	0	0	0	0	0
N-(4,6-dimethyl-2-pyridinyl)-4-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarbothioamide	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
afidopyropen	0	cyclopropanecarboxylate ester; organic heterotetracyclic compound; pyridines; secondary alcohol	agrochemical; insecticide; TRPV channel modulator	0	0		low	0	0	0	0	0	0
piroxicam	13	benzothiazine; monocarboxylic acid amide; pyridines	analgesic; antirheumatic drug; cyclooxygenase 1 inhibitor; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-steroidal anti-inflammatory drug	1985	2023	22.3	low	0	1	5	5	1	1
mobiflex	0	heteroaryl hydroxy compound; monocarboxylic acid amide; pyridines; thienothiazine	antipyretic; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug	0	0		low	0	0	0	0	0	0
lornoxicam	0	heteroaryl hydroxy compound; monocarboxylic acid amide; organochlorine compound; pyridines; thienothiazine	antipyretic; non-narcotic analgesic; non-steroidal anti-inflammatory drug	0	0		low	0	0	0	0	0	0
MK-8353	0	aromatic ether; dihydropyridine; indazoles; methyl sulfide; N-alkylpyrrolidine; pyridines; pyrrolidinecarboxamide; secondary carboxamide; tertiary carboxamide; triazoles	antineoplastic agent; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	0	0		low	0	0	0	0	0	0
gsk-2816126	0	piperazines; pyridines		0	0		low	0	0	0	0	0	0
acp-196	0	aromatic amine; benzamides; imidazopyrazine; pyridines; pyrrolidinecarboxamide; secondary carboxamide; tertiary carboxamide; ynone	antineoplastic agent; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor	0	0		low	0	0	0	0	0	0
GSK1059615	0	pyridines; quinolines; thiazolidinone	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor	0	0		low	0	0	0	0	0	0
pf-06687252	0	azabicycloalkane; enone; phenols; pyridines		0	0		low	0	0	0	0	0	0
2-hydroxy-3-(5-((morpholin-4-yl)methyl)pyridin-2-yl)-1h-indole-5-carbonitrile	0	hydroxyindoles; morpholines; nitrile; pyridines; tertiary amino compound	antineoplastic agent; apoptosis inducer; EC 2.7.11.26 (tau-protein kinase) inhibitor; tau aggregation inhibitor	0	0		low	0	0	0	0	0	0
sb-590885	0	aromatic ether; imidazoles; ketoxime; pyridines; tertiary amino compound		0	0		low	0	0	0	0	0	0
dabigatran etexilate	0	aromatic amide; benzimidazoles; beta-alanine derivative; carboxamidine; carboxylic ester; pyridines	anticoagulant; EC 3.4.21.5 (thrombin) inhibitor; prodrug	0	0		low	0	0	0	0	0	0
3-aminobenzamide	0	benzamides; substituted aniline	EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor	0	0		low	0	0	0	0	0	0
dan 2163	0	aromatic amide; aromatic amine; benzamides; pyrrolidines; sulfone	environmental contaminant; second generation antipsychotic; xenobiotic	0	0		low	0	0	0	0	0	0
benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
bromopride	0	benzamides		0	0		low	0	0	0	0	0	0
ci 994	0	acetamides; benzamides; substituted aniline	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
cisapride	0	benzamides		0	0		low	0	0	0	0	0	0
2-hexyloxybenzamide	0	aromatic ether; benzamides	antifungal agent	0	0		low	0	0	0	0	0	0
itopride	0	benzamides		0	0		low	0	0	0	0	0	0
labetalol	0	benzamides; benzenes; phenols; primary carboxamide; salicylamides; secondary alcohol; secondary amino compound		0	0		low	0	0	0	0	0	0
lorglumide	0	benzamides; dicarboxylic acid monoamide; dichlorobenzene; glutamic acid derivative		0	0		low	0	0	0	0	0	0
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamide	0	benzamides; hydroxamic acid; secondary carboxamide; tertiary amino compound	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
metoclopramide	0	benzamides; monochlorobenzenes; substituted aniline; tertiary amino compound	antiemetic; dopaminergic antagonist; environmental contaminant; gastrointestinal drug; xenobiotic	0	0		low	0	0	0	0	0	0
moclobemide	0	benzamides; monochlorobenzenes; morpholines	antidepressant; environmental contaminant; xenobiotic	0	0		low	0	0	0	0	0	0
deet	0	benzamides; monocarboxylic acid amide	environmental contaminant; insect repellent; xenobiotic	0	0		low	0	0	0	0	0	0
acecainide	2	acetamides; benzamides	anti-arrhythmia drug	1995	2008	22.5	low	0	0	1	1	0	0
nemonapride	0	benzamides; monochlorobenzenes; monomethoxybenzene; N-alkylpyrrolidine; secondary amino compound; secondary carboxamide; substituted aniline		0	0		low	0	0	0	0	0	0
niclosamide	0	benzamides; C-nitro compound; monochlorobenzenes; salicylanilides; secondary carboxamide	anthelminthic drug; anticoronaviral agent; antiparasitic agent; apoptosis inducer; molluscicide; piscicide; STAT3 inhibitor	0	0		low	0	0	0	0	0	0
picotamide	0	benzamides		0	0		low	0	0	0	0	0	0
procainamide	4	benzamides	anti-arrhythmia drug; platelet aggregation inhibitor; sodium channel blocker	1994	2008	22.8	low	0	0	2	2	0	0
procarbazine	2	benzamides; hydrazines	antineoplastic agent	1991	1993	32.0	low	0	0	2	0	0	0
proglumetacin	0	aromatic ether; benzamides; carboxylic ester; monochlorobenzenes; N-acylindole; N-alkylpiperazine	antipyretic; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; lipoxygenase inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug; prodrug	0	0		low	0	0	0	0	0	0
proglumide	2	benzamides; dicarboxylic acid monoamide; glutamine derivative; racemate	anti-ulcer drug; cholecystokinin antagonist; cholinergic antagonist; delta-opioid receptor agonist; drug metabolite; gastrointestinal drug; opioid analgesic; xenobiotic metabolite	2005	2010	16.5	low	0	0	0	2	0	0
sulpiride	1	benzamides; N-alkylpyrrolidine; sulfonamide	antidepressant; antiemetic; antipsychotic agent; dopaminergic antagonist	2019	2019	5.0	low	0	0	0	0	1	0
tiapride	0	benzamides		0	0		low	0	0	0	0	0	0
trimethobenzamide	0	benzamides; tertiary amino compound	antiemetic	0	0		low	0	0	0	0	0	0
troxipide	0	benzamides		0	0		low	0	0	0	0	0	0
zm 336372	0	benzamides		0	0		low	0	0	0	0	0	0
iodohippuric acid	0	benzamides; N-acylglycine; organoiodine compound		0	0		low	0	0	0	0	0	0
benzoylarginine-2-naphthylamide	0	arginine derivative; benzamides; N-(2-naphthyl)carboxamide		0	0		low	0	0	0	0	0	0
4-(benzoylamino)-2-hydroxybenzoic acid	0	benzamides		0	0		low	0	0	0	0	0	0
ameltolide	0	benzamides		0	0		low	0	0	0	0	0	0
antimycin a	0	benzamides; formamides; macrodiolide; phenols	antifungal agent; mitochondrial respiratory-chain inhibitor; piscicide	0	0		low	0	0	0	0	0	0
rebemide	0	benzamides		0	0		low	0	0	0	0	0	0
2,6-dichlorobenzamide	0	benzamides; dichlorobenzene	herbicide; marine xenobiotic metabolite	0	0		low	0	0	0	0	0	0
fluorophene	0	benzamides		0	0		low	0	0	0	0	0	0
2-toluanilide	0	benzamides; benzanilide fungicide		0	0		low	0	0	0	0	0	0
2-bromo-N-phenylbenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
xipamide	0	benzamides		0	0		low	0	0	0	0	0	0
capobenic acid	0	benzamides		0	0		low	0	0	0	0	0	0
pronamide	0	benzamides; dichlorobenzene; terminal acetylenic compound	agrochemical; herbicide	0	0		low	0	0	0	0	0	0
clanobutin	0	benzamides		0	0		low	0	0	0	0	0	0
nitazoxanide	0	benzamides; carboxylic ester		0	0		low	0	0	0	0	0	0
Flamprop	0	benzamides		0	0		low	0	0	0	0	0	0
N-[4-(dimethylamino)phenyl]-3,4,5-trimethoxybenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
endralazine	0	benzamides		0	0		low	0	0	0	0	0	0
flutolanil	0	(trifluoromethyl)benzenes; aromatic ether; benzamides; benzanilide fungicide	antifungal agrochemical; EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor	0	0		low	0	0	0	0	0	0
encainide	0	benzamides; piperidines	anti-arrhythmia drug; sodium channel blocker	0	0		low	0	0	0	0	0	0
nelfinavir	0	aryl sulfide; benzamides; organic heterobicyclic compound; phenols; secondary alcohol; tertiary amino compound	antineoplastic agent; HIV protease inhibitor	0	0		low	0	0	0	0	0	0
n-benzoylpiperidine	0	benzamides; N-acylpiperidine		0	0		low	0	0	0	0	0	0
pancopride	0	benzamides		0	0		low	0	0	0	0	0	0
octylonium	0	benzamides		0	0		low	0	0	0	0	0	0
parsalmide	0	benzamides		0	0		low	0	0	0	0	0	0
isoxaben	0	benzamides; isoxazoles	cellulose synthesis inhibitor; herbicide	0	0		low	0	0	0	0	0	0
4-aminobenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
4-Methoxybenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
benzoyltyrosine ethyl ester	0	benzamides; ethyl ester; L-tyrosine derivative; phenols	chromogenic compound	0	0		low	0	0	0	0	0	0
salifungin	0	benzamides		0	0		low	0	0	0	0	0	0
n-benzoyl-l-arginine	0	benzamides; N-acyl-L-arginine		0	0		low	0	0	0	0	0	0
gr 127935	0	1,2,4-oxadiazole; benzamides; N-alkylpiperazine; N-arylpiperazine		0	0		low	0	0	0	0	0	0
zacopride	0	benzamides		0	0		low	0	0	0	0	0	0
mozavaptan	0	benzamides	aquaretic	0	0		low	0	0	0	0	0	0
mosapride	0	aromatic ether; benzamides; monochlorobenzenes; monofluorobenzenes; morpholines; secondary carboxamide; substituted aniline; tertiary amino compound		0	0		low	0	0	0	0	0	0
zoxamide	0	alpha-chloroketone; benzamides; dichlorobenzene		0	0		low	0	0	0	0	0	0
procainamide 4-hydroxylamine	0	benzamides; hydroxylamines	drug metabolite	0	0		low	0	0	0	0	0	0
ly 188544	0	benzamides		0	0		low	0	0	0	0	0	0
gr 55562	0	benzamides		0	0		low	0	0	0	0	0	0
n-(2,6-dimethylphenyl)-4-(((diethylamino)acetyl)amino)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
tariquidar	0	benzamides		0	0		low	0	0	0	0	0	0
n-benzoyltyrosine	0	benzamides; N-acyl-L-tyrosine		0	0		low	0	0	0	0	0	0
rp 73401	0	aromatic ether; benzamides; chloropyridine; monocarboxylic acid amide	anti-asthmatic drug; anti-inflammatory agent; bronchodilator agent; phosphodiesterase IV inhibitor	0	0		low	0	0	0	0	0	0
brovanexine	0	benzamides		0	0		low	0	0	0	0	0	0
aminopotentidine	0	aromatic ether; benzamides; guanidines; nitrile; piperidines; substituted aniline	H2-receptor antagonist	0	0		low	0	0	0	0	0	0
asperphenamate	0	benzamides; carboxylic ester; L-phenylalanine derivative	antineoplastic agent	0	0		low	0	0	0	0	0	0
N-(3-fluorophenyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
benzoylphenylalanine	0	benzamides; N-acyl-amino acid		0	0		low	0	0	0	0	0	0
2-methoxy-N-[2-(methylthio)phenyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
2-(4-fluorobenzoylamino)benzoic acid methyl ester	0	benzamides		0	0		low	0	0	0	0	0	0
xv 638	0	1,3-thiazoles; benzamides; diazepanone; diol; secondary alcohol; secondary carboxamide; ureas	HIV protease inhibitor	0	0		low	0	0	0	0	0	0
roflumilast	0	aromatic ether; benzamides; chloropyridine; cyclopropanes; organofluorine compound	anti-asthmatic drug; phosphodiesterase IV inhibitor	0	0		low	0	0	0	0	0	0
2-(3-benzamidophenoxy)acetic acid	0	benzamides		0	0		low	0	0	0	0	0	0
ck-0944666	0	benzamides; indoles; organofluorine compound	actin polymerisation inhibitor	0	0		low	0	0	0	0	0	0
gw9662	0	benzamides		0	0		low	0	0	0	0	0	0
N-[2-(1-cyclohexenyl)ethyl]-4-(4-morpholinylmethyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
2-methoxy-N-[6-(1-oxobutylamino)-3-pyridinyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-[4-chloro-2-[(2,4-dimethoxyanilino)-oxomethyl]phenyl]-2-furancarboxamide	0	benzamides		0	0		low	0	0	0	0	0	0
[3-[3-(5-methyl-2-furanyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-phenylmethanone	0	benzamides; N-acylpiperidine		0	0		low	0	0	0	0	0	0
4-methyl-N-[2-[4-(2-methyl-1-oxopropyl)-1-piperazinyl]phenyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-[2-(2-ethyl-5-tetrazolyl)phenyl]-3-(1-tetrazolyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-[2-(2-ethyl-5-tetrazolyl)phenyl]-4-(1-tetrazolyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-[2,5-diethoxy-4-[[oxo-(3,4,5-trimethoxyphenyl)methyl]amino]phenyl]-2-furancarboxamide	0	benzamides		0	0		low	0	0	0	0	0	0
(2,4-difluorophenyl)-[3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]methanone	0	benzamides; N-acylpiperidine		0	0		low	0	0	0	0	0	0
2-ethoxy-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
4-methyl-N-(2-methyl-5-tetrazolyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-[2,5-dimethoxy-4-[[2-(4-morpholinyl)-1-oxoethyl]amino]phenyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(4-fluorophenyl)-4-(2-oxolanylmethylsulfamoyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
azidopine	0	benzamides		0	0		low	0	0	0	0	0	0
4-methoxy-N1,N3-bis(3-pyridinyl)benzene-1,3-dicarboxamide	0	benzamides		0	0		low	0	0	0	0	0	0
2,3,4,5,6-pentafluoro-N-(phenylmethyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(1,1-dioxo-3-thiolanyl)-N-(thiophen-2-ylmethyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(3-methoxyphenyl)-2-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
2-[[(4-acetyloxy-3-methoxyphenyl)-oxomethyl]amino]-5-hydroxybenzoic acid	0	benzamides		0	0		low	0	0	0	0	0	0
N-(3-acetamidophenyl)-4-methoxybenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(3-acetamidophenyl)-3-chlorobenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
4-methoxy-N-(5-methyl-3-isoxazolyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
4-tert-butyl-N-[4-(4-morpholinyl)phenyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(2-fluorophenyl)-4-phenylmethoxybenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
4-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
4-methyl-N-[4-(4-morpholinyl)phenyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
4-methoxy-N-(3-pyridinylmethyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
2-methoxy-N-(2-pyridinyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-[3-(4-oxo-3,1-benzoxazin-2-yl)phenyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-[(4-pyrimidinylthio)methyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(5-ethyl-1,3,4-thiadiazol-2-yl)-3-methoxybenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(4-acetamidophenyl)-2-bromobenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(5-acetyl-4-methyl-2-thiazolyl)-4-tert-butylbenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(5-acetyl-4-methyl-2-thiazolyl)-2-methylbenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
2-ethoxy-N-[5-(methoxymethyl)-1,3,4-thiadiazol-2-yl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(3,4-dimethoxyphenyl)-4-methoxybenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-[2-[(4-methylanilino)-oxomethyl]phenyl]-3-pyridinecarboxamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-[4-(2,5-dimethyl-1-pyrrolyl)phenyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-methoxybenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-[4-(2-methyl-4-thiazolyl)phenyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(3-acetamidophenyl)-2-chlorobenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
3-ethoxy-N-(2-thiazolyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
2-bromo-N-(3-methoxyphenyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(2,4-difluorophenyl)-3-methoxybenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
4-[[(4-acetyloxy-3-methoxyphenyl)-oxomethyl]amino]benzoic acid	0	benzamides		0	0		low	0	0	0	0	0	0
acetic acid [4-[(4-hydroxyanilino)-oxomethyl]-2-methoxyphenyl] ester	0	benzamides		0	0		low	0	0	0	0	0	0
N-(4-benzamido-2-chlorophenyl)-2-furancarboxamide	0	benzamides		0	0		low	0	0	0	0	0	0
2-(hydroxymethyl)-N-(phenylmethyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
2-[[(3-methylphenyl)-oxomethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid	0	benzamides		0	0		low	0	0	0	0	0	0
2-chloro-4-methyl-N-[4-(4-methyl-1-piperazinyl)phenyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
2-ethoxy-N-(2-hydroxyphenyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
3-[[(3-chloro-4-ethoxyphenyl)-oxomethyl]amino]benzoic acid	0	benzamides		0	0		low	0	0	0	0	0	0
2-methoxy-N-(4-methylphenyl)-4-(methylthio)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
3-[[(4-methoxyphenyl)-oxomethyl]amino]-2-thiophenecarboxylic acid methyl ester	0	benzamides		0	0		low	0	0	0	0	0	0
2-methoxy-3-methyl-N-[4-(4-morpholinylmethyl)phenyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(4-anilinophenyl)-3,4-dimethoxybenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-4-methylbenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-[[(6-methyl-4-pyrimidinyl)thio]methyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(3-acetamidophenyl)-2-methoxybenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
2-bromo-N-[3-(1-oxopropylamino)phenyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(3-acetylphenyl)-3-ethoxybenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
2-[[(3-bromophenyl)-oxomethyl]amino]-5-hydroxybenzoic acid	0	benzamides		0	0		low	0	0	0	0	0	0
1-azepanyl-[4-[(phenylthio)methyl]phenyl]methanone	0	benzamides		0	0		low	0	0	0	0	0	0
4-chloro-N-[4-(2-imidazo[1,2-a]pyridinyl)phenyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
3,4,5-triethoxy-N-(1H-1,2,4-triazol-5-yl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
3-[[[3-(4-methoxyphenyl)phenyl]-oxomethyl]amino]benzoic acid	0	benzamides		0	0		low	0	0	0	0	0	0
3-[(4-ethoxyphenoxy)methyl]-N,N-diethylbenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
2-[[anilino(oxo)methyl]amino]-N-(phenylmethyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
4-tert-butyl-N-(4-methyl-3-nitrophenyl)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(3-methoxyphenyl)-4-[(2-methyl-1-oxopropyl)amino]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-3,4,5-trimethoxybenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
4-chloro-3-[[(2-methyl-3-nitrophenyl)-oxomethyl]amino]benzoic acid methyl ester	0	benzamides		0	0		low	0	0	0	0	0	0
N-[3-chloro-4-(1-pyrrolidinyl)phenyl]-2-nitrobenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(4-methoxyphenyl)-2-(methylthio)benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-[3-[[(3,5-dimethoxyphenyl)-oxomethyl]amino]phenyl]carbamic acid ethyl ester	0	benzamides		0	0		low	0	0	0	0	0	0
2,4-dimethyl-N-[4-(1-pyrrolidinyl)phenyl]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0
N-(7-bromo-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)-3-methoxybenzamide	0	benzamides		0	0		low	0	0	0	0	0	0
5-chloro-N-(2-furanylmethyl)-2-[[(4-methoxyphenyl)-oxomethyl]amino]benzamide	0	benzamides		0	0		low	0	0	0	0	0	0

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
niacinamide	8	pyridine alkaloid; pyridinecarboxamide; vitamin B3	anti-inflammatory agent; antioxidant; cofactor; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; Escherichia coli metabolite; geroprotector; human urinary metabolite; metabolite; mouse metabolite; neuroprotective agent; Saccharomyces cerevisiae metabolite; Sir2 inhibitor	1995	2021	18.9	low	0	0	4	1	2	1
caffeic acid	0	catechols; hydroxycinnamic acid	antioxidant; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; EC 2.5.1.18 (glutathione transferase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; plant metabolite	0	0		low	0	0	0	0	0	0
carbamazepine	4	dibenzoazepine; ureas	analgesic; anticonvulsant; antimanic drug; drug allergen; EC 3.5.1.98 (histone deacetylase) inhibitor; environmental contaminant; glutamate transporter activator; mitogen; non-narcotic analgesic; sodium channel blocker; xenobiotic	1993	2016	15.8	low	0	0	1	1	2	0
ci 994	0	acetamides; benzamides; substituted aniline	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
valproic acid	14	branched-chain fatty acid; branched-chain saturated fatty acid	anticonvulsant; antimanic drug; EC 3.5.1.98 (histone deacetylase) inhibitor; GABA agent; neuroprotective agent; psychotropic drug; teratogenic agent	2012	2020	8.5	low	0	0	0	0	14	0
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamide	0	benzamides; hydroxamic acid; secondary carboxamide; tertiary amino compound	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
entinostat	0	benzamides; carbamate ester; primary amino compound; pyridines; substituted aniline	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
4-phenylbutyric acid	0	monocarboxylic acid	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor; prodrug	0	0		low	0	0	0	0	0	0
4-phenylbutyric acid, sodium salt	0	organic sodium salt	EC 3.5.1.98 (histone deacetylase) inhibitor; geroprotector; neuroprotective agent; orphan drug; prodrug	0	0		low	0	0	0	0	0	0
vorinostat	4	dicarboxylic acid diamide; hydroxamic acid	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	2009	2014	12.5	low	0	0	0	2	2	0
sulforaphane	0	isothiocyanate; sulfoxide	antineoplastic agent; antioxidant; EC 3.5.1.98 (histone deacetylase) inhibitor; plant metabolite	0	0		low	0	0	0	0	0	0
tributyrin	0	butyrate ester; triglyceride	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor; prodrug; protective agent	0	0		low	0	0	0	0	0	0
hc toxin	0	homodetic cyclic peptide; tetrapeptide	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor; metabolite; phytotoxin	0	0		low	0	0	0	0	0	0
trapoxin a	0	epoxide; homodetic cyclic peptide; ketone	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor; fungal metabolite	0	0		low	0	0	0	0	0	0
methylselenic acid	0	one-carbon compound; organoselenium compound	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor; human xenobiotic metabolite	0	0		low	0	0	0	0	0	0
trichostatin a	0	antibiotic antifungal agent; hydroxamic acid; trichostatin	bacterial metabolite; EC 3.5.1.98 (histone deacetylase) inhibitor; geroprotector	0	0		low	0	0	0	0	0	0
CHIC-35	0	aromatic compound; organic heterotricyclic compound; organochlorine compound; primary carboxamide	EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
curcumin	71	aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger	2003	2023	11.1	low	1	0	0	24	43	4
sirtinol	0	aldimine; benzamides; naphthols	anti-inflammatory agent; EC 3.5.1.98 (histone deacetylase) inhibitor; Sir2 inhibitor	0	0		low	0	0	0	0	0	0
sodium butyrate	0	organic sodium salt	EC 3.5.1.98 (histone deacetylase) inhibitor; geroprotector	0	0		low	0	0	0	0	0	0
romidepsin	0	cyclodepsipeptide; heterocyclic antibiotic; organic disulfide	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
3',4'-dihydroxyaurone	0	catechols; hydroxyaurone	EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
belinostat	0	hydroxamic acid; olefinic compound; sulfonamide	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
panobinostat	0	cinnamamides; hydroxamic acid; methylindole; secondary amino compound	angiogenesis modulating agent; antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
bml 210	0	dicarboxylic acid diamide	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
bl1521	0	enamide; hydroxamic acid; monocarboxylic acid amide	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
depudecin	0	polyketide	EC 3.5.1.98 (histone deacetylase) inhibitor; fungal metabolite	0	0		low	0	0	0	0	0	0
spiruchostatin b	0	macrocyclic lactone; organic disulfide; organic heterobicyclic compound; spiruchostatin	antineoplastic agent; bacterial metabolite; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
tubastatin a	0	hydroxamic acid; pyridoindole; tertiary amino compound	EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
pracinostat	0	benzimidazole; hydroxamic acid; olefinic compound; tertiary amino compound	antimalarial; antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0	0	0	0
protocatechuic acid	0	catechols; dihydroxybenzoic acid	antineoplastic agent; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor; human xenobiotic metabolite; plant metabolite	0	0		low	0	0	0	0	0	0
aminolevulinic acid	8	4-oxo monocarboxylic acid; amino acid zwitterion; delta-amino acid	antineoplastic agent; dermatologic drug; Escherichia coli metabolite; human metabolite; mouse metabolite; photosensitizing agent; plant metabolite; prodrug; Saccharomyces cerevisiae metabolite	1987	2022	16.1	low	0	1	1	2	3	1
gallic acid	23	trihydroxybenzoic acid	antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite	1981	2023	15.3	low	0	2	2	6	9	4
perillic acid	0	alpha,beta-unsaturated monocarboxylic acid; cyclohexenecarboxylic acid	antineoplastic agent; human metabolite; mouse metabolite	0	0		low	0	0	0	0	0	0
pk 11195	0	aromatic amide; isoquinolines; monocarboxylic acid amide; monochlorobenzenes	antineoplastic agent	0	0		low	0	0	0	0	0	0
pd 173074	0	aromatic amine; biaryl; dimethoxybenzene; pyridopyrimidine; tertiary amino compound; ureas	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; fibroblast growth factor receptor antagonist	0	0		low	0	0	0	0	0	0
aminopropionitrile	0	aminopropionitrile	antineoplastic agent; antirheumatic drug; collagen cross-linking inhibitor; plant metabolite	0	0		low	0	0	0	0	0	0
5-(n,n-hexamethylene)amiloride	0	aromatic amine; azepanes; guanidines; monocarboxylic acid amide; organochlorine compound; pyrazines	antineoplastic agent; apoptosis inducer; odorant receptor antagonist; sodium channel blocker	0	0		low	0	0	0	0	0	0
7,8-dihydroxyflavone	0	dihydroxyflavone	antidepressant; antineoplastic agent; antioxidant; plant metabolite; tropomyosin-related kinase B receptor agonist	0	0		low	0	0	0	0	0	0
ro 48-8071	0	aromatic ether; aromatic ketone; bromobenzenes; monofluorobenzenes; olefinic compound; tertiary amino compound	antineoplastic agent; EC 5.4.99.7 (lanosterol synthase) inhibitor	0	0		low	0	0	0	0	0	0
rtki cpd	0	aromatic ether; monochlorobenzenes; quinazolines	antineoplastic agent; antiviral agent; epidermal growth factor receptor antagonist; geroprotector	0	0		low	0	0	0	0	0	0
alfuzosin	0	monocarboxylic acid amide; quinazolines; tetrahydrofuranol	alpha-adrenergic antagonist; antihypertensive agent; antineoplastic agent	0	0		low	0	0	0	0	0	0
am 251	0	amidopiperidine; carbohydrazide; dichlorobenzene; organoiodine compound; pyrazoles	antidepressant; antineoplastic agent; apoptosis inducer; CB1 receptor antagonist	0	0		low	0	0	0	0	0	0
am 580	0	amidobenzoic acid; tetralins	antineoplastic agent; retinoic acid receptor alpha/beta agonist	0	0		low	0	0	0	0	0	0
aminoglutethimide	3	dicarboximide; piperidones; substituted aniline	adrenergic agent; anticonvulsant; antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor	2006	2015	14.7	low	0	0	0	2	1	0
amsacrine	1	acridines; aromatic ether; sulfonamide	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor	1992	1992	32.0	low	0	0	1	0	0	0
anastrozole	0	nitrile; triazoles	antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor	0	0		low	0	0	0	0	0	0
azathioprine	19	aryl sulfide; C-nitro compound; imidazoles; thiopurine	antimetabolite; antineoplastic agent; carcinogenic agent; DNA synthesis inhibitor; hepatotoxic agent; immunosuppressive agent; prodrug	1988	2021	15.2	low	3	1	3	6	8	1
azelaic acid	0	alpha,omega-dicarboxylic acid; dicarboxylic fatty acid	antibacterial agent; antineoplastic agent; dermatologic drug; plant metabolite	0	0		low	0	0	0	0	0	0
berberine	14	alkaloid antibiotic; berberine alkaloid; botanical anti-fungal agent; organic heteropentacyclic compound	antilipemic drug; antineoplastic agent; antioxidant; EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor; EC 1.21.3.3 (reticuline oxidase) inhibitor; EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor; EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor; EC 2.7.11.10 (IkappaB kinase) inhibitor; EC 3.1.1.4 (phospholipase A2) inhibitor; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor; EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; geroprotector; hypoglycemic agent; metabolite; potassium channel blocker	1993	2021	12.0	low	0	0	2	1	10	1
buformin	0	biguanides	antineoplastic agent; antiviral agent; geroprotector; hypoglycemic agent; radiosensitizing agent	0	0		low	0	0	0	0	0	0
busulfan	2	methanesulfonate ester	alkylating agent; antineoplastic agent; carcinogenic agent; insect sterilant; teratogenic agent	2014	2022	6.0	low	0	0	0	0	1	1
camostat	0	benzoate ester; carboxylic ester; diester; guanidines; tertiary carboxamide	anti-inflammatory agent; anticoronaviral agent; antifibrinolytic drug; antihypertensive agent; antineoplastic agent; antiviral agent; serine protease inhibitor	0	0		low	0	0	0	0	0	0
carmustine	3	N-nitrosoureas; organochlorine compound	alkylating agent; antineoplastic agent	1983	1992	37.0	low	0	2	1	0	0	0
cgs 15943	0	aromatic amine; biaryl; furans; organochlorine compound; primary amino compound; quinazolines; triazoloquinazoline	adenosine A1 receptor antagonist; adenosine A2A receptor antagonist; antineoplastic agent; central nervous system stimulant	0	0		low	0	0	0	0	0	0
chelerythrine	0	benzophenanthridine alkaloid; organic cation	antibacterial agent; antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor	0	0		low	0	0	0	0	0	0
chlorambucil	0	aromatic amine; monocarboxylic acid; nitrogen mustard; organochlorine compound; tertiary amino compound	alkylating agent; antineoplastic agent; carcinogenic agent; drug allergen; immunosuppressive agent	0	0		low	0	0	0	0	0	0
ciglitazone	0	aromatic ether; thiazolidinone	antineoplastic agent; insulin-sensitizing drug	0	0		low	0	0	0	0	0	0
cl 387785	0	bromobenzenes; quinazolines; secondary carboxamide; ynamide	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; epidermal growth factor receptor antagonist	0	0		low	0	0	0	0	0	0
clioquinol	0	monohydroxyquinoline; organochlorine compound; organoiodine compound	antibacterial agent; antifungal agent; antimicrobial agent; antineoplastic agent; antiprotozoal drug; chelator; copper chelator	0	0		low	0	0	0	0	0	0
clofibric acid	0	aromatic ether; monocarboxylic acid; monochlorobenzenes	anticholesteremic drug; antilipemic drug; antineoplastic agent; herbicide; marine xenobiotic metabolite; PPARalpha agonist	0	0		low	0	0	0	0	0	0
dacarbazine	0	imidazoles; monocarboxylic acid amide; triazene derivative	alkylating agent; antineoplastic agent; carcinogenic agent; prodrug	0	0		low	0	0	0	0	0	0
dequalinium	0	quinolinium ion	antifungal agent; antineoplastic agent; antiseptic drug; mitochondrial NADH:ubiquinone reductase inhibitor	0	0		low	0	0	0	0	0	0
3,3'-diindolylmethane	0	indoles	antineoplastic agent; P450 inhibitor	0	0		low	0	0	0	0	0	0
disulfiram	3	organic disulfide; organosulfur acaricide	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor; EC 3.1.1.1 (carboxylesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 5.99.1.2 (DNA topoisomerase) inhibitor; ferroptosis inducer; fungicide; NF-kappaB inhibitor	1950	2010	36.7	low	0	1	0	2	0	0
doxazosin	0	aromatic amine; benzodioxine; monocarboxylic acid amide; N-acylpiperazine; N-arylpiperazine; quinazolines	alpha-adrenergic antagonist; antihyperplasia drug; antihypertensive agent; antineoplastic agent; vasodilator agent	0	0		low	0	0	0	0	0	0
ebselen	0	benzoselenazole	anti-inflammatory drug; antibacterial agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antioxidant; apoptosis inducer; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; EC 3.5.4.1 (cytosine deaminase) inhibitor; EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor; enzyme mimic; ferroptosis inhibitor; genotoxin; hepatoprotective agent; neuroprotective agent; radical scavenger	0	0		low	0	0	0	0	0	0
ellipticine	0	indole alkaloid; organic heterotetracyclic compound; organonitrogen heterocyclic compound; polycyclic heteroarene	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
embelin	0	dihydroxy-1,4-benzoquinones	antimicrobial agent; antineoplastic agent; hepatitis C protease inhibitor; plant metabolite	0	0		low	0	0	0	0	0	0
emodin	12	trihydroxyanthraquinone	antineoplastic agent; laxative; plant metabolite; tyrosine kinase inhibitor	2007	2022	11.2	low	0	0	0	5	6	1
etanidazole	0	C-nitro compound; imidazoles; monocarboxylic acid amide	alkylating agent; antineoplastic agent; prodrug; radiosensitizing agent	0	0		low	0	0	0	0	0	0
etidronate	1	1,1-bis(phosphonic acid)	antineoplastic agent; bone density conservation agent; chelator	1993	1993	31.0	low	0	0	1	0	0	0
fluorouracil	40	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic	1992	2022	13.5	low	1	0	4	13	21	2
flutamide	7	(trifluoromethyl)benzenes; monocarboxylic acid amide	androgen antagonist; antineoplastic agent	1983	2009	22.6	low	0	1	1	5	0	0
miltefosine	0	phosphocholines; phospholipid	anti-inflammatory agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antiprotozoal drug; apoptosis inducer; immunomodulator; protein kinase inhibitor	0	0		low	0	0	0	0	0	0
beta-thujaplicin	0	cyclic ketone; enol; monoterpenoid	antibacterial agent; antifungal agent; antineoplastic agent; antiplasmodial drug; plant metabolite	0	0		low	0	0	0	0	0	0
hydroxyurea	16	one-carbon compound; ureas	antimetabolite; antimitotic; antineoplastic agent; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; genotoxin; immunomodulator; radical scavenger; teratogenic agent	1984	2019	26.7	low	1	5	6	4	1	0
ifosfamide	1	ifosfamides	alkylating agent; antineoplastic agent; environmental contaminant; immunosuppressive agent; xenobiotic	2007	2007	17.0	low	0	0	0	1	0	0
indole-3-carbinol	0	indolyl alcohol	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
beta-lapachone	0	benzochromenone; orthoquinones	anti-inflammatory agent; antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
leflunomide	6	(trifluoromethyl)benzenes; isoxazoles; monocarboxylic acid amide	antineoplastic agent; antiparasitic agent; EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; hepatotoxic agent; immunosuppressive agent; non-steroidal anti-inflammatory drug; prodrug; pyrimidine synthesis inhibitor; tyrosine kinase inhibitor	1995	2015	16.3	low	0	0	1	4	1	0
letrozole	1	nitrile; triazoles	antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor	2017	2017	7.0	low	0	0	0	0	1	0
lomustine	0	N-nitrosoureas; organochlorine compound	alkylating agent; antineoplastic agent	0	0		low	0	0	0	0	0	0
6-anilino-5,8-quinolinedione	0	aminoquinoline; aromatic amine; p-quinones; quinolone	antineoplastic agent; EC 4.6.1.2 (guanylate cyclase) inhibitor	0	0		low	0	0	0	0	0	0
meclofenamic acid	2	aminobenzoic acid; organochlorine compound; secondary amino compound	analgesic; anticonvulsant; antineoplastic agent; antipyretic; antirheumatic drug; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-steroidal anti-inflammatory drug	1992	1995	30.5	low	0	0	2	0	0	0
vitamin k 3	3	1,4-naphthoquinones; vitamin K	angiogenesis inhibitor; antineoplastic agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; human urinary metabolite; nutraceutical	2005	2021	9.0	low	0	0	0	1	1	1
methoxsalen	1	aromatic ether; psoralens	antineoplastic agent; cross-linking reagent; dermatologic drug; photosensitizing agent; plant metabolite	2019	2019	5.0	low	0	0	0	0	1	0
nocodazole	0	aromatic ketone; benzimidazoles; carbamate ester; thiophenes	antimitotic; antineoplastic agent; microtubule-destabilising agent; tubulin modulator	0	0		low	0	0	0	0	0	0
midazolam	2	imidazobenzodiazepine; monofluorobenzenes; organochlorine compound	anticonvulsant; antineoplastic agent; anxiolytic drug; apoptosis inducer; central nervous system depressant; GABAA receptor agonist; general anaesthetic; muscle relaxant; sedative	1995	2005	24.0	low	0	0	1	1	0	0
mitoxantrone	6	dihydroxyanthraquinone	analgesic; antineoplastic agent	1992	2017	23.0	low	0	0	3	2	1	0
n(1), n(12)-diethylspermine	0	polyazaalkane; secondary amino compound; substituted spermine; tetramine	antineoplastic agent	0	0		low	0	0	0	0	0	0
nilutamide	0	(trifluoromethyl)benzenes; C-nitro compound; imidazolidinone	androgen antagonist; antineoplastic agent	0	0		low	0	0	0	0	0	0
nortriptyline	0	organic tricyclic compound; secondary amine	adrenergic uptake inhibitor; analgesic; antidepressant; antineoplastic agent; apoptosis inducer; drug metabolite	0	0		low	0	0	0	0	0	0
n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0	aromatic ether; C-nitro compound; sulfonamide	antineoplastic agent; cyclooxygenase 2 inhibitor	0	0		low	0	0	0	0	0	0
oxyphenbutazone	0	phenols; pyrazolidines	antimicrobial agent; antineoplastic agent; antipyretic; drug metabolite; gout suppressant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic metabolite	0	0		low	0	0	0	0	0	0
pd 158780	0	aromatic amine; bromobenzenes; diamine; pyridopyrimidine; secondary amino compound	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	0	0		low	0	0	0	0	0	0
oxophenylarsine	0	arsine oxides	antineoplastic agent; apoptosis inducer; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor	0	0		low	0	0	0	0	0	0
phloretin	1	dihydrochalcones	antineoplastic agent; plant metabolite	2016	2016	8.0	low	0	0	0	0	1	0
pipobroman	0	N-acylpiperazine; organobromine compound; tertiary carboxamide	alkylating agent; antineoplastic agent	0	0		low	0	0	0	0	0	0
pj-34	0	phenanthridines; secondary carboxamide; tertiary amino compound	angiogenesis inhibitor; anti-inflammatory agent; antiatherosclerotic agent; antineoplastic agent; apoptosis inducer; cardioprotective agent; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; neuroprotective agent	0	0		low	0	0	0	0	0	0
procarbazine	2	benzamides; hydrazines	antineoplastic agent	1991	1993	32.0	low	0	0	2	0	0	0
salicylsalicylic acid	0	benzoate ester; benzoic acids; phenols; salicylates	antineoplastic agent; antirheumatic drug; EC 3.5.2.6 (beta-lactamase) inhibitor; hypoglycemic agent; non-narcotic analgesic; non-steroidal anti-inflammatory drug; prodrug	0	0		low	0	0	0	0	0	0
semustine	0	N-nitrosoureas; organochlorine compound	alkylating agent; antineoplastic agent; carcinogenic agent	0	0		low	0	0	0	0	0	0
imatinib	0	aromatic amine; benzamides; N-methylpiperazine; pyridines; pyrimidines	antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor	0	0		low	0	0	0	0	0	0
streptonigrin	0	pyridines; quinolone	antimicrobial agent; antineoplastic agent	0	0		low	0	0	0	0	0	0
SU6656	0	oxindoles; sulfonamide	antineoplastic agent; Aurora kinase inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor	0	0		low	0	0	0	0	0	0
suramin	2	naphthalenesulfonic acid; phenylureas; secondary carboxamide	angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug	1996	2019	16.5	low	0	0	1	0	1	0
temozolomide	0	imidazotetrazine; monocarboxylic acid amide; triazene derivative	alkylating agent; antineoplastic agent; prodrug	0	0		low	0	0	0	0	0	0
terazosin	0	furans; piperazines; primary amino compound; quinazolines	alpha-adrenergic antagonist; antihypertensive agent; antineoplastic agent	0	0		low	0	0	0	0	0	0
2,2'-thiodiethanol	0	aliphatic sulfide; diol	antineoplastic agent; antioxidant; metabolite; solvent	0	0		low	0	0	0	0	0	0
tilorone	0	aromatic ether; diether; fluoren-9-ones; tertiary amino compound	anti-inflammatory agent; antineoplastic agent; antiviral agent; interferon inducer; nicotinic acetylcholine receptor agonist	0	0		low	0	0	0	0	0	0
troglitazone	2	chromanes; thiazolidinone	anticoagulant; anticonvulsant; antineoplastic agent; antioxidant; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; hypoglycemic agent; platelet aggregation inhibitor; vasodilator agent	2004	2005	19.5	low	0	0	0	2	0	0
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	0	aromatic primary alcohol; furans; indazoles	antineoplastic agent; apoptosis inducer; platelet aggregation inhibitor; soluble guanylate cyclase activator; vasodilator agent	0	0		low	0	0	0	0	0	0
mitomycin	6	mitomycin	alkylating agent; antineoplastic agent	1995	2023	19.2	low	1	0	2	3	0	1
prednisolone	121	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antineoplastic agent; drug metabolite; environmental contaminant; immunosuppressive agent; xenobiotic	1959	2022	18.5	low	6	5	29	49	35	3
floxuridine	0	nucleoside analogue; organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; radiosensitizing agent	0	0		low	0	0	0	0	0	0
prednisone	25	11-oxo steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antineoplastic agent; immunosuppressive agent; prodrug	1956	2022	20.5	low	2	5	4	6	7	3
estrone	5	17-oxo steroid; 3-hydroxy steroid; phenolic steroid; phenols	antineoplastic agent; bone density conservation agent; estrogen; human metabolite; mouse metabolite	1961	1989	52.0	low	0	5	0	0	0	0
azauridine	0	N-glycosyl-1,2,4-triazine	antimetabolite; antineoplastic agent; drug metabolite	0	0		low	0	0	0	0	0	0
mechlorethamine hydrochloride	0	hydrochloride	antineoplastic agent	0	0		low	0	0	0	0	0	0
allyl isothiocyanate	0	alkenyl isothiocyanate; isothiocyanate	antimicrobial agent; antineoplastic agent; apoptosis inducer; lachrymator; metabolite	0	0		low	0	0	0	0	0	0
vincristine	0	acetate ester; formamides; methyl ester; organic heteropentacyclic compound; organic heterotetracyclic compound; tertiary alcohol; tertiary amino compound; vinca alkaloid	antineoplastic agent; drug; microtubule-destabilising agent; plant metabolite; tubulin modulator	0	0		low	0	0	0	0	0	0
methyltestosterone	0	17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; enone	anabolic agent; androgen; antineoplastic agent	0	0		low	0	0	0	0	0	0
dromostanolone	0	17beta-hydroxy steroid; 3-oxo-5alpha-steroid; anabolic androgenic steroid	anabolic agent; antineoplastic agent	0	0		low	0	0	0	0	0	0
bromodeoxyuridine	6	pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent	1993	2014	21.8	low	0	0	3	2	1	0
ethyl methanesulfonate	3	methanesulfonate ester	alkylating agent; antineoplastic agent; carcinogenic agent; genotoxin; mutagen; teratogenic agent	1990	2001	27.0	low	0	0	2	1	0	0
triaziquone	0	1,4-benzoquinones; aziridines	alkylating agent; antineoplastic agent	0	0		low	0	0	0	0	0	0
tubercidin	1	antibiotic antifungal agent; N-glycosylpyrrolopyrimidine; ribonucleoside	antimetabolite; antineoplastic agent; bacterial metabolite	1986	1986	38.0	low	0	1	0	0	0	0
cytarabine	23	beta-D-arabinoside; monosaccharide derivative; pyrimidine nucleoside	antimetabolite; antineoplastic agent; antiviral agent; immunosuppressive agent	1986	2019	24.5	low	1	3	9	8	3	0
trifluridine	1	nucleoside analogue; organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; EC 2.1.1.45 (thymidylate synthase) inhibitor	2023	2023	1.0	low	1	0	0	0	0	1
medroxyprogesterone acetate	2	20-oxo steroid; 3-oxo-Delta(4) steroid; acetate ester; corticosteroid; steroid ester	adjuvant; androgen; antineoplastic agent; antioxidant; female contraceptive drug; inhibitor; progestin; synthetic oral contraceptive	2005	2012	15.5	low	0	0	0	1	1	0
fluoxymesterone	0	11beta-hydroxy steroid; 17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; anabolic androgenic steroid; fluorinated steroid	anabolic agent; antineoplastic agent	0	0		low	0	0	0	0	0	0
rotenone	9	organic heteropentacyclic compound; rotenones	antineoplastic agent; metabolite; mitochondrial NADH:ubiquinone reductase inhibitor; phytogenic insecticide; piscicide; toxin	1988	2019	16.7	low	0	1	0	4	4	0
acetopyrrothine	0	acetamides; dithiolopyrrolone antibiotic	angiogenesis inhibitor; antibacterial agent; antifungal agent; antineoplastic agent; bacterial metabolite; chelator; EC 2.7.7.6 (RNA polymerase) inhibitor; marine metabolite; protein synthesis inhibitor; toxin	0	0		low	0	0	0	0	0	0
phenformin	0	biguanides	antineoplastic agent; geroprotector; hypoglycemic agent	0	0		low	0	0	0	0	0	0
dibenzoylmethane	0	aromatic ketone; beta-diketone	antimutagen; antineoplastic agent; metabolite	0	0		low	0	0	0	0	0	0
suramin sodium	0	organic sodium salt	angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug	0	0		low	0	0	0	0	0	0
pyrazolanthrone	0	anthrapyrazole; aromatic ketone; cyclic ketone	antineoplastic agent; c-Jun N-terminal kinase inhibitor; geroprotector	0	0		low	0	0	0	0	0	0
diazooxonorleucine	2	amino acid zwitterion; diazo compound; ketone; non-proteinogenic L-alpha-amino acid	analgesic; antibacterial agent; antimetabolite; antineoplastic agent; antiviral agent; apoptosis inducer; bacterial metabolite; EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitor; EC 3.5.1.2 (glutaminase) inhibitor; EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitor; EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitor; EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitor; EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitor; EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitor; EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitor; glutamine antagonist	2007	2008	16.5	low	0	0	0	2	0	0
azacitidine	1	N-glycosyl-1,3,5-triazine; nucleoside analogue	antineoplastic agent	2017	2017	7.0	low	0	0	0	0	1	0
diazomethane	0	diazo compound	alkylating agent; antineoplastic agent; carcinogenic agent; poison	0	0		low	0	0	0	0	0	0
procarbazine hydrochloride	0	hydrochloride	antineoplastic agent	0	0		low	0	0	0	0	0	0
naphthazarin	0	hydroxy-1,4-naphthoquinone	acaricide; antibacterial agent; antineoplastic agent; apoptosis inducer; geroprotector; plant metabolite	0	0		low	0	0	0	0	0	0
liriodenine	0	alkaloid antibiotic; cyclic ketone; organic heteropentacyclic compound; oxacycle; oxoaporphine alkaloid	antifungal agent; antimicrobial agent; antineoplastic agent; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; metabolite	0	0		low	0	0	0	0	0	0
lucanthone	0	thioxanthenes	adjuvant; antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; mutagen; photosensitizing agent; prodrug; schistosomicide drug	0	0		low	0	0	0	0	0	0
plumbagin	0	hydroxy-1,4-naphthoquinone; phenols	anticoagulant; antineoplastic agent; immunological adjuvant; metabolite	0	0		low	0	0	0	0	0	0
aloe emodin	0	aromatic primary alcohol; dihydroxyanthraquinone	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
emetine	1	isoquinoline alkaloid; pyridoisoquinoline	antiamoebic agent; anticoronaviral agent; antiinfective agent; antimalarial; antineoplastic agent; antiprotozoal drug; antiviral agent; autophagy inhibitor; emetic; expectorant; plant metabolite; protein synthesis inhibitor	2000	2000	24.0	low	0	0	1	0	0	0
thymoquinone	0	1,4-benzoquinones	adjuvant; anti-inflammatory agent; antidepressant; antineoplastic agent; antioxidant; cardioprotective agent; plant metabolite	0	0		low	0	0	0	0	0	0
podophyllotoxin	0	furonaphthodioxole; lignan; organic heterotetracyclic compound	antimitotic; antineoplastic agent; keratolytic drug; microtubule-destabilising agent; plant metabolite; tubulin modulator	0	0		low	0	0	0	0	0	0
physcione	0	dihydroxyanthraquinone	anti-inflammatory agent; antibacterial agent; antifungal agent; antineoplastic agent; apoptosis inducer; hepatoprotective agent; metabolite	0	0		low	0	0	0	0	0	0
dequalinium chloride	0	organic chloride salt	antifungal agent; antineoplastic agent; antiseptic drug; mitochondrial NADH:ubiquinone reductase inhibitor	0	0		low	0	0	0	0	0	0
4-methyl-1-(1-methylethyl)-3-cyclohexen-1-ol	0	terpineol; tertiary alcohol	anti-inflammatory agent; antibacterial agent; antineoplastic agent; antioxidant; antiparasitic agent; apoptosis inducer; plant metabolite; volatile oil component	0	0		low	0	0	0	0	0	0
formestane	0	17-oxo steroid; 3-oxo-Delta(4) steroid; enol; hydroxy steroid	antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor	0	0		low	0	0	0	0	0	0
chlorotrianisene	0	chloroalkene	antineoplastic agent; estrogen receptor modulator; xenoestrogen	0	0		low	0	0	0	0	0	0
megestrol acetate	0	20-oxo steroid; 3-oxo-Delta(4) steroid; acetate ester; steroid ester	antineoplastic agent; appetite enhancer; contraceptive drug; progestin; synthetic oral contraceptive	0	0		low	0	0	0	0	0	0
toyocamycin	0	antibiotic antifungal agent; N-glycosylpyrrolopyrimidine; nitrile; ribonucleoside	antimetabolite; antineoplastic agent; apoptosis inducer; bacterial metabolite	0	0		low	0	0	0	0	0	0
2-hydroxyacetanilide	0	acetamides; phenols	anti-inflammatory agent; antineoplastic agent; antirheumatic drug; apoptosis inducer; platelet aggregation inhibitor; xenobiotic metabolite	0	0		low	0	0	0	0	0	0
methoxyacetic acid	0	ether; monocarboxylic acid	antineoplastic agent; apoptosis inducer; human xenobiotic metabolite; mutagen	0	0		low	0	0	0	0	0	0
hadacidin	0	aldehyde; monocarboxylic acid; N-hydroxy-alpha-amino-acid	antimicrobial agent; antineoplastic agent; Penicillium metabolite; teratogenic agent	0	0		low	0	0	0	0	0	0
2-fluoroadenine	0	organofluorine compound; purines	antineoplastic agent	0	0		low	0	0	0	0	0	0
tetramethylpyrazine	0	alkaloid; pyrazines	antineoplastic agent; apoptosis inhibitor; bacterial metabolite; neuroprotective agent; platelet aggregation inhibitor; vasodilator agent	0	0		low	0	0	0	0	0	0
guanazole	1	aromatic amine; triazoles	antineoplastic agent; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor	1984	1984	40.0	low	0	1	0	0	0	0
diallyl trisulfide	0	organic trisulfide	anti-inflammatory agent; antilipemic drug; antineoplastic agent; antioxidant; antiprotozoal drug; apoptosis inducer; estrogen receptor antagonist; insecticide; platelet aggregation inhibitor; vasodilator agent	0	0		low	0	0	0	0	0	0
diallyl disulfide	0	organic disulfide	antifungal agent; antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
phenethyl isothiocyanate	0	isothiocyanate	antineoplastic agent; EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor; metabolite	0	0		low	0	0	0	0	0	0
glaucine	0	aporphine alkaloid; organic heterotetracyclic compound; polyether; tertiary amino compound	antibacterial agent; antineoplastic agent; antitussive; muscle relaxant; NF-kappaB inhibitor; plant metabolite; platelet aggregation inhibitor; rat metabolite	0	0		low	0	0	0	0	0	0
acadesine	0	1-ribosylimidazolecarboxamide; aminoimidazole; nucleoside analogue	antineoplastic agent; platelet aggregation inhibitor	0	0		low	0	0	0	0	0	0
doxifluridine	0	organofluorine compound; pyrimidine 5'-deoxyribonucleoside	antimetabolite; antineoplastic agent; prodrug	0	0		low	0	0	0	0	0	0
megestrol	0	17alpha-hydroxy steroid; 20-oxo steroid; 3-oxo-Delta(4) steroid; tertiary alpha-hydroxy ketone	antineoplastic agent; appetite enhancer; contraceptive drug; progestin; synthetic oral contraceptive	0	0		low	0	0	0	0	0	0
mitomycin a	0	ether; mitomycin	alkylating agent; antimicrobial agent; antineoplastic agent; toxin	0	0		low	0	0	0	0	0	0
cladribine	0	organochlorine compound; purine 2'-deoxyribonucleoside	antineoplastic agent; immunosuppressive agent	0	0		low	0	0	0	0	0	0
tabersonine	0	alkaloid ester; methyl ester; monoterpenoid indole alkaloid; organic heteropentacyclic compound	antineoplastic agent; metabolite	0	0		low	0	0	0	0	0	0
vidarabine	1	beta-D-arabinoside; purine nucleoside	antineoplastic agent; bacterial metabolite; nucleoside antibiotic	2004	2004	20.0	low	0	0	0	1	0	0
cyclophosphamide	0	hydrate	alkylating agent; antineoplastic agent; carcinogenic agent; immunosuppressive agent	0	0		low	0	0	0	0	0	0
helenalin	0	cyclic ketone; gamma-lactone; organic heterotricyclic compound; secondary alcohol; sesquiterpene lactone	anti-inflammatory agent; antineoplastic agent; metabolite; plant metabolite	0	0		low	0	0	0	0	0	0
etidronate disodium	0	organic sodium salt	antineoplastic agent; bone density conservation agent; chelator	0	0		low	0	0	0	0	0	0
camptothecin	8	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite	2008	2020	8.6	low	0	0	0	1	7	0
isopentenyladenosine	0	N-ribosyl-N(6)-isopentenyladenine; nucleoside analogue	antineoplastic agent; plant growth regulator; plant metabolite	0	0		low	0	0	0	0	0	0
nsc-145,668	0	hydrochloride	antimetabolite; antineoplastic agent	0	0		low	0	0	0	0	0	0
ancitabine	0	diol; organic heterotricyclic compound	antimetabolite; antineoplastic agent; prodrug	0	0		low	0	0	0	0	0	0
clodronic acid	5	1,1-bis(phosphonic acid); one-carbon compound; organochlorine compound	antineoplastic agent; bone density conservation agent	1990	2012	25.0	low	0	0	3	1	1	0
tetradecanoylphorbol acetate	344	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator	1980	2022	25.9	low	1	83	129	71	57	4
streptozocin	0	N-acylglucosamine; N-nitrosoureas	antimicrobial agent; antineoplastic agent; DNA synthesis inhibitor; metabolite	0	0		low	0	0	0	0	0	0
daunorubicin	11	aminoglycoside antibiotic; anthracycline; p-quinones; tetracenequinones	antineoplastic agent; bacterial metabolite	1986	2010	24.5	low	1	1	3	7	0	0
fludarabine phosphate	0	nucleoside analogue; organofluorine compound; purine arabinonucleoside monophosphate	antimetabolite; antineoplastic agent; antiviral agent; DNA synthesis inhibitor; immunosuppressive agent; prodrug	0	0		low	0	0	0	0	0	0
2,6-diaminopurine	0	2,6-diaminopurines; primary amino compound	antineoplastic agent	0	0		low	0	0	0	0	0	0
silybin	0	aromatic ether; benzodioxine; flavonolignan; polyphenol; secondary alpha-hydroxy ketone	antineoplastic agent; antioxidant; hepatoprotective agent; plant metabolite	0	0		low	0	0	0	0	0	0
glucaric acid	1	glucaric acid	antineoplastic agent	2012	2012	12.0	low	0	0	0	0	1	0
paclitaxel	3	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent	2004	2012	16.3	low	1	0	0	2	1	0
etoposide	13	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor	1994	2017	18.2	low	1	0	2	8	3	0
promegestone	0	20-oxo steroid; 3-oxo-Delta(4) steroid	antineoplastic agent; progesterone receptor agonist; progestin	0	0		low	0	0	0	0	0	0
perfosfamide	0	nitrogen mustard; organochlorine compound; peroxol; phosphorodiamide	alkylating agent; antineoplastic agent; drug allergen; immunosuppressive agent; metabolite	0	0		low	0	0	0	0	0	0
nimustine	0	aminopyrimidine; N-nitrosoureas; organochlorine compound	alkylating agent; antineoplastic agent	0	0		low	0	0	0	0	0	0
lonidamine	0	dichlorobenzene; indazoles; monocarboxylic acid	antineoplastic agent; antispermatogenic agent; EC 2.7.1.1 (hexokinase) inhibitor; geroprotector	0	0		low	0	0	0	0	0	0
vindesine	0	methyl ester; organic heteropentacyclic compound; organic heterotetracyclic compound; primary carboxamide; tertiary alcohol; tertiary amino compound; vinca alkaloid	antineoplastic agent	0	0		low	0	0	0	0	0	0
epirubicin	0	aminoglycoside; anthracycline antibiotic; anthracycline; deoxy hexoside; monosaccharide derivative; p-quinones; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	antimicrobial agent; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor	0	0		low	0	0	0	0	0	0
diaziquone	0	1,4-benzoquinones; aziridines; carbamate ester; enamine	alkylating agent; antineoplastic agent	0	0		low	0	0	0	0	0	0
midazolam hydrochloride	0	hydrochloride; imidazobenzodiazepine	anticonvulsant; antineoplastic agent; anxiolytic drug; apoptosis inducer; central nervous system depressant; GABAA receptor agonist; general anaesthetic; muscle relaxant; sedative	0	0		low	0	0	0	0	0	0
oltipraz	0	1,2-dithiole; pyrazines	angiogenesis modulating agent; antimutagen; antineoplastic agent; antioxidant; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor; neurotoxin; protective agent; schistosomicide drug	0	0		low	0	0	0	0	0	0
fazarabine	0	N-glycosyl-1,3,5-triazine; nucleoside analogue	antineoplastic agent	0	0		low	0	0	0	0	0	0
mitoxantrone hydrochloride	0	hydrochloride	antineoplastic agent	0	0		low	0	0	0	0	0	0
bisantrene	0	anthracenes; hydrazone; imidazolidines	antineoplastic agent	0	0		low	0	0	0	0	0	0
swainsonine	0	indolizidine alkaloid	antineoplastic agent; EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) inhibitor; immunological adjuvant; plant metabolite	0	0		low	0	0	0	0	0	0
lovastatin	0	delta-lactone; fatty acid ester; hexahydronaphthalenes; polyketide; statin (naturally occurring)	anticholesteremic drug; antineoplastic agent; Aspergillus metabolite; prodrug	0	0		low	0	0	0	0	0	0
cabergoline	0	N-acylurea	antineoplastic agent; antiparkinson drug; dopamine agonist	0	0		low	0	0	0	0	0	0
nitrogenase stabilizing-protective protein, bacteria	0	N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide	androgen antagonist; antineoplastic agent	0	0		low	0	0	0	0	0	0
bmy 25067	0	C-nitro compound; organic disulfide	antineoplastic agent	0	0		low	0	0	0	0	0	0
brequinar	0	biphenyls; monocarboxylic acid; monofluorobenzenes; quinolinemonocarboxylic acid	anticoronaviral agent; antimetabolite; antineoplastic agent; antiviral agent; EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor; immunosuppressive agent; pyrimidine synthesis inhibitor	0	0		low	0	0	0	0	0	0
imiquimod	5	imidazoquinoline	antineoplastic agent; interferon inducer	2012	2021	7.6	low	0	0	0	0	4	1
aromasil	0	17-oxo steroid; 3-oxo-Delta(1),Delta(4)-steroid	antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor; environmental contaminant; xenobiotic	0	0		low	0	0	0	0	0	0
cidofovir anhydrous	0	phosphonic acids; pyrimidone	anti-HIV agent; antineoplastic agent; antiviral drug; photosensitizing agent	0	0		low	0	0	0	0	0	0
topotecan	2	pyranoindolizinoquinoline	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor	2017	2018	6.5	low	0	0	0	0	2	0
gemcitabine hydrochloride	0	hydrochloride; organofluorine compound	anticoronaviral agent; antimetabolite; antineoplastic agent; antiviral drug; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; immunosuppressive agent; radiosensitizing agent	0	0		low	0	0	0	0	0	0
gemcitabine	1	organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; environmental contaminant; immunosuppressive agent; photosensitizing agent; prodrug; radiosensitizing agent; xenobiotic	2022	2022	2.0	low	0	0	0	0	0	1
irinotecan	8	carbamate ester; delta-lactone; N-acylpiperidine; pyranoindolizinoquinoline; ring assembly; tertiary alcohol; tertiary amino compound	antineoplastic agent; apoptosis inducer; EC 5.99.1.2 (DNA topoisomerase) inhibitor; prodrug	2008	2021	8.5	low	0	0	0	1	6	1
capecitabine	1	carbamate ester; cytidines; organofluorine compound	antimetabolite; antineoplastic agent; prodrug	2023	2023	1.0	low	0	0	0	0	0	1
nelfinavir mesylate	0	methanesulfonate salt	antineoplastic agent; HIV protease inhibitor	0	0		low	0	0	0	0	0	0
nelfinavir	0	aryl sulfide; benzamides; organic heterobicyclic compound; phenols; secondary alcohol; tertiary amino compound	antineoplastic agent; HIV protease inhibitor	0	0		low	0	0	0	0	0	0
betulinic acid	5	hydroxy monocarboxylic acid; pentacyclic triterpenoid	anti-HIV agent; anti-inflammatory agent; antimalarial; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; plant metabolite	2010	2021	8.2	low	0	0	0	1	2	2
baicalin	0	dihydroxyflavone; glucosiduronic acid; glycosyloxyflavone; monosaccharide derivative	antiatherosclerotic agent; antibacterial agent; anticoronaviral agent; antineoplastic agent; antioxidant; cardioprotective agent; EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; ferroptosis inhibitor; neuroprotective agent; non-steroidal anti-inflammatory drug; plant metabolite; prodrug	0	0		low	0	0	0	0	0	0
ro 5-3335	0	1,4-benzodiazepinone; organochlorine compound; pyrroles	anti-HIV-1 agent; antineoplastic agent; HIV-1 Tat inhibitor; RUNX1 inhibitor	0	0		low	0	0	0	0	0	0
plerixafor	0	azacycloalkane; azamacrocycle; benzenes; crown amine; secondary amino compound; tertiary amino compound	anti-HIV agent; antineoplastic agent; C-X-C chemokine receptor type 4 antagonist; immunological adjuvant	0	0		low	0	0	0	0	0	0
epigallocatechin gallate	0	flavans; gallate ester; polyphenol	antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite	0	0		low	0	0	0	0	0	0
salvin	0	abietane diterpenoid; carbotricyclic compound; catechols; monocarboxylic acid	angiogenesis modulating agent; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; food preservative; HIV protease inhibitor; plant metabolite	0	0		low	0	0	0	0	0	0
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose	0	gallate ester; galloyl beta-D-glucose	anti-inflammatory agent; antineoplastic agent; geroprotector; hepatoprotective agent; plant metabolite; radiation protective agent; radical scavenger	0	0		low	0	0	0	0	0	0
pyrrolidine dithiocarbamate	0	dithiocarbamic acids; pyrrolidines	anticonvulsant; antineoplastic agent; geroprotector; neuroprotective agent; NF-kappaB inhibitor; radical scavenger	0	0		low	0	0	0	0	0	0
triptonide	0	butenolide; cyclic ketone; diterpene triepoxide; organic heteroheptacyclic compound	anti-inflammatory agent; antineoplastic agent; immunosuppressive agent	0	0		low	0	0	0	0	0	0
3'-deoxyadenosine 5'-triphosphate	0	purine ribonucleoside 5'-triphosphate	antifungal agent; antimetabolite; antineoplastic agent; antiviral agent	0	0		low	0	0	0	0	0	0
2-methoxyestradiol	0	17beta-hydroxy steroid; 3-hydroxy steroid	angiogenesis modulating agent; antimitotic; antineoplastic agent; human metabolite; metabolite; mouse metabolite	0	0		low	0	0	0	0	0	0
toxoflavin	0	carbonyl compound; pyrimidotriazine	antibacterial agent; antineoplastic agent; apoptosis inducer; bacterial metabolite; toxin; virulence factor; Wnt signalling inhibitor	0	0		low	0	0	0	0	0	0
lupulon	0	beta-bitter acid	angiogenesis inhibitor; antimicrobial agent; antineoplastic agent; apoptosis inducer	0	0		low	0	0	0	0	0	0
pinocembrin	0	(2S)-flavan-4-one; dihydroxyflavanone	antineoplastic agent; antioxidant; metabolite; neuroprotective agent; vasodilator agent	0	0		low	0	0	0	0	0	0
tangeretin	0	pentamethoxyflavone	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
ethinylestradiol-3-sulfate	0	17beta-hydroxy steroid; steroid sulfate	antineoplastic agent; estrogen	0	0		low	0	0	0	0	0	0
lonazolac	0	monocarboxylic acid; monochlorobenzenes; pyrazoles	antineoplastic agent; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug	0	0		low	0	0	0	0	0	0
bromopyruvate	0	2-oxo monocarboxylic acid; organobromine compound; oxo carboxylic acid	alkylating agent; antineoplastic agent	0	0		low	0	0	0	0	0	0
enrofloxacin	2	cyclopropanes; N-alkylpiperazine; N-arylpiperazine; organofluorine compound; quinolinemonocarboxylic acid; quinolone	antibacterial agent; antimicrobial agent; antineoplastic agent	1997	2017	17.0	low	0	0	1	0	1	0
dexrazoxane	0	razoxane	antineoplastic agent; cardiovascular drug; chelator; immunosuppressive agent	0	0		low	0	0	0	0	0	0
masoprocol	9	nordihydroguaiaretic acid	antineoplastic agent; hypoglycemic agent; lipoxygenase inhibitor; metabolite	1987	2013	28.0	low	0	1	6	1	1	0
dw a 2114r	0	platinum coordination entity; pyrrolidines	antineoplastic agent	0	0		low	0	0	0	0	0	0
prednisolone phosphate	0	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 3-oxo-Delta(1),Delta(4)-steroid; glucocorticoid; steroid phosphate; tertiary alpha-hydroxy ketone	anti-inflammatory agent; antineoplastic agent; glucocorticoid receptor agonist; prodrug	0	0		low	0	0	0	0	0	0
hesperetin	0	3'-hydroxyflavanones; 4'-methoxyflavanones; monomethoxyflavanone; trihydroxyflavanone	antineoplastic agent; antioxidant; plant metabolite	0	0		low	0	0	0	0	0	0
sesamin	0	benzodioxoles; furofuran; lignan	antineoplastic agent; neuroprotective agent; plant metabolite	0	0		low	0	0	0	0	0	0
betulin	0	diol; pentacyclic triterpenoid	analgesic; anti-inflammatory agent; antineoplastic agent; antiviral agent; metabolite	0	0		low	0	0	0	0	0	0
nobiletin	0	methoxyflavone	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
picropodophyllin	0	furonaphthodioxole; lignan; organic heterotetracyclic compound	antineoplastic agent; insulin-like growth factor receptor 1 antagonist; plant metabolite; tyrosine kinase inhibitor	0	0		low	0	0	0	0	0	0
alantolactone	0	naphthofuran; olefinic compound; sesquiterpene lactone	antineoplastic agent; apoptosis inducer; plant metabolite	0	0		low	0	0	0	0	0	0
kaurenoic acid	0	ent-kaurane diterpenoid	anti-HIV-1 agent; antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
dehydrocostus lactone	0	gamma-lactone; guaiane sesquiterpenoid; organic heterotricyclic compound; sesquiterpene lactone	antimycobacterial drug; antineoplastic agent; apoptosis inducer; cyclooxygenase 2 inhibitor; metabolite; trypanocidal drug	0	0		low	0	0	0	0	0	0
xanthomicrol	0	dihydroxyflavone; trimethoxyflavone	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
voacamine	0	alkaloid ester; methyl ester; monoterpenoid indole alkaloid; organic heteropentacyclic compound; tertiary amino compound	angiogenesis inhibitor; antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
brazilin	0	catechols; organic heterotetracyclic compound; tertiary alcohol	anti-inflammatory agent; antibacterial agent; antineoplastic agent; antioxidant; apoptosis inducer; biological pigment; hepatoprotective agent; histological dye; NF-kappaB inhibitor; plant metabolite	0	0		low	0	0	0	0	0	0
uvaretin	0	aromatic ether; dihydrochalcones; polyketide; resorcinol	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
fangchinoline	0	aromatic ether; bisbenzylisoquinoline alkaloid; macrocycle	anti-HIV-1 agent; anti-inflammatory agent; antineoplastic agent; antioxidant; neuroprotective agent; plant metabolite	0	0		low	0	0	0	0	0	0
maslinic acid	0	dihydroxy monocarboxylic acid; pentacyclic triterpenoid	anti-inflammatory agent; antineoplastic agent; antioxidant; plant metabolite	0	0		low	0	0	0	0	0	0
tetrazolium violet	0	organic chloride salt	antineoplastic agent; apoptosis inducer; dye	0	0		low	0	0	0	0	0	0
irinotecan hydrochloride	0	hydrochloride	antineoplastic agent; apoptosis inducer; EC 5.99.1.2 (DNA topoisomerase) inhibitor; prodrug	0	0		low	0	0	0	0	0	0
5-(3-methyl-1-triazeno)imidazole-4-carboxamide	0	imidazoles; monocarboxylic acid amide; triazene derivative	alkylating agent; antineoplastic agent	0	0		low	0	0	0	0	0	0
hydroxyguanidine	0	guanidines; one-carbon compound	antineoplastic agent; antiviral agent	0	0		low	0	0	0	0	0	0
cryptolepine	0	indole alkaloid; organic heterotetracyclic compound; organonitrogen heterocyclic compound	anti-inflammatory agent; antimalarial; antineoplastic agent; cysteine protease inhibitor; plant metabolite	0	0		low	0	0	0	0	0	0
bexarotene	0	benzoic acids; naphthalenes; retinoid	antineoplastic agent	0	0		low	0	0	0	0	0	0
3,4-dihydroxyphenylethanol	0	catechols; primary alcohol	antineoplastic agent; antioxidant; metabolite	0	0		low	0	0	0	0	0	0
terreic acid	0	arene epoxide; diketone; monohydroxy-1,4-benzoquinones; tertiary alpha-hydroxy ketone	antibacterial agent; antineoplastic agent; Aspergillus metabolite; EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor; EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; mycotoxin	0	0		low	0	0	0	0	0	0
4-methylumbelliferyl glucuronide	0	beta-D-glucosiduronic acid; coumarins; monosaccharide derivative	antineoplastic agent; chromogenic compound; hyaluronan synthesis inhibitor	0	0		low	0	0	0	0	0	0
9-hydroxyellipticine	0	organic heterotetracyclic compound; organonitrogen heterocyclic compound	antineoplastic agent	0	0		low	0	0	0	0	0	0
nimustine	0	hydrochloride	antineoplastic agent	0	0		low	0	0	0	0	0	0
beta-peltatin	0	furonaphthodioxole; gamma-lactone; lignan; organic heterotetracyclic compound; phenols	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
alpha-peltatin	0	furonaphthodioxole; gamma-lactone; lignan; organic heterotetracyclic compound; phenols	antineoplastic agent; metabolite	0	0		low	0	0	0	0	0	0
cryptopleurine	0	alkaloid antibiotic; alkaloid; aromatic ether; organic heteropentacyclic compound	antineoplastic agent; antiviral agent; protein synthesis inhibitor	0	0		low	0	0	0	0	0	0
sugiol	0	abietane diterpenoid; carbotricyclic compound; cyclic terpene ketone; meroterpenoid; phenols	antineoplastic agent; antioxidant; antiviral agent; plant metabolite; radical scavenger	0	0		low	0	0	0	0	0	0
eupatorin	0	dihydroxyflavone; polyphenol; trimethoxyflavone	anti-inflammatory agent; antineoplastic agent; apoptosis inducer; Brassica napus metabolite; calcium channel blocker; P450 inhibitor; vasodilator agent	0	0		low	0	0	0	0	0	0
1-methyltryptophan	0	non-proteinogenic alpha-amino acid; tryptophan derivative	antineoplastic agent; EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor	0	0		low	0	0	0	0	0	0
atromentin	0	dihydroxy-1,4-benzoquinones; polyphenol	antibacterial agent; anticoagulant; antineoplastic agent; apoptosis inducer; biological pigment; EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor; fungal metabolite	0	0		low	0	0	0	0	0	0
diosgenin	4	3beta-sterol; hexacyclic triterpenoid; sapogenin; spiroketal	antineoplastic agent; antiviral agent; apoptosis inducer; metabolite	2014	2018	7.2	low	0	0	0	0	4	0
alpha-glutamyltryptophan	0	dipeptide	angiogenesis modulating agent; antineoplastic agent; immunomodulator; metabolite	0	0		low	0	0	0	0	0	0
fulvestrant	8	17beta-hydroxy steroid; 3-hydroxy steroid; organofluorine compound; sulfoxide	antineoplastic agent; estrogen antagonist; estrogen receptor antagonist	1996	2014	18.4	low	0	0	1	6	1	0
ici 164384	0	17beta-hydroxy steroid; 3-hydroxy steroid; tertiary carboxamide	anti-estrogen; antineoplastic agent; estrogen receptor antagonist	0	0		low	0	0	0	0	0	0
sn 38	0	delta-lactone; phenols; pyranoindolizinoquinoline; tertiary alcohol	antineoplastic agent; apoptosis inducer; drug metabolite; EC 5.99.1.2 (DNA topoisomerase) inhibitor	0	0		low	0	0	0	0	0	0
deguelin	0	aromatic ether; diether; organic heteropentacyclic compound; rotenones	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; antiviral agent; apoptosis inducer; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; mitochondrial NADH:ubiquinone reductase inhibitor; plant metabolite	0	0		low	0	0	0	0	0	0
fingolimod	0	aminodiol; primary amino compound	antineoplastic agent; CB1 receptor antagonist; immunosuppressive agent; prodrug; sphingosine-1-phosphate receptor agonist	0	0		low	0	0	0	0	0	0
cafestol	0	diterpenoid; furans; organic heteropentacyclic compound; primary alcohol; tertiary alcohol	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; hypoglycemic agent; plant metabolite	0	0		low	0	0	0	0	0	0
tamibarotene	0	dicarboxylic acid monoamide; retinoid; tetralins	antineoplastic agent; retinoic acid receptor alpha/beta agonist	0	0		low	0	0	0	0	0	0
ecteinascidin 743	0	acetate ester; azaspiro compound; bridged compound; hemiaminal; isoquinoline alkaloid; lactone; organic heteropolycyclic compound; organic sulfide; oxaspiro compound; polyphenol; tertiary amino compound	alkylating agent; angiogenesis modulating agent; anti-inflammatory agent; antineoplastic agent; marine metabolite	0	0		low	0	0	0	0	0	0
homoorientin	0	flavone C-glycoside; tetrahydroxyflavone	antineoplastic agent; radical scavenger	0	0		low	0	0	0	0	0	0
kahweol	0	diterpenoid; furans; organic heteropentacyclic compound; primary alcohol; tertiary alcohol	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; plant metabolite	0	0		low	0	0	0	0	0	0
selenomethylselenocysteine	0	non-proteinogenic alpha-amino acid; selenocysteines	antineoplastic agent; human metabolite	0	0		low	0	0	0	0	0	0
tephrosin	0	aromatic ether; cyclic ketone; organic heteropentacyclic compound; rotenones	antineoplastic agent; metabolite; pesticide	0	0		low	0	0	0	0	0	0
5-(tetradecyloxy)-2-furancarboxylic acid	0	aromatic ether; furoic acid	antineoplastic agent; apoptosis inducer; EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor; PPARalpha agonist	0	0		low	0	0	0	0	0	0
sc 58125	0	organofluorine compound; pyrazoles; sulfone	antineoplastic agent; cyclooxygenase 2 inhibitor	0	0		low	0	0	0	0	0	0
marimastat	0	hydroxamic acid; secondary carboxamide	antineoplastic agent; matrix metalloproteinase inhibitor	0	0		low	0	0	0	0	0	0
1'-acetoxychavicol acetate	0	acetate ester; phenylpropanoid	antineoplastic agent; NF-kappaB inhibitor; plant metabolite	0	0		low	0	0	0	0	0	0
clofarabine	0	adenosines; organofluorine compound	antimetabolite; antineoplastic agent	0	0		low	0	0	0	0	0	0
dioscin	0	hexacyclic triterpenoid; spiroketal; spirostanyl glycoside; trisaccharide derivative	anti-inflammatory agent; antifungal agent; antineoplastic agent; antiviral agent; apoptosis inducer; EC 1.14.18.1 (tyrosinase) inhibitor; hepatoprotective agent; metabolite	0	0		low	0	0	0	0	0	0
ginsenoside rh2	0	12beta-hydroxy steroid; 20-hydroxy steroid; beta-D-glucoside; ginsenoside; tetracyclic triterpenoid	antineoplastic agent; apoptosis inducer; bone density conservation agent; cardioprotective agent; hepatoprotective agent; plant metabolite	0	0		low	0	0	0	0	0	0
celastrol	0	monocarboxylic acid; pentacyclic triterpenoid	anti-inflammatory drug; antineoplastic agent; antioxidant; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Hsp90 inhibitor; metabolite	0	0		low	0	0	0	0	0	0
4'-demethylepipodophyllotoxin	0	furonaphthodioxole; organic heterotetracyclic compound; phenols	antineoplastic agent	0	0		low	0	0	0	0	0	0
imatinib mesylate	1	methanesulfonate salt	anticoronaviral agent; antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor	2015	2015	9.0	low	0	0	0	0	1	0
aminolevulinic acid hydrochloride	0	hydrochloride	antineoplastic agent; dermatologic drug; photosensitizing agent; prodrug	0	0		low	0	0	0	0	0	0
gefitinib	0	aromatic ether; monochlorobenzenes; monofluorobenzenes; morpholines; quinazolines; secondary amino compound; tertiary amino compound	antineoplastic agent; epidermal growth factor receptor antagonist	0	0		low	0	0	0	0	0	0
cgp 42112a	0	benzyl ester; oligopeptide; pyridinecarboxamide	angiotensin receptor agonist; anti-inflammatory agent; antineoplastic agent; neuroprotective agent; vasodilator agent	0	0		low	0	0	0	0	0	0
vadimezan	0	monocarboxylic acid; xanthones	antineoplastic agent	0	0		low	0	0	0	0	0	0
rubimaillin	0	benzochromene; methyl ester; phenols	acyl-CoA:cholesterol acyltransferase 2 inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; neuroprotective agent; NF-kappaB inhibitor; plant metabolite	0	0		low	0	0	0	0	0	0
4-carbamoylimidazolium 5-olate	0	hydroxyimidazole; monocarboxylic acid amide	antineoplastic agent	0	0		low	0	0	0	0	0	0
nsc 224070	0	1,4-benzoquinones; aziridines; enamine; primary alcohol; secondary amino compound	alkylating agent; antineoplastic agent	0	0		low	0	0	0	0	0	0
psorospermin	0	epoxide; organic heterotetracyclic compound; xanthones	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
ay 25545	0	acetate ester; aromatic ether; C-glycosyl compound; naphthoisochromene; olefinic compound; phenols; tertiary amine	antimicrobial agent; antineoplastic agent; bacterial metabolite	0	0		low	0	0	0	0	0	0
methotrexate	52	dicarboxylic acid; monocarboxylic acid amide; pteridines	abortifacient; antimetabolite; antineoplastic agent; antirheumatic drug; dermatologic drug; DNA synthesis inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; immunosuppressive agent	1992	2021	15.1	low	1	0	10	17	23	2
3,7-dihydroxytropolone	0	alpha-hydroxy ketone; cyclic ketone; enol; triol	antineoplastic agent; bacterial metabolite	0	0		low	0	0	0	0	0	0
delphinidin	0	5-hydroxyanthocyanidin	antineoplastic agent; biological pigment; plant metabolite	0	0		low	0	0	0	0	0	0
tamsulosin	0	5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide	alpha-adrenergic antagonist; antineoplastic agent	0	0		low	0	0	0	0	0	0
saintopin	0	tetracenequinones	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; fungal metabolite; intercalator	0	0		low	0	0	0	0	0	0
6-bromo-3-(bromomethyl)-7-methyl-2,3,7-trichloro-1-octene	0	monoterpenoid; organobromine compound; organochlorine compound	algal metabolite; antineoplastic agent; marine metabolite	0	0		low	0	0	0	0	0	0
ilomastat	0	hydroxamic acid; L-tryptophan derivative; N-acyl-amino acid	anti-inflammatory agent; antibacterial agent; antineoplastic agent; EC 3.4.24.24 (gelatinase A) inhibitor; neuroprotective agent	0	0		low	0	0	0	0	0	0
abiraterone	0	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; pyridines	antineoplastic agent; EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor	0	0		low	0	0	0	0	0	0
yakuchinone-a	0	ketone; monomethoxybenzene; phenols	antineoplastic agent; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; EC 1.14.13.39 (nitric oxide synthase) inhibitor; metabolite	0	0		low	0	0	0	0	0	0
pomalidomide	0	aromatic amine; dicarboximide; isoindoles; piperidones	angiogenesis inhibitor; antineoplastic agent; immunomodulator	0	0		low	0	0	0	0	0	0
tempol	0	aminoxyls; hydroxypiperidine	anti-inflammatory agent; antineoplastic agent; apoptosis inducer; catalyst; hepatoprotective agent; nephroprotective agent; neuroprotective agent; radical scavenger	0	0		low	0	0	0	0	0	0
selenomethylselenocysteine	0	amino acid zwitterion; L-selenocysteine derivative; non-proteinogenic L-alpha-amino acid; Se-methylselenocysteine	antineoplastic agent	0	0		low	0	0	0	0	0	0
10-propargyl-10-deazaaminopterin	0	N-acyl-L-glutamic acid; pteridines; terminal acetylenic compound	antimetabolite; antineoplastic agent; EC 1.5.1.3 (dihydrofolate reductase) inhibitor	0	0		low	0	0	0	0	0	0
docetaxel	0	hydrate; secondary alpha-hydroxy ketone	antineoplastic agent	0	0		low	0	0	0	0	0	0
docetaxel anhydrous	1	secondary alpha-hydroxy ketone; tetracyclic diterpenoid	antimalarial; antineoplastic agent; photosensitizing agent	2018	2018	6.0	low	0	0	0	0	1	0
lonafarnib	0	4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide	antineoplastic agent; EC 2.5.1.58 (protein farnesyltransferase) inhibitor	0	0		low	0	0	0	0	0	0
aclacinomycin	0	aminoglycoside; anthracycline; deoxy hexoside; methyl ester; monosaccharide derivative; phenols; polyketide; tertiary alcohol; tetracenequinones; zwitterion	antimicrobial agent; antineoplastic agent; metabolite	0	0		low	0	0	0	0	0	0
6-azauridine-5'-monophosphate	0	N-glycosyl-1,2,4-triazine; nucleoside monophosphate analogue	antineoplastic agent; EC 4.1.1.23 (orotidine-5'-phosphate decarboxylase) inhibitor	0	0		low	0	0	0	0	0	0
ptk 787	0	succinate salt	angiogenesis inhibitor; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; vascular endothelial growth factor receptor antagonist	0	0		low	0	0	0	0	0	0
vatalanib	0	monochlorobenzenes; phthalazines; pyridines; secondary amino compound	angiogenesis inhibitor; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; vascular endothelial growth factor receptor antagonist	0	0		low	0	0	0	0	0	0
cyc 682	0	nitrile; nucleoside analogue; secondary carboxamide	antimetabolite; antineoplastic agent; DNA synthesis inhibitor; prodrug	0	0		low	0	0	0	0	0	0
canertinib	0	monochlorobenzenes; morpholines; organofluorine compound; quinazolines	antineoplastic agent; tyrosine kinase inhibitor	0	0		low	0	0	0	0	0	0
methyl 5-aminolevulinate hydrochloride	0	hydrochloride	antineoplastic agent; dermatologic drug; photosensitizing agent; prodrug	0	0		low	0	0	0	0	0	0
methyl 5-aminolevulinate	0	delta-amino acid ester	antineoplastic agent; dermatologic drug; photosensitizing agent; prodrug	0	0		low	0	0	0	0	0	0
tipifarnib	0	imidazoles; monochlorobenzenes; primary amino compound; quinolone	antineoplastic agent; apoptosis inducer; EC 2.5.1.58 (protein farnesyltransferase) inhibitor	0	0		low	0	0	0	0	0	0
aklavinone	0	anthracycline; methyl ester; tertiary alcohol; tetracenequinones	antineoplastic agent	0	0		low	0	0	0	0	0	0
actinodaphine	0	aporphine alkaloid; aromatic ether; organic heteropentacyclic compound; phenols; secondary amino compound	antibacterial agent; antifungal agent; antineoplastic agent; apoptosis inducer; plant metabolite; platelet aggregation inhibitor; topoisomerase inhibitor	0	0		low	0	0	0	0	0	0
i-677	0	L-serine derivative; non-proteinogenic L-alpha-amino acid	antimetabolite; antimicrobial agent; antineoplastic agent; metabolite	0	0		low	0	0	0	0	0	0
anonaine	0	aporphine alkaloid; organic heteropentacyclic compound; oxacycle	antineoplastic agent; antiplasmodial drug; trypanocidal drug	0	0		low	0	0	0	0	0	0
4'-demethyldesoxypodophyllotoxin	0	furonaphthodioxole; gamma-lactone; lignan; methoxybenzenes; phenols	antineoplastic agent; antioxidant; immunosuppressive agent; plant metabolite	0	0		low	0	0	0	0	0	0
salvigenin	0	monohydroxyflavone; trimethoxyflavone	antilipemic drug; antineoplastic agent; apoptosis inhibitor; autophagy inducer; hypoglycemic agent; immunomodulator; neuroprotective agent; plant metabolite	0	0		low	0	0	0	0	0	0
deferrioxamine e	0	cyclic desferrioxamine; cyclic hydroxamic acid; macrocycle	antineoplastic agent; bacterial metabolite; marine metabolite; siderophore	0	0		low	0	0	0	0	0	0
ampelopsin	0	dihydromyricetin; secondary alpha-hydroxy ketone	antineoplastic agent; antioxidant; metabolite	0	0		low	0	0	0	0	0	0
acetyl aleuritolic acid	0	acetate ester; monocarboxylic acid; pentacyclic triterpenoid	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
withanolide d	0	20-hydroxy steroid; 4-hydroxy steroid; delta-lactone; enone; epoxy steroid; ergostanoid; secondary alcohol; tertiary alcohol; withanolide	antineoplastic agent	0	0		low	0	0	0	0	0	0
myricanone	0	aromatic ether; cyclic ketone; diarylheptanoid; methoxybenzenes; phenols	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
cirsilineol	0	dihydroxyflavone; trimethoxyflavone	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
pannarin	0	aldehyde; aromatic ether; depsidones; organic heterotricyclic compound; organochlorine compound; phenols	antimicrobial agent; antineoplastic agent; apoptosis inducer; lichen metabolite	0	0		low	0	0	0	0	0	0
6-methylthiohexyl isothiocyanate	0	isothiocyanate; methyl sulfide	antineoplastic agent; Arabidopsis thaliana metabolite; EC 4.1.1.17 (ornithine decarboxylase) inhibitor; neuroprotective agent	0	0		low	0	0	0	0	0	0
pectolinarin	0	dimethoxyflavone; disaccharide derivative; glycosyloxyflavone; monohydroxyflavanone; rutinoside	anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; plant metabolite	0	0		low	0	0	0	0	0	0
albicanol	0	carbobicyclic compound; homoallylic alcohol; primary alcohol; sesquiterpenoid	antifeedant; antifungal agent; antineoplastic agent; fungal metabolite; mammalian metabolite; marine metabolite; plant metabolite	0	0		low	0	0	0	0	0	0
5-o-methylembelin	0	enol ether; monohydroxy-1,4-benzoquinones	antileishmanial agent; antineoplastic agent; hepatitis C protease inhibitor; metabolite	0	0		low	0	0	0	0	0	0
asperphenamate	0	benzamides; carboxylic ester; L-phenylalanine derivative	antineoplastic agent	0	0		low	0	0	0	0	0	0
erlotinib	0	aromatic ether; quinazolines; secondary amino compound; terminal acetylenic compound	antineoplastic agent; epidermal growth factor receptor antagonist; protein kinase inhibitor	0	0		low	0	0	0	0	0	0
erlotinib hydrochloride	1	hydrochloride; terminal acetylenic compound	antineoplastic agent; protein kinase inhibitor	2023	2023	1.0	low	1	0	0	0	0	1
corynoline	0	benzophenanthridine alkaloid; cyclic acetal; isoquinolines; organic heterohexacyclic compound; secondary alcohol	antineoplastic agent; EC 3.1.1.7 (acetylcholinesterase) inhibitor; hepatoprotective agent; metabolite	0	0		low	0	0	0	0	0	0
helioxanthin	0	benzodioxoles; furonaphthodioxole; lignan	anti-HBV agent; antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
top 53	0	furonaphthodioxole; gamma-lactone; organic heterotetracyclic compound; phenols; tertiary amino compound	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor	0	0		low	0	0	0	0	0	0
5-heptadecylresorcinol	0	5-alkylresorcinol	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
minquartynoic acid	0	acetylenic fatty acid; hydroxy polyunsaturated fatty acid; long-chain fatty acid; straight-chain fatty acid; tetrayne	antimalarial; antineoplastic agent; antiviral agent	0	0		low	0	0	0	0	0	0
scutellarin	0	glucosiduronic acid; glycosyloxyflavone; monosaccharide derivative; trihydroxyflavone	antineoplastic agent; proteasome inhibitor	0	0		low	0	0	0	0	0	0
ergolide	0	acetate ester; cyclic ketone; gamma-lactone; organic heterotricyclic compound; sesquiterpene lactone	anti-inflammatory agent; antineoplastic agent; metabolite; NF-kappaB inhibitor; plant metabolite	0	0		low	0	0	0	0	0	0
2,5-dihydroxybenzyl alcohol	0	aromatic primary alcohol; phenols	antineoplastic agent; antioxidant; apoptosis inhibitor; fungal metabolite	0	0		low	0	0	0	0	0	0
chrysosplenol c	0	trihydroxyflavone; trimethoxyflavone	antineoplastic agent; antiviral agent; plant metabolite	0	0		low	0	0	0	0	0	0
lanperisone	0	2-methyl-3-(pyrrolidin-1-yl)-1-[4-(trifluoromethyl)phenyl]propan-1-one	antineoplastic agent; calcium channel blocker; ferroptosis inducer; muscle relaxant; voltage-gated sodium channel blocker	0	0		low	0	0	0	0	0	0
(-)-gallocatechin gallate	0	catechin; gallate ester; polyphenol	antineoplastic agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; human xenobiotic metabolite; plant metabolite	0	0		low	0	0	0	0	0	0
orantinib	0	monocarboxylic acid; oxindoles; pyrroles	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; vascular endothelial growth factor receptor antagonist	0	0		low	0	0	0	0	0	0
lapatinib	0	furans; organochlorine compound; organofluorine compound; quinazolines	antineoplastic agent; tyrosine kinase inhibitor	0	0		low	0	0	0	0	0	0
firocoxib	0	butenolide; cyclopropanes; enol ether; sulfone	antineoplastic agent; cyclooxygenase 2 inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug	0	0		low	0	0	0	0	0	0
2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0	morpholines; purines; secondary amino compound; tertiary amino compound	adenosine A3 receptor antagonist; antineoplastic agent; Aurora kinase inhibitor; cell dedifferentiation agent	0	0		low	0	0	0	0	0	0
sorafenib	1	(trifluoromethyl)benzenes; aromatic ether; monochlorobenzenes; phenylureas; pyridinecarboxamide	angiogenesis inhibitor; anticoronaviral agent; antineoplastic agent; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; ferroptosis inducer; tyrosine kinase inhibitor	2021	2021	3.0	low	0	0	0	0	0	1
lenalidomide	1	aromatic amine; dicarboximide; isoindoles; piperidones	angiogenesis inhibitor; antineoplastic agent; immunomodulator	2017	2017	7.0	low	0	0	0	0	1	0
lasofoxifene	0	aromatic ether; N-alkylpyrrolidine; naphthols; tetralins	antineoplastic agent; bone density conservation agent; cardioprotective agent; estrogen receptor agonist; estrogen receptor antagonist	0	0		low	0	0	0	0	0	0
l 778,123	0	hydrochloride	antineoplastic agent; EC 2.5.1.58 (protein farnesyltransferase) inhibitor; EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor; radiosensitizing agent	0	0		low	0	0	0	0	0	0
l 778,123	0	imidazoles; monochlorobenzenes; nitrile; piperazinone; tertiary amino compound	antineoplastic agent; EC 2.5.1.58 (protein farnesyltransferase) inhibitor; EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor	0	0		low	0	0	0	0	0	0
n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide	0	chloroindole; organochlorine compound; sulfonamide	antineoplastic agent; EC 4.2.1.1 (carbonic anhydrase) inhibitor	0	0		low	0	0	0	0	0	0
diflomotecan	0	epsilon-lactone; organic heteropentacyclic compound; organofluorine compound; organonitrogen heterocyclic compound; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor	0	0		low	0	0	0	0	0	0
demecolcine	1	alkaloid; secondary amino compound	antineoplastic agent; microtubule-destabilising agent	1990	1990	34.0	low	0	0	1	0	0	0
dromostanolone propionate	0	3-oxo-5alpha-steroid; steroid ester	antineoplastic agent	0	0		low	0	0	0	0	0	0
vincaleukoblastine	0	acetate ester; indole alkaloid fundamental parent; methyl ester; organic heteropentacyclic compound; organic heterotetracyclic compound; tertiary alcohol; tertiary amino compound; vinca alkaloid	antineoplastic agent; immunosuppressive agent; microtubule-destabilising agent; plant metabolite	0	0		low	0	0	0	0	0	0
vincristine sulfate	0	organic sulfate salt	antineoplastic agent; geroprotector	0	0		low	0	0	0	0	0	0
anisomycin	0	monohydroxypyrrolidine; organonitrogen heterocyclic antibiotic	anticoronaviral agent; antimicrobial agent; antineoplastic agent; antiparasitic agent; bacterial metabolite; DNA synthesis inhibitor; protein synthesis inhibitor	0	0		low	0	0	0	0	0	0
estramustine	0	17beta-hydroxy steroid; carbamate ester; organochlorine compound	alkylating agent; antineoplastic agent; radiation protective agent	0	0		low	0	0	0	0	0	0
withaferin a	0	27-hydroxy steroid; 4-hydroxy steroid; delta-lactone; enone; epoxy steroid; ergostanoid; primary alcohol; secondary alcohol; withanolide	antineoplastic agent; apoptosis inducer	0	0		low	0	0	0	0	0	0
noscapine	2	aromatic ether; benzylisoquinoline alkaloid; cyclic acetal; isobenzofuranone; organic heterobicyclic compound; organic heterotricyclic compound; tertiary amino compound	antineoplastic agent; antitussive; apoptosis inducer; plant metabolite	2021	2023	2.0	low	0	0	0	0	0	2
homoharringtonine	0	alkaloid ester; enol ether; organic heteropentacyclic compound; tertiary alcohol	anticoronaviral agent; antineoplastic agent; apoptosis inducer; protein synthesis inhibitor	0	0		low	0	0	0	0	0	0
acivicin	0	isoxazoles; non-proteinogenic L-alpha-amino acid; organochlorine compound	antileishmanial agent; antimetabolite; antimicrobial agent; antineoplastic agent; EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor; glutamine antagonist; metabolite	0	0		low	0	0	0	0	0	0
elesclomol	0	carbohydrazide; thiocarbonyl compound	antineoplastic agent; apoptosis inducer	0	0		low	0	0	0	0	0	0
wortmannin	20	acetate ester; cyclic ketone; delta-lactone; organic heteropentacyclic compound	anticoronaviral agent; antineoplastic agent; autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector; Penicillium metabolite; radiosensitizing agent	1997	2021	14.5	low	0	0	1	10	8	1
rocaglamide	0	monocarboxylic acid amide; monomethoxybenzene; organic heterotricyclic compound	antileishmanial agent; antineoplastic agent; metabolite	0	0		low	0	0	0	0	0	0
anthricin	0	furonaphthodioxole; gamma-lactone; lignan; methoxybenzenes	antineoplastic agent; apoptosis inducer; plant metabolite	0	0		low	0	0	0	0	0	0
acronine	0	acridone derivatives; alkaloid	antineoplastic agent; metabolite	0	0		low	0	0	0	0	0	0
taiwanin c	0	benzodioxoles; furonaphthodioxole; lignan	antineoplastic agent; plant metabolite; platelet aggregation inhibitor	0	0		low	0	0	0	0	0	0
o-(chloroacetylcarbamoyl)fumagillol	0	carbamate ester; organochlorine compound; semisynthetic derivative; sesquiterpenoid; spiro-epoxide	angiogenesis inhibitor; antineoplastic agent; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; methionine aminopeptidase 2 inhibitor; retinoic acid receptor alpha antagonist	0	0		low	0	0	0	0	0	0
bortezomib	1	amino acid amide; L-phenylalanine derivative; pyrazines	antineoplastic agent; antiprotozoal drug; protease inhibitor; proteasome inhibitor	2011	2011	13.0	low	0	0	0	0	1	0
gant 61	0	aminal; dialkylarylamine; pyridines; substituted aniline; tertiary amino compound	antineoplastic agent; apoptosis inducer; glioma-associated oncogene inhibitor; Hedgehog signaling pathway inhibitor	0	0		low	0	0	0	0	0	0
carnosine	7	amino acid zwitterion; dipeptide	anticonvulsant; antineoplastic agent; antioxidant; Daphnia magna metabolite; geroprotector; human metabolite; mouse metabolite; neuroprotective agent	1990	2017	23.6	low	0	0	4	2	1	0
puromycin	1	puromycins	antiinfective agent; antimicrobial agent; antineoplastic agent; EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor; EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor; nucleoside antibiotic; protein synthesis inhibitor	1978	1978	46.0	low	0	1	0	0	0	0
pentostatin	1	coformycins	antimetabolite; antineoplastic agent; Aspergillus metabolite; bacterial metabolite; EC 3.5.4.4 (adenosine deaminase) inhibitor	1994	1994	30.0	low	0	0	1	0	0	0
canaline	0	amino acid zwitterion; non-proteinogenic L-alpha-amino acid	antimetabolite; antineoplastic agent; phytogenic insecticide; plant metabolite	0	0		low	0	0	0	0	0	0
hippeastrine	0	delta-lactone; indole alkaloid; organic heteropentacyclic compound; secondary alcohol	antineoplastic agent; metabolite	0	0		low	0	0	0	0	0	0
peonidin	0	5-hydroxyanthocyanidin	antineoplastic agent; antioxidant; apoptosis inducer; metabolite	0	0		low	0	0	0	0	0	0
glaucarubinone	0	carboxylic ester; organic heteropentacyclic compound; quassinoid; secondary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone; tetrol	antimalarial; antineoplastic agent; geroprotector; plant metabolite	0	0		low	0	0	0	0	0	0
helveticoside	0	14beta-hydroxy steroid; 5beta-hydroxy steroid; cardenolide glycoside; digitoxoside; monosaccharide derivative; steroid aldehyde; steroid lactone	antineoplastic agent; apoptosis inducer; plant metabolite	0	0		low	0	0	0	0	0	0
ginsenoside re	0	12beta-hydroxy steroid; 3beta-hydroxy-4,4-dimethylsteroid; 3beta-hydroxy steroid; beta-D-glucoside; disaccharide derivative; ginsenoside; tetracyclic triterpenoid	anti-inflammatory agent; antineoplastic agent; antioxidant; nephroprotective agent; neuroprotective agent; plant metabolite	0	0		low	0	0	0	0	0	0
ginsenoside rf	0	12beta-hydroxy steroid; 20-hydroxy steroid; 3beta-hydroxy-4,4-dimethylsteroid; 3beta-hydroxy steroid; beta-D-glucoside; disaccharide derivative; ginsenoside; tetracyclic triterpenoid	antineoplastic agent; apoptosis inducer; plant metabolite	0	0		low	0	0	0	0	0	0
ferruginol	0	abietane diterpenoid; carbotricyclic compound; meroterpenoid; phenols	antibacterial agent; antineoplastic agent; plant metabolite; protective agent	0	0		low	0	0	0	0	0	0
stevioside	0	beta-D-glucoside; bridged compound; diterpene glycoside; ent-kaurane diterpenoid; tetracyclic diterpenoid	anti-inflammatory agent; antineoplastic agent; antioxidant; hypoglycemic agent; plant metabolite; sweetening agent	0	0		low	0	0	0	0	0	0
decursinol	0	cyclic ether; delta-lactone; organic heterotricyclic compound; secondary alcohol	analgesic; antineoplastic agent; EC 3.1.1.7 (acetylcholinesterase) inhibitor; metabolite	0	0		low	0	0	0	0	0	0
naringin	0	(2S)-flavan-4-one; 4'-hydroxyflavanones; dihydroxyflavanone; disaccharide derivative; neohesperidoside	anti-inflammatory agent; antineoplastic agent; metabolite	0	0		low	0	0	0	0	0	0
eugeniin	0	beta-D-glucoside; ellagitannin; gallate ester; lactone	anti-HSV-1 agent; antifungal agent; antineoplastic agent; EC 3.2.1.20 (alpha-glucosidase) inhibitor; metabolite	0	0		low	0	0	0	0	0	0
knipholone	0	aromatic ketone; dihydroxyanthraquinone; methoxybenzenes; methyl ketone; polyphenol; resorcinols	antineoplastic agent; antioxidant; antiplasmodial drug; leukotriene antagonist; metabolite	0	0		low	0	0	0	0	0	0
gingerol	0	beta-hydroxy ketone; guaiacols	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
mucronulatol	0	hydroxyisoflavans; methoxyisoflavan	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
syringaresinol	0	syringaresinol	antineoplastic agent	0	0		low	0	0	0	0	0	0
enkephalin, methionine	0	pentapeptide; peptide zwitterion	analgesic; antineoplastic agent; delta-opioid receptor agonist; human metabolite; mu-opioid receptor agonist	0	0		low	0	0	0	0	0	0
devazepide	0	1,4-benzodiazepinone; indolecarboxamide	antineoplastic agent; apoptosis inducer; cholecystokinin antagonist; gastrointestinal drug	0	0		low	0	0	0	0	0	0
sodium arsenite	0	arsenic molecular entity; inorganic sodium salt	antibacterial agent; antifungal agent; antineoplastic agent; carcinogenic agent; herbicide; insecticide; rodenticide	0	0		low	0	0	0	0	0	0
surfactin c	0	cyclodepsipeptide; lipopeptide antibiotic; macrocyclic lactone	antibacterial agent; antifungal agent; antineoplastic agent; antiviral agent; metabolite; platelet aggregation inhibitor; surfactant	0	0		low	0	0	0	0	0	0
kerriamycin b	0	angucycline antibiotic	antineoplastic agent	0	0		low	0	0	0	0	0	0
carubicin	0	aminoglycoside antibiotic; anthracycline antibiotic; p-quinones; tertiary alpha-hydroxy ketone; tetracenequinones	antineoplastic agent; apoptosis inducer	0	0		low	0	0	0	0	0	0
tretinoin	31	retinoic acid; vitamin A	anti-inflammatory agent; antineoplastic agent; antioxidant; AP-1 antagonist; human metabolite; keratolytic drug; retinoic acid receptor agonist; retinoid X receptor agonist; signalling molecule	1984	2023	24.4	low	0	4	16	6	4	1
docosahexaenoate	0	docosahexaenoic acid; omega-3 fatty acid	algal metabolite; antineoplastic agent; Daphnia tenebrosa metabolite; human metabolite; mouse metabolite; nutraceutical	0	0		low	0	0	0	0	0	0
eicosapentaenoic acid	11	icosapentaenoic acid; omega-3 fatty acid	anticholesteremic drug; antidepressant; antineoplastic agent; Daphnia galeata metabolite; fungal metabolite; micronutrient; mouse metabolite; nutraceutical	1993	2018	16.7	low	2	0	3	4	4	0
mycophenolic acid	14	2-benzofurans; gamma-lactone; monocarboxylic acid; phenols	anticoronaviral agent; antimicrobial agent; antineoplastic agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; environmental contaminant; immunosuppressive agent; mycotoxin; Penicillium metabolite; xenobiotic	2005	2022	11.3	low	1	0	0	6	6	2
formycin	0	formycin	antineoplastic agent	0	0		low	0	0	0	0	0	0
neocarzinostatin chromophore	0	cyclopentacyclononaoxirene; D-galactosaminide; dioxolane; monosaccharide derivative; naphthoate ester	antineoplastic agent	0	0		low	0	0	0	0	0	0
epothilone b	0	epothilone; epoxide	antineoplastic agent; apoptosis inducer; microtubule-stabilising agent	0	0		low	0	0	0	0	0	0
adenosine-5'-(n-ethylcarboxamide)	3	adenosines; monocarboxylic acid amide	adenosine A1 receptor agonist; adenosine A2A receptor agonist; antineoplastic agent; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; vasodilator agent	1996	2010	20.7	low	0	0	1	2	0	0
n(1)-guanyl-1,7-diaminoheptane	0	guanidines; primary amino compound	antineoplastic agent; EC 2.5.1.46 (deoxyhypusine synthase) inhibitor	0	0		low	0	0	0	0	0	0
diethylstilbestrol	12	olefinic compound; polyphenol	antifungal agent; antineoplastic agent; autophagy inducer; calcium channel blocker; carcinogenic agent; EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor; endocrine disruptor; xenoestrogen	1955	2021	32.0	low	0	4	3	4	0	1
bms 214662	0	benzenes; benzodiazepine; imidazoles; nitrile; sulfonamide; thiophenes	antineoplastic agent; apoptosis inducer; EC 2.5.1.58 (protein farnesyltransferase) inhibitor	0	0		low	0	0	0	0	0	0
epothilone a	0	epothilone; epoxide	antineoplastic agent; metabolite; microtubule-stabilising agent; tubulin modulator	0	0		low	0	0	0	0	0	0
8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pent-4-yn-1-yl-9H-purin-6-amine	0	6-aminopurines; acetylenic compound; methoxybenzenes; monochlorobenzenes; organofluorine compound	antineoplastic agent; Hsp90 inhibitor	0	0		low	0	0	0	0	0	0
alitretinoin	0	retinoic acid	antineoplastic agent; keratolytic drug; metabolite; retinoid X receptor agonist	0	0		low	0	0	0	0	0	0
afimoxifene	0	phenols; tertiary amino compound	antineoplastic agent; estrogen receptor antagonist; metabolite	0	0		low	0	0	0	0	0	0
aclarubicin	0	aminoglycoside; anthracycline; methyl ester; phenols; polyketide; tetracenequinones; trisaccharide derivative; zwitterion	antimicrobial agent; antineoplastic agent; apoptosis inducer; bacterial metabolite; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor	0	0		low	0	0	0	0	0	0
teniposide	0	aromatic ether; beta-D-glucoside; cyclic acetal; furonaphthodioxole; gamma-lactone; monosaccharide derivative; phenols; thiophenes	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor	0	0		low	0	0	0	0	0	0
steviol	0	bridged compound; ent-kaurane diterpenoid; monocarboxylic acid; tertiary allylic alcohol; tetracyclic diterpenoid	antineoplastic agent	0	0		low	0	0	0	0	0	0
tiazofurin	0	1,3-thiazoles; C-glycosyl compound; monocarboxylic acid amide	antineoplastic agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; prodrug	0	0		low	0	0	0	0	0	0
aphidicolin	0	tetracyclic diterpenoid	antimicrobial agent; antimitotic; antineoplastic agent; antiviral drug; apoptosis inducer; Aspergillus metabolite; DNA synthesis inhibitor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; fungal metabolite	0	0		low	0	0	0	0	0	0
azaserine	0	carboxylic ester; diazo compound; L-serine derivative; non-proteinogenic L-alpha-amino acid	antifungal agent; antimetabolite; antimicrobial agent; antineoplastic agent; glutamine antagonist; immunosuppressive agent; metabolite	0	0		low	0	0	0	0	0	0
melphalan	3	L-phenylalanine derivative; nitrogen mustard; non-proteinogenic L-alpha-amino acid; organochlorine compound	alkylating agent; antineoplastic agent; carcinogenic agent; drug allergen; immunosuppressive agent	1986	2018	21.7	low	0	1	0	1	1	0
prinomastat	0	aromatic ether; hydroxamic acid; pyridines; sulfonamide; thiomorpholines	antineoplastic agent; EC 3.4.24.35 (gelatinase B) inhibitor; matrix metalloproteinase inhibitor	0	0		low	0	0	0	0	0	0
rubitecan	0	C-nitro compound; delta-lactone; pyranoindolizinoquinoline; semisynthetic derivative; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; prodrug	0	0		low	0	0	0	0	0	0
arsenic trioxide	0	arsenic oxide	antineoplastic agent; insecticide	0	0		low	0	0	0	0	0	0
rhapontin	0	rhaponticin	angiogenesis inhibitor; anti-allergic agent; anti-inflammatory agent; antilipemic drug; antineoplastic agent; apoptosis inducer; EC 2.3.1.85 (fatty acid synthase) inhibitor; hypoglycemic agent; neuroprotective agent; plant metabolite	0	0		low	0	0	0	0	0	0
isoliquiritigenin	0	chalcones	antineoplastic agent; biological pigment; EC 1.14.18.1 (tyrosinase) inhibitor; GABA modulator; geroprotector; metabolite; NMDA receptor antagonist	0	0		low	0	0	0	0	0	0
antofine	0	alkaloid antibiotic; alkaloid; aromatic ether; organic heteropentacyclic compound	angiogenesis inhibitor; anti-inflammatory agent; antimicrobial agent; antineoplastic agent; antiviral agent; phytotoxin; plant metabolite	0	0		low	0	0	0	0	0	0
xanthohumol	0	aromatic ether; chalcones; polyphenol	anti-HIV-1 agent; antineoplastic agent; antiviral agent; apoptosis inducer; EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitor; metabolite	0	0		low	0	0	0	0	0	0
vedelianin	0	cyclic ether; organic heterotricyclic compound; resorcinols; stilbenoid	antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
s 1033	0	(trifluoromethyl)benzenes; imidazoles; pyridines; pyrimidines; secondary amino compound; secondary carboxamide	anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor	0	0		low	0	0	0	0	0	0
amygdalin	0	amygdalin	antineoplastic agent; apoptosis inducer; plant metabolite	0	0		low	0	0	0	0	0	0
trilostane	0	17beta-hydroxy steroid; 3-hydroxy steroid; androstanoid; epoxy steroid; nitrile	abortifacient; antineoplastic agent; EC 1.1.1.210 [3beta(or 20alpha)-hydroxysteroid dehydrogenase] inhibitor	0	0		low	0	0	0	0	0	0
leuprolide acetate	0	acetate salt	antineoplastic agent; gonadotropin releasing hormone agonist	0	0		low	0	0	0	0	0	0
leuprolide	0	oligopeptide	anti-estrogen; antineoplastic agent; gonadotropin releasing hormone agonist	0	0		low	0	0	0	0	0	0
mercaptopurine	2	aryl thiol; purines; thiocarbonyl compound	anticoronaviral agent; antimetabolite; antineoplastic agent	1993	2002	26.5	low	1	0	1	1	0	0
3,3',4,5'-tetrahydroxystilbene	0	catechols; polyphenol; resorcinols; stilbenol	antineoplastic agent; apoptosis inducer; geroprotector; hypoglycemic agent; plant metabolite; protein kinase inhibitor; tyrosine kinase inhibitor	0	0		low	0	0	0	0	0	0
iFSP1	0	aromatic amine; nitrile; primary amino compound; pyridobenzimidazole; toluenes	antineoplastic agent; ferroptosis inducer; ferroptosis suppressor protein 1 inhibitor	0	0		low	0	0	0	0	0	0
4-iodo-6-phenylpyrimidine	0	biaryl; organoiodine compound; pyrimidines	antineoplastic agent; apoptosis inducer; macrophage migration inhibitory factor inhibitor	0	0		low	0	0	0	0	0	0
oncrasin-1	0	arenecarbaldehyde; indoles; monochlorobenzenes	antineoplastic agent; apoptosis inducer	0	0		low	0	0	0	0	0	0
cct018159	0	benzodioxine; pyrazoles; resorcinols	antineoplastic agent; apoptosis inducer; Hsp90 inhibitor	0	0		low	0	0	0	0	0	0
sulindac	1	monocarboxylic acid; organofluorine compound; sulfoxide	analgesic; antineoplastic agent; antipyretic; apoptosis inducer; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug; prodrug; tocolytic agent	2014	2014	10.0	low	0	0	0	0	1	0
aurapten	0	coumarins; monoterpenoid	antihypertensive agent; antineoplastic agent; antioxidant; apoptosis inducer; dopaminergic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; gamma-secretase modulator; gastrointestinal drug; hepatoprotective agent; matrix metalloproteinase inhibitor; neuroprotective agent; plant metabolite; PPARalpha agonist; vulnerary	0	0		low	0	0	0	0	0	0
xl147	0	aromatic amine; benzothiadiazole; quinoxaline derivative; sulfonamide	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor	0	0		low	0	0	0	0	0	0
mcb-613	0	cyclic ketone; enone; pyridines	antineoplastic agent; steroid receptor coactivator stimulator	0	0		low	0	0	0	0	0	0
thioguanine anhydrous	3	2-aminopurines	anticoronaviral agent; antimetabolite; antineoplastic agent	1986	2003	30.0	low	0	1	1	1	0	0
tamoxifen	6	stilbenoid; tertiary amino compound	angiogenesis inhibitor; antineoplastic agent; bone density conservation agent; EC 1.2.3.1 (aldehyde oxidase) inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; estrogen antagonist; estrogen receptor antagonist; estrogen receptor modulator	1989	2019	19.8	low	1	1	1	3	1	0
stattic	0	1-benzothiophenes; C-nitro compound; sulfone	antineoplastic agent; radiosensitizing agent; STAT3 inhibitor	0	0		low	0	0	0	0	0	0
krn 7000	0	glycophytoceramide; N-acyl-beta-D-galactosylphytosphingosine	allergen; antigen; antineoplastic agent; epitope; immunological adjuvant	0	0		low	0	0	0	0	0	0
10058-F4	0	olefinic compound; thiazolidinone	antineoplastic agent; apoptosis inducer	0	0		low	0	0	0	0	0	0
monastrol	0	enoate ester; ethyl ester; phenols; racemate; thioureas	antileishmanial agent; antimitotic; antineoplastic agent; EC 3.5.1.5 (urease) inhibitor	0	0		low	0	0	0	0	0	0
toremifene	0	aromatic ether; organochlorine compound; tertiary amine	antineoplastic agent; bone density conservation agent; estrogen antagonist; estrogen receptor modulator	0	0		low	0	0	0	0	0	0
u 0126	0	aryl sulfide; dinitrile; enamine; substituted aniline	antineoplastic agent; antioxidant; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; osteogenesis regulator; vasoconstrictor agent	0	0		low	0	0	0	0	0	0
beauvericin	0	cyclodepsipeptide	antibiotic insecticide; antifungal agent; antineoplastic agent; apoptosis inhibitor; fungal metabolite; ionophore; mycotoxin; P450 inhibitor	0	0		low	0	0	0	0	0	0
nelarabine	0	beta-D-arabinoside; monosaccharide derivative; purine nucleoside	antineoplastic agent; DNA synthesis inhibitor; prodrug	0	0		low	0	0	0	0	0	0
bms 387032	0	1,3-oxazoles; 1,3-thiazoles; organic sulfide; piperidinecarboxamide; secondary carboxamide	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor	0	0		low	0	0	0	0	0	0
manool	0	labdane diterpenoid; tertiary alcohol	antibacterial agent; antineoplastic agent; plant metabolite	0	0		low	0	0	0	0	0	0
amrubicin	0	anthracycline antibiotic; methyl ketone; primary amino compound; quinone; tetracenes	antineoplastic agent; prodrug; topoisomerase II inhibitor	0	0		low	0	0	0	0	0	0
ospemifene	0	aromatic ether; organochlorine compound; primary alcohol	anti-inflammatory agent; antineoplastic agent; estrogen receptor modulator	0	0		low	0	0	0	0	0	0
tandutinib	0	aromatic ether; N-arylpiperazine; N-carbamoylpiperazine; phenylureas; piperidines; quinazolines; tertiary amino compound	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	0	0		low	0	0	0	0	0	0
dasatinib	1	1,3-thiazoles; aminopyrimidine; monocarboxylic acid amide; N-(2-hydroxyethyl)piperazine; N-arylpiperazine; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor	2016	2016	8.0	low	0	0	0	0	1	0
emetine dihydrochloride	0	hydrochloride	anticoronaviral agent; antimalarial; antineoplastic agent; antiprotozoal drug; antiviral agent; autophagy inhibitor; emetic; protein synthesis inhibitor	0	0		low	0	0	0	0	0	0
bigelovin	0	acetate ester; cyclic ketone; gamma-lactone; organic heterotricyclic compound; sesquiterpene lactone	antineoplastic agent; apoptosis inducer; immunomodulator; plant metabolite	0	0		low	0	0	0	0	0	0
zd 6474	0	aromatic ether; organobromine compound; organofluorine compound; piperidines; quinazolines; secondary amine	antineoplastic agent; tyrosine kinase inhibitor	0	0		low	0	0	0	0	0	0
l 663536	0	aryl sulfide; indoles; monocarboxylic acid; monochlorobenzenes	antineoplastic agent; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; leukotriene antagonist	0	0		low	0	0	0	0	0	0
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	0	benzenes; thiadiazolidine	anti-inflammatory agent; antineoplastic agent; apoptosis inducer; EC 2.7.11.26 (tau-protein kinase) inhibitor; neuroprotective agent	0	0		low	0	0	0	0	0	0
sc 560	0	aromatic ether; monochlorobenzenes; organofluorine compound; pyrazoles	angiogenesis modulating agent; antineoplastic agent; apoptosis inducer; cyclooxygenase 1 inhibitor; non-steroidal anti-inflammatory drug	0	0		low	0	0	0	0	0	0
alsterpaullone	0	C-nitro compound; caprolactams; organic heterotetracyclic compound	anti-HIV-1 agent; antineoplastic agent; apoptosis inducer; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor; EC 2.7.11.26 (tau-protein kinase) inhibitor	0	0		low	0	0	0	0	0	0
ginkgetin	0	biflavonoid; hydroxyflavone; methoxyflavone; ring assembly	anti-HSV-1 agent; antineoplastic agent; cyclooxygenase 2 inhibitor; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; metabolite	0	0		low	0	0	0	0	0	0
eupatilin	0	dihydroxyflavone; trimethoxyflavone	anti-inflammatory agent; anti-ulcer drug; antineoplastic agent; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; metabolite	0	0		low	0	0	0	0	0	0
quercetin	65	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger	1988	2023	14.2	low	1	2	3	27	27	6
biochanin a	0	4'-methoxyisoflavones; 7-hydroxyisoflavones	antineoplastic agent; EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor; phytoestrogen; plant metabolite; tyrosine kinase inhibitor	0	0		low	0	0	0	0	0	0
vitexin	0	C-glycosyl compound; trihydroxyflavone	antineoplastic agent; EC 3.2.1.20 (alpha-glucosidase) inhibitor; plant metabolite; platelet aggregation inhibitor	0	0		low	0	0	0	0	0	0
apigenin	9	trihydroxyflavone	antineoplastic agent; metabolite	2007	2021	9.2	low	0	0	0	2	6	1
luteolin	3	3'-hydroxyflavonoid; tetrahydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; c-Jun N-terminal kinase inhibitor; EC 2.3.1.85 (fatty acid synthase) inhibitor; immunomodulator; nephroprotective agent; plant metabolite; radical scavenger; vascular endothelial growth factor receptor antagonist	1990	2022	17.0	low	0	0	1	1	0	1
calcitriol	7	D3 vitamins; hydroxycalciol; triol	antineoplastic agent; antipsoriatic; bone density conservation agent; calcium channel agonist; calcium channel modulator; hormone; human metabolite; immunomodulator; metabolite; mouse metabolite; nutraceutical	1987	2021	17.9	low	0	1	1	2	2	1
herbacetin	0	7-hydroxyflavonol; pentahydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antilipemic drug; antineoplastic agent; apoptosis inducer; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; EC 4.1.1.17 (ornithine decarboxylase) inhibitor; plant metabolite	0	0		low	0	0	0	0	0	0
hymecromone	2	hydroxycoumarin	antineoplastic agent; hyaluronic acid synthesis inhibitor	1986	1997	32.5	low	0	1	1	0	0	0
chrysoeriol	0	monomethoxyflavone; trihydroxyflavone	antineoplastic agent; antioxidant; metabolite	0	0		low	0	0	0	0	0	0
dexmedetomidine	0	trihydroxyflavone; trimethoxyflavone	antineoplastic agent; metabolite	0	0		low	0	0	0	0	0	0
bryostatin 1	0	acetate ester; bryostatins; cyclic hemiketal; enoate ester; methyl ester; organic heterotetracyclic compound; secondary alcohol	alpha-secretase activator; anti-HIV-1 agent; antineoplastic agent; marine metabolite; protein kinase C agonist	0	0		low	0	0	0	0	0	0
quercetin 3-o-glucopyranoside	0	beta-D-glucoside; monosaccharide derivative; quercetin O-glucoside; tetrahydroxyflavone	antineoplastic agent; antioxidant; antipruritic drug; bone density conservation agent; geroprotector; histamine antagonist; osteogenesis regulator; plant metabolite	0	0		low	0	0	0	0	0	0

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	1990's	2000's	2010's
ci 994	0	acetamides; benzamides; substituted aniline	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamide	0	benzamides; hydroxamic acid; secondary carboxamide; tertiary amino compound	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0
entinostat	0	benzamides; carbamate ester; primary amino compound; pyridines; substituted aniline	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0
sirtinol	0	aldimine; benzamides; naphthols	anti-inflammatory agent; EC 3.5.1.98 (histone deacetylase) inhibitor; Sir2 inhibitor	0	0		low	0	0	0
panobinostat	0	cinnamamides; hydroxamic acid; methylindole; secondary amino compound	angiogenesis modulating agent; antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor	0	0		low	0	0	0
aminoglutethimide	3	dicarboximide; piperidones; substituted aniline	adrenergic agent; anticonvulsant; antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor	2006	2015	14.7	low	0	2	1
cl 387785	0	bromobenzenes; quinazolines; secondary carboxamide; ynamide	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; epidermal growth factor receptor antagonist	0	0		low	0	0	0
meclofenamic acid	2	aminobenzoic acid; organochlorine compound; secondary amino compound	analgesic; anticonvulsant; antineoplastic agent; antipyretic; antirheumatic drug; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-steroidal anti-inflammatory drug	1992	1995	30.5	low	2	0	0
n(1), n(12)-diethylspermine	0	polyazaalkane; secondary amino compound; substituted spermine; tetramine	antineoplastic agent	0	0		low	0	0	0
pd 158780	0	aromatic amine; bromobenzenes; diamine; pyridopyrimidine; secondary amino compound	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	0	0		low	0	0	0
pj-34	0	phenanthridines; secondary carboxamide; tertiary amino compound	angiogenesis inhibitor; anti-inflammatory agent; antiatherosclerotic agent; antineoplastic agent; apoptosis inducer; cardioprotective agent; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; neuroprotective agent	0	0		low	0	0	0
procarbazine	2	benzamides; hydrazines	antineoplastic agent	1991	1993	32.0	low	2	0	0
imatinib	0	aromatic amine; benzamides; N-methylpiperazine; pyridines; pyrimidines	antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor	0	0		low	0	0	0
streptonigrin	0	pyridines; quinolone	antimicrobial agent; antineoplastic agent	0	0		low	0	0	0
suramin	2	naphthalenesulfonic acid; phenylureas; secondary carboxamide	angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug	1996	2019	16.5	low	1	0	1
nimustine	0	aminopyrimidine; N-nitrosoureas; organochlorine compound	alkylating agent; antineoplastic agent	0	0		low	0	0	0
nelfinavir	0	aryl sulfide; benzamides; organic heterobicyclic compound; phenols; secondary alcohol; tertiary amino compound	antineoplastic agent; HIV protease inhibitor	0	0		low	0	0	0
plerixafor	0	azacycloalkane; azamacrocycle; benzenes; crown amine; secondary amino compound; tertiary amino compound	anti-HIV agent; antineoplastic agent; C-X-C chemokine receptor type 4 antagonist; immunological adjuvant	0	0		low	0	0	0
marimastat	0	hydroxamic acid; secondary carboxamide	antineoplastic agent; matrix metalloproteinase inhibitor	0	0		low	0	0	0
gefitinib	0	aromatic ether; monochlorobenzenes; monofluorobenzenes; morpholines; quinazolines; secondary amino compound; tertiary amino compound	antineoplastic agent; epidermal growth factor receptor antagonist	0	0		low	0	0	0
nsc 224070	0	1,4-benzoquinones; aziridines; enamine; primary alcohol; secondary amino compound	alkylating agent; antineoplastic agent	0	0		low	0	0	0
abiraterone	0	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; pyridines	antineoplastic agent; EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor	0	0		low	0	0	0
vatalanib	0	monochlorobenzenes; phthalazines; pyridines; secondary amino compound	angiogenesis inhibitor; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; vascular endothelial growth factor receptor antagonist	0	0		low	0	0	0
cyc 682	0	nitrile; nucleoside analogue; secondary carboxamide	antimetabolite; antineoplastic agent; DNA synthesis inhibitor; prodrug	0	0		low	0	0	0
actinodaphine	0	aporphine alkaloid; aromatic ether; organic heteropentacyclic compound; phenols; secondary amino compound	antibacterial agent; antifungal agent; antineoplastic agent; apoptosis inducer; plant metabolite; platelet aggregation inhibitor; topoisomerase inhibitor	0	0		low	0	0	0
asperphenamate	0	benzamides; carboxylic ester; L-phenylalanine derivative	antineoplastic agent	0	0		low	0	0	0
erlotinib	0	aromatic ether; quinazolines; secondary amino compound; terminal acetylenic compound	antineoplastic agent; epidermal growth factor receptor antagonist; protein kinase inhibitor	0	0		low	0	0	0
2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0	morpholines; purines; secondary amino compound; tertiary amino compound	adenosine A3 receptor antagonist; antineoplastic agent; Aurora kinase inhibitor; cell dedifferentiation agent	0	0		low	0	0	0
demecolcine	1	alkaloid; secondary amino compound	antineoplastic agent; microtubule-destabilising agent	1990	1990	34.0	low	1	0	0
gant 61	0	aminal; dialkylarylamine; pyridines; substituted aniline; tertiary amino compound	antineoplastic agent; apoptosis inducer; glioma-associated oncogene inhibitor; Hedgehog signaling pathway inhibitor	0	0		low	0	0	0
prinomastat	0	aromatic ether; hydroxamic acid; pyridines; sulfonamide; thiomorpholines	antineoplastic agent; EC 3.4.24.35 (gelatinase B) inhibitor; matrix metalloproteinase inhibitor	0	0		low	0	0	0
s 1033	0	(trifluoromethyl)benzenes; imidazoles; pyridines; pyrimidines; secondary amino compound; secondary carboxamide	anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor	0	0		low	0	0	0
mcb-613	0	cyclic ketone; enone; pyridines	antineoplastic agent; steroid receptor coactivator stimulator	0	0		low	0	0	0
u 0126	0	aryl sulfide; dinitrile; enamine; substituted aniline	antineoplastic agent; antioxidant; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; osteogenesis regulator; vasoconstrictor agent	0	0		low	0	0	0
bms 387032	0	1,3-oxazoles; 1,3-thiazoles; organic sulfide; piperidinecarboxamide; secondary carboxamide	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor	0	0		low	0	0	0
dasatinib	1	1,3-thiazoles; aminopyrimidine; monocarboxylic acid amide; N-(2-hydroxyethyl)piperazine; N-arylpiperazine; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor	2016	2016	8.0	low	0	0	1
tranilast	0	amidobenzoic acid; cinnamamides; dimethoxybenzene; secondary carboxamide	anti-allergic agent; anti-asthmatic drug; antineoplastic agent; aryl hydrocarbon receptor agonist; calcium channel blocker; hepatoprotective agent; nephroprotective agent	0	0		low	0	0	0
palbociclib	0	aminopyridine; aromatic ketone; cyclopentanes; piperidines; pyridopyrimidine; secondary amino compound; tertiary amino compound	antineoplastic agent; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor	0	0		low	0	0	0
batimastat	0	hydroxamic acid; L-phenylalanine derivative; organic sulfide; secondary carboxamide; thiophenes; triamide	angiogenesis inhibitor; antineoplastic agent; matrix metalloproteinase inhibitor	0	0		low	0	0	0
pederin	0	cyclic ketal; diol; oxanes; polyketide; secondary alcohol; secondary carboxamide	antimitotic; antineoplastic agent; bacterial metabolite; vesicant	0	0		low	0	0	0
3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	0	enone; pyridines	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; autophagy inducer; EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor	0	0		low	0	0	0
manumycin	0	enamide; epoxide; organic heterobicyclic compound; polyketide; secondary carboxamide; tertiary alcohol	antiatherosclerotic agent; antimicrobial agent; antineoplastic agent; apoptosis inducer; bacterial metabolite; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.5.1.58 (protein farnesyltransferase) inhibitor; marine metabolite	0	0		low	0	0	0
asukamycin	0	enamide; epoxide; organic heterobicyclic compound; polyketide; secondary carboxamide; tertiary alcohol	antibacterial agent; antifungal agent; antimicrobial agent; antineoplastic agent; bacterial metabolite	0	0		low	0	0	0
axitinib	0	aryl sulfide; benzamides; indazoles; pyridines	antineoplastic agent; tyrosine kinase inhibitor; vascular endothelial growth factor receptor antagonist	0	0		low	0	0	0
l 744832	0	benzenes; ether; isopropyl ester; secondary carboxamide; sulfone; thiol	antineoplastic agent; EC 2.5.1.58 (protein farnesyltransferase) inhibitor; geroprotector	0	0		low	0	0	0
tanespimycin	0	1,4-benzoquinones; ansamycin; carbamate ester; organic heterobicyclic compound; secondary amino compound	antineoplastic agent; apoptosis inducer; Hsp90 inhibitor	0	0		low	0	0	0
abiraterone acetate	0	pyridines; sterol ester	antineoplastic agent; EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor; prodrug	0	0		low	0	0	0
pd 0325901	0	difluorobenzene; hydroxamic acid ester; monofluorobenzenes; organoiodine compound; propane-1,2-diols; secondary amino compound	antineoplastic agent; EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor	0	0		low	0	0	0
midostaurin	0	benzamides; gamma-lactam; indolocarbazole; organic heterooctacyclic compound	antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor	0	0		low	0	0	0
zm 447439	0	aromatic ether; benzamides; morpholines; polyether; quinazolines; secondary amino compound; tertiary amino compound	antineoplastic agent; apoptosis inducer; Aurora kinase inhibitor	0	0		low	0	0	0
rucaparib	0	azepinoindole; caprolactams; organofluorine compound; secondary amino compound	antineoplastic agent; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor	0	0		low	0	0	0
sch 51344	0	aromatic amine; aromatic ether; primary alcohol; pyrazoloquinoline; secondary amino compound	antineoplastic agent	0	0		low	0	0	0
masitinib	0	1,3-thiazoles; benzamides; N-alkylpiperazine; pyridines	antineoplastic agent; antirheumatic drug; tyrosine kinase inhibitor	0	0		low	0	0	0
avenanthramide b	0	amidobenzoic acid; cinnamamides; monohydroxybenzoic acid; monomethoxybenzene; phenols; secondary carboxamide	antineoplastic agent; apoptosis inducer; phytoalexin	0	0		low	0	0	0
pazopanib	0	aminopyrimidine; indazoles; sulfonamide	angiogenesis modulating agent; antineoplastic agent; tyrosine kinase inhibitor; vascular endothelial growth factor receptor antagonist	0	0		low	0	0	0
azd 6244	0	benzimidazoles; bromobenzenes; hydroxamic acid ester; monochlorobenzenes; organofluorine compound; secondary amino compound	anticoronaviral agent; antineoplastic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	0	0		low	0	0	0
azd2858	0	aromatic amine; N-methylpiperazine; pyrazines; pyridines; secondary carboxamide; sulfonamide	antineoplastic agent; bone density conservation agent; EC 2.7.11.26 (tau-protein kinase) inhibitor; Wnt signalling activator	0	0		low	0	0	0
bibw 2992	0	aromatic ether; enamide; furans; monochlorobenzenes; organofluorine compound; quinazolines; secondary carboxamide; tertiary amino compound	antineoplastic agent; tyrosine kinase inhibitor	0	0		low	0	0	0
binimetinib	0	benzimidazoles; bromobenzenes; hydroxamic acid ester; monofluorobenzenes; secondary amino compound	antineoplastic agent; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	0	0		low	0	0	0
saracatinib	0	aromatic ether; benzodioxoles; diether; N-methylpiperazine; organochlorine compound; oxanes; quinazolines; secondary amino compound	anticoronaviral agent; antineoplastic agent; apoptosis inducer; autophagy inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; radiosensitizing agent	0	0		low	0	0	0
pha 665752	0	dichlorobenzene; enamide; indolones; N-acylpyrrolidine; pyrrolecarboxamide; secondary carboxamide; sulfone; tertiary carboxamide	antineoplastic agent; c-Met tyrosine kinase inhibitor	0	0		low	0	0	0
abt-737	0	aromatic amine; aryl sulfide; biphenyls; C-nitro compound; monochlorobenzenes; N-arylpiperazine; N-sulfonylcarboxamide; secondary amino compound; tertiary amino compound	anti-allergic agent; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor	0	0		low	0	0	0
at 7519	0	dichlorobenzene; piperidines; pyrazoles; secondary carboxamide	antineoplastic agent; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor	0	0		low	0	0	0
azd 1152	0	anilide; monoalkyl phosphate; monofluorobenzenes; pyrazoles; quinazolines; secondary amino compound; secondary carboxamide; tertiary amino compound	antineoplastic agent; Aurora kinase inhibitor; prodrug	0	0		low	0	0	0
pf 00299804	0	enamide; monochlorobenzenes; monofluorobenzenes; piperidines; quinazolines; secondary amino compound; secondary carboxamide; tertiary amino compound	antineoplastic agent; epidermal growth factor receptor antagonist	0	0		low	0	0	0
ki11502	0	aromatic ether; benzamides; quinolines; thioureas	antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	0	0		low	0	0	0
idelalisib	0	aromatic amine; organofluorine compound; purines; quinazolines; secondary amino compound	antineoplastic agent; apoptosis inducer; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor	0	0		low	0	0	0
GDC-0879	0	indanes; ketoxime; primary alcohol; pyrazoles; pyridines	antineoplastic agent; B-Raf inhibitor	0	0		low	0	0	0
at 13387	0	benzamides; isoindoles; N-alkylpiperazine; resorcinols; tertiary carboxamide	antineoplastic agent; Hsp90 inhibitor	0	0		low	0	0	0
bgt226	0	aromatic ether; imidazoquinoline; N-arylpiperazine; organofluorine compound; pyridines	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor	0	0		low	0	0	0
mdv 3100	0	(trifluoromethyl)benzenes; benzamides; imidazolidinone; monofluorobenzenes; nitrile; thiocarbonyl compound	androgen antagonist; antineoplastic agent	0	0		low	0	0	0
azd 1152-hqpa	0	anilide; monofluorobenzenes; primary alcohol; pyrazoles; quinazolines; secondary amino compound; secondary carboxamide; tertiary amino compound	antineoplastic agent; Aurora kinase inhibitor	0	0		low	0	0	0
gdc-0973	0	aromatic amine; difluorobenzene; N-acylazetidine; organoiodine compound; piperidines; secondary amino compound; tertiary alcohol	antineoplastic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	0	0		low	0	0	0
buparlisib	0	aminopyridine; aminopyrimidine; morpholines; organofluorine compound	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor	0	0		low	0	0	0
ro5126766	0	aryloxypyrimidine; coumarins; organofluorine compound; pyridines; sulfamides	antineoplastic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	0	0		low	0	0	0
pevonedistat	0	cyclopentanols; indanes; pyrrolopyrimidine; secondary amino compound; sulfamidate	antineoplastic agent; apoptosis inducer	0	0		low	0	0	0
tg101209	0	N-alkylpiperazine; N-arylpiperazine; pyrimidines; secondary amino compound; sulfonamide	antineoplastic agent; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor	0	0		low	0	0	0
cnf 2024	0	2-aminopurines; aromatic ether; organochlorine compound; pyridines	antineoplastic agent; Hsp90 inhibitor	0	0		low	0	0	0
respirantin	0	benzamides; cyclodepsipeptide; formamides; phenols	antimicrobial agent; antineoplastic agent; metabolite	0	0		low	0	0	0
sm 164	0	benzenes; organic heterobicyclic compound; secondary carboxamide; triazoles	antineoplastic agent; apoptosis inducer; radiosensitizing agent	0	0		low	0	0	0
lde225	0	aminopyridine; aromatic ether; benzamides; biphenyls; morpholines; organofluorine compound; tertiary amino compound	antineoplastic agent; Hedgehog signaling pathway inhibitor; SMO receptor antagonist	0	0		low	0	0	0
gdc 0449	0	benzamides; monochlorobenzenes; pyridines; sulfone	antineoplastic agent; Hedgehog signaling pathway inhibitor; SMO receptor antagonist; teratogenic agent	0	0		low	0	0	0
bms 754807	0	pyrazoles; pyridines; pyrrolidines; pyrrolotriazine	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	0	0		low	0	0	0
ponatinib	0	(trifluoromethyl)benzenes; acetylenic compound; benzamides; imidazopyridazine; N-methylpiperazine	antineoplastic agent; tyrosine kinase inhibitor	0	0		low	0	0	0
sch772984	0	biaryl; indazoles; N-acylpiperazine; N-alkylpyrrolidine; N-arylpiperazine; pyridines; pyrimidines; pyrrolidinecarboxamide; secondary carboxamide; tertiary amino compound; tertiary carboxamide	analgesic; antineoplastic agent; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	0	0		low	0	0	0
navitoclax	0	aryl sulfide; monochlorobenzenes; morpholines; N-sulfonylcarboxamide; organofluorine compound; piperazines; secondary amino compound; sulfone; tertiary amino compound	antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor	0	0		low	0	0	0
n-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide	0	aminopyrimidine; benzamides; morpholines; nitrile; secondary amino compound; tertiary amino compound	anti-anaemic agent; antineoplastic agent; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor	0	0		low	0	0	0
poziotinib	0	acrylamides; aromatic ether; dichlorobenzene; diether; monofluorobenzenes; N-acylpiperidine; quinazolines; secondary amino compound; substituted aniline	antineoplastic agent; apoptosis inducer; epidermal growth factor receptor antagonist	0	0		low	0	0	0
asp3026	0	aromatic amine; diamino-1,3,5-triazine; monomethoxybenzene; N-methylpiperazine; piperidines; secondary amino compound; sulfone	antimalarial; antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; EC 6.1.1.6 (lysine--tRNA ligase) inhibitor	0	0		low	0	0	0
entrectinib	0	benzamides; difluorobenzene; indazoles; N-methylpiperazine; oxanes; secondary amino compound; secondary carboxamide	antibacterial agent; antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	0	0		low	0	0	0
pexidartinib	0	aminopyridine; organochlorine compound; organofluorine compound; pyrrolopyridine; secondary amino compound	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	0	0		low	0	0	0
TAK-580	0	1,3-thiazolecarboxamide; aminopyrimidine; chloropyridine; organofluorine compound; pyrimidinecarboxamide; secondary carboxamide	antineoplastic agent; apoptosis inducer; B-Raf inhibitor	0	0		low	0	0	0
gsk 2126458	0	aromatic ether; difluorobenzene; pyridazines; pyridines; quinolines; sulfonamide	anticoronaviral agent; antineoplastic agent; autophagy inducer; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor; radiosensitizing agent	0	0		low	0	0	0
ixazomib	0	benzamides; boronic acids; dichlorobenzene; glycine derivative	antineoplastic agent; apoptosis inducer; drug metabolite; orphan drug; proteasome inhibitor	0	0		low	0	0	0
cx 5461	0	diazepine; naphthyridine derivative; organic heterotetracyclic compound; pyrazines; secondary carboxamide	antineoplastic agent; apoptosis inducer; EC 2.7.7.6 (RNA polymerase) inhibitor	0	0		low	0	0	0
GDC-0623	0	hydroxamic acid ester; imidazopyridine; monofluorobenzenes; organoiodine compound; primary alcohol; secondary amino compound; substituted aniline	antineoplastic agent; apoptosis inducer; EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor	0	0		low	0	0	0
dabrafenib	0	1,3-thiazoles; aminopyrimidine; organofluorine compound; sulfonamide	anticoronaviral agent; antineoplastic agent; B-Raf inhibitor	0	0		low	0	0	0
cblc137	0	aromatic ketone; carbazoles; methyl ketone; secondary amino compound; tertiary amino compound	antineoplastic agent; apoptosis inducer; NF-kappaB inhibitor; p53 activator	0	0		low	0	0	0
EG00229	0	benzothiadiazole; dicarboxylic acid monoamide; L-arginine derivative; secondary carboxamide; sulfonamide; thiophenes	angiogenesis inhibitor; antineoplastic agent; neuropilin receptor antagonist	0	0		low	0	0	0
tak-632	0	(trifluoromethyl)benzenes; aromatic ether; benzothiazoles; cyclopropylcarboxamide; monofluorobenzenes; nitrile; secondary carboxamide	antineoplastic agent; apoptosis inducer; B-Raf inhibitor; EC 2.7.11.26 (tau-protein kinase) inhibitor; necroptosis inhibitor	0	0		low	0	0	0
lrrk2-in1	0	aromatic amine; aromatic ether; N-acylpiperidine; N-alkylpiperazine; pyrimidobenzodiazepine; secondary amino compound; tertiary amino compound	antineoplastic agent; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor	0	0		low	0	0	0
gilteritinib	0	aromatic amine; monomethoxybenzene; N-methylpiperazine; oxanes; piperidines; primary carboxamide; pyrazines; secondary amino compound	antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	0	0		low	0	0	0
ML240	0	aromatic amine; aromatic ether; benzimidazoles; primary amino compound; quinazolines; secondary amino compound	antineoplastic agent	0	0		low	0	0	0
xl765	0	aromatic amine; aromatic ether; benzamides; quinoxaline derivative; sulfonamide	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor	0	0		low	0	0	0
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea	0	aminopyrimidine; dichlorobenzene; N-alkylpiperazine; N-arylpiperazine; phenylureas	antineoplastic agent; fibroblast growth factor receptor antagonist	0	0		low	0	0	0
chir 98014	0	aminopyrimidine; C-nitro compound; diaminopyridine; dichlorobenzene; imidazoles; secondary amino compound	antineoplastic agent; apoptosis inducer; EC 2.7.11.26 (tau-protein kinase) inhibitor; hypoglycemic agent; tau aggregation inhibitor; Wnt signalling activator	0	0		low	0	0	0
lfm a13	0	aromatic amide; dibromobenzene; enamide; enol; nitrile; secondary carboxamide	antineoplastic agent; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 2.7.11.21 (polo kinase) inhibitor; geroprotector; platelet aggregation inhibitor	0	0		low	0	0	0
AZD3463	0	aminopiperidine; aminopyrimidine; indoles; monomethoxybenzene; organochlorine compound; secondary amino compound; tertiary amino compound	antineoplastic agent; apoptosis inducer; autophagy inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	0	0		low	0	0	0
ceritinib	0	aminopyrimidine; aromatic ether; organochlorine compound; piperidines; secondary amino compound; sulfone	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	0	0		low	0	0	0
MK-8353	0	aromatic ether; dihydropyridine; indazoles; methyl sulfide; N-alkylpyrrolidine; pyridines; pyrrolidinecarboxamide; secondary carboxamide; tertiary carboxamide; triazoles	antineoplastic agent; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	0	0		low	0	0	0
gsk2879552	0	benzenes; benzoic acids; cyclopropanes; monocarboxylic acid; piperidines; secondary amino compound; tertiary amino compound	antineoplastic agent; EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor	0	0		low	0	0	0
acp-196	0	aromatic amine; benzamides; imidazopyrazine; pyridines; pyrrolidinecarboxamide; secondary carboxamide; tertiary carboxamide; ynone	antineoplastic agent; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor	0	0		low	0	0	0
gsk343	0	aminopyridine; indazoles; N-alkylpiperazine; N-arylpiperazine; pyridone; secondary carboxamide	antineoplastic agent; apoptosis inducer; EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor	0	0		low	0	0	0
GSK1059615	0	pyridines; quinolines; thiazolidinone	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor	0	0		low	0	0	0
osimertinib	0	acrylamides; aminopyrimidine; biaryl; indoles; monomethoxybenzene; secondary amino compound; secondary carboxamide; substituted aniline; tertiary amino compound	antineoplastic agent; epidermal growth factor receptor antagonist	0	0		low	0	0	0
ivosidenib	0	cyanopyridine; monochlorobenzenes; organofluorine compound; pyrrolidin-2-ones; secondary carboxamide; tertiary carboxamide	antineoplastic agent; EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor	0	0		low	0	0	0
ly3009120	0	aminotoluene; aromatic amine; biaryl; monofluorobenzenes; phenylureas; pyridopyrimidine; secondary amino compound	antineoplastic agent; apoptosis inducer; autophagy inducer; B-Raf inhibitor; necroptosis inhibitor	0	0		low	0	0	0
pf-06463922	0	aminopyridine; aromatic ether; azamacrocycle; benzamides; cyclic ether; monofluorobenzenes; nitrile; organic heterotetracyclic compound; pyrazoles	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	0	0		low	0	0	0
as 1842856	0	organofluorine compound; primary amino compound; quinolinemonocarboxylic acid; quinolone; secondary amino compound; tertiary amino compound	anti-obesity agent; antineoplastic agent; apoptosis inducer; autophagy inhibitor; forkhead box protein O1 inhibitor; hypoglycemic agent	0	0		low	0	0	0
ldc4297	0	aromatic ether; piperidines; pyrazoles; pyrazolotriazine; secondary amino compound	antineoplastic agent; antiviral agent; apoptosis inducer; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor	0	0		low	0	0	0
hg-9-91-01	0	aminopyrimidine; dimethoxybenzene; N-alkylpiperazine; N-arylpiperazine; phenylureas; secondary amino compound	antineoplastic agent; salt-inducible kinase 2 inhibitor	0	0		low	0	0	0
enasidenib	0	1,3,5-triazines; aminopyridine; aromatic amine; organofluorine compound; secondary amino compound; tertiary alcohol	antineoplastic agent; EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor	0	0		low	0	0	0
BDA-366	0	anthraquinone; epoxide; secondary alcohol; secondary amino compound; tertiary amino compound	antineoplastic agent; apoptosis inducer	0	0		low	0	0	0
THZ531	0	aminopyrimidine; enamide; indoles; N-acylpiperidine; organochlorine compound; secondary amino compound; secondary carboxamide	antineoplastic agent; apoptosis inducer; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor	0	0		low	0	0	0
MMP-9-IN-1	0	aromatic compound; organic sulfide; organofluorine compound; pyrimidone; secondary carboxamide	antineoplastic agent; EC 3.4.24.35 (gelatinase B) inhibitor	0	0		low	0	0	0
2-hydroxy-3-(5-((morpholin-4-yl)methyl)pyridin-2-yl)-1h-indole-5-carbonitrile	0	hydroxyindoles; morpholines; nitrile; pyridines; tertiary amino compound	antineoplastic agent; apoptosis inducer; EC 2.7.11.26 (tau-protein kinase) inhibitor; tau aggregation inhibitor	0	0		low	0	0	0
pioglitazone	12	aromatic ether; pyridines; thiazolidinediones	antidepressant; cardioprotective agent; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; geroprotector; hypoglycemic agent; insulin-sensitizing drug; PPARgamma agonist; xenobiotic	2002	2018	13.6	low	0	6	6
liproxstatin-1	0	azaspiro compound; monochlorobenzenes; organic heterotricyclic compound; secondary amino compound	antioxidant; cardioprotective agent; ferroptosis inhibitor; radical scavenger	0	0		low	0	0	0
droxicam	0	organic heterotricyclic compound; pyridines	cyclooxygenase 1 inhibitor; hepatotoxic agent; non-narcotic analgesic; non-steroidal anti-inflammatory drug; platelet aggregation inhibitor; prodrug	0	0		low	0	0	0
mepanipyrim	0	acetylenic compound; aminopyrimidine; anilinopyrimidine fungicide; secondary amino compound	antifungal agrochemical; aryl hydrocarbon receptor agonist; hepatotoxic agent	0	0		low	0	0	0
teriflunomide	0	(trifluoromethyl)benzenes; aromatic amide; enamide; enol; nitrile; secondary carboxamide	drug metabolite; EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor; hepatotoxic agent; non-steroidal anti-inflammatory drug; tyrosine kinase inhibitor	0	0		low	0	0	0
niclosamide	0	benzamides; C-nitro compound; monochlorobenzenes; salicylanilides; secondary carboxamide	anthelminthic drug; anticoronaviral agent; antiparasitic agent; apoptosis inducer; molluscicide; piscicide; STAT3 inhibitor	0	0		low	0	0	0
sb 202190	0	imidazoles; organofluorine compound; phenols; pyridines	apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	0	0		low	0	0	0
n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine	0	N-substituted diamine; pyridines; tertiary amino compound	apoptosis inducer; chelator; copper chelator	0	0		low	0	0	0
fluazinam	0	(trifluoromethyl)benzenes; aminopyridine; C-nitro compound; chloropyridine; monochlorobenzenes; secondary amino compound	allergen; antifungal agrochemical; apoptosis inducer; environmental contaminant; xenobiotic	0	0		low	0	0	0
nsc 23766	0	aminopyrimidine; aminoquinoline; primary amino compound; secondary amino compound; tertiary amino compound	antiviral agent; apoptosis inducer; EC 3.6.5.2 (small monomeric GTPase) inhibitor; muscarinic antagonist	0	0		low	0	0	0
sb 415286	0	C-nitro compound; maleimides; monochlorobenzenes; phenols; secondary amino compound; substituted aniline	antioxidant; apoptosis inducer; EC 2.7.11.26 (tau-protein kinase) inhibitor; neuroprotective agent	0	0		low	0	0	0
ag-490	0	catechols; enamide; monocarboxylic acid amide; nitrile; secondary carboxamide	anti-inflammatory agent; antioxidant; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; geroprotector; STAT3 inhibitor	0	0		low	0	0	0
pipercallosidine	0	alkaloid; benzodioxoles; enamide; secondary carboxamide	apoptosis inducer; metabolite; plant metabolite	0	0		low	0	0	0
MI-63	0	azaspiro compound; monochlorobenzenes; monofluorobenzenes; morpholines; oxindoles; pyrrolidines; secondary carboxamide	apoptosis inducer	0	0		low	0	0	0
SMER 28	0	organobromine compound; quinazolines; secondary amino compound	autophagy inducer	0	0		low	0	0	0
AZ3451	0	benzimidazoles; benzodioxoles; nitrile; organobromine compound; secondary carboxamide	anti-inflammatory agent; autophagy inducer; PAR2 negative allosteric modulator	0	0		low	0	0	0
((5z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4h-imidazol-4-one)	0	benzodioxoles; imidazolone; substituted aniline	autophagy inducer; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor; EC 2.7.12.1 (dual-specificity kinase) inhibitor; neuroprotective agent; nootropic agent	0	0		low	0	0	0

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's	post-2020
aminolevulinic acid	1	4-oxo monocarboxylic acid; amino acid zwitterion; delta-amino acid	antineoplastic agent; dermatologic drug; Escherichia coli metabolite; human metabolite; mouse metabolite; photosensitizing agent; plant metabolite; prodrug; Saccharomyces cerevisiae metabolite	2023	2023	1.0	low	0	0	1
coumarin	1	coumarins	fluorescent dye; human metabolite; plant metabolite	2023	2023	1.0	low	0	0	1
salicylic acid	1	monohydroxybenzoic acid	algal metabolite; antifungal agent; antiinfective agent; EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor; keratolytic drug; plant hormone; plant metabolite	2023	2023	1.0	low	0	0	1
thioctic acid	1	dithiolanes; heterocyclic fatty acid; thia fatty acid	fundamental metabolite; geroprotector	2023	2023	1.0	low	0	0	1
picolinic acid	1	pyridinemonocarboxylic acid	human metabolite; MALDI matrix material	2023	2023	1.0	low	0	0	1
thiamine	1	primary alcohol; vitamin B1	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2023	2023	1.0	low	0	0	1
pk 11195	1	aromatic amide; isoquinolines; monocarboxylic acid amide; monochlorobenzenes	antineoplastic agent	2013	2013	11.0	low	0	1	0
pd 173074	1	aromatic amine; biaryl; dimethoxybenzene; pyridopyrimidine; tertiary amino compound; ureas	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; fibroblast growth factor receptor antagonist	2013	2013	11.0	low	0	1	0
3-aminobenzamide	1	benzamides; substituted aniline	EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor	2023	2023	1.0	low	0	0	1
pleconaril	1			2023	2023	1.0	low	0	0	1
4-(2-aminoethyl)benzenesulfonylfluoride	1			2023	2023	1.0	low	0	0	1
phenytoin	1	imidazolidine-2,4-dione	anticonvulsant; drug allergen; sodium channel blocker; teratogenic agent	2023	2023	1.0	low	0	0	1
abt 702	1	bipyridines		2013	2013	11.0	low	0	1	0
acetazolamide	1	monocarboxylic acid amide; sulfonamide; thiadiazoles	anticonvulsant; diuretic; EC 4.2.1.1 (carbonic anhydrase) inhibitor	2023	2023	1.0	low	0	0	1
alprenolol	1	secondary alcohol; secondary amino compound	anti-arrhythmia drug; antihypertensive agent; beta-adrenergic antagonist; sympatholytic agent	2023	2023	1.0	low	0	0	1
amantadine	1	adamantanes; primary aliphatic amine	analgesic; antiparkinson drug; antiviral drug; dopaminergic agent; NMDA receptor antagonist; non-narcotic analgesic	2023	2023	1.0	low	0	0	1
2-aminothiazole	1	1,3-thiazoles; primary amino compound		2023	2023	1.0	low	0	0	1
amodiaquine	1	aminoquinoline; organochlorine compound; phenols; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; drug allergen; EC 2.1.1.8 (histamine N-methyltransferase) inhibitor; non-steroidal anti-inflammatory drug; prodrug	2023	2023	1.0	low	0	0	1
aspirin	1	benzoic acids; phenyl acetates; salicylates	anticoagulant; antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; EC 1.1.1.188 (prostaglandin-F synthase) inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; plant activator; platelet aggregation inhibitor; prostaglandin antagonist; teratogenic agent	2023	2023	1.0	low	0	0	1
baclofen	1	amino acid zwitterion; gamma-amino acid; monocarboxylic acid; monochlorobenzenes; primary amino compound	central nervous system depressant; GABA agonist; muscle relaxant	2023	2023	1.0	low	0	0	1
benzamide	1	benzamides		2023	2023	1.0	low	0	0	1
bicalutamide	1	(trifluoromethyl)benzenes; monocarboxylic acid amide; monofluorobenzenes; nitrile; sulfone; tertiary alcohol		2013	2013	11.0	low	0	1	0
verapamil	1	aromatic ether; nitrile; polyether; tertiary amino compound		2013	2013	11.0	low	0	1	0
camostat	1	benzoate ester; carboxylic ester; diester; guanidines; tertiary carboxamide	anti-inflammatory agent; anticoronaviral agent; antifibrinolytic drug; antihypertensive agent; antineoplastic agent; antiviral agent; serine protease inhibitor	2023	2023	1.0	low	0	0	1
camphor, (+-)-isomer	1	bornane monoterpenoid; cyclic monoterpene ketone	plant metabolite	2023	2023	1.0	low	0	0	1
candesartan	1	benzimidazolecarboxylic acid; biphenylyltetrazole	angiotensin receptor antagonist; antihypertensive agent; environmental contaminant; xenobiotic	2023	2023	1.0	low	0	0	1
celecoxib	1	organofluorine compound; pyrazoles; sulfonamide; toluenes	cyclooxygenase 2 inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug	2013	2013	11.0	low	0	1	0
cetylpyridinium	1	pyridinium ion		2023	2023	1.0	low	0	0	1
chelerythrine	1	benzophenanthridine alkaloid; organic cation	antibacterial agent; antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor	2013	2013	11.0	low	0	1	0
chloroxylenol	1	monochlorobenzenes; phenols	antiseptic drug; disinfectant; molluscicide	2023	2023	1.0	low	0	0	1
chlorpromazine	1	organochlorine compound; phenothiazines; tertiary amine	anticoronaviral agent; antiemetic; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; phenothiazine antipsychotic drug	2023	2023	1.0	low	0	0	1
ci 994	1	acetamides; benzamides; substituted aniline	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor	2010	2010	14.0	low	1	0	0
ciprofibrate	1	cyclopropanes; monocarboxylic acid; organochlorine compound	antilipemic drug	2023	2023	1.0	low	0	0	1
clomipramine	1	dibenzoazepine	anticoronaviral agent; antidepressant; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; serotonergic antagonist; serotonergic drug; serotonin uptake inhibitor	2023	2023	1.0	low	0	0	1
danthron	1	dihydroxyanthraquinone	apoptosis inducer; plant metabolite	2023	2023	1.0	low	0	0	1
deferiprone	1	4-pyridones	iron chelator; protective agent	2023	2023	1.0	low	0	0	1
dipyridamole	1	piperidines; pyrimidopyrimidine; tertiary amino compound; tetrol	adenosine phosphodiesterase inhibitor; EC 3.5.4.4 (adenosine deaminase) inhibitor; platelet aggregation inhibitor; vasodilator agent	2023	2023	1.0	low	0	0	1
disulfiram	1	organic disulfide; organosulfur acaricide	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor; EC 3.1.1.1 (carboxylesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 5.99.1.2 (DNA topoisomerase) inhibitor; ferroptosis inducer; fungicide; NF-kappaB inhibitor	2023	2023	1.0	low	0	0	1
valproic acid	1	branched-chain fatty acid; branched-chain saturated fatty acid	anticonvulsant; antimanic drug; EC 3.5.1.98 (histone deacetylase) inhibitor; GABA agent; neuroprotective agent; psychotropic drug; teratogenic agent	2023	2023	1.0	low	0	0	1
doxazosin	1	aromatic amine; benzodioxine; monocarboxylic acid amide; N-acylpiperazine; N-arylpiperazine; quinazolines	alpha-adrenergic antagonist; antihyperplasia drug; antihypertensive agent; antineoplastic agent; vasodilator agent	2023	2023	1.0	low	0	0	1
ebselen	1	benzoselenazole	anti-inflammatory drug; antibacterial agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antioxidant; apoptosis inducer; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; EC 3.5.4.1 (cytosine deaminase) inhibitor; EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor; enzyme mimic; ferroptosis inhibitor; genotoxin; hepatoprotective agent; neuroprotective agent; radical scavenger	2023	2023	1.0	low	0	0	1
etidronate	1	1,1-bis(phosphonic acid)	antineoplastic agent; bone density conservation agent; chelator	2023	2023	1.0	low	0	0	1
2-hexyloxybenzamide	1	aromatic ether; benzamides	antifungal agent	2023	2023	1.0	low	0	0	1
brl 42810	1	2-aminopurines; acetate ester	antiviral drug; prodrug	2023	2023	1.0	low	0	0	1
fluphenazine	1	N-alkylpiperazine; organofluorine compound; phenothiazines	anticoronaviral agent; dopaminergic antagonist; phenothiazine antipsychotic drug	2023	2023	1.0	low	0	0	1
fluorouracil	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic	2023	2023	1.0	low	0	0	1
furosemide	1	chlorobenzoic acid; furans; sulfonamide	environmental contaminant; loop diuretic; xenobiotic	2013	2013	11.0	low	0	1	0
gabexate	1	benzoate ester		2023	2023	1.0	low	0	0	1
glutaral	1	dialdehyde	cross-linking reagent; disinfectant; fixative	2023	2023	1.0	low	0	0	1
gossypol	1			2013	2013	11.0	low	0	1	0
fasudil	2	isoquinolines; N-sulfonyldiazepane	antihypertensive agent; calcium channel blocker; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; geroprotector; neuroprotective agent; nootropic agent; vasodilator agent	2013	2023	6.0	low	0	1	1
haloperidol	1	aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol	antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist	2023	2023	1.0	low	0	0	1
miltefosine	1	phosphocholines; phospholipid	anti-inflammatory agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antiprotozoal drug; apoptosis inducer; immunomodulator; protein kinase inhibitor	2023	2023	1.0	low	0	0	1
hexylresorcinol	1	resorcinols		2023	2023	1.0	low	0	0	1
beta-thujaplicin	1	cyclic ketone; enol; monoterpenoid	antibacterial agent; antifungal agent; antineoplastic agent; antiplasmodial drug; plant metabolite	2023	2023	1.0	low	0	0	1
hycanthone	1	thioxanthenes	mutagen; schistosomicide drug	2023	2023	1.0	low	0	0	1
hydrochlorothiazide	1	benzothiadiazine; organochlorine compound; sulfonamide	antihypertensive agent; diuretic; environmental contaminant; xenobiotic	2023	2023	1.0	low	0	0	1
hydroxyurea	1	one-carbon compound; ureas	antimetabolite; antimitotic; antineoplastic agent; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; genotoxin; immunomodulator; radical scavenger; teratogenic agent	2023	2023	1.0	low	0	0	1
ibuprofen	1	monocarboxylic acid	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; environmental contaminant; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; radical scavenger; xenobiotic	2023	2023	1.0	low	0	0	1
indirubin-3'-monoxime	1			2013	2013	11.0	low	0	1	0
indomethacin	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic	2023	2023	1.0	low	0	0	1
avapro	1	azaspiro compound; biphenylyltetrazole	angiotensin receptor antagonist; antihypertensive agent; environmental contaminant; xenobiotic	2023	2023	1.0	low	0	0	1
itraconazole	1	piperazines		2023	2023	1.0	low	0	0	1
kojic acid	1	4-pyranones; enol; primary alcohol	Aspergillus metabolite; EC 1.10.3.1 (catechol oxidase) inhibitor; EC 1.10.3.2 (laccase) inhibitor; EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor; EC 1.14.18.1 (tyrosinase) inhibitor; EC 1.4.3.3 (D-amino-acid oxidase) inhibitor; NF-kappaB inhibitor; skin lightening agent	2023	2023	1.0	low	0	0	1
lapachol	1			2023	2023	1.0	low	0	0	1
leflunomide	1	(trifluoromethyl)benzenes; isoxazoles; monocarboxylic acid amide	antineoplastic agent; antiparasitic agent; EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; hepatotoxic agent; immunosuppressive agent; non-steroidal anti-inflammatory drug; prodrug; pyrimidine synthesis inhibitor; tyrosine kinase inhibitor	2013	2013	11.0	low	0	1	0
letrozole	1	nitrile; triazoles	antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor	2013	2013	11.0	low	0	1	0
lg 100268	1			2013	2013	11.0	low	0	1	0
loperamide	1	monocarboxylic acid amide; monochlorobenzenes; piperidines; tertiary alcohol	anticoronaviral agent; antidiarrhoeal drug; mu-opioid receptor agonist	2023	2023	1.0	low	0	0	1
loratadine	1	benzocycloheptapyridine; ethyl ester; N-acylpiperidine; organochlorine compound; tertiary carboxamide	anti-allergic agent; cholinergic antagonist; geroprotector; H1-receptor antagonist	2023	2023	1.0	low	0	0	1
losartan	1	biphenylyltetrazole; imidazoles	angiotensin receptor antagonist; anti-arrhythmia drug; antihypertensive agent; endothelin receptor antagonist	2023	2023	1.0	low	0	0	1
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamide	2	benzamides; hydroxamic acid; secondary carboxamide; tertiary amino compound	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	2017	2023	4.0	medium	0	1	1
mafenide	1	aromatic amine		2023	2023	1.0	low	0	0	1
metformin	1	guanidines	environmental contaminant; geroprotector; hypoglycemic agent; xenobiotic	2013	2013	11.0	low	0	1	0
methazolamide	1	sulfonamide; thiadiazoles		2023	2023	1.0	low	0	0	1
methocarbamol	1	aromatic ether; carbamate ester; secondary alcohol		2023	2023	1.0	low	0	0	1
mitoxantrone	2	dihydroxyanthraquinone	analgesic; antineoplastic agent	2013	2023	6.0	low	0	1	1
entinostat	10	benzamides; carbamate ester; primary amino compound; pyridines; substituted aniline	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	2008	2023	10.2	low	3	6	1
ethylmaleimide	1	maleimides	anticoronaviral agent; EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor; EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor; EC 2.7.1.1 (hexokinase) inhibitor	2023	2023	1.0	low	0	0	1
nabumetone	1	methoxynaphthalene; methyl ketone	cyclooxygenase 2 inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug; prodrug	2023	2023	1.0	low	0	0	1
nafamostat	1	benzoic acids; guanidines		2023	2023	1.0	low	0	0	1
nevirapine	1	cyclopropanes; dipyridodiazepine	antiviral drug; HIV-1 reverse transcriptase inhibitor	2023	2023	1.0	low	0	0	1
olprinone	1	bipyridines		2013	2013	11.0	low	0	1	0
omeprazole	2	aromatic ether; benzimidazoles; pyridines; sulfoxide		2013	2023	6.0	low	0	1	1
osalmide	1	organic molecular entity		2023	2023	1.0	low	0	0	1
oxethazaine	1	amino acid amide		2023	2023	1.0	low	0	0	1
palmidrol	1	endocannabinoid; N-(long-chain-acyl)ethanolamine; N-(saturated fatty acyl)ethanolamine	anti-inflammatory drug; anticonvulsant; antihypertensive agent; neuroprotective agent	2023	2023	1.0	low	0	0	1
papaverine	1	benzylisoquinoline alkaloid; dimethoxybenzene; isoquinolines	antispasmodic drug; vasodilator agent	2023	2023	1.0	low	0	0	1
pentoxifylline	1	oxopurine		2023	2023	1.0	low	0	0	1
perhexiline	1	piperidines	cardiovascular drug	2023	2023	1.0	low	0	0	1
phenazopyridine	1	diaminopyridine; monoazo compound	anticoronaviral agent; carcinogenic agent; local anaesthetic; non-narcotic analgesic	2023	2023	1.0	low	0	0	1
4-phenylbutyric acid	1	monocarboxylic acid	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor; prodrug	2023	2023	1.0	low	0	0	1
phenylmethylsulfonyl fluoride	1	acyl fluoride	serine proteinase inhibitor	2023	2023	1.0	low	0	0	1
pimobendan	1	benzimidazoles; pyridazinone	cardiotonic drug; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; vasodilator agent	2023	2023	1.0	low	0	0	1
pioglitazone	1	aromatic ether; pyridines; thiazolidinediones	antidepressant; cardioprotective agent; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; geroprotector; hypoglycemic agent; insulin-sensitizing drug; PPARgamma agonist; xenobiotic	2013	2013	11.0	low	0	1	0
pj-34	1	phenanthridines; secondary carboxamide; tertiary amino compound	angiogenesis inhibitor; anti-inflammatory agent; antiatherosclerotic agent; antineoplastic agent; apoptosis inducer; cardioprotective agent; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; neuroprotective agent	2023	2023	1.0	low	0	0	1
praziquantel	1	isoquinolines		2023	2023	1.0	low	0	0	1
probenecid	1	benzoic acids; sulfonamide	uricosuric drug	2023	2023	1.0	low	0	0	1
probucol	1	dithioketal; polyphenol	anti-inflammatory drug; anticholesteremic drug; antilipemic drug; antioxidant; cardiovascular drug	2023	2023	1.0	low	0	0	1
promazine	1	phenothiazines; tertiary amine	antiemetic; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; H1-receptor antagonist; muscarinic antagonist; phenothiazine antipsychotic drug; serotonergic antagonist	2023	2023	1.0	low	0	0	1
promethazine	1	phenothiazines; tertiary amine	anti-allergic agent; anticoronaviral agent; antiemetic; antipruritic drug; H1-receptor antagonist; local anaesthetic; sedative	2023	2023	1.0	low	0	0	1
propranolol	1	naphthalenes; propanolamine; secondary amine	anti-arrhythmia drug; antihypertensive agent; anxiolytic drug; beta-adrenergic antagonist; environmental contaminant; human blood serum metabolite; vasodilator agent; xenobiotic	2023	2023	1.0	low	0	0	1
pyroxamide	1	aromatic amide		2010	2010	14.0	low	1	0	0
3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one	1	indoles		2013	2013	11.0	low	0	1	0
riluzole	1	benzothiazoles		2013	2013	11.0	low	0	1	0
rimantadine	1	alkylamine		2023	2023	1.0	low	0	0	1
rolipram	1	pyrrolidin-2-ones	antidepressant; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor	2023	2023	1.0	low	0	0	1
sb 206553	1	pyrroloindole		2013	2013	11.0	low	0	1	0
sb 220025	1	aminopyrimidine; imidazoles; organofluorine compound; piperidines	angiogenesis inhibitor; anti-inflammatory agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	2013	2013	11.0	low	0	1	0
sb 202190	1	imidazoles; organofluorine compound; phenols; pyridines	apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	2013	2013	11.0	low	0	1	0
suberoyl bis-hydroxamic acid	1	hydroxamic acid		2010	2010	14.0	low	1	0	0
scriptaid	3	isoquinolines		2010	2023	7.3	low	1	1	1
sebacic acid	1	alpha,omega-dicarboxylic acid; dicarboxylic fatty acid	human metabolite; plant metabolite	2023	2023	1.0	low	0	0	1
sk&f 86002	1	imidazoles		2013	2013	11.0	low	0	1	0
fenofibrate	1	benzochromenone; delta-lactone; naphtho-alpha-pyrone	platelet aggregation inhibitor; Sir2 inhibitor	2023	2023	1.0	low	0	0	1
imatinib	2	aromatic amine; benzamides; N-methylpiperazine; pyridines; pyrimidines	antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor	2013	2023	6.0	low	0	1	1
vorinostat	14	dicarboxylic acid diamide; hydroxamic acid	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	2008	2022	11.1	low	5	8	1
sulfasalazine	1			2013	2013	11.0	low	0	1	0
suprofen	1	aromatic ketone; monocarboxylic acid; thiophenes	antirheumatic drug; drug allergen; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug; peripheral nervous system drug	2023	2023	1.0	low	0	0	1
2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethylethanamine	1	stilbenoid		2013	2013	11.0	low	0	1	0
thalidomide	1	phthalimides; piperidones		2023	2023	1.0	low	0	0	1
ticlopidine	1	monochlorobenzenes; thienopyridine	anticoagulant; fibrin modulating drug; hematologic agent; P2Y12 receptor antagonist; platelet aggregation inhibitor	2023	2023	1.0	low	0	0	1
triamterene	1	pteridines	diuretic; sodium channel blocker	2023	2023	1.0	low	0	0	1
trifluoperazine	1	N-alkylpiperazine; N-methylpiperazine; organofluorine compound; phenothiazines	antiemetic; calmodulin antagonist; dopaminergic antagonist; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor; phenothiazine antipsychotic drug	2023	2023	1.0	low	0	0	1
triflupromazine	1	organofluorine compound; phenothiazines; tertiary amine	anticoronaviral agent; antiemetic; dopaminergic antagonist; first generation antipsychotic	2023	2023	1.0	low	0	0	1
trigonelline	1	alkaloid; iminium betaine	food component; human urinary metabolite; plant metabolite	2023	2023	1.0	low	0	0	1
trimethobenzamide	1	benzamides; tertiary amino compound	antiemetic	2023	2023	1.0	low	0	0	1
trimethoprim	1	aminopyrimidine; methoxybenzenes	antibacterial drug; diuretic; drug allergen; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; environmental contaminant; xenobiotic	2023	2023	1.0	low	0	0	1
troglitazone	1	chromanes; thiazolidinone	anticoagulant; anticonvulsant; antineoplastic agent; antioxidant; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; hypoglycemic agent; platelet aggregation inhibitor; vasodilator agent	2013	2013	11.0	low	0	1	0
tyrphostin a9	1	alkylbenzene	geroprotector	2023	2023	1.0	low	0	0	1
delavirdine	1	aminopyridine; indolecarboxamide; N-acylpiperazine; sulfonamide	antiviral drug; HIV-1 reverse transcriptase inhibitor	2023	2023	1.0	low	0	0	1
vesnarinone	1	organic molecular entity		2023	2023	1.0	low	0	0	1
idoxuridine	1	organoiodine compound; pyrimidine 2'-deoxyribonucleoside	antiviral drug; DNA synthesis inhibitor	2023	2023	1.0	low	0	0	1
chloramphenicol	1	C-nitro compound; carboxamide; diol; organochlorine compound	antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor	2023	2023	1.0	low	0	0	1
lysine	1	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite	2023	2023	1.0	low	0	0	1
phenylethyl alcohol	1	benzenes; primary alcohol	Aspergillus metabolite; fragrance; plant growth retardant; plant metabolite; Saccharomyces cerevisiae metabolite	2023	2023	1.0	low	0	0	1
zoxazolamine	1	benzoxazole		2023	2023	1.0	low	0	0	1
colchicine	1	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen	2015	2015	9.0	low	0	1	0
cycloheximide	1	antibiotic fungicide; cyclic ketone; dicarboximide; piperidine antibiotic; piperidones; secondary alcohol	anticoronaviral agent; bacterial metabolite; ferroptosis inhibitor; neuroprotective agent; protein synthesis inhibitor	2023	2023	1.0	low	0	0	1
ficusin	1	psoralens	plant metabolite	2023	2023	1.0	low	0	0	1
tubercidin	1	antibiotic antifungal agent; N-glycosylpyrrolopyrimidine; ribonucleoside	antimetabolite; antineoplastic agent; bacterial metabolite	2023	2023	1.0	low	0	0	1
trifluridine	1	nucleoside analogue; organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; EC 2.1.1.45 (thymidylate synthase) inhibitor	2023	2023	1.0	low	0	0	1
9,10-anthraquinone	1	anthraquinone		2023	2023	1.0	low	0	0	1
salicylanilide	1	benzanilide fungicide; salicylamides; salicylanilides		2023	2023	1.0	low	0	0	1
gramine	1	aminoalkylindole; indole alkaloid; tertiary amino compound	antibacterial agent; antiviral agent; plant metabolite; serotonergic antagonist	2023	2023	1.0	low	0	0	1
aminacrine	1	aminoacridines; primary amino compound	acid-base indicator; antiinfective agent; antiseptic drug; fluorescent dye; MALDI matrix material; mutagen	2023	2023	1.0	low	0	0	1
methyl gallate	1	gallate ester	anti-inflammatory agent; antioxidant; plant metabolite	2023	2023	1.0	low	0	0	1
monobenzone	1	benzyl ether	allergen; dermatologic drug; melanin synthesis inhibitor	2023	2023	1.0	low	0	0	1
ditiocarb	1	dithiocarbamic acids	chelator; copper chelator	2023	2023	1.0	low	0	0	1
catechin	1	catechin	antioxidant; plant metabolite	2023	2023	1.0	low	0	0	1
azacitidine	2	N-glycosyl-1,3,5-triazine; nucleoside analogue	antineoplastic agent	2013	2023	6.0	low	0	1	1
lucanthone	1	thioxanthenes	adjuvant; antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; mutagen; photosensitizing agent; prodrug; schistosomicide drug	2023	2023	1.0	low	0	0	1
cepharanthine	1	bisbenzylisoquinoline alkaloid; isoquinolines		2023	2023	1.0	low	0	0	1
aloe emodin	1	aromatic primary alcohol; dihydroxyanthraquinone	antineoplastic agent; plant metabolite	2023	2023	1.0	low	0	0	1
chrysophanic acid	1	dihydroxyanthraquinone	anti-inflammatory agent; antiviral agent; plant metabolite	2023	2023	1.0	low	0	0	1
emetine	1	isoquinoline alkaloid; pyridoisoquinoline	antiamoebic agent; anticoronaviral agent; antiinfective agent; antimalarial; antineoplastic agent; antiprotozoal drug; antiviral agent; autophagy inhibitor; emetic; expectorant; plant metabolite; protein synthesis inhibitor	2023	2023	1.0	low	0	0	1
osthol	1	botanical anti-fungal agent; coumarins	metabolite	2023	2023	1.0	low	0	0	1
flavanone	1	flavanones		2023	2023	1.0	low	0	0	1
phloretic acid	1	hydroxy monocarboxylic acid	plant metabolite	2023	2023	1.0	low	0	0	1
oleanolic acid	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite	2023	2023	1.0	low	0	0	1
podophyllotoxin	1	furonaphthodioxole; lignan; organic heterotetracyclic compound	antimitotic; antineoplastic agent; keratolytic drug; microtubule-destabilising agent; plant metabolite; tubulin modulator	2013	2013	11.0	low	0	1	0
angelicin	1	furanocoumarin		2023	2023	1.0	low	0	0	1
diperodon	1	carbamate ester		2023	2023	1.0	low	0	0	1
formestane	1	17-oxo steroid; 3-oxo-Delta(4) steroid; enol; hydroxy steroid	antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor	2013	2013	11.0	low	0	1	0
megestrol acetate	1	20-oxo steroid; 3-oxo-Delta(4) steroid; acetate ester; steroid ester	antineoplastic agent; appetite enhancer; contraceptive drug; progestin; synthetic oral contraceptive	2023	2023	1.0	low	0	0	1
acetylcysteine	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary	2023	2023	1.0	low	0	0	1
hydroxychloroquine sulfate	2			2013	2023	6.0	medium	0	1	1
ethambutol	1	ethanolamines; ethylenediamine derivative	antitubercular agent; environmental contaminant; xenobiotic	2023	2023	1.0	low	0	0	1
metformin hydrochloride	1	hydrochloride	environmental contaminant; hypoglycemic agent; xenobiotic	2023	2023	1.0	low	0	0	1
antimycin a	1	benzamides; formamides; macrodiolide; phenols	antifungal agent; mitochondrial respiratory-chain inhibitor; piscicide	2023	2023	1.0	low	0	0	1
5,5'-dimethyl-2,2'-bipyridyl	1	bipyridines		2023	2023	1.0	medium	0	0	1
dichlorobenzyl alcohol	1	benzyl alcohols; dichlorobenzene	antiseptic drug	2023	2023	1.0	low	0	0	1
amiloride hydrochloride, anhydrous	1	hydrochloride	diuretic; sodium channel blocker	2013	2013	11.0	low	0	1	0
acadesine	1	1-ribosylimidazolecarboxamide; aminoimidazole; nucleoside analogue	antineoplastic agent; platelet aggregation inhibitor	2013	2013	11.0	low	0	1	0
stavudine	1	dihydrofuran; nucleoside analogue; organic molecular entity	antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor	2023	2023	1.0	low	0	0	1
dideoxyadenosine	1	adenosines; purine 2',3'-dideoxyribonucleoside	EC 3.5.4.4 (adenosine deaminase) inhibitor; EC 4.6.1.1 (adenylate cyclase) inhibitor	2023	2023	1.0	low	0	0	1
cladribine	1	organochlorine compound; purine 2'-deoxyribonucleoside	antineoplastic agent; immunosuppressive agent	2013	2013	11.0	low	0	1	0
vidarabine	1	beta-D-arabinoside; purine nucleoside	antineoplastic agent; bacterial metabolite; nucleoside antibiotic	2023	2023	1.0	low	0	0	1
3-deazaadenosine	1			2023	2023	1.0	low	0	0	1
zalcitabine	1	pyrimidine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor	2023	2023	1.0	low	0	0	1
ancitabine	1	diol; organic heterotricyclic compound	antimetabolite; antineoplastic agent; prodrug	2023	2023	1.0	low	0	0	1
chloropyramine	1	aminopyridine		2023	2023	1.0	low	0	0	1
levamisole	1	6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole	antinematodal drug; antirheumatic drug; EC 3.1.3.1 (alkaline phosphatase) inhibitor; immunological adjuvant; immunomodulator	2023	2023	1.0	low	0	0	1
n'-nitrosonornicotine	1	pyridines; pyrrolidines		2023	2023	1.0	low	0	0	1
daunorubicin	1	aminoglycoside antibiotic; anthracycline; p-quinones; tetracenequinones	antineoplastic agent; bacterial metabolite	2023	2023	1.0	low	0	0	1
zidovudine	2	azide; pyrimidine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor	2013	2023	6.0	low	0	1	1
etoposide	1	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor	2013	2013	11.0	low	0	1	0
ribavirin	1	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide	anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor	2023	2023	1.0	low	0	0	1
pyridoxal phosphate	1	pyridinecarbaldehyde		2023	2023	1.0	medium	0	0	1
lonidamine	1	dichlorobenzene; indazoles; monocarboxylic acid	antineoplastic agent; antispermatogenic agent; EC 2.7.1.1 (hexokinase) inhibitor; geroprotector	2013	2013	11.0	low	0	1	0
nitazoxanide	1	benzamides; carboxylic ester		2023	2023	1.0	low	0	0	1
captopril	1	alkanethiol; L-proline derivative; N-acylpyrrolidine; pyrrolidinemonocarboxylic acid	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor	2023	2023	1.0	low	0	0	1
oltipraz	1	1,2-dithiole; pyrazines	angiogenesis modulating agent; antimutagen; antineoplastic agent; antioxidant; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor; neurotoxin; protective agent; schistosomicide drug	2023	2023	1.0	low	0	0	1
fiacitabine	1			2023	2023	1.0	low	0	0	1
simvastatin	1	delta-lactone; fatty acid ester; hexahydronaphthalenes; statin (semi-synthetic)	EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor; EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor; ferroptosis inducer; geroprotector; prodrug	2013	2013	11.0	low	0	1	0
itraconazole	1	aromatic ether; conazole antifungal drug; cyclic ketal; dichlorobenzene; dioxolane; N-arylpiperazine; triazole antifungal drug; triazoles	EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor; Hedgehog signaling pathway inhibitor; P450 inhibitor	2013	2013	11.0	low	0	1	0
pravadoline	1			2013	2013	11.0	low	0	1	0
ranolazine	1	aromatic amide; monocarboxylic acid amide; monomethoxybenzene; N-alkylpiperazine; secondary alcohol		2023	2023	1.0	low	0	0	1
brequinar	1	biphenyls; monocarboxylic acid; monofluorobenzenes; quinolinemonocarboxylic acid	anticoronaviral agent; antimetabolite; antineoplastic agent; antiviral agent; EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor; immunosuppressive agent; pyrimidine synthesis inhibitor	2023	2023	1.0	low	0	0	1
imiquimod	1	imidazoquinoline	antineoplastic agent; interferon inducer	2023	2023	1.0	low	0	0	1
adefovir	1	6-aminopurines; ether; phosphonic acids	antiviral drug; DNA synthesis inhibitor; drug metabolite; HIV-1 reverse transcriptase inhibitor; nephrotoxic agent	2023	2023	1.0	low	0	0	1
zileuton	1	1-benzothiophenes; ureas	anti-asthmatic drug; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; ferroptosis inhibitor; leukotriene antagonist; non-steroidal anti-inflammatory drug	2013	2013	11.0	low	0	1	0
niguldipine	1	diarylmethane		2013	2013	11.0	low	0	1	0
cidofovir anhydrous	1	phosphonic acids; pyrimidone	anti-HIV agent; antineoplastic agent; antiviral drug; photosensitizing agent	2023	2023	1.0	low	0	0	1
topotecan	1	pyranoindolizinoquinoline	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor	2013	2013	11.0	low	0	1	0
eliprodil	1	monochlorobenzenes; monofluorobenzenes; piperidines; secondary alcohol; tertiary amino compound		2013	2013	11.0	low	0	1	0
celgosivir	1			2023	2023	1.0	low	0	0	1
gemcitabine	2	organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; environmental contaminant; immunosuppressive agent; photosensitizing agent; prodrug; radiosensitizing agent; xenobiotic	2013	2023	6.0	low	0	1	1
lamivudine	1	monothioacetal; nucleoside analogue; oxacycle; primary alcohol	allergen; anti-HBV agent; antiviral drug; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor; HIV-1 reverse transcriptase inhibitor; prodrug	2023	2023	1.0	low	0	0	1
valsartan	1	biphenylyltetrazole; monocarboxylic acid amide; monocarboxylic acid	angiotensin receptor antagonist; antihypertensive agent; environmental contaminant; xenobiotic	2023	2023	1.0	low	0	0	1
zanamivir	1	guanidines	antiviral agent; EC 3.2.1.18 (exo-alpha-sialidase) inhibitor	2023	2023	1.0	low	0	0	1
adefovir dipivoxil	1	6-aminopurines; carbonate ester; ether; organic phosphonate	antiviral drug; DNA synthesis inhibitor; HIV-1 reverse transcriptase inhibitor; nephrotoxic agent; prodrug	2023	2023	1.0	low	0	0	1
emtricitabine	1	monothioacetal; nucleoside analogue; organofluorine compound; pyrimidone	antiviral drug; HIV-1 reverse transcriptase inhibitor	2023	2023	1.0	low	0	0	1
octyl gallate	1	gallate ester	food antioxidant; hypoglycemic agent; plant metabolite	2023	2023	1.0	low	0	0	1
verapamil hydrochloride	1			2013	2013	11.0	low	0	1	0
efavirenz	2	acetylenic compound; benzoxazine; cyclopropanes; organochlorine compound; organofluorine compound	antiviral drug; HIV-1 reverse transcriptase inhibitor	2013	2023	6.0	low	0	1	1
nelfinavir	1	aryl sulfide; benzamides; organic heterobicyclic compound; phenols; secondary alcohol; tertiary amino compound	antineoplastic agent; HIV protease inhibitor	2023	2023	1.0	low	0	0	1
betulinic acid	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	anti-HIV agent; anti-inflammatory agent; antimalarial; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; plant metabolite	2023	2023	1.0	low	0	0	1
arctigenin	1	lignan		2023	2023	1.0	low	0	0	1
baicalin	1	dihydroxyflavone; glucosiduronic acid; glycosyloxyflavone; monosaccharide derivative	antiatherosclerotic agent; antibacterial agent; anticoronaviral agent; antineoplastic agent; antioxidant; cardioprotective agent; EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; ferroptosis inhibitor; neuroprotective agent; non-steroidal anti-inflammatory drug; plant metabolite; prodrug	2023	2023	1.0	low	0	0	1
plerixafor	1	azacycloalkane; azamacrocycle; benzenes; crown amine; secondary amino compound; tertiary amino compound	anti-HIV agent; antineoplastic agent; C-X-C chemokine receptor type 4 antagonist; immunological adjuvant	2023	2023	1.0	low	0	0	1
amprenavir	1	carbamate ester; sulfonamide; tetrahydrofuryl ester	antiviral drug; HIV protease inhibitor	2023	2023	1.0	low	0	0	1
oseltamivir	1	acetamides; amino acid ester; cyclohexenecarboxylate ester; primary amino compound	antiviral drug; EC 3.2.1.18 (exo-alpha-sialidase) inhibitor; environmental contaminant; prodrug; xenobiotic	2023	2023	1.0	low	0	0	1
epigallocatechin gallate	1	flavans; gallate ester; polyphenol	antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite	2023	2023	1.0	low	0	0	1
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose	1	gallate ester; galloyl beta-D-glucose	anti-inflammatory agent; antineoplastic agent; geroprotector; hepatoprotective agent; plant metabolite; radiation protective agent; radical scavenger	2023	2023	1.0	low	0	0	1
cephalotaxine	1	benzazepine alkaloid fundamental parent; benzazepine alkaloid; cyclic acetal; enol ether; organic heteropentacyclic compound; secondary alcohol; tertiary amino compound		2023	2023	1.0	medium	0	0	1
desipramine hydrochloride	1	hydrochloride	drug allergen	2023	2023	1.0	low	0	0	1
mefloquine hydrochloride	1	hydrochloride		2023	2023	1.0	low	0	0	1
bendamustine	1	benzimidazoles		2013	2013	11.0	low	0	1	0
aloxistatin	1	epoxide; ethyl ester; L-leucine derivative; monocarboxylic acid amide	anticoronaviral agent; cathepsin B inhibitor	2023	2023	1.0	low	0	0	1
propazole	1	benzimidazoles		2023	2023	1.0	low	0	0	1
caroverine	1	quinoxaline derivative		2013	2013	11.0	low	0	1	0
cgs 9343b	1	benzimidazoles		2013	2013	11.0	low	0	1	0
prulifloxacin	1	fluoroquinolone antibiotic; quinolone antibiotic		2023	2023	1.0	low	0	0	1
telmisartan	2	benzimidazoles; biphenyls; carboxybiphenyl	angiotensin receptor antagonist; antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; environmental contaminant; xenobiotic	2013	2023	6.0	low	0	1	1
bergenin	1	trihydroxybenzoic acid	metabolite	2023	2023	1.0	low	0	0	1
2-methoxyestradiol	1	17beta-hydroxy steroid; 3-hydroxy steroid	angiogenesis modulating agent; antimitotic; antineoplastic agent; human metabolite; metabolite; mouse metabolite	2013	2013	11.0	low	0	1	0
zoledronic acid	1	1,1-bis(phosphonic acid); imidazoles	bone density conservation agent	2023	2023	1.0	low	0	0	1
artemisinin	1	organic peroxide; sesquiterpene lactone	antimalarial; plant metabolite	2023	2023	1.0	low	0	0	1
brinzolamide	1	sulfonamide; thienothiazine	antiglaucoma drug; EC 4.2.1.1 (carbonic anhydrase) inhibitor	2023	2023	1.0	low	0	0	1
dipropylacetamide	1	fatty amide	geroprotector; metabolite; teratogenic agent	2023	2023	1.0	low	0	0	1
oxprenolol hydrochloride	1			2023	2023	1.0	low	0	0	1
opipramol hydrochloride	1			2023	2023	1.0	low	0	0	1
moroxydine	1	biguanides		2023	2023	1.0	low	0	0	1
alacepril	1	dipeptide; thioacetate ester	EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor	2013	2013	11.0	low	0	1	0
thioxolone	1	benzoxathiole	antiseborrheic	2023	2023	1.0	low	0	0	1
ubenimex	2			2013	2017	9.0	low	0	2	0
honokiol	1	biphenyls		2023	2023	1.0	low	0	0	1
nobiletin	1	methoxyflavone	antineoplastic agent; plant metabolite	2023	2023	1.0	low	0	0	1
lycorine	1	indolizidine alkaloid	anticoronaviral agent; antimalarial; plant metabolite; protein synthesis inhibitor	2023	2023	1.0	low	0	0	1
leupeptin	1	aldehyde; tripeptide	bacterial metabolite; calpain inhibitor; cathepsin B inhibitor; EC 3.4.21.4 (trypsin) inhibitor; serine protease inhibitor	2023	2023	1.0	low	0	0	1
tetrandrine	1	bisbenzylisoquinoline alkaloid; isoquinolines		2023	2023	1.0	low	0	0	1
calpeptin	1	amino acid amide		2023	2023	1.0	low	0	0	1
fangchinoline	1	aromatic ether; bisbenzylisoquinoline alkaloid; macrocycle	anti-HIV-1 agent; anti-inflammatory agent; antineoplastic agent; antioxidant; neuroprotective agent; plant metabolite	2023	2023	1.0	low	0	0	1
maslinic acid	1	dihydroxy monocarboxylic acid; pentacyclic triterpenoid	anti-inflammatory agent; antineoplastic agent; antioxidant; plant metabolite	2023	2023	1.0	low	0	0	1
atovaquone	1	hydroxy-1,2-naphthoquinone		2023	2023	1.0	low	0	0	1
loganin	1	beta-D-glucoside; cyclopentapyran; enoate ester; iridoid monoterpenoid; methyl ester; monosaccharide derivative; secondary alcohol	anti-inflammatory agent; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; EC 3.4.23.46 (memapsin 2) inhibitor; neuroprotective agent; plant metabolite	2023	2023	1.0	low	0	0	1
moexipril	1	peptide		2023	2023	1.0	low	0	0	1
aucubin	1	organic molecular entity	metabolite	2023	2023	1.0	low	0	0	1
catalpol	1	organic molecular entity	metabolite	2023	2023	1.0	low	0	0	1
lekoptin	1	2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile		2023	2023	1.0	low	0	0	1
n-methyladenosine	1	methyladenosine		2023	2023	1.0	low	0	0	1
vinpocetine	1			2013	2013	11.0	medium	0	1	0
sivelestat	1	N-acylglycine; pivalate ester		2023	2023	1.0	low	0	0	1
pyronaridine	1	aminoquinoline		2023	2023	1.0	low	0	0	1
geniposide	1	terpene glycoside		2023	2023	1.0	low	0	0	1
deguelin	1	aromatic ether; diether; organic heteropentacyclic compound; rotenones	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; antiviral agent; apoptosis inducer; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; mitochondrial NADH:ubiquinone reductase inhibitor; plant metabolite	2013	2013	11.0	low	0	1	0
daidzin	1	7-hydroxyisoflavones 7-O-beta-D-glucoside; hydroxyisoflavone; monosaccharide derivative	plant metabolite	2023	2023	1.0	low	0	0	1
triptolide	1	diterpenoid; epoxide; gamma-lactam; organic heteroheptacyclic compound	antispermatogenic agent; plant metabolite	2013	2013	11.0	low	0	1	0
sophocarpine	1			2023	2023	1.0	low	0	0	1
marimastat	1	hydroxamic acid; secondary carboxamide	antineoplastic agent; matrix metalloproteinase inhibitor	2023	2023	1.0	low	0	0	1
sr 48692	1	N-acyl-amino acid		2013	2013	11.0	low	0	1	0
elacridar	2			2013	2023	6.0	low	0	1	1
celastrol	1	monocarboxylic acid; pentacyclic triterpenoid	anti-inflammatory drug; antineoplastic agent; antioxidant; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Hsp90 inhibitor; metabolite	2023	2023	1.0	low	0	0	1
gefitinib	1	aromatic ether; monochlorobenzenes; monofluorobenzenes; morpholines; quinazolines; secondary amino compound; tertiary amino compound	antineoplastic agent; epidermal growth factor receptor antagonist	2013	2013	11.0	low	0	1	0
n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine	1	leucine derivative		2023	2023	1.0	low	0	0	1
bay x 1005	1			2013	2013	11.0	low	0	1	0
vadimezan	1	monocarboxylic acid; xanthones	antineoplastic agent	2023	2023	1.0	low	0	0	1
e 64	1	dicarboxylic acid monoamide; epoxy monocarboxylic acid; guanidines; L-leucine derivative; zwitterion	antimalarial; antiparasitic agent; protease inhibitor	2023	2023	1.0	low	0	0	1
gyki 53655	1			2013	2013	11.0	low	0	1	0
umifenovir	1	indolyl carboxylic acid		2023	2023	1.0	low	0	0	1
safinamide	1	amino acid amide		2023	2023	1.0	low	0	0	1
ilomastat	1	hydroxamic acid; L-tryptophan derivative; N-acyl-amino acid	anti-inflammatory agent; antibacterial agent; antineoplastic agent; EC 3.4.24.24 (gelatinase A) inhibitor; neuroprotective agent	2023	2023	1.0	low	0	0	1
ml-3000	1			2013	2013	11.0	low	0	1	0
cd 437	1	adamantanes; monocarboxylic acid; naphthoic acid; phenols	apoptosis inducer; retinoic acid receptor gamma agonist	2013	2013	11.0	low	0	1	0
docetaxel anhydrous	1	secondary alpha-hydroxy ketone; tetracyclic diterpenoid	antimalarial; antineoplastic agent; photosensitizing agent	2013	2013	11.0	low	0	1	0
perifosine	1	ammonium betaine; phospholipid	EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor	2013	2013	11.0	low	0	1	0
atazanavir	1	carbohydrazide	antiviral drug; HIV protease inhibitor	2023	2023	1.0	low	0	0	1
mk 767	1			2013	2013	11.0	low	0	1	0
vx 497	1			2023	2023	1.0	low	0	0	1
bcx 1812	1	3-hydroxy monocarboxylic acid; acetamides; cyclopentanols; guanidines	antiviral drug; EC 3.2.1.18 (exo-alpha-sialidase) inhibitor	2023	2023	1.0	low	0	0	1
bazedoxifene acetate	1			2013	2013	11.0	medium	0	1	0
naproxen	1	methoxynaphthalene; monocarboxylic acid	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; environmental contaminant; gout suppressant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic	2023	2023	1.0	low	0	0	1
canertinib	1	monochlorobenzenes; morpholines; organofluorine compound; quinazolines	antineoplastic agent; tyrosine kinase inhibitor	2013	2013	11.0	low	0	1	0
birb 796	1	aromatic ether; morpholines; naphthalenes; pyrazoles; ureas	EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; immunomodulator	2013	2013	11.0	low	0	1	0
olmesartan	1	biphenylyltetrazole	angiotensin receptor antagonist; antihypertensive agent	2023	2023	1.0	low	0	0	1
telbivudine	1	pyrimidine 2'-deoxyribonucleoside	antiviral drug; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor	2023	2023	1.0	low	0	0	1
tipifarnib	1	imidazoles; monochlorobenzenes; primary amino compound; quinolone	antineoplastic agent; apoptosis inducer; EC 2.5.1.58 (protein farnesyltransferase) inhibitor	2013	2013	11.0	low	0	1	0
celastrol methyl ester	1	carboxylic ester		2023	2023	1.0	low	0	0	1
resiquimod	1	imidazoquinoline		2023	2023	1.0	low	0	0	1
cyc 202	1	2,6-diaminopurines	antiviral drug; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor	2013	2013	11.0	low	0	1	0
tanshinone ii a	1	abietane diterpenoid		2023	2023	1.0	low	0	0	1
anacardic acid	1	hydroxy monocarboxylic acid; hydroxybenzoic acid	anti-inflammatory agent; antibacterial agent; anticoronaviral agent; apoptosis inducer; EC 2.3.1.48 (histone acetyltransferase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; neuroprotective agent; plant metabolite	2023	2023	1.0	low	0	0	1
migalastat	1	piperidines		2023	2023	1.0	low	0	0	1
sb 203580	1	imidazoles; monofluorobenzenes; pyridines; sulfoxide	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector; Hsp90 inhibitor; neuroprotective agent	2013	2013	11.0	low	0	1	0
enzastaurin	1	indoles; maleimides		2013	2013	11.0	low	0	1	0
erlotinib	2	aromatic ether; quinazolines; secondary amino compound; terminal acetylenic compound	antineoplastic agent; epidermal growth factor receptor antagonist; protein kinase inhibitor	2013	2023	6.0	low	0	1	1
piboserod	1			2013	2013	11.0	low	0	1	0
l 163191	1			2013	2013	11.0	low	0	1	0
limonin	1	epoxide; furans; hexacyclic triterpenoid; lactone; limonoid; organic heterohexacyclic compound	inhibitor; metabolite; volatile oil component	2023	2023	1.0	low	0	0	1
scutellarin	1	glucosiduronic acid; glycosyloxyflavone; monosaccharide derivative; trihydroxyflavone	antineoplastic agent; proteasome inhibitor	2023	2023	1.0	low	0	0	1
bd 1047	1	primary amine		2013	2013	11.0	low	0	1	0
etravirine	1	aminopyrimidine; aromatic ether; dinitrile; organobromine compound	antiviral agent; HIV-1 reverse transcriptase inhibitor	2023	2023	1.0	low	0	0	1
chelidonine	1	alkaloid antibiotic; alkaloid fundamental parent; benzophenanthridine alkaloid		2023	2023	1.0	low	0	0	1
4-n-butylresorcinol	1	resorcinols		2023	2023	1.0	low	0	0	1
lapatinib	1	furans; organochlorine compound; organofluorine compound; quinazolines	antineoplastic agent; tyrosine kinase inhibitor	2013	2013	11.0	low	0	1	0
darunavir	1	carbamate ester; furofuran; sulfonamide	antiviral drug; HIV protease inhibitor	2023	2023	1.0	low	0	0	1
dapivirine	1			2023	2023	1.0	low	0	0	1
sorafenib	1	(trifluoromethyl)benzenes; aromatic ether; monochlorobenzenes; phenylureas; pyridinecarboxamide	angiogenesis inhibitor; anticoronaviral agent; antineoplastic agent; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; ferroptosis inducer; tyrosine kinase inhibitor	2013	2013	11.0	low	0	1	0
lenalidomide	1	aromatic amine; dicarboximide; isoindoles; piperidones	angiogenesis inhibitor; antineoplastic agent; immunomodulator	2013	2013	11.0	low	0	1	0
N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide	1	aminoquinoline		2013	2013	11.0	medium	0	1	0
sr 142806	1			2013	2013	11.0	low	0	1	0
n-hydroxy-2,2-diphenylacetamide	1			2009	2009	15.0	medium	1	0	0
nsc 74859	1	amidobenzoic acid; monohydroxybenzoic acid; tosylate ester	STAT3 inhibitor	2023	2023	1.0	low	0	0	1
berbamine	1	bisbenzylisoquinoline alkaloid; isoquinolines		2023	2023	1.0	low	0	0	1
elesclomol	1	carbohydrazide; thiocarbonyl compound	antineoplastic agent; apoptosis inducer	2013	2013	11.0	low	0	1	0
u-104	1			2023	2023	1.0	low	0	0	1
7-hydroxy-5-methyl-2-(2-oxopropyl)-8-[3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]-1-benzopyran-4-one	1	glycoside		2023	2023	1.0	medium	0	0	1
nsc 663284	1	quinolone		2013	2013	11.0	low	0	1	0
bortezomib	2	amino acid amide; L-phenylalanine derivative; pyrazines	antineoplastic agent; antiprotozoal drug; protease inhibitor; proteasome inhibitor	2013	2023	6.0	low	0	1	1
ritonavir	1	1,3-thiazoles; carbamate ester; carboxamide; L-valine derivative; ureas	antiviral drug; environmental contaminant; HIV protease inhibitor; xenobiotic	2023	2023	1.0	low	0	0	1
tizoxanide	1	salicylamides		2023	2023	1.0	low	0	0	1
bardoxolone methyl	1	cyclohexenones		2013	2013	11.0	low	0	1	0
nsc 23766	1	aminopyrimidine; aminoquinoline; primary amino compound; secondary amino compound; tertiary amino compound	antiviral agent; apoptosis inducer; EC 3.6.5.2 (small monomeric GTPase) inhibitor; muscarinic antagonist	2013	2013	11.0	low	0	1	0
arbutin	1	beta-D-glucoside; monosaccharide derivative	Escherichia coli metabolite; plant metabolite	2023	2023	1.0	low	0	0	1
quinidine	1	cinchona alkaloid	alpha-adrenergic antagonist; anti-arrhythmia drug; antimalarial; drug allergen; EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor; EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor; muscarinic antagonist; P450 inhibitor; potassium channel blocker; sodium channel blocker	2023	2023	1.0	low	0	0	1
conessine	1	steroid alkaloid; tertiary amino compound	antibacterial agent; antimalarial; H3-receptor antagonist; plant metabolite	2023	2023	1.0	low	0	0	1
saquinavir	1	L-asparagine derivative; quinolines	antiviral drug; HIV protease inhibitor	2023	2023	1.0	low	0	0	1
abacavir	1	2,6-diaminopurines	antiviral drug; drug allergen; HIV-1 reverse transcriptase inhibitor	2023	2023	1.0	low	0	0	1
linezolid	1	acetamides; morpholines; organofluorine compound; oxazolidinone	antibacterial drug; protein synthesis inhibitor	2023	2023	1.0	low	0	0	1
cephaelin	1	pyridoisoquinoline		2023	2023	1.0	low	0	0	1
(-)-usnic acid	1	usnic acid	EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor	2023	2023	1.0	medium	0	0	1
acetylleucyl-leucyl-norleucinal	1	aldehyde; tripeptide	cysteine protease inhibitor	2023	2023	1.0	low	0	0	1
trichostatin a	4	antibiotic antifungal agent; hydroxamic acid; trichostatin	bacterial metabolite; EC 3.5.1.98 (histone deacetylase) inhibitor; geroprotector	2008	2017	12.2	low	2	2	0
resveratrol	1	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger	2023	2023	1.0	low	0	0	1
tacrolimus	1	macrolide lactam	bacterial metabolite; immunosuppressive agent	2023	2023	1.0	low	0	0	1
lycopene	1	acyclic carotene	antioxidant; plant metabolite	2023	2023	1.0	low	0	0	1
zithromax	1	macrolide antibiotic	antibacterial drug; environmental contaminant; xenobiotic	2023	2023	1.0	low	0	0	1
gw 3965	1	diarylmethane		2013	2013	11.0	low	0	1	0
y 27632	1	aromatic amide		2013	2013	11.0	low	0	1	0
6-bromoindirubin-3'-oxime	1			2013	2013	11.0	low	0	1	0
purvalanol b	1	purvalanol	protein kinase inhibitor	2013	2013	11.0	low	0	1	0
y-700	1			2013	2013	11.0	low	0	1	0
repsox	1	pyrazolopyridine		2013	2013	11.0	low	0	1	0
roflumilast	1	aromatic ether; benzamides; chloropyridine; cyclopropanes; organofluorine compound	anti-asthmatic drug; phosphodiesterase IV inhibitor	2023	2023	1.0	low	0	0	1
L-cycloserine	1	4-amino-1,2-oxazolidin-3-one	anti-HIV agent; anticonvulsant; EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor	2023	2023	1.0	low	0	0	1
h 89	1	N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide		2023	2023	1.0	low	0	0	1
bevirimat	1	dicarboxylic acid monoester; monocarboxylic acid; pentacyclic triterpenoid	HIV-1 maturation inhibitor; metabolite	2023	2023	1.0	low	0	0	1
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	1	amino aldehyde; carbamate ester; tripeptide	proteasome inhibitor	2023	2023	1.0	low	0	0	1
tenofovir	1	nucleoside analogue; phosphonic acids	antiviral drug; drug metabolite; HIV-1 reverse transcriptase inhibitor	2023	2023	1.0	low	0	0	1
posaconazole	1	aromatic ether; conazole antifungal drug; N-arylpiperazine; organofluorine compound; oxolanes; triazole antifungal drug; triazoles	trypanocidal drug	2023	2023	1.0	low	0	0	1
gw 257406x	1			2023	2023	1.0	low	0	0	1
shikonin	1	hydroxy-1,4-naphthoquinone		2023	2023	1.0	low	0	0	1
4,4-difluoro-N-[(1S)-3-[3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]-1-cyclohexanecarboxamide	2	tropane alkaloid		2013	2023	6.0	high	0	1	1
cmx 001	1			2023	2023	1.0	low	0	0	1
amd 8664	1			2023	2023	1.0	medium	0	0	1
bay 41-4109	1			2023	2023	1.0	low	0	0	1
bay 57-1293	1			2023	2023	1.0	low	0	0	1
2'-c-methylcytidine	1			2023	2023	1.0	low	0	0	1
isoxanthohumol	1	flavanones		2023	2023	1.0	low	0	0	1
4-(4-chloro-2-methylphenoxy)-n-hydroxybutanamide	1	aromatic ether		2023	2023	1.0	low	0	0	1
mecarbinate	1			2023	2023	1.0	low	0	0	1
s 1033	1	(trifluoromethyl)benzenes; imidazoles; pyridines; pyrimidines; secondary amino compound; secondary carboxamide	anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor	2013	2013	11.0	low	0	1	0
acetyl-aspartyl-glutamyl-valyl-aspartal	1	tetrapeptide	protease inhibitor	2023	2023	1.0	low	0	0	1
octotropine methylbromide	1			2023	2023	1.0	low	0	0	1
mercaptopurine	2	aryl thiol; purines; thiocarbonyl compound	anticoronaviral agent; antimetabolite; antineoplastic agent	2013	2023	6.0	low	0	1	1
jrf 12	1			2023	2023	1.0	low	0	0	1
3,4'-dihydroxyflavone	1			2023	2023	1.0	medium	0	0	1
rg108	1	indolyl carboxylic acid		2013	2013	11.0	low	0	1	0
3-(3,4-dimethoxyphenyl)propenoic acid	1	methoxycinnamic acid		2023	2023	1.0	low	0	0	1
stf 083010	1			2013	2013	11.0	medium	0	1	0
isoferulic acid	1	ferulic acids	antioxidant; biomarker; metabolite	2023	2023	1.0	low	0	0	1
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-naphthalenecarboxamide	1	naphthalenecarboxamide		2013	2013	11.0	low	0	1	0
cyclouridine	1			2023	2023	1.0	medium	0	0	1
curcumin	1	aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger	2023	2023	1.0	low	0	0	1
cct018159	1	benzodioxine; pyrazoles; resorcinols	antineoplastic agent; apoptosis inducer; Hsp90 inhibitor	2013	2013	11.0	low	0	1	0
secinh3	1	triazoles		2013	2013	11.0	low	0	1	0
jk184	1			2013	2013	11.0	low	0	1	0
zucapsaicin	1	methoxybenzenes; phenols		2023	2023	1.0	low	0	0	1
nbd 556	1			2023	2023	1.0	low	0	0	1
thioguanine anhydrous	1	2-aminopurines	anticoronaviral agent; antimetabolite; antineoplastic agent	2023	2023	1.0	low	0	0	1
4,5,6,7-tetrachloroindan-1,3-dione	1			2023	2023	1.0	medium	0	0	1
tamoxifen citrate	1	citrate salt	angiogenesis inhibitor; anticoronaviral agent	2013	2013	11.0	low	0	1	0
hc-067047	1			2013	2013	11.0	low	0	1	0
bi-78d3	1	aryl sulfide		2013	2013	11.0	low	0	1	0
srpin340	1			2023	2023	1.0	low	0	0	1
gsk 3787	1			2013	2013	11.0	low	0	1	0
pr-619	1			2023	2023	1.0	medium	0	0	1
p5091	1			2023	2023	1.0	low	0	0	1
methyl-thiohydantoin-tryptophan	1	organonitrogen compound; organooxygen compound		2013	2013	11.0	low	0	1	0
2-[2-chloro-6-ethoxy-4-[(3-methyl-5-oxo-1-phenyl-4-pyrazolylidene)methyl]phenoxy]acetic acid methyl ester	1	monocarboxylic acid		2013	2013	11.0	medium	0	1	0
4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1h-pyrazol-1-yl)benzenesulfonamide	1	sulfonamide		2013	2013	11.0	low	0	1	0
trovirdine	1			2023	2023	1.0	low	0	0	1
LSM-1318	1	oxa-steroid		2013	2013	11.0	low	0	1	0
fti 277	1			2023	2023	1.0	medium	0	0	1
u 0126	1	aryl sulfide; dinitrile; enamine; substituted aniline	antineoplastic agent; antioxidant; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; osteogenesis regulator; vasoconstrictor agent	2023	2023	1.0	low	0	0	1
rwj 67657	1			2013	2013	11.0	low	0	1	0
vicriviroc	1	(trifluoromethyl)benzenes		2023	2023	1.0	low	0	0	1
telaprevir	1	cyclopentapyrrole; cyclopropanes; oligopeptide; pyrazines	antiviral drug; hepatitis C protease inhibitor; peptidomimetic	2023	2023	1.0	low	0	0	1
6-methyl-2-(phenylethynyl)pyridine	1	acetylenic compound; methylpyridines	anxiolytic drug; metabotropic glutamate receptor antagonist	2013	2013	11.0	low	0	1	0
bms 387032	1	1,3-oxazoles; 1,3-thiazoles; organic sulfide; piperidinecarboxamide; secondary carboxamide	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor	2013	2013	11.0	low	0	1	0
orlistat	1	beta-lactone; carboxylic ester; formamides; L-leucine derivative	anti-obesity agent; bacterial metabolite; EC 2.3.1.85 (fatty acid synthase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor	2023	2023	1.0	low	0	0	1
tandutinib	1	aromatic ether; N-arylpiperazine; N-carbamoylpiperazine; phenylureas; piperidines; quinazolines; tertiary amino compound	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	2013	2013	11.0	low	0	1	0
vx-745	1	aryl sulfide; dichlorobenzene; difluorobenzene; pyrimidopyridazine	anti-inflammatory drug; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	2013	2013	11.0	low	0	1	0
corlanor	1	hydrochloride	cardiotonic drug	2013	2013	11.0	medium	0	1	0
dasatinib	2	1,3-thiazoles; aminopyrimidine; monocarboxylic acid amide; N-(2-hydroxyethyl)piperazine; N-arylpiperazine; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor	2013	2023	6.0	low	0	1	1
zd 6474	1	aromatic ether; organobromine compound; organofluorine compound; piperidines; quinazolines; secondary amine	antineoplastic agent; tyrosine kinase inhibitor	2013	2013	11.0	low	0	1	0
compound 968	1	benzophenanthridine	EC 3.5.1.2 (glutaminase) inhibitor	2013	2013	11.0	low	0	1	0
yya-021	1			2023	2023	1.0	medium	0	0	1
sb-224289	1	1,2,4-oxadiazole; azaspiro compound; benzamides; organic heterotetracyclic compound	serotonergic antagonist	2013	2013	11.0	low	0	1	0
gw 7647	1	aryl sulfide; monocarboxylic acid; ureas	PPARalpha agonist	2013	2013	11.0	low	0	1	0
l 663536	1	aryl sulfide; indoles; monocarboxylic acid; monochlorobenzenes	antineoplastic agent; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; leukotriene antagonist	2013	2013	11.0	low	0	1	0
1-[6-(4-chlorophenyl)-5-imidazo[2,1-b]thiazolyl]-N-[(3,4-dichlorophenyl)methoxy]methanimine	1	imidazoles		2013	2013	11.0	medium	0	1	0
N4-ethyl-N6,1,2-trimethyl-N4-phenylpyrimidin-1-ium-4,6-diamine	1	aromatic amine; tertiary amino compound		2013	2013	11.0	medium	0	1	0
2-[[2-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]propanoic acid ethyl ester	1	isoquinolines		2013	2013	11.0	low	0	1	0
sb 415286	1	C-nitro compound; maleimides; monochlorobenzenes; phenols; secondary amino compound; substituted aniline	antioxidant; apoptosis inducer; EC 2.7.11.26 (tau-protein kinase) inhibitor; neuroprotective agent	2023	2023	1.0	low	0	0	1
sch 79797	1	quinazolines		2013	2013	11.0	low	0	1	0
sitagliptin	1	triazolopyrazine; trifluorobenzene	EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor; environmental contaminant; hypoglycemic agent; serine proteinase inhibitor; xenobiotic	2023	2023	1.0	low	0	0	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide	1	benzamides; benzodioxoles; imidazoles; pyridines	EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	2013	2013	11.0	low	0	1	0
1-(4-Fluorophenyl)-3-(3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one	1	monobactam		2013	2013	11.0	medium	0	1	0
imd 0354	1	benzamides		2013	2013	11.0	low	0	1	0
ex 527	1	carbazoles; monocarboxylic acid amide; organochlorine compound		2013	2013	11.0	low	0	1	0
tak-220	1			2023	2023	1.0	medium	0	0	1
jtk-303	1	aromatic ether; monochlorobenzenes; organofluorine compound; quinolinemonocarboxylic acid; quinolone	HIV-1 integrase inhibitor	2023	2023	1.0	low	0	0	1
nbd 557	1			2023	2023	1.0	medium	0	0	1
quercetin	1	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger	2013	2013	11.0	low	0	1	0
5'-o-caffeoylquinic acid	1	cinnamate ester; cyclitol carboxylic acid	plant metabolite	2023	2023	1.0	medium	0	0	1
luteolin-7-glucoside	1	beta-D-glucoside; glycosyloxyflavone; monosaccharide derivative; trihydroxyflavone	antioxidant; plant metabolite	2023	2023	1.0	low	0	0	1
cyclosporine	1			2023	2023	1.0	low	0	0	1
harmine	1	harmala alkaloid	anti-HIV agent; EC 1.4.3.4 (monoamine oxidase) inhibitor; metabolite	2023	2023	1.0	low	0	0	1
genistein	1	7-hydroxyisoflavones	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; human urinary metabolite; phytoestrogen; plant metabolite; tyrosine kinase inhibitor	2013	2013	11.0	low	0	1	0
eprosartan	1	dicarboxylic acid; imidazoles; thiophenes	angiotensin receptor antagonist; antihypertensive agent; environmental contaminant; xenobiotic	2023	2023	1.0	low	0	0	1
mycophenolate mofetil	1	carboxylic ester; ether; gamma-lactone; phenols; tertiary amino compound	anticoronaviral agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; immunosuppressive agent; prodrug	2023	2023	1.0	low	0	0	1
entacapone	1	2-nitrophenols; catechols; monocarboxylic acid amide; nitrile	antidyskinesia agent; antiparkinson drug; central nervous system drug; EC 2.1.1.6 (catechol O-methyltransferase) inhibitor	2023	2023	1.0	low	0	0	1
amentoflavone	1	biflavonoid; hydroxyflavone; ring assembly	angiogenesis inhibitor; antiviral agent; cathepsin B inhibitor; P450 inhibitor; plant metabolite	2023	2023	1.0	low	0	0	1
baicalein	1	trihydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antibacterial agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antioxidant; apoptosis inducer; EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; EC 4.1.1.17 (ornithine decarboxylase) inhibitor; ferroptosis inhibitor; geroprotector; hormone antagonist; plant metabolite; prostaglandin antagonist; radical scavenger	2023	2023	1.0	low	0	0	1
genkwanin	1	dihydroxyflavone; monomethoxyflavone	metabolite	2023	2023	1.0	low	0	0	1
hyperoside	1	beta-D-galactoside; monosaccharide derivative; quercetin O-glycoside; tetrahydroxyflavone	hepatoprotective agent; plant metabolite	2023	2023	1.0	low	0	0	1
mangostin	1	aromatic ether; phenols; xanthones	antimicrobial agent; antineoplastic agent; antioxidant; plant metabolite	2023	2023	1.0	low	0	0	1
3-methylquercetin	1	7-hydroxyflavonol; monomethoxyflavone; tetrahydroxyflavone	anticoagulant; EC 1.14.18.1 (tyrosinase) inhibitor; metabolite	2023	2023	1.0	low	0	0	1
kaempferide	1	7-hydroxyflavonol; monomethoxyflavone; trihydroxyflavone	antihypertensive agent; metabolite	2023	2023	1.0	low	0	0	1
orientin	1	3'-hydroxyflavonoid; C-glycosyl compound; tetrahydroxyflavone	antioxidant; metabolite	2023	2023	1.0	low	0	0	1
scutellarein	1	tetrahydroxyflavone	metabolite	2023	2023	1.0	low	0	0	1
trans-2,3',4,5'-tetrahydroxystilbene	1	stilbenoid		2023	2023	1.0	low	0	0	1
polydatin	1	beta-D-glucoside; monosaccharide derivative; polyphenol; stilbenoid	anti-arrhythmia drug; antioxidant; geroprotector; hepatoprotective agent; metabolite; nephroprotective agent; potassium channel modulator	2023	2023	1.0	low	0	0	1
chicoric acid	1	organooxygen compound	geroprotector; HIV-1 integrase inhibitor	2023	2023	1.0	low	0	0	1
acteoside	1	catechols; cinnamate ester; disaccharide derivative; glycoside; polyphenol	anti-inflammatory agent; antibacterial agent; antileishmanial agent; neuroprotective agent; plant metabolite	2023	2023	1.0	low	0	0	1
dorzolamide	1	sulfonamide; thiophenes	antiglaucoma drug; antihypertensive agent; EC 4.2.1.1 (carbonic anhydrase) inhibitor	2023	2023	1.0	low	0	0	1
topiramate	1	cyclic ketal; ketohexose derivative; sulfamate ester	anticonvulsant; sodium channel blocker	2023	2023	1.0	low	0	0	1
fenretinide	1	monocarboxylic acid amide; retinoid	antineoplastic agent; antioxidant	2013	2013	11.0	low	0	1	0
ter 199	1			2013	2013	11.0	low	0	1	0
arachidonylcyclopropylamide	1			2013	2013	11.0	low	0	1	0
benzyloxycarbonyl-phe-ala-fluormethylketone	1			2023	2023	1.0	medium	0	0	1
ly 320135	1	benzofurans		2013	2013	11.0	low	0	1	0
n-(n-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	1	carboxylic ester; difluorobenzene; dipeptide; tert-butyl ester	EC 3.4.23.46 (memapsin 2) inhibitor	2023	2023	1.0	low	0	0	1
pd 166285	1			2013	2013	11.0	low	0	1	0
kn 62	1	piperazines		2013	2013	11.0	low	0	1	0
su 6656	1			2013	2013	11.0	low	0	1	0
casticin	1	dihydroxyflavone; tetramethoxyflavone	apoptosis inducer; plant metabolite	2023	2023	1.0	low	0	0	1
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	1	dihydroxyflavone; monomethoxyflavone	antineoplastic agent; EC 1.14.13.39 (nitric oxide synthase) inhibitor	2023	2023	1.0	low	0	0	1
(E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside	1	beta-D-glucoside; resorcinols; stilbenoid	anti-inflammatory agent; antioxidant; apoptosis inhibitor; cardioprotective agent; cyclooxygenase 2 inhibitor; platelet aggregation inhibitor	2023	2023	1.0	low	0	0	1
tyrphostin ag 555	1			2023	2023	1.0	low	0	0	1
semaxinib	1	olefinic compound; oxindoles; pyrroles	angiogenesis modulating agent; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; vascular endothelial growth factor receptor antagonist	2013	2013	11.0	low	0	1	0
su 11248	1	monocarboxylic acid amide; pyrroles	angiogenesis inhibitor; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; immunomodulator; neuroprotective agent; vascular endothelial growth factor receptor antagonist	2013	2013	11.0	low	0	1	0
palbociclib	1	aminopyridine; aromatic ketone; cyclopentanes; piperidines; pyridopyrimidine; secondary amino compound; tertiary amino compound	antineoplastic agent; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor	2013	2013	11.0	low	0	1	0
jnj-7706621	1	sulfonamide		2013	2013	11.0	low	0	1	0
romidepsin	1	cyclodepsipeptide; heterocyclic antibiotic; organic disulfide	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor	2010	2010	14.0	low	1	0	0
pd 151746	1			2023	2023	1.0	medium	0	0	1
lisinopril	1	dipeptide	EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor	2023	2023	1.0	low	0	0	1
verteporfin	1			2023	2023	1.0	low	0	0	1
batimastat	1	hydroxamic acid; L-phenylalanine derivative; organic sulfide; secondary carboxamide; thiophenes; triamide	angiogenesis inhibitor; antineoplastic agent; matrix metalloproteinase inhibitor	2023	2023	1.0	low	0	0	1
indinavir sulfate	1	dicarboxylic acid diamide; N-(2-hydroxyethyl)piperazine; piperazinecarboxamide	HIV protease inhibitor	2023	2023	1.0	low	0	0	1
cisplatin	1	diamminedichloroplatinum	antineoplastic agent; apoptosis inducer; cross-linking reagent; ferroptosis inducer; genotoxin; mutagen; nephrotoxin; photosensitizing agent	2013	2013	11.0	low	0	1	0
solanesol	1	nonaprenol; primary alcohol	plant metabolite	2023	2023	1.0	low	0	0	1
pepstatin	1	pentapeptide; secondary carboxamide	bacterial metabolite; EC 3.4.23.* (aspartic endopeptidase) inhibitor	2023	2023	1.0	low	0	0	1
l 685458	1	carbamate ester; monocarboxylic acid amide; peptide; secondary alcohol	EC 3.4.23.46 (memapsin 2) inhibitor; peptidomimetic	2023	2023	1.0	low	0	0	1
vx680	1	N-arylpiperazine		2013	2013	11.0	low	0	1	0
bms 806	1			2023	2023	1.0	low	0	0	1
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	1			2023	2023	1.0	medium	0	0	1
tulobuterol hydrochloride	1	organic molecular entity		2023	2023	1.0	low	0	0	1
salubrinal	1	aminal; organochlorine compound; quinolines; secondary carboxamide; thioureas		2023	2023	1.0	low	0	0	1
d 4476	1	imidazoles		2013	2013	11.0	low	0	1	0
cyc 116	1			2013	2013	11.0	low	0	1	0
bay 19-8004	1			2013	2013	11.0	low	0	1	0
germacrone	1	germacrane sesquiterpenoid; olefinic compound	androgen antagonist; anti-inflammatory agent; antifeedant; antifungal agent; antimicrobial agent; antineoplastic agent; antioxidant; antitussive; antiviral agent; apoptosis inducer; autophagy inducer; hepatoprotective agent; insecticide; neuroprotective agent; plant metabolite; volatile oil component	2023	2023	1.0	low	0	0	1
(2e,4e,6e,10e)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid	1			2023	2023	1.0	low	0	0	1
lithospermic acid	1			2023	2023	1.0	medium	0	0	1
laq824	6			2008	2023	12.0	low	3	2	1
ekb 569	1	aminoquinoline; monocarboxylic acid amide; monochlorobenzenes; nitrile	protein kinase inhibitor	2023	2023	1.0	low	0	0	1
axitinib	1	aryl sulfide; benzamides; indazoles; pyridines	antineoplastic agent; tyrosine kinase inhibitor; vascular endothelial growth factor receptor antagonist	2013	2013	11.0	low	0	1	0

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Chemical phylogenetics of histone deacetylases.
Nature chemical biology, , Volume: 6, Issue:3, 2010

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Chemical phylogenetics of histone deacetylases.
Nature chemical biology, , Volume: 6, Issue:3, 2010

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Chemical phylogenetics of histone deacetylases.
Nature chemical biology, , Volume: 6, Issue:3, 2010

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

Chemical phylogenetics of histone deacetylases.
Nature chemical biology, , Volume: 6, Issue:3, 2010

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020

Stabilizing HDAC11 with SAHA to assay slow-binding benzamide inhibitors.
Bioorganic & medicinal chemistry letters, , 07-01, Volume: 27, Issue:13, 2017

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

The discovery and optimization of novel dual inhibitors of topoisomerase II and histone deacetylase.
Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013

Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
Journal of medicinal chemistry, , Aug-08, Volume: 56, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 21, Issue:16, 2011

Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
Journal of medicinal chemistry, , Jul-14, Volume: 54, Issue:13, 2011

Chemical phylogenetics of histone deacetylases.
Nature chemical biology, , Volume: 6, Issue:3, 2010

Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 19, Issue:19, 2009

Sulfamides as novel histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 19, Issue:2, 2009

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 18, Issue:6, 2008

Histone deacetylase inhibitors: from bench to clinic.
Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

The discovery and optimization of novel dual inhibitors of topoisomerase II and histone deacetylase.
Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 19, Issue:19, 2009

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.
Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012

Chemical phylogenetics of histone deacetylases.
Nature chemical biology, , Volume: 6, Issue:3, 2010

Histone deacetylase inhibitors: from bench to clinic.
Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Chemical phylogenetics of histone deacetylases.
Nature chemical biology, , Volume: 6, Issue:3, 2010

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 21, Issue:16, 2011

Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
Journal of medicinal chemistry, , Jul-14, Volume: 54, Issue:13, 2011

Chemical phylogenetics of histone deacetylases.
Nature chemical biology, , Volume: 6, Issue:3, 2010

Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 19, Issue:19, 2009

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 18, Issue:6, 2008

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

Chemical phylogenetics of histone deacetylases.
Nature chemical biology, , Volume: 6, Issue:3, 2010

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Chemical phylogenetics of histone deacetylases.
Nature chemical biology, , Volume: 6, Issue:3, 2010

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 18, Issue:6, 2008

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 21, Issue:16, 2011

Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
Journal of medicinal chemistry, , Jul-14, Volume: 54, Issue:13, 2011

Chemical phylogenetics of histone deacetylases.
Nature chemical biology, , Volume: 6, Issue:3, 2010

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 18, Issue:6, 2008

Histone deacetylase inhibitors: from bench to clinic.
Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008

Histone deacetylase inhibitors: from bench to clinic.
Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.
Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012

Chemical phylogenetics of histone deacetylases.
Nature chemical biology, , Volume: 6, Issue:3, 2010

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Histone deacetylase inhibitors: from bench to clinic.
Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

Chemical phylogenetics of histone deacetylases.
Nature chemical biology, , Volume: 6, Issue:3, 2010

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Chemical phylogenetics of histone deacetylases.
Nature chemical biology, , Volume: 6, Issue:3, 2010

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Histone deacetylase inhibitors: from bench to clinic.
Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020

Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.
Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.
Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Disease models & mechanisms, , 03-01, Volume: 16, Issue:3, 2023

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
acetylcarnitine	2	O-acylcarnitine	human metabolite	2009	2021	9.0	low	0	0	0	1	0	1
dinitrochlorobenzene	8	C-nitro compound; monochlorobenzenes	allergen; epitope; sensitiser	2006	2019	10.5	low	0	0	0	2	6	0
1,2,4-trichlorobenzene	1	trichlorobenzene		2012	2012	12.0	low	0	0	0	0	1	0
2,3-dihydroxybenzoic acid	2	dihydroxybenzoic acid	human xenobiotic metabolite; plant metabolite	1989	1998	30.5	low	0	1	1	0	0	0
ethylene chlorohydrin	1	chloroethanol	xenobiotic metabolite	2018	2018	6.0	low	0	0	0	0	1	0
2,3-diphosphoglycerate	2	bisphosphoglyceric acid; tetronic acid derivative	human metabolite	1999	2006	21.5	low	0	0	1	1	0	0
protocatechuic acid	6	catechols; dihydroxybenzoic acid	antineoplastic agent; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor; human xenobiotic metabolite; plant metabolite	1998	2023	11.0	low	1	0	1	0	4	1
3-chloroalanine	1	chloroalanine; non-proteinogenic alpha-amino acid; organochlorine compound		1997	1997	27.0	low	0	0	1	0	0	0
3-hydroxyanthranilic acid	1	aminobenzoic acid; monohydroxybenzoic acid	human metabolite; mouse metabolite	1992	1992	32.0	low	0	0	1	0	0	0
acetoacetic acid	3	3-oxo fatty acid; ketone body	metabolite	1981	2000	33.0	low	0	1	2	0	0	0
phosphoserine	1	non-proteinogenic alpha-amino acid; O-phosphoamino acid; serine derivative	human metabolite	2015	2015	9.0	low	0	0	0	0	1	0
cysteine sulfinic acid	1			2015	2015	9.0	low	0	0	0	0	1	0
gamma-aminobutyric acid	10	amino acid zwitterion; gamma-amino acid; monocarboxylic acid	human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule	2002	2021	11.3	low	0	0	0	3	5	2
4-hydroxyphenylacetic acid	9	monocarboxylic acid; phenols	fungal metabolite; human metabolite; mouse metabolite; plant metabolite	1990	2005	27.4	low	0	0	6	3	0	0
4-hydroxybenzoic acid	2	monohydroxybenzoic acid	algal metabolite; plant metabolite	1995	2006	23.5	low	0	0	1	1	0	0
aminolevulinic acid	8	4-oxo monocarboxylic acid; amino acid zwitterion; delta-amino acid	antineoplastic agent; dermatologic drug; Escherichia coli metabolite; human metabolite; mouse metabolite; photosensitizing agent; plant metabolite; prodrug; Saccharomyces cerevisiae metabolite	1987	2022	16.1	low	0	1	1	2	3	1
5-hydroxytryptophan	2	hydroxytryptophan	human metabolite; neurotransmitter	2001	2003	22.0	low	0	0	0	2	0	0
ethylene glycol	2	ethanediol; glycol	metabolite; mouse metabolite; solvent; toxin	2009	2023	8.0	low	1	0	0	1	0	1
acetic acid	147	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent	1984	2023	16.6	low	0	3	33	50	52	9
acetaldehyde	17	aldehyde	carcinogenic agent; EC 3.5.1.4 (amidase) inhibitor; electron acceptor; Escherichia coli metabolite; human metabolite; mouse metabolite; mutagen; oxidising agent; Saccharomyces cerevisiae metabolite; teratogenic agent	1979	2013	29.7	low	0	6	8	2	1	0
acetone	11	ketone body; methyl ketone; propanones; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; human metabolite; polar aprotic solvent	1986	2022	20.6	low	0	1	3	6	0	1
adenine	21	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1946	2023	21.6	low	1	4	3	6	6	2
agmatine	5	guanidines; primary amino compound	Escherichia coli metabolite; mouse metabolite	2007	2017	11.6	low	0	0	0	2	3	0
allantoin	6	imidazolidine-2,4-dione; ureas	Escherichia coli metabolite; human metabolite; Saccharomyces cerevisiae metabolite; vulnerary	2011	2019	7.8	low	0	0	0	0	6	0
ammonium hydroxide	15	azane; gas molecular entity; mononuclear parent hydride	EC 3.5.1.4 (amidase) inhibitor; metabolite; mouse metabolite; neurotoxin; NMR chemical shift reference compound; nucleophilic reagent; refrigerant	1964	2022	21.7	low	0	3	3	3	4	2
anthranilic acid	2	aminobenzoic acid	human metabolite; mouse metabolite	2012	2013	11.5	low	0	0	0	0	2	0
arsenic acid	7	arsenic oxoacid	Escherichia coli metabolite	1949	2019	20.6	low	0	1	0	2	4	0
quinacrine	9	acridines; aromatic ether; organochlorine compound; tertiary amino compound	antimalarial; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor	1946	2017	33.8	low	0	4	3	1	1	0
beta-alanine	6	amino acid zwitterion; beta-amino acid	agonist; fundamental metabolite; human metabolite; inhibitor; neurotransmitter	1997	2015	19.0	low	0	0	1	4	1	0
benzene	28	aromatic annulene; benzenes; volatile organic compound	carcinogenic agent; environmental contaminant; non-polar solvent	1953	2018	26.9	low	0	6	8	10	4	0
benzoic acid	5	benzoic acids	algal metabolite; antimicrobial food preservative; drug allergen; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor; human xenobiotic metabolite; plant metabolite	1985	2015	23.4	low	0	2	0	1	2	0
betaine	10	amino-acid betaine; glycine derivative	fundamental metabolite	2004	2021	7.7	low	0	0	0	2	6	2
bromide	42	halide anion; monoatomic bromine		1979	2022	23.5	low	0	10	11	12	8	1
1-butanol	7	alkyl alcohol; primary alcohol; short-chain primary fatty alcohol	human metabolite; mouse metabolite; protic solvent	1992	2022	11.3	low	0	0	1	2	2	2
butyric acid	10	fatty acid 4:0; straight-chain saturated fatty acid	human urinary metabolite; Mycoplasma genitalium metabolite	1989	2018	19.3	low	0	1	2	2	5	0
cadaverine	4	alkane-alpha,omega-diamine	Daphnia magna metabolite; Escherichia coli metabolite; mouse metabolite; plant metabolite	1994	2021	18.0	low	0	0	2	1	0	1
carbamates	8	amino-acid anion		2007	2022	10.5	low	0	0	0	3	4	1
carbon monoxide	54	carbon oxide; gas molecular entity; one-carbon compound	biomarker; EC 1.9.3.1 (cytochrome c oxidase) inhibitor; human metabolite; ligand; metabolite; mitochondrial respiratory-chain inhibitor; mouse metabolite; neurotoxin; neurotransmitter; P450 inhibitor; probe; signalling molecule; vasodilator agent	1950	2021	19.5	low	1	8	1	26	18	1
formic acid	6	monocarboxylic acid	antibacterial agent; astringent; metabolite; protic solvent; solvent	1998	2023	15.7	low	0	0	3	0	2	1
aminooxyacetic acid	1	amino acid; hydroxylamines; monocarboxylic acid	anticonvulsant; EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor; EC 4.2.1.22 (cystathionine beta-synthase) inhibitor; nootropic agent	1981	1981	43.0	low	0	1	0	0	0	0
carnitine	8	amino-acid betaine	human metabolite; mouse metabolite	1998	2020	14.6	low	0	0	1	4	3	0
catechol	12	catechols	allelochemical; genotoxin; plant metabolite	1962	2017	22.5	low	0	2	3	2	5	0
methane	59	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas	1977	2023	9.9	low	1	1	1	4	50	3
choline	23	cholines	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; neurotransmitter; nutrient; plant metabolite; Saccharomyces cerevisiae metabolite	1949	2022	26.9	low	0	5	4	7	6	1
citric acid, anhydrous	21	tricarboxylic acid	antimicrobial agent; chelator; food acidity regulator; fundamental metabolite	1964	2020	17.1	low	1	3	3	2	13	0
chlorine	229	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite	1952	2022	30.0	low	1	95	68	44	18	4
hydrochloric acid	20	chlorine molecular entity; gas molecular entity; hydrogen halide; mononuclear parent hydride	mouse metabolite	1980	2018	18.2	low	0	1	5	6	8	0
coumarin	9	coumarins	fluorescent dye; human metabolite; plant metabolite	2004	2020	10.6	low	0	0	0	2	7	0
salicylic acid	68	monohydroxybenzoic acid	algal metabolite; antifungal agent; antiinfective agent; EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor; keratolytic drug; plant hormone; plant metabolite	1989	2021	13.3	low	0	1	4	31	28	4
phloroglucinol	7	benzenetriol; phenolic donor	algal metabolite	1989	2012	18.3	low	0	1	0	3	3	0
2,3-diaminopropionic acid	1	alanine derivative; amino acid zwitterion; beta-amino acid; diamino acid; non-proteinogenic alpha-amino acid	Escherichia coli metabolite	2001	2001	23.0	low	0	0	0	1	0	0
gallic acid	23	trihydroxybenzoic acid	antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite	1981	2023	15.3	low	0	2	2	6	9	4
4-nitrophenylphosphate	1	aryl phosphate	mouse metabolite	1990	1990	34.0	low	0	0	1	0	0	0
hydrogen sulfide	49	gas molecular entity; hydracid; mononuclear parent hydride; sulfur hydride	Escherichia coli metabolite; genotoxin; metabolite; signalling molecule; toxin; vasodilator agent	1989	2023	11.5	low	1	1	1	14	29	4
4-aminophenol	2	aminophenol	allergen; metabolite	2007	2014	13.5	low	0	0	0	1	1	0
dihydrolipoic acid	4	thio-fatty acid	antioxidant; human metabolite; neuroprotective agent	1995	2003	24.0	low	0	0	2	2	0	0
3-hydroxybutyric acid	3	(omega-1)-hydroxy fatty acid; 3-hydroxy monocarboxylic acid; hydroxybutyric acid	human metabolite	1992	2014	20.0	low	0	0	1	1	1	0
3-chlorobenzoic acid	1	monochlorobenzoic acid	drug metabolite	1993	1993	31.0	low	0	0	1	0	0	0
caprylic aldehyde	1	medium-chain fatty aldehyde; n-alkanal; saturated fatty aldehyde	plant metabolite	2017	2017	7.0	low	0	0	0	0	1	0
guaiacol	53	guaiacols	disinfectant; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; expectorant; plant metabolite	1975	2023	23.5	low	0	15	5	14	18	1
2-keto-4-methylthiobutyric acid	3	omega-(methylthio)-2-oxocarboxylic acid		1985	2006	28.7	low	0	1	1	1	0	0
methylmalonic acid	1	C4-dicarboxylic acid	human metabolite	2011	2011	13.0	low	0	0	0	0	1	0
n(g),n(g')-dimethyl-l-arginine	17	alpha-amino acid		2005	2018	11.6	low	1	0	0	6	11	0
malic acid	5	2-hydroxydicarboxylic acid; C4-dicarboxylic acid	food acidity regulator; fundamental metabolite	2003	2019	10.4	low	0	0	0	1	4	0
propionaldehyde	1	alpha-CH2-containing aldehyde; propanals	Escherichia coli metabolite	1997	1997	27.0	low	0	0	1	0	0	0
1-aminocyclopropane-1-carboxylic acid	5	amino acid zwitterion; monocarboxylic acid; non-proteinogenic alpha-amino acid	ethylene releasers; plant metabolite	1995	2011	23.6	low	0	0	3	1	1	0
3,4-dihydroxyphenylacetic acid	1	catechols; dihydroxyphenylacetic acid	human metabolite	2011	2011	13.0	low	0	0	0	0	1	0
aminocaproic acid	2	amino acid zwitterion; epsilon-amino acid; omega-amino fatty acid	antifibrinolytic drug; hematologic agent; metabolite	1964	2010	37.0	low	0	1	0	1	0	0
creatine	8	glycine derivative; guanidines; zwitterion	geroprotector; human metabolite; mouse metabolite; neuroprotective agent; nutraceutical	1993	2015	18.6	low	1	0	2	4	2	0
cytosine	6	aminopyrimidine; pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1997	2021	14.2	low	0	0	2	1	1	2
lactic acid	60	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite	1951	2022	14.8	low	5	2	6	20	30	2
diacetyl	1	alpha-diketone	Escherichia coli metabolite; Saccharomyces cerevisiae metabolite	1989	1989	35.0	low	0	1	0	0	0	0
dimethyl sulfoxide	39	sulfoxide; volatile organic compound	alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger	1979	2023	30.3	low	2	19	9	6	4	1
formaldehyde	29	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1951	2021	17.1	low	0	2	5	6	15	1
glutaric acid	1	alpha,omega-dicarboxylic acid; dicarboxylic fatty acid	Daphnia magna metabolite; human metabolite	1950	1950	74.0	low	0	1	0	0	0	0
glycine	70	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical	1964	2023	17.4	low	0	4	14	24	21	7
glycerol	10	alditol; triol	algal metabolite; detergent; Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; solvent	1987	2023	16.6	low	1	1	2	1	4	2
glycerol	11	alditol; triol	algal metabolite; detergent; Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; solvent	1987	2023	15.6	low	1	1	2	1	5	2
glycolaldehyde	2	glycolaldehydes	fundamental metabolite; human metabolite	1997	2005	23.0	low	0	0	1	1	0	0
glycocyamine	1	guanidinoacetic acids; zwitterion	bacterial metabolite; human metabolite; mouse metabolite; nutraceutical; rat metabolite	1983	1983	41.0	low	0	1	0	0	0	0
carbonic acid	1	carbon oxoacid; chalcocarbonic acid	mouse metabolite	2001	2001	23.0	low	0	0	0	1	0	0
hydrogen cyanide	9	hydracid; one-carbon compound	Escherichia coli metabolite; human metabolite; poison	1950	2023	17.1	low	0	2	0	1	3	3
hydrogen cyanide	3	hydracid; one-carbon compound	Escherichia coli metabolite; human metabolite; poison	1950	2003	44.7	low	0	2	0	1	0	0
hydrogen carbonate	15	carbon oxoanion	cofactor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1950	2020	22.8	low	0	1	3	10	1	0
dalteparin	9			2001	2016	13.7	low	1	0	0	4	5	0
histamine	96	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter	1951	2023	22.3	low	10	9	30	42	12	3
histamine	93	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter	1951	2023	22.6	low	10	9	30	39	12	3
homogentisic acid	1	dihydroxyphenylacetic acid; hydroquinones	human metabolite; plant metabolite	1999	1999	25.0	low	0	0	1	0	0	0
hydrogen	38	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite	1946	2023	24.7	low	1	8	2	7	19	2
hydroquinone	28	benzenediol; hydroquinones	antioxidant; carcinogenic agent; cofactor; Escherichia coli metabolite; human xenobiotic metabolite; mouse metabolite; skin lightening agent	1989	2023	23.2	low	0	2	13	7	5	1
hydroxylamine	5	hydroxylamines	algal metabolite; bacterial xenobiotic metabolite; EC 1.1.3.13 (alcohol oxidase) inhibitor; EC 4.2.1.22 (cystathionine beta-synthase) inhibitor; EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor; nitric oxide donor; nucleophilic reagent	2002	2014	16.4	low	0	0	0	3	2	0
imidazole	10	imidazole		1988	2022	17.2	low	0	1	2	3	2	2
indole	4	indole; polycyclic heteroarene	Escherichia coli metabolite	1955	2006	41.5	low	0	2	0	2	0	0
indoleacetic acid	43	indole-3-acetic acids; monocarboxylic acid	auxin; human metabolite; mouse metabolite; plant hormone; plant metabolite	1955	2023	25.0	low	0	11	4	9	17	2
iodine	41	diatomic iodine	nutrient	1952	2020	36.4	low	0	26	8	5	2	0
iodine	43	diatomic iodine	nutrient	1952	2020	34.9	low	0	26	8	5	4	0
dihydroxyphenylalanine	11	hydroxyphenylalanine; non-proteinogenic alpha-amino acid; tyrosine derivative	human metabolite	1953	2018	36.5	low	0	5	2	2	2	0
kynurenine	7	aromatic ketone; non-proteinogenic alpha-amino acid; substituted aniline	human metabolite	1950	2014	36.3	low	0	3	1	1	2	0
thioctic acid	30	dithiolanes; heterocyclic fatty acid; thia fatty acid	fundamental metabolite; geroprotector	1995	2020	13.7	low	0	0	3	13	14	0
thioctic acid	28	dithiolanes; heterocyclic fatty acid; thia fatty acid	fundamental metabolite; geroprotector	1995	2020	13.7	low	0	0	3	11	14	0
pyruvaldehyde	3	2-oxo aldehyde; propanals	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2012	2014	11.3	low	0	0	0	0	3	0
methanol	21	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite	1963	2020	15.6	low	0	1	0	9	11	0
methanol	37	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite	1963	2020	14.8	low	0	1	1	17	18	0
phytic acid	2	inositol phosphate		1994	2021	16.5	low	0	0	1	0	0	1
inositol	2	cyclitol; hexol		2007	2022	9.5	low	0	0	0	1	0	1
melatonin	109	acetamides; tryptamines	anticonvulsant; central nervous system depressant; geroprotector; hormone; human metabolite; immunological adjuvant; mouse metabolite; radical scavenger	1997	2023	15.3	low	1	0	10	63	30	6
croton oil	19	N-acyl-hexosamine		1995	2021	13.3	low	0	0	1	6	10	2
naphthalene	6	naphthalenes; ortho-fused bicyclic arene	apoptosis inhibitor; carcinogenic agent; environmental contaminant; mouse metabolite; plant metabolite; volatile oil component	2005	2020	11.3	low	0	0	0	2	4	0
nickel	48	metal allergen; nickel group element atom	epitope; micronutrient	1951	2023	12.0	low	1	2	2	9	29	6
niacinamide	8	pyridine alkaloid; pyridinecarboxamide; vitamin B3	anti-inflammatory agent; antioxidant; cofactor; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; Escherichia coli metabolite; geroprotector; human urinary metabolite; metabolite; mouse metabolite; neuroprotective agent; Saccharomyces cerevisiae metabolite; Sir2 inhibitor	1995	2021	18.9	low	0	0	4	1	2	1
niacin	8	pyridine alkaloid; pyridinemonocarboxylic acid; vitamin B3	antidote; antilipemic drug; EC 3.5.1.19 (nicotinamidase) inhibitor; Escherichia coli metabolite; human urinary metabolite; metabolite; mouse metabolite; plant metabolite; vasodilator agent	1959	2015	27.5	low	1	2	1	2	3	0
nitrates	200	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species		1992	2022	17.9	low	2	0	57	86	55	2
nitric acid	2	nitrogen oxoacid	protic solvent; reagent	2013	2018	8.5	low	0	0	0	0	2	0
nitroxyl	7	nitrogen oxoacid		2003	2013	15.4	low	0	0	0	4	3	0
nitrites	265	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species	human metabolite	1990	2023	17.4	low	5	0	57	127	77	4
nitrous oxide	1	gas molecular entity; nitrogen oxide	analgesic; bacterial metabolite; food packaging gas; food propellant; general anaesthetic; greenhouse gas; inhalation anaesthetic; NMDA receptor antagonist; raising agent; refrigerant; vasodilator agent	2006	2006	18.0	low	0	0	0	1	0	0
1-octanol	1	octanol; primary alcohol	antifungal agent; bacterial metabolite; fuel additive; kairomone; plant metabolite	1992	1992	32.0	low	0	0	1	0	0	0
hydroxide ion	2	oxygen hydride	mouse metabolite	1988	2008	26.0	low	0	1	0	1	0	0
oxaloacetic acid	1	C4-dicarboxylic acid; oxo dicarboxylic acid	geroprotector; metabolite	1950	1950	74.0	low	0	1	0	0	0	0
oxalic acid	6	alpha,omega-dicarboxylic acid	algal metabolite; human metabolite; plant metabolite	2017	2020	5.7	low	0	0	0	0	6	0
oxamic acid	3	dicarboxylic acid monoamide	Escherichia coli metabolite	1988	1997	32.3	low	0	1	2	0	0	0
4-aminobenzoic acid	8	aminobenzoic acid; aromatic amino-acid zwitterion	allergen; Escherichia coli metabolite; plant metabolite	2012	2020	9.2	low	0	0	0	0	8	0
4-nitrophenol	7	4-nitrophenols	human xenobiotic metabolite; mouse metabolite	2011	2021	8.7	low	0	0	0	0	6	1
palmitic acid	4	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor; plant metabolite	2011	2015	11.0	low	0	0	0	0	4	0
pentachlorophenol	3	aromatic fungicide; chlorophenol; organochlorine pesticide; pentachlorobenzenes	human xenobiotic metabolite	2005	2011	16.3	low	0	0	0	2	1	0
phenanthrene	6	ortho-fused polycyclic arene; ortho-fused tricyclic hydrocarbon; phenanthrenes	environmental contaminant; mouse metabolite	2008	2020	9.5	low	0	0	0	1	5	0
phenol	63	phenols	antiseptic drug; disinfectant; human xenobiotic metabolite; mouse metabolite	1946	2023	20.2	low	0	9	15	20	16	3
phenylacetaldehyde	2	alpha-CH2-containing aldehyde; phenylacetaldehydes	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1987	1989	36.0	low	0	2	0	0	0	0
phenylacetic acid	1	benzenes; monocarboxylic acid; phenylacetic acids	allergen; Aspergillus metabolite; auxin; EC 6.4.1.1 (pyruvate carboxylase) inhibitor; Escherichia coli metabolite; human metabolite; plant growth retardant; plant metabolite; Saccharomyces cerevisiae metabolite; toxin	2004	2004	20.0	low	0	0	0	1	0	0
phenethylamine	1	alkaloid; aralkylamine; phenylethylamine	Escherichia coli metabolite; human metabolite; mouse metabolite	1946	1946	78.0	low	0	1	0	0	0	0
phosphoenolpyruvate	1	carboxyalkyl phosphate; monocarboxylic acid	fundamental metabolite	2000	2000	24.0	low	0	0	1	0	0	0
phosphorylcholine	6	phosphocholines	allergen; epitope; hapten; human metabolite; mouse metabolite	1991	2010	19.5	low	1	0	1	5	0	0
phthalic acid	1	benzenedicarboxylic acid	human xenobiotic metabolite	2009	2009	15.0	low	0	0	0	1	0	0
diphosphoric acid	3	acyclic phosphorus acid anhydride; phosphorus oxoacid	Escherichia coli metabolite	2018	2019	5.3	low	0	0	0	0	3	0
pqq cofactor	1	orthoquinones; pyrroloquinoline cofactor; tricarboxylic acid	anti-inflammatory agent; antioxidant; cofactor; water-soluble vitamin (role)	2017	2017	7.0	low	0	0	0	0	1	0
propylene glycol	1	glycol; propane-1,2-diols	allergen; human xenobiotic metabolite; mouse metabolite; protic solvent	2015	2015	9.0	low	0	0	0	0	1	0
propionic acid	4	saturated fatty acid; short-chain fatty acid	antifungal drug	1955	2006	33.8	low	0	1	1	2	0	0
pteridines	2	azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; pteridines		2006	2007	17.5	low	0	0	0	2	0	0
purine	3	purine		1950	2008	37.7	low	0	1	0	2	0	0
putrescine	14	alkane-alpha,omega-diamine	antioxidant; fundamental metabolite	2000	2021	14.4	low	0	0	1	7	5	1
pyrazinamide	2	monocarboxylic acid amide; N-acylammonia; pyrazines	antitubercular agent; prodrug	1988	2021	19.5	low	0	1	0	0	0	1
pyrazole	2	pyrazole		2020	2021	3.5	low	0	0	0	0	1	1
pyridine	5	azaarene; mancude organic heteromonocyclic parent; monocyclic heteroarene; pyridines	environmental contaminant; NMR chemical shift reference compound	1950	2014	50.0	low	0	3	0	1	1	0
pyridoxal	2	hydroxymethylpyridine; methylpyridines; monohydroxypyridine; pyridinecarbaldehyde; vitamin B6	cofactor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1951	1991	53.0	low	0	1	1	0	0	0
pyridoxal phosphate	7	methylpyridines; monohydroxypyridine; pyridinecarbaldehyde; vitamin B6 phosphate	coenzyme; cofactor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1962	2011	38.3	low	0	3	2	1	1	0
pyridoxine	3	hydroxymethylpyridine; methylpyridines; monohydroxypyridine; vitamin B6	cofactor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1982	2020	19.3	low	0	1	0	0	2	0
pyrogallol	7	benzenetriol; phenolic donor	plant metabolite	1964	2017	26.0	low	0	2	0	1	4	0
pyruvic acid	13	2-oxo monocarboxylic acid	cofactor; fundamental metabolite	1986	2020	14.2	low	0	1	1	4	7	0
quinolinic acid	1	pyridinedicarboxylic acid	Escherichia coli metabolite; human metabolite; mouse metabolite; NMDA receptor agonist	2013	2013	11.0	low	0	0	0	0	1	0
dithionite	5	sulfur oxide; sulfur oxoanion		1980	2002	35.4	low	0	3	1	1	0	0
sarcosine	4	N-alkylglycine zwitterion; N-alkylglycine; N-methyl-amino acid; N-methylglycines	Escherichia coli metabolite; glycine receptor agonist; glycine transporter 1 inhibitor; human metabolite; mouse metabolite	1950	2022	21.8	low	0	1	0	0	2	1
selenic acid	3	selenium oxoacid		2010	2017	11.0	low	0	0	0	1	2	0
selenious acid	2	selenium oxoacid		2015	2016	8.5	low	0	0	0	0	2	0
sulfites	9	divalent inorganic anion; sulfur oxide; sulfur oxoanion		1961	2023	29.3	low	1	3	1	1	3	1
spermidine	15	polyazaalkane; triamine	autophagy inducer; fundamental metabolite; geroprotector	1995	2021	14.9	low	0	0	1	8	5	1
spermine	12	polyazaalkane; tetramine	antioxidant; fundamental metabolite; immunosuppressive agent	1997	2021	14.8	low	0	0	1	6	3	2
succinic acid	4	alpha,omega-dicarboxylic acid; C4-dicarboxylic acid	anti-ulcer drug; fundamental metabolite; micronutrient; nutraceutical; radiation protective agent	1994	2018	16.2	low	0	0	1	1	2	0
sulfur dioxide	5	sulfur oxide	Escherichia coli metabolite; food bleaching agent; refrigerant	2005	2017	14.0	low	0	0	0	3	2	0
taurine	101	amino sulfonic acid; zwitterion	antioxidant; Escherichia coli metabolite; glycine receptor agonist; human metabolite; mouse metabolite; nutrient; radical scavenger; Saccharomyces cerevisiae metabolite	1975	2022	22.0	low	1	13	29	39	18	2
thiamine	10	primary alcohol; vitamin B1	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1963	2023	17.4	low	0	2	1	1	3	3
thymine	4	pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite	1985	2022	22.0	low	0	1	1	1	0	1
toluene	4	methylbenzene; toluenes; volatile organic compound	cholinergic antagonist; fuel additive; neurotoxin; non-polar solvent	1984	2010	23.5	low	0	1	0	3	0	0
trimethyloxamine	3	tertiary amine oxide	Escherichia coli metabolite; metabolite; osmolyte	2014	2017	8.3	low	0	0	0	0	3	0
trimethylamine	1	methylamines; tertiary amine	Escherichia coli metabolite; human xenobiotic metabolite	2001	2001	23.0	low	0	0	0	1	0	0
tryptamine	1	aminoalkylindole; aralkylamino compound; indole alkaloid; tryptamines	human metabolite; mouse metabolite; plant metabolite	2015	2015	9.0	low	0	0	0	0	1	0
uracil	5	pyrimidine nucleobase; pyrimidone	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; prodrug; Saccharomyces cerevisiae metabolite	2001	2023	15.4	low	1	0	0	4	0	1
uric acid	105	uric acid	Escherichia coli metabolite; human metabolite; mouse metabolite	1964	2023	15.2	low	4	7	12	37	35	14
urea	41	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1948	2020	18.7	low	0	3	6	14	18	0
vanillin	4	benzaldehydes; monomethoxybenzene; phenols	anti-inflammatory agent; anticonvulsant; antioxidant; flavouring agent; plant metabolite	2017	2021	5.0	low	0	0	0	0	3	1
xanthine	15	xanthine	Saccharomyces cerevisiae metabolite	1949	2019	26.2	low	0	3	6	3	3	0
4-iodo-2,5-dimethoxyphenylisopropylamine	1	amphetamines; dimethoxybenzene; organoiodine compound		2007	2007	17.0	low	0	0	0	1	0	0
gallopamil	1	benzenes; organic amino compound		2016	2016	8.0	low	0	0	0	0	1	0
huperzine a	1	quinolone		2013	2013	11.0	low	0	0	0	0	1	0
menthol	3	p-menthane monoterpenoid; secondary alcohol	volatile oil component	2014	2019	7.3	low	0	0	0	0	3	0
1,10-phenanthroline	2	phenanthroline	EC 2.7.1.1 (hexokinase) inhibitor; EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor	2002	2013	16.5	low	0	0	0	1	1	0
1,2-dimethylhydrazine	2	hydrazines	alkylating agent; carcinogenic agent	1993	2018	18.5	low	0	0	1	0	1	0
1,3-dipropyl-8-cyclopentylxanthine	3	oxopurine	adenosine A1 receptor antagonist; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor	1997	2008	20.0	low	0	0	1	2	0	0
s,s'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea	2			2006	2007	17.5	low	0	0	0	2	0	0
1,5-dihydroxyisoquinoline	1	isoquinolinol	EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor	2007	2007	17.0	low	0	0	0	1	0	0
1-(1-naphthyl)piperazine	1	N-arylpiperazine		2016	2016	8.0	low	0	0	0	0	1	0
pk 11195	1	aromatic amide; isoquinolines; monocarboxylic acid amide; monochlorobenzenes	antineoplastic agent	2005	2005	19.0	low	0	0	0	1	0	0
1-(3-chlorophenyl)biguanide	2	biguanides; monochlorobenzenes		2010	2011	13.5	low	0	0	0	1	1	0
1-anilino-8-naphthalenesulfonate	90	aminonaphthalene; naphthalenesulfonic acid	fluorescent probe	1993	2021	14.3	low	2	0	8	38	41	3
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	3	methylpyridines; phenylpyridine; tetrahydropyridine	neurotoxin	2005	2017	13.3	low	0	0	0	2	1	0
1-methylimidazole	2	imidazoles		1989	2011	24.0	low	0	1	0	0	1	0
n-(3-(aminomethyl)benzyl)acetamidine	11	aralkylamine; carboxamidine; primary amino compound	angiogenesis inhibitor; EC 1.14.13.39 (nitric oxide synthase) inhibitor; geroprotector	2001	2019	16.5	low	0	0	0	7	4	0
1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	1	oxadiazoloquinoxaline	EC 4.6.1.2 (guanylate cyclase) inhibitor	2003	2003	21.0	low	0	0	0	1	0	0
2,2'-dipyridyl	2	bipyridine	chelator; ferroptosis inhibitor	2013	2015	10.0	low	0	0	0	0	2	0
2,4-dichlorophenoxyacetic acid	7	chlorophenoxyacetic acid; dichlorobenzene	agrochemical; defoliant; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; environmental contaminant; phenoxy herbicide; synthetic auxin	1994	2020	19.7	low	0	0	4	1	2	0
2,4-dinitrophenol	4	dinitrophenol	allergen; antiseptic drug; bacterial xenobiotic metabolite; geroprotector; oxidative phosphorylation inhibitor	1994	2001	26.5	low	0	0	2	2	0	0
2-aminofluorene	2			1990	1995	31.5	low	0	0	2	0	0	0
mercaptoethanol	5	alkanethiol; primary alcohol	geroprotector	1985	1993	35.0	low	0	3	2	0	0	0
5,12,20-trihydroxy-6,8,10,14-eicosatetraenoic acid	2			1984	1993	35.5	low	0	1	1	0	0	0
3,4-methylenedioxyamphetamine	2	benzodioxoles		1996	1998	27.0	low	0	0	2	0	0	0
amitrole	20	aromatic amine; triazoles	carotenoid biosynthesis inhibitor; EC 1.11.1.6 (catalase) inhibitor; herbicide	1959	2015	35.5	low	0	11	5	3	1	0
3-aminobenzamide	15	benzamides; substituted aniline	EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor	1997	2012	21.2	low	0	0	6	8	1	0
3-methylcholanthrene	1	ortho- and peri-fused polycyclic arene	aryl hydrocarbon receptor agonist; carcinogenic agent	1947	1947	77.0	low	0	1	0	0	0	0
3-nitropropionic acid	2	C-nitro compound	antimycobacterial drug; EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor; mycotoxin; neurotoxin	2015	2020	6.5	low	0	0	0	0	2	0
ro 5-4864	2			2005	2006	18.5	low	0	0	0	2	0	0
4-(2-aminoethyl)benzenesulfonylfluoride	1			2007	2007	17.0	low	0	0	0	1	0	0
homovanillic acid	4	guaiacols; monocarboxylic acid	human metabolite; mouse metabolite	1991	2006	25.8	low	0	0	3	1	0	0
4-hydroxybenzoic acid hydrazide	1	carbohydrazide; phenols		2000	2000	24.0	low	0	0	1	0	0	0
5,5-dimethyl-1-pyrroline-1-oxide	17	1-pyrroline nitrones	neuroprotective agent; spin trapping reagent	1980	2010	25.8	low	0	3	7	7	0	0
phenytoin	2	imidazolidine-2,4-dione	anticonvulsant; drug allergen; sodium channel blocker; teratogenic agent	1984	2008	28.0	low	0	1	0	1	0	0
5,8,11,14-eicosatetraynoic acid	1	long-chain fatty acid		1994	1994	30.0	low	0	0	1	0	0	0
5-hydroxydecanoate	3	medium-chain fatty acid		1997	2014	20.3	low	0	0	2	0	1	0
hydroxyindoleacetic acid	2	indole-3-acetic acids	drug metabolite; human metabolite; mouse metabolite	2014	2016	9.0	low	0	0	0	0	2	0
phenanthridone	1	lactam; phenanthridines	EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; immunosuppressive agent; mutagen	2002	2002	22.0	low	0	0	0	1	0	0
7-nitroindazole	6			1996	2012	19.8	low	0	0	1	4	1	0
8-phenyltheophylline	1			1994	1994	30.0	low	0	0	1	0	0	0
oxyquinoline	1	monohydroxyquinoline	antibacterial agent; antifungal agrochemical; antiseptic drug; iron chelator	2023	2023	1.0	low	1	0	0	0	0	1
aa 861	3	1,4-benzoquinones; acetylenic compound; primary alcohol	EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; ferroptosis inhibitor	1991	1997	29.3	low	0	0	3	0	0	0
2,2'-azobis(2-amidinopropane)	4	monoazo compound		1992	2014	23.0	low	0	0	2	1	1	0
acetaminophen	40	acetamides; phenols	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; cyclooxygenase 3 inhibitor; environmental contaminant; ferroptosis inducer; geroprotector; hepatotoxic agent; human blood serum metabolite; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic	1989	2023	14.9	low	0	1	8	13	12	6
n-acetyltryptophan	1	N-acetyl-amino acid; tryptophan derivative	metabolite	1988	1988	36.0	low	0	1	0	0	0	0
ag 127	1	nitrophenol		2004	2004	20.0	low	0	0	0	1	0	0
5-aminoisoquinolinone	4	isoquinolines		2004	2007	19.0	medium	0	0	0	4	0	0
albendazole	2	aryl sulfide; benzimidazoles; benzimidazolylcarbamate fungicide; carbamate ester	anthelminthic drug; microtubule-destabilising agent; tubulin modulator	2013	2015	10.0	low	0	0	0	0	2	0
albuterol	5	phenols; phenylethanolamines; secondary amino compound	beta-adrenergic agonist; bronchodilator agent; environmental contaminant; xenobiotic	1995	2012	19.6	low	1	0	1	3	1	0
alendronate	9	1,1-bis(phosphonic acid); primary amino compound	bone density conservation agent; EC 2.5.1.1 (dimethylallyltranstransferase) inhibitor	2004	2019	14.4	low	0	0	0	5	4	0
alprenolol	1	secondary alcohol; secondary amino compound	anti-arrhythmia drug; antihypertensive agent; beta-adrenergic antagonist; sympatholytic agent	1992	1992	32.0	low	0	0	1	0	0	0
amantadine	1	adamantanes; primary aliphatic amine	analgesic; antiparkinson drug; antiviral drug; dopaminergic agent; NMDA receptor antagonist; non-narcotic analgesic	1998	1998	26.0	low	0	0	1	0	0	0
ambroxol	2	aromatic amine		2003	2015	15.0	low	0	0	0	1	1	0
ametantrone	1			2005	2005	19.0	low	0	0	0	1	0	0
diatrizoic acid	1	acetamides; benzoic acids; organoiodine compound	environmental contaminant; radioopaque medium; xenobiotic	2000	2000	24.0	low	0	0	1	0	0	0
amifostine anhydrous	4	diamine; organic thiophosphate	antioxidant; prodrug; radiation protective agent	2008	2016	10.2	low	0	0	0	1	3	0
aminoglutethimide	3	dicarboximide; piperidones; substituted aniline	adrenergic agent; anticonvulsant; antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor	2006	2015	14.7	low	0	0	0	2	1	0
pimagedine	42	guanidines; one-carbon compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor; EC 1.4.3.4 (monoamine oxidase) inhibitor	1994	2018	19.8	low	0	0	12	22	8	0
p-aminohippuric acid	1	N-acylglycine	Daphnia magna metabolite	2020	2020	4.0	low	0	0	0	0	1	0
ampyrone	14	primary amino compound; pyrazolone	antipyretic; antirheumatic drug; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; marine xenobiotic metabolite; non-narcotic analgesic; non-steroidal anti-inflammatory drug; peripheral nervous system drug	1986	2023	21.4	low	0	3	3	4	3	1
theophylline	6	dimethylxanthine	adenosine receptor antagonist; anti-asthmatic drug; anti-inflammatory agent; bronchodilator agent; drug metabolite; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; fungal metabolite; human blood serum metabolite; immunomodulator; muscle relaxant; vasodilator agent	1985	2017	24.5	low	1	1	3	1	1	0
2-aminothiazole	1	1,3-thiazoles; primary amino compound		2003	2003	21.0	low	0	0	0	1	0	0
amiodarone	3	1-benzofurans; aromatic ketone; organoiodine compound; tertiary amino compound	cardiovascular drug	2003	2007	18.3	low	0	0	0	3	0	0
amitriptyline	2	carbotricyclic compound; tertiary amine	adrenergic uptake inhibitor; antidepressant; environmental contaminant; tropomyosin-related kinase B receptor agonist; xenobiotic	2011	2015	11.0	low	0	0	0	0	2	0
amlodipine	2	dihydropyridine; ethyl ester; methyl ester; monochlorobenzenes; primary amino compound	antihypertensive agent; calcium channel blocker; vasodilator agent	2015	2016	8.5	low	1	0	0	0	2	0
amodiaquine	4	aminoquinoline; organochlorine compound; phenols; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; drug allergen; EC 2.1.1.8 (histamine N-methyltransferase) inhibitor; non-steroidal anti-inflammatory drug; prodrug	1991	2019	16.0	low	0	0	1	1	2	0
amsacrine	1	acridines; aromatic ether; sulfonamide	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor	1992	1992	32.0	low	0	0	1	0	0	0
anethole trithione	1	methoxybenzenes		2014	2014	10.0	low	0	0	0	0	1	0
anthralin	1	anthracenes	antipsoriatic	1957	1957	67.0	low	0	1	0	0	0	0
antipyrine	15	pyrazolone	antipyretic; cyclooxygenase 3 inhibitor; environmental contaminant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic	1986	2018	15.1	low	0	1	0	7	7	0
acetovanillone	19	acetophenones; aromatic ketone; methyl ketone	antirheumatic drug; EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug; peripheral nervous system drug; plant metabolite	1994	2021	13.6	low	0	0	1	7	10	1
apraclonidine	1	dichlorobenzene; guanidines; imidazolines	alpha-adrenergic agonist; antiglaucoma drug; beta-adrenergic agonist; diagnostic agent; ophthalmology drug	1997	1997	27.0	low	0	0	1	0	0	0
arecoline	1	enoate ester; methyl ester; pyridine alkaloid; tetrahydropyridine	metabolite; muscarinic agonist	2007	2007	17.0	low	0	0	0	1	0	0
aspirin	56	benzoic acids; phenyl acetates; salicylates	anticoagulant; antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; EC 1.1.1.188 (prostaglandin-F synthase) inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; plant activator; platelet aggregation inhibitor; prostaglandin antagonist; teratogenic agent	1985	2023	17.5	low	1	1	13	20	21	1
astemizole	1	benzimidazoles; piperidines	anti-allergic agent; anticoronaviral agent; H1-receptor antagonist	1993	1993	31.0	low	0	0	1	0	0	0
atenolol	3	ethanolamines; monocarboxylic acid amide; propanolamine	anti-arrhythmia drug; antihypertensive agent; beta-adrenergic antagonist; environmental contaminant; sympatholytic agent; xenobiotic	1994	2012	20.7	low	0	0	1	1	1	0
atrazine	12	chloro-1,3,5-triazine; diamino-1,3,5-triazine	environmental contaminant; herbicide; xenobiotic	1996	2019	16.0	low	0	0	3	4	5	0
aurintricarboxylic acid	1	monohydroxybenzoic acid; quinomethanes; tricarboxylic acid	fluorochrome; histological dye; insulin-like growth factor receptor 1 antagonist	2003	2003	21.0	low	0	0	0	1	0	0
azathioprine	19	aryl sulfide; C-nitro compound; imidazoles; thiopurine	antimetabolite; antineoplastic agent; carcinogenic agent; DNA synthesis inhibitor; hepatotoxic agent; immunosuppressive agent; prodrug	1988	2021	15.2	low	3	1	3	6	8	1
azelaic acid	1	alpha,omega-dicarboxylic acid; dicarboxylic fatty acid	antibacterial agent; antineoplastic agent; dermatologic drug; plant metabolite	2005	2005	19.0	low	0	0	0	1	0	0
azelastine	2	monochlorobenzenes; phthalazines; tertiary amino compound	anti-allergic agent; anti-asthmatic drug; bronchodilator agent; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; H1-receptor antagonist; platelet aggregation inhibitor	1991	1996	30.5	low	1	0	2	0	0	0
azobenzene	1	azobenzenes		1990	1990	34.0	low	0	0	1	0	0	0
aztreonam	1			1998	1998	26.0	low	0	0	1	0	0	0
baclofen	1	amino acid zwitterion; gamma-amino acid; monocarboxylic acid; monochlorobenzenes; primary amino compound	central nervous system depressant; GABA agonist; muscle relaxant	2022	2022	2.0	low	0	0	0	0	0	1
2,2-bis(4-glycidyloxyphenyl)propane	3	diarylmethane		2003	2011	17.7	low	0	0	0	2	1	0
bendroflumethiazide	1	benzothiadiazine; sulfonamide	antihypertensive agent; diuretic	1993	1993	31.0	low	0	0	1	0	0	0
benzamide	1	benzamides		2010	2010	14.0	low	0	0	0	1	0	0
benzo(a)pyrene	9	ortho- and peri-fused polycyclic arene	carcinogenic agent; mouse metabolite	1995	2017	20.7	low	0	0	5	2	2	0
benzothiazide	2	benzothiadiazine; sulfonamide	antihypertensive agent; diuretic	2011	2012	12.5	low	0	0	0	0	2	0
butylbenzyl phthalate	1	benzyl ester		2012	2012	12.0	low	0	0	0	0	1	0
bepridil	1	pyrrolidines; tertiary amine	anti-arrhythmia drug; antihypertensive agent; calcium channel blocker; vasodilator agent	2002	2002	22.0	low	0	0	0	1	0	0
berberine	14	alkaloid antibiotic; berberine alkaloid; botanical anti-fungal agent; organic heteropentacyclic compound	antilipemic drug; antineoplastic agent; antioxidant; EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor; EC 1.21.3.3 (reticuline oxidase) inhibitor; EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor; EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor; EC 2.7.11.10 (IkappaB kinase) inhibitor; EC 3.1.1.4 (phospholipase A2) inhibitor; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor; EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; geroprotector; hypoglycemic agent; metabolite; potassium channel blocker	1993	2021	12.0	low	0	0	2	1	10	1
diminazene	2	carboxamidine; triazene derivative	antiparasitic agent; trypanocidal drug	2019	2020	4.5	low	0	0	0	0	2	0
beta-naphthoflavone	1	extended flavonoid; naphtho-gamma-pyrone; organic heterotricyclic compound	aryl hydrocarbon receptor agonist	1997	1997	27.0	low	0	0	1	0	0	0
bethanechol	2	carbamate ester; quaternary ammonium ion	muscarinic agonist	2007	2008	16.5	low	0	0	0	2	0	0
bicalutamide	1	(trifluoromethyl)benzenes; monocarboxylic acid amide; monofluorobenzenes; nitrile; sulfone; tertiary alcohol		2015	2015	9.0	low	0	0	0	0	1	0
bisbenzimidazole	1	bibenzimidazole; N-methylpiperazine	anthelminthic drug; fluorochrome	2000	2000	24.0	low	0	0	1	0	0	0
bisindolylmaleimide i	3			1993	1999	27.3	low	0	0	3	0	0	0
bisoprolol	2	secondary alcohol; secondary amine	anti-arrhythmia drug; antihypertensive agent; beta-adrenergic antagonist; sympatholytic agent	2000	2021	13.5	low	0	0	1	0	0	1
bromhexine	1	organobromine compound; substituted aniline; tertiary amino compound	mucolytic	2003	2003	21.0	low	0	0	0	1	0	0
seratrodast	1	organic molecular entity		2013	2013	11.0	low	0	0	0	0	1	0
bupivacaine	1	aromatic amide; piperidinecarboxamide; tertiary amino compound		2011	2011	13.0	low	0	0	0	0	1	0
buspirone	1	azaspiro compound; N-alkylpiperazine; N-arylpiperazine; organic heteropolycyclic compound; piperidones; pyrimidines	anxiolytic drug; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; sedative; serotonergic agonist	2014	2014	10.0	low	0	0	0	0	1	0
busulfan	2	methanesulfonate ester	alkylating agent; antineoplastic agent; carcinogenic agent; insect sterilant; teratogenic agent	2014	2022	6.0	low	0	0	0	0	1	1
cacodylic acid	1	organoarsenic compound	xenobiotic metabolite	2009	2009	15.0	low	0	0	0	1	0	0
cadralazine	1	organic molecular entity		1991	1991	33.0	low	0	0	1	0	0	0
caffeine	7	purine alkaloid; trimethylxanthine	adenosine A2A receptor antagonist; adenosine receptor antagonist; adjuvant; central nervous system stimulant; diuretic; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; environmental contaminant; food additive; fungal metabolite; geroprotector; human blood serum metabolite; mouse metabolite; mutagen; plant metabolite; psychotropic drug; ryanodine receptor agonist; xenobiotic	1995	2018	14.4	low	0	0	2	1	4	0
verapamil	9	aromatic ether; nitrile; polyether; tertiary amino compound		1989	2004	28.0	low	0	1	5	3	0	0
camphor, (+-)-isomer	2	bornane monoterpenoid; cyclic monoterpene ketone	plant metabolite	2005	2007	18.0	low	0	0	0	2	0	0
candesartan	6	benzimidazolecarboxylic acid; biphenylyltetrazole	angiotensin receptor antagonist; antihypertensive agent; environmental contaminant; xenobiotic	2003	2010	17.2	low	0	0	0	6	0	0
carbamazepine	4	dibenzoazepine; ureas	analgesic; anticonvulsant; antimanic drug; drug allergen; EC 3.5.1.98 (histone deacetylase) inhibitor; environmental contaminant; glutamate transporter activator; mitogen; non-narcotic analgesic; sodium channel blocker; xenobiotic	1993	2016	15.8	low	0	0	1	1	2	0
carbofuran	2	1-benzofurans; carbamate ester	acaricide; agrochemical; avicide; carbamate insecticide; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; nematicide	1985	2019	22.0	low	0	1	0	0	1	0
carmustine	3	N-nitrosoureas; organochlorine compound	alkylating agent; antineoplastic agent	1983	1992	37.0	low	0	2	1	0	0	0
carvedilol	17	carbazoles; secondary alcohol; secondary amino compound	alpha-adrenergic antagonist; antihypertensive agent; beta-adrenergic antagonist; cardiovascular drug; vasodilator agent	1992	2021	19.0	low	0	0	7	6	3	1
celecoxib	18	organofluorine compound; pyrazoles; sulfonamide; toluenes	cyclooxygenase 2 inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug	2000	2014	16.9	low	1	0	2	10	6	0
cetirizine	1	ether; monocarboxylic acid; monochlorobenzenes; piperazines	anti-allergic agent; environmental contaminant; H1-receptor antagonist; xenobiotic	1997	1997	27.0	low	1	0	1	0	0	0
cetyltrimethylammonium ion	10	quaternary ammonium ion		1981	2023	24.1	low	0	4	1	2	2	1
chelerythrine	2	benzophenanthridine alkaloid; organic cation	antibacterial agent; antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor	2000	2014	17.0	low	0	0	1	0	1	0
chloroquine	8	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug	1986	2022	23.1	low	0	3	2	1	1	1
chlorpheniramine	2	monochlorobenzenes; pyridines; tertiary amino compound	anti-allergic agent; antidepressant; antipruritic drug; H1-receptor antagonist; histamine antagonist; serotonin uptake inhibitor	2003	2005	20.0	low	0	0	0	2	0	0
chlorpromazine	11	organochlorine compound; phenothiazines; tertiary amine	anticoronaviral agent; antiemetic; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; phenothiazine antipsychotic drug	1957	2008	37.5	low	0	3	6	2	0	0
chlorpyrifos	7	chloropyridine; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; insecticide; xenobiotic	2009	2017	9.6	low	0	0	0	1	6	0
ciglitazone	4	aromatic ether; thiazolidinone	antineoplastic agent; insulin-sensitizing drug	2007	2010	15.5	low	0	0	0	4	0	0
cilostazol	7	lactam; tetrazoles	anticoagulant; bronchodilator agent; EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor; fibrin modulating drug; neuroprotective agent; platelet aggregation inhibitor; vasodilator agent	2006	2014	14.4	low	0	0	0	4	3	0
cimaterol	1	benzenes; nitrile		1992	1992	32.0	low	0	0	1	0	0	0
cimetidine	10	aliphatic sulfide; guanidines; imidazoles; nitrile	adjuvant; analgesic; anti-ulcer drug; H2-receptor antagonist; P450 inhibitor	1992	2010	23.5	low	0	0	5	5	0	0
eucalyptol	7			2004	2016	12.4	low	0	0	0	2	5	0
ciprofloxacin	6	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic	1998	2022	12.3	low	0	0	2	0	3	1
citalopram	1	2-benzofurans; cyclic ether; nitrile; organofluorine compound; tertiary amino compound		2019	2019	5.0	low	0	0	0	0	1	0
clenbuterol	2	amino alcohol; dichlorobenzene; ethanolamines; primary arylamine; secondary amino compound; substituted aniline	beta-adrenergic agonist; bronchodilator agent; sympathomimetic agent	2019	2022	3.5	low	0	0	0	0	1	1
clofazimine	3	monochlorobenzenes; phenazines	dye; leprostatic drug; non-steroidal anti-inflammatory drug	1987	1993	33.7	low	0	1	2	0	0	0
clonidine	5	clonidine; imidazoline		1983	2016	23.0	low	0	1	2	0	2	0
clotrimazole	5	conazole antifungal drug; imidazole antifungal drug; imidazoles; monochlorobenzenes	antiinfective agent; environmental contaminant; xenobiotic	1974	2013	22.0	low	0	1	0	2	2	0
4-cresol	2	cresol	Escherichia coli metabolite; human metabolite; uremic toxin	2003	2003	21.0	low	0	0	0	2	0	0
cypermethrin	1	aromatic ether; cyclopropanecarboxylate ester; nitrile; organochlorine compound	agrochemical; molluscicide; pyrethroid ester acaricide; pyrethroid ester insecticide	2014	2014	10.0	low	0	0	0	0	1	0
cytochalasin c	1			2003	2003	21.0	low	0	0	0	1	0	0
dapi	4	indoles	fluorochrome	2009	2020	9.8	low	0	0	0	1	3	0
dapsone	24	substituted aniline; sulfone	anti-inflammatory drug; antiinfective agent; antimalarial; leprostatic drug	1978	2022	27.7	low	0	7	9	5	2	1
2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone	1	1,4-benzoquinones	cofactor	1989	1989	35.0	low	0	1	0	0	0	0
deferoxamine	29	acyclic desferrioxamine	bacterial metabolite; ferroptosis inhibitor; iron chelator; siderophore	1984	2023	27.0	low	0	6	15	3	4	1
desipramine	1	dibenzoazepine; secondary amino compound	adrenergic uptake inhibitor; alpha-adrenergic antagonist; antidepressant; cholinergic antagonist; drug allergen; EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; H1-receptor antagonist; serotonin uptake inhibitor	2008	2008	16.0	low	0	0	0	1	0	0
eflornithine	6	alpha-amino acid; fluoroamino acid	trypanocidal drug	1991	2008	22.0	low	0	0	2	4	0	0
r 59022	1	diarylmethane		2011	2011	13.0	low	0	0	0	0	1	0
diazinon	1	organic thiophosphate; pyrimidines	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; nematicide; xenobiotic	2023	2023	1.0	low	0	0	0	0	0	1
diazoxide	7	benzothiadiazine; organochlorine compound; sulfone	antihypertensive agent; beta-adrenergic agonist; bronchodilator agent; cardiotonic drug; diuretic; K-ATP channel agonist; sodium channel blocker; sympathomimetic agent; vasodilator agent	1999	2014	15.1	low	0	0	1	2	4	0
dibenzothiophene	1	dibenzothiophenes; mancude organic heterotricyclic parent	keratolytic drug	2021	2021	3.0	low	0	0	0	0	0	1
dibutyl phthalate	2	diester; phthalate ester	EC 3.2.1.20 (alpha-glucosidase) inhibitor; environmental contaminant; metabolite; plasticiser; teratogenic agent	2014	2018	8.0	low	0	0	0	0	2	0
diclofenac	27	amino acid; aromatic amine; dichlorobenzene; monocarboxylic acid; secondary amino compound	antipyretic; drug allergen; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic	1990	2023	15.9	low	0	0	5	11	9	2
ddt	2	benzenoid aromatic compound; chlorophenylethane; monochlorobenzenes; organochlorine insecticide	bridged diphenyl acaricide; carcinogenic agent; endocrine disruptor; persistent organic pollutant	1963	2015	35.0	low	0	1	0	0	1	0
dichlorvos	1	alkenyl phosphate; dialkyl phosphate; organochlorine acaricide; organophosphate insecticide	anthelminthic drug; antibacterial agent; antifungal agent; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor	2019	2019	5.0	low	0	0	0	0	1	0
diethyl pyrocarbonate	2	acyclic carboxylic anhydride		1991	2002	27.5	low	0	0	1	1	0	0
diethylcarbamazine	1	N-carbamoylpiperazine; N-methylpiperazine		1996	1996	28.0	low	0	0	1	0	0	0
pentetic acid	6	pentacarboxylic acid	copper chelator	1999	2012	20.5	low	0	0	2	3	1	0
dihydrocytochalasin b	1			1987	1987	37.0	low	0	1	0	0	0	0
3,3'-diindolylmethane	2	indoles	antineoplastic agent; P450 inhibitor	2000	2009	19.5	low	0	0	1	1	0	0
dimaprit	1	imidothiocarbamic ester		2022	2022	2.0	low	0	0	0	0	0	1
dimethoate	2	monocarboxylic acid amide; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; insecticide; xenobiotic	2011	2017	10.0	low	0	0	0	0	2	0
diphenyleneiodonium	11	organic cation		2001	2019	14.5	low	0	0	0	7	4	0
dipyridamole	4	piperidines; pyrimidopyrimidine; tertiary amino compound; tetrol	adenosine phosphodiesterase inhibitor; EC 3.5.4.4 (adenosine deaminase) inhibitor; platelet aggregation inhibitor; vasodilator agent	1988	2012	27.8	low	0	2	1	0	1	0
dipyrithione	1	pyridinium ion		2011	2011	13.0	low	0	0	0	0	1	0
disulfiram	3	organic disulfide; organosulfur acaricide	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor; EC 3.1.1.1 (carboxylesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 5.99.1.2 (DNA topoisomerase) inhibitor; ferroptosis inducer; fungicide; NF-kappaB inhibitor	1950	2010	36.7	low	0	1	0	2	0	0
diuron	1	3-(3,4-substituted-phenyl)-1,1-dimethylurea; dichlorobenzene	environmental contaminant; mitochondrial respiratory-chain inhibitor; photosystem-II inhibitor; urea herbicide; xenobiotic	2001	2001	23.0	low	0	0	0	1	0	0
valproic acid	15	branched-chain fatty acid; branched-chain saturated fatty acid	anticonvulsant; antimanic drug; EC 3.5.1.98 (histone deacetylase) inhibitor; GABA agent; neuroprotective agent; psychotropic drug; teratogenic agent	2012	2020	8.5	low	0	0	0	0	15	0
valproic acid	14	branched-chain fatty acid; branched-chain saturated fatty acid	anticonvulsant; antimanic drug; EC 3.5.1.98 (histone deacetylase) inhibitor; GABA agent; neuroprotective agent; psychotropic drug; teratogenic agent	2012	2020	8.5	low	0	0	0	0	14	0
2,3-dimethoxy-1,4-naphthoquinone	1	1,4-naphthoquinones		2015	2015	9.0	low	0	0	0	0	1	0
donepezil	1	aromatic ether; indanones; piperidines; racemate	EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; nootropic agent	2018	2018	6.0	low	0	0	0	0	1	0
droperidol	1	aromatic ketone; benzimidazoles; organofluorine compound	anaesthesia adjuvant; antiemetic; dopaminergic antagonist; first generation antipsychotic	1993	1993	31.0	low	0	0	1	0	0	0
dup 697	1	thiophenes		2004	2004	20.0	low	0	0	0	1	0	0
ebselen	5	benzoselenazole	anti-inflammatory drug; antibacterial agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antioxidant; apoptosis inducer; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; EC 3.5.4.1 (cytosine deaminase) inhibitor; EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor; enzyme mimic; ferroptosis inhibitor; genotoxin; hepatoprotective agent; neuroprotective agent; radical scavenger	1994	2005	22.2	low	0	0	1	4	0	0
9-(2-hydroxy-3-nonyl)adenine	3			2007	2015	12.0	low	0	0	0	1	2	0
eicosa-11,14-dienoic acid	1	long-chain fatty acid		1996	1996	28.0	low	0	0	1	0	0	0
ellipticine	3	indole alkaloid; organic heterotetracyclic compound; organonitrogen heterocyclic compound; polycyclic heteroarene	antineoplastic agent; plant metabolite	2009	2020	10.7	low	0	0	0	1	2	0
embelin	4	dihydroxy-1,4-benzoquinones	antimicrobial agent; antineoplastic agent; hepatitis C protease inhibitor; plant metabolite	1991	2015	16.0	low	0	0	1	0	3	0
emodin	12	trihydroxyanthraquinone	antineoplastic agent; laxative; plant metabolite; tyrosine kinase inhibitor	2007	2022	11.2	low	0	0	0	5	6	1
endosulfan	2	cyclic sulfite ester; cyclodiene organochlorine insecticide	acaricide; agrochemical; GABA-gated chloride channel antagonist; persistent organic pollutant	2003	2009	18.0	low	0	0	0	2	0	0
epirizole	1	aromatic ether		1998	1998	26.0	low	0	0	1	0	0	0
erythrosine	36			1984	2023	18.6	low	1	3	8	11	11	3
ethacrynic acid	1	aromatic ether; aromatic ketone; dichlorobenzene; monocarboxylic acid	EC 2.5.1.18 (glutathione transferase) inhibitor; ion transport inhibitor; loop diuretic	1994	1994	30.0	low	0	0	1	0	0	0
ether	3	ether; volatile organic compound	inhalation anaesthetic; non-polar solvent; refrigerant	2006	2018	11.0	low	0	0	0	1	2	0
etidronate	1	1,1-bis(phosphonic acid)	antineoplastic agent; bone density conservation agent; chelator	1993	1993	31.0	low	0	0	1	0	0	0
famotidine	13	1,3-thiazoles; guanidines; sulfonamide	anti-ulcer drug; H2-receptor antagonist; P450 inhibitor	1993	2017	19.7	low	1	0	4	7	2	0
carbonyl cyanide p-trifluoromethoxyphenylhydrazone	1	aromatic ether; hydrazone; nitrile; organofluorine compound	ATP synthase inhibitor; geroprotector; ionophore	1986	1986	38.0	low	0	1	0	0	0	0
fenofibrate	2	aromatic ether; chlorobenzophenone; isopropyl ester; monochlorobenzenes	antilipemic drug; environmental contaminant; geroprotector; xenobiotic	2009	2010	14.5	low	0	0	0	2	0	0
fentanyl	2	anilide; monocarboxylic acid amide; piperidines	adjuvant; anaesthesia adjuvant; anaesthetic; intravenous anaesthetic; mu-opioid receptor agonist; opioid analgesic	1993	2000	27.5	low	0	0	2	0	0	0
fenthion	1	organic thiophosphate	acaricide; agrochemical; avicide; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; insecticide	2011	2011	13.0	low	0	0	0	0	1	0
fluconazole	4	conazole antifungal drug; difluorobenzene; tertiary alcohol; triazole antifungal drug	environmental contaminant; P450 inhibitor; xenobiotic	1999	2019	16.5	low	1	0	1	2	1	0
flufenamic acid	5	aromatic amino acid; organofluorine compound	antipyretic; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug	1979	2008	28.4	low	0	2	0	3	0	0
flumazenil	1	ethyl ester; imidazobenzodiazepine; organofluorine compound	antidote to benzodiazepine poisoning; GABA antagonist	2005	2005	19.0	low	0	0	0	1	0	0
flunitrazepam	1	1,4-benzodiazepinone; C-nitro compound; monofluorobenzenes	anxiolytic drug; GABAA receptor agonist; sedative	1993	1993	31.0	low	0	0	1	0	0	0
fluorouracil	40	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic	1992	2022	13.5	low	1	0	4	13	21	2
fluoxetine	5	(trifluoromethyl)benzenes; aromatic ether; secondary amino compound		2008	2019	10.0	low	0	0	0	1	4	0
flurbiprofen	6	fluorobiphenyl; monocarboxylic acid	antipyretic; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug	1998	2013	21.5	low	0	0	3	2	1	0
flutamide	7	(trifluoromethyl)benzenes; monocarboxylic acid amide	androgen antagonist; antineoplastic agent	1983	2009	22.6	low	0	1	1	5	0	0
furegrelate	2	benzofurans		1989	1990	34.5	low	0	1	1	0	0	0
furosemide	7	chlorobenzoic acid; furans; sulfonamide	environmental contaminant; loop diuretic; xenobiotic	2003	2017	14.6	low	0	0	0	4	3	0
gabapentin	3	gamma-amino acid	anticonvulsant; calcium channel blocker; environmental contaminant; xenobiotic	2003	2021	9.3	low	0	0	0	1	1	1
gabexate	5	benzoate ester		1993	2002	25.6	low	0	0	3	2	0	0
gemfibrozil	1	aromatic ether	antilipemic drug	1995	1995	29.0	low	0	0	1	0	0	0
gentamicin	15			1993	2018	17.6	low	1	0	3	7	5	0
2,5-dihydroxybenzoic acid	2	dihydroxybenzoic acid	EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; fungal metabolite; human metabolite; MALDI matrix material; mouse metabolite	1989	1999	30.0	low	0	1	1	0	0	0
gliclazide	3	N-sulfonylurea	hypoglycemic agent; insulin secretagogue; radical scavenger	2015	2020	6.0	low	0	0	0	0	3	0
glimepiride	1	sulfonamide		2011	2011	13.0	low	0	0	0	0	1	0
glutaral	7	dialdehyde	cross-linking reagent; disinfectant; fixative	1985	2016	23.3	low	0	2	1	2	2	0
glutethimide	1	piperidines		2007	2007	17.0	low	0	0	0	1	0	0
glyburide	14	monochlorobenzenes; N-sulfonylurea	anti-arrhythmia drug; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor; hypoglycemic agent	1992	2015	17.4	low	2	0	4	3	7	0
glyphosate	12	glycine derivative; phosphonic acid	agrochemical; EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitor; herbicide	2011	2023	5.7	low	0	0	0	0	6	6
go 6976	1	indolocarbazole; organic heterohexacyclic compound	EC 2.7.11.13 (protein kinase C) inhibitor	2011	2011	13.0	low	0	0	0	0	1	0
gossypol	3			1990	2013	21.0	low	0	0	1	1	1	0
guaifenesin	1	methoxybenzenes		2019	2019	5.0	low	0	0	0	0	1	0
guaifenesin	39	methoxybenzenes		1996	2021	14.1	low	3	0	7	11	18	3
guanethidine	1	azocanes; guanidines	adrenergic antagonist; antihypertensive agent; sympatholytic agent	2000	2000	24.0	low	0	0	1	0	0	0
guanidine	8	carboxamidine; guanidines; one-carbon compound		1983	2013	25.2	low	0	1	2	4	1	0
bis(2-guanidinoethyl)disulfide	1			2001	2001	23.0	low	0	0	0	1	0	0
1-(5-isoquinolinesulfonyl)-2-methylpiperazine	5	isoquinolines; N-sulfonylpiperazine	EC 2.7.11.13 (protein kinase C) inhibitor	1986	2014	19.6	low	0	1	1	0	3	0
fasudil	4	isoquinolines; N-sulfonyldiazepane	antihypertensive agent; calcium channel blocker; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; geroprotector; neuroprotective agent; nootropic agent; vasodilator agent	2000	2014	15.0	low	0	0	1	0	3	0
haloperidol	6	aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol	antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist	1992	2014	22.5	low	0	0	3	2	1	0
harmaline	1	harmala alkaloid	oneirogen	2002	2002	22.0	low	0	0	0	1	0	0
hexamethonium	8	quaternary ammonium salt		1999	2016	19.6	low	0	0	1	6	1	0
ethidium	3	phenanthridines	fluorochrome; intercalator	1995	2007	22.3	low	0	0	1	2	0	0
hydralazine	19	azaarene; hydrazines; ortho-fused heteroarene; phthalazines	antihypertensive agent; vasodilator agent	1990	2021	23.8	low	0	0	13	1	4	1
hydroxychloroquine	1	aminoquinoline; organochlorine compound; primary alcohol; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; dermatologic drug	2015	2015	9.0	low	0	0	0	0	1	0
hydroxyurea	16	one-carbon compound; ureas	antimetabolite; antimitotic; antineoplastic agent; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; genotoxin; immunomodulator; radical scavenger; teratogenic agent	1984	2019	26.7	low	1	5	6	4	1	0
hypericin	2			1999	2007	21.0	low	0	0	1	1	0	0
ibuprofen	17	monocarboxylic acid	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; environmental contaminant; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; radical scavenger; xenobiotic	1991	2015	23.1	low	0	0	9	5	3	0
lidocaine	9	benzenes; monocarboxylic acid amide; tertiary amino compound	anti-arrhythmia drug; drug allergen; environmental contaminant; local anaesthetic; xenobiotic	1985	2020	22.6	low	1	3	1	1	4	0
ifosfamide	1	ifosfamides	alkylating agent; antineoplastic agent; environmental contaminant; immunosuppressive agent; xenobiotic	2007	2007	17.0	low	0	0	0	1	0	0
imipramine	1	dibenzoazepine	adrenergic uptake inhibitor; antidepressant; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor	2010	2010	14.0	low	0	0	0	1	0	0
amrinone	2	bipyridines	EC 3.1.4.* (phosphoric diester hydrolase) inhibitor	2002	2002	22.0	low	0	0	0	2	0	0
indole-3-carbinol	2	indolyl alcohol	antineoplastic agent; plant metabolite	2005	2023	10.0	low	0	0	0	1	0	1
indomethacin	213	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic	1979	2023	20.6	low	2	10	71	89	38	5
iodoacetamide	24			1981	2016	25.0	low	0	5	6	10	3	0
iohexol	3	benzenedicarboxamide; organoiodine compound	environmental contaminant; radioopaque medium; xenobiotic	2003	2013	14.7	low	0	0	0	1	2	0
iopromide	1	dicarboxylic acid diamide; organoiodine compound	environmental contaminant; nephrotoxic agent; radioopaque medium; xenobiotic	2013	2013	11.0	low	0	0	0	0	1	0
iproniazid	1	carbohydrazide; pyridines		1991	1991	33.0	low	0	0	1	0	0	0
irsogladine	3	dichlorobenzene		2004	2008	17.3	low	0	0	0	3	0	0
1-methyl-3-isobutylxanthine	5	3-isobutyl-1-methylxanthine		1984	2005	31.0	low	0	3	0	2	0	0
isoflurane	12	organofluorine compound	inhalation anaesthetic	1991	2017	13.8	low	1	0	1	2	9	0
isoniazid	47	carbohydrazide	antitubercular agent; drug allergen	1957	2022	29.6	low	0	14	12	9	11	1
isoniazid	51	carbohydrazide	antitubercular agent; drug allergen	1957	2022	28.8	low	0	14	13	11	12	1
2-propanol	15	secondary alcohol; secondary fatty alcohol	protic solvent	1984	2012	28.7	low	0	3	9	2	1	0
isoproterenol	16	catechols; secondary alcohol; secondary amino compound	beta-adrenergic agonist; bronchodilator agent; cardiotonic drug; sympathomimetic agent	1986	2023	20.8	low	0	2	3	6	4	1
ketamine	11	cyclohexanones; monochlorobenzenes; secondary amino compound	analgesic; environmental contaminant; intravenous anaesthetic; neurotoxin; NMDA receptor antagonist; xenobiotic	1983	2021	14.0	low	0	1	1	3	5	1
ketanserin	1	aromatic ketone; organofluorine compound; piperidines; quinazolines	alpha-adrenergic antagonist; antihypertensive agent; cardiovascular drug; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; serotonergic antagonist	2007	2007	17.0	low	0	0	0	1	0	0
ketoconazole	3	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine		1983	2015	25.3	low	1	1	1	0	1	0
ketoprofen	1	benzophenones; oxo monocarboxylic acid	antipyretic; drug allergen; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; non-steroidal anti-inflammatory drug; xenobiotic	2000	2000	24.0	low	0	0	1	0	0	0
ketorolac	1	amino acid; aromatic ketone; monocarboxylic acid; pyrrolizines; racemate	analgesic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug	2009	2009	15.0	low	0	0	0	1	0	0
ketotifen	6	cyclic ketone; olefinic compound; organic heterotricyclic compound; organosulfur heterocyclic compound; piperidines; tertiary amino compound	anti-asthmatic drug; H1-receptor antagonist	1996	2007	22.7	low	0	0	3	3	0	0
kinetin	5	6-aminopurines; furans	cytokinin; geroprotector	1983	2016	21.4	low	0	1	1	1	2	0
kynurenic acid	5	monohydroxyquinoline; quinolinemonocarboxylic acid	G-protein-coupled receptor agonist; human metabolite; neuroprotective agent; nicotinic antagonist; NMDA receptor antagonist; Saccharomyces cerevisiae metabolite	2008	2022	11.2	low	0	0	0	2	2	1
lamotrigine	1	1,2,4-triazines; dichlorobenzene; primary arylamine	anticonvulsant; antidepressant; antimanic drug; calcium channel blocker; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; environmental contaminant; excitatory amino acid antagonist; geroprotector; non-narcotic analgesic; xenobiotic	2007	2007	17.0	low	0	0	0	1	0	0
lansoprazole	10	benzimidazoles; pyridines; sulfoxide	anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor	1997	2021	15.9	low	1	0	1	6	2	1
lauric acid	1	medium-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; antibacterial agent; plant metabolite	1988	1988	36.0	low	0	1	0	0	0	0
leflunomide	6	(trifluoromethyl)benzenes; isoxazoles; monocarboxylic acid amide	antineoplastic agent; antiparasitic agent; EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; hepatotoxic agent; immunosuppressive agent; non-steroidal anti-inflammatory drug; prodrug; pyrimidine synthesis inhibitor; tyrosine kinase inhibitor	1995	2015	16.3	low	0	0	1	4	1	0
letrozole	1	nitrile; triazoles	antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor	2017	2017	7.0	low	0	0	0	0	1	0
liranaftate	1	tetralins		2010	2010	14.0	low	0	0	0	1	0	0
lomefloxacin	1	fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antimicrobial agent; antitubercular agent; photosensitizing agent	2022	2022	2.0	low	0	0	0	0	0	1
loratadine	2	benzocycloheptapyridine; ethyl ester; N-acylpiperidine; organochlorine compound; tertiary carboxamide	anti-allergic agent; cholinergic antagonist; geroprotector; H1-receptor antagonist	1997	2006	22.5	low	1	0	1	1	0	0
lorglumide	1	benzamides; dicarboxylic acid monoamide; dichlorobenzene; glutamic acid derivative		2010	2010	14.0	low	0	0	0	1	0	0
losartan	9	biphenylyltetrazole; imidazoles	angiotensin receptor antagonist; anti-arrhythmia drug; antihypertensive agent; endothelin receptor antagonist	2002	2017	15.9	low	0	0	0	6	3	0
loxapine	1	dibenzooxazepine	antipsychotic agent; dopaminergic antagonist	1997	1997	27.0	low	0	0	1	0	0	0
loxoprofen	3	cyclopentanones; monocarboxylic acid	antipyretic; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug; prodrug	2010	2013	12.0	low	0	0	0	1	2	0
ly 171883	1	acetophenones; aromatic ether; phenols; tetrazoles	anti-asthmatic drug; leukotriene antagonist	1994	1994	30.0	low	0	0	1	0	0	0
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one	7	chromones; morpholines; organochlorine compound	autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector	1997	2017	14.9	low	0	0	1	2	4	0
malathion	6	diester; ethyl ester; organic thiophosphate		2014	2023	5.3	low	0	0	0	0	4	2
maprotiline	1	anthracenes		2013	2013	11.0	low	0	0	0	0	1	0
edaravone	13	pyrazolone	antioxidant; radical scavenger	2003	2022	12.4	low	0	0	0	6	6	1
mebendazole	1	aromatic ketone; benzimidazoles; carbamate ester	antinematodal drug; microtubule-destabilising agent; tubulin modulator	2015	2015	9.0	low	0	0	0	0	1	0
mechlorethamine	18	nitrogen mustard; organochlorine compound	alkylating agent	1950	2015	33.7	low	0	4	10	0	4	0
meclizine	1	diarylmethane		2013	2013	11.0	low	0	0	0	0	1	0
meclofenamic acid	2	aminobenzoic acid; organochlorine compound; secondary amino compound	analgesic; anticonvulsant; antineoplastic agent; antipyretic; antirheumatic drug; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-steroidal anti-inflammatory drug	1992	1995	30.5	low	0	0	2	0	0	0
meclofenoxate	1	monocarboxylic acid		2003	2003	21.0	low	0	0	0	1	0	0
mefenamic acid	1	aminobenzoic acid; secondary amino compound	analgesic; antipyretic; antirheumatic drug; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; non-steroidal anti-inflammatory drug; xenobiotic	2019	2019	5.0	low	0	0	0	0	1	0
memantine	4	adamantanes; primary aliphatic amine	antidepressant; antiparkinson drug; dopaminergic agent; neuroprotective agent; NMDA receptor antagonist	1998	2018	12.5	low	0	0	1	0	3	0
vitamin k 3	3	1,4-naphthoquinones; vitamin K	angiogenesis inhibitor; antineoplastic agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; human urinary metabolite; nutraceutical	2005	2021	9.0	low	0	0	0	1	1	1
meperidine	2	ethyl ester; piperidinecarboxylate ester; tertiary amino compound	antispasmodic drug; kappa-opioid receptor agonist; mu-opioid receptor agonist; opioid analgesic	1949	2008	45.5	low	0	1	0	1	0	0
2-mercaptoethylguanidine	3			2000	2000	24.0	low	0	0	3	0	0	0
mesalamine	49	amino acid; aromatic amine; monocarboxylic acid; monohydroxybenzoic acid; phenols	non-steroidal anti-inflammatory drug	1989	2022	18.3	low	0	2	15	12	17	3
metformin	11	guanidines	environmental contaminant; geroprotector; hypoglycemic agent; xenobiotic	2010	2022	8.0	low	0	0	0	1	8	2
methacrylic acid	1	alpha,beta-unsaturated monocarboxylic acid		2007	2007	17.0	low	0	0	0	1	0	0
methadone	3	benzenes; diarylmethane; ketone; tertiary amino compound		1949	2014	39.7	low	0	1	1	0	1	0
methocarbamol	1	aromatic ether; carbamate ester; secondary alcohol		2017	2017	7.0	low	0	0	0	0	1	0
methoxsalen	1	aromatic ether; psoralens	antineoplastic agent; cross-linking reagent; dermatologic drug; photosensitizing agent; plant metabolite	2019	2019	5.0	low	0	0	0	0	1	0
methoxychlor	1	organochlorine insecticide		2000	2000	24.0	low	0	0	1	0	0	0
methyl parathion	2	C-nitro compound; organic thiophosphate; organothiophosphate insecticide	acaricide; agrochemical; antifungal agent; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; genotoxin	2005	2010	16.5	low	0	0	0	2	0	0
methyl parathion	1	C-nitro compound; organic thiophosphate; organothiophosphate insecticide	acaricide; agrochemical; antifungal agent; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; genotoxin	2010	2010	14.0	low	0	0	0	1	0	0
methyl salicylate	3	benzoate ester; methyl ester; salicylates	flavouring agent; insect attractant; metabolite	2002	2020	11.0	low	0	0	0	1	2	0
methyl salicylate	4	benzoate ester; methyl ester; salicylates	flavouring agent; insect attractant; metabolite	2003	2013	14.2	low	0	0	0	1	3	0
methylphenidate	1	beta-amino acid ester; methyl ester; piperidines		2003	2003	21.0	low	0	0	0	1	0	0
metolachlor	2	aromatic amide; benzenes; ether; organochlorine compound		2010	2019	9.5	low	0	0	0	1	1	0
metoprolol	5	aromatic ether; propanolamine; secondary alcohol; secondary amino compound	antihypertensive agent; beta-adrenergic antagonist; environmental contaminant; geroprotector; xenobiotic	1996	2022	17.6	low	1	0	2	2	0	1
metronidazole	7	C-nitro compound; imidazoles; primary alcohol	antiamoebic agent; antibacterial drug; antimicrobial agent; antiparasitic agent; antitrichomonal drug; environmental contaminant; prodrug; radiosensitizing agent; xenobiotic	1993	2010	21.4	low	0	0	3	4	0	0
metyrapone	4	aromatic ketone	antimetabolite; diagnostic agent; EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor	1995	2006	24.2	low	0	0	3	1	0	0
mianserin	3	dibenzoazepine	adrenergic uptake inhibitor; alpha-adrenergic antagonist; antidepressant; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; geroprotector; H1-receptor antagonist; histamine agonist; sedative; serotonergic antagonist	2012	2015	10.7	low	0	0	0	0	3	0
miconazole	1	dichlorobenzene; ether; imidazoles		2010	2010	14.0	low	0	0	0	1	0	0
midazolam	2	imidazobenzodiazepine; monofluorobenzenes; organochlorine compound	anticonvulsant; antineoplastic agent; anxiolytic drug; apoptosis inducer; central nervous system depressant; GABAA receptor agonist; general anaesthetic; muscle relaxant; sedative	1995	2005	24.0	low	0	0	1	1	0	0
mirtazapine	3	benzazepine; tetracyclic antidepressant	alpha-adrenergic antagonist; anxiolytic drug; H1-receptor antagonist; histamine antagonist; oneirogen; serotonergic antagonist	2012	2015	10.7	low	0	0	0	0	3	0
mitoxantrone	6	dihydroxyanthraquinone	analgesic; antineoplastic agent	1992	2017	23.0	low	0	0	3	2	1	0
ml 7	2	N-sulfonyldiazepane; organoiodine compound	EC 2.7.11.18 (myosin-light-chain kinase) inhibitor	2005	2013	15.0	low	0	0	0	1	1	0
modafinil	1	monocarboxylic acid amide; sulfoxide		2020	2020	4.0	low	0	0	0	0	1	0
molsidomine	8	ethyl ester; morpholines; oxadiazole; zwitterion	antioxidant; apoptosis inhibitor; cardioprotective agent; nitric oxide donor; vasodilator agent	2001	2021	13.5	low	1	0	0	3	4	1
monodansylcadaverine	1	aminonaphthalene; primary amino compound; sulfonamide; tertiary amino compound	EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor; fluorochrome; protective agent	2000	2000	24.0	low	0	0	1	0	0	0
entinostat	7	benzamides; carbamate ester; primary amino compound; pyridines; substituted aniline	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	2008	2015	13.1	low	0	0	0	3	4	0
n-(6-aminohexyl)-1-naphthalenesulfonamide	1	naphthalenes; sulfonic acid derivative		1986	1986	38.0	low	0	1	0	0	0	0
acecainide	2	acetamides; benzamides	anti-arrhythmia drug	1995	2008	22.5	low	0	0	1	1	0	0
ethylmaleimide	9	maleimides	anticoronaviral agent; EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor; EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor; EC 2.7.1.1 (hexokinase) inhibitor	1981	2010	32.3	low	0	4	3	2	0	0
apnea	2	purine nucleoside		2004	2014	15.0	low	0	0	0	1	1	0
nafamostat	13	benzoic acids; guanidines		1997	2012	19.5	low	1	0	5	4	4	0
nalidixic acid	1	1,8-naphthyridine derivative; monocarboxylic acid; quinolone antibiotic	antibacterial drug; antimicrobial agent; DNA synthesis inhibitor	2022	2022	2.0	low	0	0	0	0	0	1
activins	2			1992	2019	18.5	low	0	0	1	0	1	0
neostigmine	1	quaternary ammonium ion	antidote to curare poisoning; EC 3.1.1.7 (acetylcholinesterase) inhibitor	2014	2014	10.0	low	0	0	0	0	1	0
ubiquinone q1	1	ubiquinones		2016	2016	8.0	low	0	0	0	0	1	0
nifedipine	8	C-nitro compound; dihydropyridine; methyl ester	calcium channel blocker; human metabolite; tocolytic agent; vasodilator agent	1988	2015	26.8	low	0	2	3	2	1	0
nimesulide	18	aromatic ether; C-nitro compound; sulfonamide	cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug	1990	2019	19.8	low	0	0	7	7	4	0
nimodipine	2	2-methoxyethyl ester; C-nitro compound; dicarboxylic acids and O-substituted derivatives; diester; dihydropyridine; isopropyl ester	antihypertensive agent; calcium channel blocker; cardiovascular drug; vasodilator agent	1999	2015	17.0	low	0	0	1	0	1	0
nitroglycerin	10	nitroglycerol	explosive; muscle relaxant; nitric oxide donor; prodrug; tocolytic agent; vasodilator agent; xenobiotic	1989	2014	24.4	low	1	1	6	2	1	0
nomifensine	1	isoquinolines	dopamine uptake inhibitor	2006	2006	18.0	low	0	0	0	1	0	0
norfloxacin	2	fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antibacterial drug; DNA synthesis inhibitor; environmental contaminant; xenobiotic	2019	2021	4.0	low	0	0	0	0	1	1
ns 1619	1	(trifluoromethyl)benzenes; benzimidazoles; phenols	potassium channel opener	2012	2012	12.0	low	0	0	0	0	1	0
n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	10	aromatic ether; C-nitro compound; sulfonamide	antineoplastic agent; cyclooxygenase 2 inhibitor	1997	2016	18.4	low	0	0	2	6	2	0
ofloxacin	3	3-oxo monocarboxylic acid; N-arylpiperazine; N-methylpiperazine; organofluorine compound; oxazinoquinoline		2008	2022	8.7	low	1	0	0	1	1	1
olprinone	2	bipyridines		2004	2005	19.5	low	0	0	0	2	0	0
omeprazole	31	aromatic ether; benzimidazoles; pyridines; sulfoxide		1994	2021	16.6	low	1	0	5	15	10	1
ondansetron	1	carbazoles		2011	2011	13.0	low	0	0	0	0	1	0
oxonic acid	1	1,3,5-triazines; monocarboxylic acid		2013	2013	11.0	low	0	0	0	0	1	0
oxatomide	1	benzimidazoles; diarylmethane; N-alkylpiperazine	anti-allergic agent; anti-inflammatory agent; geroprotector; H1-receptor antagonist; serotonergic antagonist	1993	1993	31.0	low	0	0	1	0	0	0
oxidopamine	8	benzenetriol; catecholamine; primary amino compound	drug metabolite; human metabolite; neurotoxin	1984	2022	19.5	low	0	1	2	2	2	1
oxybutynin	1	acetylenic compound; carboxylic ester; racemate; tertiary alcohol; tertiary amino compound	antispasmodic drug; calcium channel blocker; local anaesthetic; muscarinic antagonist; muscle relaxant; parasympatholytic	2012	2012	12.0	low	0	0	0	0	1	0
aminosalicylic acid	2	aminobenzoic acid; phenols	antitubercular agent	1989	1994	32.5	low	0	1	1	0	0	0
quinone	16	1,4-benzoquinones	cofactor; human xenobiotic metabolite; mouse metabolite	1986	2009	28.4	low	0	4	7	5	0	0
fenclonine	1	phenylalanine derivative		2005	2005	19.0	low	0	0	0	1	0	0

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
2019 Novel Coronavirus Disease	38	2020	2023	2.3	low	2	0	0	0	4	34
47,XX,+21	11	1975	2015	31.4	low	0	6	1	2	2	0
A-V Dissociation	2	2004	2006	19.0	low	0	0	0	2	0	0
Abdominal Abscess	1	2006	2006	18.0	low	0	0	0	1	0	0
Abdominal Aortic Aneurysm	22	1995	2020	14.6	low	2	0	3	8	11	0
Abdominal Compartment Syndrome	2	2013	2015	10.0	low	0	0	0	0	2	0
Abdominal Cramps	3	1997	2016	17.0	low	0	0	1	1	1	0
Abdominal Injuries	1	2007	2007	17.0	low	0	0	0	1	0	0
Abdominal Obesity	2	2011	2013	12.0	low	1	0	0	0	2	0
Abdominal Pain	7	2003	2017	15.0	low	0	0	0	4	3	0
Aberrant Crypt Foci	2	2013	2018	8.5	low	0	0	0	0	2	0
Abnormalities, Autosome	33	1977	2016	27.3	low	1	7	14	9	3	0
Abnormalities, Cardiovascular	1	1957	1957	67.0	low	0	1	0	0	0	0
Abnormalities, Congenital	1	1955	1955	69.0	low	0	1	0	0	0	0
Abnormalities, Drug-Induced	2	2007	2013	14.0	low	0	0	0	1	1	0
Abnormalities, Multiple	1	1983	1983	41.0	low	0	1	0	0	0	0
Abnormalities, Skin	2	1991	2021	18.0	low	0	0	1	0	0	1
Abnormality, Heart	3	2000	2018	16.7	low	2	0	1	1	1	0
Abnormality, Torsion	2	2001	2013	17.0	low	0	0	0	1	1	0
Abortion, Habitual	2	1999	2023	13.0	low	0	0	1	0	0	1
Abortion, Recurrent	2	1999	2023	13.0	low	0	0	1	0	0	1
Abortion, Spontaneous	2	2004	2020	12.0	low	0	0	0	1	1	0
Abortion, Tubal	2	2004	2020	12.0	low	0	0	0	1	1	0
Abscess	10	1963	2020	29.4	low	0	6	0	1	3	0
Abscess, Abdominal	1	2006	2006	18.0	low	0	0	0	1	0	0
Abscess, Amebic	2	2016	2019	6.5	low	0	0	0	0	2	0
Abscess, Amebic, Hepatic	4	2008	2020	8.8	low	0	0	0	1	3	0
Abscess, Hepatic	3	1977	2011	35.0	low	0	2	0	0	1	0
Abscess, Intracranial, Subdural	1	2018	2018	6.0	low	0	0	0	0	1	0
Abscess, Peritonsillar	1	2002	2002	22.0	low	0	0	0	1	0	0
Abscess, Pulmonary	1	2014	2014	10.0	low	0	0	0	0	1	0
Absence of Brain, Congenital	1	1987	1987	37.0	low	0	1	0	0	0	0
Absence Seizure	6	1950	2021	18.8	low	0	1	0	0	4	1
Absence Status	2	1997	2010	20.5	low	0	0	1	1	0	0
Acanthamoeba Keratitis	1	2001	2001	23.0	low	0	0	0	1	0	0
Acanthamoeba Meningoencephalitis	1	2019	2019	5.0	low	0	0	0	0	1	0
Acariasis	2	2014	2017	8.5	low	0	0	0	0	2	0
Acatalasemia	4	1976	1990	41.2	low	0	3	1	0	0	0
Acetonemia	1	2000	2000	24.0	low	0	0	1	0	0	0
Ache	56	1998	2023	11.4	low	3	0	1	17	30	8
Achondroplasia	1	1998	1998	26.0	low	0	0	1	0	0	0
Achondroplasia, Severe, With Developmental Delay And Acanthosis Nigricans	1	1998	1998	26.0	low	0	0	1	0	0	0
Acid Aspiration Syndrome	16	1993	2014	21.1	low	0	0	8	5	3	0
Acid beta-Glucosidase Deficiency	1	1976	1976	48.0	low	0	1	0	0	0	0
Acid-Base Imbalance	2	1999	2012	18.5	low	0	0	1	0	1	0
Acidosis	5	1999	2016	18.2	low	0	0	2	1	2	0
Acidosis, Diabetic	1	2016	2016	8.0	low	0	0	0	0	1	0
Acidosis, Respiratory	1	2009	2009	15.0	low	0	0	0	1	0	0
Acinetobacter Infections	2	2006	2014	14.0	low	0	0	0	1	1	0
Acne	4	1996	2021	13.8	low	0	0	1	1	1	1
Acne Inversa	2	2021	2021	3.0	low	0	0	0	0	0	2
Acne Vulgaris	4	1996	2021	13.8	low	0	0	1	1	1	1
Acquired Autoimmune Hemolytic Anemia	2	2000	2008	20.0	low	0	0	1	1	0	0
Acquired Immune Deficiency Syndrome	6	1987	2009	28.8	low	0	2	2	2	0	0
Acquired Immunodeficiency Syndrome	6	1987	2009	28.8	low	0	2	2	2	0	0
Acquired Laryngeal Stenosis	2	2016	2019	6.5	low	0	0	0	0	2	0
Acquired Storage Pool Disease	1	2007	2007	17.0	low	0	0	0	1	0	0
Acquired-Immune Deficiency Syndrome Dementia Complex	1	2010	2010	14.0	low	0	0	0	1	0	0
Acrania	2	1987	2017	22.0	low	0	1	0	0	1	0
Acromegaly	1	2010	2010	14.0	low	0	0	0	1	0	0
Actinobacillus Infections	7	2005	2017	14.9	low	1	0	0	6	1	0
Actinomycetales Infections	1	2012	2012	12.0	low	0	0	0	0	1	0
Active Hyperemia	7	1988	2017	21.9	low	0	1	1	3	2	0
Acute Autoimmune Neuropathy	1	2000	2000	24.0	low	0	0	1	0	0	0
Acute Bacterial Prostatitis	4	1999	2007	22.0	low	0	0	2	2	0	0
Acute Biphenotypic Leukemia	9	1990	2018	15.4	low	0	0	2	2	5	0
Acute Brain Injuries	47	1992	2022	16.1	low	1	0	12	15	18	2
Acute Confusional Senile Dementia	40	1996	2023	13.0	low	2	0	3	15	17	5
Acute Coronary Syndrome	73	2005	2023	11.9	low	9	0	0	25	47	1
Acute Disease	505	1976	2023	20.0	low	6	36	127	218	116	8
Acute Edematous Pancreatitis	267	1987	2023	15.4	low	0	2	30	125	103	7
Acute Febrile Neutrophilic Dermatosis	7	1998	2020	12.6	low	0	0	1	2	4	0
Acute Hemolytic Transfusion Reaction	3	1997	2012	22.0	low	0	0	2	0	1	0
Acute Hepatic Failure	11	2003	2022	10.2	low	0	0	0	2	8	1
Acute Hypercapnic Respiratory Failure	14	1989	2019	18.9	low	2	1	2	8	3	0
Acute Ischemic Stroke	3	2023	2023	1.0	low	0	0	0	0	0	3
Acute Kidney Failure	112	1988	2023	13.2	low	0	1	11	30	64	6
Acute Kidney Injury	112	1988	2023	13.2	low	0	1	11	30	64	6
Acute Kidney Tubular Necrosis	3	2004	2016	15.3	low	0	0	0	2	1	0
Acute Liver Injury, Drug-Induced	90	1990	2022	11.6	low	0	0	5	21	58	6
Acute Lung Injury	413	2003	2023	9.7	low	1	0	0	56	337	20
Acute Lymphoid Leukemia	69	1988	2021	24.6	low	1	4	41	16	6	2
Acute Mesenteric Arterial Embolus	5	2011	2022	7.4	low	0	0	0	0	4	1
Acute Myelogenous Leukemia	234	1975	2023	29.2	low	1	107	55	41	27	4
Acute Necrotizing Pancreatitis	67	1999	2016	15.1	low	0	0	2	42	23	0
Acute Onset Vascular Dementia	1	2016	2016	8.0	low	0	0	0	0	1	0
Acute Pain	3	2012	2018	8.7	low	1	0	0	0	3	0
Acute Post-operative Pain	2	2007	2015	13.0	low	0	0	0	1	1	0
Acute Post-Traumatic Stress Disorder	1	2015	2015	9.0	low	0	0	0	0	1	0
Acute Promyelocytic Leukemia	58	1988	2023	25.5	low	0	10	32	5	7	4
Acute Respiratory Distress Syndrome	175	1983	2022	19.9	low	2	9	46	88	29	3
Acute Rheumatic Fever	1	2020	2020	4.0	low	0	0	0	0	1	0
Acute Yellow Atrophy	1	2004	2004	20.0	low	0	0	0	1	0	0
Acute-On-Chronic Liver Failure	1	2021	2021	3.0	low	0	0	0	0	0	1
Acute-On-Chronic Liver Failure (ACLF)	1	2021	2021	3.0	low	0	0	0	0	0	1
Acute-Phase Reaction	18	1990	2020	19.8	low	1	0	3	14	1	0
Adamantiades-Behcet Disease	9	1980	2023	25.7	low	0	3	2	2	1	1
ADDH	1	2014	2014	10.0	low	0	0	0	0	1	0
Addiction, Opioid	1	2001	2001	23.0	low	0	0	0	1	0	0
Addison's Anemia	3	1962	1990	43.3	low	0	1	2	0	0	0
Adenitis	1	1985	1985	39.0	low	0	1	0	0	0	0
Adenitis, Salivary Gland	2	1992	2008	24.0	low	0	0	1	1	0	0
Adenocarcinoma	30	1984	2023	16.9	low	1	3	2	13	9	3
Adenocarcinoma, Basal Cell	30	1984	2023	16.9	low	1	3	2	13	9	3
Adenofibroma	2	1984	1988	38.0	low	0	2	0	0	0	0
Adenohypophyseal Diseases	1	2013	2013	11.0	low	0	0	0	0	1	0
Adenoma	9	1981	2017	20.3	low	0	1	2	2	4	0
Adenoma, Basal Cell	9	1981	2017	20.3	low	0	1	2	2	4	0
Adenoma, Prostatic	3	1999	2018	14.3	low	0	0	1	0	2	0
Adenomatous Polyposis Coli	2	2005	2015	14.0	low	0	0	0	1	1	0
Adenomatous Polyposis Coli, Familial	2	2005	2015	14.0	low	0	0	0	1	1	0
Adenomatous Polyps	1	1999	1999	25.0	low	0	0	1	0	0	0
Adenosis of Breast	2	1984	1988	38.0	low	0	2	0	0	0	0
Adenoviridae Infections	3	2007	2022	8.7	low	0	0	0	1	1	1
Adenovirus Infections	3	2007	2022	8.7	low	0	0	0	1	1	1
Adhesions, Tissue	7	1995	2020	16.9	low	0	0	2	3	2	0
Adipocere	5	1988	2018	21.8	low	0	2	0	1	2	0
Adjuvant Arthritis	46	1997	2023	12.1	low	0	0	2	16	24	4
Adnexitis	2	1994	2010	22.0	low	1	0	1	1	0	0
Adolescent Gynecomastia	1	2003	2003	21.0	low	0	0	0	1	0	0
Adolescent Obesity	4	2013	2018	8.0	low	1	0	0	0	4	0
ADPKD	1	2013	2013	11.0	low	0	0	0	0	1	0
Adrenal Cancer	2	1988	2015	22.5	low	0	1	0	0	1	0
Adrenal Gland Hypofunction	3	2007	2013	14.7	low	0	0	0	2	1	0
Adrenal Insufficiency	3	2007	2013	14.7	low	0	0	0	2	1	0
Adult Fanconi Syndrome	1	2007	2007	17.0	low	0	0	0	1	0	0
Adult Periodontitis	20	2008	2019	11.3	low	5	0	0	6	14	0
Adult-Onset Dystonias	1	2020	2020	4.0	low	0	0	0	0	1	0
Adult-Onset Still Disease	2	2013	2019	8.0	low	0	0	0	0	2	0
Adverse Drug Event	5	1950	2019	24.2	low	1	1	0	2	2	0
Aerobic Glycolysis, Oncologic	1	2021	2021	3.0	low	0	0	0	0	0	1
Affective Disorders	2	2004	2016	14.0	low	0	0	0	1	1	0
Affective Psychosis, Bipolar	2	2015	2016	8.5	low	0	0	0	0	2	0
Afibrinogenemia	1	2006	2006	18.0	low	0	0	0	1	0	0
Afibrinogenemia, Congenital	1	2006	2006	18.0	low	0	0	0	1	0	0
African Lymphoma	14	1983	2023	23.4	low	2	2	8	2	1	1
African Sleeping Sickness	2	1953	2012	41.5	low	0	1	0	0	1	0
African Tick-Bite Fever	1	2020	2020	4.0	low	0	0	0	0	1	0
Agammaglobulinemia	5	1976	2009	33.4	low	0	2	2	1	0	0
Age-Related Memory Disorders	8	2009	2021	8.6	low	0	0	0	1	6	1
Age-Related Osteoporosis	1	2011	2011	13.0	low	0	0	0	0	1	0
Agenesis of Hemidiaphragm	1	2001	2001	23.0	low	0	0	0	1	0	0
Aggressive Periodontitis	9	1987	2015	22.1	low	0	1	4	1	3	0
Aging	77	1959	2022	19.6	low	4	7	15	32	20	3
Agnogenic Myeloid Metaplasia	10	1977	2016	30.0	low	0	6	1	0	3	0
Agranulocytosis	28	1975	2014	31.6	low	1	11	11	4	2	0
Agricultural Worker Disease	1	2008	2008	16.0	low	0	0	0	1	0	0
AIDS Dementia Complex	1	2010	2010	14.0	low	0	0	0	1	0	0
AIDS-Related Complex	2	1991	1993	32.0	low	0	0	2	0	0	0
AIDS-Related Opportunistic Infections	1	1993	1993	31.0	low	0	0	1	0	0	0
AIDS, Simian	1	2018	2018	6.0	low	0	0	0	0	1	0
Air Embolism	2	2010	2012	13.0	low	0	0	0	1	1	0
Airflow Obstruction, Chronic	70	2001	2023	12.7	low	11	0	0	32	35	3
Airway Hyper-Responsiveness	12	1994	2016	17.9	low	0	0	4	3	5	0
Airway Obstruction	8	1989	2021	18.2	low	1	1	2	2	2	1
Airway Remodeling	4	2011	2016	10.5	low	0	0	0	0	4	0
Akinetic-Rigid Variant of Huntington Disease	3	2005	2020	9.0	low	0	0	0	1	2	0
Albers-Schoenberg Disease	1	1982	1982	42.0	low	0	1	0	0	0	0
Albinism	1	1964	1964	60.0	low	0	1	0	0	0	0
Albuminuria	4	2004	2023	11.8	low	0	0	0	2	1	1
Alcaptonuria	1	1999	1999	25.0	low	0	0	1	0	0	0
Alcohol Abuse	10	1986	2019	19.5	low	0	2	2	1	5	0
Alcohol Drinking	12	1991	2023	15.8	low	1	0	4	3	4	1
Alcohol-Induced Disorders	1	2016	2016	8.0	low	0	0	0	0	1	0
Alcohol-Induced Peripheral Neuropathy	1	2012	2012	12.0	low	0	0	0	0	1	0
Alcoholic Cirrhosis	5	1980	2016	22.2	low	0	2	0	1	2	0
Alcoholic Fatty Liver	2	2008	2017	11.5	low	0	0	0	1	1	0
Alcoholic Hepatitis	1	1988	1988	36.0	low	0	1	0	0	0	0
Alcoholic Intoxication	9	1989	2014	18.2	low	0	1	1	4	3	0
Alcoholic Liver Diseases	2	2001	2012	17.5	low	0	0	0	1	1	0
Alcoholic Pancreatitis	6	2000	2012	17.8	low	0	0	1	4	1	0
Alcoholism	10	1986	2019	19.5	low	0	2	2	1	5	0
Aldrich Syndrome	2	1995	2011	21.0	low	0	0	1	0	1	0
Algodystrophic Syndrome	2	1998	2016	17.0	low	0	0	1	0	1	0
Alkalosis	1	2009	2009	15.0	low	0	0	0	1	0	0
Alkaptonuria	1	1999	1999	25.0	low	0	0	1	0	0	0
Allergic Alveolitis, Extrinsic	3	1992	1999	29.7	low	0	0	3	0	0	0
Allergic Angiitis	90	1990	2023	14.1	low	0	0	16	25	32	17
Allergic Bronchopulmonary Aspergilloses	2	1997	1997	27.0	low	0	0	2	0	0	0
Allergic Conjunctivitis	3	2000	2012	18.7	low	0	0	1	1	1	0
Allergic Contact Dermatitis	6	2004	2022	11.3	low	0	0	0	2	3	1
Allergic Cutaneous Angiitis	25	1990	2013	22.0	low	0	0	11	11	3	0
Allergic Encephalomyelitis	14	2001	2019	11.7	low	0	0	0	5	9	0
Allergic Reaction	24	1954	2017	21.0	low	0	1	8	6	9	0
Allergic Rhinitis	3	2013	2019	9.0	low	1	0	0	0	3	0
Allergy, Drug	5	1990	2008	25.0	low	0	0	3	2	0	0
Allergy, Food	9	1999	2020	16.7	low	0	0	1	6	2	0
Allergy, Milk	4	2007	2010	15.2	low	1	0	0	4	0	0
Allergy, Peanut	1	2004	2004	20.0	low	0	0	0	1	0	0
Allergy, Wheat	3	2010	2021	10.3	low	0	0	0	2	0	1
Allodynia	70	1998	2022	11.2	low	0	0	2	18	47	3
Alloxan Diabetes	67	1958	2022	13.7	low	0	4	2	17	39	5
Alopecia Areata	1	2021	2021	3.0	low	0	0	0	0	0	1
Alopecia Circumscripta	1	2021	2021	3.0	low	0	0	0	0	0	1
Alpers Diffuse Degeneration of Cerebral Gray Matter with Hepatic Cirrhosis	1	2000	2000	24.0	low	0	0	1	0	0	0
alpha 1-Antitrypsin Deficiency	12	1992	2020	19.3	low	2	0	4	4	4	0
alpha-Galactosidase A Deficiency	2	1976	2006	33.0	low	0	1	0	1	0	0
alpha-Lipoprotein Deficiency Disease, Familial	1	2014	2014	10.0	low	0	0	0	0	1	0
Alport Syndrome	1	1977	1977	47.0	low	0	1	0	0	0	0
ALS - Amyotrophic Lateral Sclerosis	4	2002	2023	12.5	low	1	0	0	2	1	1
Altered Level of Consciousness	1	2014	2014	10.0	low	0	0	0	0	1	0
Altidudinal Hemianopia	1	2012	2012	12.0	low	0	0	0	0	1	0
Altitude Hypoxia	2	2011	2019	9.0	low	0	0	0	0	2	0
Altitude Sickness	2	2011	2019	9.0	low	0	0	0	0	2	0
Alveolar Bone Atrophy	40	2005	2023	11.3	low	0	0	0	12	27	1
Alveolar Echinococcosis, Hepatic	2	1987	2001	30.0	low	0	1	0	1	0	0
Alveolitis, Extrinsic Allergic	3	1992	1999	29.7	low	0	0	3	0	0	0
Alveolitis, Fibrosing	74	1978	2022	18.1	low	1	7	11	26	29	1
Alzheimer Disease	40	1996	2023	13.0	low	2	0	3	15	17	5
Amaurosis	2	1997	2015	18.0	low	0	0	1	0	1	0
Ambulation Disorders, Neurologic	1	2017	2017	7.0	low	0	0	0	0	1	0
Amebiasis	2	2016	2019	6.5	low	0	0	0	0	2	0
Amebiasis, Intestinal	1	2008	2008	16.0	low	0	0	0	1	0	0
Amentia	4	2013	2018	9.0	low	0	0	0	0	4	0
American Trypanosomiasis	7	1983	2022	16.1	low	1	2	0	1	2	2
Amnionitis	10	2008	2019	9.9	low	1	0	0	1	9	0
Amyloid Deposits	2	1999	2004	22.5	low	0	0	1	1	0	0
Amyloid Neuropathies, Familial	1	2014	2014	10.0	low	0	0	0	0	1	0
Amyloid Neuropathy Type 1	1	2014	2014	10.0	low	0	0	0	0	1	0
Amyloidosis	5	1976	2020	26.0	low	0	2	0	2	1	0
Amyotonia Congenita	2	1978	2000	35.0	low	0	1	1	0	0	0
Amyotrophic Lateral Sclerosis	4	2002	2023	12.5	low	1	0	0	2	1	1
Anaphylactic Reaction	8	1954	2017	25.6	low	0	1	3	3	1	0
Anaphylaxis	8	1954	2017	25.6	low	0	1	3	3	1	0
Anaplasma Infection	1	2017	2017	7.0	low	0	0	0	0	1	0
Anaplastic Large-Cell Lymphoma	3	1996	2018	19.0	low	0	0	1	1	1	0
Anasarca	365	1988	2024	15.4	low	1	3	66	107	177	12
Anastomotic Leak	1	2012	2012	12.0	low	0	0	0	0	1	0
ANCA-Associated Vasculitides	422	2009	2023	6.2	medium	11	0	0	16	267	139
Ancylostomiasis	1	2011	2011	13.0	low	0	0	0	0	1	0
Androgen-Independent Prostatic Cancer	1	2021	2021	3.0	low	0	0	0	0	0	1
Anemia	16	1952	2019	34.1	low	1	7	1	2	6	0
Anemia, Aplastic	7	1953	2004	38.9	low	0	4	2	1	0	0
Anemia, Fanconi	2	1998	2006	22.0	low	0	0	1	1	0	0
Anemia, Hemolytic	4	1998	2018	16.2	low	0	0	1	1	2	0
Anemia, Hemolytic, Acquired	4	1998	2018	16.2	low	0	0	1	1	2	0
Anemia, Hemolytic, Autoimmune	2	2000	2008	20.0	low	0	0	1	1	0	0
Anemia, Hypochromic	12	1962	1994	40.5	low	0	9	3	0	0	0
Anemia, Hypoplastic	7	1953	2004	38.9	low	0	4	2	1	0	0
Anemia, Iron-Deficiency	3	2011	2021	8.0	low	0	0	0	0	2	1
Anemia, Macrocytic	2	1977	1990	40.5	low	0	1	1	0	0	0
Anemia, Megaloblastic	4	1977	2004	33.5	low	0	1	2	1	0	0
Anemia, Refractory	3	1988	2011	27.3	low	0	1	1	0	1	0
Anemia, Refractory, with Excess of Blasts	4	1988	2002	30.8	low	0	1	2	1	0	0
Anemia, Sickle Cell	17	1976	2022	16.8	low	2	1	4	4	7	1
Anemia, Sideroblastic	2	1988	2002	29.0	low	0	1	0	1	0	0
Anemia, Splenic	2	1982	1993	36.5	low	0	1	1	0	0	0
Anemias, Iron-Deficiency	3	2011	2021	8.0	low	0	0	0	0	2	1
Anesthesia	14	1990	2017	18.9	low	1	0	4	6	4	0
Aneuploid	1	2002	2002	22.0	low	0	0	0	1	0	0
Aneurysm	2	2009	2021	9.0	low	0	0	0	1	0	1
Aneurysm, Anterior Cerebral Artery	10	2003	2023	8.9	low	1	0	0	2	5	3
Aneurysm, Arteriovenous	3	2007	2014	12.7	low	0	0	0	1	2	0
Aneurysm, Bacterial	1	2013	2013	11.0	low	0	0	0	0	1	0
Aneurysm, Ruptured	5	2000	2021	10.4	low	1	0	1	0	3	1
Aneurysm, Thoracic Aortic	3	2003	2020	14.0	low	1	0	0	2	1	0
Angiitis	395	1985	2023	21.2	low	4	1	148	196	41	9
Angiitis, Central Nervous System	7	1998	2022	14.9	low	0	0	1	3	2	1
Angina at Rest	22	1996	2014	17.5	low	3	0	2	15	5	0
Angina Pectoris	22	1995	2015	15.3	low	2	0	1	11	10	0
Angina Pectoris with Normal Coronary Arteriogram	1	2009	2009	15.0	low	1	0	0	1	0	0
Angina Pectoris, Stable	6	2013	2017	8.8	low	2	0	0	0	6	0
Angina Pectoris, Variant	1	1996	1996	28.0	low	0	0	1	0	0	0
Angina, Stable	6	2013	2017	8.8	low	2	0	0	0	6	0
Angina, Unstable	22	1996	2014	17.5	low	3	0	2	15	5	0
Angioedema	1	2008	2008	16.0	low	0	0	0	1	0	0
Angioedema, Hereditary	1	2021	2021	3.0	low	0	0	0	0	0	1
Angioedemas, Hereditary	1	2021	2021	3.0	low	0	0	0	0	0	1
Angiofollicular Lymph Hyperplasia	1	1998	1998	26.0	low	0	0	1	0	0	0
Angiogenesis, Pathologic	37	2003	2023	11.3	low	1	0	0	9	25	3
Angiogranuloma	1	2013	2013	11.0	low	0	0	0	0	1	0
Angioma	1	1999	1999	25.0	low	0	0	1	0	0	0
Angiomyxoma	1	2005	2005	19.0	low	0	0	0	1	0	0
Angioneurotic Edema	1	2008	2008	16.0	low	0	0	0	1	0	0
Angiospasm, Intracranial	3	2000	2012	16.7	low	0	0	1	1	1	0
Angiostrongylus Infections	6	1997	2008	22.2	low	0	0	3	3	0	0
Angle's Classification	2	2014	2014	10.0	low	0	0	0	0	2	0
Angor Pectoris	22	1995	2015	15.3	low	2	0	1	11	10	0
Anguilluliasis	3	2008	2018	11.7	low	0	0	0	1	2	0
Animal Mammary Carcinoma	4	2000	2021	9.0	low	0	0	1	0	2	1
Anisakiasis	2	2006	2011	15.5	low	0	0	0	1	1	0
Ankylosing Spondylarthritis	8	1991	2021	14.8	low	1	0	2	2	2	2
Anochlesia	2	2013	2018	8.5	low	0	0	0	0	2	0
Anorectal Diseases	2	2003	2009	18.0	low	0	0	0	2	0	0
Anorexia	1	1996	1996	28.0	low	0	0	1	0	0	0
Anosmia	1	2021	2021	3.0	low	0	0	0	0	0	1
Anovulation	1	1986	1986	38.0	low	0	1	0	0	0	0
Anoxemia	60	1981	2022	17.2	low	3	1	14	19	24	2
Anoxia-Ischemia, Brain	9	2002	2015	15.8	low	0	0	0	6	3	0
Anoxia, Brain	1	2018	2018	6.0	low	0	0	0	0	1	0
Anterior Cerebral Circulation Infarction	22	2001	2017	14.5	low	0	0	0	12	10	0
Anterior Cervical Pain	1	2015	2015	9.0	low	0	0	0	0	1	0
Anterior Choroidal Artery Infarction	41	1991	2023	17.3	low	0	0	9	20	10	2
Anterior Circulation Transient Ischemic Attack	37	1991	2023	21.4	low	0	0	15	18	3	1
Anterior Fascicular Block	1	2004	2004	20.0	low	0	0	0	1	0	0
Anterior Ischemic Optic Neuropathy	1	2010	2010	14.0	low	0	0	0	1	0	0
Anthrax	1	2017	2017	7.0	low	0	0	0	0	1	0
Anti-GBM Disease	36	1990	2023	19.4	low	0	0	15	11	6	4
Anti-Glomerular Basement Membrane Disease	36	1990	2023	19.4	low	0	0	15	11	6	4
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	422	2009	2023	6.2	medium	11	0	0	16	267	139
Antibiotic-Associated Colitis	12	1984	2014	24.1	low	0	1	6	3	2	0
Antibody Deficiency Syndrome	16	1976	2017	30.6	low	0	4	10	0	2	0
Anus Prolapse	1	2018	2018	6.0	low	0	0	0	0	1	0
Anxiety	10	2006	2019	11.0	low	0	0	0	2	8	0
Anxiety Disorders	4	2004	2015	13.0	low	0	0	0	2	2	0
Anxiety Neuroses	4	2004	2015	13.0	low	0	0	0	2	2	0
Aortic Aneurysm, Abdominal	22	1995	2020	14.6	low	2	0	3	8	11	0
Aortic Aneurysm, Ruptured	7	1995	2018	18.6	low	0	0	2	3	2	0
Aortic Aneurysm, Thoracic	3	2003	2020	14.0	low	1	0	0	2	1	0
Aortic Arteritis, Giant Cell	8	2000	2023	9.4	low	0	0	1	2	1	4
Aortic Coarctation	1	2007	2007	17.0	low	0	0	0	1	0	0
Aortic Diseases	11	1994	2021	16.8	low	1	0	2	6	2	1
Aortic Dissection	1	2020	2020	4.0	low	1	0	0	0	1	0
Aortic Incompetence	1	2021	2021	3.0	low	0	0	0	0	0	1
Aortic Stenosis	4	2013	2022	5.2	low	0	0	0	0	2	2
Aortic Valve Disease 1	1	2014	2014	10.0	low	0	0	0	0	1	0
Aortic Valve Insufficiency	1	2021	2021	3.0	low	0	0	0	0	0	1
Aortic Valve Stenosis	4	2013	2022	5.2	low	0	0	0	0	2	2
Aortitis	2	2000	2007	20.5	low	0	0	1	1	0	0
Aortitis Syndrome	1	2020	2020	4.0	low	0	0	0	0	1	0
Aphthae	3	1987	2014	21.0	low	1	1	0	1	1	0
Aplasia Pure Red Cell	1	2004	2004	20.0	low	0	0	0	1	0	0
Apnea	2	2004	2014	15.0	low	0	0	0	1	1	0
Apnea, Obstructive Sleep	12	2007	2023	8.3	low	2	0	0	1	9	2
Apnea, Sleep	1	2012	2012	12.0	low	0	0	0	0	1	0
Apolipoprotein B-100, Familial Defective	3	2008	2020	11.0	low	1	0	0	1	2	0
Apoplexy	55	2001	2023	9.5	low	1	0	0	13	33	9
Appendicitis	4	1984	2020	15.5	low	0	1	0	0	3	0
Arachnidism	1	2012	2012	12.0	low	0	0	0	0	1	0
Arachnoid Membrane Inflammation	1	2017	2017	7.0	low	0	0	0	0	1	0
Arachnoidal Cerebellar Sarcoma, Circumscribed	1	1989	1989	35.0	low	0	1	0	0	0	0
ARC	2	1991	1993	32.0	low	0	0	2	0	0	0
Arrhythmia	19	1994	2019	18.9	low	0	0	6	9	4	0
Arrhythmias, Cardiac	19	1994	2019	18.9	low	0	0	6	9	4	0
ARSA Deficiency	1	1976	1976	48.0	low	0	1	0	0	0	0
Arsenic Encephalopathy	2	2003	2010	17.5	low	0	0	0	2	0	0
Arterial Diseases, Carotid	18	2000	2018	13.1	low	2	0	1	9	8	0
Arterial Diseases, Cerebral	1	2016	2016	8.0	low	0	0	0	0	1	0
Arterial Inflammation	20	1988	2023	24.2	low	1	1	13	3	1	2
Arterial Obstructive Diseases	27	1991	2020	21.9	low	0	0	14	9	4	0
Arterial Occlusive Diseases	27	1991	2020	21.9	low	0	0	14	9	4	0
Arteriosclerosis	75	1981	2008	24.0	low	1	3	34	38	0	0
Arteriosclerosis Obliterans	1	2013	2013	11.0	low	0	0	0	0	1	0
Arteriosclerosis, Coronary	125	1996	2022	12.7	low	8	0	3	53	65	4
Arteriovenous Malformations, Cerebral	3	2004	2008	18.0	low	0	0	0	3	0	0
Arthralgia	2	2017	2020	5.5	low	0	0	0	0	2	0
Arthritides, Bacterial	4	1992	2021	15.8	low	0	0	1	1	1	1
Arthritis	31	1989	2020	16.4	low	0	1	8	11	11	0
Arthritis, Degenerative	13	1985	2023	15.5	low	2	1	3	1	7	1
Arthritis, Gouty	4	2013	2022	4.8	low	0	0	0	0	2	2
Arthritis, Juvenile	8	1979	2021	19.5	low	0	1	2	2	2	1
Arthritis, Juvenile Chronic	8	1979	2021	19.5	low	0	1	2	2	2	1
Arthritis, Post-Infectious	2	1983	1999	33.0	low	0	1	1	0	0	0
Arthritis, Psoriatic	6	1996	2022	11.2	low	0	0	2	0	1	3
Arthritis, Reactive	2	1983	1999	33.0	low	0	1	1	0	0	0
Arthritis, Rheumatoid	113	1975	2023	20.5	low	1	12	42	20	30	9
Arthropathies	6	1984	2013	20.2	low	0	1	1	1	3	0
Arthus Phenomenon	10	1986	2016	24.5	low	0	1	6	1	2	0
Asbestosis	4	2002	2007	20.2	low	0	0	0	4	0	0
Ascites	15	1999	2015	19.1	low	0	0	3	10	2	0
Ascorbic Acid Deficiency	2	1977	2000	35.5	low	0	1	1	0	0	0
Aseptic Meningitis	1	2007	2007	17.0	low	0	0	0	1	0	0
Asialia	3	2008	2018	12.3	low	0	0	0	2	1	0
Aspergillosis	17	1983	2023	14.5	low	0	2	2	4	5	4
Aspergillosis, Allergic Bronchopulmonary	2	1997	1997	27.0	low	0	0	2	0	0	0
Aspergillus Infection	17	1983	2023	14.5	low	0	2	2	4	5	4
Asphyxia	2	2013	2019	8.0	low	0	0	0	0	2	0
Asphyxia Neonatorum	3	2007	2019	10.7	low	0	0	0	1	2	0
Aspiration, Meconium	3	2005	2007	18.3	low	0	0	0	3	0	0
Aspiration, Respiratory	2	2008	2009	15.5	low	0	0	0	2	0	0
Asthenia	1	2011	2011	13.0	low	0	0	0	0	1	0
Asthma	143	1978	2023	20.5	low	9	8	48	49	34	4
Asthma, Bronchial	143	1978	2023	20.5	low	9	8	48	49	34	4
Asthma, Exercise-Induced	2	1997	2023	14.0	low	1	0	1	0	0	1
Asthma, Occupational	1	2015	2015	9.0	low	0	0	0	0	1	0
Asthmatic Crisis	1	1999	1999	25.0	low	0	0	1	0	0	0
Astrocytoma, Grade IV	2	1994	2022	16.0	low	0	0	1	0	0	1
Astrocytosis	7	2007	2020	10.9	low	0	0	0	2	5	0
Asymptomatic Colonization	2	2018	2020	5.0	low	0	0	0	0	2	0
Asymptomatic Conditions	3	2012	2021	7.0	low	0	0	0	0	2	1
Asystole	8	2000	2023	15.5	low	1	0	1	4	2	1
Ataxia Telangiectasia	1	1995	1995	29.0	low	0	0	1	0	0	0
Ataxia Telangiectasia Syndrome	1	1995	1995	29.0	low	0	0	1	0	0	0
Ataxias, Hereditary	1	2019	2019	5.0	low	0	0	0	0	1	0
Atelectasis	3	2004	2007	18.3	low	0	0	0	3	0	0
Atheroembolism	3	2002	2006	20.3	low	0	0	0	3	0	0
Atherogenesis	161	2005	2023	11.2	low	3	0	0	64	84	13
Atheroma	40	2010	2023	8.2	low	2	0	0	2	34	4
Atherosclerosis	161	2005	2023	11.2	low	3	0	0	64	84	13
Atherosclerotic Parkinsonism	1	2010	2010	14.0	low	0	0	0	1	0	0
Athlete's Foot	2	1986	1986	38.0	low	0	2	0	0	0	0
ATLL	8	1989	2004	26.4	low	0	1	5	2	0	0
Atopic Hypersensitivity	14	1983	2009	24.4	low	1	1	5	8	0	0
Atresia, Biliary	2	1987	1993	34.0	low	0	1	1	0	0	0
Atrial Fibrillation	21	2005	2023	7.9	low	2	0	0	3	12	6
Atrial Remodeling	2	2016	2020	6.0	low	0	0	0	0	2	0
Atrial Septal Defect	1	1993	1993	31.0	low	0	0	1	0	0	0
Atrioventricular Block	1	2021	2021	3.0	low	0	0	0	0	0	1
Atrioventricular Conduction Block	1	2021	2021	3.0	low	0	0	0	0	0	1
Atrioventricular Nodal Re-Entrant Tachycardia	1	2002	2002	22.0	low	0	0	0	1	0	0
Atrophic Muscular Disorders	1	2008	2008	16.0	low	0	0	0	1	0	0
Atrophy	12	2004	2023	9.3	low	1	0	0	4	4	4
Atrophy, Muscle	4	2006	2008	16.5	low	0	0	0	4	0	0
Attachment Loss, Periodontal	15	1996	2017	16.7	low	2	0	2	9	4	0
Attention Deficit Disorder with Hyperactivity	1	2014	2014	10.0	low	0	0	0	0	1	0
Atypical Chronic Myeloid Leukemia	2	2007	2016	12.5	low	0	0	0	1	1	0
Atypical Ductal Hyperplasia	1	1984	1984	40.0	low	0	1	0	0	0	0
Atypical Endometrial Hyperplasia	1	1982	1982	42.0	low	0	1	0	0	0	0
Atypical Mycobacterial Infection, Disseminated	2	2018	2023	3.5	low	0	0	0	0	1	1
Auditory Vertigo	1	1998	1998	26.0	low	0	0	1	0	0	0
Aura	4	2007	2022	7.8	low	0	0	0	1	2	1
Auricular Fibrillation	21	2005	2023	7.9	low	2	0	0	3	12	6
Autism Spectrum Disorder	1	2021	2021	3.0	low	0	0	0	0	0	1
Autoimmune Chronic Hepatitis	8	1998	2020	15.9	low	0	0	2	3	3	0
Autoimmune Diabetes	22	1988	2021	16.3	low	0	3	3	4	9	3
Autoimmune Disease	117	1982	2023	20.1	low	1	6	39	41	27	4
Autoimmune Diseases	117	1982	2023	20.1	low	1	6	39	41	27	4
Autoimmune Thrombocytopenia	2	2016	2022	5.0	low	0	0	0	0	1	1
Autoimmune Thyroiditis	26	1988	2015	22.5	low	0	4	7	10	5	0
Autolysis	1	1995	1995	29.0	low	0	0	1	0	0	0
Autonomic Dysfunction, Paraneoplastic	1	2016	2016	8.0	low	0	0	0	0	1	0
Autosomal Chromosome Disorders	6	1982	2016	31.5	low	0	3	2	0	1	0
Autosomal Dominant Juvenile Parkinson Disease	6	2005	2022	8.8	low	0	0	0	1	4	1
Autosomal Recessive Chronic Granulomatous Disease	104	1975	2020	36.5	low	0	70	22	8	4	0
Avian Flu	1	2015	2015	9.0	low	0	0	0	0	1	0
Avian Sarcoma	1	1947	1947	77.0	low	0	1	0	0	0	0
Azoospermia	1	2023	2023	1.0	low	1	0	0	0	0	1
B cepacia Infection	3	2001	2012	16.7	low	0	0	0	2	1	0
B Virus Infection	3	1995	2014	20.7	low	0	0	1	1	1	0
B-Cell Chronic Lymphocytic Leukemia	8	1988	2022	18.4	low	1	1	1	4	1	1
B-Cell Leukemia	3	2004	2021	10.0	low	0	0	0	1	1	1
B-Cell Lymphoma	6	1991	2005	26.2	low	0	0	4	2	0	0
B. burgdorferi Infection	1	2014	2014	10.0	low	0	0	0	0	1	0
B16 Melanoma	5	1990	2021	16.6	low	0	0	2	0	2	1
Bacillaceae Infections	1	2006	2006	18.0	low	0	0	0	1	0	0
Bacillus anthracis Infection	1	2017	2017	7.0	low	0	0	0	0	1	0
Bacteremia	24	1992	2023	20.5	low	1	0	13	3	6	2
Bacterial Conjunctivitides	2	2000	2011	18.5	low	0	0	1	0	1	0
Bacterial Disease	89	1976	2023	24.2	low	5	27	21	20	13	8
Bacterial Endocarditides	1	2010	2010	14.0	low	0	0	0	1	0	0
Bacterial Endocarditides, Subacute	1	2001	2001	23.0	low	0	0	0	1	0	0
Bacterial Eye Infections	23	1995	2020	18.2	low	0	0	4	14	5	0
Bacterial Infections	89	1976	2023	24.2	low	5	27	21	20	13	8
Bacterial Infections, Gram-Negative	28	1997	2022	10.9	low	2	0	1	5	20	2
Bacterial Infections, Gram-Positive	7	2007	2019	11.1	low	0	0	0	3	4	0
Bacterial Meningitides	6	2000	2019	17.3	low	0	0	3	1	2	0
Bacterial Pneumonia	40	1996	2022	15.7	low	2	0	5	20	13	2
Bacterial Skin Diseases	1	2014	2014	10.0	low	0	0	0	0	1	0
Bacterial Vaginitides	2	2011	2011	13.0	low	0	0	0	0	2	0
Bacteriuria	2	1995	2020	16.5	low	0	0	1	0	1	0
Bacteroidaceae Infections	3	2000	2013	16.7	low	1	0	1	1	1	0
Bancroftian Elephantiasis	1	1996	1996	28.0	low	0	0	1	0	0	0
Bang Disease	1	2004	2004	20.0	low	0	0	0	1	0	0
Barrett Epithelium	6	1995	2014	18.8	low	0	0	1	3	2	0
Barrett Esophagus	6	1995	2014	18.8	low	0	0	1	3	2	0
Basedow Disease	41	1989	2018	21.4	low	0	1	14	20	6	0
Basophilic Leukemia, Acute	2	2001	2003	22.0	low	0	0	0	2	0	0
Becker Muscular Dystrophy	4	2000	2023	9.2	low	1	0	1	0	2	1
Bed Sores	4	2000	2019	16.2	low	0	0	1	2	1	0
Behavior Disorders	1	2011	2011	13.0	low	0	0	0	0	1	0
Behcet Syndrome	9	1980	2023	25.7	low	0	3	2	2	1	1
Bends	4	2002	2013	14.5	low	0	0	0	1	3	0
Benign Cerebellar Neoplasms	3	1989	2005	27.3	low	0	1	1	1	0	0
Benign Meningeal Neoplasms	1	2007	2007	17.0	low	0	0	0	1	0	0
Benign Monoclonal Gammopathies	2	2002	2020	13.0	low	0	0	0	1	1	0
Benign Mucosal Pemphigoid	1	2014	2014	10.0	low	0	0	0	0	1	0
Benign Neoplasms	127	1947	2023	16.0	low	4	16	10	30	47	24
Benign Neoplasms, Brain	7	1997	2019	14.4	low	0	0	1	2	4	0
Benign Paroxysmal Peritonitis	3	1983	2021	24.0	low	0	1	1	0	0	1
Benign Psychomotor Epilepsy, Childhood	1	2020	2020	4.0	low	0	0	0	0	1	0
Berger Disease	18	1992	2022	16.9	low	0	0	5	6	6	1
Beriberi	1	1964	1964	60.0	low	0	1	0	0	0	0
Besnier-Boeck Disease	8	1980	2022	24.0	low	0	4	0	1	1	2
Besnoitiasis	4	1984	2016	17.0	low	0	1	0	0	3	0
Bewilderment	1	2004	2004	20.0	low	0	0	0	1	0	0
Bicuspid Aortic Valve Disease	1	2014	2014	10.0	low	0	0	0	0	1	0
Bilateral Deafness	4	1997	2011	20.0	low	0	0	1	2	1	0
Bilateral Headache	9	2003	2023	8.7	low	0	0	0	3	3	3
Bilateral Nasal Obstruction	3	1998	2008	22.0	low	0	0	2	1	0	0
Bile Duct Cancer	3	2006	2023	7.7	low	1	0	0	1	1	1
Bile Duct Neoplasms	3	2006	2023	7.7	low	1	0	0	1	1	1
Bile Duct Obstruction	30	1980	2021	19.0	low	0	2	6	15	6	1
Bile Duct Obstruction, Extrahepatic	4	1996	2016	17.0	low	0	0	1	2	1	0
Bile Duct Obstruction, Intrahepatic	4	2003	2014	14.0	low	0	0	0	2	2	0
Bilharziasis	2	1981	1996	35.5	low	0	1	1	0	0	0
Biliary Atresia	2	1987	1993	34.0	low	0	1	1	0	0	0
Biliary Cirrhosis	6	1998	2007	20.3	low	0	0	1	5	0	0
Biliary Tract Cancer	2	2000	2015	16.5	low	0	0	1	0	1	0
Biliary Tract Diseases	2	1993	2021	17.0	low	0	0	1	0	0	1
Biliary Tract Neoplasms	2	2000	2015	16.5	low	0	0	1	0	1	0
Bilirubin Encephalopathy	1	2009	2009	15.0	low	0	0	0	1	0	0
Binge Alcohol Consumption	1	2018	2018	6.0	low	0	0	0	0	1	0
Biological Clock Disturbances	1	2008	2008	16.0	low	0	0	0	1	0	0
Bipolar Disorder	2	2015	2016	8.5	low	0	0	0	0	2	0
Birth Weight	8	1995	2022	10.2	low	0	0	1	0	6	1
Bisphosphonate Osteonecrosis	1	2014	2014	10.0	low	0	0	0	0	1	0
Black Death	2	1987	2016	22.5	low	0	1	0	0	1	0
Black Fever	5	1982	2011	22.6	low	0	1	0	3	1	0
Bladder Cancer	9	1992	2014	21.8	low	0	0	4	4	1	0
Bladder Diseases	1	2007	2007	17.0	low	0	0	0	1	0	0

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Assessment of reactive oxygen species production in cultured equine skeletal myoblasts in response to conditions of anoxia followed by reoxygenation with or without exposure to peroxidases.
American journal of veterinary research, , Volume: 73, Issue:3, 2012

Neutrophil priming by hypoxic preconditioning protects against epithelial barrier damage and enteric bacterial translocation in intestinal ischemia/reperfusion.
Laboratory investigation; a journal of technical methods and pathology, , Volume: 92, Issue:5, 2012

Exercise increases the frequency of circulating hematopoietic progenitor cells, but reduces hematopoietic colony-forming capacity.
Stem cells and development, , Nov-01, Volume: 21, Issue:16, 2012

Nitrosative and oxidative stresses contribute to post-ischemic liver injury following severe hemorrhagic shock: the role of hypoxemic resuscitation.
PloS one, , Volume: 7, Issue:3, 2012

Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism.
Circulation research, , Mar-02, Volume: 110, Issue:5, 2012

Assessment of uric acid and lipid peroxidation in serum and urine after hypoxia-ischemia neonatal in rats.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 32, Issue:1, 2011

An experimental research on chronic intermittent hypoxia leading to liver injury.
Sleep & breathing = Schlaf & Atmung, , Volume: 15, Issue:3, 2011

Cysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice.
Anesthesiology, , Volume: 115, Issue:4, 2011

Hypobaric hypoxia preconditioning attenuates acute lung injury during high-altitude exposure in rats via up-regulating heat-shock protein 70.
Clinical science (London, England : 1979), , Volume: 121, Issue:5, 2011

Hypoxemic resuscitation from hemorrhagic shock prevents lung injury and attenuates oxidative response and IL-8 overexpression.
Free radical biology & medicine, , Jan-15, Volume: 50, Issue:2, 2011

Hypoxic exercise training reduces senescent T-lymphocyte subsets in blood.
Brain, behavior, and immunity, , Volume: 25, Issue:2, 2011

Clinical significance of a myeloperoxidase gene polymorphism and inducible nitric oxide synthase expression in cirrhotic patients with hepatopulmonary syndrome.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, , Volume: 30, Issue:4, 2010

Therapeutic window for cinnamophilin following oxygen-glucose deprivation and transient focal cerebral ischemia.
Experimental neurology, , Volume: 217, Issue:1, 2009

L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats.
American journal of physiology. Renal physiology, , Volume: 296, Issue:5, 2009

Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice.
American journal of physiology. Lung cellular and molecular physiology, , Volume: 294, Issue:2, 2008

Effect of inhalation of nebulized NO donor substance on acute hypoxic lung injury in newborn piglets.
Chinese medical journal, , Sep-05, Volume: 121, Issue:17, 2008

Endothelial nitric oxide synthase mediates protective effects of hypoxic preconditioning in lungs.
Respiratory physiology & neurobiology, , Mar-15, Volume: 155, Issue:3, 2007

Inhibition of neutrophil elastase attenuates gut mucosal injury evoked by acute alveolar hypoxia in rabbits.
Shock (Augusta, Ga.), , Volume: 28, Issue:1, 2007

Hypoxia aggravates lipopolysaccharide-induced lung injury.
Clinical and experimental immunology, , Volume: 141, Issue:2, 2005

Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation.
Shock (Augusta, Ga.), , Volume: 23, Issue:6, 2005

Exposure to hypoxia results in uneven pulmonary blood flow distribution prior to pulmonary edema.
The Tokai journal of experimental and clinical medicine, , Volume: 30, Issue:4, 2005

Matrix metalloproteinase inhibition decreases ischemia-reperfusion injury after lung transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, , Volume: 4, Issue:1, 2004

Effect of a short-term hypoxic treatment followed by re-aeration on free radicals level and antioxidative enzymes in lupine roots.
Plant physiology and biochemistry : PPB, , Volume: 42, Issue:3, 2004

The role of PKCdelta and PKCepsilon in the neonatal rat colon in response to hypoxia challenge.
Pediatric research, , Volume: 55, Issue:1, 2004

Reperfusion of ischemic corporal tissue: physiologic and biochemical changes in an animal model of ischemic priapism.
Urology, , Volume: 62, Issue:4, 2003

Induction of apoptosis following blunt chest trauma.
Shock (Augusta, Ga.), , Volume: 20, Issue:6, 2003

Roles of ischemia and hypoxia and the molecular pathogenesis of post-burn cardiac shock.
Burns : journal of the International Society for Burn Injuries, , Volume: 29, Issue:8, 2003

Fluorescence imaging of lipid peroxidation in isolated rat lungs during nonhypoxic lung ischemia.
Free radical biology & medicine, , Mar-15, Volume: 34, Issue:6, 2003

Delivery of a non-potassium modified maintenance solution to enhance myocardial protection in stressed neonatal hearts: a new approach.
The Journal of thoracic and cardiovascular surgery, , Volume: 123, Issue:1, 2002

Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia requires 5-lipoxygenase in mice.
Circulation research, , Apr-27, Volume: 88, Issue:8, 2001

Acute hypoxia and reoxygenation impairs exhaled nitric oxide release and pulmonary mechanics.
The Journal of thoracic and cardiovascular surgery, , Volume: 119, Issue:5, 2000

Role of nitric oxide in hypoxia-induced changes in newborn rats.
Biology of the neonate, , Volume: 78, Issue:3, 2000

L-arginine, prostaglandin, and white cell filtration equally improve myocardial protection in stressed neonatal hearts.
The Journal of thoracic and cardiovascular surgery, , Volume: 118, Issue:4, 1999

Dose dependency of L-arginine in neonatal myocardial protection: the nitric oxide paradox.
The Journal of thoracic and cardiovascular surgery, , Volume: 118, Issue:4, 1999

G-CSF instillation into rat lungs mediates neutrophil recruitment, pulmonary edema, and hypoxia.
Journal of leukocyte biology, , Volume: 63, Issue:2, 1998

Oxygen radical generation and enzymatic properties of mitochondria in hypoxia/reoxygenation.
Arzneimittel-Forschung, , Volume: 48, Issue:6, 1998

[Functional activity of peripheral blood neutrophils of rats during combined effects of hypoxia, hypercapnia and cooling].
Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine, , Volume: 31, Issue:6, 1997

The role of neutrophils in the production of hypoxic-ischemic brain injury in the neonatal rat.
Pediatric research, , Volume: 41, Issue:5, 1997

[Predictive information of basic indices of biochemical status of a man in evaluating the tolerance to acute hypoxia].
Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine, , Volume: 30, Issue:5, 1996

The effect of high dose antenatal vitamin E on hypoxia-induced changes in newborn rats.
Pediatric research, , Volume: 38, Issue:5, 1995

The role of endogenous nitric oxide and platelet-activating factor in hypoxia-induced intestinal injury in rats.
Gastroenterology, , Volume: 106, Issue:2, 1994

Endotoxin priming followed by high altitude causes pulmonary edema in rats.
Journal of applied physiology (Bethesda, Md. : 1985), , Volume: 74, Issue:4, 1993

Protective effect of gangliosides on myocardial hypoxic damage in the rat.
European journal of pharmacology, , May-30, Volume: 198, Issue:1, 1991

Effect of sodium azide on hydrogen peroxide production by zymosan-activated human neutrophils.
Inflammation, , Volume: 14, Issue:3, 1990

Monocyte-mediated antibody-dependent cell-mediated cytotoxicity: the role of the metabolic burst.
Blood, , Volume: 58, Issue:2, 1981

The role of myeloperoxidase in the pathogenesis of postoperative adhesions.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , Volume: 17, Issue:4

[The significance of the hypoxic factor in adaptation to the action of ionizing radiation as a result of the accident at the Chernobyl Atomic Electric Power Station].
Likars'ka sprava, , Issue:9-12

S-nitrosylation of peroxiredoxin 1 contributes to viability of lung epithelial cells during Bacillus anthracis infection.
Biochimica et biophysica acta. General subjects, , Volume: 1861, Issue:1 Pt A, 2017

Chronic colitis-induced visceral pain is associated with increased anxiety during quiescent phase.
American journal of physiology. Gastrointestinal and liver physiology, , 06-01, Volume: 316, Issue:6, 2019

Effect of moderate or high intensity exercise on hypothyroid rats exposed to acute stress.
The Journal of sports medicine and physical fitness, , Volume: 57, Issue:12, 2017

Lower Urinary Tract Symptoms, Depression, Anxiety and Systemic Inflammatory Factors in Men: A Population-Based Cohort Study.
PloS one, , Volume: 10, Issue:10, 2015

Microbiota and host determinants of behavioural phenotype in maternally separated mice.
Nature communications, , Jul-28, Volume: 6, 2015

Time-dependent analysis of nociception and anxiety-like behavior in rats submitted to persistent inflammation of the temporomandibular joint.
Physiology & behavior, , Feb-10, Volume: 125, 2014

Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats.
Behavioral and brain functions : BBF, , Dec-17, Volume: 9, 2013

[Change of serum myeloperoxidase and lipoxin A4 level in coronary heart disease patients with anxiety and/or depression].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, , Volume: 38, Issue:4, 2013

Sex-dependent control of murine emotional-affective behaviour in health and colitis by peptide YY and neuropeptide Y.
British journal of pharmacology, , Volume: 163, Issue:6, 2011

Experimental gastritis in mice enhances anxiety in a gender-related manner.
Neuroscience, , Dec-12, Volume: 150, Issue:3, 2007

Colitis-induced oxidative damage of the colon and skeletal muscle is ameliorated by regular exercise in rats: the anxiolytic role of exercise.
Experimental physiology, , Volume: 91, Issue:5, 2006

Lower Urinary Tract Symptoms, Depression, Anxiety and Systemic Inflammatory Factors in Men: A Population-Based Cohort Study.
PloS one, , Volume: 10, Issue:10, 2015

Protective effect of exercise and sildenafil on acute stress and cognitive function.
Physiology & behavior, , Nov-01, Volume: 151, 2015

Stress-induced multiple organ damage in rats is ameliorated by the antioxidant and anxiolytic effects of regular exercise.
Cell biochemistry and function, , Volume: 28, Issue:6, 2010

The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future.
BMC psychiatry, , Aug-18, Volume: 4, 2004

Aortic coarctation hypertension induces fibroblast growth factor-2 immunoreactivity in the stimulated nucleus tractus solitarii.
Journal of molecular histology, , Volume: 38, Issue:4, 2007

What is the meaning of ANCA positivity in IgG4-related disease?
Rheumatology (Oxford, England), , 08-02, Volume: 60, Issue:8, 2021

Relationship of serum inflammatory biomarkers with plaque inflammation assessed by FDG PET/CT: the dal-PLAQUE study.
JACC. Cardiovascular imaging, , Volume: 6, Issue:10, 2013

Race-specific associations of myeloperoxidase with atherosclerosis in a population-based sample: the Dallas Heart Study.
Atherosclerosis, , Volume: 219, Issue:2, 2011

Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 30, Issue:5, 2010

Tezosentan reduces the renal injury induced by abdominal aortic ischemia-reperfusion in rats.
The Journal of surgical research, , Volume: 157, Issue:1, 2009

Low coronary driving pressure is associated with subendocardial remodelling and left ventricular dysfunction in aortocaval fistula.
Clinical and experimental pharmacology & physiology, , Volume: 34, Issue:11, 2007

CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1.
Circulation, , Mar-27, Volume: 115, Issue:12, 2007

Expression of human myeloperoxidase by macrophages promotes atherosclerosis in mice.
Circulation, , May-31, Volume: 111, Issue:21, 2005

Effect of inhibitors of myeloperoxidase on the development of aortic atherosclerosis in an animal model.
Experimental gerontology, , Volume: 40, Issue:3, 2005

Long-term probucol treatment reverses the severity of myocardial injury in watanabe heritable hyperlipidemic rabbits.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 17, Issue:11, 1997

Nitric oxide (endothelium-derived relaxing factor) attenuates revascularization-induced lung injury.
The Journal of surgical research, , Volume: 57, Issue:1, 1994

Rapid aortic and mitral valve thickening and regurgitation with complete atrioventricular block due to myeloperoxidase anti-neutrophil cytoplasmic antibody-associated vasculitis.
Journal of echocardiography, , Volume: 19, Issue:3, 2021

Systemic inflammation and oxidative stress contribute to acute kidney injury after transcatheter aortic valve implantation.
Cardiology journal, , Volume: 29, Issue:5, 2022

Development of aortic valve stenosis in myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis with renal involvement.
PloS one, , Volume: 16, Issue:1, 2021

NETosis is associated with the severity of aortic stenosis: Links with inflammation.
International journal of cardiology, , 07-01, Volume: 286, 2019

Myeloperoxidase and progression of aortic valve stenosis in patients undergoing hemodialysis.
The Journal of heart valve disease, , Volume: 22, Issue:5, 2013

Acute alcohol intoxication prolongs neuroinflammation without exacerbating neurobehavioral dysfunction following mild traumatic brain injury.
Journal of neurotrauma, , Feb-15, Volume: 31, Issue:4, 2014

Neutrophil tolerance to oxidative stress induced by hypoxia/reoxygenation.
Free radical research, , Volume: 38, Issue:9, 2004

Markers of neutrophil activation and extracellular traps formation are predictive of appendicitis in mice and humans: a pilot study.
Scientific reports, , 10-26, Volume: 10, Issue:1, 2020

The Use of Delta Neutrophil Index and Myeloperoxidase Index for Predicting Acute Complicated Appendicitis in Children.
PloS one, , Volume: 11, Issue:2, 2016

Can new inflammatory markers improve the diagnosis of acute appendicitis?
World journal of surgery, , Volume: 38, Issue:11, 2014

[Cytochemical indicators of phagocytes in children with destructive appendicitis].
Khirurgiia, , Issue:12, 1984

Prognostic Role of Elevated Myeloperoxidase in Patients with Acute Coronary Syndrome: A Systemic Review and Meta-Analysis.
Mediators of inflammation, , Volume: 2019, 2019

Immune Modulation of Cardiac Arrhythmias.
Circulation research, , 06-23, Volume: 121, Issue:1, 2017

[no title available]
Applied physics. B, Lasers and optics, , Volume: 122, Issue:12, 2016

The usefulness of myeloperoxidase in prediction of in-hospital mortality in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention.
Clinical laboratory, , Volume: 58, Issue:1-2, 2012

Prognostic value of myeloperoxidase in coronary artery disease: comparison of unstable and stable angina patients.
Coronary artery disease, , Volume: 21, Issue:3, 2010

Protection against in vivo focal myocardial ischemia/reperfusion injury-induced arrhythmias and apoptosis by hesperidin.
Free radical research, , Volume: 43, Issue:9, 2009

Pravastatin inhibits arrhythmias induced by coronary artery ischemia in anesthetized rats.
Journal of pharmacological sciences, , Volume: 103, Issue:3, 2007

Gender specific effect of progesterone on myocardial ischemia/reperfusion injury in rats.
Life sciences, , Jun-27, Volume: 81, Issue:3, 2007

Nitric oxide and prostacyclin pathways: an integrated mechanism that limits myocardial infarction progression in anaesthetized rats.
Pharmacological research, , Volume: 53, Issue:4, 2006

New sialyl-Lewis-X analogues antagonize leukocyte-induced ischemia-reperfusion arrhythmia--a mapping study.
The Thoracic and cardiovascular surgeon, , Volume: 52, Issue:2, 2004

The isolated blood-perfused rat heart: an inappropriate model for the study of ischaemia- and infarction-related ventricular fibrillation.
British journal of pharmacology, , Volume: 137, Issue:7, 2002

The nitroderivative of aspirin, NCX 4016, reduces infarct size caused by myocardial ischemia-reperfusion in the anesthetized rat.
The Journal of pharmacology and experimental therapeutics, , Volume: 297, Issue:1, 2001

Magnolol reduces myocardial ischemia/reperfusion injury via neutrophil inhibition in rats.
European journal of pharmacology, , Jun-22, Volume: 422, Issue:1-3, 2001

Possible role of cardiac mast cells in norepinephrine-induced myocardial preconditioning.
Methods and findings in experimental and clinical pharmacology, , Volume: 21, Issue:4, 1999

Possible role of adrenergic component and cardiac mast cell degranulation in preconditioning-induced cardioprotection.
Pharmacological research, , Volume: 40, Issue:2, 1999

Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart.
The American journal of pathology, , Volume: 152, Issue:5, 1998

Cardiac mast cell stabilization and cardioprotective effect of ischemic preconditioning in isolated rat heart.
Journal of cardiovascular pharmacology, , Volume: 31, Issue:5, 1998

Formation of nitric oxide, superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury in rats.
The American journal of physiology, , Volume: 272, Issue:5 Pt 2, 1997

Effect of duration of ischaemia on reduction of myocardial infarct size by inhibition of neutrophil accumulation using an anti-CD18 monoclonal antibody.
British journal of pharmacology, , Volume: 111, Issue:4, 1994

Myeloperoxidase and coronary arterial disease: from research to clinical practice.
Arquivos brasileiros de cardiologia, , Volume: 91, Issue:1, 2008

Heparin, myeloperoxidase, and atherosclerosis: a new focus on an old drug.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, , Volume: 13, Issue:2, 2007

Localization of nitration and chlorination sites on apolipoprotein A-I catalyzed by myeloperoxidase in human atheroma and associated oxidative impairment in ABCA1-dependent cholesterol efflux from macrophages.
The Journal of biological chemistry, , Jan-07, Volume: 280, Issue:1, 2005

Effect of inhibitors of myeloperoxidase on the development of aortic atherosclerosis in an animal model.
Experimental gerontology, , Volume: 40, Issue:3, 2005

Myeloperoxidase: friend and foe.
Journal of leukocyte biology, , Volume: 77, Issue:5, 2005

The year in atherothrombosis.
Journal of the American College of Cardiology, , Dec-07, Volume: 44, Issue:11, 2004

Human myeloperoxidase: a potential target for molecular MR imaging in atherosclerosis.
Magnetic resonance in medicine, , Volume: 52, Issue:5, 2004

Inflammatory and oxidative markers in atherosclerosis: relationship to outcome.
Current atherosclerosis reports, , Volume: 6, Issue:3, 2004

Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism.
The Journal of biological chemistry, , Feb-27, Volume: 279, Issue:9, 2004

Myeloperoxidase and plaque vulnerability.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 24, Issue:7, 2004

Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species.
The Journal of biological chemistry, , Oct-08, Volume: 279, Issue:41, 2004

Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease.
The Journal of clinical investigation, , Volume: 114, Issue:4, 2004

The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport.
Proceedings of the National Academy of Sciences of the United States of America, , Aug-31, Volume: 101, Issue:35, 2004

Monoclonal antibodies against LDL progressively oxidized by myeloperoxidase react with ApoB-100 protein moiety and human atherosclerotic lesions.
Biochemical and biophysical research communications, , Oct-29, Volume: 323, Issue:4, 2004

[Taurine is a possible anti-atherosclerotic agent].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 123, Issue:5, 2004

Interaction of myeloperoxidase with vascular NAD(P)H oxidase-derived reactive oxygen species in vasculature: implications for vascular diseases.
American journal of physiology. Heart and circulatory physiology, , Volume: 285, Issue:6, 2003

Myeloperoxidase-derived reactive chlorinating species from human monocytes target plasmalogens in low density lipoprotein.
The Journal of biological chemistry, , Sep-19, Volume: 278, Issue:38, 2003

Phagocytic activity and state of bactericidal systems in polymorphonuclear leukocytes from patients with Alzheimer's disease.
Bulletin of experimental biology and medicine, , Volume: 136, Issue:4, 2003

Effect of long-term hormone replacement therapy on atherosclerosis progression in postmenopausal women relates to myeloperoxidase promoter polymorphism.
The Journal of clinical endocrinology and metabolism, , Volume: 88, Issue:8, 2003

A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients.
Kidney international. Supplement, , Issue:84, 2003

Myeloperoxidase gene variation as a determinant of atherosclerosis progression in the abdominal and thoracic aorta: an autopsy study.
Laboratory investigation; a journal of technical methods and pathology, , Volume: 83, Issue:7, 2003

Tyrosyl radical production by myeloperoxidase: a phagocyte pathway for lipid peroxidation and dityrosine cross-linking of proteins.
Toxicology, , Aug-01, Volume: 177, Issue:1, 2002

Inflammatory bio-markers and cardiovascular risk prediction.
Journal of internal medicine, , Volume: 252, Issue:4, 2002

Polymorphic metabolizing genes and susceptibility to atherosclerosis among cigarette smokers.
Environmental and molecular mutagenesis, , Volume: 40, Issue:3, 2002

Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity.
Arteriosclerosis, thrombosis, and vascular biology, , Sep-01, Volume: 22, Issue:9, 2002

Pauci-immune extracapillary glomerulonephritis and atheromatous embolization.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 40, Issue:4, 2002

Oxidized amino acids: culprits in human atherosclerosis and indicators of oxidative stress.
Free radical biology & medicine, , Jun-01, Volume: 32, Issue:11, 2002

Oxidants and antioxidants in atherosclerosis.
Current opinion in lipidology, , Volume: 12, Issue:4, 2001

Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7). A mechanism for matrix metalloproteinase activation and atherosclerotic plaque rupture by myeloperoxidase.
The Journal of biological chemistry, , Nov-02, Volume: 276, Issue:44, 2001

Contributions of myeloperoxidase to proinflammatory events: more than an antimicrobial system.
International journal of hematology, , Volume: 74, Issue:2, 2001

The proper study of mankind.
The Journal of clinical investigation, , Volume: 107, Issue:4, 2001

Increased atherosclerosis in myeloperoxidase-deficient mice.
The Journal of clinical investigation, , Volume: 107, Issue:4, 2001

Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes.
The American journal of pathology, , Volume: 158, Issue:3, 2001

Hypochlorite-modified (lipo)proteins are present in rabbit lesions in response to dietary cholesterol.
Biochemical and biophysical research communications, , Dec-14, Volume: 289, Issue:4, 2001

Influence of non-enzymatically glycated collagen on monocyte-macrophage differentiation.
Atherosclerosis, , Volume: 159, Issue:2, 2001

Correlation between intima-to-media ratio, apolipoprotein B-100, myeloperoxidase, and hypochlorite-oxidized proteins in human atherosclerosis.
Free radical biology & medicine, , Nov-15, Volume: 31, Issue:10, 2001

Inflammatory markers in coronary artery disease: let prevention douse the flames.
JAMA, , Nov-07, Volume: 286, Issue:17, 2001

Association between myeloperoxidase levels and risk of coronary artery disease.
JAMA, , Nov-07, Volume: 286, Issue:17, 2001

Immunohistochemical evidence for the myeloperoxidase/H2O2/halide system in human atherosclerotic lesions: colocalization of myeloperoxidase and hypochlorite-modified proteins.
European journal of biochemistry, , Volume: 267, Issue:14, 2000

Elevated levels of protein-bound p-hydroxyphenylacetaldehyde, an amino-acid-derived aldehyde generated by myeloperoxidase, are present in human fatty streaks, intermediate lesions and advanced atherosclerotic lesions.
The Biochemical journal, , Dec-15, Volume: 352 Pt 3, 2000

Myeloperoxidase binds to low-density lipoprotein: potential implications for atherosclerosis.
FEBS letters, , Dec-29, Volume: 487, Issue:2, 2000

Oxidation of LDL by myeloperoxidase and reactive nitrogen species: reaction pathways and antioxidant protection.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 20, Issue:7, 2000

Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities.
Circulation, , May-30, Volume: 101, Issue:21, 2000

Myeloperoxidase-generated oxidants and atherosclerosis.
Free radical biology & medicine, , Jun-15, Volume: 28, Issue:12, 2000

Pathways of phospholipid oxidation by HOCl in human LDL detected by LC-MS.
Free radical biology & medicine, , Mar-01, Volume: 28, Issue:5, 2000

p-hydroxyphenylacetaldehyde, an aldehyde generated by myeloperoxidase, modifies phospholipid amino groups of low density lipoprotein in human atherosclerotic intima.
The Journal of biological chemistry, , Apr-07, Volume: 275, Issue:14, 2000

Comparison of HOCl traps with myeloperoxidase inhibitors in prevention of low density lipoprotein oxidation.
Biochimica et biophysica acta, , Aug-31, Volume: 1481, Issue:1, 2000

Possible existence of platelet activation before the onset of cerebral infarction.
Atherosclerosis, , Volume: 153, Issue:1, 2000

Modification of type III VLDL, their remnants, and VLDL from ApoE-knockout mice by p-hydroxyphenylacetaldehyde, a product of myeloperoxidase activity, causes marked cholesteryl ester accumulation in macrophages.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 19, Issue:5, 1999

Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro.
The Journal of clinical investigation, , Volume: 103, Issue:11, 1999

Oxidation of heparin-treated low density lipoprotein by peroxidases.
Atherosclerosis, , Volume: 146, Issue:2, 1999

Correlation of low-density lipoprotein modification by myeloperoxidase with hypochlorous acid formation.
International journal of clinical & laboratory research, , Volume: 29, Issue:4, 1999

Salicylate promotes myeloperoxidase-initiated LDL oxidation: antagonization by its metabolite gentisic acid.
Free radical biology & medicine, , Volume: 26, Issue:9-10, 1999

Mechanisms of oxidative damage by myeloperoxidase in atherosclerosis and other inflammatory disorders.
The Journal of laboratory and clinical medicine, , Volume: 133, Issue:4, 1999

Nitrogen dioxide radical generated by the myeloperoxidase-hydrogen peroxide-nitrite system promotes lipid peroxidation of low density lipoprotein.
FEBS letters, , Jul-23, Volume: 455, Issue:3, 1999

Modification of proteins and lipids by myeloperoxidase.
Methods in enzymology, , Volume: 300, 1999

Detecting oxidative modification of biomolecules with isotope dilution mass spectrometry: sensitive and quantitative assays for oxidized amino acids in proteins and tissues.
Methods in enzymology, , Volume: 300, 1999

Measurement of reactive oxygen species by chemiluminescence in diet-induced atherosclerosis: protective roles of vitamin E and probucol on different radical species.
International journal of clinical & laboratory research, , Volume: 28, Issue:2, 1998

Electron paramagnetic resonance detection of free tyrosyl radical generated by myeloperoxidase, lactoperoxidase, and horseradish peroxidase.
The Journal of biological chemistry, , Nov-27, Volume: 273, Issue:48, 1998

Human low density lipoprotein as a target of hypochlorite generated by myeloperoxidase.
Free radical biology & medicine, , Volume: 24, Issue:7-8, 1998

Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis.
Atherosclerosis, , Volume: 141, Issue:1, 1998

The molecular action of alpha-tocopherol in lipoprotein lipid peroxidation. Pro- and antioxidant activity of vitamin E in complex heterogeneous lipid emulsions.
Sub-cellular biochemistry, , Volume: 30, 1998

Long-term probucol treatment reverses the severity of myocardial injury in watanabe heritable hyperlipidemic rabbits.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 17, Issue:11, 1997

Mechanisms of oxidative damage of low density lipoprotein in human atherosclerosis.
Current opinion in lipidology, , Volume: 8, Issue:5, 1997

Mass spectrometric quantification of 3-chlorotyrosine in human tissues with attomole sensitivity: a sensitive and specific marker for myeloperoxidase-catalyzed chlorination at sites of inflammation.
Free radical biology & medicine, , Volume: 23, Issue:6, 1997

Pathways for oxidation of low density lipoprotein by myeloperoxidase: tyrosyl radical, reactive aldehydes, hypochlorous acid and molecular chlorine.
BioFactors (Oxford, England), , Volume: 6, Issue:2, 1997

Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical, copper, and hydroxyl radical in low density lipoprotein isolated from human atherosclerotic plaques.
The Journal of biological chemistry, , Feb-07, Volume: 272, Issue:6, 1997

3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.
The Journal of clinical investigation, , May-01, Volume: 99, Issue:9, 1997

Neutrophils obtained from obliterative atherosclerotic patients exhibit enhanced resting respiratory burst and increased degranulation in response to various stimuli.
Biochimica et biophysica acta, , Aug-23, Volume: 1316, Issue:3, 1996

Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.
The Journal of clinical investigation, , Volume: 94, Issue:1, 1994

Cellular mechanisms for the oxidative modification of lipoproteins: implications for atherogenesis.
Coronary artery disease, , Volume: 5, Issue:3, 1994

Ultrastructural localization of peroxidase in atherosclerotic lesions of pigeons.
Experimental and molecular pathology, , Volume: 57, Issue:3, 1992

[Myeloperoxidase of neutrophils and its possible role in lipid peroxidation processes in arteriosclerosis].
Klinicheskaia meditsina, , Volume: 67, Issue:6, 1989

Radical acetoacetate oxidation by myeloperoxidase, lactoperoxidase, prostaglandin synthetase, and prostacyclin synthetase: implications for atherosclerosis.
Biochemical medicine, , Volume: 29, Issue:2, 1983

[Myeloperoxidase activity in patients with complicated arteriosclerosis and in their relatives].
Klinicheskaia meditsina, , Volume: 59, Issue:3, 1981

Linking oxidative stress and inflammation in kidney disease: which is the chicken and which is the egg?
Seminars in dialysis, , Volume: 17, Issue:6

Inflammation and oxidative stress in ESRD--the role of myeloperoxidase.
Journal of nephrology, , Volume: 17 Suppl 8

Significance of the neutrophil myeloperoxidase index in patients with atherosclerotic diseases.
The Kobe journal of medical sciences, , Mar-13, Volume: 58, Issue:5, 2013

The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease.
Antioxidants & redox signaling, , 05-01, Volume: 32, Issue:13, 2020

Detecting Basal Myeloperoxidase Activity in Living Systems with a Near-Infrared Emissive "Turn-On" Probe.
Analytical chemistry, , 08-18, Volume: 92, Issue:16, 2020

Clinical Characteristics of Peripheral Neuropathy in Eosinophilic Granulomatosis with Polyangiitis: A Retrospective Single-Center Study in China.
Journal of immunology research, , Volume: 2020, 2020

Methyl jasmonate a stress phytohormone attenuates LPS induced in vivo and in vitro arthritis.
Molecular biology reports, , Volume: 46, Issue:1, 2019

Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K
Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 67, Issue:5, 2018

Two opposite extremes of adiposity similarly reduce inflammatory response of antigen-induced acute joint inflammation.
Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 33, 2017

Long-Term Effects of (-)-Epigallocatechin Gallate (EGCG) on Pristane-Induced Arthritis (PIA) in Female Dark Agouti Rats.
PloS one, , Volume: 11, Issue:3, 2016

Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats.
Neuroimmunomodulation, , Volume: 22, Issue:6, 2015

Temporomandibular joint arthritis as an initial presentation of acute myeloid leukemia with myelodysplasia-related changes: a report of an unusual case.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, , Volume: 72, Issue:9, 2014

6b,11b-Dihydroxy-6b,11b-dihydro-7H-indeno[1,2-b]naphtho[2,1-d]furan-7-one (DHFO), a small molecule targeting NF-κB, demonstrates therapeutic potential in immunopathogenic chronic inflammatory conditions.
International immunopharmacology, , Volume: 15, Issue:1, 2013

Treatment with Selemax®, a selenium-enriched yeast, ameliorates experimental arthritis in rats and mice.
The British journal of nutrition, , Nov-28, Volume: 108, Issue:10, 2012

Increased plasma myeloperoxidase levels in systemic lupus erythematosus.
Rheumatology international, , Volume: 30, Issue:6, 2010

Anti-inflammatory and antioxidant effects of Jeevaneeya Rasayana: an ayurvedic polyherbal formulation on acute and chronic models of inflammation.
Immunopharmacology and immunotoxicology, , Volume: 32, Issue:4, 2010

Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrugs of 5-aminosalicylic acid for colon-specific drug delivery in inflammatory bowel disease.
European journal of medicinal chemistry, , Volume: 44, Issue:10, 2009

Bioluminescence imaging of myeloperoxidase activity in vivo.
Nature medicine, , Volume: 15, Issue:4, 2009

Ibuprofen-arginine generates nitric oxide and has enhanced anti-inflammatory effects.
Pharmacological research, , Volume: 60, Issue:4, 2009

Measurement of equine myeloperoxidase (MPO) activity in synovial fluid by a modified MPO assay and evaluation of joint diseases - an initial case study.
Research in veterinary science, , Volume: 84, Issue:3, 2008

Restorative and synergistic efficacy of Kalpaamruthaa, a modified Siddha preparation, on an altered antioxidant status in adjuvant induced arthritic rat model.
Chemico-biological interactions, , Jul-20, Volume: 168, Issue:3, 2007

Arthritogenicity of collagen type II is increased by chlorination.
Clinical and experimental immunology, , Volume: 145, Issue:2, 2006

[Issues of side effects induced by antithyroid drugs].
Nihon rinsho. Japanese journal of clinical medicine, , Volume: 64, Issue:12, 2006

Jaccoud's nephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 20, Issue:3, 2005

An evaluation of the activity related to inflammation of four plants used in Thailand to treat arthritis.
Journal of ethnopharmacology, , Volume: 85, Issue:2-3, 2003

Expression of Fas ligand improves the effect of IL-4 in collagen-induced arthritis.
European journal of immunology, , Volume: 30, Issue:1, 2000

The type II decoy receptor of IL-1 inhibits murine collagen-induced arthritis.
European journal of immunology, , Volume: 30, Issue:3, 2000

Consequences of total and subtotal myeloperoxidase deficiency: risk or benefit ?
Acta haematologica, , Volume: 104, Issue:1, 2000

Confocal laser scanning microscopy of leukocyte adhesion in the microcirculation of the inflamed rat knee joint capsule.
Microcirculation (New York, N.Y. : 1994), , Volume: 6, Issue:2, 1999

Minocycline induced arthritis associated with fever, livedo reticularis, and pANCA.
Annals of the rheumatic diseases, , Volume: 55, Issue:10, 1996

Anti-CD8 treatment reduces the severity of inflammatory arthritis, but not vasculitis, in mercuric chloride-induced autoimmunity.
Clinical and experimental immunology, , Volume: 106, Issue:2, 1996

Goodpasture-like syndrome associated with anti-myeloperoxidase antibodies following penicillamine treatment.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 10, Issue:10, 1995

Antineutrophil cytoplasmic autoantibodies with myeloperoxidase specificity in a patient with anti-glomerular basement membrane disease.
The Netherlands journal of medicine, , Volume: 47, Issue:1, 1995

Metal content of neutrophil granules is altered in chronic inflammation.
Inflammation, , Volume: 13, Issue:4, 1989

[Leukocyte function in reactive arthritis].
Revmatologiia (Moscow, Russia), , Issue:3

A cross-sectional cohort study of the activity and turnover of neutrophil granulocytes in juvenile idiopathic arthritis.
Pediatric rheumatology online journal, , Jun-30, Volume: 19, Issue:1, 2021

Unstimulated salivary flow, pH, proteins and oral health in patients with Juvenile Idiopathic Arthritis.
BMC oral health, , Jun-02, Volume: 17, Issue:1, 2017

Increased carotid artery intima-media thickness and myeloperoxidase level in children with newly diagnosed juvenile idiopathic arthritis.
Arthritis research & therapy, , Jul-16, Volume: 17, 2015

Salivary gland involvement and oxidative stress in juvenile idiopathic arthritis: novel observation in oligoarticular-type patients.
The Journal of rheumatology, , Volume: 33, Issue:12, 2006

Nitric oxide-derived species in synovial fluid from patients with juvenile idiopathic arthritis.
The Journal of rheumatology, , Volume: 31, Issue:5, 2004

[A case of juvenile rheumatoid arthritis with MPO-ANCA associated nephritis].
Ryumachi. [Rheumatism], , Volume: 38, Issue:1, 1998

Crescentic glomerulonephritis in juvenile chronic arthritis.
The Journal of rheumatology, , Volume: 23, Issue:9, 1996

[Clinical evaluation of changes in the functional and cytochemical activity of the neutrophils in children with rheumatoid arthritis].
Voprosy okhrany materinstva i detstva, , Volume: 24, Issue:10, 1979

Effects of infliximab on cytokines, myeloperoxidase, and soluble adhesion molecules in patients with juvenile idiopathic arthritis.
Scandinavian journal of rheumatology, , Volume: 36, Issue:3

Occurrence of autoantibodies against neutrophil granulocyte components in juvenile chronic arthritis.
Clinical and experimental rheumatology, , Volume: 9, Issue:1

Prevalence of anti-neutrophil cytoplasmic antibodies (ANCA) in juvenile chronic arthritis.
Clinical and experimental rheumatology, , Volume: 14, Issue:2

Endocrine autoimmunity in young patients with juvenile chronic arthritis.
Clinical and experimental rheumatology, , Volume: 20, Issue:4

Pancreatic ascites hemoglobin contributes to the systemic response in acute pancreatitis.
Free radical biology & medicine, , Volume: 81, 2015

Heme oxygenase 1-generated carbon monoxide and biliverdin attenuate the course of experimental necrotizing pancreatitis.
Pancreas, , Volume: 42, Issue:2, 2013

CO2 abdominal insufflation decreases local and systemic inflammatory response in experimental acute pancreatitis.
Pancreas, , Volume: 39, Issue:2, 2010

Mechanisms of the beneficial effect of hypertonic saline solution in acute pancreatitis.
Shock (Augusta, Ga.), , Volume: 34, Issue:5, 2010

Tumor growth, angiogenesis and inflammation in mice lacking receptors for platelet activating factor (PAF).
Life sciences, , Jun-27, Volume: 81, Issue:3, 2007

Flow cytometric analysis of effusions in dogs and cats with the automated haematology analyser ADVIA 120.
The Veterinary record, , May-21, Volume: 156, Issue:21, 2005

Effect of simultaneous inhibition of TNF-alpha production and xanthine oxidase in experimental acute pancreatitis: the role of mitogen activated protein kinases.
Annals of surgery, , Volume: 240, Issue:1, 2004

Do peritoneal macrophages play an essential role in the progression of acute pancreatitis in rats?
Pancreas, , Volume: 27, Issue:3, 2003

Mast cells may not play a crucial role in the pathogenesis of experimental closed duodenal loop-induced pancreatitis in rats.
Pancreas, , Volume: 24, Issue:3, 2002

"Isolated" peritoneal granulocytic sarcoma with molecular and chromosomal bone marrow involvement.
Haematologica, , Volume: 87, Issue:1, 2002

Reduced neutrophil sequestration in lung tissue after laparoscopic lavage in a rat peritonitis model.
World journal of surgery, , Volume: 26, Issue:1, 2002

Ascites of rat experimental model of severe acute pancreatitis induces lung injury.
Pancreas, , Volume: 22, Issue:4, 2001

Quality control of coated antibodies: new, rapid determination of binding affinity.
Clinical chemistry and laboratory medicine, , Volume: 38, Issue:3, 2000

Fasting exacerbates acute pancreatitis by occlusion of the common bile duct in rats.
Japanese journal of pharmacology, , Volume: 84, Issue:4, 2000

Role of interleukin-6 in a non-septic shock model induced by zymosan.
European cytokine network, , Volume: 10, Issue:2, 1999

Ascorbate deficiency impairs the muscarinic-cholinergic and ss-adrenergic receptor signaling systems in the guinea pig submandibular salivary gland.
The Journal of nutrition, , Volume: 130, Issue:12, 2000

Phagocytosis and leukocyte enzymes in ascorbic acid deficient guinea pigs.
The Journal of nutrition, , Volume: 107, Issue:8, 1977

Role of particulate antigens of Aspergillus in murine eosinophilia.
International archives of allergy and immunology, , Volume: 112, Issue:3, 1997

Immunopathologic responses to Aspergillus antigen in interleukin-4 knockout mice.
The Journal of laboratory and clinical medicine, , Volume: 130, Issue:6, 1997

Lung injury after asphyxia and hemorrhagic shock in newborn piglets: Analysis of structural and inflammatory changes.
PloS one, , Volume: 14, Issue:7, 2019

Protective effects of NHE1 inhibition with sabiporide in an experimental model of asphyxia-induced cardiac arrest in piglets.
Resuscitation, , Volume: 84, Issue:4, 2013

Chronic pulmonary bleeding as the first sign of microscopic polyangiitis associated with autoimmune thyroiditis.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, , Volume: 31, Issue:4, 2011

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Inflammation markers and symptom activity in children with bronchial asthma. Influence of atopy and eczema.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, , Volume: 8, Issue:3, 1997

Genetic immunodeficiencies: cutaneous manifestations and recent progress.
Journal of the American Academy of Dermatology, , Volume: 33, Issue:1, 1995

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Inflammation and thrombo-occlusive vessel signalling in benign atrophic papulosis (Köhlmeier-Degos disease).
Journal of the European Academy of Dermatology and Venereology : JEADV, , Volume: 36, Issue:11, 2022

Implication of platelets and complement C3 as link between innate immunity and tubulointerstitial injury in renal vasculitis with MPO-ANCA seropositivity.
Frontiers in immunology, , Volume: 13, 2022

Histochemical characteristics of regressing vessels in the hyaloid vascular system of neonatal mice: Novel implication for vascular atrophy.
Experimental eye research, , Volume: 172, 2018

Recurrent lipoatrophic panniculitis of children.
Journal of the European Academy of Dermatology and Venereology : JEADV, , Volume: 31, Issue:3, 2017

Myenteric plexuses atrophy in the vicinity of colorectal cancer tissue is not caused by apoptosis or necrosis.
Folia histochemica et cytobiologica, , Volume: 54, Issue:2, 2016

Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats.
World journal of gastroenterology, , Mar-14, Volume: 20, Issue:10, 2014

Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats.
Journal of molecular medicine (Berlin, Germany), , Volume: 85, Issue:5, 2007

Intraoral duct ligation without inclusion of the parasympathetic nerve supply induces rat submandibular gland atrophy.
International journal of experimental pathology, , Volume: 87, Issue:1, 2006

SLE and rapidly progressive glomerulonephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 45, Issue:5, 2005

Association of apolipoprotein E and myeloperoxidase genotypes to clinical course of familial and sporadic multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England), , Volume: 10, Issue:3, 2004

Elevated blood levels of inflammation-related proteins are associated with an attention problem at age 24 mo in extremely preterm infants.
Pediatric research, , Volume: 75, Issue:6, 2014

Metal-organic framework-modulated Fe
Journal of nanobiotechnology, , Nov-15, Volume: 21, Issue:1, 2023

Cu-GA-coordination polymer nanozymes with triple enzymatic activity for wound disinfection and accelerated wound healing.
Acta biomaterialia, , 09-01, Volume: 167, 2023

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Iron Phosphate Nanozyme-Hydrogel with Multienzyme-like Activity for Efficient Bacterial Sterilization.
ACS applied materials & interfaces, , Apr-27, Volume: 14, Issue:16, 2022

Metal-Organic Framework Modified MoS
Advanced healthcare materials, , Volume: 11, Issue:1, 2022

Glutathione-depletion reinforced enzyme catalytic activity for photothermal assisted bacterial killing by hollow mesoporous CuO.
Journal of materials chemistry. B, , 11-09, Volume: 10, Issue:43, 2022

An intrinsically thermogenic nanozyme for synergistic antibacterial therapy.
Biomaterials science, , Dec-07, Volume: 9, Issue:24, 2021

COVID-19 associated Kikuchi-Fujimoto disease.
British journal of haematology, , Volume: 192, Issue:5, 2021

Diagnosis of bacterial urinary tract infection: Utility of urine myeloperoxidase concentration to predict urine culture results in dogs.
PloS one, , Volume: 15, Issue:5, 2020

Neutrophil Elastase Activity as a Surrogate Marker for Neutrophil Extracellular Trap Formation following Hematopoietic Stem Cell Transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, , Volume: 25, Issue:12, 2019

A H
Nanoscale, , Sep-27, Volume: 10, Issue:37, 2018

Associations of periparturient plasma biochemical parameters, endometrial leukocyte esterase and myeloperoxidase, and bacterial detection with clinical and subclinical endometritis in postpartum dairy cows.
The Journal of veterinary medical science, , Feb-20, Volume: 80, Issue:2, 2018

Unraveling the Enzymatic Activity of Oxygenated Carbon Nanotubes and Their Application in the Treatment of Bacterial Infections.
Nano letters, , 06-13, Volume: 18, Issue:6, 2018

Methods for In Vivo/Ex Vivo Analysis of Antimicrobial Peptides in Bacterial Keratitis: siRNA Knockdown, Colony Counts, Myeloperoxidase, Immunostaining, and RT-PCR Assays.
Methods in molecular biology (Clifton, N.J.), , Volume: 1548, 2017

Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology.
PloS one, , Volume: 11, Issue:1, 2016

Serum levels of the soluble haemoglobin scavenger receptor CD163 in MPO-ANCA-associated renal vasculitis.
Scandinavian journal of rheumatology, , Volume: 45, Issue:5, 2016

Equine myeloperoxidase: a novel biomarker in synovial fluid for the diagnosis of infection.
Equine veterinary journal, , Volume: 45, Issue:3, 2013

Laccase-assisted formation of bioactive chitosan/gelatin hydrogel stabilized with plant polyphenols.
Carbohydrate polymers, , Feb-15, Volume: 92, Issue:2, 2013

Serum procalcitonin levels in patients with myeloperoxidase-antineutrophil cytoplasmic antibodies-associated glomerulonephritis.
The American journal of the medical sciences, , Volume: 343, Issue:2, 2012

Liver injury and abscess formation in secondary murine peritonitis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 60, Issue:4, 2011

Serum ratio of soluble triggering receptor expressed on myeloid cells-1 to creatinine is a useful marker of infectious complications in myeloperoxidase-antineutrophil cytoplasmic antibody-associated renal vasculitis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 26, Issue:3, 2011

Clinical and immunological features of drug-induced and infection-induced proteinase 3-antineutrophil cytoplasmic antibodies and myeloperoxidase-antineutrophil cytoplasmic antibodies and vasculitis.
Current opinion in rheumatology, , Volume: 22, Issue:1, 2010

Association between the neutrophil myeloperoxidase index and subsets of bacterial infections.
International journal of laboratory hematology, , Volume: 32, Issue:6 Pt 2, 2010

Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injury.
Surgery, , Volume: 148, Issue:3, 2010

Biology of the eosinophil.
Advances in immunology, , Volume: 101, 2009

Utility of reflexive semen cultures for detecting bacterial infections in patients with infertility and leukocytospermia.
Fertility and sterility, , Volume: 91, Issue:4 Suppl, 2009

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.
Antioxidants & redox signaling, , Volume: 10, Issue:2, 2008

[Immunotropic effects of probiotic complex bactistatin used simultaneously with antibiotics].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], , Volume: 53, Issue:1-2, 2008

Use of pharmacodynamic endpoints for the evaluation of levofloxacin for the treatment of acute maxillary sinusitis.
Diagnostic microbiology and infectious disease, , Volume: 61, Issue:1, 2008

Study of the efficacy of Coated VICRYL Plus Antibacterial suture (coated Polyglactin 910 suture with Triclosan) in two animal models of general surgery.
The Journal of infection, , Volume: 54, Issue:1, 2007

Immunobiological changes of in vivo glucocorticoid depleted male Swiss albino rats.
Immunobiology, , Volume: 212, Issue:1, 2007

Intraabdominal bacterial infections significantly alter regeneration and function of the liver in a rat model of major hepatectomy.
Langenbeck's archives of surgery, , Volume: 392, Issue:3, 2007

Organ specific apoptosis following polymicrobial intraperitoneal infection.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 55, Issue:4, 2006

Mean peroxidase index as a potential marker for neonatal infection.
The Pediatric infectious disease journal, , Volume: 25, Issue:12, 2006

[Production of active oxygen by neutrophils in patients with cancer of the esophagus and stomach before and after surgical interventions].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], , Volume: 50, Issue:4, 2005

Leukotriene B4 receptor (BLT-1) modulates neutrophil influx into the peritoneum but not the lung and liver during surgically induced bacterial peritonitis in mice.
Clinical and diagnostic laboratory immunology, , Volume: 11, Issue:5, 2004

Reevaluating gel-forming mucins' roles in cystic fibrosis lung disease.
Free radical biology & medicine, , Nov-15, Volume: 37, Issue:10, 2004

Genetic background determines susceptibility during murine septic peritonitis.
The Journal of surgical research, , Volume: 102, Issue:1, 2002

Endothelial E- and P-selectin expression in iNOS- deficient mice exposed to polymicrobial sepsis.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 280, Issue:2, 2001

Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine, , Volume: 163, Issue:2, 2001

Soluble adhesion molecules, cytokines and cellular markers in serum in patients with acute infections.
Scandinavian journal of infectious diseases, , Volume: 33, Issue:4, 2001

Differential host susceptibility to pulmonary infections with bacteria and fungi in mice deficient in myeloperoxidase.
The Journal of infectious diseases, , Volume: 182, Issue:4, 2000

Bronchial inflammation: its relationship to colonizing microbial load and alpha(1)-antitrypsin deficiency.
Chest, , Volume: 117, Issue:5 Suppl 1, 2000

Immunopathology of a two-hit murine model of acid aspiration lung injury.
American journal of physiology. Lung cellular and molecular physiology, , Volume: 278, Issue:3, 2000

Therapeutic efficacy of continuous arterial infusion of an antibiotic and a protease inhibitor via the superior mesenteric artery for acute pancreatitis in an animal model.
Pancreas, , Volume: 21, Issue:3, 2000

The effects of two antiinflammatory pretreatments on bacterial-induced lung injury.
Anesthesiology, , Volume: 90, Issue:6, 1999

Proteinase 3 mRNA expression is induced in monocytes but not in neutrophils of patients with cystic fibrosis.
FEBS letters, , Sep-03, Volume: 457, Issue:3, 1999

Temporal sequence of pulmonary and systemic inflammatory responses to graded polymicrobial peritonitis in mice.
Infection and immunity, , Volume: 67, Issue:11, 1999

Evidence for excessive bronchial inflammation during an acute exacerbation of chronic obstructive pulmonary disease in patients with alpha(1)-antitrypsin deficiency (PiZ).
American journal of respiratory and critical care medicine, , Volume: 160, Issue:6, 1999

CNI-1493 attenuates hemodynamic and pro-inflammatory responses to LPS.
Shock (Augusta, Ga.), , Volume: 10, Issue:5, 1998

Myeloperoxidase in urine: a new marker for distinction between rejection and urinary tract infection after renal transplantation.
Transplantation proceedings, , Volume: 29, Issue:7, 1997

Role of oxidants in microbial pathophysiology.
Clinical microbiology reviews, , Volume: 10, Issue:1, 1997

Incrimination of anaerobic bacteria in the induction of experimental colitis.
The American journal of physiology, , Volume: 272, Issue:1 Pt 1, 1997

Differential excretion of leucocyte granule components in inflammatory bowel disease: implications for pathogenesis.
Clinical science (London, England : 1979), , Volume: 92, Issue:3, 1997

The differential release of eosinophil granule proteins. Studies on patients with acute bacterial and viral infections.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 25, Issue:8, 1995

Disorders of neutrophil function.
Blood reviews, , Volume: 9, Issue:3, 1995

Serum levels of granulocyte-colony stimulating factor (G-CSF) in bacterial and viral infections, and in atypical pneumonia.
British journal of haematology, , Volume: 88, Issue:2, 1994

Impaired neutrophil bactericidal activity correlates with the infection occurring after surgery for esophageal cancer.
Journal of surgical oncology, , Volume: 51, Issue:3, 1992

[Prognostic value of the leukogram and the myeloperoxidase activity of neutrophilic granulocytes in infectious complications in children with severe burns].
Klinicheskaia khirurgiia, , Issue:3, 1992

Detection of anti-myeloperoxidase and anti-elastase antibodies in vasculitides and infections.
Clinical and experimental immunology, , Volume: 84, Issue:2, 1991

Fast double antibody radioimmunoassay of human granulocyte myeloperoxidase and its application to plasma.
Journal of immunological methods, , Mar-21, Volume: 137, Issue:2, 1991

Role of neutrophils in the intestinal alterations associated with thermal injury.
Burns : journal of the International Society for Burn Injuries, , Volume: 16, Issue:5, 1990

Studies on phagocytosis in patients with acute bacterial infections.
The Journal of clinical investigation, , Volume: 83, Issue:1, 1989

[Myeloperoxidase deficiency of the peripheral blood neutrophils and the incidence of infectious complications in patients with acute myeloblastic leukemia].
Vrachebnoe delo, , Issue:3, 1989

[Insufficiency of intra-abdominal immunity to infection in purulent peritonitis--sequela of disordered foreign body opsonization].
Klinische Wochenschrift, , Mar-15, Volume: 67, Issue:6, 1989

Acquired myeloperoxidase deficiency of neutrophils in a patient with aplastic anemia (idiopathic marrow aplasia).
Acta haematologica, , Volume: 80, Issue:2, 1988

Chemiluminescence response of polymorphonuclear leucocytes to serum-opsonized zymosan--a predictive parameter for infections and prognosis in multiple myeloma patients.
Clinical and laboratory haematology, , Volume: 10, Issue:4, 1988

[Myeloperoxidase activity of neutrophils and the frequency of emergence of infectious complications in myeloproliferative disorders].
Arkhiv patologii, , Volume: 50, Issue:1, 1988

Granulocyte chemiluminescence in patients with postoperative infections.
Archives of surgery (Chicago, Ill. : 1960), , Volume: 123, Issue:1, 1988

[Clinical significance of the bactericidal systems in endogenous infections].
Klinicheskaia meditsina, , Volume: 64, Issue:4, 1986

NBT dye reduction test & myeloperoxidase activity of neutrophils in pregnant & non-pregnant women.
The Indian journal of medical research, , Volume: 81, 1985

Automated cytochemical differential leucocyte count in patients hospitalized with acute bacterial infections.
Scandinavian journal of infectious diseases, , Volume: 17, Issue:2, 1985

Myelolactoferrin index (MLF) and myelopoiesis during bacterial infections and malignant diseases.
Haematology and blood transfusion, , Volume: 29, 1985

Neutrophil myeloperoxidase concentration: changes with development and during bacterial infection.
Pediatric research, , Volume: 19, Issue:12, 1985

Myeloperoxidase-deficient polymorphonuclear leucocytes (III): Relation to incidence of infection in acute myeloid leukaemia.
Scandinavian journal of haematology, , Volume: 33, Issue:1, 1984

[Myeloperoxidase deficiency in polymorphonuclear cells of children with recurrent infections].
Boletin medico del Hospital Infantil de Mexico, , Volume: 41, Issue:11, 1984

Serum-levels of lactoferrin, lysozyme and myeloperoxidase in normal, infection-prone and leukemic children.
Clinica chimica acta; international journal of clinical chemistry, , Jan-31, Volume: 136, Issue:2-3, 1984

Defective bactericidal activity and absence of specific granules in neutrophils from a patient with recurrent bacterial infections.
Journal of clinical immunology, , Volume: 4, Issue:1, 1984

Effect of two antibiotics on human granulocyte activities.
The Journal of antimicrobial chemotherapy, , Volume: 11, Issue:6, 1983

Association of neutrophil chemiluminescence with microbicidal activity.
Clinical immunology and immunopathology, , Volume: 22, Issue:2, 1982

Susceptibility of Legionella pneumophila to oxygen-dependent microbicidal systems.
Journal of immunology (Baltimore, Md. : 1950), , Volume: 129, Issue:5, 1982

[Role of neutrophilic leukocytes in the immune response to infection].
Revista clinica espanola, , Dec-31, Volume: 167, Issue:6, 1982

[Iron and infection].
Padiatrie und Grenzgebiete, , Volume: 20, Issue:1-2, 1981

[Lysosomal-cation test and the prospects of its use in pathomorphological and laboratory diagnostic practice].
Arkhiv patologii, , Volume: 41, Issue:5, 1979

Oxygen-dependent microbial killing by phagocytes (second of two parts).
The New England journal of medicine, , Mar-30, Volume: 298, Issue:13, 1978

Neutrophil and eosinophil granulocytes in bacterial infection: sequential studies of cellular and serum levels of granule proteins.
British journal of haematology, , Volume: 38, Issue:4, 1978

Bactericidal activity of human neutrophil granulocytes. Studies in clinical disorders with the in vitro bactericidal test.
Acta pathologica et microbiologica Scandinavica. Supplement, , Issue:266, 1978

Iron and immunocompetence.
Nutrition reviews, , Volume: 34, Issue:5, 1976

Neutrophilic granulocytes in acute bacterial infection. Sequential studies on lysozyme, myeloperoxidase and lactoferrin.
Clinical and experimental immunology, , Volume: 26, Issue:3, 1976

Particle-induced myeloperoxidase release in serially diluted whole blood quantifies the number and the phagocytic activity of blood neutrophils and opsonization capacity of plasma.
Luminescence : the journal of biological and chemical luminescence, , Volume: 21, Issue:3

Lipoprotein-associated phospholipase A2, myeloperoxidase and vascular endothelial growth factor - predictors of high vascular risk in respiratory bacterial infections.
Journal of medicine and life, , Volume: 9, Issue:4

[Study of the functional capacity of the neutrophil granulocyte by means of the NBT reduction test].
Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna, , Volume: 30, Issue:3

Evaluation of a 4-protein serum biomarker panel-biglycan, annexin-A6, myeloperoxidase, and protein S100-A9 (B-AMP)-for the detection of esophageal adenocarcinoma.
Cancer, , Dec-15, Volume: 120, Issue:24, 2014

Long-term results of ablation with antireflux surgery for Barrett's esophagus: a clinical and molecular biologic study.
Surgical endoscopy, , Volume: 26, Issue:7, 2012

Effect of inflammation on cyclooxygenase (COX)-2 expression in benign and malignant oesophageal cells.
Carcinogenesis, , Volume: 26, Issue:9, 2005

Simultaneous progression of oxidative stress and angiogenesis in malignant transformation of Barrett esophagus.
The Journal of thoracic and cardiovascular surgery, , Volume: 126, Issue:6, 2003

Oxidative stress has a role in malignant transformation in Barrett's oesophagus.
International journal of cancer, , Dec-20, Volume: 102, Issue:6, 2002

Mucosal reactive oxygen species production in oesophagitis and Barrett's oesophagus.
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[Case of microscopic polyangiitis accompanied by central nervous system symptoms and brain vasculitis observed histopathologically].
Nihon Jinzo Gakkai shi, , Volume: 53, Issue:4, 2011

IL-8 Triggers Neutrophil Extracellular Trap Formation Through an Nicotinamide Adenine Dinucleotide Phosphate Oxidase- and Mitogen-Activated Protein Kinase Pathway-Dependent Mechanism in Uveitis.
Investigative ophthalmology & visual science, , 10-03, Volume: 64, Issue:13, 2023

Oxidases and oxygenases in regulation of neutrophil redox pathways in Behçet's disease patients.
Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:1, 2012

Lack of association of the -463 G/A myeloperoxidase promoter polymorphism with Behcet's disease in Italian patients.
Rheumatology (Oxford, England), , Volume: 46, Issue:10, 2007

Increased advanced oxidation protein products in Behçet's disease: a new activity marker?
The British journal of dermatology, , Volume: 151, Issue:1, 2004

Enhancement of endothelial cell E-selectin expression by sera from patients with active Behçet's disease: moderate correlation with anti-endothelial cell antibodies and serum myeloperoxidase levels.
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A case of renal granulomatosis with polyangiitis following intravesical bacillus Calmette-Guérin therapy.
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Process to evaluate hematological parameters that reflex to manual differential cell counts in a pediatric institution.
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Acute myeloid leukemia associated with t(10;17)(p13-15;q12-21) and phagocytic activity by leukemic blasts: a clinical study and review of the literature.
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An updated approach to the diagnosis of myeloid leukemia cutis.
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The percentage of myeloperoxidase-positive blast cells is a strong independent prognostic factor in acute myeloid leukemia, even in the patients with normal karyotype.
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Expression of NK-associated antigens in extramedullary lymph nodal blast crisis of chronic myeloid leukemia on fine-needle cytology.
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Acute myeloid leukemia with hypergranular cytoplasm: a differential diagnosis of acute promyelocytic leukemia.
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Blast crisis of chronic myelogenous leukemia exhibiting immunophenotypic features of a myeloid/natural killer cell precursor.
International journal of hematology, , Volume: 69, Issue:2, 1999

Myeloperoxidase mRNA analysis in acute lymphoblastic leukemia.
Diagnostic molecular pathology : the American journal of surgical pathology, part B, , Volume: 6, Issue:3, 1997

The value of the ultrastructural pattern of myeloperoxidase and platelet peroxidase in identification of two blastic cell types during transformation of a chronic myeloproliferative disorder.
Haematologia, , Volume: 27, Issue:3, 1996

Myeloperoxidase mRNA analysis in acute lymphoblastic leukemia.
Diagnostic molecular pathology : the American journal of surgical pathology, part B, , Volume: 5, Issue:4, 1996

Immunophenotype and ultrastructural studies in blast crisis of chronic myeloid leukemia.
Leukemia & lymphoma, , Volume: 19, Issue:3-4, 1995

Use of polyclonal anti-myeloperoxidase antibody in myeloid lineage determination.
The Indian journal of medical research, , Volume: 100, 1994

Establishment of a new cell line with the characteristics of a multipotential progenitor from a patient with chronic myelogenous leukemia in early erythroblastic crisis.
Leukemia, , Volume: 8, Issue:1, 1994

Monoclonal antibody anti-MPO is useful in recognizing minimally differentiated acute myeloid leukaemia.
Leukemia & lymphoma, , Volume: 12, Issue:3-4, 1994

Detection of leukemic blasts in peripheral blood specimens by reverse transcriptase polymerase chain reaction assay for myeloperoxidase mRNA.
Diagnostic molecular pathology : the American journal of surgical pathology, part B, , Volume: 2, Issue:4, 1993

Ultrastructural and ultracytochemical differences between megakaryoblastic leukemia in children and adults. Analysis of 49 patients.
Cancer, , Jul-15, Volume: 70, Issue:2, 1992

Differentiation induction of blast cells in two cases of childhood acute megakaryoblastic leukemia in vitro by interleukin-3 and interleukin-6: an ultrastructural cytochemical study.
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Expression of the myeloperoxidase gene in acute and chronic myeloid leukemias: relationship to the expression of cell cycle-related genes.
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Bilineage T-lymphoblastic/myeloid extramedullary blast crisis in chronic myelogenous leukemia.
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Acute inflammation of the eyelid and cornea in Staphylococcus keratitis in the rabbit.
Investigative ophthalmology & visual science, , Volume: 40, Issue:2, 1999

Adjunctive treatment of murine neuroblastoma with 6-hydroxydopamine and Tempol.
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MPO-ANCA Vasculitis Pachymeningitis with Bilateral Vision Loss.
Minnesota medicine, , Volume: 98, Issue:8, 2015

Relationship between the development of blindness in Churg-Strauss syndrome and anti-myeloperoxidase antibodies.
British journal of rheumatology, , Volume: 36, Issue:2, 1997

Thrombomodulin improved liver injury, coagulopathy, and mortality in an experimental heatstroke model in mice.
Anesthesia and analgesia, , Volume: 118, Issue:5, 2014

Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation.
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Neutrophils in the gray platelet syndrome.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
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Mocetinostat activates Krüppel-like factor 4 and protects against tissue destruction and inflammation in osteoarthritis.
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[no title available]
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Peroxidase-Like Platinum Clusters Synthesized by
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Competitive method for fluorescent dopamine detection in cerebrospinal fluid based on the peroxidase-like activity of ficin.
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The protective effect of polymerized porcine hemoglobin (pPolyHb) on transient focal cerebral ischemia/reperfusion injury.
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Delayed encephalopathy of acute carbon monoxide intoxication in rats: potential mechanism and intervention of dexamethasone.
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A patient with steroid responsive encephalopathy associated with autoimmune thyroiditis.
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[Case of microscopic polyangiitis accompanied by central nervous system symptoms and brain vasculitis observed histopathologically].
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Silymarin, the antioxidant component of Silybum marianum, prevents sepsis-induced acute lung and brain injury.
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THREE UNEXPECTED PRODUCTS OF PEROXIDASE REACTION; BRAIN SITE OF LESION, BERIBERI POISON AND NEW DISEASE.
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Molecular Imaging Unravels Cerebral Malaria.
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MRI of Iron Oxide Nanoparticles and Myeloperoxidase Activity Links Inflammation to Brain Edema in Experimental Cerebral Malaria.
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Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum.
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Effects of Sulphasalazine in Cerebral Ischemia Reperfusion Injury in Rat.
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Elevated Leukocyte Azurophilic Enzymes in Human Diabetic Ketoacidosis Plasma Degrade Cerebrovascular Endothelial Junctional Proteins.
Critical care medicine, , Volume: 44, Issue:9, 2016

The effect of amifostine on pathophysiological changes in vasogenic brain edema induced by an experimental cold injury model.
Turkish neurosurgery, , Volume: 25, Issue:1, 2015

Protective effects of allicin against ischemic stroke in a rat model of middle cerebral artery occlusion.
Molecular medicine reports, , Volume: 12, Issue:3, 2015

Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury.
Journal of neuroinflammation, , Sep-04, Volume: 12, 2015

The Effect of Pre-Condition Cerebella Fastigial Nucleus Electrical Stimulation within and beyond the Time Window of Thrombolytic on Ischemic Stroke in the Rats.
PloS one, , Volume: 10, Issue:5, 2015

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite.
Journal of neuroinflammation, , Oct-17, Volume: 12, 2015

PPAR-γ activator induces neuroprotection in hypercholesterolemic rats subjected to global cerebral ischemia/reperfusion injury: in vivo and in vitro inhibition of oxidative stress.
Experimental gerontology, , Volume: 51, 2014

Cannabinoid type 2 receptor stimulation attenuates brain edema by reducing cerebral leukocyte infiltration following subarachnoid hemorrhage in rats.
Journal of the neurological sciences, , Jul-15, Volume: 342, Issue:1-2, 2014

Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia.
Journal of neurochemistry, , Volume: 129, Issue:5, 2014

Lithium pretreatment reduces brain injury after intracerebral hemorrhage in rats.
Neurological research, , Volume: 34, Issue:5, 2012

Tropisetron ameliorates ischemic brain injury in an embolic model of stroke.
Brain research, , May-25, Volume: 1392, 2011

Alpha lipoic acid alleviates oxidative stress and preserves blood brain permeability in rats with subarachnoid hemorrhage.
Neurochemical research, , Volume: 35, Issue:3, 2010

The protective effect of alpha lipoic acid against traumatic brain injury in rats.
Free radical research, , Volume: 43, Issue:7, 2009

Effects of combination treatment of dexamethasone and melatonin on brain injury in intracerebral hemorrhage model in rats.
Brain research, , Apr-06, Volume: 1264, 2009

Anti-oxidant activity mediated neuroprotective potential of trimetazidine on focal cerebral ischaemia-reperfusion injury in rats.
Clinical and experimental pharmacology & physiology, , Volume: 35, Issue:5-6, 2008

Matrix metalloproteinase inhibition attenuates brain edema after surgical brain injury.
Acta neurochirurgica. Supplement, , Volume: 102, 2008

Neuroprotective effect of erythropoietin after experimental cold injury-induced vasogenic brain edema in rats.
Surgical neurology, , Volume: 70, Issue:5, 2008

Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents.
Brain research, , Jun-18, Volume: 1215, 2008

Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat.
Behavioural brain research, , Nov-21, Volume: 193, Issue:2, 2008

Reduced brain injury in CD18-deficient mice after experimental intracerebral hemorrhage.
Journal of neuroscience research, , Nov-01, Volume: 86, Issue:14, 2008

The pre-treatment effect on brain injury during restoration of normal perfusion pressure with hemodilution in a new rat model of chronic cerebral hypoperfusion.
Neurological research, , Volume: 29, Issue:6, 2007

Inhibition of tyrosine kinase-mediated cellular signalling by Tyrphostins AG126 and AG556 modulates secondary damage in experimental spinal cord trauma.
Neuropharmacology, , Volume: 52, Issue:7, 2007

Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 27, Issue:7, 2007

Attenuation of brain inflammatory response after focal cerebral ischemia/reperfusion with Xuesaitong injection in rats.
Chinese journal of integrative medicine, , Volume: 12, Issue:3, 2006

Overexpression of interleukin-1 receptor antagonist reduces brain edema induced by intracerebral hemorrhage and thrombin.
Acta neurochirurgica. Supplement, , Volume: 86, 2003

Neuroprotective effects of (S)-N-[4-[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)carbonyl]-1-piperazinyl]phenyl]-2-thiophenecarboximid-amide (BN 80933), an inhibitor of neuronal nitric-oxide synthase and an antioxidant, in model of
The Journal of pharmacology and experimental therapeutics, , Volume: 306, Issue:2, 2003

Effect of hypothermia on brain edema formation following intracerebral hemorrhage in rats.
Acta neurochirurgica. Supplement, , Volume: 86, 2003

Mild hypothermia induced before cardiac arrest reduces brain edema formation in rats.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, , Volume: 9, Issue:2, 2002

Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist.
Journal of neurosurgery, , Volume: 95, Issue:4, 2001

Systemic complement depletion diminishes perihematomal brain edema in rats.
Stroke, , Volume: 32, Issue:1, 2001

Protective effect of endothelin type A receptor antagonist on brain edema and injury after transient middle cerebral artery occlusion in rats.
Stroke, , Volume: 32, Issue:9, 2001

Effects of hypothermia on thrombin-induced brain edema formation.
Brain research, , Mar-23, Volume: 895, Issue:1-2, 2001

Protective effects of melatonin in ischemic brain injury.
Journal of pineal research, , Volume: 29, Issue:4, 2000

Beneficial effects of n-acetylcysteine on ischaemic brain injury.
British journal of pharmacology, , Volume: 130, Issue:6, 2000

Effects of tempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury.
Brain research, , Sep-01, Volume: 875, Issue:1-2, 2000

Changes of MPO activity and brain water accumulation in traumatic brain injury experiments.
Acta neurochirurgica. Supplement, , Volume: 70, 1997

New therapeutic possibility of blocking cytokine-induced neutrophil chemoattractant on transient ischemic brain damage in rats.
Brain research, , Jun-06, Volume: 759, Issue:1, 1997

Multiple actions of the coumarine derivative cloricromene and its protective effects on ischemic brain injury.
Naunyn-Schmiedeberg's archives of pharmacology, , Volume: 351, Issue:2, 1995

Role of cell adhesion molecules in brain injury after transient middle cerebral artery occlusion in the rat.
Brain research, , Sep-12, Volume: 656, Issue:2, 1994

Effect of delayed mild brain hypothermia on edema formation after intracerebral hemorrhage in rats.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 17, Issue:4

Pachymeningitis in microscopic polyangiitis (MPA): a case report and a review of central nervous system involvement in MPA.
Clinical and experimental rheumatology, , Volume: 18, Issue:3

Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells.
Clinical epigenetics, , 01-17, Volume: 11, Issue:1, 2019

A therapeutic cancer vaccine against GL261 murine glioma.
Journal of translational medicine, , Jan-05, Volume: 14, 2016

37-year-old woman with multiple intracranial masses.
Brain pathology (Zurich, Switzerland), , Volume: 21, Issue:5, 2011

Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging.
Clinical cancer research : an official journal of the American Association for Cancer Research, , Jul-01, Volume: 17, Issue:13, 2011

Vascular gene expression patterns are conserved in primary and metastatic brain tumors.
Journal of neuro-oncology, , Volume: 99, Issue:1, 2010

[Myeloid sarcoma of the brain. A case report].
Annales de pathologie, , Volume: 23, Issue:1, 2003

Effects of an intratumoral injection of human recombinant tumor necrosis factor-alpha on cerebrovascular permeability and leukocytic infiltration in a rat glioma model.
Acta neuropathologica, , Volume: 93, Issue:1, 1997

[Granulocytic sarcoma of the brain revealed on vascular mode].
Revue neurologique, , Volume: 164, Issue:6-7

Aptamer-Functionalized Ce
ACS applied materials & interfaces, , Dec-21, Volume: 14, Issue:50, 2022

Biodegradable and Peroxidase-Mimetic Boron Oxynitride Nanozyme for Breast Cancer Therapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), , Volume: 8, Issue:16, 2021

Cardiac monitoring in HER2-positive patients on trastuzumab treatment: A review and implications for clinical practice.
Breast (Edinburgh, Scotland), , Volume: 52, 2020

[Сurrent views on predictors and biomarkers of early diagnosis of anthracycline-mediated cardiotoxicity in patients with breast cancer (review of literature).]
Klinicheskaia laboratornaia diagnostika, , Volume: 65, Issue:3, 2020

Changes in Cardiovascular Biomarkers With Breast Cancer Therapy and Associations With Cardiac Dysfunction.
Journal of the American Heart Association, , 01-21, Volume: 9, Issue:2, 2020

Neutrophil extracellular trapping and angiogenesis biomarkers after intravenous or inhalation anaesthesia with or without intravenous lidocaine for breast cancer surgery: a prospective, randomised trial.
British journal of anaesthesia, , Volume: 125, Issue:5, 2020

Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter.
Nature communications, , 06-03, Volume: 10, Issue:1, 2019

Infiltration by myeloperoxidase-positive neutrophils is an independent prognostic factor in breast cancer.
Breast cancer research and treatment, , Volume: 177, Issue:3, 2019

High peroxidasin-like expression is a potential and independent prognostic biomarker in breast cancer.
Medicine, , Volume: 98, Issue:44, 2019

IL-1β Blockade Attenuates Thrombosis in a Neutrophil Extracellular Trap-Dependent Breast Cancer Model.
Frontiers in immunology, , Volume: 10, 2019

Inflammatory peroxidases promote breast cancer progression in mice via regulation of the tumour microenvironment.
International journal of oncology, , Volume: 50, Issue:4, 2017

[no title available]
Applied physics. B, Lasers and optics, , Volume: 122, Issue:12, 2016

SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents.
Cancer research, , 09-15, Volume: 76, Issue:18, 2016

Incidence of Malignancies in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Diagnosed Between 1991 and 2013.
Arthritis & rheumatology (Hoboken, N.J.), , Volume: 67, Issue:12, 2015

Induction of USP17 by combining BET and HDAC inhibitors in breast cancer cells.
Oncotarget, , Oct-20, Volume: 6, Issue:32, 2015

N-acetylglucosaminidase, myeloperoxidase and vascular endothelial growth factor serum levels in breast cancer patients.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 68, Issue:2, 2014

Early increases in multiple biomarkers predict subsequent cardiotoxicity in patients with breast cancer treated with doxorubicin, taxanes, and trastuzumab.
Journal of the American College of Cardiology, , Mar-04, Volume: 63, Issue:8, 2014

Cardiac biomarkers, cardiotoxicity, and active collaboration: is this the final frontier or the wave we should catch?
Journal of the American College of Cardiology, , Mar-04, Volume: 63, Issue:8, 2014

Angiogenesis genes, dietary oxidative balance and breast cancer risk and progression: the Breast Cancer Health Disparities Study.
International journal of cancer, , Feb-01, Volume: 134, Issue:3, 2014

Highly efficient colorimetric detection of target cancer cells utilizing superior catalytic activity of graphene oxide-magnetic-platinum nanohybrids.
Nanoscale, , Volume: 6, Issue:3, 2014

Menopausal status modifies breast cancer risk associated with the myeloperoxidase (MPO) G463A polymorphism in Caucasian women: a meta-analysis.
PloS one, , Volume: 7, Issue:3, 2012

Myeloperoxidase genotypes and enhanced efficacy of chemotherapy for early-stage breast cancer in SWOG-8897.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, , Oct-20, Volume: 27, Issue:30, 2009

A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk.
Breast cancer research and treatment, , Volume: 113, Issue:3, 2009

[The plasma level of sL-selectin, myeloperoxidase (MPO) and granulocyte-colony stimulating factor (G-CSF) in breast cancer patients after surgery].
Przeglad lekarski, , Volume: 66, Issue:8, 2009

Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk.
Carcinogenesis, , Volume: 30, Issue:5, 2009

Immunohistochemistry on frozen section of sentinel lymph nodes in breast cancer with improved morphology and blocking of endogenous peroxidase.
Applied immunohistochemistry & molecular morphology : AIMM, , Volume: 16, Issue:5, 2008

[The plasma level of sL-selectin, myeloperoxidase and granulocyte-colony stimulating factor (G-CSF) in breast cancer patients in the course of chemotherapy].
Przeglad lekarski, , Volume: 65, Issue:3, 2008

Polymorphisms in manganese superoxide dismutase, myeloperoxidase and glutathione-S-transferase and survival after treatment for metastatic breast cancer.
Breast cancer research and treatment, , Volume: 111, Issue:1, 2008

Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer.
Carcinogenesis, , Volume: 28, Issue:6, 2007

Granulocytic sarcoma of breast: an aleukemic presentation.
Indian journal of medical sciences, , Volume: 61, Issue:3, 2007

[Plasma granulocyte-macrophage colony stimulating factor (GM-CSF) and activity of enzymes in granulocytes of breast cancer patients].
Przeglad lekarski, , Volume: 63, Issue:8, 2006

Polymorphisms in genes related to oxidative stress (CAT, MnSOD, MPO, and eNOS) and acute toxicities from radiation therapy following lumpectomy for breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research, , Dec-01, Volume: 12, Issue:23, 2006

Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer.
Cancer research, , Feb-01, Volume: 65, Issue:3, 2005

Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), , Volume: 14, Issue:3, 2005

Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk.
Cancer research, , Oct-15, Volume: 64, Issue:20, 2004

[Granulocyte-colony stimulating factor (G-CSF) in the plasma and activity of enzymes in granulocytes of breast cancer patients].
Ginekologia polska, , Volume: 75, Issue:2, 2004

Effects of amitraz on cytochrome P450-dependent monooxygenases and estrogenic activity in MCF-7 human breast cancer cells and immature female rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 42, Issue:11, 2004

Breast cancer in association with thyroid disorders.
Breast cancer research : BCR, , Volume: 5, Issue:5, 2003

Analyses of bulky DNA adduct levels in human breast tissue and genetic polymorphisms of cytochromes P450 (CYPs), myeloperoxidase (MPO), quinone oxidoreductase (NQO1), and glutathione S-transferases (GSTs).
Mutation research, , Apr-26, Volume: 516, Issue:1-2, 2002

Single nucleotide polymorphisms, metabolic activation and environmental carcinogenesis: why molecular epidemiologists should think about enzyme expression.
Carcinogenesis, , Volume: 22, Issue:2, 2001

Inhibition of carcinogen-induced rat mammary tumor growth and other estrogen-dependent responses by symmetrical dihalo-substituted analogs of diindolylmethane.
Cancer letters, , Apr-14, Volume: 151, Issue:2, 2000

Amplification units and translocation at chromosome 17q and c-erbB-2 overexpression in the pathogenesis of breast cancer.
Virchows Archiv : an international journal of pathology, , Volume: 430, Issue:5, 1997

Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism.
Endocrinology, , Volume: 138, Issue:4, 1997

Bone marrow changes induced by recombinant granulocyte colony-stimulating factor resembling metastatic carcinoma: distinction with cytochemical and immunohistochemical studies.
American journal of hematology, , Volume: 51, Issue:4, 1996

The role of peroxidase-catalyzed activation of aromatic amines in breast cancer.
Mutagenesis, , Volume: 11, Issue:1, 1996

Occult deposition of eosinophil peroxidase in a subset of human breast carcinomas.
The American journal of pathology, , Volume: 148, Issue:3, 1996

Review of the effects of dietary fat on experimental mammary gland tumorigenesis: role of lipid peroxidation.
Free radical biology & medicine, , Volume: 18, Issue:4, 1995

Localization of the human estrogen-responsive finger protein (EEP) gene (ZNF147) within a YAC contig containing the myeloperoxidase (MPO) gene.
Genomics, , Jul-20, Volume: 28, Issue:2, 1995

Improved quantitation of HER-2/neu gene copy number in breast tumor-derived DNA samples.
American journal of clinical pathology, , Volume: 100, Issue:4, 1993

The distribution of lectin receptor sites in human breast lesions.
Pathology, research and practice, , Volume: 183, Issue:4, 1988

Human breast cancer cells synthesize and secrete an EGF-like immunoreactive factor in culture.
Biochemical and biophysical research communications, , Apr-14, Volume: 136, Issue:1, 1986

Peroxidase activity and estradiol receptors in human breast cancer.
Clinica chimica acta; international journal of clinical chemistry, , Mar-28, Volume: 155, Issue:3, 1986

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TPL2 Is a Key Regulator of Intestinal Inflammation in Clostridium difficile Infection.
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Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models.
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Precancerous ACF induction affects their regional distribution forsaking oxidative stress implication in 1,2-dimethylhydrazine-induced colon carcinogenesis model.
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Goniothalamin prevents the development of chemically induced and spontaneous colitis in rodents and induces apoptosis in the HT-29 human colon tumor cell line.
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Targeted anti-colon cancer activities of a millet bran-derived peroxidase were mediated by elevated ROS generation.
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Dietary Fiber Intake is Associated with Increased Colonic Mucosal GPR43+ Polymorphonuclear Infiltration in Active Crohn's Disease.
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Influence of myeloperoxidase on colon tumor occurrence in inflamed versus non-inflamed colons of Apc(Min/+) mice.
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Adenovirus-mediated hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein suppresses dextran sulfate sodium-induced acute ulcerative colitis in rats.
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Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.
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Fluoxetine inhibits NF-κB signaling in intestinal epithelial cells and ameliorates experimental colitis and colitis-associated colon cancer in mice.
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The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signaling.
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3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice.
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Dietary fiber down-regulates colonic tumor necrosis factor alpha and nitric oxide production in trinitrobenzenesulfonic acid-induced colitic rats.
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Colon epithelial cellular protein induces oral tolerance in the experimental model of colitis by trinitrobenzene sulfonic acid.
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Alkali-catalyzed beta-elimination of periodate-oxidized glycans: a novel method of chemical deglycosylation of mucin gene products in paraffin embedded sections.
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Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene.
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CD10 inhibitors increase f-Met-Leu-Phe-induced neutrophil transmigration.
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Effects of the common cold and intranasal fluticasone propionate treatment on mucosal host defense assessed by human saliva.
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Influenza Virus Infection Increases Host Susceptibility To Secondary Infection with Pseudomonas aeruginosa, and This Is Attributed To Neutrophil Dysfunction through Reduced Myeloperoxidase Activity.
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The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases.
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N-acetylcysteine protects striated muscle in a model of compartment syndrome.
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Octreotide improves reperfusion-induced oxidative injury in acute abdominal hypertension in rats.
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Oral vitamin C reduces the injury to skeletal muscle caused by compartment syndrome.
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Melatonin ameliorates oxidative organ damage induced by acute intra-abdominal compartment syndrome in rats.
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Tear and serum soluble leukocyte activation markers in conjunctival allergic diseases.
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MPO-ANCA-positive granulomatosis with polyangiitis and concurrent IgG4-related disease with periaortitis and tubulointerstitial nephritis: A case report of a new overlap syndrome?
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Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis.
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Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis.
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Attenuating effect of Acorus calamus extract in chronic constriction injury induced neuropathic pain in rats: an evidence of anti-oxidative, anti-inflammatory, neuroprotective and calcium inhibitory effects.
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Anti-inflammatory and antinociceptive properties of blueberry extract (Vaccinium corymbosum).
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Circulation research, , Mar-04, Volume: 96, Issue:4, 2005

A case of pulmonary arteritis with stenosis of the main pulmonary arteries with positive myeloperoxidase-antineutrophil cytoplasmic autoantibodies.
Respirology (Carlton, Vic.), , Volume: 5, Issue:4, 2000

Tacrolimus suppresses tumour necrosis factor-alpha and protects against splanchnic artery occlusion shock.
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Effects of penehyclidine hydrochloride on pulmonary contusion from blunt chest trauma in rats.
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Aging-associated oxidative stress modulates the acute inflammatory response in skeletal muscle after contusion injury.
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Predictive modeling and inflammatory biomarkers in rats with lung contusion and gastric aspiration.
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Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion.
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The use of flow cytometry to assess neutrophil infiltration in the injured murine spinal cord.
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Protein kinase inhibition by fasudil hydrochloride promotes neurological recovery after spinal cord injury in rats.
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Peripheral ulcerative keratitis as the first and only manifestation of MPO-ANCA-associated vasculitis.
Rheumatology (Oxford, England), , 12-01, Volume: 62, Issue:12, 2023

Peripheral ulcerative keratitis in children owing to P-ANCA-associated vasculitis.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, , Volume: 55, Issue:5, 2020

ISG15 Acts as a Mediator of Innate Immune Response to Pseudomonas aeruginosa Infection in C57BL/6J Mouse Corneas.
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The role of CXC chemokine receptor 2 in Staphylococcus aureus keratitis.
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Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection.
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Cathelicidin-deficient (Cnlp -/- ) mice show increased susceptibility to Pseudomonas aeruginosa keratitis.
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Effects of alpha-toxin-deficient Staphylococcus aureus on the production of peripheral corneal ulceration in an animal model.
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Evidence for TIMP-1 protection against P. aeruginosa-induced corneal ulceration and perforation.
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Cardioprotective Effects of Nicorandil on Coronary Heart Disease Patients Undergoing Elective Percutaneous Coronary Intervention.
Medical science monitor : international medical journal of experimental and clinical research, , Jun-15, Volume: 23, 2017

Exercise-based rehabilitation improves cardiorespiratory fitness but does not modulate myeloperoxidase levels in coronary heart disease patients.
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Accumulation of oxidative stress-related gene polymorphisms and the risk of coronary heart disease events in patients with type 2 diabetes--an 8-year prospective study.
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Bulletin of experimental biology and medicine, , Volume: 155, Issue:1, 2013

[Change of serum myeloperoxidase and lipoxin A4 level in coronary heart disease patients with anxiety and/or depression].
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Leukocyte and leukocyte subset counts reveal compensatory mechanisms in coronary heart disease.
Clinica chimica acta; international journal of clinical chemistry, , Mar-15, Volume: 418, 2013

Elevated serum myeloperoxidase activities are significantly associated with the prevalence of ACS and High LDL-C levels in CHD patients.
Journal of atherosclerosis and thrombosis, , Volume: 19, Issue:5, 2012

Myeloperoxidase is associated with incident coronary heart disease independently of traditional risk factors: results from the MONICA/KORA Augsburg study.
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Functional activity of neutrophils in diabetes mellitus and coronary heart disease: role of myeloperoxidase in the development of oxidative stress.
Bulletin of experimental biology and medicine, , Volume: 154, Issue:1, 2012

Inflammatory biomarkers, physical activity, waist circumference, and risk of future coronary heart disease in healthy men and women.
European heart journal, , Volume: 32, Issue:3, 2011

Current role of myeloperoxidase in routine clinical practice.
Expert review of cardiovascular therapy, , Volume: 9, Issue:2, 2011

[Parameters of platelets activation and myeloperoxidase concentration as markers of coronary disease].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, , Volume: 29, Issue:172, 2010

The effects of G-CSF-induced mobilization of progenitor cells are limited by ADMA.
International journal of cardiology, , Sep-03, Volume: 143, Issue:3, 2010

Inflammatory biomarkers and coronary heart disease: from bench to bedside and back.
Internal and emergency medicine, , Volume: 5, Issue:3, 2010

[Neutrophilic intracellular metabolic changes and fatal outcome in coronary heart disease].
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Can endogenous lipid molecules serve as predictors and prognostic markers of coronary heart disease?
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A pilot-controlled study of myeloperoxidase-specific anti-neutrophil cytoplasmic autoantibody (MPO-ANCA) in the coronary circulation.
International journal of cardiology, , Aug-01, Volume: 128, Issue:1, 2008

Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study.
Biological psychiatry, , Sep-15, Volume: 64, Issue:6, 2008

Toll-like receptors 2-deficient mice are protected against postischemic coronary endothelial dysfunction.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 27, Issue:5, 2007

The pleiotropic effect of statins in haemodialysis patients is not the consequence of an inhibition of LDL oxidation by myeloperoxidase.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 21, Issue:9, 2006

Multimarker panel to rule out acute coronary syndromes in low-risk patients.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, , Volume: 13, Issue:7, 2006

The effect of atorvastatin on serum myeloperoxidase and CRP levels in patients with acute coronary syndrome.
Clinica chimica acta; international journal of clinical chemistry, , Volume: 368, Issue:1-2, 2006

Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome.
Clinical chemistry, , Volume: 51, Issue:5, 2005

Clearing a path for new cardiac markers.
CAP today, , Volume: 19, Issue:2, 2005

Markers for early detection of cardiac diseases.
Scandinavian journal of clinical and laboratory investigation. Supplementum, , Volume: 240, 2005

Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.
The Journal of thoracic and cardiovascular surgery, , Volume: 129, Issue:5, 2005

Inflammation, atherosclerosis, and coronary artery disease.
The New England journal of medicine, , Jul-28, Volume: 353, Issue:4, 2005

Overexpression of human copper/zinc superoxide dismutase (SOD1) suppresses ischemia-reperfusion injury and subsequent development of graft coronary artery disease in murine cardiac grafts.
Circulation, , Sep-14, Volume: 110, Issue:11 Suppl 1, 2004

Incorporating cardiovascular disease risk stratification into clinical decision making.
JAAPA : official journal of the American Academy of Physician Assistants, , Volume: 17, Issue:5, 2004

The year in atherothrombosis.
Journal of the American College of Cardiology, , Dec-07, Volume: 44, Issue:11, 2004

Myeloperoxidase polymorphism related to cardiovascular events in coronary artery disease.
The American journal of medicine, , Mar-15, Volume: 116, Issue:6, 2004

Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts.
Circulation, , Sep-14, Volume: 110, Issue:11 Suppl 1, 2004

New marker in acute coronary syndromes.
Circulation, , Sep-23, Volume: 108, Issue:12, 2003

Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes.
Circulation, , Sep-23, Volume: 108, Issue:12, 2003

Assessment of myocardial inflammation produced by experimental coronary occlusion and reperfusion with 99mTc-RP517, a new leukotriene B4 receptor antagonist that preferentially labels neutrophils in vivo.
Circulation, , Jul-30, Volume: 106, Issue:5, 2002

The reduction of myocardial damage and leukocyte polymorphonuclear accumulation following coronary artery occlusion by the tyrosine kinase inhibitor tyrphostin AG 556.
Life sciences, , Oct-13, Volume: 67, Issue:21, 2000

Long-term probucol treatment reverses the severity of myocardial injury in watanabe heritable hyperlipidemic rabbits.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 17, Issue:11, 1997

Prevention of coronary vascular abnormalities early in reperfusion with TGF-beta may not prevent late coronary vascular injury.
Journal of cardiovascular pharmacology, , Volume: 30, Issue:2, 1997

Adenosine protects against attenuation of flow reserve and myocardial function after coronary occlusion and reperfusion.
American heart journal, , Volume: 127, Issue:5, 1994

Contribution of leukocyte infiltration to lipoperoxidation occurring in the non-ischemic region of the rat heart submitted to permanent left coronary artery occlusion.
Journal of molecular and cellular cardiology, , Volume: 26, Issue:7, 1994

G619, a dual thromboxane synthase inhibitor and thromboxane A2 receptor antagonist, reduces myocardial damage and polymorphonuclear leukocyte accumulation following coronary artery occlusion and reperfusion in rats.
Pharmacology, , Volume: 47, Issue:3, 1993

The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat.
Circulation, , Volume: 86, Issue:1, 1992

Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs.
Circulation research, , Volume: 70, Issue:2, 1992

Endothelial dysfunction in myocardial ischemia and reperfusion: role of oxygen-derived free radicals.
Basic research in cardiology, , Volume: 86 Suppl 2, 1991

Time course of endothelial dysfunction and myocardial injury during coronary arterial occlusion.
The American journal of physiology, , Volume: 261, Issue:3 Pt 2, 1991

Cardioprotective and endothelial protective effects of [Ala-IL8]77 in a rabbit model of myocardial ischaemia and reperfusion.
British journal of pharmacology, , Volume: 103, Issue:1, 1991

Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion.
The Journal of clinical investigation, , Volume: 88, Issue:4, 1991

Reduction in myocardial ischemic/reperfusion injury and neutrophil accumulation after therapeutic administration of streptokinase.
Journal of cardiovascular pharmacology, , Volume: 18, Issue:5, 1991

Endothelium and myocardial protecting actions of taprostene, a stable prostacyclin analogue, after acute myocardial ischemia and reperfusion in cats.
Circulation research, , Volume: 66, Issue:5, 1990

TxA2 inhibition and ischemia-induced loss of myocardial function and reactive hyperemia.
The American journal of physiology, , Volume: 258, Issue:5 Pt 2, 1990

Evaluation of the effect of azapropazone on neutrophil migration in regional myocardial ischaemia/reperfusion injury in rabbits.
British journal of pharmacology, , Volume: 100, Issue:2, 1990

[The cytochemical characteristics of the blood leukocytes in inflammatory lesions of the myocardium].
Vrachebnoe delo, , Issue:12, 1990

Cardioprotective effects of acidified sodium nitrite in myocardial ischemia with reperfusion.
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Synergism between superoxide dismutase and sodium nitrite in cardioprotection following ischemia and reperfusion.
American heart journal, , Volume: 119, Issue:3 Pt 1, 1990

[Granulocyte alkaline phosphatase and myeloperoxidase in patients with ischemic heart disease].
Vrachebnoe delo, , Issue:3, 1989

Reduction in coronary vasodilator reserve following coronary occlusion and reperfusion in anesthetized dog: role of endothelium-derived relaxing factor, myocardial neutrophil infiltration and prostaglandins.
Journal of molecular and cellular cardiology, , Volume: 20, Issue:10, 1988

Enzymic determination of the free cholesterol fraction of high-density lipoprotein in plasma with use of 2,4,6-tribromo-3-hydroxybenzoic acid.
Clinical chemistry, , Volume: 34, Issue:9, 1988

Identification of a time window for therapy to reduce experimental canine myocardial injury: suppression of neutrophil activation during 72 hours of reperfusion.
Circulation research, , Volume: 63, Issue:6, 1988

Protection of the ischemic myocardium from reperfusion injury by prostaglandin E1 inhibition of ischemia-induced neutrophil activation.
Naunyn-Schmiedeberg's archives of pharmacology, , Volume: 338, Issue:3, 1988

Activation of inflammatory systems during cardiopulmonary bypass.
Scandinavian journal of thoracic and cardiovascular surgery, , Volume: 22, Issue:1, 1988

Temporal relation between neutrophil accumulation and myocardial reperfusion injury.
The American journal of physiology, , Volume: 255, Issue:5 Pt 2, 1988

Cardioplegic arrest superimposed on evolving myocardial ischemia. Improved recovery after inhibition of hydroxyl radical generation by peroxidase or deferoxamine. A 31P nuclear resonance study.
Circulation, , Volume: 78, Issue:5 Pt 2, 1988

Role of neutrophils in ischemic heart disease: pathophysiologic role in myocardial ischemia and coronary artery reperfusion.
Cardiovascular clinics, , Volume: 18, Issue:1, 1987

Regulation of prostacyclin production by vascular cells in in vitro and in vivo experimentals systems.
Wiener klinische Wochenschrift, , Apr-04, Volume: 98, Issue:7, 1986

Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium.
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[Characteristics of cardiac rhythm and the peroxidase activity of blood in patients with ischemic heart disease treated by hyperbaric oxygenation].
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Pulmonary manifestations and outcomes in paediatric ANCA-associated vasculitis: a single-centre experience.
Rheumatology (Oxford, England), , 07-01, Volume: 60, Issue:7, 2021

Case 32-2017. A 64-Year-Old Man with Dyspnea, Wheezing, Headache, Cough, and Night Sweats.
The New England journal of medicine, , 10-19, Volume: 377, Issue:16, 2017

Clinical features of children with pulmonary microscopic polyangiitis: report of 9 cases.
PloS one, , Volume: 10, Issue:4, 2015

Naringin attenuates enhanced cough, airway hyperresponsiveness and airway inflammation in a guinea pig model of chronic bronchitis induced by cigarette smoke.
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Eosinophil degranulation is more important than eosinophilia in identifying asthma in chronic cough.
The Journal of asthma : official journal of the Association for the Care of Asthma, , Volume: 48, Issue:10, 2011

Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency.
Respiratory medicine, , Volume: 100, Issue:6, 2006

Pulmonary function is negatively correlated with sputum inflammatory markers and cough clearability in subjects with cystic fibrosis but not those with chronic bronchitis.
Chest, , Volume: 129, Issue:5, 2006

Effects of montelukast treatment on clinical and inflammatory variables in patients with cystic fibrosis.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, , Volume: 95, Issue:4, 2005

Eosinophilic airway inflammation as an underlying mechanism of undiagnosed prolonged cough in primary healthcare patients.
Respiratory medicine, , Volume: 96, Issue:1, 2002

A case of pulmonary arteritis with stenosis of the main pulmonary arteries with positive myeloperoxidase-antineutrophil cytoplasmic autoantibodies.
Respirology (Carlton, Vic.), , Volume: 5, Issue:4, 2000

[Oxidase and whooping-cough; its study in treatment by high altitude flying].
Revue de medecine aeronautique, , Volume: 2, Issue:3, 1950

The acute-phase response and serum amyloid A inhibit the inflammatory response to Acinetobacter baumannii Pneumonia.
The Journal of infectious diseases, , Jan-15, Volume: 193, Issue:2, 2006

Vasculitic neuropathy: Comparison of clinical predictors with histopathological outcome.
Muscle & nerve, , Volume: 59, Issue:6, 2019

An Autopsy Case of Myeloperoxidase-anti-neutrophil Cytoplasmic Antibody (MPO-ANCA)-associated Vasculitis Accompanied by Cryoglobulinemic Vasculitis Affecting the Kidneys, Skin, and Gastrointestinal Tract.
Internal medicine (Tokyo, Japan), , Sep-15, Volume: 57, Issue:18, 2018

Antinuclear Antibody-Negative Lupus Nephritis with Full House Nephropathy: A Case Report and Review of the Literature.
American journal of nephrology, , Volume: 42, Issue:6, 2015

New algorithm (KAWAKAMI algorithm) to diagnose primary cutaneous vasculitis.
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[A case of MPO-ANCA-related microscopic polyangiitis with mixed cryoglobulinemia].
Nihon Jinzo Gakkai shi, , Volume: 48, Issue:4, 2006

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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Developing Pancreatic Lesion and Diabetes Mellitus: A Case Report and Review of the Literature.
The Tohoku journal of experimental medicine, , Volume: 256, Issue:2, 2022

Impairment of renal steroidogenesis at the onset of diabetes.
Molecular and cellular endocrinology, , 03-15, Volume: 524, 2021

Process, Outcomes and Possible Elimination of Aggregation with Special Reference to Heme Proteins; Likely Remediations of Proteinopathies.
Current protein & peptide science, , Volume: 21, Issue:6, 2020

Microvascular disease confers additional risk to COVID-19 infection.
Medical hypotheses, , Volume: 144, 2020

Knowledge of an inflammatory biomarker of cardiovascular risk leads to biomarker-based decreased risk in pre-diabetic and diabetic patients.
The Journal of international medical research, , Volume: 48, Issue:1, 2020

Cobalt oxyhydroxide nanoflakes with intrinsic peroxidase catalytic activity and their application to serum glucose detection.
Analytical and bioanalytical chemistry, , Volume: 409, Issue:17, 2017

Selected antibacterial factors in the saliva of diabetic patients.
Archives of oral biology, , Volume: 60, Issue:3, 2015

Myeloperoxidase levels predict accelerated progression of coronary atherosclerosis in diabetic patients: insights from intravascular ultrasound.
Atherosclerosis, , Volume: 232, Issue:2, 2014

Seeing diabetes: visual detection of glucose based on the intrinsic peroxidase-like activity of MoS2 nanosheets.
Nanoscale, , Oct-21, Volume: 6, Issue:20, 2014

Genotype-dependent impairment of hemoglobin clearance increases oxidative and inflammatory response in human diabetic atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 32, Issue:11, 2012

Adaptation of the Diazyme Direct Enzymatic HbA1c Assay for a microplate reader at room temperature.
Clinical chemistry and laboratory medicine, , Volume: 49, Issue:7, 2011

Enhanced tyrosine nitration of prostacyclin synthase is associated with increased inflammation in atherosclerotic carotid arteries from type 2 diabetic patients.
The American journal of pathology, , Volume: 176, Issue:5, 2010

Fructose-induced structural and functional modifications of hemoglobin: implication for oxidative stress in diabetes mellitus.
Biochimica et biophysica acta, , Volume: 1780, Issue:5, 2008

Oxidative stress and endothelial dysfunction in vascular disease.
Current diabetes reports, , Volume: 7, Issue:4, 2007

New enzymatic assay for glycohemoglobin.
Clinical chemistry, , Volume: 49, Issue:2, 2003

Accelerated wound closure in neutrophil-depleted mice.
Journal of leukocyte biology, , Volume: 73, Issue:4, 2003

Cholesterol feeding exacerbates myocardial injury in Zucker diabetic fatty rats.
American journal of physiology. Heart and circulatory physiology, , Volume: 278, Issue:1, 2000

Effects of insulin on N-formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe)-stimulated production of reactive oxygen metabolites from normal human neutrophils.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 48, Issue:7, 1999

[Myeloperoxidase].
Nihon rinsho. Japanese journal of clinical medicine, , Volume: 56 Suppl 3, 1998

[The activity of cationic proteins, peroxidase and alkaline phosphatase in the blood neutrophils of diabetics].
Vrachebnoe delo, , Issue:11, 1989

Bactericidal proteins and neutral proteases in diabetes neutrophils.
Diabetologia, , Volume: 29, Issue:7, 1986

A simple colorimetric method for spot blood glucose estimation.
Annals of clinical biochemistry, , Volume: 22 ( Pt 6), 1985

Cytochemical indices of leukocytes in patients with diabetes mellitus.
Folia haematologica (Leipzig, Germany : 1928), , Volume: 112, Issue:1, 1985

Acquired neutrophil myeloperoxidase deficiency: an indicator of subclinical activation of blood coagulation?
Blood cells, , Volume: 9, Issue:3, 1983

Interaction of beta 1-anticollagenase from human plasma with collagenases from various tissues and competition with alpha 2-macroglobulin.
European journal of biochemistry, , Jan-17, Volume: 130, Issue:1, 1983

Partial myeloperoxidase deficiency.
Acta haematologica, , Volume: 67, Issue:3, 1982

Comparison of two methods of blood glucose determination: reagent-strip method and modified single glucose oxidase-peroxidase method.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, , Volume: 65, Issue:1, 1982

[Enzymes and cytochemical indices of the peripheral blood neutrophilic granulocytes in diabetics].
Folia medica Cracoviensia, , Volume: 23, Issue:2, 1981

[Phagocytosis.-II. Pathology].
Revista clinica espanola, , Oct-31, Volume: 143, Issue:2, 1976

Inhibition of myeloperoxidase increases revascularization and improves blood flow in a diabetic mouse model of hindlimb ischaemia.
Diabetes & vascular disease research, , Volume: 17, Issue:3

Modulatory effects of caffeic acid on purinergic and cholinergic systems and oxi-inflammatory parameters of streptozotocin-induced diabetic rats.
Life sciences, , Jul-15, Volume: 277, 2021

NETosis in Long-Term Type 1 Diabetes Mellitus and Its Link to Coronary Artery Disease.
Frontiers in immunology, , Volume: 12, 2021

Improvement of Cutaneous Wound Healing via Topical Application of Heat-Killed
Nutrients, , Jul-31, Volume: 13, Issue:8, 2021

Gluten intake and risk of thyroid peroxidase autoantibodies in the Diabetes Autoimmunity Study In the Young (DAISY).
Endocrine, , Volume: 70, Issue:2, 2020

Elevated Leukocyte Azurophilic Enzymes in Human Diabetic Ketoacidosis Plasma Degrade Cerebrovascular Endothelial Junctional Proteins.
Critical care medicine, , Volume: 44, Issue:9, 2016

Hypoxia-induced acute lung injury is aggravated in streptozotocin diabetic mice.
Experimental lung research, , Volume: 41, Issue:3, 2015

Assessment of anti-diabetic activity of an ethnopharmacological plant Nerium oleander through alloxan induced diabetes in mice.
Journal of ethnopharmacology, , Feb-23, Volume: 161, 2015

Paraoxonase lactonase activity, inflammation and antioxidant status in plasma of patients with type 1 diabetes mellitus.
The Journal of international medical research, , Volume: 42, Issue:2, 2014

Eosinophils from patients with type 1 diabetes mellitus express high level of myeloid alpha-defensins and myeloperoxidase.
Cellular immunology, , Volume: 273, Issue:2, 2012

Altered inflammatory, oxidative, and metabolic responses to exercise in pediatric obesity and type 1 diabetes.
Pediatric diabetes, , Volume: 12, Issue:5, 2011

[A case of slowly progressive type 1 diabetes mellitus developing myeloperoxidase-specific anti-neutrophil cytoplasmic antibody-associated vasculitis with hypertrophic pachymeningitis manifesting as multiple cranial nerve palsy].
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, , Volume: 34, Issue:6, 2011

Discovery and validation of serum protein changes in type 1 diabetes patients using high throughput two dimensional liquid chromatography-mass spectrometry and immunoassays.
Molecular & cellular proteomics : MCP, , Volume: 10, Issue:11, 2011

Effect of long- and short-term treatments with pravastatin on diabetes mellitus and pancreatic fibrosis in the Otsuka-Long-Evans-Tokushima fatty rat.
British journal of pharmacology, , Jan-01, Volume: 159, Issue:2, 2010

Frequency of anti-glutamic acid decarboxylase and anti-thyroperoxidase autoantibodies in siblings of patients with diabetes diagnosed in adult life.
International journal of clinical practice, , Volume: 63, Issue:3, 2009

Arterial stiffness, carotid artery intima-media thickness and plasma myeloperoxidase level in children with type 1 diabetes.
Diabetes research and clinical practice, , Volume: 84, Issue:2, 2009

Invertase, maltase, lactase, and peroxidase activities in duodenum of BB rats.
Endocrine, , Volume: 19, Issue:3, 2002

The evaluation of thyroid and islet autoantibodies in type 1 diabetes mellitus.
Sbornik lekarsky, , Volume: 100, Issue:3, 1999

Detection of anti-myeloperoxidase antibodies in the serum of patients with type 1 diabetes mellitus.
Acta diabetologica, , Volume: 33, Issue:2, 1996

A quantitative immunocytochemical method for the measurement of islet cell cytoplasmic antibodies.
Journal of immunological methods, , Apr-27, Volume: 149, Issue:1, 1992

[Myeloperoxidase activity and glycogen levels in peripheral blood neutrophils in patients with well controlled diabetes mellitus type 1 and 2].
Polski tygodnik lekarski (Warsaw, Poland : 1960), , Mar-07, Volume: 43, Issue:10, 1988

Assay for islet cell antibodies with rat pancreas and peroxidase protein A.
Diabetes care, , Volume: 11, Issue:4, 1988

[Blood monocytes in type-1 diabetes mellitus: electron microscopic and ultracytochemical studies].
Terapevticheskii arkhiv, , Volume: 60, Issue:5, 1988

Endocrine autoimmunity in young patients with juvenile chronic arthritis.
Clinical and experimental rheumatology, , Volume: 20, Issue:4

[System of lipid peroxidation--antioxidant protection and the role of its disorders in the pathogenesis of diabetes mellitus and angiopathy].
Problemy endokrinologii, , Volume: 39, Issue:1

Associations between myeloperoxidase and paraoxonase-1 and type 2 diabetes in patients with ischemic heart disease.
BMC cardiovascular disorders, , 12-03, Volume: 22, Issue:1, 2022

Increased concentrations of myeloperoxidase in serum and serum extracellular vesicles are associated with type 2 diabetes mellitus.
Clinica chimica acta; international journal of clinical chemistry, , Volume: 522, 2021

Metformin Is Associated with Reduced Tissue Factor Procoagulant Activity in Patients with Poorly Controlled Diabetes.
Cardiovascular drugs and therapy, , Volume: 35, Issue:4, 2021

Neutrophil degranulation biomarkers characterize restrictive echocardiographic pattern with diastolic dysfunction in patients with diabetes.
European journal of clinical investigation, , Volume: 51, Issue:12, 2021

Different roles of intracellular and extracellular reactive oxygen species of neutrophils in type 2 diabetic mice with invasive aspergillosis.
Immunobiology, , Volume: 225, Issue:5, 2020

Clinically feasible method for assessing leukocyte rheology in whole blood.
Heart and vessels, , Volume: 35, Issue:2, 2020

Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes.
Scientific reports, , 04-10, Volume: 10, Issue:1, 2020

Levels of Myeloperoxidase and Metalloproteinase-9 in Gingival Crevicular Fluid from Diabetic Subjects with and without Stage 2, Grade B Periodontitis.
BioMed research international, , Volume: 2019, 2019

Levels of Nitric Oxide Metabolites and Myeloperoxidase in Subjects with Type 2 Diabetes Mellitus on Metformin Therapy .
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, , Volume: 127, Issue:1, 2019

Predictors of neutrophil extracellular traps markers in type 2 diabetes mellitus: associations with a prothrombotic state and hypofibrinolysis.
Cardiovascular diabetology, , 04-16, Volume: 18, Issue:1, 2019

Raffia palm (Raphia hookeri) wine extenuates redox imbalance and modulates activities of glycolytic and cholinergic enzymes in hyperglycemia-induced testicular injury in type 2 diabetic rats.
Journal of food biochemistry, , Volume: 43, Issue:3, 2019

Evaluation of the oxidative stress-related genes ALOX5, ALOX5AP, GPX1, GPX3 and MPO for contribution to the risk of type 2 diabetes mellitus in the Han Chinese population.
Diabetes & vascular disease research, , Volume: 15, Issue:4, 2018

[Neutrophils as a source of factors that increase the length of the inflammatory phase of wound healing in patients with type 2 diabetes mellitus].
Biomeditsinskaia khimiia, , Volume: 64, Issue:5, 2018

Myeloperoxidase, superoxide dismutase-3, cardiometabolic risk factors, and distal sensorimotor polyneuropathy: The KORA F4/FF4 study.
Diabetes/metabolism research and reviews, , Volume: 34, Issue:5, 2018

Comparison of Diabetic and Non-diabetic Human Leukocytic Responses to Different Capsule Types of
Frontiers in cellular and infection microbiology, , Volume: 7, 2017

Association of serum levels of anti-myeloperoxidase antibody with retinal photoreceptor ellipsoid zone disruption in diabetic retinopathy.
Journal of diabetes and its complications, , Volume: 31, Issue:5, 2017

ANCA and IgA glomerulonephritis all in one: prognosis and complications.
BMJ case reports, , Oct-09, Volume: 2017, 2017

Insulin enhances the peroxidase activity of heme by forming heme-insulin complex: Relevance to type 2 diabetes mellitus.
International journal of biological macromolecules, , Volume: 102, 2017

Olmesartan Combined With Amlodipine on Oxidative Stress Parameters in Type 2 Diabetics, Compared With Single Therapies: A Randomized, Controlled, Clinical Trial.
Medicine, , Volume: 95, Issue:13, 2016

Role of Myeloperoxidase in Patients with Chronic Kidney Disease.
Oxidative medicine and cellular longevity, , Volume: 2016, 2016

Emerging Cardiovascular Disease Biomarkers and Incident Diabetes Mellitus Risk in Statin-Treated Patients With Coronary Artery Disease (from the Treating to New Targets [TNT] Study).
The American journal of cardiology, , 08-15, Volume: 118, Issue:4, 2016

Circulating Neutrophil Extracellular Trap Levels in Well-Controlled Type 2 Diabetes and Pathway Involved in Their Formation Induced by High-Dose Glucose.
Pathobiology : journal of immunopathology, molecular and cellular biology, , Volume: 83, Issue:5, 2016

Association of novel metrics of particulate matter with vascular markers of inflammation and coagulation in susceptible populations -results from a panel study.
Environmental research, , Volume: 150, 2016

Association of Plasma Myeloperoxidase Level with Risk of Coronary Artery Disease in Patients with Type 2 Diabetes.
Disease markers, , Volume: 2015, 2015

Myeloperoxidase-mediated oxidation targets serum apolipoprotein A-I in diabetic patients and represents a potential mechanism leading to impaired anti-apoptotic activity of high density lipoprotein.
Clinica chimica acta; international journal of clinical chemistry, , Feb-20, Volume: 441, 2015

Oxidized HDL and LDL in adolescents with type 2 diabetes compared to normal weight and obese peers.
Journal of diabetes and its complications, , Volume: 29, Issue:5, 2015

Troponin in diabetic patients with and without chronic coronary artery disease.
BMC cardiovascular disorders, , Jul-21, Volume: 15, 2015

Carbamylation of LDL and its relationship with myeloperoxidase in type 2 diabetes mellitus.
Clinical science (London, England : 1979), , Volume: 126, Issue:2, 2014

Accumulation of oxidative stress-related gene polymorphisms and the risk of coronary heart disease events in patients with type 2 diabetes--an 8-year prospective study.
Atherosclerosis, , Volume: 235, Issue:2, 2014

An association between MPO -463 G/A polymorphism and type 2 diabetes.
Folia biologica, , Volume: 60, Issue:3, 2014

Associations between ambient air pollution and blood markers of inflammation and coagulation/fibrinolysis in susceptible populations.
Environment international, , Volume: 70, 2014

Measurement of plasma hemoglobin peroxidase activity.
Bulletin of experimental biology and medicine, , Volume: 155, Issue:1, 2013

Trans-vessel gradient of myeloperoxidase in coronary artery disease.
European journal of clinical investigation, , Volume: 43, Issue:9, 2013

Heme bound amylin: spectroscopic characterization, reactivity, and relevance to type 2 diabetes.
Inorganic chemistry, , May-06, Volume: 52, Issue:9, 2013

Is myeloperoxidase a key component in the ROS-induced vascular damage related to nephropathy in type 2 diabetes?
Antioxidants & redox signaling, , Nov-01, Volume: 19, Issue:13, 2013

Association of myeloperoxidase G-463A gene polymorphism with diabetic nephropathy in Japanese type 2 diabetic subjects.
Endocrine journal, , Volume: 60, Issue:4, 2013

Functional activity of neutrophils in diabetes mellitus and coronary heart disease: role of myeloperoxidase in the development of oxidative stress.
Bulletin of experimental biology and medicine, , Volume: 154, Issue:1, 2012

Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes.
Regulatory peptides, , Jan-17, Volume: 166, Issue:1-3, 2011

Myeloperoxidase is not associated with scintigraphic myocardial perfusion abnormalities in type 2 diabetic patients with mild stable anginal complaints.
Clinica chimica acta; international journal of clinical chemistry, , Jan-14, Volume: 412, Issue:1-2, 2011

Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy.
Circulation, , Jan-05, Volume: 121, Issue:1, 2010

Lactoferrin is a novel predictor of fatal ischemic heart disease in diabetes mellitus type 2: long-term follow-up of the HUNT 1 study.
Atherosclerosis, , Volume: 212, Issue:2, 2010

Hyperglycemia and oxidative stress strengthen the association between myeloperoxidase and blood pressure.
Hypertension (Dallas, Tex. : 1979), , Volume: 55, Issue:6, 2010

Enhanced tyrosine nitration of prostacyclin synthase is associated with increased inflammation in atherosclerotic carotid arteries from type 2 diabetic patients.
The American journal of pathology, , Volume: 176, Issue:5, 2010

Combined effect of oxidative stress-related gene polymorphisms on atherosclerosis.
Biochemical and biophysical research communications, , Feb-20, Volume: 379, Issue:4, 2009

Myeloperoxidase and paraoxonase-1 in type 2 diabetic patients.
Nutrition, metabolism, and cardiovascular diseases : NMCD, , Volume: 19, Issue:9, 2009

The common G-866A polymorphism of the UCP2 gene and survival in diabetic patients following myocardial infarction.
Cardiovascular diabetology, , Jun-15, Volume: 8, 2009

The effect of non-surgical periodontal therapy on peroxidase activity in diabetic patients: a case-control pilot study.
Journal of clinical periodontology, , Volume: 35, Issue:9, 2008

[Intervention effect of ganoderma lucidum spores on the changes of XOD, MPO and SDH in the testis tissue of NIDDM rats].
Zhonghua nan ke xue = National journal of andrology, , Volume: 14, Issue:9, 2008

Diabetes mellitus type 2 is associated with higher levels of myeloperoxidase.
Medical science monitor : international medical journal of experimental and clinical research, , Volume: 14, Issue:8, 2008

Comparison of two consecutive fat-rich and carbohydrate-rich meals on postprandial myeloperoxidase response in women with and without type 2 diabetes mellitus.
Metabolism: clinical and experimental, , Volume: 57, Issue:2, 2008

The association of myeloperoxidase promoter polymorphism with carotid atherosclerosis is abolished in patients with type 2 diabetes.
Clinical biochemistry, , Volume: 41, Issue:7-8, 2008

High molecular weight adiponectin correlates positively with myeloperoxidase in patients with type 2 diabetes mellitus.
Diabetes research and clinical practice, , Volume: 82, Issue:2, 2008

Effect of PPAR-gamma agonist treatment on markers of endothelial dysfunction in patients with type 2 diabetes mellitus.
Physiological research, , Volume: 56, Issue:6, 2007

Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction.
Journal of the American College of Cardiology, , May-22, Volume: 49, Issue:20, 2007

Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 26, Issue:12, 2006

[Lisinopril-induced changes in antioxidant defense in patients with acute coronary syndrome and concomitant diabetes mellitus type 2].
Terapevticheskii arkhiv, , Volume: 77, Issue:12, 2005

[Antioxidative defense in patients with acute coronary syndrome and concomitant type 2 diabetes and its modification by lisinopril].
Kardiologiia, , Volume: 45, Issue:8, 2005

Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism.
Diabetes, , Volume: 52, Issue:9, 2003

Cholesterol feeding exacerbates myocardial injury in Zucker diabetic fatty rats.
American journal of physiology. Heart and circulatory physiology, , Volume: 278, Issue:1, 2000

Effect of granulocyte-colony stimulating factor on generation of oxygen-derived free radicals and myeloperoxidase activity in neutrophils from poorly controlled NIDDM patients.
Diabetes, , Volume: 46, Issue:1, 1997

Impairment of the oxygen-dependent microbicidal mechanisms of polymorphonuclear neutrophils in patients with type 2 diabetes is not associated with increased susceptibility to infection.
Diabetes research and clinical practice, , Volume: 19, Issue:3, 1993

MPO activity and generation of active O2 species in leukocytes from poorly controlled diabetic patients.
Diabetes care, , Volume: 15, Issue:8, 1992

[Myeloperoxidase activity and glycogen levels in peripheral blood neutrophils in patients with well controlled diabetes mellitus type 1 and 2].
Polski tygodnik lekarski (Warsaw, Poland : 1960), , Mar-07, Volume: 43, Issue:10, 1988

Antimyeloperoxidase antibody is a biomarker for progression of diabetic retinopathy.
Journal of diabetes and its complications, , Volume: 30, Issue:4

[Increased myelopepoxidase activity is a risk factor for ishemic heart disease in patients with diabetes mellitus].
Biomeditsinskaia khimiia, , Volume: 58, Issue:4

Expression of neutrophil elastase and myeloperoxidase mRNA in patients with newly diagnosed type 2 diabetes mellitus.
Diabetes & metabolic syndrome, , Volume: 14, Issue:2

Zucker diabetic fatty rat: a new model of impaired cutaneous wound repair with type II diabetes mellitus and obesity.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , Volume: 19, Issue:4

MPO-ANCA-associated pulmonary-renal vasculitis in a patient with diabetes mellitus.
Journal of nephrology, , Volume: 15, Issue:6

Changes in superoxide dismutase activities and concentrations and myeloperoxidase activities in leukocytes from patients with diabetes mellitus.
Journal of diabetes and its complications, , Volume: 13, Issue:5-6

H2S donors attenuate diabetic nephropathy in rats: Modulation of oxidant status and polyol pathway.
Pharmacological reports : PR, , Volume: 67, Issue:1, 2015

Predictive value of serum myeloperoxidase activity for thrombosis of arteriovenous fistulas.
Hemodialysis international. International Symposium on Home Hemodialysis, , Volume: 18, Issue:3, 2014

Association of myeloperoxidase G-463A gene polymorphism with diabetic nephropathy in Japanese type 2 diabetic subjects.
Endocrine journal, , Volume: 60, Issue:4, 2013

Is myeloperoxidase a key component in the ROS-induced vascular damage related to nephropathy in type 2 diabetes?
Antioxidants & redox signaling, , Nov-01, Volume: 19, Issue:13, 2013

Inability of legumes to reverse diabetic-induced nephropathy in rats despite improvement in blood glucose and antioxidant status.
Journal of medicinal food, , Volume: 13, Issue:1, 2010

Statin treatment and diabetes affect myeloperoxidase activity in maintenance hemodialysis patients.
Clinical journal of the American Society of Nephrology : CJASN, , Volume: 1, Issue:2, 2006

Mesangial accumulation of GA-pyridine, a novel glycolaldehyde-derived AGE, in human renal disease.
Kidney international, , Volume: 68, Issue:2, 2005

Genetic determination of TNF and myeloperoxidase production in dialyzed patients with diabetic nephropathy.
Renal failure, , Volume: 26, Issue:6, 2004

A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients.
Kidney international. Supplement, , Issue:84, 2003

Myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis superimposed on biopsy-proven diabetic nephrosclerosis.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 39, Issue:1, 2002

Simultaneous occurrence of diabetic glomerulosclerosis, IgA nephropathy, crescentic glomerulonephritis, and myeloperoxidase-antineutrophil cytoplasmic antibody seropositivity in a Chinese patient.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 40, Issue:4, 2002

Early manifestations of nephropathy in alloxan-treated rats.
Renal failure, , Volume: 20, Issue:4, 1998

Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats.
Indian journal of pharmacology, , Volume: 46, Issue:6

Association of serum levels of anti-myeloperoxidase antibody with retinal photoreceptor ellipsoid zone disruption in diabetic retinopathy.
Journal of diabetes and its complications, , Volume: 31, Issue:5, 2017

Possible involvement of NETosis in inflammatory processes in the eye: Evidence from a small cohort of patients.
Molecular vision, , Volume: 23, 2017

[The mediation of HIF-1α siRNA to the leukocyte adhesion and myeloid cell's activity in rat's retina under early stage of diabetic retinopathy].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology, , Volume: 51, Issue:5, 2015

Indicators of oxidative tissue damage and inflammatory activity in epiretinal membranes of proliferative diabetic retinopathy, proliferative vitreoretinopathy and macular pucker.
German journal of ophthalmology, , Volume: 4, Issue:1, 1995

Increased lipid peroxide levels and myeloperoxidase activity in the vitreous of patients suffering from proliferative diabetic retinopathy.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, , Volume: 231, Issue:11, 1993

Antimyeloperoxidase antibody is a biomarker for progression of diabetic retinopathy.
Journal of diabetes and its complications, , Volume: 30, Issue:4

Pulmonary and Intestinal Involvement in a Patient with Myeloperoxidase-specific Antineutrophil Cytoplasmic Antibody-positive Hermansky-Pudlak Syndrome.
Internal medicine (Tokyo, Japan), , Jan-01, Volume: 62, Issue:1, 2023

Wumei pills attenuates 5-fluorouracil-induced intestinal mucositis through Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB pathway and microbiota regulation.
World journal of gastroenterology, , Aug-28, Volume: 28, Issue:32, 2022

An assessment of potential biomarkers of environment enteropathy and its association with age and microbial infections among children in Bangladesh.
PloS one, , Volume: 16, Issue:4, 2021

Impact of Different Strategies for Delivering Supplemental Zinc on Selected Fecal Markers of Environmental Enteric Dysfunction among Young Laotian Children: A Randomized Controlled Trial.
The American journal of tropical medicine and hygiene, , Volume: 103, Issue:4, 2020

Role of regulatory T cells in irinotecan-induced intestinal mucositis.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, , Mar-30, Volume: 115, 2018

NOX1/NADPH Oxidase Expressed in Colonic Macrophages Contributes to the Pathogenesis of Colonic Inflammation in Trinitrobenzene Sulfonic Acid-Induced Murine Colitis.
The Journal of pharmacology and experimental therapeutics, , Volume: 360, Issue:1, 2017

Lafutidine, a histamine H2 receptor antagonist with mucosal protective properties, attenuates 5-fluorouracil-induced intestinal mucositis in mice through activation of extrinsic primary afferent neurons.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, , Volume: 68, Issue:1, 2017

An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice.
The Journal of pharmacology and experimental therapeutics, , Volume: 360, Issue:1, 2017

A new animal model of intestinal mucositis induced by the combination of irinotecan and 5-fluorouracil in mice.
Cancer chemotherapy and pharmacology, , Volume: 77, Issue:2, 2016

Oat β-glucan ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice.
Food & function, , Volume: 6, Issue:11, 2015

The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis.
PloS one, , Volume: 10, Issue:10, 2015

Neutrophil recruitment is critical for 5-fluorouracil-induced diarrhea and the decrease in aquaporins in the colon.
Pharmacological research, , Volume: 87, 2014

Efficacy of Bifidobacterium breve NCC2950 against DSS-induced colitis is dependent on bacterial preparation and timing of administration.
Beneficial microbes, , Volume: 5, Issue:1, 2014

Saccharomyces boulardii ameliorates clarithromycin- and methotrexate-induced intestinal and hepatic injury in rats.
The British journal of nutrition, , Aug-28, Volume: 110, Issue:3, 2013

Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants.
The American journal of tropical medicine and hygiene, , Volume: 88, Issue:2, 2013

Antidiarrheal and intestinal antiinflammatory activities of a methanolic extract of Qualea parviflora Mart. in experimental models.
Journal of ethnopharmacology, , Dec-12, Volume: 150, Issue:3, 2013

Hymenaea stigonocarpa Mart. ex Hayne: a Brazilian medicinal plant with gastric and duodenal anti-ulcer and antidiarrheal effects in experimental rodent models.
Journal of ethnopharmacology, , Aug-30, Volume: 143, Issue:1, 2012

Dietary intervention with narrow-leaved cattail rhizome flour (Typha angustifolia L.) prevents intestinal inflammation in the trinitrobenzenesulphonic acid model of rat colitis.
BMC complementary and alternative medicine, , May-04, Volume: 12, 2012

Anti-inflammatory effects of methanol extract of Patrinia scabiosaefolia in mice with ulcerative colitis.
Journal of ethnopharmacology, , Jul-14, Volume: 136, Issue:3, 2011

Impact of disrupting adenosine A₃ receptors (A₃⁻/⁻ AR) on colonic motility or progression of colitis in the mouse.
Inflammatory bowel diseases, , Volume: 17, Issue:8, 2011

Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents.
Journal of medicinal chemistry, , Oct-28, Volume: 53, Issue:20, 2010

Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 299, Issue:1, 2010

Attenuation of experimental murine colitis by acanthoic acid from Acanthopanax koreanum.
Archives of pharmacal research, , Volume: 33, Issue:1, 2010

Si-Ni-San, a traditional Chinese prescription, and its active ingredient glycyrrhizin ameliorate experimental colitis through regulating cytokine balance.
International immunopharmacology, , Volume: 9, Issue:12, 2009

Partially hydrolyzed guar gum attenuates the severity of pouchitis in a rat model of ileal J pouch-anal anastomosis.
Digestive diseases and sciences, , Volume: 54, Issue:3, 2009

Intestinal barrier function in response to abundant or depleted mucosal glutathione in Salmonella-infected rats.
BMC physiology, , Apr-17, Volume: 9, 2009

Therapeutic effect of kakkonto in a mouse model of food allergy with gastrointestinal symptoms.
International archives of allergy and immunology, , Volume: 148, Issue:3, 2009

The possible mechanisms of Fructus Mume pill in the treatment of colitis induced by 2,4,6-trinitrobenzene sulfonic acid in rats.
Journal of ethnopharmacology, , Dec-10, Volume: 126, Issue:3, 2009

Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis.
Sleep medicine, , Volume: 10, Issue:6, 2009

Role of cytokines (TNF-alpha, IL-1beta and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: effect of pentoxifylline and thalidomide.
Cancer chemotherapy and pharmacology, , Volume: 61, Issue:5, 2008

Intestinal anti-inflammatory activity of coumarin and 4-hydroxycoumarin in the trinitrobenzenesulphonic acid model of rat colitis.
Biological & pharmaceutical bulletin, , Volume: 31, Issue:7, 2008

In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027.
European journal of pharmacology, , May-31, Volume: 586, Issue:1-3, 2008

The beneficial effect of Rheum tanguticum polysaccharide on protecting against diarrhea, colonic inflammation and ulceration in rats with TNBS-induced colitis: the role of macrophage mannose receptor in inflammation and immune response.
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A case of pulmonary arteritis with stenosis of the main pulmonary arteries with positive myeloperoxidase-antineutrophil cytoplasmic autoantibodies.
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Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by geniposide.
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Serum advanced oxidation protein products, myeloperoxidase and ascorbic acid in pre-eclampsia and eclampsia.
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The Role of Oxidative Stress in the Clinical Manifestations of Childhood Asthma.
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Lymphatic diversion prevents myocardial edema following mesenteric ischemia/reperfusion.
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Ultrasonication and thermosonication blanching treatments of carrot at varying frequencies: Effects on peroxidase inactivation mechanisms and quality characterization evaluation.
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Pre-harvest spray of GABA and spermine delays postharvest senescence and alleviates chilling injury of gerbera cut flowers during cold storage.
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Effects of radio-frequency energy on peroxidase inactivation and physiochemical properties of stem lettuce and the underlying cell-morphology mechanism.
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Influence of exogenously applied nitric oxide on strawberry (Fragaria × ananassa) plants grown under iron deficiency and/or saline stress.
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Self-Assembly and Compartmentalization of Nanozymes in Mesoporous Silica-Based Nanoreactors.
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The effect of mealybug Pseudococcus longispinus (Targioni Tozzetti) infestation of different density on physiological responses of Phalaenopsis × hybridum 'Innocence'.
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Populus from high altitude has more efficient protective mechanisms under water stress than from low-altitude habitats: a study in greenhouse for cuttings.
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Transgenic tobacco plants accumulating osmolytes show reduced oxidative damage under freezing stress.
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Inhibition of enteral enzymes by enteroclysis with nafamostat mesilate reduces neutrophil activation and transfusion requirements after hemorrhagic shock.
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Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury.
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MRI of Iron Oxide Nanoparticles and Myeloperoxidase Activity Links Inflammation to Brain Edema in Experimental Cerebral Malaria.
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Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.
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Ulinastatin attenuates oxidation, inflammation and neural apoptosis in the cerebral cortex of adult rats with ventricular fibrillation after cardiopulmonary resuscitation.
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Immune following suppression mesenchymal stem cell transplantation in the ischemic brain is mediated by TGF-β.
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Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury.
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The clinical pattern differentiates ANCA-positive infective endocarditis patients from ANCA-associated vasculitis patients: a 23 years' retrospective cohort study in China and follow-ups.
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Identification of local angiogenic and inflammatory markers in the menstrual blood of women with endometriosis.
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Inflammatory markers in endometriosis: reduced peritoneal neutrophil response in minimal endometriosis.
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Protective effects of polydatin on LPS-induced endometritis in mice.
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Associations of periparturient plasma biochemical parameters, endometrial leukocyte esterase and myeloperoxidase, and bacterial detection with clinical and subclinical endometritis in postpartum dairy cows.
The Journal of veterinary medical science, , Feb-20, Volume: 80, Issue:2, 2018

Eucalyptus robusta leaves methanolic extract suppresses inflammatory mediators by specifically targeting TLR4/TLR9, MPO, COX2, iNOS and inflammatory cytokines in experimentally-induced endometritis in rats.
Journal of ethnopharmacology, , Mar-01, Volume: 213, 2018

IFN-τ Plays an Anti-Inflammatory Role in Staphylococcus aureus-Induced Endometritis in Mice Through the Suppression of NF-κB Pathway and MMP9 Expression.
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Berberine hydrochloride attenuates lipopolysaccharide-induced endometritis in mice by suppressing activation of NF-κB signal pathway.
International immunopharmacology, , Volume: 24, Issue:1, 2015

High concentrations of myeloperoxidase in the equine uterus as an indicator of endometritis.
Theriogenology, , Apr-15, Volume: 81, Issue:7, 2014

Neutrophil extracellular traps formation by bacteria causing endometritis in the mare.
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Antenatal betamethasone attenuates intrauterine infection-aggravated hyperoxia-induced lung injury in neonatal rats.
Pediatric research, , Volume: 73, Issue:6, 2013

Selective CB2 up-regulation in women affected by endometrial inflammation.
Journal of cellular and molecular medicine, , Volume: 12, Issue:2, 2008

Experimental endometriosis in the rat is correlated with colonic motor function alterations but not with bacterial load.
Reproductive sciences (Thousand Oaks, Calif.), , Volume: 14, Issue:8, 2007

Neutrophil function and energy status in Holstein cows with uterine health disorders.
Veterinary immunology and immunopathology, , Sep-15, Volume: 113, Issue:1-2, 2006

A prebiotic effect of Ecklonia cava on the growth and mortality of olive flounder infected with pathogenic bacteria.
Fish & shellfish immunology, , Volume: 51, 2016

Identification of a myeloperoxidase-like ortholog from rock bream (Oplegnathus fasciatus), deciphering its transcriptional responses to induced pathogen stress.
Fish & shellfish immunology, , Volume: 45, Issue:2, 2015

Effect of Edwardsiella tarda immunization on systemic immune response, mucosal immune response and protection in catla (Catla catla).
Veterinary research communications, , Volume: 38, Issue:2, 2014

Intestinal epithelial CD98 directly modulates the innate host response to enteric bacterial pathogens.
Infection and immunity, , Volume: 81, Issue:3, 2013

Changes of serum myeloperoxidase and nitric oxide in the early stage of Edwardsiella ictaluri infection in channel catfish, Ictalurus punctatus (Rafinesque).
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Distinct compartmentalization of NF-κB activity in crypt and crypt-denuded lamina propria precedes and accompanies hyperplasia and/or colitis following bacterial infection.
Infection and immunity, , Volume: 80, Issue:2, 2012

Modulation of hepatic cytochrome P450s by Citrobacter rodentium infection in interleukin-6- and interferon-{gamma}-null mice.
The Journal of pharmacology and experimental therapeutics, , Volume: 335, Issue:2, 2010

Saccharomyces boulardii ameliorates Citrobacter rodentium-induced colitis through actions on bacterial virulence factors.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 294, Issue:1, 2008

Crucial role of the melanocortin receptor MC1R in experimental colitis.
Gut, , Volume: 55, Issue:10, 2006

Citrobacter rodentium infection causes iNOS-independent intestinal epithelial dysfunction in mice.
Canadian journal of physiology and pharmacology, , Volume: 84, Issue:12, 2006

Positive bacterial culture of semen from infertile men with asymptomatic leukocytospermia.
International journal of fertility and women's medicine, , Volume: 47, Issue:6

A mineral extract from red algae ameliorates chronic spontaneous colitis in IL-10 deficient mice in a mouse strain dependent manner.
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Intestinal upregulation of melanin-concentrating hormone in TNBS-induced enterocolitis in adult zebrafish.
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Low endogenous prostaglandin E2 predisposes to relapsing inflammation in experimental rat enterocolitis.
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The effects of Lactobacillus strains and oat fiber on methotrexate-induced enterocolitis in rats.
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Pectin-supplemented enteral diet reduces the severity of methotrexate induced enterocolitis in rats.
Scandinavian journal of gastroenterology, , Volume: 31, Issue:6, 1996

The role of local and systemic cytokines in patients infected with Clostridium difficile.
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Effect of Lactobacillus acidophilus & epidermal growth factor on experimentally induced Clostridium difficile infection.
The Indian journal of medical research, , Volume: 133, 2011

Effect of biotherapeutics on cyclosporin-induced Clostridium difficile infection in mice.
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Comparative role of antibiotic and proton pump inhibitor in experimental Clostridium difficile infection in mice.
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Essential involvement of IFN-gamma in Clostridium difficile toxin A-induced enteritis.
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Extrinsic surgical denervation inhibits Clostridium difficile toxin A-induced enteritis in rats.
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Mucosal permeability after subclinical intestinal ischemia-reperfusion injury: an exploration of possible mechanisms.
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Inflammatory enzyme composition of the neonatal rat intestine: implications for susceptibility to ischemia.
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Endogenous nitric oxide protects against platelet-activating factor-induced bowel injury in the rat.
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Inactivation of Clostridium difficile cytotoxin by the neutrophil myeloperoxidase system.
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Torasemide-induced Vascular Purpura in the Course of Eosinophilic Granulomatosis with Polyangiitis.
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Recognizing Central Nervous System Involvement as a Progressive Feature of Microscopic Polyangiitis: A Diagnostic Dilemma.
The American journal of medicine, , Volume: 132, Issue:9, 2019

Case 32-2017. A 64-Year-Old Man with Dyspnea, Wheezing, Headache, Cough, and Night Sweats.
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Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis.
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Clinicopathological and immunohistochemical analysis of 19 cases of oral eosinophilic ulcers.
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Effects of exposure to nanoparticle-rich or -depleted diesel exhaust on allergic pathophysiology in the murine lung.
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Systemic vasculitis in a patient with atopic dermatitis, eosinophilia, pulmonary-renal syndrome, and positive myeloperoxidase antibody: a classification conundrum.
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Eosinophil degranulation is more important than eosinophilia in identifying asthma in chronic cough.
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Eosinophilic venulitis of colon presenting as ileocecal mass.
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Arginase activity differs with allergen in the effector phase of ovalbumin- versus trimellitic anhydride-induced asthma.
Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 88, Issue:2, 2005

Eosinophilic airway inflammation as an underlying mechanism of undiagnosed prolonged cough in primary healthcare patients.
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Cytochemical demonstration of methanol-resistant peroxidase in eosinophils using a combined method of wright stain and benzidine base.
International journal of hematology, , Volume: 76, Issue:4, 2002

Eosinophilia in duck embryos induced by an apathogenic strain of duck enteritis virus.
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A new murine model of pulmonary eosinophilic hypersensitivity: contribution to experimental asthma.
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Role of particulate antigens of Aspergillus in murine eosinophilia.
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Eosinophil peroxidase deficiency in New Zealand white mice.
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Influence of endogenous cortisol on eosinophil function in sensitized pigs: direct measurements of eosinophil peroxidase.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 26, Issue:4, 1996

BAL neutrophilia in asthmatic patients. A by-product of eosinophil recruitment?
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Serum levels of eosinophil cationic protein, eosinophil-derived neurotoxin and myeloperoxidase in infections with filariae and schistosomes.
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Blood eosinophil number and activity in relation to lung function in patients with asthma and with eosinophilia.
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Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) and peroxidase in macrophages, eosinophils, and extracellular matrix of the skin in the hypereosinophilic syndrome.
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Experimental eosinophilia and inflammation--the effect of various inflammatory mediators and chemoattractants.
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Purification of eosinophil peroxidase and studies of biosynthesis and processing in human marrow cells.
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Some enzymatic characteristics of eosinophil peroxidase from patients with eosinophilia and from healthy donors.
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Arginine-rich cationic proteins of human eosinophil granules: comparison of the constituents of eosinophilic and neutrophilic leukocytes.
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The protective effect of vitamin U on pentylenetetrazole-induced brain damage in rats.
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Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis.
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Co-administration of acetyl-11-keto-beta-boswellic acid, a specific 5-lipoxygenase inhibitor, potentiates the protective effect of COX-2 inhibitors in kainic acid-induced neurotoxicity in mice.
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Activation of the phagocyte NADPH oxidase/NOX2 and myeloperoxidase in the mouse brain during pilocarpine-induced temporal lobe epilepsy and inhibition by ketamine.
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First reported case of ANCA-associated vasculitis induced by oxaliplatin, capecitabine, and trastuzumab.
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The complexity of classifying ANCA-associated small-vessel vasculitis in actual clinical practice: data from a multicenter retrospective survey.
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Pathways of Neutrophil Granulocyte Activation in Hereditary Angioedema with C1 Inhibitor Deficiency.
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Anti-inflammatory protein tumor necrosis factor-α-stimulated protein 6 (TSG-6) promotes early gingival wound healing: an in vivo study.
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Leukemia cutis: case report and review of literature.
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Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase.
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Identification and characterization of the human myeloperoxidase promoter.
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Inhibition of the differentiation of human myeloid cell lines by redox changes induced through glutathione depletion.
The Biochemical journal, , Aug-01, Volume: 301 ( Pt 3), 1994

Establishment of a new cell line with the characteristics of a multipotential progenitor from a patient with chronic myelogenous leukemia in early erythroblastic crisis.
Leukemia, , Volume: 8, Issue:1, 1994

The monocytic cell line SKM-1 strongly expresses the myeloperoxidase gene.
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Identification of circulating micromegakaryocytes in a case of erythroleukemia.
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Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
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Depressed neutrophil-mediated tumor cell cytotoxicity in subjects affected by hereditary myeloperoxidase deficiency and secondary neoplasia.
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The possible neurobehavioral protective effects of natural antioxidant against phototoxicity attenuation of antimicrobial quinolone group in rats.
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Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection.
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Mesenteric lymph duct drainage attenuates acute lung injury in rats with severe intraperitoneal infection.
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A novel strategy for antimicrobial agent: role of exogenous carbon monoxide on suppressing Escherichia coli vitality and toxicity.
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Intravesical hyaluronic acid treatment improves bacterial cystitis and reduces cystitis-induced hypercontractility in rats.
International journal of urology : official journal of the Japanese Urological Association, , Volume: 22, Issue:6, 2015

Intravenous infusion of mesenteric lymph from severe intraperitoneal infection rats causes lung injury in healthy rats.
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New markers: urine xanthine oxidase and myeloperoxidase in the early detection of urinary tract infection.
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Exogenous carbon monoxide suppresses Escherichia coli vitality and improves survival in an Escherichia coli-induced murine sepsis model.
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Antenatal betamethasone attenuates intrauterine infection-aggravated hyperoxia-induced lung injury in neonatal rats.
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Evaluation of the effects of ozone therapy on Escherichia coli-induced cytitis in rat.
Irish journal of medical science, , Volume: 182, Issue:4, 2013

Anti-LAMP-2 antibodies are not prevalent in patients with antineutrophil cytoplasmic autoantibody glomerulonephritis.
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Alcohol impairs the myeloid proliferative response to bacteremia in mice by inhibiting the stem cell antigen-1/ERK pathway.
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Gut flora enhance bacterial clearance in lung through toll-like receptors 4.
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Repeated systemic Escherichia coli infection enhances anti-oxidant response in hypercholesterolemic mice inducing cardiovascular inflammation.
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Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice.
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Modulation of host innate immune response in the bladder by uropathogenic Escherichia coli.
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LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression.
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Effect of leukotoxin of Mannheimia haemolytica and LPS of E. coli on secretory response of bovine neutrophils in vitro.
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Different effects of surfactant and inhaled nitric oxide in modulation of inflammatory injury in ventilated piglet lungs.
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Urinary tract infection in iNOS-deficient mice with focus on bacterial sensitivity to nitric oxide.
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Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia.
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Platelet-activating factor and bacteremia-induced pulmonary hypertension.
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Concomitant increase in neutrophil adhesion to inflammatory peritoneum and remote organs during peritonitis.
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Partial liquid ventilation reduces pulmonary neutrophil accumulation in an experimental model of systemic endotoxemia and acute lung injury.
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Influence of antimicrobial agents on bactericidal activity of bovine milk polymorphonuclear leukocytes.
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KatP, a novel catalase-peroxidase encoded by the large plasmid of enterohaemorrhagic Escherichia coli O157:H7.
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Granulocyte colony-stimulating factor prevents ethanol-induced impairment in host defense in septic rats.
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A novel leukotriene B4-receptor antagonist in endotoxin shock: a prospective, controlled trial in a porcine model.
Critical care medicine, , Volume: 21, Issue:12, 1993

Effect of granulocyte colony-stimulating factor on sepsis-induced changes in neutrophil accumulation and organ glucose uptake.
The Journal of infectious diseases, , Volume: 166, Issue:2, 1992

Sepsis- and endotoxin-induced increase in organ glucose uptake in leukocyte-depleted rats.
The American journal of physiology, , Volume: 263, Issue:6 Pt 2, 1992

Induction of Escherichia coli mastitis in cows fed selenium-deficient or selenium-supplemented diets.
American journal of veterinary research, , Volume: 50, Issue:12, 1989

Role of complement-derived and bacterial formylpeptide chemotactic factors in the in vivo migration of neutrophils in experimental Escherichia coli pyelonephritis in rats.
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Neutrophil function in a rat model of endotoxin-induced lung injury.
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The differences in myeloperoxidase activity and consumption of thyroid hormones by bactericidal systems in guinea pigs with peritoneal contamination.
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Intestinal and systemic inflammation induced by symptomatic and asymptomatic enterotoxigenic
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Some of the effective factors in the pathogenesis of gastro-oesophageal reflux disease.
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Tracking significant modules and key genes for esophageal squamous cell carcinoma based on differential modules.
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Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma.
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Evaluation of a 4-protein serum biomarker panel-biglycan, annexin-A6, myeloperoxidase, and protein S100-A9 (B-AMP)-for the detection of esophageal adenocarcinoma.
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Ultra-small particles of iron oxide as peroxidase for immunohistochemical detection.
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Association of the polymorphisms of MTHFR C677T, VDR C352T, and MPO G463A with risk for esophageal squamous cell dysplasia and carcinoma.
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Simultaneous progression of oxidative stress and angiogenesis in malignant transformation of Barrett esophagus.
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Oxidative stress has a role in malignant transformation in Barrett's oesophagus.
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Possible risk reduction in esophageal cancer associated with MPO -463 A allele.
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Impaired neutrophil bactericidal activity correlates with the infection occurring after surgery for esophageal cancer.
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Lethal candida sepsis associated with myeloperoxidase deficiency and pre-eclampsia.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
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Paediatric-onset generalized pustular psoriasis secondary to myeloperoxidase mutations.
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Pantoprazole and perinuclear antineutrophil cytoplasmic antibody-associated vasculitis.
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Treatment for chemical burning using liquid crystalline nanoparticles as an ophthalmic delivery system for pirfenidone.
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Characteristics of polymorphonuclear leukocyte infiltration into the alkali burned eye and the influence of sodium citrate.
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The complexity of classifying ANCA-associated small-vessel vasculitis in actual clinical practice: data from a multicenter retrospective survey.
Rheumatology international, , Volume: 40, Issue:2, 2020

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'Turning the right screw': targeting the interleukin-6 receptor to reduce unfavourable tissue remodelling after myocardial infarction.
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A Ruptured Jejunal Arterial Aneurysm in a Young Woman Undergoing Chronic Hemodialysis Due to Myeloperoxidase-antineutrophil Cytoplasmic Antibody-associated Vasculitis.
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The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitis.
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Neutrophil Activation in Acute Hemorrhagic Fever With Renal Syndrome Is Mediated by Hantavirus-Infected Microvascular Endothelial Cells.
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Diffuse alveolar haemorrhage associated with subsequent development of ANCA positivity and emphysema in three young adults.
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Chronic alveolar haemorrhage in a paediatric patient: a diagnostic and treatment challenge.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
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Nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytes.
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Titre and affinity of propylthiouracil-induced anti-myeloperoxidase antibodies are closely associated with the development of clinical vasculitis.
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Hypothyroidism and antithyroglobulin and antithyroperoxidase antibodies in the pathogenesis of autoimmune associated congenital heart block.
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Nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytes.
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Effect of Continuous B Cell Depletion With Rituximab on Pathogenic Autoantibodies and Total IgG Levels in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
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Novel association between sperm reactive oxygen species production, sperm morphological defects, and the sperm deformity index.
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Protective effect of ascorbic acid on cyclophosphamide- induced testicular gametogenic and androgenic disorders in male rats.
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Why do we continue to determine alpha-glucosidase in human semen?
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Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation.
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A comparison of the sperm mixed-agglutination reaction test with the peroxidase-labelled protein A test for detecting antisperm antibodies in infertile men with varicocele.
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Positive myeloperoxidase staining (Endtz test) as an indicator of excessive reactive oxygen species formation in semen.
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Influenza Virus Infection Increases Host Susceptibility To Secondary Infection with Pseudomonas aeruginosa, and This Is Attributed To Neutrophil Dysfunction through Reduced Myeloperoxidase Activity.
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Circulating Rather Than Alveolar Extracellular Deoxyribonucleic Acid Levels Predict Outcomes in Influenza.
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High Level of Neutrophil Extracellular Traps Correlates With Poor Prognosis of Severe Influenza A Infection.
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Enhanced catalytic activity of gold nanoparticle-carbon nanotube hybrids for influenza virus detection.
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Leucomycin A3, a 16-membered macrolide antibiotic, inhibits influenza A virus infection and disease progression.
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Key role of regulated upon activation normal T-cell expressed and secreted, nonstructural protein1 and myeloperoxidase in cytokine storm induced by influenza virus PR-8 (A/H1N1) infection in A549 bronchial epithelial cells.
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Interleukin 12 and myeloperoxidase (MPO) in Vietnamese children with acute respiratory distress syndrome due to Avian influenza (H5N1) infection.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
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Inhibiting myeloperoxidase prevents onset and reverses established high-fat diet-induced microvascular insulin resistance.
American journal of physiology. Endocrinology and metabolism, , 12-01, Volume: 317, Issue:6, 2019

Myeloperoxidase as cardiovascular risk marker in pre-pubertal preterm children?
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Cardiovascular risk biomarkers and metabolically unhealthy status in prepubertal children: Comparison of definitions.
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PAI-1 levels are related to insulin resistance and carotid atherosclerosis in subjects with familial combined hyperlipidemia.
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Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects.
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Effect of Low- Versus High-Intensity Exercise Training on Biomarkers of Inflammation and Endothelial Dysfunction in Adolescents With Obesity: A 6-Month Randomized Exercise Intervention Study.
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Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats.
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Insulin Resistance in PCOS Patients Enhances Oxidative Stress and Leukocyte Adhesion: Role of Myeloperoxidase.
PloS one, , Volume: 11, Issue:3, 2016

Association of myeloperoxidase levels with cardiometabolic factors and renal function in prepubertal children.
European journal of clinical investigation, , Volume: 46, Issue:1, 2016

Hypochlorous acid via peroxynitrite activates protein kinase Cθ and insulin resistance in adipocytes.
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Trace elements profile is associated with insulin resistance syndrome and oxidative damage in thyroid disorders: Manganese and selenium interest in Algerian participants with dysthyroidism.
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The association of autoimmune thyroiditis and non-functional adrenal incidentalomas with insulin resistance.
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Oxidized HDL and LDL in adolescents with type 2 diabetes compared to normal weight and obese peers.
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Novel CoQ10 antidiabetic mechanisms underlie its positive effect: modulation of insulin and adiponectine receptors, Tyrosine kinase, PI3K, glucose transporters, sRAGE and visfatin in insulin resistant/diabetic rats.
PloS one, , Volume: 9, Issue:2, 2014

Myeloperoxidase: a therapeutic target for preventing insulin resistance and the metabolic sequelae of obesity?
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Antioxidant profile of salivary glands in high fat diet-induced insulin resistance rats.
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Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance.
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Moderate-intensity aerobic training program improves insulin sensitivity and inflammatory markers in a pilot study of morbidly obese minority teens.
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Serum Fetuin-A levels, insulin resistance and oxidative stress in women with polycystic ovary syndrome.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, , Volume: 29, Issue:12, 2013

Circulating adhesion molecules, matrix metalloproteinase-9, plasminogen activator inhibitor-1, and myeloperoxidase in coronary artery disease patients with stable and unstable angina.
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Myeloperoxidases and polycystic ovary syndrome.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, , Volume: 28, Issue:1, 2012

Effect of long- and short-term treatments with pravastatin on diabetes mellitus and pancreatic fibrosis in the Otsuka-Long-Evans-Tokushima fatty rat.
British journal of pharmacology, , Jan-01, Volume: 159, Issue:2, 2010

Effect of PPAR-gamma agonist treatment on markers of endothelial dysfunction in patients with type 2 diabetes mellitus.
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Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism.
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Fructose-fed rats are protected against ischemia/reperfusion injury.
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Antioxidants attenuate oxidative damage in rat skeletal muscle during mild ischaemia.
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Xanthine oxidase and activated neutrophils cause oxidative damage to skeletal muscle after contractile claudication.
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Association of polymorphisms in myeloperoxidase and catalase genes with precancerous changes in the gastric mucosa of patients at inner-city hospitals in New York.
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The use of delta neutrophil index and myeloperoxidase index as diagnostic predictors of strangulated mechanical bowel obstruction in the emergency department.
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Myeloperoxidase assay in plasma and peritoneal fluid of horses with gastrointestinal disease.
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Local and remote lesions in horses subjected to small colon distension and decompression.
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Morphological and electrophysiological changes in mouse dorsal root ganglia after partial colonic obstruction.
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Development of an enzyme-linked immunosorbent assay for specific equine neutrophil myeloperoxidase measurement in blood.
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Experimental colonic obstruction increases collagen degradation by matrix metalloproteinases in the bowel wall.
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Inhaled carbon monoxide suppresses the development of postoperative ileus in the murine small intestine.
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Plasma myeloperoxidase level and polymorphonuclear leukocyte activation in horses suffering from large intestinal obstruction requiring surgery: preliminary results.
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The characteristics of intestinal injury peripheral to strangulating obstruction lesions in the equine small intestine.
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Equine neutrophil myeloperoxidase in plasma: design of a radio-immunoassay and first results in septic pathologies.
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Bacterial load and inflammatory reaction in the bowel wall after colonic obstruction. An experimental study in rats.
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Ascorbic acid inhibits the activity of polymorphonuclear leukocytes in inflamed ocular tissues.
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Quantification of ocular inflammation: evaluation of polymorphonuclear leucocyte infiltration by measuring myeloperoxidase activity.
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Acetaminophen elevates unbound bilirubin levels by the glucose oxidase-peroxidase method.
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Relationship between arthroscopic joint evaluation and the levels of Coll2-1, Coll2-1NO(2), and myeloperoxidase in the blood and synovial fluid of horses affected with osteochondrosis of the tarsocrural joint.
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Coll2-1, Coll2-1NO2 and myeloperoxidase concentrations in the synovial fluid of equine tarsocrural joints affected with osteochondrosis.
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Measurement of equine myeloperoxidase (MPO) activity in synovial fluid by a modified MPO assay and evaluation of joint diseases - an initial case study.
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Antineutrophil cytoplasmic antibodies in synovial fluid and in serum of patients with rheumatoid arthritis and other types of synovitis.
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Morphologic, quantitative and cytoenzymologic studies of synoviocytic and monocytic cells in synovial fluid.
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Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase.
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Photoisomers: obfuscating factors in clinical peroxidase measurements of unbound bilirubin?
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Unusual malignant cells in urine.
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The activity of neutrophil myeloperoxidase in patients with renal cancer before and after embolization.
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Local and metastatic growth and in vivo differentiation of human myeloid leukemia cells transplanted in nude mice.
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Nonleukemic granulocytic sarcoma of kidney with mixed phenotype blasts: a diagnostic dilemma.
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Effect of diabetes mellitus on acinar morphology, peroxidase concentration, and release in isolated rat lacrimal glands.
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Reactive oxygen species production by blood neutrophils of patients with laryngeal carcinoma and antioxidative enzyme activity in their blood.
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Substantially reduced risk of cancer of the aerodigestive tract in subjects with variant--463A of the myeloperoxidase gene.
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Immunoelectron microscopical identification of the c-erbB-2 oncoprotein in patients with laryngeal squamous cell carcinoma.
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Enzymatic deficiencies of the immune system cells in patients with cancer of the larynx and other malignancies.
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Effect of radiotherapy on the neutrophil and the lymphocyte enzymatic equipment and serum immunoglobulins in patients with cancer of the larynx.
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Acta haematologica Polonica, , Volume: 12, Issue:1

Oxidative stress: a key regulator of leiomyoma cell survival.
Fertility and sterility, , Volume: 107, Issue:6, 2017

Insulin-like growth factors II exon 9 and E-cadherin-Pml I but not myeloperoxidase promoter-463, urokinase-ApaL I nor xeroderma pigmentosum polymorphisms are associated with higher susceptibility to leiomyoma.
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Enzymes of neutrophils in women with malignant tumors of reproductive organs.
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Mocetinostat combined with gemcitabine for the treatment of leiomyosarcoma: Preclinical correlates.
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Role of peroxynitrite in macrophage microbicidal mechanisms in vivo revealed by protein nitration and hydroxylation.
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[Morphological and cytochemical indices of the peripheral blood in mice with experimental cutaneous leishmaniasis].
Meditsinskaia parazitologiia i parazitarnye bolezni, , Issue:2

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Activity and turnover of eosinophil and neutrophil granulocytes are altered in visceral leishmaniasis.
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Detection of circulating antigens in sera from visceral leishmaniasis patients using dot-ELISA.
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NADH-oxidase, NADPH-oxidase and myeloperoxidase activity of visceral leishmaniasis patients.
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A role for oxygen-dependent mechanisms in killing of Leishmania donovani tissue forms by activated macrophages.
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Idiopathic histiocytoid Sweet syndrome: a case report with clinical and histopathological considerations.
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[Prospects for leprosy treatment via complexation of rifampicin witH iodide and horse-radish root].
Problemy tuberkuleza i boleznei legkikh, , Issue:4, 2007

Peroxidase in therapy of experimentally induced leprosy.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, , Volume: 69, Issue:1, 2001

Effect of peroxidase in complex with basic antileprosy drugs on liver, blood, and functional activity of phagocytes in mice with experimental leprosy.
Bulletin of experimental biology and medicine, , Volume: 132, Issue:5, 2001

Phagocytic myeloperoxidase in leprosy pathogenesis.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, , Volume: 68, Issue:1, 2000

Effect of peroxidase on the development of experimental leprosy in mice after intraplantar infection.
Bulletin of experimental biology and medicine, , Volume: 129, Issue:5, 2000

Effects of peroxidase therapy on functional state of the liver and phagocytes and blood cell counts in mice with experimental leprosy.
Bulletin of experimental biology and medicine, , Volume: 130, Issue:7, 2000

In vitro and in vivo effects of dapsone on neutrophil and lymphocyte functions in normal individuals and patients with lepromatous leprosy.
Antimicrobial agents and chemotherapy, , Volume: 19, Issue:4, 1981

Enzyme-linked immunoassay in the diagnosis of leptospirosis in domestic animals using peroxidase-conjugated protein-A.
Comparative immunology, microbiology and infectious diseases, , Volume: 6, Issue:1, 1983

Degradation of vincristine by myeloperoxidase and hypochlorous acid in children with acute lymphoblastic leukemia.
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Acute T-lymphoblastic leukemia relapsed with the character of myeloid/natural killer cell precursor phenotype: a case report.
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Detection of myeloperoxidase gene expression in minimally differentiated acute myelogenous leukemia (AML-M0) using in situ hybridization.
Diagnostic molecular pathology : the American journal of surgical pathology, part B, , Volume: 4, Issue:3, 1995

Lineage determination of CD7+ CD5- CD2- and CD7+ CD5+ CD2- lymphoblasts: studies on phenotype, genotype, and gene expression of myeloperoxidase, CD3 epsilon, and CD3 delta.
American journal of hematology, , Volume: 45, Issue:4, 1994

Myeloperoxidase: expression and modulation in a large panel of human leukemia-lymphoma cell lines.
Blood, , Sep-01, Volume: 82, Issue:5, 1993

Fast double antibody radioimmunoassay of human granulocyte myeloperoxidase and its application to plasma.
Journal of immunological methods, , Mar-21, Volume: 137, Issue:2, 1991

Childhood biphenotypic leukemia: detection of mixed lymphoid and myeloid populations in bone marrow specimens.
Human pathology, , Volume: 19, Issue:6, 1988

Myeloperoxidase gene expression in blast cells with a lymphoid phenotype in cases of acute lymphoblastic leukemia.
Blood, , Volume: 72, Issue:3, 1988

Characterization of myeloid leukemia by monoclonal antibodies, with an emphasis on antibodies against myeloperoxidase.
Acta haematologica, , Volume: 78 Suppl 1, 1987

Simultaneous evaluation of terminal deoxynucleotidyl transferase and myeloperoxidase in acute leukemias using an immunocytochemical method.
American journal of clinical pathology, , Volume: 87, Issue:6, 1987

'Pseudo-lymphoid' leukaemia with unusual features: ultrastructural, immunological, cytogenetic and molecular studies.
European journal of haematology, , Volume: 38, Issue:4, 1987

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Gematologiia i transfuziologiia, , Volume: 30, Issue:4, 1985

Reproducibility of the French-American-British classification of acute leukemia: the Southwest Oncology Group Experience.
American journal of hematology, , Volume: 18, Issue:1, 1985

Biphenotypic leukaemia: a case of mixed T lymphoblastic and myeloblastic leukaemia.
Journal of clinical pathology, , Volume: 38, Issue:5, 1985

NALL-1, an acute lymphoblastic leukemia cell line with peroxidase activity.
In vitro, , Volume: 20, Issue:11, 1984

Scanning electron microscope cytochemistry of normal and leukaemic leukocytes.
Biology of the cell, , Volume: 48, Issue:1, 1983

Myeloperoxidase-deficient polymorphonuclear leucocytes. (I) Incidence in untreated myeloid leukaemia, lymphoid leukaemia and normal humans.
Scandinavian journal of haematology, , Volume: 30, Issue:5, 1983

Persistent deficiency of myeloperoxidase and lactoferrin in granulopoietic cells of patients with acute leukemia.
Haematology and blood transfusion, , Volume: 28, 1983

Symposium: classification of leukemia. 1. The classification of acute leukemia.
Pathology, , Volume: 14, Issue:3, 1982

Philadelphia chromosome-positive blastic leukaemia: ultrastructural and ultracytochemical evidence of basophil and mast cell differentiation.
British journal of haematology, , Volume: 52, Issue:4, 1982

Terminal deoxynucleotidyl transferase-positive acute myeloblastic leukemia.
American journal of hematology, , Volume: 10, Issue:3, 1981

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Sangre, , Volume: 26, Issue:5-C, 1981

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[Comparative value of benzidine and alpha-naphthol for peroxidase reaction in leukemic cell (author's transl)].
Pathologie-biologie, , Volume: 29, Issue:3, 1981

Simple procedure of isolation of myeloperoxidase from leukocytes, pus and bone marrow cells.
Acta medica Polona, , Volume: 21, Issue:2, 1980

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The American journal of pathology, , Volume: 95, Issue:1, 1979

[Myeloperoxidase activity and the digestive capacity of the neutrophils in acute myeloblastic leukemia].
Problemy gematologii i perelivaniia krovi, , Volume: 24, Issue:1, 1979

Ultrastructural study of leukemic cell phagocytosis using the myeloperoxidase reaction.
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Peripheral blood neutrophils in children in remission of acute lymphoblastic leukaemia. Cytochemical investigations.
Acta medica Polona, , Volume: 18, Issue:1, 1977

Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
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Sudan black B and peroxidase positivity in cultured lymphoid cells from patients with B-type chronic lymphocytic leukemia.
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Acute monoblastic leukemia with t(8;16): a distinct clinicopathologic entity; report of a case and review of the literature.
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Granulocyte-colony stimulating factor, granulocyte-macrophage colony stimulating factor and interleukin 4 induce differentiation in the U-937 human monocytic leukemia cell line.
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Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3.
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Distinct lysozyme content in different subtypes of acute myeloid leukaemic cells: an ultrastructural immunogold study.
British journal of haematology, , Volume: 88, Issue:2, 1994

Human cell lines U-937, THP-1 and Mono Mac 6 represent relatively immature cells of the monocyte-macrophage cell lineage.
Leukemia, , Volume: 8, Issue:9, 1994

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Lysosomal granules in leukemic monocytes and their relation to maturation stages.
Haematology and blood transfusion, , Volume: 27, 1981

Ultrastructural cytochemistry of leukaemic cells: characterization of the early small granules of monoblasts.
British journal of haematology, , Volume: 45, Issue:2, 1980

[Myeloperoxidase activity and the digestive capacity of the neutrophils in acute myeloblastic leukemia].
Problemy gematologii i perelivaniia krovi, , Volume: 24, Issue:1, 1979

Ultrastructural study of leukemic cell phagocytosis using the myeloperoxidase reaction.
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Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
British journal of haematology, , Volume: 33, Issue:4, 1976

Significance of transmission electron microscopy in subtyping of monocytic leukemia.
Ultrastructural pathology, , Volume: 33, Issue:2

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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Metabolic Activation of Tofacitinib Mediated by Myeloperoxidase
Chemical research in toxicology, , 12-16, Volume: 32, Issue:12, 2019

Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children.
Disease markers, , Volume: 2018, 2018

The reduction of oxidative stress by nanocomposite Fullerol decreases mucositis severity and reverts leukopenia induced by Irinotecan.
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Protective effects of intravenous immunoglobulin and antimicrobial agents on acute pneumonia in leukopenic mice.
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Role of platelet-activating factor in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice.
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Effect of atorvastatin on 5-fluorouracil-induced experimental oral mucositis.
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Pharmaceutical biology, , Volume: 48, Issue:9, 2010

Effect of Ulinastatin, a human urinary trypsin inhibitor, on the oleic acid-induced acute lung injury in rats via the inhibition of activated leukocytes.
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Macrophage inflammatory protein-2 mediates the bowel injury induced by platelet-activating factor.
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[Morphofunctional state of neutrophil granulocytes in Chernobyl nuclear plant accident clean-up workers with persistent leukopenia].
Likars'ka sprava, , Issue:2, 2002

Potent protective effects of melatonin on experimental spinal cord injury.
Spine, , Apr-01, Volume: 25, Issue:7, 2000

[Clinical patameters associated with oxygen-dependent metabolism in neutrophils in patients with systemic lupus erythematosus and leukocytopenia].
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Neuroprotection by recombinant thrombomodulin.
Thrombosis and haemostasis, , Volume: 83, Issue:3, 2000

Activated neutrophils impair gastric cytoprotection role of neutrophil elastase.
Digestive diseases and sciences, , Volume: 45, Issue:6, 2000

Systemic perfluorocarbons suppress the acute lung inflammation after gastric acid aspiration in rats.
Anesthesia and analgesia, , Volume: 90, Issue:2, 2000

Gastric prostacyclin (PGI2) prevents stress-induced gastric mucosal injury in rats primarily by inhibiting leukocyte activation.
Prostaglandins & other lipid mediators, , Volume: 57, Issue:5-6, 1999

Role of neutrophil elastase in stress-induced gastric mucosal injury in rats.
The Journal of laboratory and clinical medicine, , Volume: 132, Issue:5, 1998

Activated protein C reduces the severity of compression-induced spinal cord injury in rats by inhibiting activation of leukocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-15, Volume: 18, Issue:4, 1998

Role of neutrophil elastase in compression-induced spinal cord injury in rats.
Brain research, , Jul-20, Volume: 799, Issue:2, 1998

[Age- and sex-related chemical sensitivity in white rats].
Meditsina truda i promyshlennaia ekologiia, , Issue:12, 1997

Reduction of spinal cord injury by administration of iloprost, a stable prostacyclin analog.
Journal of neurosurgery, , Volume: 86, Issue:6, 1997

Novel role of prostacyclin in stress-induced gastric mucosal lesion formation in rats.
The Journal of laboratory and clinical medicine, , Volume: 129, Issue:6, 1997

Gabexate mesilate, a synthetic protease inhibitor, prevents compression-induced spinal cord injury by inhibiting activation of leukocytes in rats.
Critical care medicine, , Volume: 25, Issue:5, 1997

Enhancement of the leukocyte-endothelial cell interaction in collecting venules of skeletal muscle by protamine.
The Journal of thoracic and cardiovascular surgery, , Volume: 113, Issue:4, 1997

A case of total peripheral aneosinophilia associated with complete deficiency of myeloperoxidase.
Acta clinica Belgica, , Volume: 51, Issue:4, 1996

Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats.
Blood, , Jan-15, Volume: 87, Issue:2, 1996

Improved survival and reversal of endothelial dysfunction by the 21-aminosteroid, U-74389G in splanchnic ischaemia-reperfusion injury in the rat.
British journal of pharmacology, , Volume: 115, Issue:3, 1995

Platelet activating factor interaction with tumor necrosis factor in myocardial ischaemia-reperfusion injury.
Journal of lipid mediators, , Volume: 8, Issue:1, 1993

Leukocytes mediate acid aspiration-induced multiorgan edema.
Surgery, , Volume: 114, Issue:1, 1993

Leukocytes in carbon monoxide-mediated brain oxidative injury.
Toxicology and applied pharmacology, , Volume: 123, Issue:2, 1993

[The hematological and biochemical changes in workers exposed to benzol].
Problemi na khigienata, , Volume: 17, 1992

Sepsis- and endotoxin-induced increase in organ glucose uptake in leukocyte-depleted rats.
The American journal of physiology, , Volume: 263, Issue:6 Pt 2, 1992

Effect of cuprophan, hemophan and polysulfone membranes on the oxidative metabolism, degranulation reaction, enzyme release and pulmonary sequestration of granulocytes.
Contributions to nephrology, , Volume: 74, 1989

[The detection of rare cellular events using scanning cytometry].
Pathologie-biologie, , Volume: 36, Issue:1, 1988

Relationship between leukopenia and bone marrow myeloperoxidase in the rat treated with propylthiouracil.
Japanese journal of pharmacology, , Volume: 36, Issue:2, 1984

Automated cytochemical staining and inflammation. Further assessment of the "left shift".
American journal of clinical pathology, , Volume: 78, Issue:4, 1982

Enzymatic deficiencies of the immune system cells in patients with cancer of the larynx and other malignancies.
Auris, nasus, larynx, , Volume: 12, Issue:1, 1985

Two opposite extremes of adiposity similarly reduce inflammatory response of antigen-induced acute joint inflammation.
Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 33, 2017

Fever, lipodystrophy and cutaneous lesions.
Clinical and experimental dermatology, , Volume: 42, Issue:8, 2017

Histologic and Immunohistochemical Features of the Skin Lesions in CANDLE Syndrome.
The American Journal of dermatopathology, , Volume: 37, Issue:7, 2015

Genetic disorders of lysosomes.
Progress in medical genetics, , Volume: 1, 1976

Liver injury and abscess formation in secondary murine peritonitis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 60, Issue:4, 2011

Leukocyte myeloperoxidase deficiency and diabetes mellitus associated with Candida albicans liver abscess.
The American journal of medicine, , Volume: 66, Issue:1, 1979

[Hereditary myeloperoxidase deficiency. Clinical, biological and genetic study].
Schweizerische medizinische Wochenschrift, , Oct-15, Volume: 107, Issue:41, 1977

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Relationship between disease severity and myeloperoxidase in chronic viral hepatitis: a prospective study.
Biomarkers in medicine, , Volume: 17, Issue:6, 2023

Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease.
American journal of physiology. Gastrointestinal and liver physiology, , Oct-01, Volume: 323, Issue:4, 2022

Neutrophil extracellular traps in patients with liver cirrhosis and hepatocellular carcinoma.
Scientific reports, , 09-09, Volume: 11, Issue:1, 2021

Myeloperoxidase and calprotectin; Any role as non-invasive markers for the prediction of ınflammation and fibrosis in non-alcoholic steatohepatitis?
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, , Volume: 31, Issue:10, 2020

Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice.
Digestive diseases and sciences, , Volume: 64, Issue:9, 2019

Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats.
International journal of pharmaceutics, , Sep-05, Volume: 548, Issue:1, 2018

Treatment with milk thistle extract (Silybum marianum), ursodeoxycholic acid, or their combination attenuates cholestatic liver injury in rats: Role of the hepatic stem cells.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, , Volume: 28, Issue:6, 2017

[no title available]
Applied physics. B, Lasers and optics, , Volume: 122, Issue:12, 2016

Carvedilol Improves Inflammatory Response, Oxidative Stress and Fibrosis in the Alcohol-Induced Liver Injury in Rats by Regulating Kuppfer Cells and Hepatic Stellate Cells.
PloS one, , Volume: 11, Issue:2, 2016

Myeloperoxidase-Hepatocyte-Stellate Cell Cross Talk Promotes Hepatocyte Injury and Fibrosis in Experimental Nonalcoholic Steatohepatitis.
Antioxidants & redox signaling, , Dec-01, Volume: 23, Issue:16, 2015

Myeloperoxidase gene polymorphism predicts fibrosis severity in women with hepatitis C.
Human immunology, , Volume: 75, Issue:8, 2014

Protective effects of rutin on liver injury induced by biliary obstruction in rats.
Free radical biology & medicine, , Volume: 73, 2014

The optimal time window of ischemic preconditioning (IPC) on the reperfusion injury in moderate to severe hepatocirrhosis in rats.
Annals of clinical and laboratory science, ,Winter, Volume: 43, Issue:1, 2013

Combination therapy with taurine, epigallocatechin gallate and genistein for protection against hepatic fibrosis induced by alcohol in rats.
Biological & pharmaceutical bulletin, , Volume: 35, Issue:10, 2012

A variant in myeloperoxidase promoter hastens the emergence of hepatocellular carcinoma in patients with HCV-related cirrhosis.
Journal of hepatology, , Volume: 56, Issue:2, 2012

Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice.
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Redox balance in the pathogenesis of nonalcoholic fatty liver disease: mechanisms and therapeutic opportunities.
Antioxidants & redox signaling, , Sep-01, Volume: 15, Issue:5, 2011

Do genetic variations in antioxidant enzymes influence the course of hereditary hemochromatosis?
Antioxidants & redox signaling, , Jul-01, Volume: 15, Issue:1, 2011

Plasma myeloperoxidase activity and apolipoprotein A-1 expression in chronic hepatitis B patients.
Archives of Iranian medicine, , Volume: 14, Issue:4, 2011

Clinical significance of a myeloperoxidase gene polymorphism and inducible nitric oxide synthase expression in cirrhotic patients with hepatopulmonary syndrome.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, , Volume: 30, Issue:4, 2010

Oxidant and antioxidant of arylesterase and paraoxonase as biomarkers in patients with hepatitis C virus.
Clinical biochemistry, , Volume: 42, Issue:13-14, 2009

Ghrelin alleviates biliary obstruction-induced chronic hepatic injury in rats.
Regulatory peptides, , Feb-07, Volume: 146, Issue:1-3, 2008

Pomegranate peel extract prevents liver fibrosis in biliary-obstructed rats.
The Journal of pharmacy and pharmacology, , Volume: 59, Issue:9, 2007

Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis.
Journal of hepatology, , Volume: 42, Issue:6, 2005

Deficient phospholipase C activity in blood polimorphonuclear neutrophils from patients with liver cirrhosis.
Journal of hepatology, , Volume: 40, Issue:5, 2004

Tezosentan, an endothelin receptor antagonist, limits liver injury in endotoxin challenged cirrhotic rats.
Gut, , Volume: 53, Issue:12, 2004

A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection.
Genes and immunity, , Volume: 3, Issue:6, 2002

The role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride.
Toxicology and applied pharmacology, , Dec-01, Volume: 177, Issue:2, 2001

Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells.
The Journal of biological chemistry, , Jul-06, Volume: 276, Issue:27, 2001

Patients with stable uncomplicated cirrhosis have normal neutrophil function.
Journal of gastroenterology and hepatology, , Volume: 15, Issue:11, 2000

Sensitive enzymatic assay for erythrocyte creatine with production of methylene blue.
Clinical chemistry, , Volume: 44, Issue:7, 1998

High plasma concentration of myeloperoxidase in cirrhosis: a possible marker of hypersplenism.
Hepatology (Baltimore, Md.), , Volume: 18, Issue:6, 1993

Decreased production of active oxygen species by neutrophils in patients with liver cirrhosis and hepatocellular carcinoma.
Gastroenterologia Japonica, , Volume: 28, Issue:4, 1993

Plasma myeloperoxidase and lactoferrin measured by radioimmunoassay: relations to neutrophil kinetics.
Acta medica Scandinavica, , Volume: 198, Issue:6, 1975

Levels of malondialdehyde, myeloperoxidase and nitrotyrosine in patients with chronic viral hepatitis B and C.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, , Volume: 21, Issue:1

Is intestinal oxidative stress involved in patients with compensated liver cirrhosis?
Annals of hepatology, , Volume: 15, Issue:3

Reduced post-operative neutrophil activation in liver transplant recipients suffering from post-hepatitic cirrhosis.
Clinical transplantation, , Volume: 23, Issue:6

Restoration of bactericidal activity of neutrophils by myeloperoxidase release: A new perspective for preventing infection in alcoholic cirrhosis.
Journal of hepatology, , Volume: 64, Issue:5, 2016

Impaired intracellular signaling, myeloperoxidase release and bactericidal activity of neutrophils from patients with alcoholic cirrhosis.
Journal of hepatology, , Volume: 64, Issue:5, 2016

Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis.
Hepatology (Baltimore, Md.), , Volume: 50, Issue:5, 2009

Neutrophil and eosinophil involvement of the small bowel affected by chronic alcoholism.
Gut, , Volume: 29, Issue:12, 1988

Polymorph leucocyte function in uraemia and jaundice.
Acta haematologica, , Volume: 64, Issue:3, 1980

Erdosteine treatment attenuates oxidative stress and fibrosis in experimental biliary obstruction.
Pediatric surgery international, , Volume: 23, Issue:3, 2007

SLE and rapidly progressive glomerulonephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 45, Issue:5, 2005

Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss.
The Journal of pathology, , Volume: 205, Issue:4, 2005

Antineutrophil cytoplasmic autoantibody-associated rapidly progressive glomerulonephritis in a patient with primary biliary cirrhosis.
The American journal of the medical sciences, , Volume: 328, Issue:3, 2004

Myeloperoxidase-positive inflammatory cells participate in bile duct damage in primary biliary cirrhosis through nitric oxide-mediated reactions.
Hepatology (Baltimore, Md.), , Volume: 38, Issue:4, 2003

Goodpasture's syndrome associated with primary biliary cirrhosis.
Internal medicine (Tokyo, Japan), , Volume: 37, Issue:7, 1998

Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 303, Issue:1, 2012

ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 280, Issue:6, 2001

Myeloperoxidase-Sensitive
ACS nano, , 02-28, Volume: 17, Issue:4, 2023

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Neutrophil extracellular traps in patients with liver cirrhosis and hepatocellular carcinoma.
Scientific reports, , 09-09, Volume: 11, Issue:1, 2021

Co-Administration of iRGD with Sorafenib-Loaded Iron-Based Metal-Organic Framework as a Targeted Ferroptosis Agent for Liver Cancer Therapy.
International journal of nanomedicine, , Volume: 16, 2021

Serum Matrix Metalloproteinase-8 and Myeloperoxidase Predict Survival after Resection of Colorectal Liver Metastases.
Oncology, , Volume: 99, Issue:12, 2021

High Expression of MMP-9 in Primary Tumors and High Preoperative MPO in Serum Predict Improved Prognosis in Colorectal Cancer with Operable Liver Metastases.
Oncology, , Volume: 99, Issue:3, 2021

N-acetylcysteine alleviates liver injury by suppressing macrophage-mediated inflammatory response post microwave ablation.
International immunopharmacology, , Volume: 85, 2020

Nanozyme-assisted sensitive profiling of exosomal proteins for rapid cancer diagnosis.
Theranostics, , Volume: 10, Issue:20, 2020

Biomineralization Synthesis of the Cobalt Nanozyme in SP94-Ferritin Nanocages for Prognostic Diagnosis of Hepatocellular Carcinoma.
ACS applied materials & interfaces, , Mar-13, Volume: 11, Issue:10, 2019

Hepatoprotective effects of limb ischemic post-conditioning in hepatic ischemic rat model and liver cancer patients via PI3K/ERK pathways.
International journal of biological sciences, , Volume: 14, Issue:14, 2018

Loss of SMAD4 from colorectal cancer cells promotes CCL15 expression to recruit CCR1+ myeloid cells and facilitate liver metastasis.
Gastroenterology, , Volume: 145, Issue:5, 2013

A variant in myeloperoxidase promoter hastens the emergence of hepatocellular carcinoma in patients with HCV-related cirrhosis.
Journal of hepatology, , Volume: 56, Issue:2, 2012

Plasma myeloperoxidase levels correlate with hepatocellular carcinoma in chronic hepatitis C.
Human immunology, , Volume: 73, Issue:11, 2012

Do genetic variations in antioxidant enzymes influence the course of hereditary hemochromatosis?
Antioxidants & redox signaling, , Jul-01, Volume: 15, Issue:1, 2011

Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis.
Hepatology (Baltimore, Md.), , Volume: 50, Issue:5, 2009

[Study on polymorphisms in metabolic enzyme genes, DNA repair genes and individual susceptibility to hepatocellular carcinoma].
Wei sheng yan jiu = Journal of hygiene research, , Volume: 35, Issue:6, 2006

Beneficial effects of ischemic preconditioning in patients undergoing hepatectomy: the role of neutrophils.
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Myeloperoxidase promotor polymorphism and risk of hepatoblastoma.
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[Effect of endogenous biotin on SP immunohistochemical result].
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, , Volume: 28, Issue:2, 2003

DA-125, a novel anthracycline derivative showing high-affinity DNA binding and topoisomerase II inhibitory activities, exerts cytotoxicity via c-Jun N-terminal kinase pathway.
Cancer chemotherapy and pharmacology, , Volume: 47, Issue:6, 2001

Enhanced anti-tumor effects of herpes simplex virus thymidine kinase/ganciclovir system by codelivering monocyte chemoattractant protein-1 in hepatocellular carcinoma.
Cancer gene therapy, , Volume: 8, Issue:10, 2001

Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.
Molecular and cellular endocrinology, , Jul-25, Volume: 142, Issue:1-2, 1998

Decreased production of active oxygen species by neutrophils in patients with liver cirrhosis and hepatocellular carcinoma.
Gastroenterologia Japonica, , Volume: 28, Issue:4, 1993

Comparison of protein components of the plasma membrane fraction from rat liver and Morris hepatomas 5123D and 7777.
Folia histochemica et cytochemica, , Volume: 14, Issue:3, 1976

Intracellular distribution of enzymes; the distribution of succinic dehydrogenase, cytochrome oxidase, adenosinetriphosphatase, and phosphorus compounds in normal rat liver and in rat hepatomas.
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Eosinophilic nodules.
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[Preparation of immunoenzymatic reagents for the quantitative determination of human alpha-1-fetoprotein (ELISA-AFP)].
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Clinical course in a patient with neutrophil-specific granule deficiency and rapid detection of neutrophil granules as a screening test.
Journal of clinical immunology, , Volume: 34, Issue:7, 2014

Time course of inflammation resolution in patients with frequent exacerbations of chronic obstructive pulmonary disease.
Medical science monitor : international medical journal of experimental and clinical research, , Feb-25, Volume: 20, 2014

Myeloperoxidase concentration in bronchoalveolar lavage fluid from healthy horses and those with recurrent airway obstruction.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, , Volume: 70, Issue:4, 2006

Granulocyte markers in induced sputum in patients with respiratory disorders and healthy persons obtained by two sputum-processing methods.
Respiratory medicine, , Volume: 95, Issue:1, 2001

Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine, , Volume: 163, Issue:2, 2001

Serum ECP and MPO are increased during exacerbations of chronic bronchitis with airway obstruction.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 54, Issue:5, 2000

Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitis.
The American journal of medicine, , Volume: 109, Issue:4, 2000

Validation of assays for inflammatory mediators in sputum.
The European respiratory journal, , Volume: 15, Issue:4, 2000

Evidence for excessive bronchial inflammation during an acute exacerbation of chronic obstructive pulmonary disease in patients with alpha(1)-antitrypsin deficiency (PiZ).
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Airway inflammation in COPD assessed by sputum levels of interleukin-8.
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Interleukin-8 in airway inflammation in patients with asthma and chronic obstructive pulmonary disease.
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Factors related to impaired bactericidal activity in patients with esophageal cancer.
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Plasma protein leakage and local secretion of proteins assessed in sputum in asthma and COPD. The effect of inhaled corticosteroids.
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Bronchial inflammation in chronic bronchitis assessed by measurement of cell products in bronchial lavage fluid.
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Neutrophil mediators, Pseudomonas, and pulmonary dysfunction in cystic fibrosis.
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Airway inflammation in smokers with nonobstructive and obstructive chronic bronchitis.
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Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease.
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Thymostimulin administration modulates polymorph metabolic pathway in patients with chronic obstructive pulmonary disease.
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European journal of respiratory diseases. Supplement, , Volume: 139, 1985

Increased neutrophil myeloperoxidase activity associated with cigarette smoking.
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Protection of alpha-1 protease inhibitor by plasma antioxidants. Potential abnormality in chronic obstructive pulmonary disease (COPD).
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The release of elastase, myeloperoxidase, and lysozyme from human alveolar macrophages.
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Antineutrophil Cytoplasmic Antibody in Lupus Nephritis: Correlation with Clinicopathological Characteristics and Disease Activity.
Current rheumatology reviews, , Volume: 17, Issue:2, 2021

Role of Neutrophil Extracellular Traps Regarding Patients at Risk of Increased Disease Activity and Cardiovascular Comorbidity in Systemic Lupus Erythematosus.
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ANCA positivity at the time of renal biopsy is associated with chronicity index of lupus nephritis.
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Hydralazine-induced MPO-ANCA Renal-Limited Vasculitis Masquerading as Lupus Nephritis.
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Positive antineutrophil cytoplasmic antibody serology in patients with lupus nephritis is associated with distinct histopathologic features on renal biopsy.
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Antinuclear Antibody-Negative Lupus Nephritis with Full House Nephropathy: A Case Report and Review of the Literature.
American journal of nephrology, , Volume: 42, Issue:6, 2015

Suppression of Autoimmunity and Renal Disease in Pristane-Induced Lupus by Myeloperoxidase.
Arthritis & rheumatology (Hoboken, N.J.), , Volume: 67, Issue:7, 2015

Successful Management of Lupus Nephritis with High Titers of Myeloperoxidase Anti-Neutrophil Cytoplasmic Antibodies Using Tacrolimus.
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Lupus nephritis with positive myeloperoxidase/proteinase 3-antineutrophil cytoplasmic autoantibody that developed after 17 years of propylthiouracil therapy.
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Diffuse alveolar hemorrhage in lupus nephritis complicated by microscopic polyangiitis.
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Improvement of rapidly progressive lupus nephritis associated MPO-ANCA with tacrolimus.
Modern rheumatology, , Volume: 20, Issue:3, 2010

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Necrotizing and crescentic lupus nephritis with antineutrophil cytoplasmic antibody seropositivity.
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Lupus nephritis associated with positive MPO-ANCA in a patient with underlying autoimmune hemolytic anemia.
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SLE and rapidly progressive glomerulonephritis.
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Use of immunofluorescence and confocal laser scanning microscopy in identifying rare cases of anti-neutrophil cytoplasmic antibodies (ANCA) showing dual specificities to myeloperoxidase and proteinase3.
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Pathogenesis of lupus nephritis and ANCA-associated systemic vasculitis: lessons from experimental models.
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Distribution of antineutrophil cytoplasmic autoantibodies in SLE patients with and without renal involvement.
American journal of nephrology, , Volume: 16, Issue:6, 1996

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Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis.
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Design and Mechanism Insight of Monodispersed AuCuPt Alloy Nanozyme with Antitumor Activity.
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Nanozyme: a rising star for cancer therapy.
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Enhancing Catalytic Activity of a Nickel Single Atom Enzyme by Polynary Heteroatom Doping for Ferroptosis-Based Tumor Therapy.
ACS nano, , 02-14, Volume: 17, Issue:3, 2023

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Carbon-Encapsulated Magnetite Nanodoughnut as a NIR-II Responsive Nanozyme for Synergistic Chemodynamic-Photothermal Therapy.
Advanced healthcare materials, , Volume: 12, Issue:29, 2023

Metal-Free Peroxidase-Mimetic Nanocatalysts for Chemodynamic Vascular-Disrupting Cancer Therapy.
Advanced healthcare materials, , Volume: 12, Issue:28, 2023

Dual Nanozyme-Driven PtSn Bimetallic Nanoclusters for Metal-Enhanced Tumor Photothermal and Catalytic Therapy.
ACS nano, , 04-11, Volume: 17, Issue:7, 2023

Cascaded Nanozyme with In Situ Enhanced Photothermal Capacity for Tumor-Specific and Self-Replenishing Cancer Therapy.
Advanced healthcare materials, , Volume: 12, Issue:27, 2023

The role of peroxidasin in solid cancer progression.
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The rational design of nanozymes for imaging-monitored cancer therapy.
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Core-Shell Au@Pd Bimetallic Nanozyme Mediated Mild Photothermal Therapy through Reactive Oxygen Species-Regulating Tumor Thermoresistance.
ACS applied materials & interfaces, , Nov-29, Volume: 15, Issue:47, 2023

Dual enzyme-mimic nanozyme based on single-atom construction strategy for photothermal-augmented nanocatalytic therapy in the second near-infrared biowindow.
Biomaterials, , Volume: 281, 2022

Myeloperoxidase: Growing importance in cancer pathogenesis and potential drug target.
Pharmacology & therapeutics, , Volume: 236, 2022

Non-Canonical Functions of Myeloperoxidase in Immune Regulation, Tissue Inflammation and Cancer.
International journal of molecular sciences, , Oct-14, Volume: 23, Issue:20, 2022

Galectin-3 and Myeloperoxidase May Monitor Cancer-Therapy-Related Cardiotoxicity? A Systematic Review and Meta-Analysis.
Biomolecules, , 11-30, Volume: 12, Issue:12, 2022

A Bioinspired Five-Coordinated Single-Atom Iron Nanozyme for Tumor Catalytic Therapy.
Advanced materials (Deerfield Beach, Fla.), , Volume: 34, Issue:15, 2022

A Platelet-Mimicking Single-Atom Nanozyme for Mitochondrial Damage-Mediated Mild-Temperature Photothermal Therapy.
ACS applied materials & interfaces, , May-04, Volume: 14, Issue:17, 2022

Mesoporous peroxidase nanozyme for synergistic chemodynamic therapy and chemotherapy.
Colloids and surfaces. B, Biointerfaces, , Volume: 216, 2022

A Calcium Fluoride Nanozyme for Ultrasound-Amplified and Ca
Advanced materials (Deerfield Beach, Fla.), , Volume: 34, Issue:43, 2022

Catalase-Like Nanozymes: Classification, Catalytic Mechanisms, and Their Applications.
Small (Weinheim an der Bergstrasse, Germany), , Volume: 18, Issue:37, 2022

Peroxiredoxin, Senescence, and Cancer.
Cells, , 05-28, Volume: 11, Issue:11, 2022

Cell membrane-coated nanoparticles as peroxidase mimetics for cancer cell targeted detection and therapy.
Talanta, , Feb-01, Volume: 238, Issue:Pt 2, 2022

Rare germline alterations of myeloperoxidase predispose to myeloid neoplasms.
Leukemia, , Volume: 36, Issue:8, 2022

Peroxidase Mimetic Nanozymes in Cancer Phototherapy: Progress and Perspectives.
Biomolecules, , 07-11, Volume: 11, Issue:7, 2021

Specific "Unlocking" of a Nanozyme-Based Butterfly Effect To Break the Evolutionary Fitness of Chaotic Tumors.
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Polymorphonuclear myeloid-derived suppressor cells limit antigen cross-presentation by dendritic cells in cancer.
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Neutrophil traps, anti-myeloperoxidase antibodies and cancer: Are they linked?
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Oxygen-Deficient Bimetallic Oxide FeWO
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All-cause and cause-specific mortality in ANCA-associated vasculitis: overall and according to ANCA type.
Rheumatology (Oxford, England), , 09-01, Volume: 59, Issue:9, 2020

The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease.
Antioxidants & redox signaling, , 05-01, Volume: 32, Issue:13, 2020

Effect of myeloperoxidase on the anticoagulant activity of low molecular weight heparin and rivaroxaban in an in vitro tumor model.
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Key Features Relevant to Select Antigens and TCR From the MHC-Mismatched Repertoire to Treat Cancer.
Frontiers in immunology, , Volume: 10, 2019

ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism.
Science translational medicine, , 03-13, Volume: 11, Issue:483, 2019

The other myeloperoxidase: Emerging functions.
Archives of biochemistry and biophysics, , 07-01, Volume: 649, 2018

Hypochlorous Acid Promoted Platinum Drug Chemotherapy by Myeloperoxidase-Encapsulated Therapeutic Metal Phenolic Nanoparticles.
ACS nano, , 01-23, Volume: 12, Issue:1, 2018

The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases.
Thrombosis and haemostasis, , Volume: 118, Issue:1, 2018

Phase I/II study of mocetinostat in combination with gemcitabine for patients with advanced pancreatic cancer and other advanced solid tumors.
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Redox and Peroxidase Activities of the Hemoglobin Superfamily: Relevance to Health and Disease.
Antioxidants & redox signaling, , 05-10, Volume: 26, Issue:14, 2017

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Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy.
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Surface-Enhanced Raman Scattering Active Gold Nanoparticles with Enzyme-Mimicking Activities for Measuring Glucose and Lactate in Living Tissues.
ACS nano, , 06-27, Volume: 11, Issue:6, 2017

Colorimetric detection of glutathione in cells based on peroxidase-like activity of gold nanoclusters: A promising powerful tool for identifying cancer cells.
Analytica chimica acta, , May-15, Volume: 967, 2017

CD4 T cell knockout does not protect against kidney injury and worsens cancer.
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Incidence of Malignancies in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Diagnosed Between 1991 and 2013.
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Techniques to access histone modifications and variants in cancer.
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Size- and shape-dependent peroxidase-like catalytic activity of MnFe2O4 Nanoparticles and their applications in highly efficient colorimetric detection of target cancer cells.
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Selective and quantitative cancer cell detection using target-directed functionalized graphene and its synergetic peroxidase-like activity.
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Genetic polymorphisms in the Hmong population: implications for cancer etiology and survival.
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Increased myeloperoxidase index and large unstained cell values can predict the neutropenia phase of cancer patients treated with standard dose chemotherapy.
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Consequences of total and subtotal myeloperoxidase deficiency: risk or benefit ?
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Attenuating effect of hydroalcoholic extract of Acorus calamus in vincristine-induced painful neuropathy in rats.
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Neutrophils mediate pulmonary vasomotor dysfunction in endotoxin-induced acute lung injury.
The Journal of trauma, , Volume: 42, Issue:3, 1997

The role of neutrophils in the production of hypoxic-ischemic brain injury in the neonatal rat.
Pediatric research, , Volume: 41, Issue:5, 1997

Evaluation of the role of neutrophils in the pathogenesis of acetic acid-induced colitis in mice.
Scandinavian journal of gastroenterology, , Volume: 32, Issue:6, 1997

Induction of cytokine-induced neutrophil chemoattractant (CINC) mRNA in the lungs of septic rats.
The Journal of trauma, , Volume: 41, Issue:2, 1996

Role of neutrophil depletion and elastase inhibition in modifying skeletal muscle reperfusion injury.
Cardiovascular surgery (London, England), , Volume: 2, Issue:6, 1994

Neutrophil-independence of the initiation of colonic injury. Comparison of results from three models of experimental colitis in the rat.
Digestive diseases and sciences, , Volume: 39, Issue:12, 1994

Mean myeloperoxidase index in lymphoma transplants receiving recombinant granulocyte-macrophage colony stimulating factor.
Bone marrow transplantation, , Volume: 11, Issue:4, 1993

Effect of pulmonary thromboembolism on circulating neutrophils in mice.
Thrombosis research, , May-01, Volume: 66, Issue:2-3, 1992

Effects of recombinant canine granulocyte colony-stimulating factor on white blood cell production in clinically normal and neutropenic dogs.
Journal of the American Veterinary Medical Association, , Jun-15, Volume: 200, Issue:12, 1992

[The hematological and biochemical changes in workers exposed to benzol].
Problemi na khigienata, , Volume: 17, 1992

Patterns of primary degranulation as indicated by the mean myeloperoxidase index (MPXI) during bacteraemia in lymphoma transplants treated with growth factors.
Clinical and laboratory haematology, , Volume: 14, Issue:4, 1992

ONO-LB-457: a novel and orally active leukotriene B4 receptor antagonist.
Advances in prostaglandin, thromboxane, and leukotriene research, , Volume: 21A, 1991

Neutrophil-dependent decrease in early wound margin strength.
Archives of surgery (Chicago, Ill. : 1960), , Volume: 126, Issue:11, 1991

Endotoxemia and neutrophil activation in vivo.
The American journal of physiology, , Volume: 254, Issue:5 Pt 2, 1988

Acquired myeloperoxidase deficiency of neutrophils in a patient with aplastic anemia (idiopathic marrow aplasia).
Acta haematologica, , Volume: 80, Issue:2, 1988

Serum levels of lactoferrin and myeloperoxidase in chronic idiopathic and secondary neutropenia. A preliminary report.
Scandinavian journal of haematology, , Volume: 36, Issue:4, 1986

Myeloperoxidase-deficient polymorphonuclear leucocytes. (V): Relation to FAB-classification and neutrophil alkaline phosphatase activity in primary myelodysplastic syndromes.
Scandinavian journal of haematology, , Volume: 35, Issue:2, 1985

[Role of neutrophilic leukocytes in the immune response to infection].
Revista clinica espanola, , Dec-31, Volume: 167, Issue:6, 1982

The antimicrobial role of the neutrophil leukocyte.
The Journal of infection, , Volume: 3, Issue:1, 1981

In vitro evaluation of opsonic and cellular granulocyte function by luminol-dependent chemiluminescence: utility in patients with severe neutropenia and cellular deficiency states.
Infection and immunity, , Volume: 22, Issue:1, 1978

The oxidative killing mechanisms of the neutrophil.
Progress in clinical immunology, , Volume: 3, 1977

Serum myeloperoxidase and lactoferrin in neutropenia.
Scandinavian journal of haematology, , Volume: 18, Issue:1, 1977

Cell production and cell function in human cyclic neutropenia.
Scandinavian journal of haematology, , Volume: 15, Issue:3, 1975

Defective polymorphonuclear leukocyte metabolism and function in canine cyclic neutropenia.
Blood, , Volume: 46, Issue:6, 1975

[Chemoluminescence of the human neutrophilic granulocyte, II. Origin, normal values, hereditary deficiencies].
Revista de igiena, bacteriologie, virusologie, parazitologie, epidemiologie, pneumoftiziologie. Bacteriologia, virusologia, parazitologia, epidemiologia, , Volume: 30, Issue:3

Preventive effect of neutropenia on carbon tetrachloride-induced hepatotoxicity in rats.
Journal of applied toxicology : JAT, , Volume: 26, Issue:2

Noma-like gangrenous cheilitis in a child with cyclic neutropenia associated with myeloperoxidase deficiency.
Pediatric dermatology, , Volume: 20, Issue:6

Genetic disorders of lysosomes.
Progress in medical genetics, , Volume: 1, 1976

Factors related to impaired bactericidal activity in patients with esophageal cancer.
Surgery today, , Volume: 25, Issue:4, 1995

[Evaluation of granulocytes in children with malnutrition].
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Revista clinica espanola, , Dec-31, Volume: 167, Issue:6, 1982

Sleeve Gastrectomy Provides Cardioprotection from Oxidative Stress In Vitro Due to Reduction of Circulating Myeloperoxidase.
Nutrients, , Nov-14, Volume: 15, Issue:22, 2023

Myeloperoxidase enzyme and Ferric-reducing antioxidant power concentrations in lean and obese dogs.
Veterinary research communications, , Volume: 47, Issue:2, 2023

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Protective effect of indole-3-carbinol on testis of a high fat diet induced obesity.
Biotechnic & histochemistry : official publication of the Biological Stain Commission, , Volume: 98, Issue:1, 2023

Changes of Metabolic Biomarker Levels upon One-Year Anti-TNF-α Therapy in Rheumatoid Arthritis and Ankylosing Spondylitis: Associations with Vascular Pathophysiology.
Biomolecules, , 10-18, Volume: 11, Issue:10, 2021

Intravenous calcitriol administration regulates the renin-angiotensin system and attenuates acute lung injury in obese mice complicated with polymicrobial sepsis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 141, 2021

Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes.
Scientific reports, , 04-10, Volume: 10, Issue:1, 2020

Postprandial activation of leukocyte-endothelium interaction by fatty acids in the visceral adipose tissue microcirculation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 33, Issue:11, 2019

Effects of Obesity on Pulmonary Inflammation and Remodeling in Experimental Moderate Acute Lung Injury.
Frontiers in immunology, , Volume: 10, 2019

Identification of Orexin and Endocannabinoid Receptors in Adult Zebrafish Using Immunoperoxidase and Immunofluorescence Methods.
Journal of visualized experiments : JoVE, , 06-25, Issue:148, 2019

Pharmacological myeloperoxidase (MPO) inhibition in an obese/hypertensive mouse model attenuates obesity and liver damage, but not cardiac remodeling.
Scientific reports, , 12-10, Volume: 9, Issue:1, 2019

Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects.
Molecular biology reports, , Volume: 45, Issue:5, 2018

Acute lung injury induced by intestinal ischemia and reperfusion is altered in obese female mice.
Pulmonary pharmacology & therapeutics, , Volume: 49, 2018

Oxidized Low-Density Lipoprotein and Cell Adhesion Molecules Following Exercise Training.
International journal of sports medicine, , Volume: 39, Issue:2, 2018

Chronic supplementation with dietary proanthocyanidins protects from diet-induced intestinal alterations in obese rats.
Molecular nutrition & food research, , Volume: 61, Issue:8, 2017

A cafeteria diet triggers intestinal inflammation and oxidative stress in obese rats.
The British journal of nutrition, , Volume: 117, Issue:2, 2017

Two opposite extremes of adiposity similarly reduce inflammatory response of antigen-induced acute joint inflammation.
Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 33, 2017

Paraoxonase-1 arylesterase activity is an independent predictor of myeloperoxidase levels in overweight patients with or without cardiovascular complications.
Clinical biochemistry, , Volume: 49, Issue:12, 2016

Green tea polyphenol extract in vivo attenuates inflammatory features of neutrophils from obese rats.
European journal of nutrition, , Volume: 55, Issue:3, 2016

Biomarkers in Obesity: Serum Myeloperoxidase and Traditional Cardiac Risk Parameters.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, , Volume: 124, Issue:1, 2016

Association of myeloperoxidase levels with cardiometabolic factors and renal function in prepubertal children.
European journal of clinical investigation, , Volume: 46, Issue:1, 2016

Advanced Glycation End Products Induce Obesity and Hepatosteatosis in CD-1 Wild-Type Mice.
BioMed research international, , Volume: 2016, 2016

Circulating Advanced Oxidation Protein Products as Oxidative Stress Biomarkers and Progression Mediators in Pathological Conditions Related to Inflammation and Immune Dysregulation.
Current medicinal chemistry, , Volume: 23, Issue:34, 2016

Lifestyle predictors of oxidant and antioxidant enzyme activities and total antioxidant capacity in healthy women: a cross-sectional study.
Journal of physiology and biochemistry, , Volume: 72, Issue:4, 2016

The influence of body mass index on the accumulation of advanced glycation end products in hemodialysis patients.
European journal of clinical nutrition, , Volume: 69, Issue:3, 2015

Aerobic training suppresses exercise-induced lipid peroxidation and inflammation in overweight/obese adolescent girls.
Pediatric exercise science, , Volume: 27, Issue:1, 2015

Neutrophil release of myeloperoxidase in systemic vasculature of obese women may put them at risk for preeclampsia.
Reproductive sciences (Thousand Oaks, Calif.), , Volume: 22, Issue:3, 2015

Paraoxonase responses to exercise and niacin therapy in men with metabolic syndrome.
Redox report : communications in free radical research, , Volume: 20, Issue:1, 2015

MicroRNA -143 and -223 in obesity.
Gene, , Apr-15, Volume: 560, Issue:2, 2015

β(2)-Adrenoreceptor blockade improves early posttrauma hyperglycemia and pulmonary injury in obese rats.
American journal of physiology. Heart and circulatory physiology, , Aug-15, Volume: 307, Issue:4, 2014

Inhibition of NADPH oxidase prevents acute lung injury in obese rats following severe trauma.
American journal of physiology. Heart and circulatory physiology, , Mar-01, Volume: 306, Issue:5, 2014

A low-frequency variant in MAPK14 provides mechanistic evidence of a link with myeloperoxidase: a prognostic cardiovascular risk marker.
Journal of the American Heart Association, , Aug-27, Volume: 3, Issue:4, 2014

Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance.
Diabetes, , Volume: 63, Issue:12, 2014

Myeloperoxidase: a therapeutic target for preventing insulin resistance and the metabolic sequelae of obesity?
Diabetes, , Volume: 63, Issue:12, 2014

Obesity increases eosinophil activity in asthmatic children and adolescents.
BMC pulmonary medicine, , Jun-18, Volume: 13, 2013

Evaluation of plasmatic MMP-8, MMP-9, TIMP-1 and MPO levels in obese and lean women.
Clinical biochemistry, , Volume: 45, Issue:6, 2012

Myeloperoxidase is an early biomarker of inflammation and cardiovascular risk in prepubertal obese children.
Diabetes care, , Volume: 35, Issue:11, 2012

Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes.
The Journal of nutritional biochemistry, , Volume: 23, Issue:4, 2012

Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity.
Mutation research, , Aug-01, Volume: 736, Issue:1-2, 2012

Postprandial endothelial function, inflammation, and oxidative stress in obese children and adolescents.
Obesity (Silver Spring, Md.), , Volume: 19, Issue:6, 2011

Vitamin C status is related to proinflammatory responses and impaired vascular endothelial function in healthy, college-aged lean and obese men.
Journal of the American Dietetic Association, , Volume: 111, Issue:5, 2011

Elevated plasma myeloperoxidase concentration in adults with obesity.
Clinica chimica acta; international journal of clinical chemistry, , Sep-18, Volume: 412, Issue:19-20, 2011

Altered inflammatory, oxidative, and metabolic responses to exercise in pediatric obesity and type 1 diabetes.
Pediatric diabetes, , Volume: 12, Issue:5, 2011

Acute pancreatitis in obesity: adipokines and dietary fish oil.
Digestive diseases and sciences, , Volume: 56, Issue:8, 2011

Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 299, Issue:2, 2010

Differential adipokine response in genetically predisposed lean and obese rats during inflammation: a role in modulating experimental colitis?
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 297, Issue:5, 2009

Leucocyte peroxidase and leptin in obese children as early indices of bronchial asthma.
Panminerva medica, , Volume: 51, Issue:4, 2009

Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis.
The American journal of pathology, , Volume: 175, Issue:4, 2009

A murine model of obesity implicates the adipokine milieu in the pathogenesis of severe acute pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 295, Issue:3, 2008

Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males.
Journal of lipid research, , Volume: 47, Issue:7, 2006

SLE and rapidly progressive glomerulonephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 45, Issue:5, 2005

Fibronectin-alpha 4 beta 1 integrin-mediated blockade protects genetically fat Zucker rat livers from ischemia/reperfusion injury.
The American journal of pathology, , Volume: 162, Issue:4, 2003

Cholesterol feeding exacerbates myocardial injury in Zucker diabetic fatty rats.
American journal of physiology. Heart and circulatory physiology, , Volume: 278, Issue:1, 2000

Zucker diabetic fatty rat: a new model of impaired cutaneous wound repair with type II diabetes mellitus and obesity.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , Volume: 19, Issue:4

Myeloperoxidase 463 G>A and superoxide dismutase Ala16Val gene polymorphisms in obese children.
The Turkish journal of pediatrics, , Volume: 56, Issue:5

Oxidative stress and inflammation in lean and obese subjects with polycystic ovary syndrome.
The Journal of reproductive medicine, , Volume: 58, Issue:3-4

The Impact of Hypertension and Metabolic Syndrome on Nitrosative Stress and Glutathione Metabolism in Patients with Morbid Obesity.
Oxidative medicine and cellular longevity, , Volume: 2020, 2020

Impact of morbid obesity and bariatric surgery on antioxidant/oxidant balance of the unstimulated and stimulated human saliva.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, , Volume: 45, Issue:6, 2016

Moderate-intensity aerobic training program improves insulin sensitivity and inflammatory markers in a pilot study of morbidly obese minority teens.
Pediatric exercise science, , Volume: 25, Issue:1, 2013

Influence of Roux-en-Y gastric bypass surgery on vitamin C, myeloperoxidase, and oral clinical manifestations: a 2-year follow-up study.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, , Volume: 27, Issue:1, 2012

Changes in the mucosa of the Roux-limb after gastric bypass surgery.
Histopathology, , Volume: 57, Issue:5, 2010

Roux-en-Y bypass gastroplasty: markers of oxidative stress 6 months after surgery.
Obesity surgery, , Volume: 20, Issue:9, 2010

Raised serum TSH levels in patients with morbid obesity: is it enough to diagnose subclinical hypothyroidism?
European journal of endocrinology, , Volume: 160, Issue:3, 2009

Neutrophil activation in morbid obesity, chronic activation of acute inflammation.
Obesity (Silver Spring, Md.), , Volume: 17, Issue:11, 2009

Eosinophils, eosinophil cationic protein and eosinophil-derived neurotoxin in serum and urine of patients with onchocerciasis coinfected with intestinal nematodes and in urinary schistosomiasis.
Acta tropica, , Mar-15, Volume: 72, Issue:2, 1999

Serum levels of eosinophil cationic protein, eosinophil-derived neurotoxin and myeloperoxidase in infections with filariae and schistosomes.
Acta tropica, , Dec-16, Volume: 62, Issue:3, 1996

Increased resistance to Staphylococcus aureus endophthalmitis in BALB/c mice: Fas ligand is required for resolution of inflammation but not for bacterial clearance.
Infection and immunity, , Volume: 81, Issue:6, 2013

Role of Toll-like receptor (TLR) 2 in experimental Bacillus cereus endophthalmitis.
PloS one, , Volume: 6, Issue:12, 2011

The Streptococcus pneumoniae capsule is required for full virulence in pneumococcal endophthalmitis.
Investigative ophthalmology & visual science, , Volume: 52, Issue:2, 2011

A role for tumor necrosis factor-alpha in experimental Bacillus cereus endophthalmitis pathogenesis.
Investigative ophthalmology & visual science, , Volume: 49, Issue:10, 2008

Acute inflammation and loss of retinal architecture and function during experimental Bacillus endophthalmitis.
Current eye research, , Volume: 31, Issue:11, 2006

Mitigation of neutrophil infiltration in a rat model of early Staphylococcus aureus endophthalmitis.
Investigative ophthalmology & visual science, , Volume: 44, Issue:7, 2003

PMN accumulation in aqueous humor and iris-ciliary body during intraocular inflammation.
Investigative ophthalmology & visual science, , Volume: 25, Issue:1, 1984

AuNPs-LISA, an efficient detection assay for Opisthorchis viverrini (Ov) antigen in urine.
Talanta, , Mar-01, Volume: 209, 2020

[The myeloperoxidase of the polymorphonuclear leukocytes as a marker of the stage of Opisthorchis invasion and as an indicator of the efficacy of chemotherapy].
Meditsinskaia parazitologiia i parazitarnye bolezni, , Issue:3

[In vitro induced activity of polymorphonuclear leukocyte myeloperoxidase at different stages of opisthorchis invasion and at stages of a different rehabilitative period].
Meditsinskaia parazitologiia i parazitarnye bolezni, , Issue:3

Eye manifestations in patients with perinuclear antineutrophil cytoplasmic antibody-associated vasculitis: case series and literature review.
Japanese journal of ophthalmology, , Volume: 51, Issue:2

Evaluating the effects of acacetin versus a low dose of cisplatin drug on male reproductive system and kidney in mice: With emphasis on inflammation process.
Andrologia, , Volume: 52, Issue:1, 2020

A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci.
PloS one, , Volume: 7, Issue:11, 2012

Saliva--a pivotal player in the pathogenesis of oropharyngeal cancer.
British journal of cancer, , Jul-05, Volume: 91, Issue:1, 2004

Influenza Virus Infection Increases Host Susceptibility To Secondary Infection with Pseudomonas aeruginosa, and This Is Attributed To Neutrophil Dysfunction through Reduced Myeloperoxidase Activity.
Microbiology spectrum, , 02-14, Volume: 11, Issue:1, 2023

C5a receptor1 inhibition alleviates influenza virus-induced acute lung injury.
International immunopharmacology, , Volume: 59, 2018

Influenza virus infection causes neutrophil dysfunction through reduced G-CSF production and an increased risk of secondary bacteria infection in the lung.
Virology, , Volume: 499, 2016

Plasminogen activator inhibitor-1 in cigarette smoke exposure and influenza A virus infection-induced lung injury.
PloS one, , Volume: 10, Issue:5, 2015

N-acetyl-l-cystine (NAC) protects against H9N2 swine influenza virus-induced acute lung injury.
International immunopharmacology, , Volume: 22, Issue:1, 2014

Immunomorphologic manifestations in mice liver infected with influenza A/H5N1, A/goose/Krasnoozerskoye/627/05 strain.
Clinical & developmental immunology, , Volume: 2013, 2013

Contribution of neutrophil-derived myeloperoxidase in the early phase of fulminant acute respiratory distress syndrome induced by influenza virus infection.
Microbiology and immunology, , Volume: 56, Issue:3, 2012

Structural and functional changes in pulmonary macrophages and lungs of mice infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05.
Bulletin of experimental biology and medicine, , Volume: 153, Issue:2, 2012

Doxycycline treatment attenuates acute lung injury in mice infected with virulent influenza H3N2 virus: involvement of matrix metalloproteinases.
Experimental and molecular pathology, , Volume: 92, Issue:3, 2012

Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis.
The American journal of pathology, , Volume: 179, Issue:1, 2011

Expression of myeloperoxidase in swine influenza virus (SIV)-infected neutrophils in lungs from pigs experimentally infected with SIV subtype H1N2.
Veterinary research communications, , Volume: 35, Issue:7, 2011

MCP-1 antibody treatment enhances damage and impedes repair of the alveolar epithelium in influenza pneumonitis.
American journal of respiratory cell and molecular biology, , Volume: 42, Issue:6, 2010

Two-dimensional gel electrophoresis analysis in simultaneous influenza pneumonia and bacterial infection in mice.
Clinical and experimental immunology, , Volume: 152, Issue:2, 2008

Cigarette smoke impacts immune inflammatory responses to influenza in mice.
American journal of respiratory and critical care medicine, , Dec-15, Volume: 174, Issue:12, 2006

Acute infection with influenza virus enhances susceptibility to fatal pneumonia following Streptococcus pneumoniae infection in mice with chronic pulmonary colonization with Pseudomonas aeruginosa.
Clinical and experimental immunology, , Volume: 137, Issue:1, 2004

Absence of SP-A modulates innate and adaptive defense responses to pulmonary influenza infection.
American journal of physiology. Lung cellular and molecular physiology, , Volume: 282, Issue:3, 2002

Surfactant protein D enhances clearance of influenza A virus from the lung in vivo.
Journal of immunology (Baltimore, Md. : 1950), , Nov-15, Volume: 167, Issue:10, 2001

The effect of garlic extract, applied as such or in association with NaF, on experimental influenza in mice.
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[Mechanisms of the protective action of plant preparation erakond in influenza].
Zhurnal mikrobiologii, epidemiologii i immunobiologii, , Issue:1

[The effects of aqueous extracts of Raphanus niger on an experimental influenza infection in mice and on the enzyme polymorphism in lung tissue extracts].
Revue roumaine de virologie (Bucharest, Romania : 1990), , Volume: 41, Issue:2

Mocetinostat activates Krüppel-like factor 4 and protects against tissue destruction and inflammation in osteoarthritis.
JCI insight, , 09-08, Volume: 8, Issue:17, 2023

Could myeloperoxidase represent a useful biomarker for erosive osteoarthritis of the hand?
Scandinavian journal of rheumatology, , Volume: 47, Issue:6, 2018

A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis.
BMC complementary and alternative medicine, , Nov-22, Volume: 17, Issue:1, 2017

[no title available]
Applied physics. B, Lasers and optics, , Volume: 122, Issue:12, 2016

Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial.
BMC complementary and alternative medicine, , May-17, Volume: 14, 2014

Evaluation of biomarkers for osteoarthritis caused by fragmented medial coronoid process in dogs.
Research in veterinary science, , Volume: 96, Issue:3, 2014

Temporomandibular joint arthritis as an initial presentation of acute myeloid leukemia with myelodysplasia-related changes: a report of an unusual case.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, , Volume: 72, Issue:9, 2014

Coll2-1, Coll2-1NO2 and myeloperoxidase serum levels in erosive and non-erosive osteoarthritis of the hands.
Osteoarthritis and cartilage, , Volume: 20, Issue:6, 2012

Measurement of equine myeloperoxidase (MPO) activity in synovial fluid by a modified MPO assay and evaluation of joint diseases - an initial case study.
Research in veterinary science, , Volume: 84, Issue:3, 2008

Mud bath therapy influences nitric oxide, myeloperoxidase and glutathione peroxidase serum levels in arthritic patients.
International journal of clinical pharmacology research, , Volume: 20, Issue:3-4, 2000

Interleukin-8, interleukin-10, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression levels are higher in synovial tissue from patients with rheumatoid arthritis than in osteoarthritis.
Scandinavian journal of immunology, , Volume: 50, Issue:2, 1999

[The diagnostic information value of determining the cytochemical properties of the neutrophils from the blood and synovial fluid of patients with rheumatoid arthritis and osteoarthrosis deformans].
Terapevticheskii arkhiv, , Volume: 62, Issue:5, 1990

The response of human peripheral blood mononuclear phagocytes to rheumatoid arthritis.
Journal of leukocyte biology, , Volume: 37, Issue:2, 1985

Osteomyelitis-related glomerulonephritis with myeloperoxidase-antineutrophil cytoplasmic antibody positivity.
Pediatrics international : official journal of the Japan Pediatric Society, , Volume: 62, Issue:2, 2020

Whole-genome comparison of high and low virulent Staphylococcus aureus isolates inducing implant-associated bone infections.
International journal of medical microbiology : IJMM, , Volume: 308, Issue:5, 2018

Hyperbaric oxygen therapy in a mouse model of implant-associated osteomyelitis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, , Volume: 30, Issue:2, 2012

Myeloperoxidase secretion during phagocytosis: a case of a patient with impaired bactericidal activity.
Journal of clinical & laboratory immunology, , Volume: 27, Issue:2, 1988

Myeloperoxidase deficiency with extensive candidal osteomyelitis of the base of the skull.
Pediatrics, , Volume: 80, Issue:6, 1987

[Functional activity of blood neutrophilic granulocytes in acute odontogenic inflammatory diseases].
Laboratornoe delo, , Issue:4, 1983

An evaluation of the phagocytic cells in the ia (osteopetrotic) rat: oxidative metabolism in monocytes and macrophages.
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Patterns of cytokine release and evolution of remote organs from proximal femur fracture in COPD rats.
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A new assay for antiphlogistic activity: zymosan-induced mouse ear inflammation.
Agents and actions, , Volume: 39, Issue:3-4, 1993

Antimicrobial therapy for nontuberculous mycobacterial pulmonary disease improved hearing loss and normalized myeloperoxidase-anti-neutrophil cytoplasmic antibody level: A case report.
Modern rheumatology case reports, , 01-03, Volume: 7, Issue:1, 2023

Otitis media with ANCA-associated vasculitis: A retrospective study of 30 patients.
Modern rheumatology, , Aug-20, Volume: 32, Issue:5, 2022

The association between ear involvement and clinical features and prognosis in ANCA-associated vasculitis.
Auris, nasus, larynx, , Volume: 48, Issue:5, 2021

The treatment outcomes of rituximab for intractable otitis media with ANCA-associated vasculitis.
Auris, nasus, larynx, , Volume: 46, Issue:1, 2019

Evaluation of oxidative stress and antioxidants effect on turning process acute otitis media to chronic otitis media with effusion.
Nigerian journal of clinical practice, , Volume: 22, Issue:3, 2019

The Diagnostic and Clinical Utility of the Myeloperoxidase-DNA Complex as a Biomarker in Otitis Media With Antineutrophil Cytoplasmic Antibody-associated Vasculitis.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, , Volume: 40, Issue:2, 2019

Clinical features and treatment outcomes of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV): A retrospective analysis of 235 patients from a nationwide survey in Japan.
Modern rheumatology, , Volume: 27, Issue:1, 2017

The critical role of myeloperoxidase in Streptococcus pneumoniae clearance and tissue damage during mouse acute otitis media.
Innate immunity, , Volume: 23, Issue:3, 2017

Interleukin-17A Aggravates Middle Ear Injury Induced by Streptococcus pneumoniae through the p38 Mitogen-Activated Protein Kinase Signaling Pathway.
Infection and immunity, , Volume: 85, Issue:10, 2017

Otitis Media with ANCA-associated Vasculitis: A New Concept and the Associated Criteria.
Internal medicine (Tokyo, Japan), , Dec-15, Volume: 56, Issue:24, 2017

Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Positive Otitis Media and Rhinosinusitis With Pathological Features of Immunoglobulin G4-Related Disease: A Case Report.
The Annals of otology, rhinology, and laryngology, , Volume: 125, Issue:6, 2016

Characteristics of MPO-ANCA-positive granulomatosis with polyangiitis: a retrospective multi-center study in Japan.
Rheumatology international, , Volume: 35, Issue:3, 2015

Four cases of MPO-ANCA-positive vasculitis with otitis media, and review of the literature.
Modern rheumatology, , Volume: 23, Issue:3, 2013

Serum myeloperoxidase activity, total antioxidant capacity and nitric oxide levels in patients with chronic otitis media.
The Journal of membrane biology, , Volume: 246, Issue:7, 2013

Bilateral facial nerve palsy due to otitis media associated with myeloperoxidase-antineutrophil cytoplasmic antibody.
The American journal of the medical sciences, , Volume: 346, Issue:3, 2013

Otolaryngologic manifestations of antineutrophil cytoplasmic antibody-associated vasculitis.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, , Volume: 146, Issue:1, 2012

[Case of MPO-ANCA-positive Wegener's granulomatosis with hepatitis C virus infection].
Nihon Jinzo Gakkai shi, , Volume: 53, Issue:7, 2011

[Two cases of MPO-ANCA-positive otitis media associated with facial palsy].
Nihon Jibiinkoka Gakkai kaiho, , Volume: 113, Issue:2, 2010

Expression of myeloperoxidase and cochlear dysfunction in the lipopolysaccharide-treated guinea pig.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, , Volume: 258, Issue:4, 2001

Effect of WEB 2170 BS, platelet activating factor receptor inhibitor, in the guinea pig model of middle ear inflammation.
The Annals of otology, rhinology, and laryngology, , Volume: 109, Issue:6, 2000

Experimental otitis media induced by nonviable Moraxella catarrhalis in the guinea pig model.
Auris, nasus, larynx, , Volume: 24, Issue:3, 1997

Levels of eosinophil cationic protein and myeloperoxidase from chronic middle ear effusion in patients with allergy and/or acute infection.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, , Volume: 114, Issue:4, 1996

Early inflammatory changes of the Haemophilus influenzae-induced experimental otitis media.
Auris, nasus, larynx, , Volume: 22, Issue:2, 1995

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The diterpene from Sphagneticola trilobata (L.) Pruski, kaurenoic acid, reduces lipopolysaccharide-induced peritonitis and pain in mice.
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Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress.
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Sida tuberculata reduces oxidative stress and pain caused by the knee osteoarthritis.
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N-acetylcysteine a possible protector against indomethacin-induced peptic ulcer: crosstalk between antioxidant, anti-inflammatory, and antiapoptotic mechanisms.
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Omega-3 fatty acids are able to modulate the painful symptoms associated to cyclophosphamide-induced-hemorrhagic cystitis in mice.
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Superoxide anion-induced pain and inflammation depends on TNFα/TNFR1 signaling in mice.
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Pelvic organ cross-sensitization to enhance bladder and urethral pain behaviors in rats with experimental colitis.
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Bosentan, a mixed endothelin receptor antagonist, inhibits superoxide anion-induced pain and inflammation in mice.
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Carvacryl acetate, a derivative of carvacrol, reduces nociceptive and inflammatory response in mice.
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Polysaccharide isolated from Agardhiella ramosissima: chemical structure and anti-inflammation activity.
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Sulfated polysaccharides isolated from the green seaweed Caulerpa racemosa plays antinociceptive and anti-inflammatory activities in a way dependent on HO-1 pathway activation.
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Inhibition of inducible nitric oxide synthase-derived nitric oxide as a therapeutical target for acute pancreatitis induced by secretory phospholipase A2.
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Cyane-carvone, a synthetic derivative of carvone, inhibits inflammatory response by reducing cytokine production and oxidative stress and shows antinociceptive effect in mice.
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TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis.
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Antihypernociceptive activity of anethole in experimental inflammatory pain.
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Valproic acid: an anticonvulsant drug with potent antinociceptive and anti-inflammatory properties.
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Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors.
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Antihyperalgesic effects of myrsinoic acid B in pain-like behavior induced by inflammatory and neuropathic pain models in mice.
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Aleurites moluccana and its main active ingredient, the flavonoid 2″-O-rhamnosylswertisin, have promising antinociceptive effects in experimental models of hypersensitivity in mice.
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Ameliorative effect of caffeic acid against inflammatory pain in rodents.
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Evaluation of anti-inflammatory and antinociceptive effects of D-002 (beeswax alcohols).
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Anti-inflammatory properties of doxycycline and minocycline in experimental models: an in vivo and in vitro comparative study.
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Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation.
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Microscopic polyangiitis initiated with liver dysfunction, calf pain and fever of unknown origin.
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G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia.
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Participation of peripheral tachykinin NK1 receptors in the carrageenan-induced inflammation of the rat temporomandibular joint.
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Phenyl N-t-butylnitrone, a reactive oxygen species scavenger, reduces zymosan-induced visceral pain in rats.
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Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production.
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Anti-hypernociceptive properties of agmatine in persistent inflammatory and neuropathic models of pain in mice.
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Relevance of tumour necrosis factor-alpha for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw.
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Antinociceptive and anti-inflammatory effect of the aqueous extract from leaves of Pimenta racemosa var. ozua (Mirtaceae).
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Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain.
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Visceral hypersensitivity and altered colonic motility after subsidence of inflammation in a rat model of colitis.
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Pregabalin (CI-1008) inhibits the trinitrobenzene sulfonic acid-induced chronic colonic allodynia in the rat.
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Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
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MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma.
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A Nanozyme with Photo-Enhanced Dual Enzyme-Like Activities for Deep Pancreatic Cancer Therapy.
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Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma.
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Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.
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Augmentation of systemic blood pressure during spinal cord ischemia to prevent postoperative paraplegia after aortic surgery in a rabbit model.
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NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease.
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Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype.
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In Situ Peroxidase Labeling and Mass Spectrometry of Alpha-Synuclein in Rat Cortical Neurons.
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Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson's disease and in the hMPO-α-synuclein-A53T mouse model, correlating with increased nitration and aggregation of α-synuclein and exacerbation of motor impairment.
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Myeloperoxidase-immunoreactive cells are significantly increased in brain areas affected by neurodegeneration in Parkinson's and Alzheimer's disease.
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δ-Aminolevulinate Dehydratase Activity is Stimulated in a MPTP Mouse Model of Parkinson's Disease: Correlation with Myeloperoxidase Activity.
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Iron and Oxidative Stress in Parkinson's Disease: An Observational Study of Injury Biomarkers.
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Hypochlorite converts cysteinyl-dopamine into a cytotoxic product: A possible factor in Parkinson's Disease.
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DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase.
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Dietary chelators as antioxidant enzyme mimetics: implications for dietary intervention in neurodegenerative diseases.
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Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice.
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The cytotoxic activity of lactoperoxidase: enhancement and inhibition by neuroactive compounds.
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Brain iron deposition and the free radical-mitochondrial theory of ageing.
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Paroxetine prevents loss of nigrostriatal dopaminergic neurons by inhibiting brain inflammation and oxidative stress in an experimental model of Parkinson's disease.
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Acute myeloid leukemia mimicking parotid tumor: importance of peripheral smear.
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A critical role for neutrophil elastase in experimental bullous pemphigoid.
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Increased tryptase and myeloperoxidase levels in blister fluids of patients with bullous pemphigoid: correlations with cytokines, adhesion molecules and anti-basement membrane zone antibodies.
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The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo.
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The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA-/VacA- H. pylori.
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Prophylactic effect of egualen sodium, a stable azulene derivative, on gastrointestinal damage induced by ischemia/reperfusion, double antiplatelet therapy and loxoprofen in rats.
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Reduced small-intestinal injury induced by indomethacin in interleukin-17A-deficient mice.
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Urocortin prevents indomethacin-induced small intestinal lesions in rats through activation of CRF2 receptors.
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Antisecretory, antioxidative and antiapoptotic effects of montelukast on pyloric ligation and water immersion stress induced peptic ulcer in rat.
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Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a NO/cGMP-dependent mechanism.
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CV-11974, angiotensin II type I receptor antagonist, reduces the severity of indomethacin-induced rat enteritis.
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Lactobacillus rhamnosus GG exacerbates intestinal ulceration in a model of indomethacin-induced enteropathy.
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Bromophenacyl bromide, a phospholipase A2 inhibitor attenuates chemically induced gastroduodenal ulcers in rats.
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Melatonin protects against gastric ulceration and increases the efficacy of ranitidine and omeprazole in reducing gastric damage.
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Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues.
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Myeloperoxidase in the pericardial fluid improves the performance of prediction rules for postoperative atrial fibrillation.
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[no title available]
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Effects of thyroid hormone supplementation on anastomotic healing after segmental colonic resection.
The Journal of surgical research, , Volume: 176, Issue:2, 2012

Long-term results of ablation with antireflux surgery for Barrett's esophagus: a clinical and molecular biologic study.
Surgical endoscopy, , Volume: 26, Issue:7, 2012

Dietary ω3 fatty acids modulate the substrate for post-operative atrial fibrillation in a canine cardiac surgery model.
Cardiovascular research, , Mar-01, Volume: 89, Issue:4, 2011

Reversible surgical model of biliary inflammation and obstructive jaundice in mice.
The Journal of surgical research, , Volume: 164, Issue:2, 2010

GLP-2 receptor agonism ameliorates inflammation and gastrointestinal stasis in murine postoperative ileus.
The Journal of pharmacology and experimental therapeutics, , Volume: 333, Issue:2, 2010

Ischemic postconditioning modified renal oxidative stress and lipid peroxidation caused by ischemic reperfusion injury in rats.
Transplantation proceedings, , Volume: 41, Issue:9, 2009

Recipient genetic determinants of inflammatory process and nonstandard atherosclerosis risk factors affect kidney graft function early posttransplantation.
Transplantation proceedings, , Volume: 41, Issue:8, 2009

The effects of the Pringle maneuver on the pancreas: can octreotide be protective?
JOP : Journal of the pancreas, , May-18, Volume: 10, Issue:3, 2009

Tezosentan reduces the renal injury induced by abdominal aortic ischemia-reperfusion in rats.
The Journal of surgical research, , Volume: 157, Issue:1, 2009

Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents.
Brain research, , Jun-18, Volume: 1215, 2008

Exogenous melatonin ameliorates hepatic injury in a rat cardiopulmonary bypass model.
European journal of pharmacology, , Feb-12, Volume: 580, Issue:3, 2008

Priming donor lungs with thioredoxin-1 attenuates acute allograft injury in a rat model of lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, , Volume: 27, Issue:10, 2008

Effects of a membrane-permeable radical scavenger, Tempol, on healing of colonic anastomoses in the cecal ligation and puncture model of polymicrobial sepsis in rats.
American journal of surgery, , Volume: 193, Issue:6, 2007

Induction of heme oxygenase-1 improves impaired intestinal transit after burn injury.
Surgery, , Volume: 141, Issue:3, 2007

Histochemical alterations in one lung ventilation.
The Journal of surgical research, , Volume: 137, Issue:1, 2007

Pancreatic cellular injury after cardiac surgery with cardiopulmonary bypass: frequency, time course and risk factors.
Shock (Augusta, Ga.), , Volume: 27, Issue:5, 2007

Total liquid ventilation reduces lung injury in piglets after cardiopulmonary bypass.
The Annals of thoracic surgery, , Volume: 82, Issue:1, 2006

A single intraperitoneal dose of carbon monoxide-saturated ringer's lactate solution ameliorates postoperative ileus in mice.
The Journal of pharmacology and experimental therapeutics, , Volume: 319, Issue:3, 2006

The ICAM-1 antisense oligonucleotide ISIS-3082 prevents the development of postoperative ileus in mice.
British journal of pharmacology, , Volume: 146, Issue:2, 2005

The effect of anti-inflammatory properties of mycophenolate mofetil on the development of lung reperfusion injury.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, , Volume: 24, Issue:12, 2005

[Production of active oxygen by neutrophils in patients with cancer of the esophagus and stomach before and after surgical interventions].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], , Volume: 50, Issue:4, 2005

Inflammation of atrium after cardiac surgery is associated with inhomogeneity of atrial conduction and atrial fibrillation.
Circulation, , Jun-07, Volume: 111, Issue:22, 2005

Surgical manipulation of the intestine and distant organ damage-protection by oral glutamine supplementation.
Surgery, , Volume: 137, Issue:1, 2005

Overexpression of human copper/zinc superoxide dismutase (SOD1) suppresses ischemia-reperfusion injury and subsequent development of graft coronary artery disease in murine cardiac grafts.
Circulation, , Sep-14, Volume: 110, Issue:11 Suppl 1, 2004

Hydrogen peroxide derived from intestine through the mesenteric lymph induces lung edema after surgical stress.
Shock (Augusta, Ga.), , Volume: 21, Issue:2, 2004

Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts.
Circulation, , Sep-14, Volume: 110, Issue:11 Suppl 1, 2004

Iohexol-induced neutrophil myeloperoxidase release and activation upon contact with vascular stent-graft material: a mechanism contributing to the postimplantation syndrome?
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, , Volume: 10, Issue:5, 2003

Inhaled carbon monoxide suppresses the development of postoperative ileus in the murine small intestine.
Gastroenterology, , Volume: 124, Issue:2, 2003

Myocardial metabolism on off-pump surgery; a randomized study of 50 cases.
Scandinavian cardiovascular journal : SCJ, , Volume: 37, Issue:4, 2003

Bacterial antigen-induced release of white cell- and platelet-derived bioactive substances in vitro.
International journal of gastrointestinal cancer, , Volume: 31, Issue:1-3, 2002

[Cellular injury associated with extracorporeal circulation].
Annales de cardiologie et d'angeiologie, , Volume: 51, Issue:1, 2002

A randomized study to evaluate the effect of a perioperative infusion of dopexamine on colonic mucosal ischemia after aortic surgery.
Journal of vascular surgery, , Volume: 33, Issue:4, 2001

The side-effects of cardiopulmonary bypass on the lungs: changes in bronchoalveolar lavage fluids.
Perfusion, , Volume: 16, Issue:2, 2001

Attenuation of lung reperfusion injury after transplantation using an inhibitor of nuclear factor-kappaB.
American journal of physiology. Lung cellular and molecular physiology, , Volume: 279, Issue:3, 2000

No benefit of reduced heparinization in thoracic aortic operation with heparin-coated bypass circuits.
The Annals of thoracic surgery, , Volume: 69, Issue:3, 2000

Prestorage leukofiltration of whole blood and SAGM blood prevents extracellular bioactive substance accumulation.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 48, Issue:7, 1999

Reduced neutrophil infiltration protects against lung reperfusion injury after transplantation.
The Annals of thoracic surgery, , Volume: 67, Issue:5, 1999

Biphasic response to gut manipulation and temporal correlation of cellular infiltrates and muscle dysfunction in rat.
Surgery, , Volume: 126, Issue:3, 1999

Persistent high BAL fluid granulocyte activation marker levels as early indicators of bronchiolitis obliterans after lung transplant.
The European respiratory journal, , Volume: 14, Issue:5, 1999

Postoperative lung injury and oxidative damage in patients undergoing pulmonary resection.
The European respiratory journal, , Volume: 11, Issue:5, 1998

Myeloperoxidase in urine: a new marker for distinction between rejection and urinary tract infection after renal transplantation.
Transplantation proceedings, , Volume: 29, Issue:7, 1997

Effects of heparin coating of cardiopulmonary bypass circuits on in vitro oxygen free radical production during coronary bypass surgery.
Artificial organs, , Volume: 20, Issue:9, 1996

Allopurinol reduces the severity of peritoneal adhesions in mice.
Journal of pediatric surgery, , Volume: 30, Issue:4, 1995

Administration of prostaglandin E1 after lung transplantation improves early graft function.
The Annals of thoracic surgery, , Volume: 58, Issue:3, 1994

Inhibition of platelet adhesion during cardiopulmonary bypass reduces postoperative bleeding.
Circulation, , Volume: 90, Issue:5 Pt 2, 1994

Impaired neutrophil bactericidal activity correlates with the infection occurring after surgery for esophageal cancer.
Journal of surgical oncology, , Volume: 51, Issue:3, 1992

Neutrophil-dependent decrease in early wound margin strength.
Archives of surgery (Chicago, Ill. : 1960), , Volume: 126, Issue:11, 1991

Granulocyte chemiluminescence in patients with postoperative infections.
Archives of surgery (Chicago, Ill. : 1960), , Volume: 123, Issue:1, 1988

Leukocyte lysosomal function in sepsis.
Surgery, gynecology & obstetrics, , Volume: 159, Issue:5, 1984

Colonic anastomotic healing after preoperative chemo-radiotherapy in rat.
Radiation medicine, , Volume: 17, Issue:2

Octreotide prevents postoperative adhesion formation by suppressing peritoneal myeloperoxidase activity.
Hepato-gastroenterology, , Volume: 47, Issue:34

Neutrophil count is a useful marker to predict the severity of preeclampsia.
Clinical and experimental hypertension (New York, N.Y. : 1993), , May-19, Volume: 44, Issue:4, 2022

Placental endothelial nitric oxide synthase expression and role of oxidative stress in susceptibility to preeclampsia in Pakistani women.
Molecular genetics & genomic medicine, , Volume: 8, Issue:1, 2020

Both "canonical" and "immunological" preeclampsia subtypes demonstrate changes in placental immune cell composition.
Placenta, , Volume: 83, 2019

Increased Neutrophil Activation and Plasma DNA Levels in Patients with Pre-Eclampsia.
Thrombosis and haemostasis, , Volume: 118, Issue:12, 2018

Cardiac myeloperoxidase activity is elevated in hypertensive pregnant rats.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, , Volume: 37, Issue:6, 2017

Neutrophil release of myeloperoxidase in systemic vasculature of obese women may put them at risk for preeclampsia.
Reproductive sciences (Thousand Oaks, Calif.), , Volume: 22, Issue:3, 2015

CD4+ T cells are important mediators of oxidative stress that cause hypertension in response to placental ischemia.
Hypertension (Dallas, Tex. : 1979), , Volume: 64, Issue:5, 2014

Evaluation of the relationship between adenosine deaminase, myeloperoxidase, cholinesterase, preeclampsia severity, and neonatal outcomes.
Clinical and experimental hypertension (New York, N.Y. : 1993), , Volume: 34, Issue:7, 2012

Myeloperoxidase in the plasma and placenta of normal pregnant women and women with pregnancies complicated by preeclampsia and intrauterine growth restriction.
Placenta, , Volume: 33, Issue:4, 2012

Oxidative damage, inflammation, and Toll-like receptor 4 pathway are increased in preeclamptic patients: a case-control study.
Oxidative medicine and cellular longevity, , Volume: 2012, 2012

Genetic variation of myeloperoxidase gene contributes to preeclampsia: a preliminary association study in Turkish population.
Hypertension in pregnancy, , Volume: 30, Issue:4, 2011

A quantitative evaluation of total antioxidant status and oxidative stress markers in preeclampsia and gestational diabetic patients in 24-36 weeks of gestation.
Diabetes research and clinical practice, , Volume: 89, Issue:3, 2010

Increased myeloperoxidase in the placenta and circulation of women with preeclampsia.
Hypertension (Dallas, Tex. : 1979), , Volume: 52, Issue:2, 2008

Lethal candida sepsis associated with myeloperoxidase deficiency and pre-eclampsia.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, , Volume: 115, Issue:7, 2007

Serum advanced oxidation protein products, myeloperoxidase and ascorbic acid in pre-eclampsia and eclampsia.
The Australian & New Zealand journal of obstetrics & gynaecology, , Volume: 46, Issue:6, 2006

Oxidative stress-related gene polymorphism and the risk of preeclampsia.
European journal of obstetrics, gynecology, and reproductive biology, , Mar-01, Volume: 119, Issue:1, 2005

Pathological uterine perfusion in the second trimester is not associated with neutrophil activation.
Hypertension in pregnancy, , Volume: 22, Issue:3, 2003

Increased systemic activation of neutrophils but not complement in preeclampsia.
Obstetrics and gynecology, , Volume: 97, Issue:3, 2001

The use of platelet density and volume measurements to estimate the severity of pre-eclampsia.
European journal of clinical investigation, , Volume: 30, Issue:12, 2000

[Activity of acidic granulocyte phosphatase and myeloperoxidase among women with EPH gestosis].
Ginekologia polska, , Volume: 63, Issue:6, 1992

[Prognostic significance of thrombocyte metabolism in pregnancy].
Jugoslavenska ginekologija i perinatologija, , Volume: 28, Issue:5-6

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.
The Journal of clinical investigation, , Volume: 122, Issue:9, 2012

Myeloperoxidase-positive cell infiltration in colorectal carcinogenesis as indicator of colorectal cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , Volume: 17, Issue:9, 2008

Association of the polymorphisms of MTHFR C677T, VDR C352T, and MPO G463A with risk for esophageal squamous cell dysplasia and carcinoma.
Archives of medical research, , Volume: 39, Issue:6, 2008

Association of polymorphisms in myeloperoxidase and catalase genes with precancerous changes in the gastric mucosa of patients at inner-city hospitals in New York.
Oncology reports, , Volume: 18, Issue:1, 2007

Effect of inflammation on cyclooxygenase (COX)-2 expression in benign and malignant oesophageal cells.
Carcinogenesis, , Volume: 26, Issue:9, 2005

Suppressed apoptosis in the inflamed gastric mucosa of Helicobacter pylori-colonized iNOS-knockout mice.
Free radical biology & medicine, , Jun-15, Volume: 34, Issue:12, 2003

Enzymatic deficiencies of the immune system cells in patients with cancer of the larynx and other malignancies.
Auris, nasus, larynx, , Volume: 12, Issue:1, 1985

Knowledge of an inflammatory biomarker of cardiovascular risk leads to biomarker-based decreased risk in pre-diabetic and diabetic patients.
The Journal of international medical research, , Volume: 48, Issue:1, 2020

Myeloperoxidase, superoxide dismutase-3, cardiometabolic risk factors, and distal sensorimotor polyneuropathy: The KORA F4/FF4 study.
Diabetes/metabolism research and reviews, , Volume: 34, Issue:5, 2018

CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse.
Apoptosis : an international journal on programmed cell death, , Volume: 16, Issue:4, 2011

Association of myeloperoxidase with cardiovascular disease risk factors in prediabetic subjects.
Diabetes & metabolic syndrome, , Volume: 13, Issue:1

Assessment of oxidative stress and inflammation in prediabetes-A hospital based cross-sectional study.
Diabetes & metabolic syndrome, , Volume: 10, Issue:2 Suppl 1

Reperfusion of ischemic corporal tissue: physiologic and biochemical changes in an animal model of ischemic priapism.
Urology, , Volume: 62, Issue:4, 2003

Possible role of mucosal mast cells in the recovery process of colitis induced by dextran sulfate sodium in rats.
International immunopharmacology, , Volume: 3, Issue:4, 2003

Human neutrophil lipocalin is a unique marker of neutrophil inflammation in ulcerative colitis and proctitis.
Gut, , Volume: 50, Issue:4, 2002

Neutrophil and eosinophil granule proteins as markers of response to local prednisolone treatment in distal ulcerative colitis and proctitis.
The American journal of gastroenterology, , Volume: 96, Issue:4, 2001

Mucosal synthesis and release of prostaglandin E2 from activated eosinophils and macrophages in ulcerative colitis.
The American journal of gastroenterology, , Volume: 90, Issue:4, 1995

Protective effect of the tachykinin NK2 receptor antagonist nepadutant in acute rectocolitis induced by diluted acetic acid in guinea-pigs.
Neuropeptides, , Volume: 34, Issue:6, 2000

Effect of MEN 11467, a new tachykinin NK1 receptor antagonist, in acute rectocolitis induced by acetic acid in guinea-pigs.
European journal of pharmacology, , Jun-18, Volume: 374, Issue:2, 1999

Myeloperoxidase and Prostate volume: A preliminary study.
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie, , Volume: 28, Issue:10, 2018

Intriguing location of myeloperoxidase in the prostate: a preliminary immunohistochemical study.
The Prostate, , Volume: 72, Issue:5, 2012

Prepubertal exposure to compounds that increase prolactin secretion in the male rat: effects on the adult prostate.
Biology of reproduction, , Volume: 61, Issue:6, 1999

Brain Boron Level, DNA Content, and Myeloperoxidase Activity of Metformin-Treated Rats in Diabetes and Prostate Cancer Model.
Biological trace element research, , Volume: 200, Issue:3, 2022

Lysine 53 Acetylation of Cytochrome
Cells, , 04-03, Volume: 10, Issue:4, 2021

Proteomics-Metabolomics Combined Approach Identifies Peroxidasin as a Protector against Metabolic and Oxidative Stress in Prostate Cancer.
International journal of molecular sciences, , Jun-21, Volume: 20, Issue:12, 2019

A colorimetric paper sensor for citrate as biomarker for early stage detection of prostate cancer based on peroxidase-like activity of cysteine-capped gold nanoclusters.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, , Mar-05, Volume: 210, 2019

A Sample-to-Targeted Gene Analysis Biochip for Nanofluidic Manipulation of Solid-Phase Circulating Tumor Nucleic Acid Amplification in Liquid Biopsies.
ACS sensors, , 12-28, Volume: 3, Issue:12, 2018

Polymorphisms of eNOS, catalase, and myeloperoxidase genes in prostate cancer in Turkish men: preliminary results.
Genetics and molecular research : GMR, , Aug-19, Volume: 15, Issue:3, 2016

A portable chemiluminescence imaging immunoassay for simultaneous detection of different isoforms of prostate specific antigen in serum.
Biosensors & bioelectronics, , Jul-15, Volume: 81, 2016

[no title available]
Applied physics. B, Lasers and optics, , Volume: 122, Issue:12, 2016

Evaluation of prognostic significance of granulocyte-related factors in cancer patients undergoing personalized peptide vaccination.
Human vaccines & immunotherapeutics, , Volume: 11, Issue:12, 2015

[Association between the myeloperoxidase gene polymorphisms and the susceptibility to prostate cancer: a case-control study in a Chinese population].
Actas urologicas espanolas, , Volume: 37, Issue:2, 2013

Serum phospholipid fatty acids, genetic variation in myeloperoxidase, and prostate cancer risk in heavy smokers: a gene-nutrient interaction in the carotene and retinol efficacy trial.
American journal of epidemiology, , May-15, Volume: 177, Issue:10, 2013

Peroxidase-like activity of Fe3O4@carbon nanoparticles enhances ascorbic acid-induced oxidative stress and selective damage to PC-3 prostate cancer cells.
ACS applied materials & interfaces, , Dec-26, Volume: 5, Issue:24, 2013

Manganese superoxide dismutase Ile58Thr, catalase C-262T and myeloperoxidase G-463A gene polymorphisms in patients with prostate cancer: relation to advanced and metastatic disease.
BJU international, , Volume: 112, Issue:4, 2013

The association between polymorphisms in prooxidant or antioxidant enzymes (myeloperoxidase, SOD2, and CAT) and genes and prostate cancer risk in the Chinese population of Han nationality.
Clinical genitourinary cancer, , Volume: 10, Issue:4, 2012

Intriguing location of myeloperoxidase in the prostate: a preliminary immunohistochemical study.
The Prostate, , Volume: 72, Issue:5, 2012

Colorimetric platform for visual detection of cancer biomarker based on intrinsic peroxidase activity of graphene oxide.
Biosensors & bioelectronics, , May-15, Volume: 26, Issue:9, 2011

Genetic variation in myeloperoxidase modifies the association of serum α-tocopherol with aggressive prostate cancer among current smokers.
The Journal of nutrition, , Volume: 141, Issue:9, 2011

Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer.
Pharmacogenetics and genomics, , Volume: 21, Issue:10, 2011

Iron intake, oxidative stress-related genes (MnSOD and MPO) and prostate cancer risk in CARET cohort.
Carcinogenesis, , Volume: 29, Issue:5, 2008

[Case 8. Perspectives in 2007 for bladder pathology. Prostatic adenocarcinoma invading the bladder].
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Inactivation of anthracyclines by cellular peroxidase.
Cancer research, , Jul-15, Volume: 65, Issue:14, 2005

Expression of Lewis carbohydrate antigens in metastatic lesions from human prostatic carcinoma.
The Prostate, , Aug-01, Volume: 36, Issue:3, 1998

Spontaneous chemiluminescence of ETYA (5,8,11,14-eicosatetraynoic acid) is inhibited by catalase or peroxidase.
Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 51, Issue:4, 1994

Myeloperoxidase G-463A polymorphism and risk of lung and prostate cancer in a Turkish population.
Molecular medicine reports, , Volume: 4, Issue:1

Anti-MPO small-vessel vasculitis causing prostatis and nephritis.
Clinical and experimental nephrology, , Volume: 11, Issue:2, 2007

Chronic prostatitis/chronic pelvic pain pyndrome): seminal markers of inflammation.
World journal of urology, , Volume: 21, Issue:2, 2003

Prepubertal exposure to compounds that increase prolactin secretion in the male rat: effects on the adult prostate.
Biology of reproduction, , Volume: 61, Issue:6, 1999

Maternal exposure to atrazine during lactation suppresses suckling-induced prolactin release and results in prostatitis in the adult offspring.
Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 52, Issue:1, 1999

Increased Urinary Trimethylamine N-Oxide Following Cryptosporidium Infection and Protein Malnutrition Independent of Microbiome Effects.
The Journal of infectious diseases, , 07-01, Volume: 216, Issue:1, 2017

Assessment of myeloperoxidase and oxidative alpha1-antitrypsin in patients on hemodialysis.
Clinical journal of the American Society of Nephrology : CJASN, , Volume: 4, Issue:1, 2009

N-acetyl-L-glutamine, a liquid-stable source of glutamine, partially prevents changes in body weight and on intestinal immunity induced by protein energy malnutrition in pigs.
Digestive diseases and sciences, , Volume: 52, Issue:3, 2007

Innate lung defenses and compromised Pseudomonas aeruginosa clearance in the malnourished mouse model of respiratory infections in cystic fibrosis.
Infection and immunity, , Volume: 68, Issue:4, 2000

The effect of hypoprotein nutrition upon granular cationic proteins and myeloperoxidase and lactic dehydrogenase enzyme activities in rat peripheral blood granulocytes. Study I.
Acta medica Iugoslavica, , Volume: 40, Issue:1, 1986

Disorders of phagocyte function: biochemical aspects.
Progress in clinical and biological research, , Volume: 13, 1977

Cyclophosphamide-associated enteritis presenting with severe protein-losing enteropathy in granulomatosis with polyangiitis: A case report.
World journal of gastroenterology, , May-28, Volume: 27, Issue:20, 2021

Sex disparities in clinicopathological features and outcomes of patients with myeloperoxidase-ANCA-associated vasculitis: a retrospective study of 366 cases in a single Chinese center.
Clinical and experimental medicine, , Volume: 23, Issue:7, 2023

A case of intravascular large B-cell lymphoma with renal involvement presenting with elevated serum ANCA titers.
CEN case reports, , Volume: 10, Issue:1, 2021

Characterization of a Rat Model of Myeloperoxidase-Anti-Neutrophil Cytoplasmic Antibody-Associated Crescentic Glomerulonephritis.
Nephron, , Volume: 145, Issue:4, 2021

Sphingosine-1-phosphate receptor modulator FTY720 attenuates experimental myeloperoxidase-ANCA vasculitis in a T cell-dependent manner.
Clinical science (London, England : 1979), , 06-26, Volume: 134, Issue:12, 2020

Recognizing Central Nervous System Involvement as a Progressive Feature of Microscopic Polyangiitis: A Diagnostic Dilemma.
The American journal of medicine, , Volume: 132, Issue:9, 2019

Emergence of Smoldering ANCA-associated Glomerulonephritis during the Clinical Course of Mixed Connective Tissue Disease and Sjögren's Syndrome.
Internal medicine (Tokyo, Japan), , Jun-15, Volume: 57, Issue:12, 2018

Clinical and pathologic characteristics of pauci-immune anti-myeloperoxidase antibody associated glomerulonephritis with nephrotic range proteinuria.
Renal failure, , Volume: 40, Issue:1, 2018

ANCA-associated vasculitis in scleroderma: A renal perspective .
Clinical nephrology, , Volume: 90, Issue:6, 2018

Myeloperoxidase-antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis developed from ANCA negative renal limited vasculitis: A case report.
Medicine, , Volume: 96, Issue:51, 2017

ANCA and IgA glomerulonephritis all in one: prognosis and complications.
BMJ case reports, , Oct-09, Volume: 2017, 2017

Kidney transplantation for a patient with refractory childhood-onset ANCA-associated vasculitis.
Modern rheumatology, , Volume: 26, Issue:2, 2016

Clinical features of children with pulmonary microscopic polyangiitis: report of 9 cases.
PloS one, , Volume: 10, Issue:4, 2015

Successful Management of Lupus Nephritis with High Titers of Myeloperoxidase Anti-Neutrophil Cytoplasmic Antibodies Using Tacrolimus.
Internal medicine (Tokyo, Japan), , Volume: 54, Issue:22, 2015

Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats.
Naunyn-Schmiedeberg's archives of pharmacology, , Volume: 387, Issue:2, 2014

C5a receptor (CD88) blockade protects against MPO-ANCA GN.
Journal of the American Society of Nephrology : JASN, , Volume: 25, Issue:2, 2014

New markers: urine xanthine oxidase and myeloperoxidase in the early detection of urinary tract infection.
Disease markers, , Volume: 2014, 2014

ANCA associated glomerulonephritis in a patient with mixed connective tissue disease.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, , Volume: 39, Issue:2, 2014

Membranous glomerulonephritis associated with myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, , Jul-17, Volume: 32, Issue:4, 2012

Myeloperoxidase-antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis with rheumatoid arthritis: a comparison of patients without rheumatoid arthritis.
Clinical and experimental nephrology, , Volume: 14, Issue:4, 2010

Gender-specific differences in the urinary expression of aldosterone, IL-1α and IL-1β.
Biomarkers in medicine, , Volume: 4, Issue:6, 2010

Churg-Strauss syndrome: a retrospective study of 11 cases from a single center in Japan.
International journal of rheumatic diseases, , Volume: 13, Issue:3, 2010

Gastrointestinal sensitivity to soy and milk proteins in patients with IgA nephropathy.
Clinical nephrology, , Volume: 74, Issue:5, 2010

Endogenous myeloperoxidase promotes neutrophil-mediated renal injury, but attenuates T cell immunity inducing crescentic glomerulonephritis.
Journal of the American Society of Nephrology : JASN, , Volume: 18, Issue:3, 2007

A novel mouse model for MPO-ANCA-associated glomerulonephritis.
Microbiology and immunology, , Volume: 50, Issue:2, 2006

(-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors.
The Journal of pharmacy and pharmacology, , Volume: 56, Issue:2, 2004

Evaluation of prognostic factors for myeloperoxidase anti-neutrophil cytoplasmic antibody- (MPO-ANCA) associated glomerulonephritis.
Clinical nephrology, , Volume: 55, Issue:4, 2001

Clinicopathological study of myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.
Clinical nephrology, , Volume: 52, Issue:5, 1999

Expression of iNOS, eNOS, and peroxynitrite-modified proteins in experimental anti-myeloperoxidase associated crescentic glomerulonephritis.
Kidney international, , Volume: 53, Issue:2, 1998

Myeloperoxidase in urine: a new marker for distinction between rejection and urinary tract infection after renal transplantation.
Transplantation proceedings, , Volume: 29, Issue:7, 1997

Aggravation of rat nephrotoxic serum nephritis by anti-myeloperoxidase antibodies.
Kidney international, , Volume: 47, Issue:2, 1995

Polymorphonuclear leukocytes increase glomerular albumin permeability via hypohalous acid.
Kidney international, , Volume: 46, Issue:4, 1994

Attenuation of anti-Thy1 glomerulonephritis in the rat by anti-inflammatory platelet-inhibiting agents.
The American journal of pathology, , Volume: 142, Issue:2, 1993

Morphologic correlates of glomerular oxidant injury induced by the myeloperoxidase-hydrogen peroxide-halide system of the neutrophil.
Laboratory investigation; a journal of technical methods and pathology, , Volume: 58, Issue:3, 1988

New mechanism for glomerular injury. Myeloperoxidase-hydrogen peroxide-halide system.
The Journal of clinical investigation, , Volume: 79, Issue:5, 1987

ANCA-positive vasculitis: Clinical implications of ANCA types and titers.
Revista da Associacao Medica Brasileira (1992), , Volume: 62, Issue:5

[A rare tumor of the main biliary duct].
Annales de pathologie, , Volume: 30, Issue:6, 2010

Collared mice: a model to assess the effects of scratching.
Journal of dermatological science, , Volume: 57, Issue:1, 2010

Identification of a serum-derived promotor of granulocyte granule secretion: study on a patient with chronic pruritus.
Immunology, , Volume: 45, Issue:3, 1982

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Severe Pulmonary Embolism, Thrombosis of Lower Extremity, Unexpected Mild Renal Disorder in MPO-ANCA Associated Vasculitis: A Case Report.
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, , Dec-31, Volume: 36, Issue:4, 2021

Association of Pulmonary Hemorrhage, Positive Proteinase 3, and Urinary Red Blood Cell Casts With Venous Thromboembolism in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Arthritis & rheumatology (Hoboken, N.J.), , Volume: 71, Issue:11, 2019

Histological criteria for age determination of fatal venous thromboembolism.
International journal of legal medicine, , Volume: 132, Issue:3, 2018

Hypoxia-preconditioned mesenchymal stem cells ameliorate ischemia/reperfusion-induced lung injury.
PloS one, , Volume: 12, Issue:11, 2017

Proinflammatory events in right ventricular damage during pulmonary embolism: effects of treatment with ketorolac in rats.
Journal of cardiovascular pharmacology, , Volume: 54, Issue:3, 2009

[Changes in oxidative stress and hemostatic parameters in the course of thrombolytic therapy of pulmonary embolism].
Orvosi hetilap, , May-18, Volume: 149, Issue:20, 2008

Comparison of 8 biomarkers for prediction of right ventricular hypokinesis 6 months after submassive pulmonary embolism.
American heart journal, , Volume: 156, Issue:2, 2008

N-acetylcysteine attenuates acute lung injury induced by fat embolism.
Critical care medicine, , Volume: 36, Issue:2, 2008

Tandem measurement of D-dimer and myeloperoxidase or C-reactive protein to effectively screen for pulmonary embolism in the emergency department.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, , Volume: 15, Issue:9, 2008

Natural anticoagulants limit lipopolysaccharide-induced pulmonary coagulation but not inflammation.
The European respiratory journal, , Volume: 30, Issue:3, 2007

Evaluation of oxidative stress in the thrombolysis of pulmonary embolism.
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Exploring the Therapeutic Efficacy of Zingerone Nanoparticles in Treating Biofilm-Associated Pyelonephritis Caused by Pseudomonas aeruginosa in the Murine Model.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
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Sivelestat, a specific neutrophil elastase inhibitor, prevented phorbol myristate acetate-induced acute lung injury in conscious rabbits.
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Different effects of surfactant and inhaled nitric oxide in modulation of inflammatory injury in ventilated piglet lungs.
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Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters.
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Serum ECP and MPO are increased during exacerbations of chronic bronchitis with airway obstruction.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
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Neutrophil infiltration and activation in bronchiolitic airways are independent of viral etiology.
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Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody-associated vasculitis.
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Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactions.
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Promising Neutrophil-Associated Biomarkers in Lung Diseases of Patients with Antisynthetase Syndrome and Dermatomyositis.
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Immunological and pathological aspects of respiratory tract infection with Stenotrophomonas maltophilia in BALB/c mice.
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Effect of leukotoxin of Mannheimia haemolytica and LPS of E. coli on secretory response of bovine neutrophils in vitro.
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Assessment of neutrophil components as markers of lung injury in the course of bovine respiratory tract infections.
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Innate lung defenses and compromised Pseudomonas aeruginosa clearance in the malnourished mouse model of respiratory infections in cystic fibrosis.
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Role of nasal interleukin-8 in neutrophil recruitment and activation in children with virus-induced asthma.
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Neutrophil mediators, Pseudomonas, and pulmonary dysfunction in cystic fibrosis.
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Protective effects of Vitamin C against spinal cord injury-induced renal damage through suppression of NF-κB and proinflammatory cytokines.
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Increased lipid peroxide levels and myeloperoxidase activity in the vitreous of patients suffering from proliferative diabetic retinopathy.
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Platelet activation is caused not by aging but by atherosclerosis.
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Increased lipid peroxides and inflammatory parameters in the retina adjacent to choroidal melanoma.
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Expression of oxidative stress in metastatic retinoblastoma- a comparative study.
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Early Depletion of Neutrophils Reduces Retinal Inflammation and Neovascularization in Mice with Oxygen-Induced Retinopathy.
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Oleuropein suppresses oxidative, inflammatory, and apoptotic responses following glycerol-induced acute kidney injury in rats.
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Characterization of systemic and histologic injury after crush syndrome and intervals of reperfusion in a small animal model.
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Onset of acquired autoimmune hypothyroidism in infancy: a presentation of delayed gross-motor development and rhabdomyolysis.
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Pretreatment with aminophylline reduces release of Troponin I and neutrophil activation in the myocardium of patients undergoing cardioplegic arrest.
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Lactobacillus plantarum Restores Intestinal Permeability Disrupted by Salmonella Infection in Newly-hatched Chicks.
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Integrated traditional Chinese medicine alleviates sciatica while regulating gene expression in peripheral blood.
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Assessment of kidney involvement in systemic sclerosis: From scleroderma renal crisis to subclinical renal vasculopathy.
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Assessment of kidney involvement in systemic sclerosis: From scleroderma renal crisis to subclinical renal vasculopathy.
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Autoantibodies to proteinase 3 and myeloperoxidase in systemic sclerosis.
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Microscopic polyangiitis presenting as pulmonary-renal syndrome in a patient with long-standing diffuse cutaneous systemic sclerosis and antibodies to myeloperoxidase.
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MPO-ANCA-Positive crescentic glomerulonephritis: a distinct entity of scleroderma renal disease?
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Scleroderma, D-penicillamine treatment, and progressive renal failure associated with positive antimyeloperoxidase antineutrophil cytoplasmic antibodies.
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D-penicillamine-induced crescentic glomerulonephritis and antimyeloperoxidase antibodies in a patient with scleroderma. Case report and review of the literature.
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Autoantibodies to myeloperoxidase in systemic sclerosis.
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Myeloperoxidase-specific anti-neutrophil cytoplasmic autoantibodies -- related scleroderma renal crisis treated with double-filtration plasmapheresis.
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[A case of progressive systemic sclerosis with crescentic glomerulonephritis associated with myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) and anti-glomerular basement membrane antibody (anti-GBM Ab)].
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Hemophagocytosis associated with MPO-ANCA positive vasculitis in systemic sclerosis.
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[Analysis of DNM1L gene variant in a case of fatal encephalopathy caused by mitochondrial peroxidase division deficiency].
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The anticonvulsant effects of Ducrosia anethifolia (Boiss) essential oil are produced by its main component alpha-pinene in rats.
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Octreotide ameliorates inflammation and apoptosis in acute and kindled murine PTZ paradigms.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
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The role of resistin and myeloperoxidase in severe sepsis and septic shock: Results from the ALBIOS trial.
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A brief comment on the predictive value of myeloperoxidase-conjugated DNA level in patients with septic shock.
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Exosomes from patients with septic shock convey miRNAs related to inflammation and cell cycle regulation: new signaling pathways in sepsis?
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TAT-SNAP-23 treatment inhibits the priming of neutrophil functions contributing to shock and/or sepsis-induced extra-pulmonary acute lung injury.
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Protective effect of sanguinarine on LPS-induced endotoxic shock in mice and its effect on LPS-induced COX-2 expression and COX-2 associated PGE2 release from peritoneal macrophages.
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Creating a prosurvival phenotype through a histone deacetylase inhibitor in a lethal two-hit model.
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Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury.
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Mycophenolate mofetil has potent anti-inflammatory actions in a mouse model of acute lung injury.
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Heparin rescues sepsis-associated acute lung injury and lethality through the suppression of inflammatory responses.
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Scavenger receptor class a plays a central role in mediating mortality and the development of the pro-inflammatory phenotype in polymicrobial sepsis.
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Betulinic acid inhibits endotoxin-stimulated phosphorylation cascade and pro-inflammatory prostaglandin E(2) production in human peripheral blood mononuclear cells.
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The peroxynitrite catalyst WW-85 improves pulmonary function in ovine septic shock.
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Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis.
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Essential role of CCR2 in neutrophil tissue infiltration and multiple organ dysfunction in sepsis.
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Treatment with histone deacetylase inhibitor attenuates MAP kinase mediated liver injury in a lethal model of septic shock.
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Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation.
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Protective effect of suberoylanilide hydroxamic acid against LPS-induced septic shock in rodents.
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Paeoniflorin inhibits systemic inflammation and improves survival in experimental sepsis.
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Tezosentan attenuates organ injury and mesenteric blood flow decrease in endotoxemia and cecal ligation and puncture.
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Urocortin and adrenomedullin prevent lethal endotoxemia by down-regulating the inflammatory response.
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15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock.
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p53 is a suppressor of inflammatory response in mice.
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Analysis of the role of the PAC1 receptor in neutrophil recruitment, acute-phase response, and nitric oxide production in septic shock.
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Protective role of angiopoietin-1 in endotoxic shock.
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Treatment with a novel poly(ADP-ribose) glycohydrolase inhibitor reduces development of septic shock-like syndrome induced by zymosan in mice.
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Comparative study of glucocorticoids, cyclosporine A, and JTE-607 [(-)-Ethyl-N[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]-L-phenylalaninate dihydrochloride] in a mouse septic shock model.
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A potential role of hyperbaric oxygen exposure through intestinal nuclear factor-kappaB.
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Cardiac UCP2 expression and myocardial oxidative metabolism during acute septic shock in the rat.
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Therapeutic effect of propofol in the treatment of endotoxin-induced shock in rats.
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Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-kappaB and MAPK/ERK mechanisms.
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Inosine improves gut permeability and vascular reactivity in endotoxic shock.
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DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin.
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Resistance to endotoxin shock in transgenic mice overexpressing endothelial nitric oxide synthase.
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Pyrrolidine dithiocarbamate prevents I-kappaB degradation and reduces microvascular injury induced by lipopolysaccharide in multiple organs.
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Poly (ADP-ribose) synthetase activation mediates pulmonary microvascular and intestinal mucosal dysfunction in endotoxin shock.
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Protective effect of ciliary neurotrophic factor (CNTF) in a model of endotoxic shock: action mechanisms and role of CNTF receptor alpha.
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Attenuation of endotoxin-induced pathophysiology by a new potent PAF receptor antagonist.
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Microscopic polyangiitis accompanied by pleuritis as the only pulmonary manifestation of occupational silica exposure.
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Diagnostic and pathogenetic role of antineutrophil cytoplasmic autoantibodies.
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The mast cell: the comfortable third in recent CRS research.
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Effect of Local Corticosteroid Administration on CD8+CD25+Foxp3+ Tregs in Neutrophilic CRSwNP.
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Association between sinusitis and relapse and changes in the myeloperoxidase-antineutrophil cytoplasmic antibody in microscopic polyangiitis.
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The complexity of classifying ANCA-associated small-vessel vasculitis in actual clinical practice: data from a multicenter retrospective survey.
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Role of local allergic inflammation and Staphylococcus aureus enterotoxins in Chinese patients with chronic rhinosinusitis with nasal polyps.
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Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Positive Otitis Media and Rhinosinusitis With Pathological Features of Immunoglobulin G4-Related Disease: A Case Report.
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Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers.
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Staphylococcus epidermidis and biofilm-associated neutrophils in chronic rhinosinusitis. A pilot study.
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A case of sinobronchial syndrome complicated with myeloperoxidase antineutrophil cytoplasmic antibody associated vasculitis: review of the literature.
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Immunopathology of chronic rhinosinusitis in young children.
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Local IgE and inflammation in chronic rhinosinusitis of asthmatics and non-asthmatics.
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Can antineutrophil cytoplasmic antibody positivity at diagnosis predict the poor outcomes of Sjögren's syndrome?
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Emergence of Smoldering ANCA-associated Glomerulonephritis during the Clinical Course of Mixed Connective Tissue Disease and Sjögren's Syndrome.
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Dual anti-neutrophil cytoplasmic antibody-related pauci-immune crescentic glomerulonephritis in a patient with Sjögren's syndrome.
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Pulmonary hyalinizing granuloma associated with Sjögren syndrome and ANCA MPO vasculitis.
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Salivary: flow and proteins of the innate and adaptive immunity in the limited and diffused systemic sclerosis.
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Increased levels of serum myeloperoxidase in patients with active rheumatoid arthritis.
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Mixed connective tissue disease associated with MPO-ANCA-positive polyangiitis.
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Development and evaluation of a new ELISA for the detection and quantification of antierythropoietin antibodies in human sera.
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Autoimmune thyroiditis and anti-thyroid antibodies in primary Sjogren's syndrome: a case-control study.
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Pulmonary fibrosis in myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitides.
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Impaired neurotransmitter release from lacrimal and salivary gland nerves of a murine model of Sjögren's syndrome.
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Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases.
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Investigating the histopathological findings and immunolocalization of rickettsialpox infection in skin biopsies: A case series and review of the literature.
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The complexity of classifying ANCA-associated small-vessel vasculitis in actual clinical practice: data from a multicenter retrospective survey.
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Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody-associated vasculitis.
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Fever, lipodystrophy and cutaneous lesions.
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Anti-TWEAK monoclonal antibodies reduce vascular damage and leucocyte infiltration in a mouse model of cutaneous reverse passive Arthus reaction.
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Histologic and Immunohistochemical Features of the Skin Lesions in CANDLE Syndrome.
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Topical application of the adenosine A2A receptor agonist CGS-21680 prevents phorbol-induced epidermal hyperplasia and inflammation in mice.
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Oral diseases, , Volume: 14, Issue:8, 2008

Treatment of aphthous patients by enhancement of the salivary peroxidase system.
Journal of oral pathology, , Volume: 16, Issue:8, 1987

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European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, , Volume: 31, Issue:6, 2012

Myeloperoxidase deficiency associated with atypical oral candidiasis: A clinical report.
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Modulatory effects of longan seed powder on growth performance, immune response, and immune-antioxidant related gene expression in Nile tilapia (Oreochromis niloticus) raised under biofloc system.
Fish & shellfish immunology, , Volume: 123, 2022

Immune response and protective efficacy of two new adjuvants, Montanide™ ISA 763B VG and Montanide™ GEL02, administered with a Streptococcus agalactiae ghost vaccine in Nile tilapia (Oreochromis niloticus).
Fish & shellfish immunology, , Volume: 116, 2021

Dietary inclusion of watermelon rind powder and Lactobacillus plantarum: Effects on Nile tilapia's growth, skin mucus and serum immunities, and disease resistance.
Fish & shellfish immunology, , Volume: 116, 2021

Interleukin-17A Aggravates Middle Ear Injury Induced by Streptococcus pneumoniae through the p38 Mitogen-Activated Protein Kinase Signaling Pathway.
Infection and immunity, , Volume: 85, Issue:10, 2017

A prebiotic effect of Ecklonia cava on the growth and mortality of olive flounder infected with pathogenic bacteria.
Fish & shellfish immunology, , Volume: 51, 2016

LL-37 Triggers Formation of Streptococcus pyogenes Extracellular Vesicle-Like Structures with Immune Stimulatory Properties.
Journal of innate immunity, , Volume: 8, Issue:3, 2016

Pediatric case of crescentic post-streptococcal glomerulonephritis with myeloperoxidase anti-neutrophil cytoplasmic antibody.
Clinical nephrology, , Volume: 83, Issue:4, 2015

Identification of a myeloperoxidase-like ortholog from rock bream (Oplegnathus fasciatus), deciphering its transcriptional responses to induced pathogen stress.
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Prolonged infections associated with antineutrophil cytoplasmic antibodies specific to proteinase 3 and myeloperoxidase: diagnostic and therapeutic challenge.
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Promising Biomarkers of Environmental Enteric Dysfunction: A Prospective Cohort study in Pakistani Children.
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A case of sinobronchial syndrome complicated with myeloperoxidase antineutrophil cytoplasmic antibody associated vasculitis: review of the literature.
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Usefulness of baseline plasma myeloperoxidase levels as an independent predictor of myocardial infarction at two years in patients presenting with acute coronary syndrome.
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Serum myeloperoxidase and mortality in maintenance hemodialysis patients.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 48, Issue:1, 2006

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Anti-GBM and anti-MPO antibodies coexist in a case of pulmonary renal syndrome.
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Microscopic polyangiitis presenting as pulmonary-renal syndrome in a patient with long-standing diffuse cutaneous systemic sclerosis and antibodies to myeloperoxidase.
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Histological diversity of vasculitic lesions in MPO-ANCA-positive autopsy cases.
Pathology international, , Volume: 51, Issue:6, 2001

Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes.
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Temporomandibular joint arthritis as an initial presentation of acute myeloid leukemia with myelodysplasia-related changes: a report of an unusual case.
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5-HT induces temporomandibular joint nociception in rats through the local release of inflammatory mediators and activation of local β adrenoceptors.
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Molecular correlates of temporomandibular joint disease.
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Myeloid Sarcoma of the Testis in Children: Clinicopathologic and Immunohistochemical Characteristics With KMT2A (MLL) Gene Rearrangement Correlation.
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Acute myeloid leukemia mimicking primary testicular neoplasm. Presentation of a case with review of literature.
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Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism.
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Mechanisms of cell death in cholinergic basal forebrain neurons in chronic alcoholics.
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Action Of Thiourea and Sulfonamides On Peroxidases Of the Thyroid Gland.
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Myeloperoxidase-deficient polymorphonuclear leucocytes (VII): Incidence in untreated myeloproliferative disorders.
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[A case of primary myelofibrosis terminating in acute megakaryoblastic leukemia: identification by the demonstration of platelet peroxidase].
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Simultaneous detection of membrane markers with monoclonal antibodies and peroxidatic activities in leukaemia: ultrastructural analysis using a new method of fixation preserving the platelet peroxidase.
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Surface features of leukaemic megakaryocytic precursors. A study of 5 cases of megakaryoblastic leukaemia with scanning electron microscopy.
Scandinavian journal of haematology, , Volume: 30, Issue:2, 1983

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Ultrastructural aspects of megakaryocyte/platelet system in essential thrombocythemia.
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Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia.
Frontiers in immunology, , Volume: 13, 2022

Comparison of the structural dynamic and mitochondrial electron-transfer properties of the proapoptotic human cytochrome c variants, G41S, Y48H and A51V.
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Naturally Occurring Disease-Related Mutations in the 40-57 Ω-Loop of Human Cytochrome c Control Triggering of the Alkaline Isomerization.
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Microparticles generated by decompression stress cause central nervous system injury manifested as neurohypophysial terminal action potential broadening.
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Recovery of renal function in a dialysis-dependent patient with microscopic polyangiitis and both myeloperoxidase anti-neutrophil cytoplasmic antibodies and anti-glomerular basement membrane antibodies.
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Short-term induction of thrombocytopenia delays periodontal healing in rats with periodontal disease: participation of endostatin and vascular endothelial growth factor.
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Giant electron dense chains, clusters and granules in megakaryocytes and platelets with normal dense bodies: an inherited thrombocytopenic disorder IV. Ultrastructural cytochemistry and analytical electron microscopy.
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[no title available]
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Microscopic polyangiitis: A little-known new risk factor of venous thrombosis.
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Neutrophils are the initial cell type identified in deep venous thrombosis induced vein wall inflammation.
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Exploring the mechanism of the antithrombotic effects of Pueraria lobata and Pueraria lobata var. thomsonii based on network pharmacology.
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[no title available]
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Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia.
Frontiers in immunology, , Volume: 13, 2022

Neutrophil extracellular traps in patients with liver cirrhosis and hepatocellular carcinoma.
Scientific reports, , 09-09, Volume: 11, Issue:1, 2021

Severe Pulmonary Embolism, Thrombosis of Lower Extremity, Unexpected Mild Renal Disorder in MPO-ANCA Associated Vasculitis: A Case Report.
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, , Dec-31, Volume: 36, Issue:4, 2021

The expression of myeloperoxidase in thrombi is associated with reduced heme oxygenase-1 induction and worse left ventricular remodeling in patients with acute ST-elevation myocardial infarction.
Clinical cardiology, , Volume: 44, Issue:3, 2021

Persistence of Intraluminal Thrombus Makes Saccular Aneurysm More Biologically Active than Fusiform in an Experimental Rat Model.
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Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome.
Blood, , 09-03, Volume: 136, Issue:10, 2020

Thrombosis and necrosis of the feet in the course of vasculitis associated with perinuclear anti-neutrophil cytoplasmic antibodies.
Polish archives of internal medicine, , 12-22, Volume: 130, Issue:12, 2020

Predictors of neutrophil extracellular traps markers in type 2 diabetes mellitus: associations with a prothrombotic state and hypofibrinolysis.
Cardiovascular diabetology, , 04-16, Volume: 18, Issue:1, 2019

The myeloperoxidase product, hypochlorous acid, reduces thrombus formation under flow and attenuates clot retraction and fibrinolysis in human blood.
Free radical biology & medicine, , Volume: 141, 2019

IL-1β Blockade Attenuates Thrombosis in a Neutrophil Extracellular Trap-Dependent Breast Cancer Model.
Frontiers in immunology, , Volume: 10, 2019

Quantification of NETs-associated markers by flow cytometry and serum assays in patients with thrombosis and sepsis.
International journal of laboratory hematology, , Volume: 40, Issue:4, 2018

Comparison of Ticagrelor with Clopidogrel in Reducing Interleukin-17 and Myeloperoxidase Expression in Thrombus and Improving Postprocedural Coronary Flow in ST-segment Elevation Myocardial Infarction Patients.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, , Volume: 21, Issue:1, 2018

Neutrophil Extracellular Traps Participate in All Different Types of Thrombotic and Haemorrhagic Complications of Coronary Atherosclerosis.
Thrombosis and haemostasis, , Volume: 118, Issue:6, 2018

The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture.
Redox report : communications in free radical research, , Volume: 22, Issue:2, 2017

Human blood monocytes are able to form extracellular traps.
Journal of leukocyte biology, , Volume: 102, Issue:3, 2017

Myeloperoxidase Is a Negative Regulator of Phospholipid-Dependent Coagulation.
Thrombosis and haemostasis, , Volume: 117, Issue:12, 2017

Hypoxia-preconditioned mesenchymal stem cells ameliorate ischemia/reperfusion-induced lung injury.
PloS one, , Volume: 12, Issue:11, 2017

Hypochlorous acid generated by neutrophils inactivates ADAMTS13: an oxidative mechanism for regulating ADAMTS13 proteolytic activity during inflammation.
The Journal of biological chemistry, , Jan-16, Volume: 290, Issue:3, 2015

The effect of rosuvastatin on thromboinflammation in the setting of acute coronary syndrome.
Journal of thrombosis and thrombolysis, , Volume: 39, Issue:2, 2015

Predictive value of serum myeloperoxidase activity for thrombosis of arteriovenous fistulas.
Hemodialysis international. International Symposium on Home Hemodialysis, , Volume: 18, Issue:3, 2014

Neutrophils, neutrophil extracellular traps and interleukin-17 associate with the organisation of thrombi in acute myocardial infarction.
Thrombosis and haemostasis, , Volume: 109, Issue:2, 2013

Intraluminal abdominal aortic aneurysm thrombus is associated with disruption of wall integrity.
Journal of vascular surgery, , Volume: 57, Issue:1, 2013

Postischemic treatment with ethyl pyruvate prevents adenosine triphosphate depletion, ameliorates inflammation, and decreases thrombosis in a murine model of hind-limb ischemia and reperfusion.
The Journal of trauma, , Volume: 70, Issue:1, 2011

Comparable biocompatibility of Phisio- and Bioline-coated cardiopulmonary bypass circuits indicated by the inflammatory response.
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Risk factor correlates of platelet and leukocyte markers assessed by flow cytometry in a population-based sample.
Atherosclerosis, , Volume: 205, Issue:1, 2009

Myeloperoxidase as a marker of hemodialysis biocompatibility and oxidative stress: the underestimated modifying effects of heparin.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 47, Issue:1, 2006

Crosstalk between thrombosis and inflammation in lung reperfusion injury.
The Annals of thoracic surgery, , Volume: 81, Issue:3, 2006

Blood oxidative status and selectins plasma levels in healthy donors receiving granulocyte-colony stimulating factor.
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The year in atherothrombosis.
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[The role of oxidative stress and arterial blood supply in the transplanted liver function].
Orvosi hetilap, , Nov-09, Volume: 144, Issue:45, 2003

Platelet-activating factor antagonist, SM-12502, attenuates experimental glomerular thrombosis in rats.
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Alterations in the free radical generation and nitric oxide release from rat peripheral polymorphonuclear leukocytes following thrombosis.
Thrombosis research, , Aug-01, Volume: 87, Issue:3, 1997

Extrinsic-pathway enzyme-linked coagulation assay (EP-ELCA). A clot-based alternative to prothrombin time for measurement of extrinsic pathway factors in plasma.
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Acquired neutrophil myeloperoxidase deficiency: an indicator of subclinical activation of blood coagulation?
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Lipoprotein-associated phospholipase A2, myeloperoxidase and vascular endothelial growth factor - predictors of high vascular risk in respiratory bacterial infections.
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Possible linkage between microscopic polyangiitis and thrombosis via neutrophil extracellular traps.
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High Expression of MMP-9 in Primary Tumors and High Preoperative MPO in Serum Predict Improved Prognosis in Colorectal Cancer with Operable Liver Metastases.
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[no title available]
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Sleeve Gastrectomy Provides Cardioprotection from Oxidative Stress In Vitro Due to Reduction of Circulating Myeloperoxidase.
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Reversal of murine alcoholic steatohepatitis by pepducin-based functional blockade of interleukin-8 receptors.
Gut, , Volume: 66, Issue:5, 2017

The efficacy of tyrosine kinase inhibitor dasatinib on colonic mucosal damage in murine model of colitis.
Clinics and research in hepatology and gastroenterology, , Volume: 40, Issue:4, 2016

The Algal Meroterpene 11-Hydroxy-1'-O-Methylamentadione Ameloriates Dextran Sulfate Sodium-Induced Colitis in Mice.
Marine drugs, , Aug-05, Volume: 14, Issue:8, 2016

[Cigarette smoking in different manners induces acute lung injury in rats].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, , 05-25, Volume: 45, Issue:5, 2016

Oat β-glucan ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice.
Food & function, , Volume: 6, Issue:11, 2015

Brugia malayi cystatin therapeutically ameliorates dextran sulfate sodium-induced colitis in mice.
Journal of digestive diseases, , Volume: 16, Issue:10, 2015

Effects of Dietary Plant-Origin Glucosylceramide on Bowel Inflammation in DSS-Treated Mice.
Journal of oleo science, , Volume: 64, Issue:7, 2015

Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis.
World journal of gastroenterology, , Jan-07, Volume: 21, Issue:1, 2015

CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a.
Journal of immunology research, , Volume: 2015, 2015

Chemotherapy-associated steatohepatitis induced by irinotecan: a novel animal model.
Cancer chemotherapy and pharmacology, , Volume: 74, Issue:4, 2014

Atorvastatin attenuates the paraquat-induced pulmonary inflammation via PPARγ receptors: a new indication for atorvastatin.
Pesticide biochemistry and physiology, , Volume: 114, 2014

Inhibition of the dephosphorylation of eukaryotic initiation factor 2α ameliorates murine experimental colitis.
Digestion, , Volume: 90, Issue:3, 2014

Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis.
Infection and immunity, , Volume: 82, Issue:4, 2014

The effects of sports drink osmolality on fluid intake and immunoendocrine responses to cycling in hot conditions.
Journal of nutritional science and vitaminology, , Volume: 59, Issue:3, 2013

Green tea and vitamin E enhance exercise-induced benefits in body composition, glucose homeostasis, and antioxidant status in elderly men and women.
Journal of the American College of Nutrition, , Volume: 32, Issue:1, 2013

Thymosin β4 protects C57BL/6 mice from bleomycin-induced damage in the lung.
European journal of clinical investigation, , Volume: 43, Issue:3, 2013

Protective effect of myricetin in dextran sulphate sodium-induced murine ulcerative colitis.
Molecular medicine reports, , Volume: 7, Issue:2, 2013

Effects of Streptococcus thermophilus TH-4 in a rat model of doxorubicin-induced mucositis.
Scandinavian journal of gastroenterology, , Volume: 48, Issue:8, 2013

Loss of phosphoinositide 3-kinase P110γ is protective in the acute phase but detrimental in the resolution phase of hapten-induced colitis.
Inflammatory bowel diseases, , Volume: 19, Issue:3, 2013

Proinflammatory and oxidative stress markers in patients submitted to Roux-en-Y gastric bypass after 1 year of follow-up.
European journal of clinical nutrition, , Volume: 66, Issue:8, 2012

Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis.
Journal of Crohn's & colitis, , Volume: 6, Issue:2, 2012

Formylated peptides are important virulence factors in Staphylococcus aureus arthritis in mice.
The Journal of infectious diseases, , Jan-15, Volume: 205, Issue:2, 2012

Impact of disrupting adenosine A₃ receptors (A₃⁻/⁻ AR) on colonic motility or progression of colitis in the mouse.
Inflammatory bowel diseases, , Volume: 17, Issue:8, 2011

Mycobacterium bovis Bacillus Calmette-Guérin killed by extended freeze-drying reduces colitis in mice.
Gastroenterology, , Volume: 141, Issue:2, 2011

Anti-inflammatory effects of methanol extract of Patrinia scabiosaefolia in mice with ulcerative colitis.
Journal of ethnopharmacology, , Jul-14, Volume: 136, Issue:3, 2011

Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling.
Experimental & molecular medicine, , Feb-28, Volume: 42, Issue:2, 2010

Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 299, Issue:1, 2010

Roux-en-Y bypass gastroplasty: markers of oxidative stress 6 months after surgery.
Obesity surgery, , Volume: 20, Issue:9, 2010

Partially hydrolyzed guar gum attenuates the severity of pouchitis in a rat model of ileal J pouch-anal anastomosis.
Digestive diseases and sciences, , Volume: 54, Issue:3, 2009

3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice.
Inflammatory bowel diseases, , Volume: 15, Issue:8, 2009

Neuromuscular changes in a rat model of colitis.
Autonomic neuroscience : basic & clinical, , Aug-18, Volume: 141, Issue:1-2, 2008

Protective effect of purinergic agonist ATPgammaS against acute lung injury.
American journal of physiology. Lung cellular and molecular physiology, , Volume: 294, Issue:2, 2008

Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice.
American journal of physiology. Lung cellular and molecular physiology, , Volume: 294, Issue:2, 2008

Blocking lymphotoxin beta receptor signalling exacerbates acute DSS-induced intestinal inflammation--opposite functions for surface lymphotoxin expressed by T and B lymphocytes.
Molecular immunology, , Volume: 45, Issue:1, 2008

In vivo treatment with the herbal phenylethanoid acteoside ameliorates intestinal inflammation in dextran sulphate sodium-induced colitis.
Clinical and experimental immunology, , Volume: 148, Issue:2, 2007

Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice.
Clinical and experimental immunology, , Volume: 146, Issue:2, 2006

Protection against dextran sodium sulfate-induced colitis by dehydroepiandrosterone and 7alpha-hydroxy-dehydroepiandrosterone in the rat.
Steroids, , Volume: 71, Issue:3, 2006

Attenuation of bleomycin-induced lung fibrosis in rats by mesna.
European journal of pharmacology, , Feb-10, Volume: 509, Issue:1, 2005

Ameliorating effect of hepatocyte growth factor on inflammatory bowel disease in a murine model.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 288, Issue:4, 2005

Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin.
The American journal of pathology, , Volume: 167, Issue:5, 2005

Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury.
The European respiratory journal, , Volume: 25, Issue:2, 2005

[A-leukemic caecal myeloid sarcoma: a difficult diagnosis].
Annales de pathologie, , Volume: 24, Issue:5, 2004

The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitis.
European journal of pharmacology, , Apr-18, Volume: 466, Issue:3, 2003

Inflammatory bio-markers and cardiovascular risk prediction.
Journal of internal medicine, , Volume: 252, Issue:4, 2002

Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis.
Gut, , Volume: 51, Issue:3, 2002

Interleukin-12 induced interferon-gamma increases inflammation in acute dextran sulfate sodium induced colitis in mice.
European cytokine network, , Volume: 11, Issue:1, 2000

Effect of intracolonic benzalkonium chloride on trinitrobenzene sulphonic acid-induced colitis in the rat.
Alimentary pharmacology & therapeutics, , Volume: 12, Issue:3, 1998

Neutrophil accumulation after traumatic brain injury in rats: comparison of weight drop and controlled cortical impact models.
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Tobacco differentially affects the clinical-biological phenotypes of ANCA-associated vasculitides.
Clinical and experimental rheumatology, , Volume: 33, Issue:2 Suppl 89

Amelioration of methotrexate-induced enteritis by melatonin in rats.
Cell biochemistry and function, , Volume: 22, Issue:3

Crescentic Glomerulonephritis with Fibrinoid Vasculitis after Administration of Influenza Vaccine.
Internal medicine (Tokyo, Japan), , Apr-01, Volume: 62, Issue:7, 2023

Myeloperoxidase immunohistochemical staining can identify glomerular endothelial cell injury in dense deposit disease.
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Prolonged infections associated with antineutrophil cytoplasmic antibodies specific to proteinase 3 and myeloperoxidase: diagnostic and therapeutic challenge.
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Use of immunofluorescence and confocal laser scanning microscopy in identifying rare cases of anti-neutrophil cytoplasmic antibodies (ANCA) showing dual specificities to myeloperoxidase and proteinase3.
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Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis.
Laboratory investigation; a journal of technical methods and pathology, , Volume: 82, Issue:1, 2002

Renal ischemia/reperfusion injury contributes to renal damage in experimental anti-myeloperoxidase-associated proliferative glomerulonephritis.
Kidney international, , Volume: 47, Issue:4, 1995

Brother and sister with myeloperoxidase associated autoimmune disease.
Annals of the rheumatic diseases, , Volume: 53, Issue:3, 1994

Atypical presence of antimyeloperoxidase antibodies in 2 transplanted patients.
Nephron, , Volume: 63, Issue:4, 1993

Nature-inspired nanozymes as signal markers for in-situ signal amplification strategy: A portable dual-colorimetric immunochromatographic analysis based on smartphone.
Biosensors & bioelectronics, , Aug-15, Volume: 210, 2022

Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia.
Leukemia, , Volume: 28, Issue:8, 2014

The histone deacetylase inhibitor MGCD0103 induces apoptosis in B-cell chronic lymphocytic leukemia cells through a mitochondria-mediated caspase activation cascade.
Molecular cancer therapeutics, , Volume: 9, Issue:5, 2010

Phase II study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia.
British journal of haematology, , Volume: 147, Issue:4, 2009

Enzyme levels and G-463A polymorphism of myeloperoxidase in chronic lymphocytic leukemia and multiple myeloma.
Leukemia & lymphoma, , Volume: 50, Issue:12, 2009

Catalyzed signal amplification for cyclin D1 detection in mantle cell lymphoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, , Volume: 16, Issue:2, 2003

Detection of low abundance mRNA of myeloid specific genes in cells of acute and chronic lymphoid leukemias by cRNA hybridization.
Leukemia, , Volume: 4, Issue:10, 1990

Chemiluminescence response of polymorphonuclear leucocytes to serum-opsonized zymosan--a predictive parameter for infections and prognosis in multiple myeloma patients.
Clinical and laboratory haematology, , Volume: 10, Issue:4, 1988

Relapsed B-acute lymphoblastic leukemia with aberrant myeloperoxidase expression following CAR T-cell therapy: A diagnostic challenge.
American journal of hematology, , Volume: 94, Issue:9, 2019

Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia.
International journal of cancer, , Jan-10, Volume: 97, Issue:2, 2002

Prevalence of myeloperoxidase gene expression in infant acute lymphocytic leukemia.
American journal of clinical pathology, , Volume: 110, Issue:5, 1998

[Biphenotypic acute leukemia with Ph1 chromosome, M-BCR-, myeloperoxidase+, and CALLA+].
[Rinsho ketsueki] The Japanese journal of clinical hematology, , Volume: 32, Issue:3, 1991

Isolated myeloperoxidase expression in pediatric B/myeloid mixed phenotype acute leukemia is linked with better survival.
Blood, , 02-01, Volume: 131, Issue:5, 2018

Complementarity of evaluation of myeloperoxidase expression by flow cytometry and immunohistochemistry on bone marrow trephine biopsy sections in acute myeloid leukemia.
Cytometry. Part B, Clinical cytometry, , Volume: 86, Issue:1, 2014

A threshold of 10% for myeloperoxidase by flow cytometry is valid to classify acute leukemia of ambiguous and myeloid origin.
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Acute leukemias of ambiguous lineage.
Seminars in diagnostic pathology, , Volume: 29, Issue:1, 2012

CD117 expression is a sensitive but nonspecific predictor of FLT3 mutation in T acute lymphoblastic leukemia and T/myeloid acute leukemia.
American journal of clinical pathology, , Volume: 137, Issue:2, 2012

Spinal cord compression as the initial presentation of acute biphenotypic leukaemia.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 16, Issue:12, 2009

What is the optimal treatment for biphenotypic acute leukemia?
Haematologica, , Volume: 94, Issue:12, 2009

Immunophenotypes in adult acute lymphocytic leukemia. Role of flow cytometry in diagnosis and monitoring of disease.
Hematology/oncology clinics of North America, , Volume: 14, Issue:6, 2000

Mixed-lineage leukemia revisited: acute lymphocytic leukemia with myeloperoxidase-positive blasts by electron microscopy.
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Definition of acute biphenotypic leukemia.
Haematologica, , Volume: 82, Issue:1

[Application of flow cytometry in the differential diagnosis of lymphoma/leukemia with aberrant antigen expression].
Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 33, Issue:6, 2004

Acute biphenotypic leukaemia.
Haematologica, , Volume: 87, Issue:1, 2002

Differentiation of acute myeloid leukemia from B- and T-lineage acute lymphoid leukemias by real-time quantitative reverse transcription-PCR of lineage marker mRNAs.
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Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia.
International journal of cancer, , Jan-10, Volume: 97, Issue:2, 2002

Immunophenotypes in adult acute lymphocytic leukemia. Role of flow cytometry in diagnosis and monitoring of disease.
Hematology/oncology clinics of North America, , Volume: 14, Issue:6, 2000

Myeloperoxidase detection by three-color flow cytometry in acute lymphoblastic leukemia.
American journal of clinical pathology, , Volume: 112, Issue:1, 1999

Detection of myeloperoxidase by flow cytometry in acute leukemia.
Cytometry, , Aug-15, Volume: 34, Issue:4, 1998

High prevalence of T cell receptor D delta 2(D delta)J delta rearrangement in CD7-positive early T cell acute lymphoblastic leukemia.
Leukemia, , Volume: 10, Issue:4, 1996

Heterogeneity of CD7+ 4- 8- 1- leukemia: usefulness of cytoplasmic antigen detection for subclassification.
Leukemia, , Volume: 7, Issue:11, 1993

Mature T-lineage leukemia with growth factor-induced multilineage differentiation.
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[The immunological effect of anti-leukemic tumor induced by eosinophilic granulocyte].
Zhonghua nei ke za zhi, , Volume: 52, Issue:5, 2013

Leukemia cutis: case report and review of literature.
Applied immunohistochemistry & molecular morphology : AIMM, , Volume: 18, Issue:2, 2010

Serglycin proteoglycan in hematologic malignancies: a marker of acute myeloid leukemia.
Leukemia, , Volume: 21, Issue:12, 2007

Distinguishing between proliferating nodal lymphoid blasts in chronic myelogenous leukemia and non-Hodgkin lymphoma: report of three cases and detection of a bcr/abl fusion signal by single-cell analysis.
Pathology international, , Volume: 55, Issue:5, 2005

Myeloperoxidase cytochemical negativity: an unexpected but intrinsic property of blasts of all phases of chronic myeloid leukemia.
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[Myeloperoxidase].
Nihon rinsho. Japanese journal of clinical medicine, , Volume: 62 Suppl 12, 2004

Expression of NK-associated antigens in extramedullary lymph nodal blast crisis of chronic myeloid leukemia on fine-needle cytology.
Diagnostic cytopathology, , Volume: 27, Issue:3, 2002

CD56+ blastic transformation of chronic myeloid leukemia involving the skin.
Journal of cutaneous pathology, , Volume: 26, Issue:10, 1999

Blast crisis of chronic myelogenous leukemia exhibiting immunophenotypic features of a myeloid/natural killer cell precursor.
International journal of hematology, , Volume: 69, Issue:2, 1999

Myeloperoxidase mRNA analysis in acute lymphoblastic leukemia.
Diagnostic molecular pathology : the American journal of surgical pathology, part B, , Volume: 6, Issue:3, 1997

Myeloperoxidase mRNA analysis in acute lymphoblastic leukemia.
Diagnostic molecular pathology : the American journal of surgical pathology, part B, , Volume: 5, Issue:4, 1996

The value of the ultrastructural pattern of myeloperoxidase and platelet peroxidase in identification of two blastic cell types during transformation of a chronic myeloproliferative disorder.
Haematologia, , Volume: 27, Issue:3, 1996

Immunophenotype and ultrastructural studies in blast crisis of chronic myeloid leukemia.
Leukemia & lymphoma, , Volume: 19, Issue:3-4, 1995

Direct detection of the Philadelphia chromosome in CD20-positive lymphocytes in chronic myeloid leukemia by tri-color immunophenotyping/FISH.
Leukemia, , Volume: 8, Issue:11, 1994

Establishment of a new cell line with the characteristics of a multipotential progenitor from a patient with chronic myelogenous leukemia in early erythroblastic crisis.
Leukemia, , Volume: 8, Issue:1, 1994

Detection of leukemic blasts in peripheral blood specimens by reverse transcriptase polymerase chain reaction assay for myeloperoxidase mRNA.
Diagnostic molecular pathology : the American journal of surgical pathology, part B, , Volume: 2, Issue:4, 1993

Protection by antibiotics against myeloperoxidase-dependent cytotoxicity to lung epithelial cells in vitro.
The Journal of clinical investigation, , Volume: 91, Issue:1, 1993

Characterization of Philadelphia-chromosome-positive acute leukemia by clinical, immunocytochemical, and gene analysis.
Leukemia, , Volume: 6, Issue:9, 1992

Posttranslational processing of defensins in immature human myeloid cells.
Blood, , Mar-15, Volume: 79, Issue:6, 1992

Ultrastructural and ultracytochemical differences between megakaryoblastic leukemia in children and adults. Analysis of 49 patients.
Cancer, , Jul-15, Volume: 70, Issue:2, 1992

Determination of anti-neutrophil cytoplasm antibodies (ANCA) specificity by immunofluorescence on chronic myelocytic leukemia cells.
Journal of immunological methods, , Feb-14, Volume: 147, Issue:1, 1992

Enhanced granulocyte function in a case of chronic granulocytic leukemia in a dog.
Veterinary immunology and immunopathology, , Volume: 28, Issue:2, 1991

[Biphenotypic acute leukemia with Ph1 chromosome, M-BCR-, myeloperoxidase+, and CALLA+].
[Rinsho ketsueki] The Japanese journal of clinical hematology, , Volume: 32, Issue:3, 1991

Analysis of human neutrophil granule protein composition in chronic myeloid leukaemia by immuno-electron microscopy.
Cell and tissue research, , Volume: 258, Issue:1, 1989

Human neutrophil gelatinase is a component of specific granules.
The Journal of clinical investigation, , Volume: 84, Issue:5, 1989

Expression of the myeloperoxidase gene in acute and chronic myeloid leukemias: relationship to the expression of cell cycle-related genes.
Leukemia, , Volume: 3, Issue:6, 1989

Applicability of using acrylic resins in post-embedding ultrastructural immunolabelling of human neutrophil granule proteins.
The Histochemical journal, , Volume: 21, Issue:5, 1989

Bone marrow biopsy imprint preparations: use for molecular diagnostics in leukemias.
Annals of clinical and laboratory science, , Volume: 23, Issue:6

Bilineage T-lymphoblastic/myeloid extramedullary blast crisis in chronic myelogenous leukemia.
Indian journal of pathology & microbiology, , Volume: 59, Issue:1

Parallel tubular granules in human immature neutrophils--an electron microscopic study.
Leukemia & lymphoma, , Volume: 15, Issue:1-2, 1994

Electron microscopic findings of parallel tubular granules in a case of chronic neutrophilic leukaemia.
Journal of clinical pathology, , Volume: 47, Issue:4, 1994

Acute basophilic leukaemia: eight unsuspected new cases diagnosed by electron microscopy.
British journal of haematology, , Volume: 120, Issue:5, 2003

Acute basophilic leukemia.
European journal of haematology, , Volume: 67, Issue:2, 2001

Flow cytometric analysis of neutrophil myeloperoxidase expression in peripheral blood for ruling out myelodysplastic syndromes: a diagnostic accuracy study.
Haematologica, , Volume: 104, Issue:12, 2019

The value of immunohistochemistry for CD14, CD123, CD33, myeloperoxidase and CD68R in the diagnosis of acute and chronic myelomonocytic leukaemias.
Histopathology, , Volume: 60, Issue:6, 2012

Histologic and immunohistologic characterization of skin localization of myeloid disorders: a study of 173 cases.
American journal of clinical pathology, , Volume: 135, Issue:2, 2011

Splenic pathology in myelodysplasia: a report of 13 cases with clinical correlation.
The American journal of surgical pathology, , Volume: 22, Issue:10, 1998

Extramedullary myeloid cell tumors arising in the setting of chronic myelomonocytic leukemia. A report of two cases.
Archives of pathology & laboratory medicine, , Volume: 120, Issue:1, 1996

Selective involvement of monocytes by acquired myeloperoxidase deficiency in a case of chronic myelomonocytic leukemia.
Annals of hematology, , Volume: 66, Issue:5, 1993

The effects of GM-CSF on myeloperoxidase release in normal and myelodysplastic neutrophils.
Leukemia research, , Volume: 17, Issue:12, 1993

Plasmacytoid T-zone cell proliferation in a patient with chronic myelomonocytic leukemia. Histologic and immunohistologic characterization.
The American journal of surgical pathology, , Volume: 15, Issue:1, 1991

A clinical case of acute myelomonocytic leukemia in a Holstein cow.
The Journal of veterinary medical science, , May-17, Volume: 83, Issue:5, 2021

What lies inside the cup?
European journal of haematology, , Volume: 94, Issue:3, 2015

The value of immunohistochemistry for CD14, CD123, CD33, myeloperoxidase and CD68R in the diagnosis of acute and chronic myelomonocytic leukaemias.
Histopathology, , Volume: 60, Issue:6, 2012

Comparison of myeloperoxidase detection by flow cytometry using two different clones of monoclonal antibodies.
The Malaysian journal of pathology, , Volume: 26, Issue:2, 2004

Acute myeloid leukemia mimicking primary testicular neoplasm. Presentation of a case with review of literature.
European journal of haematology, , Volume: 70, Issue:4, 2003

"Isolated" peritoneal granulocytic sarcoma with molecular and chromosomal bone marrow involvement.
Haematologica, , Volume: 87, Issue:1, 2002

Acute myeloblastic leukemia (AML) with inv (16)(p13;q22) and the rare I type CBFbeta-MYH11 transcript: report of two new cases.
Leukemia, , Volume: 16, Issue:1, 2002

[Total and selective deficiency of myeloperoxidase in peripheral monocytes lead to diagnosis of acute myelomonoblastic leukemia].
Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg, , Volume: 135, Issue:1, 1998

CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells.
Oncogene, , Volume: 15, Issue:11, 1997

An allelic association implicates myeloperoxidase in the etiology of acute promyelocytic leukemia.
Blood, , Oct-01, Volume: 90, Issue:7, 1997

Distinct lysozyme content in different subtypes of acute myeloid leukaemic cells: an ultrastructural immunogold study.
British journal of haematology, , Volume: 88, Issue:2, 1994

A myeloid-lineage-specific enhancer upstream of the mouse myeloperoxidase (MPO) gene.
Leukemia, , Volume: 8, Issue:5, 1994

Acute myelomonocytic leukemia (M4) and t(15;17)(q24;q21). A diagnostic dilemma.
Cancer genetics and cytogenetics, , Oct-01, Volume: 70, Issue:1, 1993

Quantitative enzyme determination in acute myeloid leukemia.
Leukemia research, , Volume: 15, Issue:6, 1991

Simultaneous occurrence of myelomonocytic leukemia and multiple myeloma: involvement of common leukemic progenitors and their developmental abnormality of "lineage infidelity".
Journal of cellular physiology, , Volume: 148, Issue:3, 1991

Acute myelomonocytic leukemia in a horse.
Veterinary pathology, , Volume: 28, Issue:4, 1991

[Spontaneous differentiation from myeloperoxidase-negative acute nonlymphocytic leukemia to acute myelomonocytic leukemia].
[Rinsho ketsueki] The Japanese journal of clinical hematology, , Volume: 30, Issue:10, 1989

[A study of free radical defense and oxidative stress in the sera of patients with neuroimmunological disorders].
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Nasal complaints and signs of disease in farmers--a methodological study.
Acta oto-laryngologica, , Volume: 128, Issue:2, 2008

Influence of personal factors on nasal patency and lavage biomarkers in white-collar workers.
Rhinology, , Volume: 38, Issue:3, 2000

Nasal patency and biomarkers in nasal lavage--the significance of air exchange rate and type of ventilation in schools.
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Use of pharmacodynamic endpoints for the evaluation of levofloxacin for the treatment of acute maxillary sinusitis.
Diagnostic microbiology and infectious disease, , Volume: 61, Issue:1, 2008

Proteomic analyses of monocytes obtained from Hispanic women with HIV-associated dementia show depressed antioxidants.
Proteomics. Clinical applications, , Volume: 4, Issue:8-9, 2010

NETosis in Psoriatic Arthritis: Serum MPO-DNA Complex Level Correlates With Its Disease Activity.
Frontiers in immunology, , Volume: 13, 2022

Assessment of serum and synovial fluid MMP-3 and MPO as biomarkers for psoriatic arthritis and their relation to disease activity indices.
Rheumatology international, , Volume: 42, Issue:9, 2022

Genetic Analysis of MPO Variants in Four Psoriasis Subtypes in Patients from Germany.
The Journal of investigative dermatology, , Volume: 141, Issue:8, 2021

Differentiating Psoriatic Arthritis From Psoriasis Without Psoriatic Arthritis Using Novel Serum Biomarkers.
Arthritis care & research, , Volume: 70, Issue:3, 2018

MPO antibody-positive vasculitis in a patient with psoriatic arthritis and gold-induced membranous glomerulonephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 13, Issue:8, 1998

Antineutrophil cytoplasmic antibodies in rheumatoid arthritis patients.
British journal of rheumatology, , Volume: 35, Issue:1, 1996

Myeloperoxidase and Other Markers of Neutrophil Activation Associate With Malaria and Malaria/HIV Coinfection in the Human Placenta.
Frontiers in immunology, , Volume: 12, 2021

Investigating the histopathological findings and immunolocalization of rickettsialpox infection in skin biopsies: A case series and review of the literature.
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Neutrophil Vaccination Dynamics and Their Capacity To Mediate B Cell Help in Rhesus Macaques.
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Relationship between plasma bilirubin level and oxidative stress markers in HIV-infected patients on atazanavir- vs. efavirenz-based antiretroviral therapy.
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Myeloperoxidase in human peripheral blood lymphocytes: Production and subcellular localization.
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Plasma plasminogen activator inhibitor-1 predicts myocardial infarction in HIV-1-infected individuals.
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Changes in biomarkers of cardiovascular risk after a switch to abacavir in HIV-1-infected individuals receiving combination antiretroviral therapy.
HIV medicine, , Volume: 10, Issue:10, 2009

Increased carotid intima media thickness and cardiac biomarkers in HIV infected children.
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The saliva immunology mechanisms and periodontal status in HIV infected subjects.
Advances in medical sciences, , Volume: 51 Suppl 1, 2006

The evaluation of lysozyme concentration and peroxidase activity in non-stimulated saliva of patients infected with HIV.
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Impaired phagocyte oxidative capacity in human immunodeficiency virus-infected children.
The Journal of infectious diseases, , Volume: 179, Issue:3, 1999

Quantitative, competitive PCR assay for HIV-1 using a microplate-based detection system.
BioTechniques, , Volume: 24, Issue:5, 1998

Matrix metalloproteinases-1, -3 and -8 and myeloperoxidase in saliva of patients with human immunodeficiency virus infection.
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Anti-nuclear, anti-neutrophil cytoplasmic and anti-glomerular basement membrane antibodies in HIV-infected individuals.
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Use of antineutrophil cytoplasmic autoantibodies in diagnosing vasculitis in a Chinese patient population.
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Anti-neutrophil cytoplasm antibodies in HIV infection.
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Viricidal effect of Lactobacillus acidophilus on human immunodeficiency virus type 1: possible role in heterosexual transmission.
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[Morphological characteristics of inflammation in HIV-associated pulmonary tuberculosis with regard to the expression of myeloperoxidase].
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Clinical and pro-host effects of cefaclor in prophylaxis of recurrent otitis media in HIV-infected children.
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Higher plasma myeloperoxidase levels are not associated with an increased risk for cardiovascular events in HIV-infected adults.
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Immunofluorescence of rabbit corneas after collagen cross-linking treatment with riboflavin and ultraviolet A.
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ANCA and IgA glomerulonephritis all in one: prognosis and complications.
BMJ case reports, , Oct-09, Volume: 2017, 2017

Beneficial effects of the ethanol extract of Caesalpinia pyramidalis on the inflammatory response and abdominal hyperalgesia in rats with acute pancreatitis.
Journal of ethnopharmacology, , Jul-13, Volume: 142, Issue:2, 2012

Serine proteases mediate inflammatory pain in acute pancreatitis.
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[A rare tumor of the main biliary duct].
Annales de pathologie, , Volume: 30, Issue:6, 2010

Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice.
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[A-leukemic caecal myeloid sarcoma: a difficult diagnosis].
Annales de pathologie, , Volume: 24, Issue:5, 2004

Acute myeloid leukemia mimicking primary testicular neoplasm. Presentation of a case with review of literature.
European journal of haematology, , Volume: 70, Issue:4, 2003

Exacerbation of Acanthamoeba keratitis in animals treated with anti-macrophage inflammatory protein 2 or antineutrophil antibodies.
Infection and immunity, , Volume: 69, Issue:5, 2001

Early Depletion of Neutrophils Reduces Retinal Inflammation and Neovascularization in Mice with Oxygen-Induced Retinopathy.
International journal of molecular sciences, , Oct-27, Volume: 24, Issue:21, 2023

Intravitreal thalidomide ameliorates inflammation in a model of experimental uveitis induced by BCG.
International immunopharmacology, , Volume: 81, 2020

Possible involvement of NETosis in inflammatory processes in the eye: Evidence from a small cohort of patients.
Molecular vision, , Volume: 23, 2017

Effects of systemically applied allopurinol and prednisolone on experimental autoimmune uveitis.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, , Volume: 237, Issue:6, 1999

Synergistic uveitic effects of tumor necrosis factor-alpha and interleukin-1 beta.
Investigative ophthalmology & visual science, , Volume: 33, Issue:7, 1992

Does two episodes of acute urinary retention lead to additional ischemia-reperfusion injury in rat bladder?
International urology and nephrology, , Volume: 38, Issue:1, 2006

Increased RANKL and IL-6 levels might result in high bone turnover in a case of a CD34+/CD117+/myeloperoxidase(+dim) acute myeloid leukemia presenting with severe hypercalcemia and lumbar spine fractures.
Leukemia research, , Volume: 35, Issue:11, 2011

Leukocyte myeloperoxidase and pathogenesis of the post-polio syndrome.
Scandinavian journal of infectious diseases, , Volume: 42, Issue:11-12, 2010

Self-reported food intolerance and mucosal reactivity after rectal food protein challenge in patients with rheumatoid arthritis.
Scandinavian journal of rheumatology, , Volume: 39, Issue:4, 2010

Gastrointestinal sensitivity to soy and milk proteins in patients with IgA nephropathy.
Clinical nephrology, , Volume: 74, Issue:5, 2010

Cow's milk protein sensitivity assessed by the mucosal patch technique is related to irritable bowel syndrome in patients with primary Sjögren's syndrome.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 38, Issue:6, 2008

Mucosal reactivity to cow's milk protein in coeliac disease.
Clinical and experimental immunology, , Volume: 147, Issue:3, 2007

A 70-year-old man with pulmonary infiltrates and a positive antineutrophil cytoplasmic autoantibody test result.
Chest, , Volume: 127, Issue:3, 2005

Myeloperoxidase-positive intravascular large B-cell lymphoma.
Archives of pathology & laboratory medicine, , Volume: 125, Issue:7, 2001

Cephotaxime-associated allergic interstitial nephritis and MPO-ANCA positive vasculitis.
Renal failure, , Volume: 22, Issue:2, 2000

Human eosinophil peroxidase enhances tumor necrosis factor and hydrogen peroxide release by human monocyte-derived macrophages.
European journal of immunology, , Volume: 25, Issue:5, 1995

Inactivation of the DCC tumor suppressor gene in a B-cell lymphoma cell line with the alteration of chromosome 18.
American journal of hematology, , Volume: 50, Issue:2, 1995

Characterisation of a light chain loss variant of the BCL1 lymphoma.
Molecular immunology, , Volume: 28, Issue:7, 1991

[New approach to determine the pharmacodynamic effects of histone deacetylases inhibitors].
Pharmazie in unserer Zeit, , Volume: 39, Issue:3, 2010

Modulatory effect of hydrogen peroxide on tumoral lymphocytes proliferation.
Immunopharmacology and immunotoxicology, , Volume: 31, Issue:1, 2009

Bridging of neutrophils to target cells by opsonized zymosan enhances the cytotoxicity of neutrophil-produced H2O2.
Journal of immunology (Baltimore, Md. : 1950), , Sep-01, Volume: 159, Issue:5, 1997

A case of intravascular large B-cell lymphoma with renal involvement presenting with elevated serum ANCA titers.
CEN case reports, , Volume: 10, Issue:1, 2021

A phase 2 study of mocetinostat, a histone deacetylase inhibitor, in relapsed or refractory lymphoma.
British journal of haematology, , Volume: 178, Issue:3, 2017

T-cell/histiocyte-rich large B-cell lymphoma with zonal expansion of fibroblastic reticulum cells and infiltration by a subpopulation of myeloperoxidase positive histiocytes.
Pathology, research and practice, , Volume: 210, Issue:12, 2014

[Granulocytic sarcoma: a clinical and pathologic analysis of ten cases].
Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 41, Issue:5, 2012

Myeloperoxidase-positive intravascular large B-cell lymphoma.
Archives of pathology & laboratory medicine, , Volume: 125, Issue:7, 2001

Granulocyte-colony stimulating factor, granulocyte-macrophage colony stimulating factor and interleukin 4 induce differentiation in the U-937 human monocytic leukemia cell line.
Leukemia & lymphoma, , Volume: 22, Issue:1-2, 1996

Human cell lines U-937, THP-1 and Mono Mac 6 represent relatively immature cells of the monocyte-macrophage cell lineage.
Leukemia, , Volume: 8, Issue:9, 1994

[Sinus lining cells:morphology, function and neoplasia].
Verhandlungen der Deutschen Gesellschaft fur Pathologie, , Volume: 76, 1992

Human monocyte-mediated tumor cytotoxicity. I. Demonstration of an oxygen-dependent myeloperoxidase-independent mechanism.
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Oxidant and antioxidant balance in children with bacteremia.
Minerva pediatrics, , Volume: 75, Issue:6, 2023

Biomarker of neutrophil extracellular traps is associated with deep-seated infections and predicts mortality and cardiovascular morbidity in commensal streptococcal bacteremia.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, , Volume: 55, Issue:5, 2022

IL-17 can be protective or deleterious in murine pneumococcal pneumonia.
PLoS pathogens, , Volume: 14, Issue:5, 2018

Azilsartan reduced TNF-α and IL-1β levels, increased IL-10 levels and upregulated VEGF, FGF, KGF, and TGF-α in an oral mucositis model.
PloS one, , Volume: 10, Issue:2, 2015

The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis.
PloS one, , Volume: 10, Issue:10, 2015

Alcohol impairs the myeloid proliferative response to bacteremia in mice by inhibiting the stem cell antigen-1/ERK pathway.
Journal of immunology (Baltimore, Md. : 1950), , Feb-15, Volume: 188, Issue:4, 2012

Persistence after birth of systemic inflammation associated with umbilical cord inflammation.
Journal of reproductive immunology, , Volume: 90, Issue:2, 2011

Effect of atorvastatin on 5-fluorouracil-induced experimental oral mucositis.
Cancer chemotherapy and pharmacology, , Volume: 67, Issue:5, 2011

Microscopic polyangiitis triggered by recurrent methicillin-resistant Staphylococcus aureus bacteremia.
International urology and nephrology, , Volume: 42, Issue:3, 2010

Reduced neutrophil sequestration in lung tissue after laparoscopic lavage in a rat peritonitis model.
World journal of surgery, , Volume: 26, Issue:1, 2002

The transcriptional regulator AlgR is essential for Pseudomonas aeruginosa pathogenesis.
Infection and immunity, , Volume: 70, Issue:11, 2002

Platelet-activating factor and bacteremia-induced pulmonary hypertension.
The Journal of surgical research, , Volume: 88, Issue:2, 2000

Microvascular perfusion deficits are not a prerequisite for mucosal injury in septic rats.
The American journal of physiology, , Volume: 276, Issue:4, 1999

Neutrophil migration into the peritoneum is P-selectin dependent, but sequestration in lungs is selectin independent during peritonitis.
Shock (Augusta, Ga.), , Volume: 10, Issue:4, 1998

Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection.
American journal of respiratory and critical care medicine, , Volume: 157, Issue:3 Pt 1, 1998

Partial liquid ventilation reduces pulmonary neutrophil accumulation in an experimental model of systemic endotoxemia and acute lung injury.
Critical care medicine, , Volume: 26, Issue:10, 1998

Bioactive substance accumulation and septic complications in a burn trauma patient: effect of perioperative blood transfusion?
Burns : journal of the International Society for Burn Injuries, , Volume: 23, Issue:1, 1997

Neutralization of macrophage inflammatory protein-2 attenuates neutrophil recruitment and bacterial clearance in murine Klebsiella pneumonia.
The Journal of infectious diseases, , Volume: 173, Issue:1, 1996

Enhanced survival from cecal ligation and puncture with pentoxifylline is associated with altered neutrophil trafficking and reduced interleukin-1 beta expression but not inhibition of tumor necrosis factor synthesis.
Surgery, , Volume: 116, Issue:2, 1994

[Measurement of myeloperoxidase and thiobarbituric acid-reactive material in plasma and bronchoalveolar lavage in E. coli-induced acute lung injury].
Nihon Kyobu Shikkan Gakkai zasshi, , Volume: 31, Issue:8, 1993

Myeloperoxidase deficiency and severe sepsis.
Southern medical journal, , Volume: 86, Issue:7, 1993

Oxidative stress in skeletal muscle during sepsis in rats.
Circulatory shock, , Volume: 39, Issue:2, 1993

Patterns of primary degranulation as indicated by the mean myeloperoxidase index (MPXI) during bacteraemia in lymphoma transplants treated with growth factors.
Clinical and laboratory haematology, , Volume: 14, Issue:4, 1992

Polymicrobial sepsis disrupts normal neutrophil extracellular matrix protein interactions.
Circulatory shock, , Volume: 38, Issue:1, 1992

Burn injury exacerbates hemodynamic and metabolic responses in rats with polymicrobial sepsis.
Journal of burn care & research : official publication of the American Burn Association, , Volume: 27, Issue:1

Elevated MMP-8 and decreased myeloperoxidase concentrations associate significantly with the risk for peripheral atherosclerosis disease and abdominal aortic aneurysm.
Scandinavian journal of immunology, , Volume: 72, Issue:2, 2010

Association of serum myeloperoxidase with the ankle-brachial index and peripheral arterial disease.
Vascular medicine (London, England), , Volume: 14, Issue:3, 2009

Peripheral arterial disease enters the biomarker era. Does risk stratification tell us something that we don't already know?
European heart journal, , Volume: 29, Issue:2, 2008

Myeloperoxidase, but not C-reactive protein, predicts cardiovascular risk in peripheral arterial disease.
European heart journal, , Volume: 29, Issue:2, 2008

Omega-3 polyunsaturated fatty acid in peripheral arterial disease: effect on lipid pattern, disease severity, inflammation profile, and endothelial function.
Clinical nutrition (Edinburgh, Scotland), , Volume: 27, Issue:2, 2008

Selective activation of the prostaglandin E2 circuit in chronic injury-induced pathologic angiogenesis.
Investigative ophthalmology & visual science, , Volume: 51, Issue:12, 2010

Exacerbated corneal inflammation and neovascularization in the HO-2 null mice is ameliorated by biliverdin.
Experimental eye research, , Volume: 87, Issue:3, 2008

Inflammatory Pattern of the Bronchial Mucosa in Patients with Asthma with Airway Hyperresponsiveness to Hypoosmotic Stimulus.
Bulletin of experimental biology and medicine, , Volume: 161, Issue:4, 2016

Assessment of inhibitory potential of Pothos scandens L. on ovalbumin-induced airway hyperresponsiveness in balb/c mice.
International immunopharmacology, , Volume: 18, Issue:1, 2014

Naringin attenuates enhanced cough, airway hyperresponsiveness and airway inflammation in a guinea pig model of chronic bronchitis induced by cigarette smoke.
International immunopharmacology, , Volume: 13, Issue:3, 2012

Pituitary adenylate cyclase-activating polypeptide plays an anti-inflammatory role in endotoxin-induced airway inflammation: in vivo study with gene-deleted mice.
Peptides, , Volume: 32, Issue:7, 2011

Airway inflammation and mannitol challenge test in COPD.
Respiratory research, , Jan-18, Volume: 12, 2011

Inhibition of airway inflammation, hyperresponsiveness and remodeling by soy isoflavone in a murine model of allergic asthma.
International immunopharmacology, , Volume: 11, Issue:8, 2011

Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice.
The Journal of allergy and clinical immunology, , Volume: 120, Issue:1, 2007

Role of capsaicin-sensitive afferents and sensory neuropeptides in endotoxin-induced airway inflammation and consequent bronchial hyperreactivity in the mouse.
Regulatory peptides, , Jun-07, Volume: 141, Issue:1-3, 2007

Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2-type immune responses.
Journal of immunology (Baltimore, Md. : 1950), , Oct-01, Volume: 175, Issue:7, 2005

Exposure and immunological determinants in a murine model for toluene diisocyanate (TDI) asthma.
Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 84, Issue:1, 2005

Granulocyte depletion and dexamethasone differentially modulate airways hyperreactivity, inflammation, mucus accumulation, and secretion induced by rmIL-13 or antigen.
American journal of respiratory cell and molecular biology, , Volume: 26, Issue:1, 2002

Airway neutrophil inflammation in nonasthmatic patients with food allergy.
Allergy, , Volume: 57, Issue:5, 2002

CXCR2 is necessary for the development and persistence of chronic fungal asthma in mice.
Journal of immunology (Baltimore, Md. : 1950), , Feb-01, Volume: 168, Issue:3, 2002

CCSP modulates airway dysfunction and host responses in an Ova-challenged mouse model.
American journal of physiology. Lung cellular and molecular physiology, , Volume: 281, Issue:5, 2001

Eosinophil markers in blood, serum, and urine for monitoring the clinical course in childhood asthma: impact of budesonide treatment and withdrawal.
The Journal of allergy and clinical immunology, , Volume: 107, Issue:5, 2001

Airway administration of Escherichia coli endotoxin to mice induces glucocorticosteroid-resistant bronchoconstriction and vasopermeation.
American journal of respiratory cell and molecular biology, , Volume: 24, Issue:3, 2001

The relationship between airways inflammation and asthma severity.
American journal of respiratory and critical care medicine, , Volume: 161, Issue:1, 2000

Markers of inflammation and bronchial reactivity in children with asthma, exposed to animal dander in school dust.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, , Volume: 10, Issue:1, 1999

Serum ECP and MPO, but not urinary LTE4, are associated with bronchial hyper-responsiveness.
Respiratory medicine, , Volume: 93, Issue:8, 1999

Dose-response relationship to inhaled endotoxin in normal subjects.
American journal of respiratory and critical care medicine, , Volume: 156, Issue:4 Pt 1, 1997

Asthma, bronchial hyperreactivity and mediator release in children with birch pollinosis. ECP and EPX levels are not related to bronchial hyperreactivity.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 27, Issue:5, 1997

Immediate and delayed effects of nitrogen dioxide exposure at an ambient level on bronchial responsiveness to histamine in subjects with asthma.
The European respiratory journal, , Volume: 9, Issue:4, 1996

Inflammatory markers in childhood asthma.
Annals of medicine, , Volume: 28, Issue:5, 1996

Role of interleukin-5 and substance P in development of airway hyperreactivity to histamine in guinea-pigs.
The European respiratory journal, , Volume: 9, Issue:3, 1996

BAL neutrophilia in asthmatic patients. A by-product of eosinophil recruitment?
Chest, , Volume: 110, Issue:5, 1996

[Inhalation of platelet-activating factor induced guinea pig airway hyperresponsiveness: role of eosinophils activation].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, , Volume: 18, Issue:3, 1995

Increased PMA-induced chemiluminescence from whole blood of patients with bronchial hyperreactivity.
The European respiratory journal, , Volume: 7, Issue:8, 1994

Dissociation of airway responsiveness and bronchoalveolar lavage (BAL) cell composition in sensitized guinea-pigs after daily inhalation of ovalbumin.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 24, Issue:7, 1994

γ-Tocopherol-rich supplementation additively improves vascular endothelial function during smoking cessation.
Free radical biology & medicine, , Volume: 65, 2013

Effect of smoking cessation on airway inflammation of rats with chronic bronchitis.
Chinese medical journal, , Sep-05, Volume: 120, Issue:17, 2007

Myeloperoxidase as a marker of increasing systemic inflammation in smokers without severe airway symptoms.
Respiratory medicine, , Volume: 101, Issue:5, 2007

Differences in responses upon corticosteroid therapy between smoking and non-smoking patients with COPD.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, , Volume: 57 Suppl 4, 2006

Cerebrospinal fluid involvement in acute promyelocytic leukaemia at presentation.
BMJ case reports, , Mar-09, Volume: 2015, 2015

Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia.
Frontiers in immunology, , Volume: 13, 2022

[no title available]
Applied physics. B, Lasers and optics, , Volume: 122, Issue:12, 2016

Lactobacillus johnsonii HY7042 ameliorates Gardnerella vaginalis-induced vaginosis by killing Gardnerella vaginalis and inhibiting NF-κB activation.
International immunopharmacology, , Volume: 11, Issue:11, 2011

Artemisia princeps Pamp. Essential oil and its constituents eucalyptol and α-terpineol ameliorate bacterial vaginosis and vulvovaginal candidiasis in mice by inhibiting bacterial growth and NF-κB activation.
Planta medica, , Volume: 77, Issue:18, 2011

A quantitative evaluation of total antioxidant status and oxidative stress markers in preeclampsia and gestational diabetic patients in 24-36 weeks of gestation.
Diabetes research and clinical practice, , Volume: 89, Issue:3, 2010

Increased oxidative stress markers may be a promising indicator of risk for primary ovarian insufficiency: a cross-sectional case control study.
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, , Volume: 37, Issue:9, 2015

Neutrophil Extracellular Traps May Contribute to the Pathogenesis in Adult-onset Still Disease.
The Journal of rheumatology, , Volume: 46, Issue:12, 2019

Does searching for antineutrophil cytoplasmic antibodies help with the diagnosis of Adult-onset Still's disease?
Rheumatology international, , Volume: 33, Issue:3, 2013

Hepatitis-E-virus-associated antigen: improved detection in stools by protein Fv removal.
Research in virology, , Volume: 142, Issue:6

Comparative Cardiac Safety of Selective Serotonin Reuptake Inhibitors among Individuals Receiving Maintenance Hemodialysis.
Journal of the American Society of Nephrology : JASN, , Volume: 30, Issue:4, 2019

Myeloperoxidase is associated with incident coronary heart disease independently of traditional risk factors: results from the MONICA/KORA Augsburg study.
Journal of internal medicine, , Volume: 271, Issue:1, 2012

Myeloperoxidase and plaque vulnerability.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 24, Issue:7, 2004

Glucantime reduces mechanical hyperalgesia in cutaneous leishmaniasis and complete Freund's adjuvant models of chronic inflammatory pain.
The Journal of pharmacy and pharmacology, , Volume: 70, Issue:6, 2018

Enzymatic Mechanism of Leishmania major Peroxidase and the Critical Role of Specific Ionic Interactions.
Biochemistry, , Jun-02, Volume: 54, Issue:21, 2015

Protection against peroxynitrite by pseudoperoxidase from Leishmania major.
Free radical biology & medicine, , Nov-15, Volume: 53, Issue:10, 2012

Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors.
Immunology, , Volume: 130, Issue:2, 2010

Prevalence of malaria and associated clinical manifestations and myeloperoxidase amongst populations living in different altitudes of Mezam division, North West Region, Cameroon.
Malaria journal, , Jan-19, Volume: 22, Issue:1, 2023

Human neutrophil lipocalin: a specific marker for neutrophil activation in severe Plasmodium falciparum malaria.
Acta tropica, , Volume: 87, Issue:2, 2003

Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology.
PloS one, , Volume: 11, Issue:1, 2016

Role of MIP-2 in neutrophil migration and tissue injury in the herpes simplex virus-1-infected cornea.
Investigative ophthalmology & visual science, , Volume: 39, Issue:10, 1998

Elevated Leukocyte Azurophilic Enzymes in Human Diabetic Ketoacidosis Plasma Degrade Cerebrovascular Endothelial Junctional Proteins.
Critical care medicine, , Volume: 44, Issue:9, 2016

Relation of MPO, MnSOD, NQO1 gene variants in endometrial carcinoma in the line of PCR-RFLP methods.
Cellular and molecular biology (Noisy-le-Grand, France), , Mar-31, Volume: 64, Issue:4, 2018

[PHENOTYPE OF PERIPHERAL BLOOD NEUTROPHILS IN THE INITIAL STAGE OF ENDOMETRIAL CANCER].
Tsitologiia, , Volume: 58, Issue:1, 2016

[The plasma level of sL-selectin, myeloperoxidase (MPO) and granulocyte-colony stimulating factor (G-CSF) in gynecological cancer patients].
Przeglad lekarski, , Volume: 67, Issue:3, 2010

Switching (overtargeting) of estrogen effects and its potential role in hormonal carcinogenesis.
Neoplasma, , Volume: 49, Issue:1, 2002

Increased myeloperoxidase and lipid peroxide-modified protein in gynecological malignancies.
Antioxidants & redox signaling, , Volume: 3, Issue:6, 2001

Myeloperoxidase-antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis in autosomal dominant polycystic kidney disease.
BMC nephrology, , Apr-23, Volume: 14, 2013

Circulating levels of soluble adhesion molecules in patients with ANCA-associated vasculitis.
Journal of nephrology, , Volume: 17, Issue:6

Plasma myeloperoxidase levels in acute brain ischaemia and high grade carotid stenosis.
European journal of neurology, , Volume: 27, Issue:8, 2020

N
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 26, Issue:6, 2017

Serum levels of anti-apolipoprotein A-1 auto-antibodies and myeloperoxidase as predictors of major adverse cardiovascular events after carotid endarterectomy.
Thrombosis and haemostasis, , Volume: 109, Issue:4, 2013

Clinical significance of active myeloperoxidase in carotid atherosclerotic plaques.
International journal of cardiology, , Oct-06, Volume: 152, Issue:1, 2011

Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 26, Issue:12, 2006

Myeloperoxidase predicts progression of carotid stenosis in states of low high-density lipoprotein cholesterol.
Journal of the American College of Cardiology, , Jun-06, Volume: 47, Issue:11, 2006

Adherent/invasive capacities of bovine-associated Aerococcus viridans contribute to pathogenesis of acute mastitis in a murine model.
Veterinary microbiology, , Volume: 230, 2019

Topical application of phenolic compounds suppresses Propionibacterium acnes-induced inflammatory responses in mice with ear edema.
Naunyn-Schmiedeberg's archives of pharmacology, , Volume: 392, Issue:5, 2019

The SKPO-1 peroxidase functions in the hypodermis to protect Caenorhabditis elegans from bacterial infection.
Genetics, , Volume: 197, Issue:2, 2014

Five-year longitudinal assessment (2008 to 2012) of E-101 solution activity against clinical target and antimicrobial-resistant pathogens.
Antimicrobial agents and chemotherapy, , Volume: 58, Issue:8, 2014

Characterization of S. pneumoniae pneumonia-induced multiple organ dysfunction syndrome: an experimental mouse model of gram-positive sepsis.
Shock (Augusta, Ga.), , Volume: 31, Issue:4, 2009

A role for tumor necrosis factor-alpha in experimental Bacillus cereus endophthalmitis pathogenesis.
Investigative ophthalmology & visual science, , Volume: 49, Issue:10, 2008

Knockout of Mkp-1 enhances the host inflammatory responses to gram-positive bacteria.
Journal of immunology (Baltimore, Md. : 1950), , Apr-15, Volume: 178, Issue:8, 2007

Positive bacterial culture of semen from infertile men with asymptomatic leukocytospermia.
International journal of fertility and women's medicine, , Volume: 47, Issue:6

Anti-lactoferrin antibodies and other types of anti-neutrophil cytoplasmic antibodies (ANCA) in reactive arthritis and ankylosing spondylitis.
Clinical and experimental immunology, , Volume: 117, Issue:3, 1999

Beta-thromboglobulin in inflammatory synovial fluid.
Inflammation, , Volume: 7, Issue:4, 1983

Contribution of the myeloperoxidase-dependent oxidative system to host defence against Cryptococcus neoformans.
Journal of medical microbiology, , Volume: 55, Issue:Pt 9, 2006

[An elderly case of ANCA-positive membranous nephropathy].
Nihon Jinzo Gakkai shi, , Volume: 44, Issue:1, 2002

The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood.
Mediators of inflammation, , Volume: 2019, 2019

Oxidative stress, cytokine/chemokine and disruption of blood-brain barrier in neonate rats after meningitis by Streptococcus agalactiae.
Neurochemical research, , Volume: 36, Issue:10, 2011

Oxidative stress and myeloperoxidase activity during bacterial meningitis: effects of febrile episodes and the BBB permeability.
Clinical biochemistry, , Volume: 43, Issue:3, 2010

Mercaptoethylguanidine attenuates inflammation in bacterial meningitis in rabbits.
Life sciences, , Jun-16, Volume: 67, Issue:4, 2000

Integrin expression on neutrophils in a rabbit model of Group B Streptococcal meningitis.
Inflammation, , Volume: 24, Issue:2, 2000

Hypothermia as an adjunctive treatment for severe bacterial meningitis.
Brain research, , Oct-20, Volume: 881, Issue:1, 2000

Common variable immunodeficiency patients display elevated plasma levels of granulocyte activation markers elastase and myeloperoxidase.
International journal of immunopathology and pharmacology, , Volume: 33

Increased expression of toll-like receptor 4 enhances endotoxin-induced hepatic failure in partially hepatectomized mice.
Journal of hepatology, , Volume: 41, Issue:4, 2004

Mice lacking inducible nitric oxide synthase show strong resistance to anti-Fas antibody-induced fulminant hepatitis.
Archives of biochemistry and biophysics, , Mar-01, Volume: 411, Issue:1, 2003

Generation of neutrophil extracellular traps in patients with acute liver failure is associated with poor outcome.
Hepatology (Baltimore, Md.), , Volume: 75, Issue:3, 2022

Mesenchymal stem cells increase expression of heme oxygenase-1 leading to anti-inflammatory activity in treatment of acute liver failure.
Stem cell research & therapy, , 03-20, Volume: 8, Issue:1, 2017

Methylprednisolone prevents bacterial translocation in thioacetamide-induced liver failure in rats.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, , Volume: 28, Issue:5, 2017

Endoplasmic reticulum stress-activated glycogen synthase kinase 3β aggravates liver inflammation and hepatotoxicity in mice with acute liver failure.
Inflammation, , Volume: 38, Issue:3, 2015

Protective effect of oroxylin A against lipopolysaccharide and/or D-galactosamine-induced acute liver injury in mice.
The Journal of surgical research, , May-15, Volume: 195, Issue:2, 2015

Chymase inhibition attenuates lipopolysaccharide/ d-galactosamine-induced acute liver failure in hamsters.
Pharmacology, , Volume: 93, Issue:1-2, 2014

Synthetic RGDS peptide attenuated lipopolysaccharide/D-galactosamine-induced fulminant hepatic failure in mice.
Journal of gastroenterology and hepatology, , Volume: 29, Issue:6, 2014

Effect of methylsulfonylmethane on paraquat-induced acute lung and liver injury in mice.
Inflammation, , Volume: 36, Issue:5, 2013

Reduction of acute hepatic damage induced by acetaminophen after treatment with diphenyl diselenide in mice.
Toxicologic pathology, , Volume: 40, Issue:4, 2012

Tetrandrine attenuates lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice.
International immunopharmacology, , Volume: 10, Issue:3, 2010

[The role of oxidative stress and arterial blood supply in the transplanted liver function].
Orvosi hetilap, , Nov-09, Volume: 144, Issue:45, 2003

Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo.
Journal of pineal research, , Volume: 33, Issue:2, 2002

Probiotics-pathogen interactions elicit differential regulation of cutaneous immune responses in epidermal cells of Atlantic cod Gadus morhua.
Fish & shellfish immunology, , Volume: 36, Issue:1, 2014

Associations between myeloperoxidase and paraoxonase-1 and type 2 diabetes in patients with ischemic heart disease.
BMC cardiovascular disorders, , 12-03, Volume: 22, Issue:1, 2022

Integrated Metabolomics and Network Pharmacology to Reveal the Mechanisms of Guizhi-Fuling Treatment for Myocardial Ischemia.
Chemistry & biodiversity, , Volume: 19, Issue:10, 2022

Vildagliptin Recruits Regulatory T Cells in Patients Undergoing Primary Percutaneous Coronary Intervention.
Immunological investigations, , Volume: 47, Issue:6, 2018

Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions.
Free radical biology & medicine, , Volume: 90, 2016

Puerarin attenuates severe burn-induced acute myocardial injury in rats.
Burns : journal of the International Society for Burn Injuries, , Volume: 41, Issue:8, 2015

Anti-Fibrotic Effects of Class I HDAC Inhibitor, Mocetinostat Is Associated with IL-6/Stat3 Signaling in Ischemic Heart Failure.
International journal of molecular sciences, , May-19, Volume: 16, Issue:5, 2015

Increased plasma high-sensitivity C-reactive protein and myeloperoxidase levels may predict ischemia during myocardial perfusion imaging in slow coronary flow.
Archives of medical research, , Volume: 45, Issue:1, 2014

Toll-like receptor 9-activation during onset of myocardial ischemia does not influence infarct extension.
PloS one, , Volume: 9, Issue:8, 2014

Role of serum myeloperoxidase, CPK, CK-MB, and cTnI tests in early diagnosis of myocardial ischemia during ERCP.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, , Volume: 25, Issue:3, 2014

Author's reply: To PMID 25141318.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, , Volume: 25, Issue:4, 2014

Serum myeloperoxidase, CPK, CK-MB, and cTnI levels in early diagnosis of myocardial ischemia during ERCP; once or repeated once?
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, , Volume: 25, Issue:4, 2014

Role of CC-chemokine receptor 5 on myocardial ischemia-reperfusion injury in rats.
Molecular and cellular biochemistry, , Volume: 378, Issue:1-2, 2013

Significance of the neutrophil myeloperoxidase index in patients with atherosclerotic diseases.
The Kobe journal of medical sciences, , Mar-13, Volume: 58, Issue:5, 2013

Chronoamperometric magneto immunosensor for myeloperoxidase detection in human plasma based on a magnetic switch produced by 3D laser sintering.
Analytical chemistry, , Oct-01, Volume: 85, Issue:19, 2013

Adora2b signaling on bone marrow derived cells dampens myocardial ischemia-reperfusion injury.
Anesthesiology, , Volume: 116, Issue:6, 2012

Low-level exposure to ambient particulate matter is associated with systemic inflammation in ischemic heart disease patients.
Environmental research, , Volume: 116, 2012

[The intracellular metabolism of neutrophils under different forms of ischemic heart disease].
Klinicheskaia laboratornaia diagnostika, , Issue:12, 2012

[The detection of myeloperoxidase in case of surgical treatment of ischemic heart disease].
Klinicheskaia laboratornaia diagnostika, , Issue:7, 2012

Serum myeloperoxidase is independent of the risk factors of atherosclerosis.
Coronary artery disease, , Volume: 23, Issue:4, 2012

Myeloperoxidase improves risk stratification in patients with ischemia and normal cardiac troponin I concentrations.
Clinical chemistry, , Volume: 57, Issue:4, 2011

Effects of des-aspartate-angiotensin I on myocardial ischemia-reperfusion injury in rats.
European journal of pharmacology, , May-11, Volume: 658, Issue:2-3, 2011

Nonanticoagulant heparin reduces myocyte Na+ and Ca2+ loading during simulated ischemia and decreases reperfusion injury.
American journal of physiology. Heart and circulatory physiology, , Volume: 298, Issue:1, 2010

Postischemia myocardial injury in coronary artery bypass patients (PP6).
Transplantation proceedings, , Volume: 42, Issue:3, 2010

Cardiac: is this biomarker ready for the prime time?
Scandinavian journal of clinical and laboratory investigation. Supplementum, , Volume: 242, 2010

Lactoferrin is a novel predictor of fatal ischemic heart disease in diabetes mellitus type 2: long-term follow-up of the HUNT 1 study.
Atherosclerosis, , Volume: 212, Issue:2, 2010

Increases in myeloperoxidase levels after exercise in myocardial perfusion scintigraphy are not induced by myocardial ischemia.
Clinica chimica acta; international journal of clinical chemistry, , Volume: 395, Issue:1-2, 2008

[Age changes redox regulation metabolism and antioxidative protection of neutrophils in patients with ischemic heart disease].
Advances in gerontology = Uspekhi gerontologii, , Volume: 21, Issue:3, 2008

Myeloperoxidase: a new biomarker of inflammation in ischemic heart disease and acute coronary syndromes.
Mediators of inflammation, , Volume: 2008, 2008

Gadolinium chloride attenuates aortic occlusion-reperfusion-induced myocardial injury in rats.
Saudi medical journal, , Volume: 28, Issue:3, 2007

Activation of polymorphonuclear neutrophils in patients with impaired left ventricular function.
Free radical biology & medicine, , Oct-15, Volume: 43, Issue:8, 2007

Nitric oxide inhalation improves microvascular flow and decreases infarction size after myocardial ischemia and reperfusion.
Journal of the American College of Cardiology, , Aug-21, Volume: 50, Issue:8, 2007

[Clinical implications of relationship between myeloperoxidase and acute coronary syndromes].
Zhonghua xin xue guan bing za zhi, , Volume: 35, Issue:3, 2007

Infiltration of polymorphonuclear cells into the post-ischaemic myocardium is dependent on beta2 and alpha4 integrins.
International journal of experimental pathology, , Volume: 88, Issue:4, 2007

Asymmetric dimethyl L-arginine (ADMA) is a critical regulator of myocardial reperfusion injury.
Cardiovascular research, , Jul-15, Volume: 75, Issue:2, 2007

[Antioxidative defense in patients with acute coronary syndrome and concomitant type 2 diabetes and its modification by lisinopril].
Kardiologiia, , Volume: 45, Issue:8, 2005

Reduction of myocardial infarct size by doxycycline: a role for plasmin inhibition.
Molecular and cellular biochemistry, , Volume: 270, Issue:1-2, 2005

Oral pre-treatment with rosuvastatin protects porcine myocardium from ischaemia/reperfusion injury via a mechanism related to nitric oxide but not to serum cholesterol level.
Acta physiologica Scandinavica, , Volume: 183, Issue:2, 2005

Using biomarkers to assess risk and consider treatment strategies in non-ST-segment elevation acute coronary syndromes.
Current cardiology reports, , Volume: 7, Issue:4, 2005

[Lisinopril-induced changes in antioxidant defense in patients with acute coronary syndrome and concomitant diabetes mellitus type 2].
Terapevticheskii arkhiv, , Volume: 77, Issue:12, 2005

Attenuation of post-ischemia reperfusion injury by thaliporphine and morphine in rat hearts.
Journal of biomedical science, , Volume: 12, Issue:4, 2005

Retroinfusion of embryonic endothelial progenitor cells attenuates ischemia-reperfusion injury in pigs: role of phosphatidylinositol 3-kinase/AKT kinase.
Circulation, , Aug-30, Volume: 112, Issue:9 Suppl, 2005

Effect of ischaemic preconditioning on regional release of inflammatory markers.
Clinical science (London, England : 1979), , Volume: 109, Issue:3, 2005

Markers for early detection of cardiac diseases.
Scandinavian journal of clinical and laboratory investigation. Supplementum, , Volume: 240, 2005

Overexpression of human copper/zinc superoxide dismutase (SOD1) suppresses ischemia-reperfusion injury and subsequent development of graft coronary artery disease in murine cardiac grafts.
Circulation, , Sep-14, Volume: 110, Issue:11 Suppl 1, 2004

Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts.
Circulation, , Sep-14, Volume: 110, Issue:11 Suppl 1, 2004

Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion.
Cardiovascular research, , Apr-01, Volume: 62, Issue:1, 2004

Markers to define ischemia: are they ready for prime time use in patients with acute coronary syndromes?
Current cardiology reports, , Volume: 6, Issue:4, 2004

Myeloperoxidase enhances nitric oxide catabolism during myocardial ischemia and reperfusion.
Free radical biology & medicine, , Sep-15, Volume: 37, Issue:6, 2004

Roles of ischemia and hypoxia and the molecular pathogenesis of post-burn cardiac shock.
Burns : journal of the International Society for Burn Injuries, , Volume: 29, Issue:8, 2003

FR183998, a Na+/H+ exchange inhibitor, suppresses both IL-8 content and myocardial infarct size in a cardiac ischaemia-reperfusion model in rats.
The Journal of pharmacy and pharmacology, , Volume: 54, Issue:2, 2002

Development of an in vivo ischemia-reperfusion model in heterotopically transplanted rat hearts.
Transplantation, , May-15, Volume: 73, Issue:9, 2002

Delivery of a non-potassium modified maintenance solution to enhance myocardial protection in stressed neonatal hearts: a new approach.
The Journal of thoracic and cardiovascular surgery, , Volume: 123, Issue:1, 2002

Oxygen radicals trigger activation of NF-kappaB and AP-1 and upregulation of ICAM-1 in reperfused canine heart.
American journal of physiology. Heart and circulatory physiology, , Volume: 282, Issue:5, 2002

The isolated blood-perfused rat heart: an inappropriate model for the study of ischaemia- and infarction-related ventricular fibrillation.
British journal of pharmacology, , Volume: 137, Issue:7, 2002

Widespread coronary inflammation in unstable angina.
The New England journal of medicine, , Jul-04, Volume: 347, Issue:1, 2002

Cardioprotective effects of the serine protease inhibitor aprotinin after regional ischemia and reperfusion on the beating heart.
The Journal of thoracic and cardiovascular surgery, , Volume: 124, Issue:5, 2002

Xanthine oxidase, but not neutrophils, contributes to activation of cardiac sympathetic afferents during myocardial ischaemia in cats.
The Journal of physiology, , Aug-15, Volume: 543, Issue:Pt 1, 2002

Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo.
Journal of pineal research, , Volume: 33, Issue:2, 2002

Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo.
British journal of pharmacology, , Volume: 136, Issue:6, 2002

Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury.
Circulation, , Sep-18, Volume: 104, Issue:12, 2001

The nitroderivative of aspirin, NCX 4016, reduces infarct size caused by myocardial ischemia-reperfusion in the anesthetized rat.
The Journal of pharmacology and experimental therapeutics, , Volume: 297, Issue:1, 2001

Intestinal ischemia induces late preconditioning against myocardial infarction: a role for inducible nitric oxide synthase.
Cardiovascular research, , Feb-01, Volume: 49, Issue:2, 2001

Blockade of the natriuretic peptide receptor guanylyl cyclase-A inhibits NF-kappaB activation and alleviates myocardial ischemia/reperfusion injury.
The Journal of clinical investigation, , Volume: 108, Issue:2, 2001

Magnolol reduces myocardial ischemia/reperfusion injury via neutrophil inhibition in rats.
European journal of pharmacology, , Jun-22, Volume: 422, Issue:1-3, 2001

Peroxynitrite, a two-edged sword in post-ischemic myocardial injury-dichotomy of action in crystalloid- versus blood-perfused hearts.
The Journal of pharmacology and experimental therapeutics, , Volume: 292, Issue:3, 2000

Myocardial neutrophil sequestration during reperfusion of the transplanted rabbit heart.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, , Volume: 19, Issue:8, 2000

Na(+)/H(+) exchange inhibition-induced cardioprotection in dogs: effects on neutrophils versus cardiomyocytes.
American journal of physiology. Heart and circulatory physiology, , Volume: 279, Issue:4, 2000

Comparison of bisoprolol and carvedilol cardioprotection in a rabbit ischemia and reperfusion model.
European journal of pharmacology, , Oct-06, Volume: 406, Issue:1, 2000

Tacrolimus limits polymorphonuclear leucocyte accumulation and protects against myocardial ischaemia- reperfusion injury.
Journal of molecular and cellular cardiology, , Volume: 32, Issue:3, 2000

Amelioration by quinapril of myocardial infarction induced by coronary occlusion/reperfusion in a rabbit model of atherosclerosis: possible mechanisms.
Circulation, , Jan-26, Volume: 99, Issue:3, 1999

Cardioprotection by the phytoestrogen genistein in experimental myocardial ischaemia-reperfusion injury.
British journal of pharmacology, , Volume: 128, Issue:8, 1999

A Na+-H+ exchange inhibitor (SM-20550) protects from microvascular deterioration and myocardial injury after reperfusion.
European journal of pharmacology, , Jun-25, Volume: 374, Issue:3, 1999

Nitecapone inhibits myeloperoxidase in vitro and enhances functional performance after 8 h of ischemia in experimental heart transplantation.
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, , Volume: 198, Issue:6, 1999

Cloricromene reduces infarct size and alters postischaemic blood flow defects in dog myocardium.
Clinical and experimental pharmacology & physiology, , Volume: 25, Issue:6, 1998

Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti-C5 therapy.
Circulation, , Jun-09, Volume: 97, Issue:22, 1998

Synergism between platelets and neutrophils in provoking cardiac dysfunction after ischemia and reperfusion: role of selectins.
Circulation, , Sep-29, Volume: 98, Issue:13, 1998

Effect of the platelet-activating factor antagonist RP 59227 (Tulopafant) on myocardial ischemia/reperfusion injury and neutrophil function.
Basic research in cardiology, , Volume: 93, Issue:5, 1998

Beneficial effect of raxofelast, an hydrophilic vitamin E analogue, in the rat heart after ischemia and reperfusion injury.
Journal of molecular and cellular cardiology, , Volume: 30, Issue:8, 1998

Attenuation of interleukin-8 expression in C6-deficient rabbits after myocardial ischemia/reperfusion.
Journal of molecular and cellular cardiology, , Volume: 30, Issue:1, 1998

Effects of a monoclonal antibody to P-selectin on recovery of neonatal lamb hearts after cold cardioplegic ischemia.
Circulation, , Nov-10, Volume: 98, Issue:19 Suppl, 1998

Comparison of metoprolol and carvedilol pharmacology and cardioprotection in rabbit ischemia and reperfusion model.
European journal of pharmacology, , Jun-26, Volume: 351, Issue:3, 1998

Formation of nitric oxide, superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury in rats.
The American journal of physiology, , Volume: 272, Issue:5 Pt 2, 1997

[Activation of the antibacterial properties and neutrophil myeloperoxidase and acid phosphatase in patients with unstable angina pectoris].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, , Volume: 3, Issue:13, 1997

Myocardial protection by the leukotriene synthesis inhibitor BAY X1005: importance of transcellular biosynthesis of cysteinyl-leukotrienes.
The Journal of pharmacology and experimental therapeutics, , Volume: 276, Issue:1, 1996

Intracellular neutrophil myeloperoxidase is reduced in unstable angina and acute myocardial infarction, but its reduction is not related to ischemia.
Journal of the American College of Cardiology, , Mar-01, Volume: 27, Issue:3, 1996

Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation.
The Journal of pharmacology and experimental therapeutics, , Volume: 277, Issue:1, 1996

Preservation of global cardiac function in the rabbit following protracted ischemia/reperfusion using monophosphoryl lipid A (MLA).
Journal of molecular and cellular cardiology, , Volume: 28, Issue:1, 1996

An oligosaccharide sialyl-Lewis(x) analogue does not reduce myocardial infarct size after ischemia and reperfusion in dogs.
Circulation, , Aug-01, Volume: 94, Issue:3, 1996

A study of time window for oxidative stress associated with myocardial ischemia and reperfusion.
Chinese medical journal, , Volume: 109, Issue:12, 1996

Limitation of myocardial infarct size by nicorandil after sustained ischemia in pigs.
Journal of cardiovascular pharmacology, , Volume: 26, Issue:3, 1995

Limitation of reperfusion injury by a monoclonal antibody to C5a during myocardial infarction in pigs.
The American journal of physiology, , Volume: 268, Issue:1 Pt 2, 1995

Myocardial neutrophil infiltration, lipid peroxidation, and antioxidant activity after coronary artery thrombosis and thrombolysis.
American heart journal, , Volume: 129, Issue:2, 1995

Effects of BMY21190, an inhibitor of cAMP phosphodiesterase, on infarct size and myeloperoxidase activity in the ischemic myocardium of a canine occlusion-reperfusion model.
Pharmacology, , Volume: 50, Issue:1, 1995

Cardioprotection by liposome-conjugated sialyl Lewisx-oligosaccharide in myocardial ischaemia and reperfusion injury.
Cardiovascular research, , Volume: 30, Issue:6, 1995

Cardioprotective effects of selective inhibition of the two complement activation pathways in myocardial ischemia and reperfusion injury.
Methods and findings in experimental and clinical pharmacology, , Volume: 17, Issue:8, 1995

Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit. Evidence for a role for C5a and interleukin-8.
The Journal of clinical investigation, , Volume: 95, Issue:6, 1995

Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil function in dogs.
Circulation, , Sep-01, Volume: 92, Issue:5, 1995

Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion.
Proceedings of the National Academy of Sciences of the United States of America, , Aug-15, Volume: 92, Issue:17, 1995

Attenuation of coronary flow reserve and myocardial function after temporary subtotal coronary artery occlusion and increased myocardial oxygen demand in dogs.
Journal of the American College of Cardiology, , Volume: 24, Issue:3, 1994

Adenosine blockade during reperfusion reverses the infarct limiting effect in preconditioned canine hearts.
Cardiovascular research, , Volume: 28, Issue:7, 1994

Ebselen protects against ischemia-reperfusion injury in a canine model of myocardial infarction.
The American journal of physiology, , Volume: 267, Issue:6 Pt 2, 1994

Protective effects of L-659,989, a platelet-activating factor receptor antagonist, in myocardial ischemia and reperfusion in rats.
Journal of cardiovascular pharmacology, , Volume: 23, Issue:1, 1994

Platelet activating factor interaction with tumor necrosis factor in myocardial ischaemia-reperfusion injury.
Journal of lipid mediators, , Volume: 8, Issue:1, 1993

Leukocyte depletion in a neonatal model of cardiac surgery.
The Annals of thoracic surgery, , Volume: 55, Issue:1, 1993

Reduction of myocardial leukocyte accumulation and myocardial infarct size following administration of BAY u3405, a thromboxane A2 receptor antagonist, in myocardial ischaemia-reperfusion injury.
Agents and actions, , Volume: 39, Issue:3-4, 1993

Effects of monophosphoryl lipid A on myocardial ischemia/reperfusion injury in dogs.
Journal of cardiovascular pharmacology, , Volume: 22, Issue:4, 1993

Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion of dogs.
Circulation, , Volume: 88, Issue:5 Pt 1, 1993

Dissociation of the anti-ischaemic effects of cloricromene from its anti-platelet activity.
British journal of pharmacology, , Volume: 110, Issue:1, 1993

[Tumor necrosis factor in myocardial ischemia and reperfusion].
Cardiologia (Rome, Italy), , Volume: 38, Issue:1, 1993

[Increased myelopepoxidase activity is a risk factor for ishemic heart disease in patients with diabetes mellitus].
Biomeditsinskaia khimiia, , Volume: 58, Issue:4

Free radical scavenger mechanisms in experimentally induced ischemia in the rabbit heart and protective effect of verapamil.
Archives internationales de pharmacodynamie et de therapie, , Volume: 318

Granulocyte accumulation in ischemic/reperfused myocardium: assessment with a technetium-99m-labeled antigranulocyte monoclonal antibody in the dog.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, , Volume: 6, Issue:6

Lymphatic diversion prevents myocardial edema following mesenteric ischemia/reperfusion.
Microcirculation (New York, N.Y. : 1994), , Volume: 11, Issue:1

[Simulation of parameters of alcohol-oxidizing enzyme systems and pathomorphological characteristics in situations of acute ethanol poisoning and ischemic heart disease].
Sudebno-meditsinskaia ekspertiza, , Volume: 54, Issue:4

Neutrophil extracellular traps activate lung fibroblast to induce polymyositis-related interstitial lung diseases via TLR9-miR-7-Smad2 pathway.
Journal of cellular and molecular medicine, , Volume: 24, Issue:2, 2020

High- density lipoprotein function is abnormal in idiopathic inflammatory myopathies.
Rheumatology (Oxford, England), , 11-01, Volume: 59, Issue:11, 2020

Immunoglobulin isotypes of anti-myeloperoxidase and anti-lactoferrin antibodies in patients with collagen diseases.
Journal of clinical immunology, , Volume: 20, Issue:4, 2000

Nuclear transcription factor-kappa beta-dependent ultrastructural alterations within the placenta and systemic inflammatory activation in pregnant patients with hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndrome: a case-control
Hypertension in pregnancy, , Volume: 32, Issue:3, 2013

Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes.
Cardiovascular research, , 01-29, Volume: 118, Issue:2, 2022

Pharmacological myeloperoxidase (MPO) inhibition in an obese/hypertensive mouse model attenuates obesity and liver damage, but not cardiac remodeling.
Scientific reports, , 12-10, Volume: 9, Issue:1, 2019

[Simultaneous presence of antibodies against the glomerular basement membrane and anti-myeloperoxidase antibodies in 2 patients with rapidly progressive glomerulonephritis].
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, , Volume: 22, Issue:2, 2002

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis.
Journal of visualized experiments : JoVE, , 09-26, Issue:187, 2022

Neutrophil-Derived Myeloperoxidase Facilitates Both the Induction and Elicitation Phases of Contact Hypersensitivity.
Frontiers in immunology, , Volume: 11, 2020

Percutaneous toxicity of dinitrochlorobenzene (DNCB) in rats.
Cutaneous and ocular toxicology, , Volume: 31, Issue:1, 2012

The incorporation of lysine into the peroxidase peptide reactivity assay for skin sensitization assessments.
Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 122, Issue:2, 2011

Effect of orally administered Eriobotrya japonica seed extract on allergic contact dermatitis in rats.
The Journal of pharmacy and pharmacology, , Volume: 59, Issue:10, 2007

Lipoxygenase-catalyzed polymerization of phenolic lipids suggests a new mechanism for allergic contact dermatitis induced by urushiol and its analogs.
Biochemical and biophysical research communications, , Mar-12, Volume: 315, Issue:3, 2004

Topical methimazole as a new treatment for postinflammatory hyperpigmentation: report of the first case.
Dermatology (Basel, Switzerland), , Volume: 211, Issue:4, 2005

Peroxidase-mediated mechanisms are involved in the melanocytotoxic and melanogenesis-inhibiting effects of chemical agents.
Dermatology (Basel, Switzerland), , Volume: 205, Issue:4, 2002

Identifying key components and therapeutic targets of the immune system in hidradenitis suppurativa with an emphasis on neutrophils.
The British journal of dermatology, , Volume: 184, Issue:6, 2021

A case of myeloperoxidase-antineutrophil cytoplasmic antibody and anticardiolipin antibody-positive pyogenic arthritis, pyoderma gangrenosum, acne and hidradenitis suppurativa (PAPASH) syndrome with colitis.
Modern rheumatology case reports, , Volume: 5, Issue:2, 2021

The Role of Inflammation and Myeloperoxidase-Related Oxidative Stress in the Pathogenesis of Genetically Triggered Thoracic Aortic Aneurysms.
International journal of molecular sciences, , Oct-16, Volume: 21, Issue:20, 2020

The inflammatory response to stent grafting of the thoracic aorta.
International angiology : a journal of the International Union of Angiology, , Volume: 26, Issue:3, 2007

Mechanism of complement activation and its role in the inflammatory response after thoracoabdominal aortic aneurysm repair.
Circulation, , Aug-19, Volume: 108, Issue:7, 2003

New insights into the molecular pathology of radiation-induced pneumopathy.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, , Volume: 101, Issue:1, 2011

Mimicking the mimicker: Necrotizing sarcoid granulomatosis.
The American journal of the medical sciences, , Volume: 364, Issue:4, 2022

Use of discriminant analysis in assessing pulmonary function worsening in patients with sarcoidosis by a panel of inflammatory biomarkers.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 62, Issue:3, 2013

Potential etiologic agents in sarcoidosis.
Proceedings of the American Thoracic Society, , Aug-15, Volume: 4, Issue:5, 2007

Serum Fetuin-A levels, insulin resistance and oxidative stress in women with polycystic ovary syndrome.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, , Volume: 29, Issue:12, 2013

Association of single nucleotide polymorphisms in MPO and COX genes with oral lichen planus.
International journal of immunogenetics, , Volume: 42, Issue:3, 2015

Releasability of human hypereosinophilic eosinophils is related to the density of the cells.
British journal of haematology, , Volume: 86, Issue:1, 1994

Expression of lacto-N-fucopentaose III (CD15)- and sialyl-Lewis X-bearing molecules and their functional properties in eosinophils from patients with the idiopathic hypereosinophilic syndrome.
Immunology, , Volume: 83, Issue:2, 1994

Induction of myeloperoxidase and nitrotyrosine formation in a human eosinophilic leukemia cell line, EoL-1.
Cell biochemistry and function, , Volume: 22, Issue:2

Systemic cholesterol embolization syndrome associated with myeloperoxidase-anti-neutrophil cytoplasmic antibody.
Internal medicine (Tokyo, Japan), , Volume: 45, Issue:8, 2006

An unusual case of ANCA positive disease.
Annals of the rheumatic diseases, , Volume: 62, Issue:8, 2003

Pauci-immune extracapillary glomerulonephritis and atheromatous embolization.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 40, Issue:4, 2002

Cholesterol embolism associated with MPO-ANCA.
European journal of dermatology : EJD, , Volume: 20, Issue:4

Network Analysis of MPO and Other Relevant Proteins Involved in Diabetic Foot Ulcer and Other Diabetic Complications.
Interdisciplinary sciences, computational life sciences, , Volume: 11, Issue:2, 2019

A Case of ALK+ Anaplastic Large-Cell Lymphoma With Aberrant Myeloperoxidase Expression and Initial Cutaneous Presentation.
The American Journal of dermatopathology, , Volume: 40, Issue:7, 2018

[Ki-1 lymphoma of the skin in a patient with Crohn's disease undergoing treatment with azathioprine].
Gastroenterologia y hepatologia, , Volume: 24, Issue:5, 2001

Granulocytic sarcoma with expression of CD30.
Journal of clinical pathology, , Volume: 49, Issue:9, 1996

Serum oxidant/antioxidant balance in exfoliation syndrome.
Clinical & experimental ophthalmology, , Volume: 33, Issue:1, 2005

Visual detection of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis strains by use of an asymmetrically split peroxidase DNAzyme.
Journal of clinical microbiology, , Volume: 50, Issue:11, 2012

Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activities.
Protein science : a publication of the Protein Society, , Volume: 19, Issue:3, 2010

Fortifying Butterfat with Soybean Oil Attenuates the Onset of Diet-Induced Non-Alcoholic Steatohepatitis and Glucose Intolerance.
Nutrients, , Mar-16, Volume: 13, Issue:3, 2021

Association of novel metrics of particulate matter with vascular markers of inflammation and coagulation in susceptible populations -results from a panel study.
Environmental research, , Volume: 150, 2016

Neutrophil infiltration and activation in bronchiolitic airways are independent of viral etiology.
Pediatric pulmonology, , Volume: 52, Issue:2, 2017

Human and Mouse Eosinophils Have Antiviral Activity against Parainfluenza Virus.
American journal of respiratory cell and molecular biology, , Volume: 55, Issue:3, 2016

A comparison of the avidin-biotin-peroxidase complex (ABC) and peroxidase-anti-peroxidase (PAP) immunocytochemical techniques for demonstrating Sendai virus infection in fixed tissue specimens.
Laboratory animal science, , Volume: 34, Issue:3, 1984

Myeloperoxidase promotor polymorphism and risk of hepatoblastoma.
International journal of cancer, , Aug-20, Volume: 106, Issue:2, 2003

A case of rhabdomyosarcoma masquerading as acute leukemia at presentation: a case report.
Indian journal of pathology & microbiology, , Volume: 50, Issue:4, 2007

Occult deposition of eosinophil peroxidase in a subset of human breast carcinomas.
The American journal of pathology, , Volume: 148, Issue:3, 1996

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma.
International journal of molecular sciences, , Jan-28, Volume: 21, Issue:3, 2020

[Granulocytic sarcoma of uterine cervix: report of a case].
Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 39, Issue:11, 2010

Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , Volume: 11, Issue:12, 2002

Myeloperoxidase (MPO) genotype and lung cancer histologic types: the MPO -463 A allele is associated with reduced risk for small cell lung cancer in smokers.
International journal of cancer, , Dec-10, Volume: 102, Issue:5, 2002

[Immunohistochemical diagnosis by means of tyramide signal amplification].
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, , Jan-20, Volume: 120, Issue:2, 2000

Carbohydrate-binding proteins (plant/human lectins and autoantibodies from human serum) as mediators of release of lysozyme, elastase, and myeloperoxidase from human neutrophils.
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, , Volume: 195, Issue:3, 1995

Improved antigen detection in ethanol-fixed cytologic specimens. A modified avidin-biotin-peroxidase complex (ABC) method.
Diagnostic cytopathology, , Volume: 1, Issue:2

Long, relapsing, and atypical symptomatic course of COVID-19 in a B-cell-depleted patient after rituximab.
Seminars in arthritis and rheumatism, , Volume: 50, Issue:5, 2020

Neutrophil extracellular traps in COVID-19.
JCI insight, , 06-04, Volume: 5, Issue:11, 2020

Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome.
Blood, , 09-03, Volume: 136, Issue:10, 2020

Streptococcus pneumoniae serotype 22F infection in respiratory syncytial virus infected neonatal lambs enhances morbidity.
PloS one, , Volume: 16, Issue:3, 2021

An in vitro transepithelial migration assay to evaluate the role of neutrophils in Respiratory Syncytial Virus (RSV) induced epithelial damage.
Scientific reports, , 04-30, Volume: 8, Issue:1, 2018

Neutrophil infiltration and activation in bronchiolitic airways are independent of viral etiology.
Pediatric pulmonology, , Volume: 52, Issue:2, 2017

Pulmonary matrix metalloproteinase-9 activity in mechanically ventilated children with respiratory syncytial virus.
The European respiratory journal, , Volume: 43, Issue:4, 2014

Decreased bacterial clearance from the lungs of mice following primary respiratory syncytial virus infection.
Journal of medical virology, , Volume: 78, Issue:6, 2006

Relationship between atopic status and nasal interleukin 10 and 11 levels in infants with respiratory syncytial virus bronchiolitis.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, , Volume: 94, Issue:2, 2005

Respiratory syncytical virus-induced chemokine expression in the lower airways: eosinophil recruitment and degranulation.
American journal of respiratory and critical care medicine, , Volume: 159, Issue:6, 1999

Immunological responses to respiratory syncytial virus infection in infancy.
Archives of disease in childhood, , Volume: 76, Issue:3, 1997

Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy.
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The acute-phase response and serum amyloid A inhibit the inflammatory response to Acinetobacter baumannii Pneumonia.
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Anti-inflammatory effects of inhaled nitric oxide are optimized at lower oxygen concentration in experimental Klebsiella pneumoniae pneumonia.
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[A case of MPO-ANCA-related microscopic polyangiitis with mixed cryoglobulinemia].
Nihon Jinzo Gakkai shi, , Volume: 48, Issue:4, 2006

A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection.
Genes and immunity, , Volume: 3, Issue:6, 2002

[A case of hepatitis C virus-associated glomerulonephropathy presenting with MPO-ANCA-positive rapidly progressive glomerulonephritis].
Nihon Jinzo Gakkai shi, , Volume: 42, Issue:4, 2000

Interferon/antioxidant combination therapy for chronic hepatitis C--a controlled pilot trial.
Antiviral research, , Volume: 43, Issue:2, 1999

Levels of malondialdehyde, myeloperoxidase and nitrotyrosine in patients with chronic viral hepatitis B and C.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, , Volume: 21, Issue:1

Double-Stranded DNA and NETs Components in Relation to Clinical Outcome After ST-Elevation Myocardial Infarction.
Scientific reports, , 03-19, Volume: 10, Issue:1, 2020

Microscopic polyangiitis: A little-known new risk factor of venous thrombosis.
Journal des maladies vasculaires, , Volume: 40, Issue:6, 2015

Myeloperoxidase and plaque vulnerability.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 24, Issue:7, 2004

Anti-glomerular Basement Membrane Disease Concomitant with MPO-ANCA Positivity Concurrent with High Serum Levels of Interleukin-26 Following Coronavirus Disease 2019 Vaccination.
Internal medicine (Tokyo, Japan), , Apr-01, Volume: 62, Issue:7, 2023

Clinical features and prognosis of MPO-ANCA and anti-GBM double-seropositive patients.
Frontiers in immunology, , Volume: 13, 2022

Inhibitory Anti-Peroxidasin Antibodies in Pulmonary-Renal Syndromes.
Journal of the American Society of Nephrology : JASN, , Volume: 29, Issue:11, 2018

Peroxidasin-a Novel Autoantigen in Anti-GBM Disease?
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Autoantibodies against Linear Epitopes of Myeloperoxidase in Anti-Glomerular Basement Membrane Disease.
Clinical journal of the American Society of Nephrology : CJASN, , Apr-07, Volume: 11, Issue:4, 2016

Anti-glomerular basement membrane (anti-GBM) disease accompanied by vasculitis that was not positive for antineutrophil cytoplasmic antibodies to myeloperoxidase and proteinase 3: a report of two cases and the incidence of anti-GBM disease at one institut
Clinical and experimental nephrology, , Volume: 15, Issue:4, 2011

Asymptomatic autoantibodies associate with future anti-glomerular basement membrane disease.
Journal of the American Society of Nephrology : JASN, , Volume: 22, Issue:10, 2011

Autoantibodies: what's in their teeth?
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[79-year-old patient with pulmorenal syndrome].
Deutsche medizinische Wochenschrift (1946), , Volume: 135, Issue:40, 2010

Anti-GBM antibodies co-exist with MPO-ANCA in a 4-year-old girl with acute renal failure.
Pediatric nephrology (Berlin, Germany), , Volume: 24, Issue:1, 2009

Clinical outcome of patients with coexistent antineutrophil cytoplasmic antibodies and antibodies against glomerular basement membrane.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, , Volume: 13, Issue:4, 2009

Autoimmunity in kidney diseases.
Scandinavian journal of clinical and laboratory investigation. Supplementum, , Volume: 241, 2008

The role ANCA and anti-GBM antibodies in pulmonary-renal syndrome due to Wegener's granulomatosis.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, , Volume: 58 Suppl 5, Issue:Pt 2, 2007

Role of antineutrophil cytoplasmic antibodies and glomerular basement membrane antibodies in the diagnosis and monitoring of systemic vasculitides.
Annals of clinical biochemistry, , Volume: 44, Issue:Pt 5, 2007

[Pulmonary-renal syndrome and Goodpasture's syndrome].
Nihon rinsho. Japanese journal of clinical medicine, , Volume: 62 Suppl 5, 2004

Use of immunofluorescence and confocal laser scanning microscopy in identifying rare cases of anti-neutrophil cytoplasmic antibodies (ANCA) showing dual specificities to myeloperoxidase and proteinase3.
Journal of fluorescence, , Volume: 14, Issue:4, 2004

Successful renal transplantation in a child with ANCA-associated microscopic polyangiitis.
Pediatric nephrology (Berlin, Germany), , Volume: 18, Issue:7, 2003

Simultaneous occurrence of diabetic glomerulosclerosis, IgA nephropathy, crescentic glomerulonephritis, and myeloperoxidase-antineutrophil cytoplasmic antibody seropositivity in a Chinese patient.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 40, Issue:4, 2002

[Lung involvement in rapidly progressive glomerulonephritis].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, , Volume: 39, Issue:2, 2001

Sequential development of pulmonary hemorrhage with MPO-ANCA complicating anti-glomerular basement membrane antibody-mediated glomerulonephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 35, Issue:5, 2000

Goodpasture's syndrome associated with primary biliary cirrhosis.
Internal medicine (Tokyo, Japan), , Volume: 37, Issue:7, 1998

[An experience of treatment of double positive myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCA) and anti-glomerular basement membrane antibodies in Goodpasture's syndrome onset of crescentic glomerulonephritis].
Nihon Jinzo Gakkai shi, , Volume: 40, Issue:8, 1998

Expression of iNOS, eNOS, and peroxynitrite-modified proteins in experimental anti-myeloperoxidase associated crescentic glomerulonephritis.
Kidney international, , Volume: 53, Issue:2, 1998

Myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis with membranous nephropathy in remission.
Internal medicine (Tokyo, Japan), , Volume: 36, Issue:11, 1997

[A case of Goodpasture's syndrome with myeloperoxidase specific anti-neutrophil cytoplasmic autoantibody (MPO-ANCA) during chronic interstitial pneumonia].
Nihon Kyobu Shikkan Gakkai zasshi, , Volume: 35, Issue:12, 1997

Rapid screening assay for anti-GBM antibody and ANCAs; an important tool for the differential diagnosis of pulmonary renal syndromes.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 12, Issue:9, 1997

Goodpasture-like syndrome associated with anti-myeloperoxidase antibodies following penicillamine treatment.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 10, Issue:10, 1995

Circulating autoantibodies as serological markers in the differential diagnosis of pulmonary renal syndrome.
Journal of internal medicine, , Volume: 238, Issue:2, 1995

Use of antineutrophil cytoplasmic autoantibodies in diagnosing vasculitis in a Chinese patient population.
American journal of nephrology, , Volume: 14, Issue:2, 1994

Characterization of a non-Goodpasture autoantibody to type IV collagen.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 8, Issue:11, 1993

Antineutrophil-cytoplasmic antibodies and antiglomerular basement membrane antibodies in Goodpasture's syndrome and in Wegener's granulomatosis.
Journal of the American Society of Nephrology : JASN, , Volume: 2, Issue:7, 1992

A case of Goodpasture's syndrome associated with anti-myeloperoxidase antibodies.
Internal medicine (Tokyo, Japan), , Volume: 31, Issue:2, 1992

Circulating autoantibodies in patients with extracapillary glomerulonephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 6, Issue:6, 1991

[A case of Goodpasture's syndrome. Myeloperoxidase antibodies as a valuable serological marker in vasculitis].
Lakartidningen, , Oct-17, Volume: 87, Issue:42, 1990

Prevalence of Anti-Neutrophil Cytoplasmic Antibodies and Associated Vasculitis in COPD Associated With Alpha-1 Antitrypsin Deficiency: An Ancillary Study to a Prospective Study on 180 French Patients.
Chest, , Volume: 158, Issue:5, 2020

Therapy with plasma purified alpha1-antitrypsin (Prolastin®) induces time-dependent changes in plasma levels of MMP-9 and MPO.
PloS one, , Volume: 10, Issue:1, 2015

Variability of sputum inflammatory mediators in COPD and α1-antitrypsin deficiency.
The European respiratory journal, , Volume: 40, Issue:3, 2012

The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo.
Thorax, , Volume: 66, Issue:8, 2011

Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency.
Respiratory medicine, , Volume: 100, Issue:6, 2006

Neutrophil functions of patients with MPO-ANCA-related vasculitis.
Internal medicine (Tokyo, Japan), , Volume: 42, Issue:7, 2003

The effect of augmentation therapy on bronchial inflammation in alpha1-antitrypsin deficiency.
American journal of respiratory and critical care medicine, , Jun-01, Volume: 165, Issue:11, 2002

Analysis of anti-neutrophil cytoplasmic antibodies (ANCA): frequency and specificity in a sample of 191 homozygous (PiZZ) alpha1-antitrypsin-deficient subjects.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 16, Issue:1, 2001

Bronchial inflammation: its relationship to colonizing microbial load and alpha(1)-antitrypsin deficiency.
Chest, , Volume: 117, Issue:5 Suppl 1, 2000

Evidence for excessive bronchial inflammation during an acute exacerbation of chronic obstructive pulmonary disease in patients with alpha(1)-antitrypsin deficiency (PiZ).
American journal of respiratory and critical care medicine, , Volume: 160, Issue:6, 1999

Alpha 1-antitrypsin deficiency and anti-proteinase 3 antibodies in anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis.
Clinical and experimental immunology, , Volume: 100, Issue:2, 1995

Adverse effects of neutrophils on the lung.
The American journal of medicine, , Jun-22, Volume: 92, Issue:6A, 1992

Assessment of a multi-assay biological diagnostic test for mood disorders in a Japanese population.
Neuroscience letters, , Jan-26, Volume: 612, 2016

The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future.
BMC psychiatry, , Aug-18, Volume: 4, 2004

Investigation of DNA damage, oxidative stress, and inflammation in synthetic cannabinoid users.
Human & experimental toxicology, , Volume: 39, Issue:11, 2020

Epistasis of oxidative stress-related enzyme genes on modulating the risks in oral cavity cancer.
Clinica chimica acta; international journal of clinical chemistry, , Nov-11, Volume: 411, Issue:21-22, 2010

Effects of Stealth adulterant on immunoassay testing for drugs of abuse.
Journal of analytical toxicology, , Volume: 25, Issue:6, 2001

Levamisole-contaminated cocaine: a hairy affair.
BMJ case reports, , Aug-26, Volume: 2015, 2015

Myeloperoxidase and C-reactive protein in patients with cocaine-associated chest pain.
The American journal of emergency medicine, , Volume: 31, Issue:4, 2013

Contaminated cocaine and antineutrophil cytoplasmic antibody-associated disease.
Clinical journal of the American Society of Nephrology : CJASN, , Volume: 6, Issue:12, 2011

Clinical and immunological features of drug-induced and infection-induced proteinase 3-antineutrophil cytoplasmic antibodies and myeloperoxidase-antineutrophil cytoplasmic antibodies and vasculitis.
Current opinion in rheumatology, , Volume: 22, Issue:1, 2010

Editorial comment on: Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use.
European urology, , Volume: 52, Issue:2, 2007

Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use.
European urology, , Volume: 52, Issue:2, 2007

Epstein-Barr virus reactivation induced myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis.
BMJ case reports, , Oct-07, Volume: 14, Issue:10, 2021

Clinical interpretation of antineutrophil cytoplasmic antibodies: parvovirus B19 infection as a pitfall.
Annals of the rheumatic diseases, , Volume: 64, Issue:4, 2005

[ERRORS IN DIAGNOSIS AND TREATMENT OF IMMUNODEPENDENT PATHOLOGY (ORIGINAL CONCEPT)].
Likars'ka sprava, , Issue:7-8

Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome.
Acta cirurgica brasileira, , Volume: 29, Issue:9, 2014

Clinical significance of a myeloperoxidase gene polymorphism and inducible nitric oxide synthase expression in cirrhotic patients with hepatopulmonary syndrome.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, , Volume: 30, Issue:4, 2010

Interleukin-10 inhibits pulmonary NF-kappaB activation and lung injury induced by hepatic ischemia-reperfusion.
The American journal of physiology, , Volume: 277, Issue:5, 1999

Myeloperoxidase activity is increased in hepatopulmonary syndrome in rats.
Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery, , Volume: 26, Issue:4

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease.
American journal of physiology. Gastrointestinal and liver physiology, , Oct-01, Volume: 323, Issue:4, 2022

[Determination and significance of serum MPO and amylin in adult patients with OSAHS after short-range noninvasive positive pressure ventilation].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, , Jun-05, Volume: 31, Issue:11, 2017

[Expression of intercellular adhesion molecule-1 and myeloperoxidase in peripheral blood and its significance in elderly patients with OSAHS].
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[Expression and significance of serum hepatocyte growth factor and myeloperoxidase in patients with obstructive sleep apnea hypopnea syndrome].
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The Relationship Among Oxidative and Anti-Oxidative Parameters and Myeloperoxidase in Subjects With Obstructive Sleep Apnea Syndrome.
Respiratory care, , Volume: 61, Issue:2, 2016

Effect of Continuous Positive Airway Pressure on Cardiovascular Biomarkers: The Sleep Apnea Stress Randomized Controlled Trial.
Chest, , Volume: 150, Issue:1, 2016

Do salivary and serum collagenases have a role in an association between obstructive sleep apnea syndrome and periodontal disease? A preliminary case-control study.
Archives of oral biology, , Volume: 60, Issue:1, 2015

Increased plasma soluble tumor necrosis factor receptor-1 and myeloperoxidase activity in patients with obstructive sleep apnea syndrome.
The International journal of neuroscience, , Volume: 125, Issue:9, 2015

Salivary and serum myeloperoxidase in obstructive sleep apnea.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, , Jun-01, Volume: 41, Issue:3, 2012

An experimental research on chronic intermittent hypoxia leading to liver injury.
Sleep & breathing = Schlaf & Atmung, , Volume: 15, Issue:3, 2011

Oxidative stress markers in pregnant women who snore and fetal outcome: a case control study.
Acta obstetricia et gynecologica Scandinavica, , Volume: 86, Issue:11, 2007

MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma.
International journal of molecular sciences, , Jan-28, Volume: 21, Issue:3, 2020

Association of Pulmonary Hemorrhage, Positive Proteinase 3, and Urinary Red Blood Cell Casts With Venous Thromboembolism in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Arthritis & rheumatology (Hoboken, N.J.), , Volume: 71, Issue:11, 2019

Histological criteria for age determination of fatal venous thromboembolism.
International journal of legal medicine, , Volume: 132, Issue:3, 2018

[Case of cerebral venous thrombosis caused by MPO-ANCA associated hypertrophic pachymeningitis].
Rinsho shinkeigaku = Clinical neurology, , Volume: 54, Issue:10, 2014

Systemically circulating oxidative species in human deep venous thrombosis.
European journal of emergency medicine : official journal of the European Society for Emergency Medicine, , Volume: 5, Issue:1, 1998

Anti-neutrophil cytoplasmic antibodies in 566 European patients with systemic lupus erythematosus: prevalence, clinical associations and correlation with other autoantibodies. European Concerted Action on the Immunogenetics of SLE.
Clinical and experimental rheumatology, , Volume: 16, Issue:5

[A study of free radical defense and oxidative stress in the sera of patients with neuroimmunological disorders].
Arerugi = [Allergy], , Volume: 49, Issue:1, 2000

Umbilical cord serum interleukin-6, C-reactive protein, and myeloperoxidase concentrations at birth and association with neonatal morbidities and long-term neurodevelopmental outcomes.
American journal of perinatology, , Volume: 31, Issue:8, 2014

Multiple atherosclerosis-related biomarkers associated with short- and long-term mortality after stroke.
Clinical biochemistry, , Volume: 45, Issue:16-17, 2012

The predictive value of serum myeloperoxidase for vasospasm in patients with aneurysmal subarachnoid hemorrhage.
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Alpha lipoic acid alleviates oxidative stress and preserves blood brain permeability in rats with subarachnoid hemorrhage.
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No apparent role for neutrophils and neutrophil-derived myeloperoxidase in experimental subarachnoid haemorrhage and vasospasm: a preliminary study.
Acta neurochirurgica, , Volume: 142, Issue:1, 2000

Dose-dependent effects of adalimumab in neonatal rats with hypoxia/reoxygenation-induced intestinal damage.
Bosnian journal of basic medical sciences, , Feb-01, Volume: 21, Issue:1, 2021

Inhibition of A
Mediators of inflammation, , Volume: 2020, 2020

Ginger (Zingiber officinale Roscoe) for the treatment and prevention of necrotizing enterocolitis.
Journal of ethnopharmacology, , Oct-28, Volume: 225, 2018

The effect of vascular endothelial growth factor overexpression in experimental necrotizing enterocolitis.
Pediatric surgery international, , Volume: 30, Issue:3, 2014

Umbilical cord serum interleukin-6, C-reactive protein, and myeloperoxidase concentrations at birth and association with neonatal morbidities and long-term neurodevelopmental outcomes.
American journal of perinatology, , Volume: 31, Issue:8, 2014

Beneficial effects of Nigella sativa oil on intestinal damage in necrotizing enterocolitis.
Journal of investigative surgery : the official journal of the Academy of Surgical Research, , Volume: 25, Issue:5, 2012

Protective effects of caffeic acid phenethyl ester (CAPE) on intestinal damage in necrotizing enterocolitis.
Pediatric surgery international, , Volume: 27, Issue:11, 2011

Protective effect of tumor necrosis factor alpha antibody on experimental necrotizing enterocolitis in the rat.
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Sida tuberculata reduces oxidative stress and pain caused by the knee osteoarthritis.
Journal of ethnopharmacology, , Feb-10, Volume: 248, 2020

Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial.
BMC complementary and alternative medicine, , May-17, Volume: 14, 2014

One-year follow-up of Coll2-1, Coll2-1NO2 and myeloperoxydase serum levels in osteoarthritis patients after hip or knee replacement.
Annals of the rheumatic diseases, , Volume: 67, Issue:2, 2008

Myeloperoxidase and chlorinated peptides in osteoarthritis: potential biomarkers of the disease.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, , Volume: 25, Issue:9, 2007

Effect of Mud-Bath Therapy on Serum Biomarkers in Patients with Knee Osteoarthritis: Results from a Randomized Controlled Trial.
The Israel Medical Association journal : IMAJ, , Volume: 18, Issue:3-4

Hypochlorous acid exposure impairs skeletal muscle function and Ca
The Journal of physiology, , Volume: 601, Issue:23, 2023

Oxidative damage to urinary proteins from the GRMD dog and mdx mouse as biomarkers of dystropathology in Duchenne muscular dystrophy.
PloS one, , Volume: 15, Issue:10, 2020

Levels of inflammation and oxidative stress, and a role for taurine in dystropathology of the Golden Retriever Muscular Dystrophy dog model for Duchenne Muscular Dystrophy.
Redox biology, , Volume: 9, 2016

Immunohistochemical staining of dystrophin on formalin-fixed paraffin-embedded sections in Duchenne/Becker muscular dystrophy and manifesting carriers of Duchenne muscular dystrophy.
Neuromuscular disorders : NMD, , Volume: 10, Issue:6, 2000

Association Between IL-5 Levels and the Clinicopathologic Features of Eosinophilic Granulomatosis With Polyangiitis.
Neurology, , 02-02, Volume: 96, Issue:5, 2021

Polyangiitis overlap syndrome: a novel presentation of microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis.
BMJ case reports, , Feb-01, Volume: 14, Issue:2, 2021

Eosinophilic granulomatosis with polyangiitis presenting with myositis: case based review.
Rheumatology international, , Volume: 40, Issue:7, 2020

A case of MPO-ANCA-positive polyarteritis nodosa complicated by exudative otitis media, mononeuritis multiplex, and acute renal failure.
Clinical and experimental nephrology, , Volume: 15, Issue:5, 2011

Medial medullary infarction caused by antineutrophil cytoplasmic antibody-related vasculitis: Case report and review of the literature.
Medicine, , Volume: 96, Issue:33, 2017

Dysfunctional HDL in acute stroke.
Atherosclerosis, , Volume: 253, 2016

Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke.
Journal of neuroinflammation, , 05-24, Volume: 13, Issue:1, 2016

Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia.
Experimental neurology, , Volume: 264, 2015

Impact of the neutrophil response to granulocyte colony-stimulating factor on the risk of hemorrhage when used in combination with tissue plasminogen activator during the acute phase of experimental stroke.
Journal of neuroinflammation, , May-27, Volume: 11, 2014

The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke.
Neuropharmacology, , Volume: 81, 2014

Neuroprotective effect of naringenin is mediated through suppression of NF-κB signaling pathway in experimental stroke.
Neuroscience, , Jan-29, Volume: 230, 2013

Immune following suppression mesenchymal stem cell transplantation in the ischemic brain is mediated by TGF-β.
Neurobiology of disease, , Volume: 58, 2013

Gradient echo T2*-weighted magnetic resonance imaging revealing cerebral microbleeds in a patient with microscopic polyangiitis complicated by cerebrovascular disease.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 21, Issue:8, 2012

Tropisetron ameliorates ischemic brain injury in an embolic model of stroke.
Brain research, , May-25, Volume: 1392, 2011

The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury.
Journal of neurochemistry, , Volume: 113, Issue:4, 2010

Spatio-temporal distribution of inflammatory reaction and expression of TLR2/4 signaling pathway in rat brain following permanent focal cerebral ischemia.
Neurochemical research, , Volume: 35, Issue:8, 2010

Neuroprotective efficacy and therapeutic window of Forsythoside B: in a rat model of cerebral ischemia and reperfusion injury.
European journal of pharmacology, , Aug-25, Volume: 640, Issue:1-3, 2010

[Case of multiple brain infarction with MPO-ANCA].
Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 60, Issue:9, 2008

Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation.
Journal of neurochemistry, , Volume: 104, Issue:2, 2008

Synthetic fibronectin peptide exerts neuroprotective effects on transient focal brain ischemia in rats.
Brain research, , Aug-23, Volume: 1054, Issue:1, 2005

17beta-estradiol potentiates ischemia-reperfusion injury in diabetic ovariectomized female rats.
Brain research, , Aug-30, Volume: 1054, Issue:2, 2005

Myeloperoxidase polymorphisms in brain infarction. Association with infarct size and functional outcome.
Atherosclerosis, , Volume: 167, Issue:2, 2003

Neuroprotective effects of (S)-N-[4-[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)carbonyl]-1-piperazinyl]phenyl]-2-thiophenecarboximid-amide (BN 80933), an inhibitor of neuronal nitric-oxide synthase and an antioxidant, in model of
The Journal of pharmacology and experimental therapeutics, , Volume: 306, Issue:2, 2003

3-Aminobenzamide reduces brain infarction and neutrophil infiltration after transient focal cerebral ischemia in mice.
Experimental neurology, , Volume: 184, Issue:2, 2003

Deficiency of myeloperoxidase increases infarct volume and nitrotyrosine formation in mouse brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 22, Issue:1, 2002

Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody: a bedside-to-bench study.
Stroke, , Volume: 32, Issue:11, 2001

Progesterone inhibits inflammatory response pathways after permanent middle cerebral artery occlusion in rats.
Molecular medicine reports, , Volume: 4, Issue:2

Association between myeloperoxidase and the risks of ischemic stroke, heart failure, and atrial fibrillation: A Mendelian randomization study.
Nutrition, metabolism, and cardiovascular diseases : NMCD, , Volume: 33, Issue:1, 2023

The value of serum Lp-PLA2 combined with MPO in the diagnosis of cerebral infarction caused by large artery atherosclerosis.
Clinical neurology and neurosurgery, , Volume: 232, 2023

Myeloperoxidase is Independently Associated with Incident Heart Failure in Patients with Coronary Artery Disease and Kidney Disease.
Current problems in cardiology, , Volume: 47, Issue:11, 2022

Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia.
Frontiers in immunology, , Volume: 13, 2022

Exploratory Investigation of Intestinal Structure and Function after Stroke in Mice.
Mediators of inflammation, , Volume: 2021, 2021

Neutrophil extracellular traps (NETs) infiltrate haematoma and surrounding brain tissue after intracerebral haemorrhage: A post-mortem study.
Neuropathology and applied neurobiology, , Volume: 47, Issue:6, 2021

DNA Hypomethylation of the MPO Gene in Peripheral Blood Leukocytes Is Associated with Cerebral Stroke in the Acute Phase.
Journal of molecular neuroscience : MN, , Volume: 71, Issue:9, 2021

Analysis of the association of MPO and MMP-9 with stroke severity and outcome: Cohort study.
Neurology, , 07-07, Volume: 95, Issue:1, 2020

Plasma myeloperoxidase levels in acute brain ischaemia and high grade carotid stenosis.
European journal of neurology, , Volume: 27, Issue:8, 2020

Impaired antioxidative activity of high-density lipoprotein is associated with more severe acute ischemic stroke.
Metabolism: clinical and experimental, , Volume: 98, 2019

Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke.
Life sciences, , Jan-01, Volume: 216, 2019

Recognizing Central Nervous System Involvement as a Progressive Feature of Microscopic Polyangiitis: A Diagnostic Dilemma.
The American journal of medicine, , Volume: 132, Issue:9, 2019

Serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase and myeloperoxidase in ischemic stroke.
Atherosclerosis, , Volume: 271, 2018

Inhibition of Myeloperoxidase by
The Journal of pharmacology and experimental therapeutics, , Volume: 364, Issue:2, 2018

Genetic Variations of Oxidative Stress Related Genes ALOX5, ALOX5AP and MPO Modulate Ischemic Stroke Susceptibility Through Main Effects and Epistatic Interactions in a Chinese Population.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , Volume: 43, Issue:4, 2017

Ischaemic stroke and the recanalization drug tissue plasminogen activator interfere with antibacterial phagocyte function.
Journal of neuroinflammation, , 07-21, Volume: 14, Issue:1, 2017

Nanoliposome containing cyclosporine A reduced neuroinflammation responses and improved neurological activities in cerebral ischemia/reperfusion in rat.
Fundamental & clinical pharmacology, , Volume: 31, Issue:2, 2017

Association of Osteopontin, Neopterin, and Myeloperoxidase With Stroke Risk in Patients With Prior Stroke or Transient Ischemic Attacks: Results of an Analysis of 13 Biomarkers From the Stroke Prevention by Aggressive Reduction in Cholesterol Levels Trial
Stroke, , Volume: 48, Issue:12, 2017

Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke.
Brain : a journal of neurology, , Oct-01, Volume: 140, Issue:10, 2017

Platelets and Inflammatory Parameters Do Not Affect Long-Term Survival after Acute Stroke.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 25, Issue:8, 2016

Beyond Cholesterol - New Cardiovascular Biomarkers.
Nestle Nutrition Institute workshop series, , Volume: 84, 2016

Inflammatory Biomarkers in Childhood Arterial Ischemic Stroke: Correlates of Stroke Cause and Recurrence.
Stroke, , Volume: 47, Issue:9, 2016

Myeloperoxidase Inhibition Increases Neurogenesis after Ischemic Stroke.
The Journal of pharmacology and experimental therapeutics, , Volume: 359, Issue:2, 2016

Neuroinflammatory response to experimental stroke is inhibited by eriodictyol.
Behavioural brain research, , 10-01, Volume: 312, 2016

Dysfunctional HDL in acute stroke.
Atherosclerosis, , Volume: 253, 2016

The economic impact of implementing a multiple inflammatory biomarker-based approach to identify, treat, and reduce cardiovascular risk.
Journal of medical economics, , Volume: 18, Issue:7, 2015

Serum myeloperoxidase levels in predicting the severity of stroke and mortality in acute ischemic stroke patients.
European review for medical and pharmacological sciences, , Volume: 19, Issue:11, 2015

Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 35, Issue:3, 2015

The Effect of Pre-Condition Cerebella Fastigial Nucleus Electrical Stimulation within and beyond the Time Window of Thrombolytic on Ischemic Stroke in the Rats.
PloS one, , Volume: 10, Issue:5, 2015

Novel inflammatory biomarkers and their correlation to Chlamydia pneumoniae titres in acute ischemic stroke.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 23, Issue:9, 2014

Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study.
Innate immunity, , Volume: 20, Issue:5, 2014

[Case of CNS-limited ANCA-associated vasculitis presenting as recurrent ischemic stroke].
Rinsho shinkeigaku = Clinical neurology, , Volume: 54, Issue:5, 2014

The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke.
Neuropharmacology, , Volume: 81, 2014

High-density lipoproteins limit neutrophil-induced damage to the blood-brain barrier in vitro.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 33, Issue:4, 2013

Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice.
Clinics (Sao Paulo, Brazil), , Volume: 68, Issue:3, 2013

Serum levels of anti-apolipoprotein A-1 auto-antibodies and myeloperoxidase as predictors of major adverse cardiovascular events after carotid endarterectomy.
Thrombosis and haemostasis, , Volume: 109, Issue:4, 2013

Usefulness of cardiac biomarker score for risk stratification in stable patients undergoing elective cardiac evaluation across glycemic status.
The American journal of cardiology, , Feb-15, Volume: 111, Issue:4, 2013

Plasma myeloperoxidase predicts incident cardiovascular risks in stable patients undergoing medical management for coronary artery disease.
Clinical chemistry, , Volume: 57, Issue:1, 2011

Tropisetron ameliorates ischemic brain injury in an embolic model of stroke.
Brain research, , May-25, Volume: 1392, 2011

Variants in the inflammatory IL6 and MPO genes modulate stroke susceptibility through main effects and gene-gene interactions.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 31, Issue:8, 2011

Plasma myeloperoxidase levels in patients with acute ischemic stroke.
Romanian journal of internal medicine = Revue roumaine de medecine interne, , Volume: 48, Issue:1, 2010

Oxidative stress after thrombolysis-induced reperfusion in human stroke.
Stroke, , Volume: 41, Issue:4, 2010

Immunomodulatory effect of Hawthorn extract in an experimental stroke model.
Journal of neuroinflammation, , Dec-30, Volume: 7, 2010

Colonic bacterial translocation as a possible factor in stress-worsening experimental stroke outcome.
American journal of physiology. Regulatory, integrative and comparative physiology, , Volume: 296, Issue:4, 2009

Myeloperoxidase, but not C-reactive protein, predicts cardiovascular risk in peripheral arterial disease.
European heart journal, , Volume: 29, Issue:2, 2008

Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase.
Proceedings of the National Academy of Sciences of the United States of America, , Nov-25, Volume: 105, Issue:47, 2008

Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke.
Stroke, , Volume: 39, Issue:4, 2008

Hypothermia in acute stroke--slow versus fast rewarming an experimental study in rats.
Experimental neurology, , Volume: 204, Issue:1, 2007

Characterization of a rat model to study acute neuroinflammation on histopathological, biochemical and functional outcomes.
Journal of neuroscience methods, , Jun-15, Volume: 144, Issue:2, 2005

Matrix metalloproteinase-9 and myeloperoxidase expression: quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemia.
Stroke, , Volume: 35, Issue:5, 2004

Myeloperoxidase polymorphisms in brain infarction. Association with infarct size and functional outcome.
Atherosclerosis, , Volume: 167, Issue:2, 2003

Effects of a selective CD11b/CD18 antagonist and recombinant human tissue plasminogen activator treatment alone and in combination in a rat embolic model of stroke.
Stroke, , Volume: 34, Issue:7, 2003

Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody: a bedside-to-bench study.
Stroke, , Volume: 32, Issue:11, 2001

[Characteristics of some links of the antioxidant system in patients with complicated cerebral stroke].
Likars'ka sprava, , Issue:1

Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats.
Molecular medicine (Cambridge, Mass.), , Volume: 17, Issue:9-10

[Application of flow cytometry in the differential diagnosis of lymphoma/leukemia with aberrant antigen expression].
Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 33, Issue:6, 2004

Catalyzed signal amplification for cyclin D1 detection in mantle cell lymphoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, , Volume: 16, Issue:2, 2003

Inhibition of myeloperoxidase by N-acetyl lysyltyrosylcysteine amide reduces experimental autoimmune encephalomyelitis-induced injury and promotes oligodendrocyte regeneration and neurogenesis in a murine model of progressive multiple sclerosis.
Neuroreport, , 02-07, Volume: 29, Issue:3, 2018

Post treatment with Gastrodin suppresses oxidative stress and attenuates motor disorders following 6-OHDA induced Parkinson disease.
Neuroscience letters, , 11-01, Volume: 790, 2022

Modulation of key enzymes linked to Parkinsonism and neurologic disorders by Antiaris africana in rotenone-toxified rats.
Journal of basic and clinical physiology and pharmacology, , Dec-04, Volume: 31, Issue:3, 2019

Gastrodin microinjection suppresses 6-OHDA-induced motor impairments in parkinsonian rats: insights into oxidative balance and microglial activation in SNc.
Inflammopharmacology, , Volume: 26, Issue:5, 2018

[Myeloperoxidase in the neurodegenerative process of Parkinson's disease].
Deutsche medizinische Wochenschrift (1946), , Volume: 139, Issue:3, 2014

Pre-treatment with silymarin reduces brain myeloperoxidase activity and inflammatory cytokines in 6-OHDA hemi-parkinsonian rats.
Neuroscience letters, , Oct-25, Volume: 555, 2013

Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-13, Volume: 25, Issue:28, 2005

Hypertrophic pachymeningitis with anti-neutrophil cytoplasmic antibody (p-ANCA), and diabetes insipidus.
Acta neurologica Scandinavica, , Volume: 104, Issue:6, 2001

Neuroinflammation and histone H3 citrullination are increased in X-linked Dystonia Parkinsonism post-mortem prefrontal cortex.
Neurobiology of disease, , Volume: 144, 2020

[Hypovolemia and oxidative stress in patients with burn injuries].
Orvosi hetilap, , Apr-05, Volume: 150, Issue:14, 2009

Neuroinflammation after neonatal hypoxia-ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult.
Molecular and cellular biochemistry, , Volume: 403, Issue:1-2, 2015

Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways.
Apoptosis : an international journal on programmed cell death, , Volume: 17, Issue:5, 2012

Hypoxic-ischemic brain injury stimulates inflammatory response and enzymatic activities in the hippocampus of neonatal rats.
Brain research, , May-04, Volume: 1388, 2011

The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury.
Journal of neurochemistry, , Volume: 113, Issue:4, 2010

Low endogenous G-protein-coupled receptor kinase 2 sensitizes the immature brain to hypoxia-ischemia-induced gray and white matter damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-26, Volume: 28, Issue:13, 2008

Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats.
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Oxygen-glucose deprivation decreases glutathione levels and glutamate uptake in rat hippocampal slices.
Brain research, , Apr-14, Volume: 1083, Issue:1, 2006

Neuroprotective effect of urinary trypsin inhibitor against focal cerebral ischemia-reperfusion injury in rats.
Anesthesiology, , Volume: 98, Issue:2, 2003

Concurrent formation of peroxynitrite with the expression of inducible nitric oxide synthase in the brain during middle cerebral artery occlusion and reperfusion in rats.
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Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype.
International journal of molecular sciences, , Aug-22, Volume: 21, Issue:17, 2020

Allergenic properties of roasted peanut allergens may be reduced by peroxidase.
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Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer.
Nature, , Volume: 615, Issue:7950, 2023

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma.
International journal of molecular sciences, , Jan-28, Volume: 21, Issue:3, 2020

Endoscopic ultrasound-guided fine needle aspiration features of a pancreatic neoplasm with predominantly intraductal growth and prominent tubular cytomorphology: intraductal tubular carcinoma of the pancreas?
Diagnostic cytopathology, , Volume: 36, Issue:11, 2008

Associations of myeloperoxidase, interleukin-17A and heparin-binding EGF-like growth factor levels with in-stent restenosis after percutaneous coronary intervention: a single-centre case-control study in China.
BMJ open, , 11-06, Volume: 10, Issue:11, 2020

Increased levels of MMP-3, MMP-9 and MPO represent predictors of in-stent restenosis, while increased levels of ADMA, LCAT, ApoE and ApoD predict bare metal stent patency.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, , Volume: 159, Issue:4, 2015

Low basal levels of circulating adiponectin in patients undergoing coronary stenting predict in-stent restenosis, independently of basal levels of inflammatory markers: lipoprotein associated phospholipase A2, and myeloperoxidase.
Clinical biochemistry, , Volume: 41, Issue:18, 2008

Local Matrix Metalloproteinase 9 Level Determines Early Clinical Presentation of ST-Segment-Elevation Myocardial Infarction.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 36, Issue:12, 2016

System study of MPO promoter high-frequency polymorphic variants on transcription factor network.
Gene, , Apr-15, Volume: 560, Issue:2, 2015

Inflammatory status in patients with coronary artery disease.
European review for medical and pharmacological sciences, , Volume: 18, Issue:6, 2014

Comparision of inflammatory biomarkers for detection of coronary stenosis in patients with stable coronary artery disease.
European review for medical and pharmacological sciences, , Volume: 17, Issue:1, 2013

Association of biomarkers of lipid modification with functional and morphological indices of coronary stenosis severity in stable coronary artery disease.
Journal of cardiovascular translational research, , Volume: 6, Issue:4, 2013

Plasma myeloperoxidase predicts incident cardiovascular risks in stable patients undergoing medical management for coronary artery disease.
Clinical chemistry, , Volume: 57, Issue:1, 2011

Plasma myeloperoxidase concentration predicts the presence and severity of coronary disease in patients with chest pain and negative troponin-T.
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Determining decision limits for new biomarkers: clinical and statistical considerations.
Clinical chemistry, , Volume: 57, Issue:1, 2011

Concomitant coronary and peripheral arterial disease: relationship between the inflammatory status of the affected limb and the severity of coronary artery disease.
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Plasma myeloperoxidase is related to the severity of coronary artery disease.
Acta cardiologica, , Volume: 63, Issue:2, 2008

Effects of unfractionated heparin and glycoprotein IIb/IIIa antagonists versus bivalirdin on myeloperoxidase release from neutrophils.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 27, Issue:8, 2007

Controlled intermittent asystole cardiac therapy induced by pharmacologically potentiated vagus nerve stimulation in normal and hibernating myocardium.
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Nε-(carboxymethyl)lysine in debris from carotid artery stenting: multiple versus nonmultiple postoperative lesions.
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A ZBTB16-RARα Variant of Acute Promyelocytic Leukemia with Concurrent Myeloid Sarcoma Presenting as Sudden Onset Paraplegia.
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Myeloid Sarcoma of the Testis in Children: Clinicopathologic and Immunohistochemical Characteristics With KMT2A (MLL) Gene Rearrangement Correlation.
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Diagnostic challenges with intraoral myeloid sarcoma: report of two cases & review of world literature.
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[Granulocytic sarcoma: a clinical and pathologic analysis of ten cases].
Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 41, Issue:5, 2012

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Granulocytic sarcoma of the pancreas: a case report and review of the literatures.
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[Granulocytic sarcoma of uterine cervix: report of a case].
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[Clinicopathologic features of granulocytic sarcoma: a study of 38 cases].
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[A rare tumor of the main biliary duct].
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Gemtuzumab ozogamicin therapy for isolated extramedullary AML relapse after allogeneic hematopoietic stem-cell transplantation.
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Chloromas.
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Granulocytic sarcoma of the lips: report of an unusual case.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, , Volume: 105, Issue:1, 2008

[Meningeal granulocytic sarcoma: report of a case].
Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 36, Issue:11, 2007

Granulocytic sarcoma of breast: an aleukemic presentation.
Indian journal of medical sciences, , Volume: 61, Issue:3, 2007

Disseminated extramedullary myeloid tumor of the gallbladder without involvement of the bone marrow.
American journal of hematology, , Volume: 82, Issue:1, 2007

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Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 35, Issue:10, 2006

Myeloid sarcoma involving the gynecologic tract: a report of 11 cases and review of the literature.
American journal of clinical pathology, , Volume: 125, Issue:5, 2006

Nonleukemic granulocytic sarcoma in the bile duct: a case report.
Journal of Korean medical science, , Volume: 21, Issue:4, 2006

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Pathologica, , Volume: 97, Issue:5, 2005

Granulocytic sarcoma of the spine in a child without bone marrow involvement: a case report and literature review.
European journal of pediatrics, , Volume: 164, Issue:10, 2005

Granulocytic sarcoma manifesting as multiple skeletal lesions.
The American journal of the medical sciences, , Volume: 330, Issue:3, 2005

Sino-orbital chloroma presenting as unilateral proptosis in a boy.
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[Granulocytic sarcoma of the female vulvae].
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MYELOPEROXIDASE AND ASSOCIATED PORPHYRINS IN RAT CHLOROMA TISSUE. I.
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Therapeutic Lifestyle Changes Improve HDL Function by Inhibiting Myeloperoxidase-Mediated Oxidation in Patients With Metabolic Syndrome.
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Allopurinol improves endothelial function and reduces oxidant-inflammatory enzyme of myeloperoxidase in metabolic syndrome.
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Clinical laboratory, , Volume: 51, Issue:3-4, 2005

Clinical and subclinical intestinal inflammation assessed by the mucosal patch technique: studies of mucosal neutrophil and eosinophil activation in inflammatory bowel diseases and irritable bowel syndrome.
Gut, , Volume: 53, Issue:12, 2004

Visceral hypersensitivity and altered colonic motility after subsidence of inflammation in a rat model of colitis.
World journal of gastroenterology, , Volume: 9, Issue:12, 2003

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Association between nutritional, inflammatory and oxidative status (NIOS) and risk of adverse outcomes in patients on haemodialysis (HD): the NIOS-HD prospective cohort study protocol.
BMJ open, , 09-20, Volume: 12, Issue:9, 2022

A methodologic framework for modeling and assessing biomarkers of environmental enteropathy as predictors of growth in infants: an example from a Peruvian birth cohort.
The American journal of clinical nutrition, , Volume: 106, Issue:1, 2017

Causal Pathways from Enteropathogens to Environmental Enteropathy: Findings from the MAL-ED Birth Cohort Study.
EBioMedicine, , Volume: 18, 2017

Protein- and zinc-deficient diets modulate the murine microbiome and metabolic phenotype.
The American journal of clinical nutrition, , Volume: 104, Issue:5, 2016

Preoperative vitamin C supplementation improves colorectal anastomotic healing and biochemical parameters in malnourished rats.
International journal of colorectal disease, , Volume: 31, Issue:11, 2016

Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants.
The American journal of tropical medicine and hygiene, , Volume: 88, Issue:2, 2013

Serum myeloperoxidase and mortality in maintenance hemodialysis patients.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 48, Issue:1, 2006

Noma-like gangrenous cheilitis in a child with cyclic neutropenia associated with myeloperoxidase deficiency.
Pediatric dermatology, , Volume: 20, Issue:6

Myeloperoxidase as a biomarker for intestinal-brain axis dysfunction induced by malnutrition and Cryptosporidium infection in weanling mice.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, , Volume: 27, Issue:3

ANCA-associated vasculitis in scleroderma: A renal perspective .
Clinical nephrology, , Volume: 90, Issue:6, 2018

Salivary: flow and proteins of the innate and adaptive immunity in the limited and diffused systemic sclerosis.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, , Volume: 43, Issue:7, 2014

A patient with diffuse cutaneous systemic sclerosis complicated by antineutrophil-cytoplasmic antibody-associated vasculitis exhibiting honeycomb lung without volume loss.
Internal medicine (Tokyo, Japan), , Volume: 53, Issue:7, 2014

Myeloperoxidase-antineutrophil cytoplasmic antibody seroconversion and fulminant vasculitis in Scl-70-positive scleroderma.
Internal medicine journal, , Volume: 37, Issue:3, 2007

ANCA-related crescentic glomerulonephritis in systemic sclerosis: revisiting the "normotensive scleroderma renal crisis".
Clinical nephrology, , Volume: 68, Issue:3, 2007

Salivary: flow and proteins of the innate and adaptive immunity in the limited and diffused systemic sclerosis.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, , Volume: 43, Issue:7, 2014

Steroid Receptor Coactivator-3 Is Required for Inhibition of the Intestinal Muscularis Inflammatory Response of Postoperative Ileus in Mice.
Inflammation, , Volume: 44, Issue:3, 2021

Inhibition of JAK1 mitigates postoperative ileus in mice.
Surgery, , Volume: 166, Issue:6, 2019

Anti-inflammatory effect of ginsenoside Rb1 contributes to the recovery of gastrointestinal motility in the rat model of postoperative ileus.
Biological & pharmaceutical bulletin, , Volume: 37, Issue:11, 2014

The novel orally active guanylhydrazone CPSI-2364 prevents postoperative ileus in mice independently of anti-inflammatory vagus nerve signaling.
Langenbeck's archives of surgery, , Volume: 397, Issue:7, 2012

Impact of CCR7 on the gastrointestinal field effect.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 300, Issue:4, 2011

GLP-2 receptor agonism ameliorates inflammation and gastrointestinal stasis in murine postoperative ileus.
The Journal of pharmacology and experimental therapeutics, , Volume: 333, Issue:2, 2010

A murine model for the study of edema induced intestinal contractile dysfunction.
Neurogastroenterology and motility, , Volume: 22, Issue:10, 2010

A single intraperitoneal dose of carbon monoxide-saturated ringer's lactate solution ameliorates postoperative ileus in mice.
The Journal of pharmacology and experimental therapeutics, , Volume: 319, Issue:3, 2006

The ICAM-1 antisense oligonucleotide ISIS-3082 prevents the development of postoperative ileus in mice.
British journal of pharmacology, , Volume: 146, Issue:2, 2005

Inhibition of intestinal transit by resuscitation-induced gut edema is reversed by L-NIL.
The Journal of surgical research, , Volume: 129, Issue:1, 2005

Tyrphostin AG 126 inhibits development of postoperative ileus induced by surgical manipulation of murine colon.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 286, Issue:2, 2004

Mechanisms of polymicrobial sepsis-induced ileus.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 287, Issue:3, 2004

Myeloperoxidase in Hypertensive Disorders of Pregnancy and Its Relation With Nitric Oxide.
Hypertension (Dallas, Tex. : 1979), , Volume: 69, Issue:6, 2017

Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats.
Naunyn-Schmiedeberg's archives of pharmacology, , Volume: 389, Issue:12, 2016

Fecal eosinophil cationic protein as a marker of active disease and treatment outcome in collagenous colitis: a pilot study.
Scandinavian journal of gastroenterology, , Volume: 46, Issue:7-8, 2011

Steroids reduce local inflammatory mediator secretion and mucosal permeability in collagenous colitis patients.
World journal of gastroenterology, , Nov-21, Volume: 12, Issue:43, 2006

Detection of inflammatory markers in stools from patients with irritable bowel syndrome and collagenous colitis.
Scandinavian journal of gastroenterology, , Volume: 41, Issue:1, 2006

Repeated exposure to intra-amniotic LPS partially protects against adverse effects of intravenous LPS in preterm lambs.
Innate immunity, , Volume: 20, Issue:2, 2014

Umbilical cord serum interleukin-6, C-reactive protein, and myeloperoxidase concentrations at birth and association with neonatal morbidities and long-term neurodevelopmental outcomes.
American journal of perinatology, , Volume: 31, Issue:8, 2014

Amniotic fluid myeloperoxidase in pregnancies complicated by preterm prelabor rupture of membranes.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, , Volume: 26, Issue:5, 2013

Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs.
American journal of physiology. Lung cellular and molecular physiology, , Feb-15, Volume: 302, Issue:4, 2012

Cerebellopathy secondary to anti-peroxidase antibody-mediated toxicity. A special case of Hashimoto encephalopathy.
Journal of neuroimmunology, , 11-15, Volume: 312, 2017

Thyroid autoimmunity: is really associated with papillary thyroid carcinoma?
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, , Volume: 274, Issue:3, 2017

Serum negative autoimmune thyroiditis displays a milder clinical picture compared with classic Hashimoto's thyroiditis.
European journal of endocrinology, , Volume: 171, Issue:1, 2014

[Distribution of IgG subclasses of TgAb and TPOAb in sera from patients with Graves' disease, Graves' disease plus Hashimoto's thyroiditis and Hashimoto's thyrotoxicosis].
Zhonghua yi xue za zhi, , Jan-14, Volume: 94, Issue:2, 2014

Hashimoto's thyroiditis as a risk factor of papillary thyroid cancer may improve cancer prognosis.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, , Volume: 148, Issue:3, 2013

Opsoclonus as a manifestation of Hashimoto's encephalopathy.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 19, Issue:10, 2012

[A case of MPO-ANCA-related microscopic polyangiitis with mixed cryoglobulinemia].
Nihon Jinzo Gakkai shi, , Volume: 48, Issue:4, 2006

Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides.
Arthritis research & therapy, , Volume: 7, Issue:5, 2005

Cryoglobulins and multispecific antineutrophil cytoplasmic antibodies in propylthiouracil-induced necrotizing cutaneous vasculitis--a new association.
European journal of dermatology : EJD, , Volume: 22, Issue:5

Plasma Concentrations of New Biochemical Markers of Atherosclerosis in Patients with Dyslipidemia-A Pilot Study.
Medicina (Kaunas, Lithuania), , May-27, Volume: 58, Issue:6, 2022

Long-term follow-up of circulating oxidative stress markers in patients undergoing lipoprotein apheresis by Direct Adsorption of Lipids (DALI).
Atherosclerosis. Supplements, , Volume: 30, 2017

ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL inhibition in mastitis mice.
Experimental and molecular pathology, , Volume: 103, Issue:3, 2017

Caryocar coriaceum Wittm. (Pequi) fixed oil presents hypolipemic and anti-inflammatory effects in vivo and in vitro.
Journal of ethnopharmacology, , Sep-15, Volume: 191, 2016

Role of Myeloperoxidase in Patients with Chronic Kidney Disease.
Oxidative medicine and cellular longevity, , Volume: 2016, 2016

A low-frequency variant in MAPK14 provides mechanistic evidence of a link with myeloperoxidase: a prognostic cardiovascular risk marker.
Journal of the American Heart Association, , Aug-27, Volume: 3, Issue:4, 2014

Serum Fetuin-A levels, insulin resistance and oxidative stress in women with polycystic ovary syndrome.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, , Volume: 29, Issue:12, 2013

Leukocyte and leukocyte subset counts reveal compensatory mechanisms in coronary heart disease.
Clinica chimica acta; international journal of clinical chemistry, , Mar-15, Volume: 418, 2013

Myeloperoxidase overexpression in children with hypercholesterolemia.
Atherosclerosis, , Volume: 205, Issue:1, 2009

Dysfunctional high-density lipoprotein.
Current opinion in endocrinology, diabetes, and obesity, , Volume: 16, Issue:2, 2009

Fraxetin prevented sodium fluoride-induced chronic pancreatitis in rats: Role of anti-inflammatory, antioxidant, antifibrotic and anti-apoptotic activities.
International immunopharmacology, , Volume: 93, 2021

Fibroblast growth factor 21 ameliorates pancreatic fibrogenesis via regulating polarization of macrophages.
Experimental cell research, , 09-01, Volume: 382, Issue:1, 2019

[The role of oxidative inflammatory cascade on pancreatic fibrosis progression in mice induced by DBTC plus ethanol].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, , Volume: 31, Issue:5, 2015

TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis.
The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-27, Volume: 33, Issue:13, 2013

Effect of thymoquinone on ethanol and high fat diet induced chronic pancreatitis--a dose response study in rats.
Indian journal of experimental biology, , Volume: 51, Issue:4, 2013

Exenatide-induced chronic damage of pancreatic tissue in rats.
Pancreas, , Volume: 41, Issue:8, 2012

Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor.
Pancreas, , Volume: 39, Issue:1, 2010

FTY720, an immunosuppressant, attenuates chronic pancreatitis in rats by suppressing T-cell infiltration.
Pancreas, , Volume: 30, Issue:3, 2005

Cumulative effects of bone and soft tissue injury on systemic inflammation: a pilot study.
Clinical orthopaedics and related research, , Volume: 471, Issue:9, 2013

A patient with intravascular lymphoma presenting with cerebral infarction and a high serum MPO-ANCA level.
Modern rheumatology, , Volume: 21, Issue:2, 2011

Myeloperoxidase is Independently Associated with Incident Heart Failure in Patients with Coronary Artery Disease and Kidney Disease.
Current problems in cardiology, , Volume: 47, Issue:11, 2022

Inflammation, Lymphatics, and Cardiovascular Disease: Amplification by Chronic Kidney Disease.
Current hypertension reports, , Volume: 24, Issue:10, 2022

Myeloperoxidase: Indicator of cardiovascular disease in chronic kidney disease patients of tertiary care hospital of Karachi.
JPMA. The Journal of the Pakistan Medical Association, , Volume: 71, Issue:4, 2021

Serum Myeloperoxidase, Uric Acid, and the Risk of Atrial Fibrillation in Chronic Kidney Disease.
Circulation. Arrhythmia and electrophysiology, , Volume: 14, Issue:4, 2021

Polyangiitis overlap syndrome: a novel presentation of microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis.
BMJ case reports, , Feb-01, Volume: 14, Issue:2, 2021

Hyperuricemia is associated with decreased renal function and occurrence of end-stage renal disease in patients with microscopic polyangiitis and granulomatosis with polyangiitis: a retrospective study.
Rheumatology international, , Volume: 40, Issue:7, 2020

Gastrointestinal and renal involvement in systemic vasculitis.
Revista espanola de enfermedades digestivas, , Volume: 112, Issue:12, 2020

Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis.
Renal failure, , Volume: 40, Issue:1, 2018

The effect of n-3 fatty acids and coenzyme Q10 supplementation on neutrophil leukotrienes, mediators of inflammation resolution and myeloperoxidase in chronic kidney disease.
Prostaglandins & other lipid mediators, , Volume: 136, 2018

Myeloperoxidase Levels and Its Product 3-Chlorotyrosine Predict Chronic Kidney Disease Severity and Associated Coronary Artery Disease.
American journal of nephrology, , Volume: 46, Issue:1, 2017

Myeloperoxidase Activity and Oxidized Amino Acids as Biomarkers in Chronic Kidney Disease and Coronary Artery Disease.
American journal of nephrology, , Volume: 46, Issue:1, 2017

Effect of Vitamin D Receptor Activation on the AGE/RAGE System and Myeloperoxidase in Chronic Kidney Disease Patients.
Oxidative medicine and cellular longevity, , Volume: 2017, 2017

ANCA and IgA glomerulonephritis all in one: prognosis and complications.
BMJ case reports, , Oct-09, Volume: 2017, 2017

Role of Myeloperoxidase in Patients with Chronic Kidney Disease.
Oxidative medicine and cellular longevity, , Volume: 2016, 2016

Serum levels of the soluble haemoglobin scavenger receptor CD163 in MPO-ANCA-associated renal vasculitis.
Scandinavian journal of rheumatology, , Volume: 45, Issue:5, 2016

Plasma Nitration of High-Density and Low-Density Lipoproteins in Chronic Kidney Disease Patients Receiving Kidney Transplants.
Mediators of inflammation, , Volume: 2015, 2015

Treatment of severe renal disease in ANCA positive and negative small vessel vasculitis with rituximab.
American journal of nephrology, , Volume: 41, Issue:4-5, 2015

Myeloperoxidase in chronic kidney disease: role of visceral fat.
Nephrology (Carlton, Vic.), , Volume: 19, Issue:3, 2014

The uremic toxin indoxyl sulfate acts as a pro- or antioxidant on LDL oxidation.
Free radical research, , Volume: 48, Issue:6, 2014

Association of low serum complement C3 with reduced patient and renal survival in antimyeloperoxidase-associated small-vessel vasculitis.
Nephron. Clinical practice, , Volume: 126, Issue:1, 2014

Myeloperoxidase deficiency ameliorates progression of chronic kidney disease in mice.
American journal of physiology. Renal physiology, , Aug-15, Volume: 307, Issue:4, 2014

Protein oxidation in chronic kidney disease.
Clinical hemorheology and microcirculation, , Volume: 54, Issue:4, 2013

ApoA-1 mimetic peptide reverses uremia-induced upregulation of pro-atherogenic pathways in the aorta.
American journal of nephrology, , Volume: 32, Issue:3, 2010

Associations between the CYBA 242C/T and the MPO -463G/A polymorphisms, oxidative stress and cardiovascular disease in chronic kidney disease patients.
Blood purification, , Volume: 25, Issue:2, 2007

Deletion of bone marrow myeloperoxidase attenuates chronic kidney disease accelerated atherosclerosis.
The Journal of biological chemistry, , Volume: 296

Relationship of epicardial fat tissue thickness with oxidant biomarkers in chronic kidney disease.
Bratislavske lekarske listy, , Volume: 119, Issue:9

Diffuse alveolar haemorrhage associated with subsequent development of ANCA positivity and emphysema in three young adults.
BMC pulmonary medicine, , Oct-24, Volume: 19, Issue:1, 2019

An Elderly Man with Fatigue, Dyspnea, and Kidney Failure.
Clinical journal of the American Society of Nephrology : CJASN, , 05-08, Volume: 12, Issue:5, 2017

Successful Management of Lupus Nephritis with High Titers of Myeloperoxidase Anti-Neutrophil Cytoplasmic Antibodies Using Tacrolimus.
Internal medicine (Tokyo, Japan), , Volume: 54, Issue:22, 2015

Chronic pulmonary bleeding as the first sign of microscopic polyangiitis associated with autoimmune thyroiditis.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, , Volume: 31, Issue:4, 2011

Mesenteric lymph duct ligation against renal injury in rats after hemorrhagic shock.
Renal failure, , Volume: 32, Issue:5, 2010

Interstitial Foxp3-positive T cells may predict renal survival in patients with myeroperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.
Clinical and experimental pharmacology & physiology, , Volume: 37, Issue:9, 2010

Remote renal injury following partial hepatic ischemia/reperfusion injury in rats.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, , Volume: 12, Issue:3, 2008

The effects of ginkgo biloba extract on tissue adenosine deaminase, xanthine oxidase, myeloperoxidase, malondialdehyde, and nitric oxide in cisplatin-induced nephrotoxicity.
Toxicology and industrial health, , Volume: 22, Issue:3, 2006

Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis in scleroderma--a different kind of renal crisis.
The Journal of rheumatology, , Volume: 33, Issue:9, 2006

Systemic cholesterol embolization syndrome associated with myeloperoxidase-anti-neutrophil cytoplasmic antibody.
Internal medicine (Tokyo, Japan), , Volume: 45, Issue:8, 2006

Primed peripheral polymorphonuclear leukocyte: a culprit underlying chronic low-grade inflammation and systemic oxidative stress in chronic kidney disease.
Journal of the American Society of Nephrology : JASN, , Volume: 16, Issue:8, 2005

Peroxisome proliferator-activated receptor beta/delta exerts a strong protection from ischemic acute renal failure.
Journal of the American Society of Nephrology : JASN, , Volume: 16, Issue:8, 2005

[Clinical and pathological characterization of antineutrophil cytoplasmic antibody associated small vasculitis in children].
Zhonghua er ke za zhi = Chinese journal of pediatrics, , Volume: 42, Issue:6, 2004

Biochemical and spectrophotometric significance of advanced oxidized protein products.
Biochimica et biophysica acta, , Jun-28, Volume: 1689, Issue:2, 2004

Effect of N-acetylcysteine on gentamicin-mediated nephropathy in rats.
European journal of pharmacology, , Jul-13, Volume: 424, Issue:1, 2001

Myeloperoxidase-catalyzed 3-chlorotyrosine formation in dialysis patients.
Free radical biology & medicine, , Nov-15, Volume: 31, Issue:10, 2001

The significance of antineutrophil cytoplasmic antibody in microscopic polyangitis and classic polyarteritis nodosa.
Archives of disease in childhood, , Volume: 85, Issue:5, 2001

MPO-ANCA-Positive crescentic glomerulonephritis: a distinct entity of scleroderma renal disease?
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 33, Issue:4, 1999

Sensitive enzymatic assay for erythrocyte creatine with production of methylene blue.
Clinical chemistry, , Volume: 44, Issue:7, 1998

Scleroderma, D-penicillamine treatment, and progressive renal failure associated with positive antimyeloperoxidase antineutrophil cytoplasmic antibodies.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 30, Issue:2, 1997

Thiazide-induced kidney damage with circulating antibodies against myeloperoxidase and cardiolipin.
Journal of internal medicine, , Volume: 233, Issue:6, 1993

Manifest interstitial and vascular pathology in anti-neutrophil cytoplasmic antibody-associated renal disease.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, , Volume: 30, Issue:3

The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study.
International braz j urol : official journal of the Brazilian Society of Urology, , Volume: 43, Issue:2

[Progressive systemic sclerosis associated with anti-myeloperoxidase ANCA vasculitis with renal and cutaneous involvement].
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, , Volume: 20, Issue:4

Enzyme activities in the oral fluids of patients suffering from bulimia: a controlled clinical trial.
Caries research, , Volume: 46, Issue:2, 2012

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Early increase of VEGF-A is associated with resolution of ventilator-associated pneumonia: Clinical and experimental evidence.
Respirology (Carlton, Vic.), , Volume: 23, Issue:10, 2018

Neutrophil extracellular traps (NETs) are increased in the alveolar spaces of patients with ventilator-associated pneumonia.
Critical care (London, England), , 12-27, Volume: 22, Issue:1, 2018

Neutrophil degranulation biomarkers characterize restrictive echocardiographic pattern with diastolic dysfunction in patients with diabetes.
European journal of clinical investigation, , Volume: 51, Issue:12, 2021

Integrating plasma high-sensitivity C-reactive protein and myeloperoxidase for risk prediction in chronic systolic heart failure.
Congestive heart failure (Greenwich, Conn.), , Volume: 17, Issue:3

Neutrophil degranulation biomarkers characterize restrictive echocardiographic pattern with diastolic dysfunction in patients with diabetes.
European journal of clinical investigation, , Volume: 51, Issue:12, 2021

Myeloperoxidase, a possible biomarker for the early diagnosis of cardiac diastolic dysfunction with preserved ejection fraction.
Journal of enzyme inhibition and medicinal chemistry, , Volume: 33, Issue:1, 2018

Pathways of Neutrophil Granulocyte Activation in Hereditary Angioedema with C1 Inhibitor Deficiency.
Clinical reviews in allergy & immunology, , Volume: 60, Issue:3, 2021

Early T-cell precursor acute lymphoblastic leukemia with Auer rods-A case report.
International journal of laboratory hematology, , Volume: 42, Issue:1, 2020

[Value of CD, MPO, Ki-67 and C-MYC Positive Rate in the Pathological Tissues and C-MYC Gene of Patients with T-LBL/ALL for Predicting Prognosis].
Zhongguo shi yan xue ye xue za zhi, , Volume: 26, Issue:1, 2018

Lymphoblastic lymphoma with unusual cytological features in pericardial effusion fluid.
Cytopathology : official journal of the British Society for Clinical Cytology, , Volume: 23, Issue:1, 2012

CD117 expression is a sensitive but nonspecific predictor of FLT3 mutation in T acute lymphoblastic leukemia and T/myeloid acute leukemia.
American journal of clinical pathology, , Volume: 137, Issue:2, 2012

Rapid aortic and mitral valve thickening and regurgitation with complete atrioventricular block due to myeloperoxidase anti-neutrophil cytoplasmic antibody-associated vasculitis.
Journal of echocardiography, , Volume: 19, Issue:3, 2021

Incidence and risk factors of venous thromboembolism in ANCA-associated vasculitis: a metaanalysis and metaregression.
Clinical rheumatology, , Volume: 40, Issue:7, 2021

Association of Pulmonary Hemorrhage, Positive Proteinase 3, and Urinary Red Blood Cell Casts With Venous Thromboembolism in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Arthritis & rheumatology (Hoboken, N.J.), , Volume: 71, Issue:11, 2019

Histological criteria for age determination of fatal venous thromboembolism.
International journal of legal medicine, , Volume: 132, Issue:3, 2018

Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development.
Journal of thrombosis and haemostasis : JTH, , Volume: 12, Issue:6, 2014

Prognostic value of radiological findings indeterminate for UIP pattern and anterior upper lobe honeycomb-like lesion in chronic fibrosing interstitial lung disease associated with MPO-ANCA.
BMC pulmonary medicine, , Nov-03, Volume: 21, Issue:1, 2021

Antineutrophil cytoplasmic antibody-associated interstitial lung disease: a review.
European respiratory review : an official journal of the European Respiratory Society, , Dec-31, Volume: 30, Issue:162, 2021

Risk of progression of idiopathic pulmonary fibrosis to connective tissue disease: a long-term observational study in 527 patients.
Clinical rheumatology, , Volume: 40, Issue:6, 2021

Relationship Between Combination of Pulmonary Fibrosis and Emphysema, ANCA, and Vasculitis.
Chest, , Volume: 158, Issue:3, 2020

Prognosis of pulmonary fibrosis presenting with a usual interstitial pneumonia pattern on computed tomography in patients with myeloperoxidase anti-neutrophil cytoplasmic antibody-related nephritis: a retrospective single-center study.
BMC pulmonary medicine, , Nov-01, Volume: 19, Issue:1, 2019

Systematic review and meta-analysis of clinical significance of autoantibodies for idiopathic pulmonary fibrosis.
BMJ open, , 05-29, Volume: 9, Issue:5, 2019

Prevalence and Clinical Significance of Antineutrophil Cytoplasmic Antibodies in North American Patients With Idiopathic Pulmonary Fibrosis.
Chest, , Volume: 156, Issue:4, 2019

From fibrosis to diagnosis: a paediatric case of microscopic polyangiitis and review of the literature.
Rheumatology international, , Volume: 38, Issue:4, 2018

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

Prevalence and Responsiveness to Treatment of Lung Abnormalities on Chest Computed Tomography in Patients With Microscopic Polyangiitis: A Multicenter, Longitudinal, Retrospective Study of One Hundred Fifty Consecutive Hospital-Based Japanese Patients.
Arthritis & rheumatology (Hoboken, N.J.), , Volume: 68, Issue:3, 2016

Clinical features of usual interstitial pneumonia with anti-neutrophil cytoplasmic antibody in comparison with idiopathic pulmonary fibrosis.
Respirology (Carlton, Vic.), , Volume: 21, Issue:5, 2016

Amelioration of bleomycin-induced pulmonary fibrosis in a mouse model by a combination therapy of bosentan and imatinib.
Experimental lung research, , Volume: 41, Issue:4, 2015

Idiopathic lung fibrosis and anti myeloperoxidase glomerulonephritis: the tree that hides the forest.
BMC pulmonary medicine, , Oct-26, Volume: 15, 2015

Incidence of myeloperoxidase anti-neutrophil cytoplasmic antibody positivity and microscopic polyangitis in the course of idiopathic pulmonary fibrosis.
Respiratory medicine, , Volume: 107, Issue:4, 2013

Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency.
Blood, , 06-23, Volume: 127, Issue:25, 2016

JAK2-positive cutaneous myelofibrosis presenting as sclerosing extramedullary hematopoietic tumors on the scalp: case presentation and review of the literature.
Journal of cutaneous pathology, , Volume: 42, Issue:11, 2015

Extramedullary hematopoiesis of the conjunctiva presenting as active systemic disease in a patient with myelofibrosis.
Cornea, , Volume: 33, Issue:12, 2014

Bone marrow changes induced by recombinant granulocyte colony-stimulating factor resembling metastatic carcinoma: distinction with cytochemical and immunohistochemical studies.
American journal of hematology, , Volume: 51, Issue:4, 1996

Cell surface phenotyping of megakaryoblasts.
Blood, , Volume: 69, Issue:3, 1987

Myeloperoxidase-deficient polymorphonuclear leucocytes (VII): Incidence in untreated myeloproliferative disorders.
Scandinavian journal of haematology, , Volume: 36, Issue:1, 1986

Impaired metabolic activity of phagocytosing neutrophils in agnogenic osteomyelofibrosis with splenomegaly: a longitudinal study.
American journal of hematology, , Volume: 16, Issue:3, 1984

[A case of primary myelofibrosis terminating in acute megakaryoblastic leukemia: identification by the demonstration of platelet peroxidase].
[Rinsho ketsueki] The Japanese journal of clinical hematology, , Volume: 25, Issue:3, 1984

Megakaryoblastic leukemia presenting as acute myelofibrosis -- a study of four cases with the platelet-peroxidase reaction.
Blood, , Volume: 58, Issue:2, 1981

Impaired neutrophil function and myeloperoxidase deficiency in myeloid metaplasia.
British journal of haematology, , Volume: 37, Issue:3, 1977

Idiopathic myelofibrosis with neutrophil myeloperoxidase deficiency: a case report.
Haematologica, , Volume: 82, Issue:4

Combination of HDAC and topoisomerase inhibitors in small cell lung cancer.
Cancer biology & therapy, , Volume: 13, Issue:8, 2012

Combinations of DNA methyltransferase and histone deacetylase inhibitors induce DNA damage in small cell lung cancer cells: correlation of resistance with IFN-stimulated gene expression.
Molecular cancer therapeutics, , Volume: 9, Issue:8, 2010

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

[no title available]
Obstetrics and gynecology research, , Volume: 5, 2022

An Autopsy Case of Myeloperoxidase-anti-neutrophil Cytoplasmic Antibody (MPO-ANCA)-associated Vasculitis Accompanied by Cryoglobulinemic Vasculitis Affecting the Kidneys, Skin, and Gastrointestinal Tract.
Internal medicine (Tokyo, Japan), , Sep-15, Volume: 57, Issue:18, 2018

Pulmonary Involvement in Systemic Vasculitis.
Current rheumatology reports, , Volume: 19, Issue:9, 2017

Acute ST elevation myocardial infarction in fulminant systemic p-ANCA vasculitis: a rare catastrophic complication.
BMJ case reports, , Jun-29, Volume: 2016, 2016

Myeloperoxidase-antineutrophil Cytoplasmic Antibodies (MPO-ANCA) and Proteinase 3-ANCA without Immunofluorescent ANCA Found by Routine Clinical Testing.
The Journal of rheumatology, , Volume: 42, Issue:5, 2015

Susceptibility quantitative trait loci for pathogenic leucocytosis in SCG/Kj mice, a spontaneously occurring crescentic glomerulonephritis and vasculitis model.
Clinical and experimental immunology, , Volume: 177, Issue:1, 2014

Anti-neutrophil cytoplasmic autoantibodies: methodological aspects and clinical significance in systemic vasculitis.
Autoimmunity reviews, , Volume: 12, Issue:4, 2013

Coexistence of anti-GBM antibodies and MPO-ANCA in a patient with systemic vasculitis and crescentic glomerulonephritis.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, , Volume: 30, Issue:6, 2010

Potential anti-inflammatory effect of low-level laser therapy on the experimental reflux laryngitis: a preliminary study.
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Predictive modeling and inflammatory biomarkers in rats with lung contusion and gastric aspiration.
The Journal of trauma, , Volume: 67, Issue:6, 2009

Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies.
Blood, , Aug-09, Volume: 120, Issue:6, 2012

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Blood, , Aug-09, Volume: 120, Issue:6, 2012

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

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Neutrophil degranulation biomarkers characterize restrictive echocardiographic pattern with diastolic dysfunction in patients with diabetes.
European journal of clinical investigation, , Volume: 51, Issue:12, 2021

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The ARIC carotid MRI study of blood cellular markers: an inverse association of monocyte myeloperoxidase content with peripheral arterial disease.
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Characterization of cerebral small vessel disease by neutrophil and platelet activation markers using artificial intelligence.
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Occurrence of cerebral small vessel disease at diagnosis of MPO-ANCA-associated vasculitis.
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Detection of Neutrophils in the Sciatic Nerve Following Peripheral Nerve Injury.
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Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration.
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Lack of interleukin-17 leads to a modulated micro-environment and amelioration of mechanical hypersensitivity after peripheral nerve injury in mice.
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Neuroprotective effect of melatonin on experimental peripheral nerve injury: an electron microscopic and biochemical study.
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Glucantime reduces mechanical hyperalgesia in cutaneous leishmaniasis and complete Freund's adjuvant models of chronic inflammatory pain.
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Acute and chronic nociceptive phases observed in a rat hind paw ischemia/reperfusion model depend on different mechanisms.
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Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice.
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Effect of eptifibatide on inflammation during acute pain episodes in sickle cell disease.
American journal of hematology, , Volume: 93, Issue:4, 2018

Acute and chronic nociceptive phases observed in a rat hind paw ischemia/reperfusion model depend on different mechanisms.
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New anthranilic acid derivative, EAntS-GS, attenuates Freund's complete adjuvant-induced acute pain in rats.
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Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndrome patients.
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Local Matrix Metalloproteinase 9 Level Determines Early Clinical Presentation of ST-Segment-Elevation Myocardial Infarction.
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[Myeloperoxidase activity in blood plasma as a criterion of therapy for patients with cardiovascular disease].
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Polyunsaturated omega-3 fatty acids reduce lipoprotein-associated phospholipase A(2) in patients with stable angina.
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Fungal antioxidant pathways promote survival against neutrophils during infection.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Effect of Training-Detraining Phases of Multicomponent Exercises and BCAA Supplementation on Inflammatory Markers and Albumin Levels in Frail Older Persons.
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Lipoic Acid and Fish Oil Combination Potentiates Neuroinflammation and Oxidative Stress Regulation and Prevents Cognitive Decline of Rats After Sepsis.
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Peroxidase-Mimicking Nanoassembly Mitigates Lipopolysaccharide-Induced Endotoxemia and Cognitive Damage in the Brain by Impeding Inflammatory Signaling in Macrophages.
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ERK Signaling Pathway Plays a Key Role in Baicalin Protection Against Acetaminophen-Induced Liver Injury.
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Myeloperoxidase-positive ANCA-associated vasculitis presenting as myalgia, proximal weakness and a normal CK.
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Neutrophil and monocyte responses to downhill running: Intracellular contents of MPO, IL-6, IL-10, pstat3, and SOCS3.
Scandinavian journal of medicine & science in sports, , Volume: 26, Issue:6, 2016

Variable inflammation and intramuscular STAT3 phosphorylation and myeloperoxidase levels after downhill running.
Scandinavian journal of medicine & science in sports, , Volume: 24, Issue:5, 2014

Role of TNF-α/TNFR1 in intense acute swimming-induced delayed onset muscle soreness in mice.
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Apremilast ameliorates carfilzomib-induced pulmonary inflammation and vascular injuries.
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Adverse events and infectious burden, microbes and temporal outline from immunosuppressive therapy in antineutrophil cytoplasmic antibody-associated vasculitis with native renal function.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 30 Suppl 1, 2015

[Study of clinical effect on treatment of chronic obstructive pulmonary disease in acute aggravated stage with Tanreqing injection and cell factor level].
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Genetic basis of toxic reactions to drugs and chemicals.
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Haematologica, , Volume: 34, Issue:6, 1950

IgA Fc-folate conjugate activates and recruits neutrophils to directly target triple-negative breast cancer cells.
Breast cancer research and treatment, , Volume: 172, Issue:3, 2018

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury.
The Journal of clinical investigation, , Volume: 122, Issue:7, 2012

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Bioactive substance accumulation and septic complications in a burn trauma patient: effect of perioperative blood transfusion?
Burns : journal of the International Society for Burn Injuries, , Volume: 23, Issue:1, 1997

Inflammatory signature in acute-on-chronic liver failure includes increased expression of granulocyte genes ELANE, MPO and CD177.
Scientific reports, , 09-22, Volume: 11, Issue:1, 2021

Mesenchymal Stromal Cells Inhibit Neutrophil Effector Functions in a Murine Model of Ocular Inflammation.
Investigative ophthalmology & visual science, , 03-01, Volume: 59, Issue:3, 2018

Resolvin D1 promotes corneal epithelial wound healing and restoration of mechanical sensation in diabetic mice.
Molecular vision, , Volume: 24, 2018

Targeted suppression of HO-2 gene expression impairs the innate anti-inflammatory and repair responses of the cornea to injury.
Molecular vision, , Apr-29, Volume: 17, 2011

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Myeloperoxidase-Sensitive
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease.
American journal of physiology. Gastrointestinal and liver physiology, , Oct-01, Volume: 323, Issue:4, 2022

A Nutraceutical Formulation Containing Brown Algae Reduces Hepatic Lipid Accumulation by Modulating Lipid Metabolism and Inflammation in Experimental Models of NAFLD and NASH.
Marine drugs, , Sep-08, Volume: 20, Issue:9, 2022

Fortifying Butterfat with Soybean Oil Attenuates the Onset of Diet-Induced Non-Alcoholic Steatohepatitis and Glucose Intolerance.
Nutrients, , Mar-16, Volume: 13, Issue:3, 2021

Myeloperoxidase and calprotectin; Any role as non-invasive markers for the prediction of ınflammation and fibrosis in non-alcoholic steatohepatitis?
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, , Volume: 31, Issue:10, 2020

Pharmacological myeloperoxidase (MPO) inhibition in an obese/hypertensive mouse model attenuates obesity and liver damage, but not cardiac remodeling.
Scientific reports, , 12-10, Volume: 9, Issue:1, 2019

Repression of TXNIP-NLRP3 axis restores intestinal barrier function via inhibition of myeloperoxidase activity and oxidative stress in nonalcoholic steatohepatitis.
Journal of cellular physiology, , Volume: 234, Issue:5, 2019

Butein protects the nonalcoholic fatty liver through mitochondrial reactive oxygen species attenuation in rats.
BioFactors (Oxford, England), , Volume: 44, Issue:3, 2018

Molecular MR Imaging of Myeloperoxidase Distinguishes Steatosis from Steatohepatitis in Nonalcoholic Fatty Liver Disease.
Radiology, , Volume: 284, Issue:2, 2017

Oxidative Stress as a Critical Factor in Nonalcoholic Fatty Liver Disease Pathogenesis.
Antioxidants & redox signaling, , 04-01, Volume: 26, Issue:10, 2017

Advanced Glycation End Products Induce Obesity and Hepatosteatosis in CD-1 Wild-Type Mice.
BioMed research international, , Volume: 2016, 2016

Myeloperoxidase-Hepatocyte-Stellate Cell Cross Talk Promotes Hepatocyte Injury and Fibrosis in Experimental Nonalcoholic Steatohepatitis.
Antioxidants & redox signaling, , Dec-01, Volume: 23, Issue:16, 2015

Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes.
The Journal of nutritional biochemistry, , Volume: 23, Issue:4, 2012

Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice.
PloS one, , Volume: 7, Issue:12, 2012

Redox balance in the pathogenesis of nonalcoholic fatty liver disease: mechanisms and therapeutic opportunities.
Antioxidants & redox signaling, , Sep-01, Volume: 15, Issue:5, 2011

An experimental research on chronic intermittent hypoxia leading to liver injury.
Sleep & breathing = Schlaf & Atmung, , Volume: 15, Issue:3, 2011

The effect of hepatic ischemia reperfusion injury in a murine model of nonalcoholic steatohepatitis.
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Distinct patterns of soluble leukocyte activation markers are associated with etiology and outcomes in precapillary pulmonary hypertension.
Scientific reports, , 10-29, Volume: 10, Issue:1, 2020

Myeloperoxidase activity as a lung injury marker in the lamb model of congenital diaphragmatic hernia.
Journal of pediatric surgery, , Volume: 36, Issue:2, 2001

[Expression of eosinophilic cationic protein in neutrophils and its effect on objective evaluation of nasal inflammation].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, , Volume: 33, Issue:7, 2019

Airway inflammatory responses to diesel exhaust in allergic rhinitics.
Inhalation toxicology, , Volume: 25, Issue:3, 2013

Differences in the behavior of advanced glycation end products and advanced oxidation protein products in patients with allergic rhinitis.
Journal of investigational allergology & clinical immunology, , Volume: 23, Issue:2, 2013

Galectin-3 and Myeloperoxidase May Monitor Cancer-Therapy-Related Cardiotoxicity? A Systematic Review and Meta-Analysis.
Biomolecules, , 11-30, Volume: 12, Issue:12, 2022

Cardiac monitoring in HER2-positive patients on trastuzumab treatment: A review and implications for clinical practice.
Breast (Edinburgh, Scotland), , Volume: 52, 2020

Changes in Cardiovascular Biomarkers With Breast Cancer Therapy and Associations With Cardiac Dysfunction.
Journal of the American Heart Association, , 01-21, Volume: 9, Issue:2, 2020

[Сurrent views on predictors and biomarkers of early diagnosis of anthracycline-mediated cardiotoxicity in patients with breast cancer (review of literature).]
Klinicheskaia laboratornaia diagnostika, , Volume: 65, Issue:3, 2020

Cardioprotective Effects of Atorvastatin Are Mediated Through PPARγ in Paraquat-Exposed Rats.
Journal of cardiovascular pharmacology, , Volume: 74, Issue:5, 2019

Strategies for early detection of cardiotoxicities from anticancer therapy in adults: evolving imaging techniques and emerging serum biomarkers.
Future oncology (London, England), , Volume: 11, Issue:14, 2015

Mechanisms underlying reduced expulsion of a murine nematode infection during protein deficiency.
Parasitology, , Volume: 135, Issue:Pt 1, 2008

Neonatal maternal deprivation promotes Nippostrongylus brasiliensis infection in adult rats.
Brain, behavior, and immunity, , Volume: 20, Issue:3, 2006

Alterations of neurokinin receptors and interstitial cells of Cajal during and after jejunal inflammation induced by Nippostrongylus brasiliensis in the rat.
Neurogastroenterology and motility, , Volume: 14, Issue:1, 2002

Development and sequels of intestinal inflammation in nematode-infected rats: role of mast cells and capsaicin-sensitive afferents.
Neuroimmunomodulation, , Volume: 8, Issue:4, 2000

Brain Fos expression and intestinal motor alterations during nematode-induced inflammation in the rat.
The American journal of physiology, , Volume: 274, Issue:1, 1998

Effects of nematode infection on sensitivity to intestinal distension: role of tachykinin NK2 receptors.
European journal of pharmacology, , Oct-22, Volume: 337, Issue:2-3, 1997

Size-controlled preparation of peroxidase-like graphene-gold nanoparticle hybrids for the visible detection of norovirus-like particles.
Biosensors & bioelectronics, , Jan-15, Volume: 87, 2017

Selected indices of non-specific humoral immunity in rabbits experimentally infected with non-hemagglutinogenic strain of VHD (viral hemorrhagic disease) virus.
Polish journal of veterinary sciences, , Volume: 6, Issue:3 Suppl, 2003

Myeloperoxidase-positive bilineal mixed phenotype acute leukemia (B/T) with chromosome copy neutral loss of heterozygosity exhibits simultaneous diffuse leukemic infiltrations in the lung, bone, and endorachis.
Pediatric blood & cancer, , Volume: 70, Issue:2, 2023

Bullous lesion with central umbilication in leukemia.
International journal of dermatology, , Volume: 53, Issue:2, 2014

Leukemia cutis from CD56 positive, myeloperoxidase negative acute myeloid leukemia.
Acta dermatovenerologica Croatica : ADC, , Volume: 21, Issue:3, 2013

Utility of myeloperoxidase stain in the differential diagnosis of leukemia cutis vs. hystiocitoid Sweet syndrome.
Dermatology online journal, , Apr-15, Volume: 17, Issue:4, 2011

Intraoral granulocytic sarcoma: a case report and review of the literature.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, , Volume: 68, Issue:10, 2010

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Applied immunohistochemistry & molecular morphology : AIMM, , Volume: 18, Issue:2, 2010

Leukemia cutis.
American journal of clinical pathology, , Volume: 129, Issue:1, 2008

Acute myeloid leukemia presenting as non-neutropenic colitis in an infant.
Journal of pediatric gastroenterology and nutrition, , Volume: 37, Issue:5, 2003

Therapy-related leukemia cutis: case study of an aggressive disorder.
Annals of hematology, , Volume: 82, Issue:11, 2003

Acute myeloid leukemia mimicking primary testicular neoplasm. Presentation of a case with review of literature.
European journal of haematology, , Volume: 70, Issue:4, 2003

Pathologic diagnosis of acute lymphocytic leukemia.
Hematology/oncology clinics of North America, , Volume: 14, Issue:6, 2000

CD56+ blastic transformation of chronic myeloid leukemia involving the skin.
Journal of cutaneous pathology, , Volume: 26, Issue:10, 1999

Skin infiltration in acute promyelocytic leukemia.
Dermatology (Basel, Switzerland), , Volume: 194, Issue:2, 1997

High- density lipoprotein function is abnormal in idiopathic inflammatory myopathies.
Rheumatology (Oxford, England), , 11-01, Volume: 59, Issue:11, 2020

Neutrophil extracellular traps activate lung fibroblast to induce polymyositis-related interstitial lung diseases via TLR9-miR-7-Smad2 pathway.
Journal of cellular and molecular medicine, , Volume: 24, Issue:2, 2020

Immunoglobulin isotypes of anti-myeloperoxidase and anti-lactoferrin antibodies in patients with collagen diseases.
Journal of clinical immunology, , Volume: 20, Issue:4, 2000

Nuclear transcription factor-kappa beta-dependent ultrastructural alterations within the placenta and systemic inflammatory activation in pregnant patients with hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndrome: a case-control
Hypertension in pregnancy, , Volume: 32, Issue:3, 2013

Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes.
Cardiovascular research, , 01-29, Volume: 118, Issue:2, 2022

Pharmacological myeloperoxidase (MPO) inhibition in an obese/hypertensive mouse model attenuates obesity and liver damage, but not cardiac remodeling.
Scientific reports, , 12-10, Volume: 9, Issue:1, 2019

[Simultaneous presence of antibodies against the glomerular basement membrane and anti-myeloperoxidase antibodies in 2 patients with rapidly progressive glomerulonephritis].
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, , Volume: 22, Issue:2, 2002

Early inflammatory response during the development of right ventricular heart failure in a rat model.
European journal of heart failure, , Volume: 12, Issue:7, 2010

Exacerbated and prolonged inflammation impairs wound healing and increases scarring.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , Volume: 24, Issue:1

Differential clinicopathologic features of EGPA-associated neuropathy with and without ANCA.
Neurology, , 04-21, Volume: 94, Issue:16, 2020

Clinical and histopathologic features of 8 patients with microscopic polyangiitis including two with a slowly progressive clinical course.
Journal of the American Academy of Dermatology, , Volume: 57, Issue:5, 2007

Systemic cholesterol embolization syndrome associated with myeloperoxidase-anti-neutrophil cytoplasmic antibody.
Internal medicine (Tokyo, Japan), , Volume: 45, Issue:8, 2006

Methimazole-induced pulmonary hemorrhage associated with antimyeloperoxidase-antineutrophil cytoplasmic antibody: a case report.
Journal of the Formosan Medical Association = Taiwan yi zhi, , Volume: 100, Issue:11, 2001

Minocycline induced arthritis associated with fever, livedo reticularis, and pANCA.
Annals of the rheumatic diseases, , Volume: 55, Issue:10, 1996

Tobacco differentially affects the clinical-biological phenotypes of ANCA-associated vasculitides.
Clinical and experimental rheumatology, , Volume: 33, Issue:2 Suppl 89

Anti-neutrophil cytoplasmic antibodies in 566 European patients with systemic lupus erythematosus: prevalence, clinical associations and correlation with other autoantibodies. European Concerted Action on the Immunogenetics of SLE.
Clinical and experimental rheumatology, , Volume: 16, Issue:5

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis.
Journal of visualized experiments : JoVE, , 09-26, Issue:187, 2022

Neutrophil-Derived Myeloperoxidase Facilitates Both the Induction and Elicitation Phases of Contact Hypersensitivity.
Frontiers in immunology, , Volume: 11, 2020

Percutaneous toxicity of dinitrochlorobenzene (DNCB) in rats.
Cutaneous and ocular toxicology, , Volume: 31, Issue:1, 2012

The incorporation of lysine into the peroxidase peptide reactivity assay for skin sensitization assessments.
Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 122, Issue:2, 2011

Effect of orally administered Eriobotrya japonica seed extract on allergic contact dermatitis in rats.
The Journal of pharmacy and pharmacology, , Volume: 59, Issue:10, 2007

Lipoxygenase-catalyzed polymerization of phenolic lipids suggests a new mechanism for allergic contact dermatitis induced by urushiol and its analogs.
Biochemical and biophysical research communications, , Mar-12, Volume: 315, Issue:3, 2004

Simvastatin ointment, a new treatment for skin inflammatory conditions.
Journal of dermatological science, , Volume: 66, Issue:2, 2012

Differential cytokine expression in skin after single and repeated irritation by sodium lauryl sulphate.
Experimental dermatology, , Volume: 16, Issue:12, 2007

Topical application of a novel immunomodulatory peptide, RDP58, reduces skin inflammation in the phorbol ester-induced dermatitis model.
The Journal of investigative dermatology, , Volume: 125, Issue:3, 2005

The possible neurobehavioral protective effects of natural antioxidant against phototoxicity attenuation of antimicrobial quinolone group in rats.
Journal of biochemical and molecular toxicology, , Volume: 34, Issue:7, 2020

In vitro and in vivo evaluation of inhibition activity of lotus (Nelumbo nucifera Gaertn.) leaves against ultraviolet B-induced phototoxicity.
Journal of photochemistry and photobiology. B, Biology, , Apr-05, Volume: 121, 2013

Ascorbate enhances the toxicity of the photodynamic action of Verteporfin in HL-60 cells.
Free radical biology & medicine, , May-01, Volume: 40, Issue:9, 2006

Topical methimazole as a new treatment for postinflammatory hyperpigmentation: report of the first case.
Dermatology (Basel, Switzerland), , Volume: 211, Issue:4, 2005

Peroxidase-mediated mechanisms are involved in the melanocytotoxic and melanogenesis-inhibiting effects of chemical agents.
Dermatology (Basel, Switzerland), , Volume: 205, Issue:4, 2002

A case of myeloperoxidase-antineutrophil cytoplasmic antibody and anticardiolipin antibody-positive pyogenic arthritis, pyoderma gangrenosum, acne and hidradenitis suppurativa (PAPASH) syndrome with colitis.
Modern rheumatology case reports, , Volume: 5, Issue:2, 2021

Identifying key components and therapeutic targets of the immune system in hidradenitis suppurativa with an emphasis on neutrophils.
The British journal of dermatology, , Volume: 184, Issue:6, 2021

A case of myeloperoxidase-antineutrophil cytoplasmic antibody and anticardiolipin antibody-positive pyogenic arthritis, pyoderma gangrenosum, acne and hidradenitis suppurativa (PAPASH) syndrome with colitis.
Modern rheumatology case reports, , Volume: 5, Issue:2, 2021

Role of inflammatory cells, cytokines and matrix metalloproteinases in neutrophil-mediated skin diseases.
Clinical and experimental immunology, , Volume: 162, Issue:1, 2010

Inflammatory cells, cytokines and matrix metalloproteinases in amicrobial pustulosis of the folds and other neutrophilic dermatoses.
International journal of immunopathology and pharmacology, , Volume: 24, Issue:2

The Impact of Myeloperoxidase in the Rupturing of Cerebral Aneurysms.
World neurosurgery, , Volume: 147, 2021

The role of oxidative stress as a risk factor for rupture of posterior inferior cerebellar artery aneurysms.
Molecular biology reports, , Volume: 45, Issue:6, 2018

Myeloperoxidase is increased in human cerebral aneurysms and increases formation and rupture of cerebral aneurysms in mice.
Stroke, , Volume: 46, Issue:6, 2015

Myeloperoxidase in human intracranial aneurysms: preliminary evidence.
Stroke, , Volume: 45, Issue:5, 2014

Role of TNF-alpha in myocardial dysfunction after hemorrhagic shock and lower-torso ischemia.
American journal of physiology. Heart and circulatory physiology, , Volume: 278, Issue:3, 2000

The Role of Inflammation and Myeloperoxidase-Related Oxidative Stress in the Pathogenesis of Genetically Triggered Thoracic Aortic Aneurysms.
International journal of molecular sciences, , Oct-16, Volume: 21, Issue:20, 2020

The inflammatory response to stent grafting of the thoracic aorta.
International angiology : a journal of the International Union of Angiology, , Volume: 26, Issue:3, 2007

Mechanism of complement activation and its role in the inflammatory response after thoracoabdominal aortic aneurysm repair.
Circulation, , Aug-19, Volume: 108, Issue:7, 2003

New insights into the molecular pathology of radiation-induced pneumopathy.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, , Volume: 101, Issue:1, 2011

Mimicking the mimicker: Necrotizing sarcoid granulomatosis.
The American journal of the medical sciences, , Volume: 364, Issue:4, 2022

Use of discriminant analysis in assessing pulmonary function worsening in patients with sarcoidosis by a panel of inflammatory biomarkers.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 62, Issue:3, 2013

Potential etiologic agents in sarcoidosis.
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The effect of nebivolol treatment on oxidative stress and antioxidant status in patients with cardiac syndrome-X.
Coronary artery disease, , Volume: 20, Issue:3, 2009

Scleroderma with type III glomerulonephritis and MPO-ANCA antibodies in the serum.
Journal of the European Academy of Dermatology and Venereology : JEADV, , Volume: 19, Issue:5, 2005

[Anti-neutrophil cytoplasmic autoantibody-associated rapid progressive glomerulonephritis complicated with both limited and diffuse scleroderma].
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, , Volume: 25, Issue:6, 2002

A case of CREST syndrome and myeloperoxidase-specific anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis.
Clinical nephrology, , Volume: 53, Issue:4, 2000

Expression of lacto-N-fucopentaose III (CD15)- and sialyl-Lewis X-bearing molecules and their functional properties in eosinophils from patients with the idiopathic hypereosinophilic syndrome.
Immunology, , Volume: 83, Issue:2, 1994

Releasability of human hypereosinophilic eosinophils is related to the density of the cells.
British journal of haematology, , Volume: 86, Issue:1, 1994

Induction of myeloperoxidase and nitrotyrosine formation in a human eosinophilic leukemia cell line, EoL-1.
Cell biochemistry and function, , Volume: 22, Issue:2

Protective effects of NHE1 inhibition with sabiporide in an experimental model of asphyxia-induced cardiac arrest in piglets.
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Controlled intermittent asystole cardiac therapy induced by pharmacologically potentiated vagus nerve stimulation in normal and hibernating myocardium.
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Endothelial stunning and myocyte recovery after reperfusion of jeopardized muscle: a role of L-arginine blood cardioplegia.
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Cumulative effects of bone and soft tissue injury on systemic inflammation: a pilot study.
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The role of fracture-associated soft tissue injury in the induction of systemic inflammation and remote organ dysfunction after bilateral femur fracture.
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Chronic prostatitis/chronic pelvic pain pyndrome): seminal markers of inflammation.
World journal of urology, , Volume: 21, Issue:2, 2003

Systemic cholesterol embolization syndrome associated with myeloperoxidase-anti-neutrophil cytoplasmic antibody.
Internal medicine (Tokyo, Japan), , Volume: 45, Issue:8, 2006

An unusual case of ANCA positive disease.
Annals of the rheumatic diseases, , Volume: 62, Issue:8, 2003

Pauci-immune extracapillary glomerulonephritis and atheromatous embolization.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 40, Issue:4, 2002

Cholesterol embolism associated with MPO-ANCA.
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[The functional properties and oxidative modification of plasma and neutrophil proteins in community-acquired pneumonia].
Klinicheskaia laboratornaia diagnostika, , Issue:3, 2010

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Neutrophil infiltration and activation in bronchiolitic airways are independent of viral etiology.
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Respiratory syncytical virus-induced chemokine expression in the lower airways: eosinophil recruitment and degranulation.
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Immunophenotypes in adult acute lymphocytic leukemia. Role of flow cytometry in diagnosis and monitoring of disease.
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Influenza virus infection causes neutrophil dysfunction through reduced G-CSF production and an increased risk of secondary bacteria infection in the lung.
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Serum levels of the soluble haemoglobin scavenger receptor CD163 in MPO-ANCA-associated renal vasculitis.
Scandinavian journal of rheumatology, , Volume: 45, Issue:5, 2016

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Efficacy of AiiM, an N-acylhomoserine lactonase, against Pseudomonas aeruginosa in a mouse model of acute pneumonia.
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Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice.
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Secretory immunoglobulin A abrogates inflammatory responses and improves mortality after pseudomonas pneumonia.
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Identification of high- and low-virulent strains of Chlamydia pneumoniae by their characterization in a mouse pneumonia model.
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Staphylococcus aureus infection after splenectomy and splenic autotransplantation in BALB/c mice.
Clinical and experimental immunology, , Volume: 154, Issue:2, 2008

Anti-inflammatory effect of thalidomide alone or in combination with augmentin in Klebsiella pneumoniae B5055 induced acute lung infection in BALB/c mice.
European journal of pharmacology, , Sep-11, Volume: 592, Issue:1-3, 2008

Chlamydia pneumoniae infection and MPO-ANCA-associated glomerulonephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 22, Issue:3, 2007

Anti-inflammatory effects of inhaled nitric oxide are optimized at lower oxygen concentration in experimental Klebsiella pneumoniae pneumonia.
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The acute-phase response and serum amyloid A inhibit the inflammatory response to Acinetobacter baumannii Pneumonia.
The Journal of infectious diseases, , Jan-15, Volume: 193, Issue:2, 2006

Effects of oral administration of tilmicosin on pulmonary inflammation in piglets experimentally infected with Actinobacillus pleuropneumoniae.
American journal of veterinary research, , Volume: 66, Issue:1, 2005

Effect of ventilation strategy and surfactant on inflammation in experimental pneumonia.
The European respiratory journal, , Volume: 26, Issue:1, 2005

The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation.
American journal of respiratory and critical care medicine, , Apr-15, Volume: 171, Issue:8, 2005

Effects of systemic and local CXC chemokine administration on the ethanol-induced suppression of pulmonary neutrophil recruitment.
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Pseudomonas pneumonia-mediated sepsis induces expression of pancreatitis-associated protein-I in rat pancreas.
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American journal of respiratory cell and molecular biology, , Volume: 29, Issue:4, 2003

A novel model of pneumonia from intraperitoneal injection of bacteria.
American journal of surgery, , Volume: 186, Issue:5, 2003

Pleural-fluid myeloperoxidase in complicated and noncomplicated parapneumonic pleural effusions.
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Effect of alcohol consumption on host release of interleukin-17 during pulmonary infection with Klebsiella pneumoniae.
Alcoholism, clinical and experimental research, , Volume: 25, Issue:6, 2001

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Alveolar macrophages that phagocytose apoptotic neutrophils produce hepatocyte growth factor during bacterial pneumonia in mice.
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Mercaptoethylguanidine inhibits the inflammatory response in a murine model of chronic infection with Pseudomonas aeruginosa.
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Microvascular perfusion deficits are not a prerequisite for mucosal injury in septic rats.
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Neutralization of macrophage inflammatory protein-2 attenuates neutrophil recruitment and bacterial clearance in murine Klebsiella pneumonia.
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Is there a relationship between myeloperoxidase activity and conductive hearing loss in chronic otitis media complicated by cholesteatoma?
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Prognostic value and echocardiographic determinants of plasma myeloperoxidase levels in chronic heart failure.
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Low coronary driving pressure is associated with subendocardial remodelling and left ventricular dysfunction in aortocaval fistula.
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Comparison of 8 biomarkers for prediction of right ventricular hypokinesis 6 months after submassive pulmonary embolism.
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Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice.
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Myeloperoxidase Attenuates Pathogen Clearance during Plasmodium yoelii Nonlethal Infection.
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Antimyeloperoxidase antibody is a biomarker for progression of diabetic retinopathy.
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Generation of neutrophil extracellular traps in patients with acute liver failure is associated with poor outcome.
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Shenmai Injection Upregulates Heme Oxygenase-1 to Confer Protection Against Severe Acute Pancreatitis.
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Impact of Isolated Burns on Major Organs: A Large Animal Model Characterized.
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Lipopolysaccharide and hemorrhagic shock cause systemic inflammation by different mechanisms.
The journal of trauma and acute care surgery, , Volume: 74, Issue:1, 2013

Characterization of the LPS-induced inflammation of the adrenal gland in mice.
Molecular and cellular endocrinology, , May-22, Volume: 371, Issue:1-2, 2013

Damage control resuscitation decreases systemic inflammation after hemorrhage.
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Diagnostic value of the neutrophil myeloperoxidase index in horses with systemic inflammation.
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Protective effect of transplanted bone marrow-derived mesenchymal stem cells on pancreatitis-associated lung injury in rats.
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Disparate roles of marrow- and parenchymal cell-derived TLR4 signaling in murine LPS-induced systemic inflammation.
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Effect of N-acetylcysteine treatment on oxidative stress and inflammation after severe burn.
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Characterization of pulmonary and systemic inflammatory responses produced by lung re-expansion after one-lung ventilation.
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Cytokines induced neutrophil extracellular traps formation: implication for the inflammatory disease condition.
PloS one, , Volume: 7, Issue:10, 2012

Delta neutrophil index: a promising diagnostic and prognostic marker for sepsis.
Shock (Augusta, Ga.), , Volume: 37, Issue:3, 2012

Comparison of oxidative stress & leukocyte activation in patients with severe sepsis & burn injury.
The Indian journal of medical research, , Volume: 134, 2011

Standardization of a method of prolonged thoracic surgery and mechanical ventilation in rats to evaluate local and systemic inflammation.
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Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis.
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CO2 abdominal insufflation decreases local and systemic inflammatory response in experimental acute pancreatitis.
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Aggravation of acute pancreatitis by heparan sulfate in mice.
Scandinavian journal of gastroenterology, , Volume: 44, Issue:5, 2009

Role of myeloperoxidase as predictor of systemic inflammatory response syndrome in patients with ST-segment elevation myocardial infarction after primary percutaneous coronary intervention.
The American journal of cardiology, , Sep-01, Volume: 104, Issue:5, 2009

Neutrophil-derived circulating free DNA (cf-DNA/NETs): a potential prognostic marker for posttraumatic development of inflammatory second hit and sepsis.
Shock (Augusta, Ga.), , Volume: 30, Issue:4, 2008

Suppression of endotoxin-induced inflammation by taxol.
The European respiratory journal, , Volume: 30, Issue:3, 2007

Natural anticoagulants limit lipopolysaccharide-induced pulmonary coagulation but not inflammation.
The European respiratory journal, , Volume: 30, Issue:3, 2007

Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure.
Critical care medicine, , Volume: 35, Issue:1, 2007

Inhaled nitric oxide attenuates hyperoxic and inflammatory injury without alteration of phosphatidylcholine synthesis in rat lungs.
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Keratinocyte-derived chemokine plays a critical role in the induction of systemic inflammation and tissue damage after trauma-hemorrhage.
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Laboratory investigation: effects of propofol on the systemic inflammatory response during aortic surgery.
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[The influence of leukocyte depletion filter-LD-1 on leukocytes, IL-6, MPO and the pathologic changes of myocardic tissues during cardiopulmonary bypass].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, , Volume: 36, Issue:3, 2005

Exogenous nitric oxide modulates the systemic inflammatory response and improves kidney function after risk-situation abdominal aortic surgery.
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Inhibition of enteral enzymes by enteroclysis with nafamostat mesilate reduces neutrophil activation and transfusion requirements after hemorrhagic shock.
The Journal of trauma, , Volume: 56, Issue:3, 2004

The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model.
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Differential effects of macrophage inflammatory chemokine-2 and keratinocyte-derived chemokine on hemorrhage-induced neutrophil priming for lung inflammation: assessment by adoptive cells transfer in mice.
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Inhibition of matrix metalloproteinases reduces local and distant organ injury following experimental acute pancreatitis.
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Protective effects of apocynin on "two-hit" injury induced by hemorrhagic shock and lipopolysaccharide.
Acta pharmacologica Sinica, , Volume: 23, Issue:11, 2002

Effects of inhaled nitric oxide in a mouse model of sepsis-induced acute lung injury.
Critical care medicine, , Volume: 30, Issue:4, 2002

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Recombinant bactericidal/permeability-increasing protein attenuates the systemic inflammatory response syndrome in lower limb ischemia-reperfusion injury.
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Mild endotoxaemia and the inflammatory response induced by a marathon race.
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Tobacco differentially affects the clinical-biological phenotypes of ANCA-associated vasculitides.
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Organ specific apoptosis following polymicrobial intraperitoneal infection.
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Association of Myeloperoxidase Gene Polymorphism With Iron Deficiency Anemia in Turkish Children.
Journal of pediatric hematology/oncology, , Oct-01, Volume: 43, Issue:7, 2021

Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation.
Haematologica, , Volume: 101, Issue:11, 2016

Chronic pulmonary bleeding as the first sign of microscopic polyangiitis associated with autoimmune thyroiditis.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, , Volume: 31, Issue:4, 2011

Inflammation markers in nasal lavage, and nasal symptoms in relation to relocation to a newly painted building: a longitudinal study.
International archives of occupational and environmental health, , Volume: 72, Issue:8, 1999

Nasal lavage biomarkers: effects of water damage and microbial growth in an office building.
Archives of environmental health, , Volume: 56, Issue:1

Neutrophil ablation with anti-serum does not protect against phase 2 ventricular arrhythmias in anaesthetised rats with myocardial infarction.
Cardiovascular research, , Mar-01, Volume: 73, Issue:4, 2007

Possible role of cardiac mast cells in norepinephrine-induced myocardial preconditioning.
Methods and findings in experimental and clinical pharmacology, , Volume: 21, Issue:4, 1999

Dietary Moringa oleifera leaf powder improves jejunal permeability and digestive function by modulating the microbiota composition and mucosal immunity in heat stressed rabbits.
Environmental science and pollution research international, , Volume: 29, Issue:53, 2022

Effect of tropical thermal stress on peri-implantation immune responses in cows.
Theriogenology, , Jul-01, Volume: 114, 2018

Carbon liberated from CO-releasing molecules attenuates leukocyte infiltration in the small intestine of thermally injured mice.
World journal of gastroenterology, , Dec-14, Volume: 13, Issue:46, 2007

Impact of elevated ambient temperatures on the acute immune response to intensive endurance exercise.
European journal of applied physiology, , Volume: 89, Issue:3-4, 2003

Oxytocin maintains lung histological and functional integrity to confer protection in heat stroke.
Scientific reports, , 12-05, Volume: 9, Issue:1, 2019

Thrombomodulin improved liver injury, coagulopathy, and mortality in an experimental heatstroke model in mice.
Anesthesia and analgesia, , Volume: 118, Issue:5, 2014

Inhibition of acute lung inflammation and injury is a target of brain cooling after heatstroke injury.
The Journal of trauma, , Volume: 69, Issue:4, 2010

Heat shock response decreases endotoxin-induced acute lung injury in rats.
Respirology (Carlton, Vic.), , Volume: 4, Issue:4, 1999

Differential clinicopathologic features of EGPA-associated neuropathy with and without ANCA.
Neurology, , 04-21, Volume: 94, Issue:16, 2020

Recognizing Central Nervous System Involvement as a Progressive Feature of Microscopic Polyangiitis: A Diagnostic Dilemma.
The American journal of medicine, , Volume: 132, Issue:9, 2019

Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis (AAV) Restricted to the Limbs.
Internal medicine (Tokyo, Japan), , May-01, Volume: 57, Issue:9, 2018

Arteritic anterior ischemic optic neuropathy with positive myeloperoxidase antineutrophil cytoplasmic antibody.
Japanese journal of ophthalmology, , Volume: 54, Issue:4, 2010

High- density lipoprotein function is abnormal in idiopathic inflammatory myopathies.
Rheumatology (Oxford, England), , 11-01, Volume: 59, Issue:11, 2020

[Clinicopathologic features of granulocytic sarcoma: a study of 38 cases].
Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 39, Issue:3, 2010

A patient with intravascular lymphoma presenting with cerebral infarction and a high serum MPO-ANCA level.
Modern rheumatology, , Volume: 21, Issue:2, 2011

Myeloperoxidase-positive intravascular large B-cell lymphoma.
Archives of pathology & laboratory medicine, , Volume: 125, Issue:7, 2001

Immunophenotypic analysis of myeloperoxidase-negative leukemia cutis and blastic plasmacytoid dendritic cell neoplasm.
American journal of clinical pathology, , Volume: 137, Issue:3, 2012

Fish oil before cardiac surgery: neutrophil activation is unaffected but myocardial damage is moderated.
Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 72, Issue:4, 2005

Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor).
Journal of innate immunity, , Volume: 10, Issue:1, 2018

Flagellin administration protects respiratory tract from Burkholderia cepacia infection.
Journal of microbiology and biotechnology, , Volume: 22, Issue:7, 2012

Comparative analysis of extracellular enzymes and virulence exhibited by Burkholderia pseudomallei from different sources.
Microbial pathogenesis, , Volume: 47, Issue:3, 2009

In vitro resistance of Burkholderia cepacia complex isolates to reactive oxygen species in relation to catalase and superoxide dismutase production.
Microbiology (Reading, England), , Volume: 147, Issue:Pt 1, 2001

Clinicopathological and immunohistochemical analysis of 19 cases of oral eosinophilic ulcers.
Oral surgery, oral medicine, oral pathology and oral radiology, , Volume: 115, Issue:4, 2013

Effects of the tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters.
European journal of oral sciences, , Volume: 113, Issue:3, 2005

Pathologic diagnosis of acute lymphocytic leukemia.
Hematology/oncology clinics of North America, , Volume: 14, Issue:6, 2000

ICAM-1-dependent and ICAM-1-independent neutrophil lung infiltration by porcine reproductive and respiratory syndrome virus infection.
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Neutrophil extracellular trap formation and circulating nucleosomes in patients with chronic myeloproliferative neoplasms.
Scientific reports, , 12-13, Volume: 6, 2016

Mocetinostat (MGCD0103): a review of an isotype-specific histone deacetylase inhibitor.
Expert opinion on investigational drugs, , Volume: 20, Issue:6, 2011

Clinical studies of histone deacetylase inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research, , Jun-15, Volume: 15, Issue:12, 2009

Serglycin proteoglycan in hematologic malignancies: a marker of acute myeloid leukemia.
Leukemia, , Volume: 21, Issue:12, 2007

Antibodies and immunohistochemical evaluation for the diagnosis of hematological malignancies: an overview.
Methods in molecular biology (Clifton, N.J.), , Volume: 378, 2007

Peroxidase activity and nuclear density analysis (PANDA) in the diagnosis of haematological malignancy.
British journal of biomedical science, , Volume: 62, Issue:3, 2005

[Immunocytochemistry techniques for the diagnosis of hematologic neoplasms].
Medicina, , Volume: 59, Issue:1, 1999

Intestinal Barrier Disruption in Ileal Pouchitis After Ileal Pouch-Anal Anastomosis in a Rat Model.
Inflammatory bowel diseases, , Volume: 23, Issue:6, 2017

Stasis predisposes ileal pouch inflammation in a rat model of ileal pouch-anal anastomosis.
The Journal of surgical research, , Volume: 164, Issue:1, 2010

Partially hydrolyzed guar gum attenuates the severity of pouchitis in a rat model of ileal J pouch-anal anastomosis.
Digestive diseases and sciences, , Volume: 54, Issue:3, 2009

Role of stasis and oxidative stress in ileal pouch inflammation.
The Journal of surgical research, , May-01, Volume: 90, Issue:1, 2000

Biliary lactoferrin concentrations are increased in active inflammatory bowel disease: a factor in the pathogenesis of primary sclerosing cholangitis?
Clinical science (London, England : 1979), , Volume: 95, Issue:5, 1998

Overexpression of ZNF342 by juxtaposition with MPO promoter/enhancer in the novel translocation t(17;19)(q23;q13.32) in pediatric acute myeloid leukemia and analysis of ZNF342 expression in leukemia.
Genes, chromosomes & cancer, , Volume: 48, Issue:6, 2009

Preventive role of gallic acid on alcohol dependent and cysteine protease-mediated pancreas injury.
Molecular biology reports, , Volume: 39, Issue:12, 2012

VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis.
The Journal of clinical investigation, , Volume: 118, Issue:7, 2008

Alcohol-induced protein kinase Calpha phosphorylation of Munc18c in carbachol-stimulated acini causes basolateral exocytosis.
Gastroenterology, , Volume: 132, Issue:4, 2007

Immune-compromised state in the rat pancreas after chronic alcohol exposure: the role of peroxisome proliferator-activated receptor gamma.
The Journal of pathology, , Volume: 213, Issue:4, 2007

Oxygen radical production precedes alcohol-induced acute pancreatitis in rats.
Pancreas, , Volume: 26, Issue:4, 2003

Cigarette smoke enhances ethanol-induced pancreatic injury.
Pancreas, , Volume: 21, Issue:3, 2000

[IgG4- and MPO-ANCA-associated hypertrophic pachymeningitis].
Revista de neurologia, , Nov-16, Volume: 61, Issue:10, 2015

Histone deacetylase inhibitors trichostatin A and suberoylanilide hydroxamic acid attenuate ventilator-induced lung injury.
Die Pharmazie, , Volume: 69, Issue:1, 2014

Circulating IL-6 mediates lung injury via CXCL1 production after acute kidney injury in mice.
American journal of physiology. Renal physiology, , Sep-15, Volume: 303, Issue:6, 2012

Splenectomy exacerbates lung injury after ischemic acute kidney injury in mice.
American journal of physiology. Renal physiology, , Volume: 301, Issue:4, 2011

Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity.
Biochemical and biophysical research communications, , Dec-19, Volume: 377, Issue:3, 2008

Early treatment with hydroxyethyl starch 130/0.4 causes greater inhibition of pulmonary capillary leakage and inflammatory response than treatment instituted later in sepsis induced by cecal ligation and puncture in rats.
Annals of clinical and laboratory science, ,Winter, Volume: 37, Issue:1, 2007

Suppression of endotoxin-induced inflammation by taxol.
The European respiratory journal, , Volume: 30, Issue:3, 2007

Constitutive expression of IL-2Rbeta chain and its effects on IL-2-induced vascular leak syndrome.
Cytokine, , Dec-21, Volume: 32, Issue:6, 2005

Effect of femoral fracture and intramedullary fixation on lung capillary leak.
The Journal of trauma, , Volume: 46, Issue:4, 1999

Expression of oxidative stress in metastatic retinoblastoma- a comparative study.
Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH, , Volume: 4, Issue:2

Current Symptomatic and Disease-Modifying Treatments in Multiple System Atrophy.
International journal of molecular sciences, , Apr-16, Volume: 21, Issue:8, 2020

Population Pharmacokinetic Modeling With Enterohepatic Circulation for AZD3241 in Healthy Subjects and Patients With Multiple System Atrophy.
Journal of clinical pharmacology, , Volume: 58, Issue:11, 2018

Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications.
Neurotoxicity research, , Volume: 28, Issue:3, 2015

Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model.
Neurotoxicity research, , Volume: 21, Issue:4, 2012

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

The lipid paradox in neuroprogressive disorders: Causes and consequences.
Neuroscience and biobehavioral reviews, , Volume: 128, 2021

The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease.
Antioxidants & redox signaling, , 05-01, Volume: 32, Issue:13, 2020

Loss-of-Function Myeloperoxidase Mutations Are Associated with Increased Neutrophil Counts and Pustular Skin Disease.
American journal of human genetics, , 09-03, Volume: 107, Issue:3, 2020

Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype.
International journal of molecular sciences, , Aug-22, Volume: 21, Issue:17, 2020

Redox and Peroxidase Activities of the Hemoglobin Superfamily: Relevance to Health and Disease.
Antioxidants & redox signaling, , 05-10, Volume: 26, Issue:14, 2017

Circulating Advanced Oxidation Protein Products as Oxidative Stress Biomarkers and Progression Mediators in Pathological Conditions Related to Inflammation and Immune Dysregulation.
Current medicinal chemistry, , Volume: 23, Issue:34, 2016

Myeloperoxidase: Bridging the gap in neurodegeneration.
Neuroscience and biobehavioral reviews, , Volume: 68, 2016

Inhibition of myeloperoxidase-mediated oxidative damage by nitrite in SH-SY5Y cells: Relevance to neuroprotection in neurodegenerative diseases.
European journal of pharmacology, , Jun-05, Volume: 780, 2016

Myeloperoxidase as a Target for the Treatment of Inflammatory Syndromes: Mechanisms and Structure Activity Relationships of Inhibitors.
Current medicinal chemistry, , Volume: 23, Issue:35, 2016

Heme-coordinated histidine residues form non-specific functional "ferritin-heme" peroxidase system: Possible and partial mechanistic relevance to oxidative stress-mediated pathology in neurodegenerative diseases.
International journal of biological macromolecules, , Volume: 91, 2016

G-quadruplex structures formed by expanded hexanucleotide repeat RNA and DNA from the neurodegenerative disease-linked C9orf72 gene efficiently sequester and activate heme.
PloS one, , Volume: 9, Issue:9, 2014

Heme, as a chaperone, binds to amyloid fibrils and forms peroxidase in vitro: possible evidence on critical role of non-specific peroxidase activity in neurodegenerative disease onset/progression using the alpha-crystallin-based experimental system.
Archives of biochemistry and biophysics, , Feb-15, Volume: 494, Issue:2, 2010

Microglia and myeloperoxidase: a deadly partnership in neurodegenerative disease.
Free radical biology & medicine, , Sep-01, Volume: 45, Issue:5, 2008

Dietary chelators as antioxidant enzyme mimetics: implications for dietary intervention in neurodegenerative diseases.
Behavioural pharmacology, , Volume: 17, Issue:5-6, 2006

2020 international consensus on ANCA testing beyond systemic vasculitis.
Autoimmunity reviews, , Volume: 19, Issue:9, 2020

Oxidative stress and antioxidant status in patients with autoimmune liver diseases.
Redox report : communications in free radical research, , Volume: 20, Issue:1, 2015

Detection of anti-lactoferrin antibodies and anti-myeloperoxidase antibodies in autoimmune hepatitis: a retrospective study.
Journal of immunoassay & immunochemistry, , Volume: 35, Issue:4, 2014

Bioactivation of minocycline to reactive intermediates by myeloperoxidase, horseradish peroxidase, and hepatic microsomes: implications for minocycline-induced lupus and hepatitis.
Drug metabolism and disposition: the biological fate of chemicals, , Volume: 37, Issue:9, 2009

SLE and rapidly progressive glomerulonephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 45, Issue:5, 2005

Graves' disease accompanied by anti-myeloperoxidase antibody-related nephropathy and autoimmune hepatitis.
Internal medicine (Tokyo, Japan), , Volume: 43, Issue:6, 2004

[A case of ANCA positive idiopathic crescentic glomerulonephritis initiated with fever and liver dysfunction].
Rinsho byori. The Japanese journal of clinical pathology, , Volume: 48, Issue:6, 2000

Coexistent minocycline-induced systemic lupus erythematosus and autoimmune hepatitis.
Seminars in arthritis and rheumatism, , Volume: 28, Issue:3, 1998

Relationship between disease severity and myeloperoxidase in chronic viral hepatitis: a prospective study.
Biomarkers in medicine, , Volume: 17, Issue:6, 2023

Plasma myeloperoxidase activity and apolipoprotein A-1 expression in chronic hepatitis B patients.
Archives of Iranian medicine, , Volume: 14, Issue:4, 2011

Levels of malondialdehyde, myeloperoxidase and nitrotyrosine in patients with chronic viral hepatitis B and C.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, , Volume: 21, Issue:1

Myeloperoxidase gene polymorphism predicts fibrosis severity in women with hepatitis C.
Human immunology, , Volume: 75, Issue:8, 2014

A variant in myeloperoxidase promoter hastens the emergence of hepatocellular carcinoma in patients with HCV-related cirrhosis.
Journal of hepatology, , Volume: 56, Issue:2, 2012

B-cell-activating factor affects the occurrence of thyroid autoimmunity in chronic hepatitis C patients treated with interferon alpha.
Clinical & developmental immunology, , Volume: 2012, 2012

Plasma myeloperoxidase levels correlate with hepatocellular carcinoma in chronic hepatitis C.
Human immunology, , Volume: 73, Issue:11, 2012

Oxidant and antioxidant of arylesterase and paraoxonase as biomarkers in patients with hepatitis C virus.
Clinical biochemistry, , Volume: 42, Issue:13-14, 2009

[Effects of supplementation with the antioxidant flavonoid, silymarin, in chronic hepatitis C patients treated with peg-interferon + ribavirin. A placebo-controlled double blind study].
Orvosi hetilap, , Jan-11, Volume: 150, Issue:2, 2009

[Case of ANCA associated vasculitis induced by interferon therapy for HCV infection].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, , Volume: 105, Issue:12, 2008

[A case of MPO-ANCA-related microscopic polyangiitis with mixed cryoglobulinemia].
Nihon Jinzo Gakkai shi, , Volume: 48, Issue:4, 2006

A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection.
Genes and immunity, , Volume: 3, Issue:6, 2002

[A case of hepatitis C virus-associated glomerulonephropathy presenting with MPO-ANCA-positive rapidly progressive glomerulonephritis].
Nihon Jinzo Gakkai shi, , Volume: 42, Issue:4, 2000

Interferon/antioxidant combination therapy for chronic hepatitis C--a controlled pilot trial.
Antiviral research, , Volume: 43, Issue:2, 1999

Levels of malondialdehyde, myeloperoxidase and nitrotyrosine in patients with chronic viral hepatitis B and C.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, , Volume: 21, Issue:1

Double-Stranded DNA and NETs Components in Relation to Clinical Outcome After ST-Elevation Myocardial Infarction.
Scientific reports, , 03-19, Volume: 10, Issue:1, 2020

Microscopic polyangiitis: A little-known new risk factor of venous thrombosis.
Journal des maladies vasculaires, , Volume: 40, Issue:6, 2015

Myeloperoxidase and plaque vulnerability.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 24, Issue:7, 2004

Anti-glomerular Basement Membrane Disease Concomitant with MPO-ANCA Positivity Concurrent with High Serum Levels of Interleukin-26 Following Coronavirus Disease 2019 Vaccination.
Internal medicine (Tokyo, Japan), , Apr-01, Volume: 62, Issue:7, 2023

Clinical features and prognosis of MPO-ANCA and anti-GBM double-seropositive patients.
Frontiers in immunology, , Volume: 13, 2022

Inhibitory Anti-Peroxidasin Antibodies in Pulmonary-Renal Syndromes.
Journal of the American Society of Nephrology : JASN, , Volume: 29, Issue:11, 2018

Peroxidasin-a Novel Autoantigen in Anti-GBM Disease?
Journal of the American Society of Nephrology : JASN, , Volume: 29, Issue:11, 2018

Autoantibodies against Linear Epitopes of Myeloperoxidase in Anti-Glomerular Basement Membrane Disease.
Clinical journal of the American Society of Nephrology : CJASN, , Apr-07, Volume: 11, Issue:4, 2016

Asymptomatic autoantibodies associate with future anti-glomerular basement membrane disease.
Journal of the American Society of Nephrology : JASN, , Volume: 22, Issue:10, 2011

Autoantibodies: what's in their teeth?
Journal of the American Society of Nephrology : JASN, , Volume: 22, Issue:10, 2011

Anti-glomerular basement membrane (anti-GBM) disease accompanied by vasculitis that was not positive for antineutrophil cytoplasmic antibodies to myeloperoxidase and proteinase 3: a report of two cases and the incidence of anti-GBM disease at one institut
Clinical and experimental nephrology, , Volume: 15, Issue:4, 2011

[79-year-old patient with pulmorenal syndrome].
Deutsche medizinische Wochenschrift (1946), , Volume: 135, Issue:40, 2010

Anti-GBM antibodies co-exist with MPO-ANCA in a 4-year-old girl with acute renal failure.
Pediatric nephrology (Berlin, Germany), , Volume: 24, Issue:1, 2009

Clinical outcome of patients with coexistent antineutrophil cytoplasmic antibodies and antibodies against glomerular basement membrane.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, , Volume: 13, Issue:4, 2009

Autoimmunity in kidney diseases.
Scandinavian journal of clinical and laboratory investigation. Supplementum, , Volume: 241, 2008

Role of antineutrophil cytoplasmic antibodies and glomerular basement membrane antibodies in the diagnosis and monitoring of systemic vasculitides.
Annals of clinical biochemistry, , Volume: 44, Issue:Pt 5, 2007

The role ANCA and anti-GBM antibodies in pulmonary-renal syndrome due to Wegener's granulomatosis.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, , Volume: 58 Suppl 5, Issue:Pt 2, 2007

Use of immunofluorescence and confocal laser scanning microscopy in identifying rare cases of anti-neutrophil cytoplasmic antibodies (ANCA) showing dual specificities to myeloperoxidase and proteinase3.
Journal of fluorescence, , Volume: 14, Issue:4, 2004

[Pulmonary-renal syndrome and Goodpasture's syndrome].
Nihon rinsho. Japanese journal of clinical medicine, , Volume: 62 Suppl 5, 2004

Successful renal transplantation in a child with ANCA-associated microscopic polyangiitis.
Pediatric nephrology (Berlin, Germany), , Volume: 18, Issue:7, 2003

Simultaneous occurrence of diabetic glomerulosclerosis, IgA nephropathy, crescentic glomerulonephritis, and myeloperoxidase-antineutrophil cytoplasmic antibody seropositivity in a Chinese patient.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 40, Issue:4, 2002

[Lung involvement in rapidly progressive glomerulonephritis].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, , Volume: 39, Issue:2, 2001

Sequential development of pulmonary hemorrhage with MPO-ANCA complicating anti-glomerular basement membrane antibody-mediated glomerulonephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 35, Issue:5, 2000

[An experience of treatment of double positive myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCA) and anti-glomerular basement membrane antibodies in Goodpasture's syndrome onset of crescentic glomerulonephritis].
Nihon Jinzo Gakkai shi, , Volume: 40, Issue:8, 1998

Expression of iNOS, eNOS, and peroxynitrite-modified proteins in experimental anti-myeloperoxidase associated crescentic glomerulonephritis.
Kidney international, , Volume: 53, Issue:2, 1998

Goodpasture's syndrome associated with primary biliary cirrhosis.
Internal medicine (Tokyo, Japan), , Volume: 37, Issue:7, 1998

Myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis with membranous nephropathy in remission.
Internal medicine (Tokyo, Japan), , Volume: 36, Issue:11, 1997

[A case of Goodpasture's syndrome with myeloperoxidase specific anti-neutrophil cytoplasmic autoantibody (MPO-ANCA) during chronic interstitial pneumonia].
Nihon Kyobu Shikkan Gakkai zasshi, , Volume: 35, Issue:12, 1997

Rapid screening assay for anti-GBM antibody and ANCAs; an important tool for the differential diagnosis of pulmonary renal syndromes.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 12, Issue:9, 1997

Goodpasture-like syndrome associated with anti-myeloperoxidase antibodies following penicillamine treatment.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 10, Issue:10, 1995

Circulating autoantibodies as serological markers in the differential diagnosis of pulmonary renal syndrome.
Journal of internal medicine, , Volume: 238, Issue:2, 1995

Use of antineutrophil cytoplasmic autoantibodies in diagnosing vasculitis in a Chinese patient population.
American journal of nephrology, , Volume: 14, Issue:2, 1994

Characterization of a non-Goodpasture autoantibody to type IV collagen.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 8, Issue:11, 1993

Antineutrophil-cytoplasmic antibodies and antiglomerular basement membrane antibodies in Goodpasture's syndrome and in Wegener's granulomatosis.
Journal of the American Society of Nephrology : JASN, , Volume: 2, Issue:7, 1992

A case of Goodpasture's syndrome associated with anti-myeloperoxidase antibodies.
Internal medicine (Tokyo, Japan), , Volume: 31, Issue:2, 1992

Circulating autoantibodies in patients with extracapillary glomerulonephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 6, Issue:6, 1991

[A case of Goodpasture's syndrome. Myeloperoxidase antibodies as a valuable serological marker in vasculitis].
Lakartidningen, , Oct-17, Volume: 87, Issue:42, 1990

Assessment of a multi-assay biological diagnostic test for mood disorders in a Japanese population.
Neuroscience letters, , Jan-26, Volume: 612, 2016

The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future.
BMC psychiatry, , Aug-18, Volume: 4, 2004

Investigation of DNA damage, oxidative stress, and inflammation in synthetic cannabinoid users.
Human & experimental toxicology, , Volume: 39, Issue:11, 2020

Epistasis of oxidative stress-related enzyme genes on modulating the risks in oral cavity cancer.
Clinica chimica acta; international journal of clinical chemistry, , Nov-11, Volume: 411, Issue:21-22, 2010

Effects of Stealth adulterant on immunoassay testing for drugs of abuse.
Journal of analytical toxicology, , Volume: 25, Issue:6, 2001

Levamisole-contaminated cocaine: a hairy affair.
BMJ case reports, , Aug-26, Volume: 2015, 2015

Myeloperoxidase and C-reactive protein in patients with cocaine-associated chest pain.
The American journal of emergency medicine, , Volume: 31, Issue:4, 2013

Contaminated cocaine and antineutrophil cytoplasmic antibody-associated disease.
Clinical journal of the American Society of Nephrology : CJASN, , Volume: 6, Issue:12, 2011

Clinical and immunological features of drug-induced and infection-induced proteinase 3-antineutrophil cytoplasmic antibodies and myeloperoxidase-antineutrophil cytoplasmic antibodies and vasculitis.
Current opinion in rheumatology, , Volume: 22, Issue:1, 2010

Editorial comment on: Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use.
European urology, , Volume: 52, Issue:2, 2007

Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use.
European urology, , Volume: 52, Issue:2, 2007

Association Between HLA-DPB1 and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Children.
Arthritis & rheumatology (Hoboken, N.J.), , Volume: 75, Issue:6, 2023

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

No association between myeloperoxidase gene rs2333227 G>A polymorphism and Alzheimer's disease risk: a meta-analysis and trial sequential analysis.
Journal of integrative neuroscience, , Jan-28, Volume: 21, Issue:1, 2022

CircRNA_0079586 and circRNA_RanGAP1 are involved in the pathogenesis of intracranial aneurysms rupture by regulating the expression of MPO.
Scientific reports, , 10-05, Volume: 11, Issue:1, 2021

An update on genetic basis of generalized pustular psoriasis (Review).
International journal of molecular medicine, , Volume: 47, Issue:6, 2021

Myeloperoxidase and CYBA genetic variants in polycystic ovary syndrome.
European journal of clinical investigation, , Volume: 51, Issue:4, 2021

Genetic Analysis of MPO Variants in Four Psoriasis Subtypes in Patients from Germany.
The Journal of investigative dermatology, , Volume: 141, Issue:8, 2021

[no title available]
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, , Volume: 120, Issue:7. Vyp. 2, 2020

SNP rs2243828 in MPO associated with myeloperoxidase level and atrial fibrillation risk in Chinese Han population.
Journal of cellular and molecular medicine, , Volume: 24, Issue:17, 2020

The Role of Inflammation and Myeloperoxidase-Related Oxidative Stress in the Pathogenesis of Genetically Triggered Thoracic Aortic Aneurysms.
International journal of molecular sciences, , Oct-16, Volume: 21, Issue:20, 2020

Distinct HLA and non-HLA associations in different subtypes of ANCA-associated vasculitides in North India.
International journal of rheumatic diseases, , Volume: 23, Issue:7, 2020

The -463G/A and -129G/A myeloperoxidase-encoding gene polymorphism in chronic obstructive pulmonary disease.
Advances in respiratory medicine, , Volume: 88, Issue:2, 2020

Genetic Variants rs1049255 CYBA and rs2333227 MPO are Associated with Susceptibility to Coronary Artery Disease in Russian Residents of Central Russia.
Kardiologiia, , Nov-12, Volume: 60, Issue:10, 2020

Are PR3 positive and MPO positive GPA the same disease?
International journal of rheumatic diseases, , Volume: 22 Suppl 1, 2019

PR3-ANCA-associated vasculitis is associated with a specific motif in the peptide-binding cleft of HLA-DP molecules.
Rheumatology (Oxford, England), , 11-01, Volume: 58, Issue:11, 2019

Associations of the NRF2/KEAP1 pathway and antioxidant defense gene polymorphisms with chronic obstructive pulmonary disease.
Gene, , Apr-15, Volume: 692, 2019

Relation of MPO, MnSOD, NQO1 gene variants in endometrial carcinoma in the line of PCR-RFLP methods.
Cellular and molecular biology (Noisy-le-Grand, France), , Mar-31, Volume: 64, Issue:4, 2018

The possible association between the presence of an MPO -463 G > A (rs2333227) polymorphism and cervical cancer risk.
Pathology, research and practice, , Volume: 214, Issue:8, 2018

Evaluation of the oxidative stress-related genes ALOX5, ALOX5AP, GPX1, GPX3 and MPO for contribution to the risk of type 2 diabetes mellitus in the Han Chinese population.
Diabetes & vascular disease research, , Volume: 15, Issue:4, 2018

Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis.
Renal failure, , Volume: 40, Issue:1, 2018

Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects.
Molecular biology reports, , Volume: 45, Issue:5, 2018

[no title available]
Cancer research, , 05-15, Volume: 78, Issue:10, 2018

Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis.
Arthritis & rheumatology (Hoboken, N.J.), , Volume: 69, Issue:5, 2017

The genetic influence in fluorosis.
Environmental toxicology and pharmacology, , Volume: 56, 2017

Association between MPO-463G > A polymorphism and cancer risk: evidence from 60 case-control studies.
World journal of surgical oncology, , Aug-02, Volume: 15, Issue:1, 2017

Myeloperoxidase polymorphism and coronary artery disease risk: A meta-analysis.
Medicine, , Volume: 96, Issue:27, 2017

Involvement of myeloperoxidase gene polymorphism 463G>A in development of cervical squamous cell carcinoma.
The International journal of biological markers, , Dec-23, Volume: 31, Issue:4, 2016

Myeloperoxidase genetic polymorphisms and susceptibility to Kawasaki disease in Taiwanese children.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, , Volume: 49, Issue:5, 2016

Polymorphisms of eNOS, catalase, and myeloperoxidase genes in prostate cancer in Turkish men: preliminary results.
Genetics and molecular research : GMR, , Aug-19, Volume: 15, Issue:3, 2016

Association of -463G/A MPO gene polymorphism and risk of cervical intraepithelial neoplasia.
Archives of gynecology and obstetrics, , Volume: 293, Issue:4, 2016

Cysteinyl-glycine reduces mucosal proinflammatory cytokine response to fMLP in a parenterally-fed piglet model.
Pediatric research, , Volume: 80, Issue:2, 2016

Recent pathogenetic advances in ANCA-associated vasculitis.
Presse medicale (Paris, France : 1983), , Volume: 44, Issue:6 Pt 2, 2015

Gender-specific protective effect of the -463G>A polymorphism of myeloperoxidase gene against the risk of essential hypertension in Russians.
Journal of the American Society of Hypertension : JASH, , Volume: 9, Issue:11, 2015

Association of single nucleotide polymorphisms in MPO and COX genes with oral lichen planus.
International journal of immunogenetics, , Volume: 42, Issue:3, 2015

Association of myeloperoxidase polymorphism (G463A) with cervix cancer.
Molecular and cellular biochemistry, , Volume: 404, Issue:1-2, 2015

The association between myeloperoxidase 463G>A polymorphisms and risk of lung cancer in East-Asia population.
Journal of cancer research and therapeutics, , Volume: 11 Suppl 1, 2015

System study of MPO promoter high-frequency polymorphic variants on transcription factor network.
Gene, , Apr-15, Volume: 560, Issue:2, 2015

Genetic variation associates with susceptibility for cigarette smoke-induced neutrophilia in mice.
American journal of physiology. Lung cellular and molecular physiology, , Apr-01, Volume: 308, Issue:7, 2015

Genetic polymorphisms involved in the inflammatory response and lung cancer risk: a case-control study in Japan.
Cytokine, , Volume: 65, Issue:1, 2014

Susceptibility quantitative trait loci for pathogenic leucocytosis in SCG/Kj mice, a spontaneously occurring crescentic glomerulonephritis and vasculitis model.
Clinical and experimental immunology, , Volume: 177, Issue:1, 2014

Accumulation of oxidative stress-related gene polymorphisms and the risk of coronary heart disease events in patients with type 2 diabetes--an 8-year prospective study.
Atherosclerosis, , Volume: 235, Issue:2, 2014

Meta-analysis of myeloperoxidase gene polymorphism and coronary artery disease susceptibility.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, , Volume: 39, Issue:3, 2014

HapMap-based study on the association between MPO and GSTP1 gene polymorphisms and lung cancer susceptibility in Chinese Han population.
Acta pharmacologica Sinica, , Volume: 35, Issue:5, 2014

An association between MPO -463 G/A polymorphism and type 2 diabetes.
Folia biologica, , Volume: 60, Issue:3, 2014

Myeloperoxidase G463A polymorphism and risk of lung cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, , Volume: 35, Issue:1, 2014

L26. How antigens influence the disease: an immunologist point of view.
Presse medicale (Paris, France : 1983), , Volume: 42, Issue:4 Pt 2, 2013

Genetic polymorphisms of myeloperoxidase and their effect on hypertension.
Blood pressure, , Volume: 22, Issue:5, 2013

The myeloperoxidase -463G/A polymorphism and coronary artery disease risk: A meta-analysis of 1938 cases and 1990 controls.
Clinical biochemistry, , Volume: 46, Issue:16-17, 2013

Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension.
Molecular medicine reports, , Volume: 7, Issue:1, 2013

The MPO-463G>A polymorphism and lung cancer risk: a meta-analysis based on 22 case-control studies.
PloS one, , Volume: 8, Issue:6, 2013

Revisiting ANCA-associated vasculitis in systemic sclerosis: clinical, serological and immunogenetic factors.
Rheumatology (Oxford, England), , Volume: 52, Issue:10, 2013

Myeloperoxidase G463A polymorphism and lung cancer risk in Asians: a pooled analysis.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, , Volume: 34, Issue:5, 2013

Pathogenesis of ANCA-associated vasculitis: new possibilities for intervention.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 62, Issue:6, 2013

Myeloperoxidase polymorphism, menopausal status, and breast cancer risk: an update meta-analysis.
PloS one, , Volume: 8, Issue:8, 2013

Manganese superoxide dismutase Ile58Thr, catalase C-262T and myeloperoxidase G-463A gene polymorphisms in patients with prostate cancer: relation to advanced and metastatic disease.
BJU international, , Volume: 112, Issue:4, 2013

[Association between the myeloperoxidase gene polymorphisms and the susceptibility to prostate cancer: a case-control study in a Chinese population].
Actas urologicas espanolas, , Volume: 37, Issue:2, 2013

Association between MPO 463G>A polymorphism and risk of lung cancer: a meta-analysis.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, , Volume: 34, Issue:6, 2013

Myeloperoxidase G-463A polymorphism and susceptibility to coronary artery disease: a meta-analysis.
Gene, , Jul-10, Volume: 523, Issue:2, 2013

Increased resistance to Staphylococcus aureus endophthalmitis in BALB/c mice: Fas ligand is required for resolution of inflammation but not for bacterial clearance.
Infection and immunity, , Volume: 81, Issue:6, 2013

Association of myeloperoxidase G-463A gene polymorphism with diabetic nephropathy in Japanese type 2 diabetic subjects.
Endocrine journal, , Volume: 60, Issue:4, 2013

Antineutrophil cytoplasmic autoantibody-associated vasculitis in Chinese patients.
Clinical and experimental nephrology, , Volume: 17, Issue:5, 2013

ANCA-associated vasculitis with dual ANCA positivity in coexistence with mixed connective tissue disease.
Modern rheumatology, , Volume: 23, Issue:1, 2013

Extracellular calcium-sensing receptor/PTH knockout mice colons have increased Wnt/β-catenin signaling, reduced non-canonical Wnt signaling, and increased susceptibility to azoxymethane-induced aberrant crypt foci.
Laboratory investigation; a journal of technical methods and pathology, , Volume: 93, Issue:5, 2013

Association of the 463G-A myeloperoxidase gene polymorphism with gastric cancer risk.
Hepato-gastroenterology, , Volume: 59, Issue:115, 2012

[Relationship of MPO and NQO1 gene polymorphisms with susceptibility to acute leukemia].
Zhongguo shi yan xue ye xue za zhi, , Volume: 20, Issue:6, 2012

Common genetic variants in the myeloperoxidase and paraoxonase genes and the related cancer risk: a review.
Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews, , Volume: 30, Issue:4, 2012

Myeloperoxidase immunohistochemistry as a measure of disease activity in ulcerative colitis: association with ulcerative colitis-colorectal cancer, tumor necrosis factor polymorphism and RUNX3 methylation.
Inflammatory bowel diseases, , Volume: 18, Issue:2, 2012

Menopausal status modifies breast cancer risk associated with the myeloperoxidase (MPO) G463A polymorphism in Caucasian women: a meta-analysis.
PloS one, , Volume: 7, Issue:3, 2012

Oxidative balance and colon and rectal cancer: interaction of lifestyle factors and genes.
Mutation research, , Jun-01, Volume: 734, Issue:1-2, 2012

The association between polymorphisms in prooxidant or antioxidant enzymes (myeloperoxidase, SOD2, and CAT) and genes and prostate cancer risk in the Chinese population of Han nationality.
Clinical genitourinary cancer, , Volume: 10, Issue:4, 2012

Variants in the inflammatory IL6 and MPO genes modulate stroke susceptibility through main effects and gene-gene interactions.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 31, Issue:8, 2011

The myeloperoxidase-463 G>A polymorphism influences risk of colorectal cancer in southern China: a case-control study.
Asian Pacific journal of cancer prevention : APJCP, , Volume: 12, Issue:7, 2011

Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity.
Experimental & molecular medicine, , Jun-30, Volume: 43, Issue:6, 2011

Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphoma.
American journal of epidemiology, , Feb-15, Volume: 173, Issue:4, 2011

Genetic variation in myeloperoxidase modifies the association of serum α-tocopherol with aggressive prostate cancer among current smokers.
The Journal of nutrition, , Volume: 141, Issue:9, 2011

Genetic variation of myeloperoxidase gene contributes to preeclampsia: a preliminary association study in Turkish population.
Hypertension in pregnancy, , Volume: 30, Issue:4, 2011

Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 300, Issue:2, 2011

Homozygous mutations in PXDN cause congenital cataract, corneal opacity, and developmental glaucoma.
American journal of human genetics, , Sep-09, Volume: 89, Issue:3, 2011

The MPO -463G>A polymorphism and cancer risk: a meta-analysis based on 43 case-control studies.
Mutagenesis, , Volume: 25, Issue:4, 2010

[A meta analysis on the relationship between myeloperoxidase G-463A genetic polymorphisms and lung cancer susceptibility].
Zhongguo fei ai za zhi = Chinese journal of lung cancer, , Volume: 13, Issue:2, 2010

Insulin-like growth factors II exon 9 and E-cadherin-Pml I but not myeloperoxidase promoter-463, urokinase-ApaL I nor xeroderma pigmentosum polymorphisms are associated with higher susceptibility to leiomyoma.
Anticancer research, , Volume: 30, Issue:6, 2010

[Relationship between polymorphisms of myeloperoxidase gene and susceptibility of acute leukemia in Chinese Gansu population].
Zhongguo shi yan xue ye xue za zhi, , Volume: 18, Issue:6, 2010

Genetic variation of myeloperoxidase gene contributes to aggressive periodontitis: a preliminary association study in Turkish population.
Disease markers, , Volume: 28, Issue:2, 2010

Naturally occurring glycoalkaloids in potatoes aggravate intestinal inflammation in two mouse models of inflammatory bowel disease.
Digestive diseases and sciences, , Volume: 55, Issue:11, 2010

Association between myeloperoxidase polymorphisms and its plasma levels with severity of coronary artery disease.
Clinical biochemistry, , Volume: 43, Issue:1-2, 2010

Combined effect of oxidative stress-related gene polymorphisms on atherosclerosis.
Biochemical and biophysical research communications, , Feb-20, Volume: 379, Issue:4, 2009

The myeloperoxidase gene and its influence on myocardial infarction in a Swedish population: protective role of the -129A allele in women.
Coronary artery disease, , Volume: 20, Issue:5, 2009

Effect modification by smoking on the association between genetic polymorphisms in oxidative stress genes and colorectal cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , Volume: 18, Issue:8, 2009

Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols.
The British journal of nutrition, , Volume: 102, Issue:11, 2009

Genetic variation of myeloperoxidase gene contributes to atopic asthma susceptibility: a preliminary association study in Russian population.
The Journal of asthma : official journal of the Association for the Care of Asthma, , Volume: 46, Issue:5, 2009

Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis.
Hepatology (Baltimore, Md.), , Volume: 50, Issue:5, 2009

No relationship between neutrophil granulocyte activation and the myeloperoxidase gene - 129 G>A and - 463 G>A promoter polymorphisms: implications for investigations of cardiovascular disease.
Coronary artery disease, , Volume: 20, Issue:7, 2009

Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactions.
American journal of epidemiology, , Dec-15, Volume: 170, Issue:12, 2009

Differential adipokine response in genetically predisposed lean and obese rats during inflammation: a role in modulating experimental colitis?
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 297, Issue:5, 2009

-463 G/A myeloperoxidase promoter polymorphism in giant cell arteritis.
Annals of the rheumatic diseases, , Volume: 67, Issue:4, 2008

Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma.
Clinical reviews in allergy & immunology, , Volume: 34, Issue:3, 2008

Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma.
Cancer, , Mar-01, Volume: 112, Issue:5, 2008

Association of the NQO1, MPO, and XRCC1 polymorphisms and chromosome damage among workers at a petroleum refinery.
Journal of toxicology and environmental health. Part A, , Volume: 71, Issue:5, 2008

CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women.
Lung cancer (Amsterdam, Netherlands), , Volume: 60, Issue:1, 2008

Meta-analysis of myeloperoxidase G-463/A polymorphism in anti-neutrophil cytoplasmic autoantibody-positive vasculitis.
Clinical and experimental immunology, , Volume: 149, Issue:2, 2007

Lack of association of the -463 G/A myeloperoxidase promoter polymorphism with Behcet's disease in Italian patients.
Rheumatology (Oxford, England), , Volume: 46, Issue:10, 2007

Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility.
Lung cancer (Amsterdam, Netherlands), , Volume: 57, Issue:2, 2007

CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1.
Circulation, , Mar-27, Volume: 115, Issue:12, 2007

Genetic polymorphisms involved in toxicant-metabolizing enzymes and the risk of chronic benzene poisoning in Chinese occupationally exposed populations.
Xenobiotica; the fate of foreign compounds in biological systems, , Volume: 37, Issue:1, 2007

Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer.
Lung cancer (Amsterdam, Netherlands), , Volume: 57, Issue:1, 2007

[Genetic polymorphisms of MPO, NQO1, GSTP1, UGT1A6 associated with susceptibility of chronic benzene poisoning].
Wei sheng yan jiu = Journal of hygiene research, , Volume: 36, Issue:1, 2007

Analysis of multiple single nucleotide polymorphisms (SNPs) of myeloperoxidase (MPO) to screen for genetic markers associated with acute leukemia in Chinese Han population.
Journal of toxicology and environmental health. Part A, , Volume: 70, Issue:11, 2007

Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysis.
Genetics in medicine : official journal of the American College of Medical Genetics, , Volume: 9, Issue:2, 2007

[Study on polymorphisms in metabolic enzyme genes, DNA repair genes and individual susceptibility to hepatocellular carcinoma].
Wei sheng yan jiu = Journal of hygiene research, , Volume: 35, Issue:6, 2006

CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung.
Carcinogenesis, , Volume: 27, Issue:3, 2006

Genetic basis of toxic reactions to drugs and chemicals.
Toxicology letters, , Mar-15, Volume: 162, Issue:1, 2006

Myeloperoxidase -463G>A polymorphism and risk of primary lung cancer in a Korean population.
Cancer detection and prevention, , Volume: 30, Issue:3, 2006

Oxidative stress-related gene polymorphism and the risk of preeclampsia.
European journal of obstetrics, gynecology, and reproductive biology, , Mar-01, Volume: 119, Issue:1, 2005

Association of the G-463A myeloperoxidase polymorphism with infection in sickle cell anemia.
Haematologica, , Volume: 90, Issue:7, 2005

Opposing effects of emphysema, hay fever, and select genetic variants on lung cancer risk.
American journal of epidemiology, , Mar-01, Volume: 161, Issue:5, 2005

New insights that link microbes with the generation of antineutrophil cytoplasmic autoantibodies: the theory of autoantigen complementarity.
Current opinion in nephrology and hypertension, , Volume: 14, Issue:3, 2005

Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis.
Journal of hepatology, , Volume: 42, Issue:6, 2005

Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer.
Cancer research, , Feb-01, Volume: 65, Issue:3, 2005

Association of the myeloperoxidase -468G-->A polymorphism with gastric inflammation and duodenal ulcer risk.
World journal of gastroenterology, , May-14, Volume: 11, Issue:18, 2005

Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), , Volume: 14, Issue:3, 2005

[Study on polymorphisms in metabolic enzyme genes, DNA repair genes and individual susceptibility to childhood leukemia].
Wei sheng yan jiu = Journal of hygiene research, , Volume: 33, Issue:5, 2004

Genetic determination of TNF and myeloperoxidase production in dialyzed patients with diabetic nephropathy.
Renal failure, , Volume: 26, Issue:6, 2004

Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk.
Cancer research, , Oct-15, Volume: 64, Issue:20, 2004

Glucocorticoid-induced TNF receptor family gene (GITR) knockout mice exhibit a resistance to splanchnic artery occlusion (SAO) shock.
Journal of leukocyte biology, , Volume: 76, Issue:5, 2004

Genetic polymorphisms in the Hmong population: implications for cancer etiology and survival.
Cancer, , Jan-15, Volume: 100, Issue:2, 2004

Genetic impact of pathogenesis and prognosis of ANCA-associated vasculitides.
Clinical and experimental rheumatology, , Volume: 22, Issue:6 Suppl 36, 2004

Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms.
Archives of neurology, , Volume: 61, Issue:3, 2004

MPO and SOD2 polymorphisms, gender, and the risk of non-small cell lung carcinoma.
Cancer letters, , Oct-08, Volume: 214, Issue:1, 2004

Glutathione S-transferase M1*null genotype but not myeloperoxidase promoter G-463A polymorphism is associated with higher susceptibility to endometriosis.
Molecular human reproduction, , Volume: 10, Issue:10, 2004

[Gene polymorphism of myeloperoxidase and genetic susceptibility to lung cancer].
Ai zheng = Aizheng = Chinese journal of cancer, , Volume: 22, Issue:9, 2003

Myeloperoxidase gene variation as a determinant of atherosclerosis progression in the abdominal and thoracic aorta: an autopsy study.
Laboratory investigation; a journal of technical methods and pathology, , Volume: 83, Issue:7, 2003

Myeloperoxidase G-463A polymorphism and Alzheimer's disease in the ApoEurope study.
Neuroscience letters, , Oct-02, Volume: 349, Issue:2, 2003

Combined effect of MPO, GSTM1 and GSTT1 polymorphisms on chromosome aberrations and lung cancer risk.
International journal of hygiene and environmental health, , Volume: 206, Issue:6, 2003

Correspondence re: Feyler et al., Point: Myeloperoxidase (-463)G --> a polymorphism and lung cancer risk. Cancer Epidemiol. Biomark. Prev., 11: 1550-1554, 2002, and Xu et al., Counterpoint: The myeloperoxidase (-463)G --> a polymorphism does not decrease
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , Volume: 12, Issue:7, 2003

Myeloperoxidase polymorphisms in brain infarction. Association with infarct size and functional outcome.
Atherosclerosis, , Volume: 167, Issue:2, 2003

Helicobacter pylori seropositivity and the myeloperoxidase G-463A polymorphism in combination with interleukin-1B C-31T in Japanese health checkup examinees.
Japanese journal of clinical oncology, , Volume: 33, Issue:4, 2003

Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase.
Cancer letters, , Nov-10, Volume: 201, Issue:1, 2003

Genetic background of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis: association of HLA-DRB1*0901 with microscopic polyangiitis.
The Journal of rheumatology, , Volume: 30, Issue:7, 2003

A myeloperoxidase polymorphism associated with reduced risk of lung cancer.
Lung cancer (Amsterdam, Netherlands), , Volume: 37, Issue:1, 2002

Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , Volume: 11, Issue:12, 2002

Polymorphic metabolizing genes and susceptibility to atherosclerosis among cigarette smokers.
Environmental and molecular mutagenesis, , Volume: 40, Issue:3, 2002

Counterpoint: the myeloperoxidase -463G-->a polymorphism does not decrease lung cancer susceptibility in Caucasians.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , Volume: 11, Issue:12, 2002

Gender and smoking-related risk reduction of periodontal disease with variant myeloperoxidase alleles.
Genes and immunity, , Volume: 3, Issue:2, 2002

Molecular-epidemiological aspects of carcinogenesis: the role of xenobiotic metabolizing enzymes.
International journal of clinical pharmacology and therapeutics, , Volume: 40, Issue:12, 2002

[Lung cancer risk associated with genetic polymorphism in myeloperoxidase (-463 G/A) in a Chinese population].
Zhonghua zhong liu za zhi [Chinese journal of oncology], , Volume: 24, Issue:3, 2002

New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis.
Autoimmunity reviews, , Volume: 1, Issue:1-2, 2002

Genetic susceptibility of term pregnant women to oxidative damage.
Toxicology letters, , Mar-28, Volume: 129, Issue:3, 2002

Myeloperoxidase -463 (G-->A) polymorphism associated with lower risk of lung cancer.
Mayo Clinic proceedings, , Volume: 77, Issue:1, 2002

Genetic background determines susceptibility during murine septic peritonitis.
The Journal of surgical research, , Volume: 102, Issue:1, 2002

Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia.
International journal of cancer, , Jan-10, Volume: 97, Issue:2, 2002

[Unusual manifestations of autoimmune thyroiditis].
Praxis, , Jul-03, Volume: 91, Issue:27-28, 2002

Possible risk reduction in esophageal cancer associated with MPO -463 A allele.
Journal of epidemiology, , Volume: 11, Issue:3, 2001

Novel SNPs in the CD18 gene validate the association with MPO-ANCA+ vasculitis.
Genes and immunity, , Volume: 2, Issue:5, 2001

Gene-environment interaction in the expression of antioxidant status: a role for genes in the relationship between smoking and coronary disease.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 21, Issue:7, 2001

Susceptibility to cerulein-induced pancreatitis in inducible nitric oxide synthase-deficient mice.
Pancreas, , Volume: 23, Issue:1, 2001

PECAM1, MPO and PRKAR1A at chromosome 17q21-q24 and susceptibility for multiple sclerosis in Sweden and Sardinia.
Journal of neuroimmunology, , Aug-01, Volume: 108, Issue:1-2, 2000

Differential host susceptibility to pulmonary infections with bacteria and fungi in mice deficient in myeloperoxidase.
The Journal of infectious diseases, , Volume: 182, Issue:4, 2000

Genetic variants of myeloperoxidase and lung cancer risk.
Carcinogenesis, , Volume: 21, Issue:6, 2000

Susceptibility of Lewis and Fischer rats to stress-induced worsening of TNB-colitis: protective role of brain CRF.
The American journal of physiology, , Volume: 276, Issue:4, 1999

Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease.
Experimental neurology, , Volume: 155, Issue:1, 1999

Polymorphism in the TNF-alpha gene promoter at position -1031 is associated with increased circulating levels of TNF-alpha, myeloperoxidase and nitrotyrosine in primary Sjögren's syndrome.
Clinical and experimental rheumatology, , Volume: 30, Issue:6

Association of the myeloperoxidase polymorphism with the risk of gastric cancer.
Anticancer research, , Volume: 28, Issue:2B

Model for gene-environment interaction: the case for dialysis.
Seminars in dialysis, , Volume: 18, Issue:1

[Genetic and biochemical mechanisms of involvement of antioxidant defense enzymes in the development of bronchial asthma].
Biomeditsinskaia khimiia, , Volume: 61, Issue:4

Epstein-Barr virus reactivation induced myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis.
BMJ case reports, , Oct-07, Volume: 14, Issue:10, 2021

Clinical interpretation of antineutrophil cytoplasmic antibodies: parvovirus B19 infection as a pitfall.
Annals of the rheumatic diseases, , Volume: 64, Issue:4, 2005

[ERRORS IN DIAGNOSIS AND TREATMENT OF IMMUNODEPENDENT PATHOLOGY (ORIGINAL CONCEPT)].
Likars'ka sprava, , Issue:7-8

COVID-19 associated Kikuchi-Fujimoto disease.
British journal of haematology, , Volume: 192, Issue:5, 2021

Cutting needle biopsy combined with immunohistochemical study of myeloperoxidase for the diagnosis of histiocytic necrotizing lymphadenitis.
Acta oto-laryngologica, , Volume: 133, Issue:12, 2013

Histiocytic necrotizing lymphadenitis in children: a clinical and immunohistochemical comparative study with adult patients.
International journal of pediatric otorhinolaryngology, , Volume: 77, Issue:3, 2013

Phenotype for activated tissue macrophages in histiocytic necrotizing lymphadenitis.
Pathology international, , Volume: 59, Issue:9, 2009

The histiocytic component of cutaneous manifestations of Kikuchi disease expresses myeloperoxidase.
Applied immunohistochemistry & molecular morphology : AIMM, , Volume: 16, Issue:2, 2008

Histiocytic necrotizing lymphadenitis without granulocytic infiltration (the so called Kikuchi-Fujimoto disease).
Polish journal of pathology : official journal of the Polish Society of Pathologists, , Volume: 59, Issue:1, 2008

Immunohistochemical detection of Kikuchi's lymphadenitis.
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA, , Volume: 23, Issue:7, 2003

[The diagnosis and differential diagnosis of histiocytic necrotizing lymphadenitis. A study of histology, immunohistochemistry and electron microscopy].
Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 32, Issue:6, 2003

Myeloperoxidase expression by histiocytes in Kikuchi's and Kikuchi-like lymphadenopathy.
The American journal of pathology, , Volume: 159, Issue:3, 2001

Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome.
Acta cirurgica brasileira, , Volume: 29, Issue:9, 2014

Clinical significance of a myeloperoxidase gene polymorphism and inducible nitric oxide synthase expression in cirrhotic patients with hepatopulmonary syndrome.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, , Volume: 30, Issue:4, 2010

Interleukin-10 inhibits pulmonary NF-kappaB activation and lung injury induced by hepatic ischemia-reperfusion.
The American journal of physiology, , Volume: 277, Issue:5, 1999

Myeloperoxidase activity is increased in hepatopulmonary syndrome in rats.
Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery, , Volume: 26, Issue:4

Morin decreases cortical pyramidal neuron degeneration via inhibition of neuroinflammation in mouse model of schizophrenia.
International immunopharmacology, , Volume: 70, 2019

Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis.
Critical care medicine, , Volume: 38, Issue:2, 2010

The capsaicin VR1 receptor mediates substance P release in toxin A-induced enteritis in rats.
Peptides, , Volume: 22, Issue:9, 2001

Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis.
Proceedings of the National Academy of Sciences of the United States of America, , Sep-16, Volume: 111, Issue:37, 2014

Generation of neutrophil extracellular traps in patients with acute liver failure is associated with poor outcome.
Hepatology (Baltimore, Md.), , Volume: 75, Issue:3, 2022

Manganese promotes increased formation of hydrogen peroxide by activated human macrophages and neutrophils in vitro.
Inhalation toxicology, , Volume: 24, Issue:10, 2012

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease.
American journal of physiology. Gastrointestinal and liver physiology, , Oct-01, Volume: 323, Issue:4, 2022

[Expression of intercellular adhesion molecule-1 and myeloperoxidase in peripheral blood and its significance in elderly patients with OSAHS].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, , Aug-20, Volume: 31, Issue:16, 2017

[Expression and significance of serum hepatocyte growth factor and myeloperoxidase in patients with obstructive sleep apnea hypopnea syndrome].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, , Jun-05, Volume: 31, Issue:11, 2017

[Determination and significance of serum MPO and amylin in adult patients with OSAHS after short-range noninvasive positive pressure ventilation].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, , Jun-05, Volume: 31, Issue:11, 2017

The Relationship Among Oxidative and Anti-Oxidative Parameters and Myeloperoxidase in Subjects With Obstructive Sleep Apnea Syndrome.
Respiratory care, , Volume: 61, Issue:2, 2016

Effect of Continuous Positive Airway Pressure on Cardiovascular Biomarkers: The Sleep Apnea Stress Randomized Controlled Trial.
Chest, , Volume: 150, Issue:1, 2016

Do salivary and serum collagenases have a role in an association between obstructive sleep apnea syndrome and periodontal disease? A preliminary case-control study.
Archives of oral biology, , Volume: 60, Issue:1, 2015

Increased plasma soluble tumor necrosis factor receptor-1 and myeloperoxidase activity in patients with obstructive sleep apnea syndrome.
The International journal of neuroscience, , Volume: 125, Issue:9, 2015

Salivary and serum myeloperoxidase in obstructive sleep apnea.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, , Jun-01, Volume: 41, Issue:3, 2012

An experimental research on chronic intermittent hypoxia leading to liver injury.
Sleep & breathing = Schlaf & Atmung, , Volume: 15, Issue:3, 2011

Oxidative stress markers in pregnant women who snore and fetal outcome: a case control study.
Acta obstetricia et gynecologica Scandinavica, , Volume: 86, Issue:11, 2007

Treatment with amnion-derived cellular cytokine solution (ACCS) induces persistent motor improvement and ameliorates neuroinflammation in a rat model of penetrating ballistic-like brain injury.
Restorative neurology and neuroscience, , Volume: 33, Issue:2, 2015

Differential effects of chlorinated and oxidized phospholipids in vascular tissue: implications for neointima formation.
Clinical science (London, England : 1979), , Volume: 128, Issue:9, 2015

Intra-Articular Blockade of P2X7 Receptor Reduces the Articular Hyperalgesia and Inflammation in the Knee Joint Synovitis Especially in Female Rats.
The journal of pain, , Volume: 18, Issue:2, 2017

Effect of delayed mild brain hypothermia on edema formation after intracerebral hemorrhage in rats.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 17, Issue:4

MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma.
International journal of molecular sciences, , Jan-28, Volume: 21, Issue:3, 2020

Association of Pulmonary Hemorrhage, Positive Proteinase 3, and Urinary Red Blood Cell Casts With Venous Thromboembolism in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Arthritis & rheumatology (Hoboken, N.J.), , Volume: 71, Issue:11, 2019

Histological criteria for age determination of fatal venous thromboembolism.
International journal of legal medicine, , Volume: 132, Issue:3, 2018

[Case of cerebral venous thrombosis caused by MPO-ANCA associated hypertrophic pachymeningitis].
Rinsho shinkeigaku = Clinical neurology, , Volume: 54, Issue:10, 2014

Systemically circulating oxidative species in human deep venous thrombosis.
European journal of emergency medicine : official journal of the European Society for Emergency Medicine, , Volume: 5, Issue:1, 1998

Anti-neutrophil cytoplasmic antibodies in 566 European patients with systemic lupus erythematosus: prevalence, clinical associations and correlation with other autoantibodies. European Concerted Action on the Immunogenetics of SLE.
Clinical and experimental rheumatology, , Volume: 16, Issue:5

Histone deacetylase inhibitor, mocetinostat, regulates cardiac remodelling and renin-angiotensin system activity in rats with transverse aortic constriction-induced pressure overload cardiac hypertrophy.
Reviews in cardiovascular medicine, , Sep-24, Volume: 22, Issue:3, 2021

The expression of myeloperoxidase in thrombi is associated with reduced heme oxygenase-1 induction and worse left ventricular remodeling in patients with acute ST-elevation myocardial infarction.
Clinical cardiology, , Volume: 44, Issue:3, 2021

Neutrophil-Mediated Cardiac Damage After Acute Myocardial Infarction: Significance of Defining a New Target Cell Type for Developing Cardioprotective Drugs.
Antioxidants & redox signaling, , 10-01, Volume: 33, Issue:10, 2020

Pharmacological myeloperoxidase (MPO) inhibition in an obese/hypertensive mouse model attenuates obesity and liver damage, but not cardiac remodeling.
Scientific reports, , 12-10, Volume: 9, Issue:1, 2019

Memantine, an NMDA receptor antagonist, attenuates cardiac remodeling, lipid peroxidation and neutrophil recruitment in heart failure: A cardioprotective agent?
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 108, 2018

Relation between high levels of myeloperoxidase in the culprit artery and microvascular obstruction, infarct size and reverse remodeling in ST-elevation myocardial infarction.
PloS one, , Volume: 12, Issue:7, 2017

Immune Modulation of Cardiac Arrhythmias.
Circulation research, , 06-23, Volume: 121, Issue:1, 2017

Transplantation of Epigenetically Modified Adult Cardiac c-Kit+ Cells Retards Remodeling and Improves Cardiac Function in Ischemic Heart Failure Model.
Stem cells translational medicine, , Volume: 4, Issue:9, 2015

Preventive effect of yuzu and hesperidin on left ventricular remodeling and dysfunction in rat permanent left anterior descending coronary artery occlusion model.
PloS one, , Volume: 10, Issue:1, 2015

Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats.
Microcirculation (New York, N.Y. : 1994), , Volume: 20, Issue:1, 2013

Acute aortocaval fistula: role of low perfusion pressure and subendocardial remodeling on left ventricular function.
International journal of experimental pathology, , Volume: 94, Issue:3, 2013

Early measurements of plasma matrix metalloproteinase-2 predict infarct size and ventricular dysfunction in ST-elevation myocardial infarction.
Heart (British Cardiac Society), , Volume: 98, Issue:1, 2012

Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism.
Circulation research, , Mar-02, Volume: 110, Issue:5, 2012

Critical role for white blood cell NAD(P)H oxidase-mediated plasminogen activator inhibitor-1 oxidation and ventricular rupture following acute myocardial infarction.
Journal of molecular and cellular cardiology, , Volume: 50, Issue:3, 2011

'Turning the right screw': targeting the interleukin-6 receptor to reduce unfavourable tissue remodelling after myocardial infarction.
Cardiovascular research, , Aug-01, Volume: 87, Issue:3, 2010

Antibody against interleukin-6 receptor attenuates left ventricular remodelling after myocardial infarction in mice.
Cardiovascular research, , Aug-01, Volume: 87, Issue:3, 2010

Comparison of vasopeptidase inhibitor omapatrilat and angiotensin receptor blocker candesartan on extracellular matrix, myeloperoxidase, cytokines, and ventricular remodeling during healing after reperfused myocardial infarction.
Molecular and cellular biochemistry, , Volume: 321, Issue:1-2, 2009

The role of leukocyte-generated oxidants in left ventricular remodeling.
The American journal of cardiology, , May-22, Volume: 101, Issue:10A, 2008

Low coronary driving pressure is associated with subendocardial remodelling and left ventricular dysfunction in aortocaval fistula.
Clinical and experimental pharmacology & physiology, , Volume: 34, Issue:11, 2007

Effects of timed administration of doxycycline or methylprednisolone on post-myocardial infarction inflammation and left ventricular remodeling in the rat heart.
Molecular and cellular biochemistry, , Volume: 300, Issue:1-2, 2007

Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction.
Circulation, , Nov-01, Volume: 112, Issue:18, 2005

Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction.
The Journal of experimental medicine, , Mar-03, Volume: 197, Issue:5, 2003

Tyrphostin AG-556 reduces myocardial infarct size and improves cardiac performance in the rat.
Experimental and molecular pathology, , Volume: 74, Issue:3, 2003

Investigation of neurotoxic and immunotoxic effects of some plant growth regulators at subacute and subchronic applications on rats.
Toxicology and industrial health, , Volume: 31, Issue:12, 2015

Effects of the compounds resveratrol, rutin, quercetin, and quercetin nanoemulsion on oxaliplatin-induced hepatotoxicity and neurotoxicity in mice.
Naunyn-Schmiedeberg's archives of pharmacology, , Volume: 387, Issue:9, 2014

Interleukin-10 overexpression does not synergize with the neuroprotective action of RGD-containing vectors after postnatal brain excitotoxicity but modulates the main inflammatory cell responses.
Journal of neuroscience research, , Volume: 90, Issue:1, 2012

Evaluation of the serum catalase and myeloperoxidase activities in chronic arsenic-exposed individuals and concomitant cytogenetic damage.
Toxicology and applied pharmacology, , Nov-15, Volume: 249, Issue:1, 2010

Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase.
Cancer letters, , Nov-10, Volume: 201, Issue:1, 2003

Neuroprotective effects of α-ketoglutarate and ethyl pyruvate against motor dysfunction and oxidative changes caused by repeated 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine exposure in mice.
Human & experimental toxicology, , Volume: 32, Issue:7, 2013

Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats.
Inflammopharmacology, , Volume: 20, Issue:6, 2012

[A study of free radical defense and oxidative stress in the sera of patients with neuroimmunological disorders].
Arerugi = [Allergy], , Volume: 49, Issue:1, 2000

Mimicking the mimicker: Necrotizing sarcoid granulomatosis.
The American journal of the medical sciences, , Volume: 364, Issue:4, 2022

Characteristics of MPO-ANCA-positive granulomatosis with polyangiitis: a retrospective multi-center study in Japan.
Rheumatology international, , Volume: 35, Issue:3, 2015

ADAMTS13 reduces VWF-mediated acute inflammation following focal cerebral ischemia in mice.
Journal of thrombosis and haemostasis : JTH, , Volume: 10, Issue:8, 2012

Multiple bilateral non-hemorrhagic cerebral infarctions associated with microscopic polyangiitis.
Clinical neurology and neurosurgery, , Volume: 111, Issue:10, 2009

P-ANCA cranial pachymeningitis: a case report.
Clinical rheumatology, , Volume: 24, Issue:2, 2005

[Case of the month. Wegener's disease].
Revue medicale de Liege, , Volume: 58, Issue:1, 2003

[Eosinophilic meningoencephalitis in a case of rheumatoid arthritis].
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, , Volume: 21, Issue:5, 1998

Umbilical cord serum interleukin-6, C-reactive protein, and myeloperoxidase concentrations at birth and association with neonatal morbidities and long-term neurodevelopmental outcomes.
American journal of perinatology, , Volume: 31, Issue:8, 2014

Multiple atherosclerosis-related biomarkers associated with short- and long-term mortality after stroke.
Clinical biochemistry, , Volume: 45, Issue:16-17, 2012

The predictive value of serum myeloperoxidase for vasospasm in patients with aneurysmal subarachnoid hemorrhage.
Neurosurgical review, , Volume: 35, Issue:3, 2012

Alpha lipoic acid alleviates oxidative stress and preserves blood brain permeability in rats with subarachnoid hemorrhage.
Neurochemical research, , Volume: 35, Issue:3, 2010

No apparent role for neutrophils and neutrophil-derived myeloperoxidase in experimental subarachnoid haemorrhage and vasospasm: a preliminary study.
Acta neurochirurgica, , Volume: 142, Issue:1, 2000

Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis.
Journal of neuroinflammation, , Feb-07, Volume: 14, Issue:1, 2017

The upper thoracic spinal cord compression as the initial manifestation of Wegener's granulomatosis: a case report.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, , Volume: 16 Suppl 3, 2007

Dose-dependent effects of adalimumab in neonatal rats with hypoxia/reoxygenation-induced intestinal damage.
Bosnian journal of basic medical sciences, , Feb-01, Volume: 21, Issue:1, 2021

Inhibition of A
Mediators of inflammation, , Volume: 2020, 2020

Ginger (Zingiber officinale Roscoe) for the treatment and prevention of necrotizing enterocolitis.
Journal of ethnopharmacology, , Oct-28, Volume: 225, 2018

The effect of vascular endothelial growth factor overexpression in experimental necrotizing enterocolitis.
Pediatric surgery international, , Volume: 30, Issue:3, 2014

Umbilical cord serum interleukin-6, C-reactive protein, and myeloperoxidase concentrations at birth and association with neonatal morbidities and long-term neurodevelopmental outcomes.
American journal of perinatology, , Volume: 31, Issue:8, 2014

Beneficial effects of Nigella sativa oil on intestinal damage in necrotizing enterocolitis.
Journal of investigative surgery : the official journal of the Academy of Surgical Research, , Volume: 25, Issue:5, 2012

Protective effects of caffeic acid phenethyl ester (CAPE) on intestinal damage in necrotizing enterocolitis.
Pediatric surgery international, , Volume: 27, Issue:11, 2011

Protective effect of tumor necrosis factor alpha antibody on experimental necrotizing enterocolitis in the rat.
Journal of pediatric surgery, , Volume: 40, Issue:9, 2005

Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology.
PloS one, , Volume: 11, Issue:1, 2016

Sida tuberculata reduces oxidative stress and pain caused by the knee osteoarthritis.
Journal of ethnopharmacology, , Feb-10, Volume: 248, 2020

Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial.
BMC complementary and alternative medicine, , May-17, Volume: 14, 2014

One-year follow-up of Coll2-1, Coll2-1NO2 and myeloperoxydase serum levels in osteoarthritis patients after hip or knee replacement.
Annals of the rheumatic diseases, , Volume: 67, Issue:2, 2008

Myeloperoxidase and chlorinated peptides in osteoarthritis: potential biomarkers of the disease.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, , Volume: 25, Issue:9, 2007

Effect of Mud-Bath Therapy on Serum Biomarkers in Patients with Knee Osteoarthritis: Results from a Randomized Controlled Trial.
The Israel Medical Association journal : IMAJ, , Volume: 18, Issue:3-4

Hypochlorous acid exposure impairs skeletal muscle function and Ca
The Journal of physiology, , Volume: 601, Issue:23, 2023

Oxidative damage to urinary proteins from the GRMD dog and mdx mouse as biomarkers of dystropathology in Duchenne muscular dystrophy.
PloS one, , Volume: 15, Issue:10, 2020

Levels of inflammation and oxidative stress, and a role for taurine in dystropathology of the Golden Retriever Muscular Dystrophy dog model for Duchenne Muscular Dystrophy.
Redox biology, , Volume: 9, 2016

Immunohistochemical staining of dystrophin on formalin-fixed paraffin-embedded sections in Duchenne/Becker muscular dystrophy and manifesting carriers of Duchenne muscular dystrophy.
Neuromuscular disorders : NMD, , Volume: 10, Issue:6, 2000

Association Between IL-5 Levels and the Clinicopathologic Features of Eosinophilic Granulomatosis With Polyangiitis.
Neurology, , 02-02, Volume: 96, Issue:5, 2021

Polyangiitis overlap syndrome: a novel presentation of microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis.
BMJ case reports, , Feb-01, Volume: 14, Issue:2, 2021

Eosinophilic granulomatosis with polyangiitis presenting with myositis: case based review.
Rheumatology international, , Volume: 40, Issue:7, 2020

A case of MPO-ANCA-positive polyarteritis nodosa complicated by exudative otitis media, mononeuritis multiplex, and acute renal failure.
Clinical and experimental nephrology, , Volume: 15, Issue:5, 2011

Effect of simvastatin on sensorial, motor, and morphological parameters in sciatic nerve crush induced-neuropathic pain in rats.
Inflammopharmacology, , Volume: 26, Issue:3, 2018

Attenuating effect of Acorus calamus extract in chronic constriction injury induced neuropathic pain in rats: an evidence of anti-oxidative, anti-inflammatory, neuroprotective and calcium inhibitory effects.
BMC complementary and alternative medicine, , Mar-22, Volume: 11, 2011

Human amniotic fluid mesenchymal stem cells in combination with hyperbaric oxygen augment peripheral nerve regeneration.
Neurochemical research, , Volume: 34, Issue:7, 2009

Ameliorative potential of rosiglitazone in tibial and sural nerve transection-induced painful neuropathy in rats.
Pharmacological research, , Volume: 59, Issue:6, 2009

Anti-hypernociceptive properties of agmatine in persistent inflammatory and neuropathic models of pain in mice.
Brain research, , Jul-23, Volume: 1159, 2007

Medial medullary infarction caused by antineutrophil cytoplasmic antibody-related vasculitis: Case report and review of the literature.
Medicine, , Volume: 96, Issue:33, 2017

Dysfunctional HDL in acute stroke.
Atherosclerosis, , Volume: 253, 2016

Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke.
Journal of neuroinflammation, , 05-24, Volume: 13, Issue:1, 2016

Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia.
Experimental neurology, , Volume: 264, 2015

The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke.
Neuropharmacology, , Volume: 81, 2014

Impact of the neutrophil response to granulocyte colony-stimulating factor on the risk of hemorrhage when used in combination with tissue plasminogen activator during the acute phase of experimental stroke.
Journal of neuroinflammation, , May-27, Volume: 11, 2014

Neuroprotective effect of naringenin is mediated through suppression of NF-κB signaling pathway in experimental stroke.
Neuroscience, , Jan-29, Volume: 230, 2013

Immune following suppression mesenchymal stem cell transplantation in the ischemic brain is mediated by TGF-β.
Neurobiology of disease, , Volume: 58, 2013

Gradient echo T2*-weighted magnetic resonance imaging revealing cerebral microbleeds in a patient with microscopic polyangiitis complicated by cerebrovascular disease.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 21, Issue:8, 2012

Tropisetron ameliorates ischemic brain injury in an embolic model of stroke.
Brain research, , May-25, Volume: 1392, 2011

Spatio-temporal distribution of inflammatory reaction and expression of TLR2/4 signaling pathway in rat brain following permanent focal cerebral ischemia.
Neurochemical research, , Volume: 35, Issue:8, 2010

The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury.
Journal of neurochemistry, , Volume: 113, Issue:4, 2010

Neuroprotective efficacy and therapeutic window of Forsythoside B: in a rat model of cerebral ischemia and reperfusion injury.
European journal of pharmacology, , Aug-25, Volume: 640, Issue:1-3, 2010

Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation.
Journal of neurochemistry, , Volume: 104, Issue:2, 2008

[Case of multiple brain infarction with MPO-ANCA].
Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 60, Issue:9, 2008

Synthetic fibronectin peptide exerts neuroprotective effects on transient focal brain ischemia in rats.
Brain research, , Aug-23, Volume: 1054, Issue:1, 2005

17beta-estradiol potentiates ischemia-reperfusion injury in diabetic ovariectomized female rats.
Brain research, , Aug-30, Volume: 1054, Issue:2, 2005

Neuroprotective effects of (S)-N-[4-[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)carbonyl]-1-piperazinyl]phenyl]-2-thiophenecarboximid-amide (BN 80933), an inhibitor of neuronal nitric-oxide synthase and an antioxidant, in model of
The Journal of pharmacology and experimental therapeutics, , Volume: 306, Issue:2, 2003

3-Aminobenzamide reduces brain infarction and neutrophil infiltration after transient focal cerebral ischemia in mice.
Experimental neurology, , Volume: 184, Issue:2, 2003

Myeloperoxidase polymorphisms in brain infarction. Association with infarct size and functional outcome.
Atherosclerosis, , Volume: 167, Issue:2, 2003

Deficiency of myeloperoxidase increases infarct volume and nitrotyrosine formation in mouse brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 22, Issue:1, 2002

Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody: a bedside-to-bench study.
Stroke, , Volume: 32, Issue:11, 2001

Progesterone inhibits inflammatory response pathways after permanent middle cerebral artery occlusion in rats.
Molecular medicine reports, , Volume: 4, Issue:2

Association between myeloperoxidase and the risks of ischemic stroke, heart failure, and atrial fibrillation: A Mendelian randomization study.
Nutrition, metabolism, and cardiovascular diseases : NMCD, , Volume: 33, Issue:1, 2023

The value of serum Lp-PLA2 combined with MPO in the diagnosis of cerebral infarction caused by large artery atherosclerosis.
Clinical neurology and neurosurgery, , Volume: 232, 2023

Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia.
Frontiers in immunology, , Volume: 13, 2022

Myeloperoxidase is Independently Associated with Incident Heart Failure in Patients with Coronary Artery Disease and Kidney Disease.
Current problems in cardiology, , Volume: 47, Issue:11, 2022

Exploratory Investigation of Intestinal Structure and Function after Stroke in Mice.
Mediators of inflammation, , Volume: 2021, 2021

DNA Hypomethylation of the MPO Gene in Peripheral Blood Leukocytes Is Associated with Cerebral Stroke in the Acute Phase.
Journal of molecular neuroscience : MN, , Volume: 71, Issue:9, 2021

Neutrophil extracellular traps (NETs) infiltrate haematoma and surrounding brain tissue after intracerebral haemorrhage: A post-mortem study.
Neuropathology and applied neurobiology, , Volume: 47, Issue:6, 2021

Analysis of the association of MPO and MMP-9 with stroke severity and outcome: Cohort study.
Neurology, , 07-07, Volume: 95, Issue:1, 2020

Plasma myeloperoxidase levels in acute brain ischaemia and high grade carotid stenosis.
European journal of neurology, , Volume: 27, Issue:8, 2020

Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke.
Life sciences, , Jan-01, Volume: 216, 2019

Impaired antioxidative activity of high-density lipoprotein is associated with more severe acute ischemic stroke.
Metabolism: clinical and experimental, , Volume: 98, 2019

Recognizing Central Nervous System Involvement as a Progressive Feature of Microscopic Polyangiitis: A Diagnostic Dilemma.
The American journal of medicine, , Volume: 132, Issue:9, 2019

Serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase and myeloperoxidase in ischemic stroke.
Atherosclerosis, , Volume: 271, 2018

Inhibition of Myeloperoxidase by
The Journal of pharmacology and experimental therapeutics, , Volume: 364, Issue:2, 2018

Genetic Variations of Oxidative Stress Related Genes ALOX5, ALOX5AP and MPO Modulate Ischemic Stroke Susceptibility Through Main Effects and Epistatic Interactions in a Chinese Population.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , Volume: 43, Issue:4, 2017

Ischaemic stroke and the recanalization drug tissue plasminogen activator interfere with antibacterial phagocyte function.
Journal of neuroinflammation, , 07-21, Volume: 14, Issue:1, 2017

Nanoliposome containing cyclosporine A reduced neuroinflammation responses and improved neurological activities in cerebral ischemia/reperfusion in rat.
Fundamental & clinical pharmacology, , Volume: 31, Issue:2, 2017

Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke.
Brain : a journal of neurology, , Oct-01, Volume: 140, Issue:10, 2017

Association of Osteopontin, Neopterin, and Myeloperoxidase With Stroke Risk in Patients With Prior Stroke or Transient Ischemic Attacks: Results of an Analysis of 13 Biomarkers From the Stroke Prevention by Aggressive Reduction in Cholesterol Levels Trial
Stroke, , Volume: 48, Issue:12, 2017

Inflammatory Biomarkers in Childhood Arterial Ischemic Stroke: Correlates of Stroke Cause and Recurrence.
Stroke, , Volume: 47, Issue:9, 2016

Myeloperoxidase Inhibition Increases Neurogenesis after Ischemic Stroke.
The Journal of pharmacology and experimental therapeutics, , Volume: 359, Issue:2, 2016

Dysfunctional HDL in acute stroke.
Atherosclerosis, , Volume: 253, 2016

Beyond Cholesterol - New Cardiovascular Biomarkers.
Nestle Nutrition Institute workshop series, , Volume: 84, 2016

Neuroinflammatory response to experimental stroke is inhibited by eriodictyol.
Behavioural brain research, , 10-01, Volume: 312, 2016

Platelets and Inflammatory Parameters Do Not Affect Long-Term Survival after Acute Stroke.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 25, Issue:8, 2016

The economic impact of implementing a multiple inflammatory biomarker-based approach to identify, treat, and reduce cardiovascular risk.
Journal of medical economics, , Volume: 18, Issue:7, 2015

Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 35, Issue:3, 2015

The Effect of Pre-Condition Cerebella Fastigial Nucleus Electrical Stimulation within and beyond the Time Window of Thrombolytic on Ischemic Stroke in the Rats.
PloS one, , Volume: 10, Issue:5, 2015

Serum myeloperoxidase levels in predicting the severity of stroke and mortality in acute ischemic stroke patients.
European review for medical and pharmacological sciences, , Volume: 19, Issue:11, 2015

[Case of CNS-limited ANCA-associated vasculitis presenting as recurrent ischemic stroke].
Rinsho shinkeigaku = Clinical neurology, , Volume: 54, Issue:5, 2014

Novel inflammatory biomarkers and their correlation to Chlamydia pneumoniae titres in acute ischemic stroke.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 23, Issue:9, 2014

Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study.
Innate immunity, , Volume: 20, Issue:5, 2014

The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke.
Neuropharmacology, , Volume: 81, 2014

Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice.
Clinics (Sao Paulo, Brazil), , Volume: 68, Issue:3, 2013

High-density lipoproteins limit neutrophil-induced damage to the blood-brain barrier in vitro.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 33, Issue:4, 2013

Serum levels of anti-apolipoprotein A-1 auto-antibodies and myeloperoxidase as predictors of major adverse cardiovascular events after carotid endarterectomy.
Thrombosis and haemostasis, , Volume: 109, Issue:4, 2013

Usefulness of cardiac biomarker score for risk stratification in stable patients undergoing elective cardiac evaluation across glycemic status.
The American journal of cardiology, , Feb-15, Volume: 111, Issue:4, 2013

Plasma myeloperoxidase predicts incident cardiovascular risks in stable patients undergoing medical management for coronary artery disease.
Clinical chemistry, , Volume: 57, Issue:1, 2011

Tropisetron ameliorates ischemic brain injury in an embolic model of stroke.
Brain research, , May-25, Volume: 1392, 2011

Variants in the inflammatory IL6 and MPO genes modulate stroke susceptibility through main effects and gene-gene interactions.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 31, Issue:8, 2011

Plasma myeloperoxidase levels in patients with acute ischemic stroke.
Romanian journal of internal medicine = Revue roumaine de medecine interne, , Volume: 48, Issue:1, 2010

Oxidative stress after thrombolysis-induced reperfusion in human stroke.
Stroke, , Volume: 41, Issue:4, 2010

Immunomodulatory effect of Hawthorn extract in an experimental stroke model.
Journal of neuroinflammation, , Dec-30, Volume: 7, 2010

Colonic bacterial translocation as a possible factor in stress-worsening experimental stroke outcome.
American journal of physiology. Regulatory, integrative and comparative physiology, , Volume: 296, Issue:4, 2009

Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke.
Stroke, , Volume: 39, Issue:4, 2008

Myeloperoxidase, but not C-reactive protein, predicts cardiovascular risk in peripheral arterial disease.
European heart journal, , Volume: 29, Issue:2, 2008

Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase.
Proceedings of the National Academy of Sciences of the United States of America, , Nov-25, Volume: 105, Issue:47, 2008

Hypothermia in acute stroke--slow versus fast rewarming an experimental study in rats.
Experimental neurology, , Volume: 204, Issue:1, 2007

Characterization of a rat model to study acute neuroinflammation on histopathological, biochemical and functional outcomes.
Journal of neuroscience methods, , Jun-15, Volume: 144, Issue:2, 2005

Matrix metalloproteinase-9 and myeloperoxidase expression: quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemia.
Stroke, , Volume: 35, Issue:5, 2004

Effects of a selective CD11b/CD18 antagonist and recombinant human tissue plasminogen activator treatment alone and in combination in a rat embolic model of stroke.
Stroke, , Volume: 34, Issue:7, 2003

Myeloperoxidase polymorphisms in brain infarction. Association with infarct size and functional outcome.
Atherosclerosis, , Volume: 167, Issue:2, 2003

Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody: a bedside-to-bench study.
Stroke, , Volume: 32, Issue:11, 2001

[Characteristics of some links of the antioxidant system in patients with complicated cerebral stroke].
Likars'ka sprava, , Issue:1

Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats.
Molecular medicine (Cambridge, Mass.), , Volume: 17, Issue:9-10

[Application of flow cytometry in the differential diagnosis of lymphoma/leukemia with aberrant antigen expression].
Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 33, Issue:6, 2004

Catalyzed signal amplification for cyclin D1 detection in mantle cell lymphoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, , Volume: 16, Issue:2, 2003

Inhibition of myeloperoxidase by N-acetyl lysyltyrosylcysteine amide reduces experimental autoimmune encephalomyelitis-induced injury and promotes oligodendrocyte regeneration and neurogenesis in a murine model of progressive multiple sclerosis.
Neuroreport, , 02-07, Volume: 29, Issue:3, 2018

Fetal Growth Restriction Induced by Transient Uterine Ischemia-Reperfusion: Differential Responses in Different Mouse Strains.
Reproductive sciences (Thousand Oaks, Calif.), , Volume: 25, Issue:7, 2018

Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats.
Naunyn-Schmiedeberg's archives of pharmacology, , Volume: 389, Issue:12, 2016

Impact of toll-like receptor 4 deficiency on the response to uterine ischemia/reperfusion in mice.
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Thiol and hydrogen peroxide modification of recA induction in UV-irradiated wild-type and catalase-deficient Escherichia coli K12.
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Hematology/oncology clinics of North America, , Volume: 2, Issue:2, 1988

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Gut, , Volume: 53, Issue:12, 2004

Visceral hypersensitivity and altered colonic motility after subsidence of inflammation in a rat model of colitis.
World journal of gastroenterology, , Volume: 9, Issue:12, 2003

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Association between nutritional, inflammatory and oxidative status (NIOS) and risk of adverse outcomes in patients on haemodialysis (HD): the NIOS-HD prospective cohort study protocol.
BMJ open, , 09-20, Volume: 12, Issue:9, 2022

Causal Pathways from Enteropathogens to Environmental Enteropathy: Findings from the MAL-ED Birth Cohort Study.
EBioMedicine, , Volume: 18, 2017

A methodologic framework for modeling and assessing biomarkers of environmental enteropathy as predictors of growth in infants: an example from a Peruvian birth cohort.
The American journal of clinical nutrition, , Volume: 106, Issue:1, 2017

Preoperative vitamin C supplementation improves colorectal anastomotic healing and biochemical parameters in malnourished rats.
International journal of colorectal disease, , Volume: 31, Issue:11, 2016

Protein- and zinc-deficient diets modulate the murine microbiome and metabolic phenotype.
The American journal of clinical nutrition, , Volume: 104, Issue:5, 2016

Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants.
The American journal of tropical medicine and hygiene, , Volume: 88, Issue:2, 2013

Serum myeloperoxidase and mortality in maintenance hemodialysis patients.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 48, Issue:1, 2006

Myeloperoxidase as a biomarker for intestinal-brain axis dysfunction induced by malnutrition and Cryptosporidium infection in weanling mice.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, , Volume: 27, Issue:3

Noma-like gangrenous cheilitis in a child with cyclic neutropenia associated with myeloperoxidase deficiency.
Pediatric dermatology, , Volume: 20, Issue:6

Effects of Obesity on Pulmonary Inflammation and Remodeling in Experimental Moderate Acute Lung Injury.
Frontiers in immunology, , Volume: 10, 2019

ANCA-associated vasculitis in scleroderma: A renal perspective .
Clinical nephrology, , Volume: 90, Issue:6, 2018

Salivary: flow and proteins of the innate and adaptive immunity in the limited and diffused systemic sclerosis.
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A patient with diffuse cutaneous systemic sclerosis complicated by antineutrophil-cytoplasmic antibody-associated vasculitis exhibiting honeycomb lung without volume loss.
Internal medicine (Tokyo, Japan), , Volume: 53, Issue:7, 2014

ANCA-related crescentic glomerulonephritis in systemic sclerosis: revisiting the "normotensive scleroderma renal crisis".
Clinical nephrology, , Volume: 68, Issue:3, 2007

Myeloperoxidase-antineutrophil cytoplasmic antibody seroconversion and fulminant vasculitis in Scl-70-positive scleroderma.
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Salivary: flow and proteins of the innate and adaptive immunity in the limited and diffused systemic sclerosis.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, , Volume: 43, Issue:7, 2014

Myeloperoxidase in Hypertensive Disorders of Pregnancy and Its Relation With Nitric Oxide.
Hypertension (Dallas, Tex. : 1979), , Volume: 69, Issue:6, 2017

Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats.
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Comparison of Diabetic and Non-diabetic Human Leukocytic Responses to Different Capsule Types of
Frontiers in cellular and infection microbiology, , Volume: 7, 2017

Fecal eosinophil cationic protein as a marker of active disease and treatment outcome in collagenous colitis: a pilot study.
Scandinavian journal of gastroenterology, , Volume: 46, Issue:7-8, 2011

Steroids reduce local inflammatory mediator secretion and mucosal permeability in collagenous colitis patients.
World journal of gastroenterology, , Nov-21, Volume: 12, Issue:43, 2006

Detection of inflammatory markers in stools from patients with irritable bowel syndrome and collagenous colitis.
Scandinavian journal of gastroenterology, , Volume: 41, Issue:1, 2006

Extramedullary haematopoiesis in massive hepatic necrosis.
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Repeated exposure to intra-amniotic LPS partially protects against adverse effects of intravenous LPS in preterm lambs.
Innate immunity, , Volume: 20, Issue:2, 2014

Umbilical cord serum interleukin-6, C-reactive protein, and myeloperoxidase concentrations at birth and association with neonatal morbidities and long-term neurodevelopmental outcomes.
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Amniotic fluid myeloperoxidase in pregnancies complicated by preterm prelabor rupture of membranes.
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Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs.
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Association of the NQO1, MPO, and XRCC1 polymorphisms and chromosome damage among workers at a petroleum refinery.
Journal of toxicology and environmental health. Part A, , Volume: 71, Issue:5, 2008

Biomass growth, micronucleus induction, and antioxidant stress enzyme responses in Vicia faba exposed to cadmium in solution.
Environmental toxicology and chemistry, , Volume: 22, Issue:3, 2003

Combined effects of PLGA and vascular endothelial growth factor promote the healing of non-diabetic and diabetic wounds.
Nanomedicine : nanotechnology, biology, and medicine, , Volume: 11, Issue:8, 2015

Myeloperoxidase levels predict accelerated progression of coronary atherosclerosis in diabetic patients: insights from intravascular ultrasound.
Atherosclerosis, , Volume: 232, Issue:2, 2014

Gender-specific correlation between plasma myeloperoxidase levels and serum high-density lipoprotein-associated paraoxonase-1 levels in patients with stable and unstable coronary artery disease.
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Positive association between plasma levels of oxidized low-density lipoprotein and myeloperoxidase after hemodialysis in patients with diabetic end-stage renal disease.
Hemodialysis international. International Symposium on Home Hemodialysis, , Volume: 17, Issue:4, 2013

Protein oxidation in chronic kidney disease.
Clinical hemorheology and microcirculation, , Volume: 54, Issue:4, 2013

[Diabetes mellitus ulcers treatment with Bletilla striata polysaccharide].
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[ANCA-related glomerulonephritis in an aged patient with diabetes mellitus successfully released from hemodialysis by low dose steroid therapy: a case report].
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Effect of diabetes mellitus on acinar morphology, peroxidase concentration, and release in isolated rat lacrimal glands.
Current eye research, , Volume: 34, Issue:10, 2009

Effect of diode laser on enzymatic activity of parotid glands of diabetic rats.
Lasers in medical science, , Volume: 24, Issue:4, 2009

Mass spectrometric quantification of amino acid oxidation products identifies oxidative mechanisms of diabetic end-organ damage.
Reviews in endocrine & metabolic disorders, , Volume: 9, Issue:4, 2008

Relationship of flow rate, uric acid, peroxidase, and superoxide dismutase activity levels with complications in diabetic patients: can saliva be used to diagnose diabetes?
Antioxidants & redox signaling, , Volume: 9, Issue:6, 2007

SLE and rapidly progressive glomerulonephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 45, Issue:5, 2005

[Fungal pyomyositis in a diabetic patient as manifestation of myeloperoxidase deficit].
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Leukocyte myeloperoxidase deficiency and diabetes mellitus associated with Candida albicans liver abscess.
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Schweizerische medizinische Wochenschrift, , Oct-15, Volume: 107, Issue:41, 1977

[Increased myelopepoxidase activity is a risk factor for ishemic heart disease in patients with diabetes mellitus].
Biomeditsinskaia khimiia, , Volume: 58, Issue:4

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Thyroid autoimmunity: is really associated with papillary thyroid carcinoma?
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Cerebellopathy secondary to anti-peroxidase antibody-mediated toxicity. A special case of Hashimoto encephalopathy.
Journal of neuroimmunology, , 11-15, Volume: 312, 2017

[Distribution of IgG subclasses of TgAb and TPOAb in sera from patients with Graves' disease, Graves' disease plus Hashimoto's thyroiditis and Hashimoto's thyrotoxicosis].
Zhonghua yi xue za zhi, , Jan-14, Volume: 94, Issue:2, 2014

Serum negative autoimmune thyroiditis displays a milder clinical picture compared with classic Hashimoto's thyroiditis.
European journal of endocrinology, , Volume: 171, Issue:1, 2014

Hashimoto's thyroiditis as a risk factor of papillary thyroid cancer may improve cancer prognosis.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, , Volume: 148, Issue:3, 2013

Opsoclonus as a manifestation of Hashimoto's encephalopathy.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 19, Issue:10, 2012

[A case of MPO-ANCA-related microscopic polyangiitis with mixed cryoglobulinemia].
Nihon Jinzo Gakkai shi, , Volume: 48, Issue:4, 2006

Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides.
Arthritis research & therapy, , Volume: 7, Issue:5, 2005

Cryoglobulins and multispecific antineutrophil cytoplasmic antibodies in propylthiouracil-induced necrotizing cutaneous vasculitis--a new association.
European journal of dermatology : EJD, , Volume: 22, Issue:5

Plasma Concentrations of New Biochemical Markers of Atherosclerosis in Patients with Dyslipidemia-A Pilot Study.
Medicina (Kaunas, Lithuania), , May-27, Volume: 58, Issue:6, 2022

ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL inhibition in mastitis mice.
Experimental and molecular pathology, , Volume: 103, Issue:3, 2017

Long-term follow-up of circulating oxidative stress markers in patients undergoing lipoprotein apheresis by Direct Adsorption of Lipids (DALI).
Atherosclerosis. Supplements, , Volume: 30, 2017

Role of Myeloperoxidase in Patients with Chronic Kidney Disease.
Oxidative medicine and cellular longevity, , Volume: 2016, 2016

Caryocar coriaceum Wittm. (Pequi) fixed oil presents hypolipemic and anti-inflammatory effects in vivo and in vitro.
Journal of ethnopharmacology, , Sep-15, Volume: 191, 2016

A low-frequency variant in MAPK14 provides mechanistic evidence of a link with myeloperoxidase: a prognostic cardiovascular risk marker.
Journal of the American Heart Association, , Aug-27, Volume: 3, Issue:4, 2014

Leukocyte and leukocyte subset counts reveal compensatory mechanisms in coronary heart disease.
Clinica chimica acta; international journal of clinical chemistry, , Mar-15, Volume: 418, 2013

Serum Fetuin-A levels, insulin resistance and oxidative stress in women with polycystic ovary syndrome.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, , Volume: 29, Issue:12, 2013

Myeloperoxidase overexpression in children with hypercholesterolemia.
Atherosclerosis, , Volume: 205, Issue:1, 2009

Dysfunctional high-density lipoprotein.
Current opinion in endocrinology, diabetes, and obesity, , Volume: 16, Issue:2, 2009

Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects.
Molecular biology reports, , Volume: 45, Issue:5, 2018

Myeloperoxidase-positive cell infiltration of normal colorectal mucosa is related to body fatness and is predictive of adenoma occurrence.
International journal of obesity (2005), , Volume: 41, Issue:6, 2017

Paraoxonase-1 and myeloperoxidase correlate with vascular biomarkers in overweight patients with newly diagnosed untreated hyperlipidaemia.
VASA. Zeitschrift fur Gefasskrankheiten, , Volume: 46, Issue:5, 2017

Paraoxonase-1 arylesterase activity is an independent predictor of myeloperoxidase levels in overweight patients with or without cardiovascular complications.
Clinical biochemistry, , Volume: 49, Issue:12, 2016

Association of myeloperoxidase levels with cardiometabolic factors and renal function in prepubertal children.
European journal of clinical investigation, , Volume: 46, Issue:1, 2016

Aerobic training suppresses exercise-induced lipid peroxidation and inflammation in overweight/obese adolescent girls.
Pediatric exercise science, , Volume: 27, Issue:1, 2015

Internet-delivered lifestyle physical activity intervention: limited inflammation and antioxidant capacity efficacy in overweight adults.
Journal of applied physiology (Bethesda, Md. : 1985), , Volume: 106, Issue:1, 2009

Effect of a short-term diet and exercise intervention in youth on atherosclerotic risk factors.
Atherosclerosis, , Volume: 191, Issue:1, 2007

Fraxetin prevented sodium fluoride-induced chronic pancreatitis in rats: Role of anti-inflammatory, antioxidant, antifibrotic and anti-apoptotic activities.
International immunopharmacology, , Volume: 93, 2021

Fibroblast growth factor 21 ameliorates pancreatic fibrogenesis via regulating polarization of macrophages.
Experimental cell research, , 09-01, Volume: 382, Issue:1, 2019

[The role of oxidative inflammatory cascade on pancreatic fibrosis progression in mice induced by DBTC plus ethanol].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, , Volume: 31, Issue:5, 2015

Effect of thymoquinone on ethanol and high fat diet induced chronic pancreatitis--a dose response study in rats.
Indian journal of experimental biology, , Volume: 51, Issue:4, 2013

TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis.
The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-27, Volume: 33, Issue:13, 2013

Exenatide-induced chronic damage of pancreatic tissue in rats.
Pancreas, , Volume: 41, Issue:8, 2012

Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor.
Pancreas, , Volume: 39, Issue:1, 2010

FTY720, an immunosuppressant, attenuates chronic pancreatitis in rats by suppressing T-cell infiltration.
Pancreas, , Volume: 30, Issue:3, 2005

Cumulative effects of bone and soft tissue injury on systemic inflammation: a pilot study.
Clinical orthopaedics and related research, , Volume: 471, Issue:9, 2013

Salivary changes in oxidative stress related to inflammation in oral and gastrointestinal diseases.
Oral diseases, , Volume: 27, Issue:2, 2021

A patient with intravascular lymphoma presenting with cerebral infarction and a high serum MPO-ANCA level.
Modern rheumatology, , Volume: 21, Issue:2, 2011

Diffuse alveolar haemorrhage associated with subsequent development of ANCA positivity and emphysema in three young adults.
BMC pulmonary medicine, , Oct-24, Volume: 19, Issue:1, 2019

An Elderly Man with Fatigue, Dyspnea, and Kidney Failure.
Clinical journal of the American Society of Nephrology : CJASN, , 05-08, Volume: 12, Issue:5, 2017

Successful Management of Lupus Nephritis with High Titers of Myeloperoxidase Anti-Neutrophil Cytoplasmic Antibodies Using Tacrolimus.
Internal medicine (Tokyo, Japan), , Volume: 54, Issue:22, 2015

Chronic pulmonary bleeding as the first sign of microscopic polyangiitis associated with autoimmune thyroiditis.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, , Volume: 31, Issue:4, 2011

Mesenteric lymph duct ligation against renal injury in rats after hemorrhagic shock.
Renal failure, , Volume: 32, Issue:5, 2010

Interstitial Foxp3-positive T cells may predict renal survival in patients with myeroperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.
Clinical and experimental pharmacology & physiology, , Volume: 37, Issue:9, 2010

Remote renal injury following partial hepatic ischemia/reperfusion injury in rats.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, , Volume: 12, Issue:3, 2008

Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis in scleroderma--a different kind of renal crisis.
The Journal of rheumatology, , Volume: 33, Issue:9, 2006

Systemic cholesterol embolization syndrome associated with myeloperoxidase-anti-neutrophil cytoplasmic antibody.
Internal medicine (Tokyo, Japan), , Volume: 45, Issue:8, 2006

The effects of ginkgo biloba extract on tissue adenosine deaminase, xanthine oxidase, myeloperoxidase, malondialdehyde, and nitric oxide in cisplatin-induced nephrotoxicity.
Toxicology and industrial health, , Volume: 22, Issue:3, 2006

Peroxisome proliferator-activated receptor beta/delta exerts a strong protection from ischemic acute renal failure.
Journal of the American Society of Nephrology : JASN, , Volume: 16, Issue:8, 2005

Primed peripheral polymorphonuclear leukocyte: a culprit underlying chronic low-grade inflammation and systemic oxidative stress in chronic kidney disease.
Journal of the American Society of Nephrology : JASN, , Volume: 16, Issue:8, 2005

[Clinical and pathological characterization of antineutrophil cytoplasmic antibody associated small vasculitis in children].
Zhonghua er ke za zhi = Chinese journal of pediatrics, , Volume: 42, Issue:6, 2004

Biochemical and spectrophotometric significance of advanced oxidized protein products.
Biochimica et biophysica acta, , Jun-28, Volume: 1689, Issue:2, 2004

The significance of antineutrophil cytoplasmic antibody in microscopic polyangitis and classic polyarteritis nodosa.
Archives of disease in childhood, , Volume: 85, Issue:5, 2001

Myeloperoxidase-catalyzed 3-chlorotyrosine formation in dialysis patients.
Free radical biology & medicine, , Nov-15, Volume: 31, Issue:10, 2001

Effect of N-acetylcysteine on gentamicin-mediated nephropathy in rats.
European journal of pharmacology, , Jul-13, Volume: 424, Issue:1, 2001

MPO-ANCA-Positive crescentic glomerulonephritis: a distinct entity of scleroderma renal disease?
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 33, Issue:4, 1999

Sensitive enzymatic assay for erythrocyte creatine with production of methylene blue.
Clinical chemistry, , Volume: 44, Issue:7, 1998

Scleroderma, D-penicillamine treatment, and progressive renal failure associated with positive antimyeloperoxidase antineutrophil cytoplasmic antibodies.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 30, Issue:2, 1997

Thiazide-induced kidney damage with circulating antibodies against myeloperoxidase and cardiolipin.
Journal of internal medicine, , Volume: 233, Issue:6, 1993

[Progressive systemic sclerosis associated with anti-myeloperoxidase ANCA vasculitis with renal and cutaneous involvement].
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, , Volume: 20, Issue:4

The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study.
International braz j urol : official journal of the Brazilian Society of Urology, , Volume: 43, Issue:2

Manifest interstitial and vascular pathology in anti-neutrophil cytoplasmic antibody-associated renal disease.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, , Volume: 30, Issue:3

Recipient myeloperoxidase-producing cells regulate antibody-mediated acute versus chronic kidney allograft rejection.
JCI insight, , 07-08, Volume: 6, Issue:13, 2021

High-density lipoprotein metabolism, composition, function, and deficiency.
Current opinion in lipidology, , Volume: 25, Issue:3, 2014

Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody-associated vasculitis.
Rheumatology (Oxford, England), , 11-01, Volume: 56, Issue:11, 2017

Systemic inflammation in the extremely low gestational age newborn following maternal genitourinary infections.
American journal of reproductive immunology (New York, N.Y. : 1989), , Volume: 73, Issue:2, 2015

Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody-associated vasculitis.
Rheumatology (Oxford, England), , 11-01, Volume: 56, Issue:11, 2017

Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation.
Fertility and sterility, , Volume: 73, Issue:3, 2000

Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion.
The Journal of surgical research, , Volume: 155, Issue:2, 2009

Lung injury and recovery in a murine model of unilateral acid aspiration: functional, biochemical, and morphologic characterization.
Anesthesiology, , Volume: 108, Issue:6, 2008

Neutrophil extracellular traps (NETs) are increased in the alveolar spaces of patients with ventilator-associated pneumonia.
Critical care (London, England), , 12-27, Volume: 22, Issue:1, 2018

Early increase of VEGF-A is associated with resolution of ventilator-associated pneumonia: Clinical and experimental evidence.
Respirology (Carlton, Vic.), , Volume: 23, Issue:10, 2018

Acute ST elevation myocardial infarction in fulminant systemic p-ANCA vasculitis: a rare catastrophic complication.
BMJ case reports, , Jun-29, Volume: 2016, 2016

Preventive effect of yuzu and hesperidin on left ventricular remodeling and dysfunction in rat permanent left anterior descending coronary artery occlusion model.
PloS one, , Volume: 10, Issue:1, 2015

Sophocarpine administration preserves myocardial function from ischemia-reperfusion in rats via NF-κB inactivation.
Journal of ethnopharmacology, , Jun-01, Volume: 135, Issue:3, 2011

A case of MPO-ANCA-positive cutaneous polyarteritis nodosa with livedo racemosa arising from immune-deposit-positive necrotizing vasculitis.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, , Volume: 155, Issue:3, 2020

Neutrophil degranulation biomarkers characterize restrictive echocardiographic pattern with diastolic dysfunction in patients with diabetes.
European journal of clinical investigation, , Volume: 51, Issue:12, 2021

Integrating plasma high-sensitivity C-reactive protein and myeloperoxidase for risk prediction in chronic systolic heart failure.
Congestive heart failure (Greenwich, Conn.), , Volume: 17, Issue:3

Neutrophil degranulation biomarkers characterize restrictive echocardiographic pattern with diastolic dysfunction in patients with diabetes.
European journal of clinical investigation, , Volume: 51, Issue:12, 2021

Myeloperoxidase, a possible biomarker for the early diagnosis of cardiac diastolic dysfunction with preserved ejection fraction.
Journal of enzyme inhibition and medicinal chemistry, , Volume: 33, Issue:1, 2018

Pathways of Neutrophil Granulocyte Activation in Hereditary Angioedema with C1 Inhibitor Deficiency.
Clinical reviews in allergy & immunology, , Volume: 60, Issue:3, 2021

Early T-cell precursor acute lymphoblastic leukemia with Auer rods-A case report.
International journal of laboratory hematology, , Volume: 42, Issue:1, 2020

[Value of CD, MPO, Ki-67 and C-MYC Positive Rate in the Pathological Tissues and C-MYC Gene of Patients with T-LBL/ALL for Predicting Prognosis].
Zhongguo shi yan xue ye xue za zhi, , Volume: 26, Issue:1, 2018

Lymphoblastic lymphoma with unusual cytological features in pericardial effusion fluid.
Cytopathology : official journal of the British Society for Clinical Cytology, , Volume: 23, Issue:1, 2012

CD117 expression is a sensitive but nonspecific predictor of FLT3 mutation in T acute lymphoblastic leukemia and T/myeloid acute leukemia.
American journal of clinical pathology, , Volume: 137, Issue:2, 2012

Immunophenotypic analysis of myeloperoxidase-negative leukemia cutis and blastic plasmacytoid dendritic cell neoplasm.
American journal of clinical pathology, , Volume: 137, Issue:3, 2012

Cardioprotective Effects of Nicorandil on Coronary Heart Disease Patients Undergoing Elective Percutaneous Coronary Intervention.
Medical science monitor : international medical journal of experimental and clinical research, , Jun-15, Volume: 23, 2017

Growth differentiation factor 15 may protect the myocardium from no‑reflow by inhibiting the inflammatory‑like response that predominantly involves neutrophil infiltration.
Molecular medicine reports, , Volume: 13, Issue:1, 2016

No-reflow reversibility: a study based on serial assessment of multiple biomarkers.
Journal of cardiovascular translational research, , Volume: 6, Issue:5, 2013

Myeloid sarcoma of the orbit without systemic recurrence of disease in an adult: A clinicopathological case report.
Orbit (Amsterdam, Netherlands), , Volume: 35, Issue:2, 2016

Serglycin proteoglycan in hematologic malignancies: a marker of acute myeloid leukemia.
Leukemia, , Volume: 21, Issue:12, 2007

Rapid aortic and mitral valve thickening and regurgitation with complete atrioventricular block due to myeloperoxidase anti-neutrophil cytoplasmic antibody-associated vasculitis.
Journal of echocardiography, , Volume: 19, Issue:3, 2021

Incidence and risk factors of venous thromboembolism in ANCA-associated vasculitis: a metaanalysis and metaregression.
Clinical rheumatology, , Volume: 40, Issue:7, 2021

Association of Pulmonary Hemorrhage, Positive Proteinase 3, and Urinary Red Blood Cell Casts With Venous Thromboembolism in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Arthritis & rheumatology (Hoboken, N.J.), , Volume: 71, Issue:11, 2019

Histological criteria for age determination of fatal venous thromboembolism.
International journal of legal medicine, , Volume: 132, Issue:3, 2018

Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development.
Journal of thrombosis and haemostasis : JTH, , Volume: 12, Issue:6, 2014

Inflammation and thrombo-occlusive vessel signalling in benign atrophic papulosis (Köhlmeier-Degos disease).
Journal of the European Academy of Dermatology and Venereology : JEADV, , Volume: 36, Issue:11, 2022

MPO-ANCA-positive conversion and microscopic polyangiitis development in idiopathic interstitial pneumonia: a case report.
CEN case reports, , Volume: 12, Issue:1, 2023

Clinical significance of myeloperoxidase-anti-neutrophil cytoplasmic antibody in idiopathic interstitial pneumonias.
PloS one, , Volume: 13, Issue:6, 2018

Two types of myeloperoxidase-antineutrophil cytoplasmic autoantibodies with a high affinity and a low affinity in small vessel vasculitis.
Clinical and experimental rheumatology, , Volume: 27, Issue:1 Suppl 52

Risk of progression of idiopathic pulmonary fibrosis to connective tissue disease: a long-term observational study in 527 patients.
Clinical rheumatology, , Volume: 40, Issue:6, 2021

Antineutrophil cytoplasmic antibody-associated interstitial lung disease: a review.
European respiratory review : an official journal of the European Respiratory Society, , Dec-31, Volume: 30, Issue:162, 2021

Prognostic value of radiological findings indeterminate for UIP pattern and anterior upper lobe honeycomb-like lesion in chronic fibrosing interstitial lung disease associated with MPO-ANCA.
BMC pulmonary medicine, , Nov-03, Volume: 21, Issue:1, 2021

Relationship Between Combination of Pulmonary Fibrosis and Emphysema, ANCA, and Vasculitis.
Chest, , Volume: 158, Issue:3, 2020

Prevalence and Clinical Significance of Antineutrophil Cytoplasmic Antibodies in North American Patients With Idiopathic Pulmonary Fibrosis.
Chest, , Volume: 156, Issue:4, 2019

Systematic review and meta-analysis of clinical significance of autoantibodies for idiopathic pulmonary fibrosis.
BMJ open, , 05-29, Volume: 9, Issue:5, 2019

Prognosis of pulmonary fibrosis presenting with a usual interstitial pneumonia pattern on computed tomography in patients with myeloperoxidase anti-neutrophil cytoplasmic antibody-related nephritis: a retrospective single-center study.
BMC pulmonary medicine, , Nov-01, Volume: 19, Issue:1, 2019

From fibrosis to diagnosis: a paediatric case of microscopic polyangiitis and review of the literature.
Rheumatology international, , Volume: 38, Issue:4, 2018

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017

Clinical features of usual interstitial pneumonia with anti-neutrophil cytoplasmic antibody in comparison with idiopathic pulmonary fibrosis.
Respirology (Carlton, Vic.), , Volume: 21, Issue:5, 2016

Prevalence and Responsiveness to Treatment of Lung Abnormalities on Chest Computed Tomography in Patients With Microscopic Polyangiitis: A Multicenter, Longitudinal, Retrospective Study of One Hundred Fifty Consecutive Hospital-Based Japanese Patients.
Arthritis & rheumatology (Hoboken, N.J.), , Volume: 68, Issue:3, 2016

Idiopathic lung fibrosis and anti myeloperoxidase glomerulonephritis: the tree that hides the forest.
BMC pulmonary medicine, , Oct-26, Volume: 15, 2015

Amelioration of bleomycin-induced pulmonary fibrosis in a mouse model by a combination therapy of bosentan and imatinib.
Experimental lung research, , Volume: 41, Issue:4, 2015

Incidence of myeloperoxidase anti-neutrophil cytoplasmic antibody positivity and microscopic polyangitis in the course of idiopathic pulmonary fibrosis.
Respiratory medicine, , Volume: 107, Issue:4, 2013

Heterogeneity of chronic lung allograft dysfunction: insights from protein expression in broncho alveolar lavage.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, , Volume: 30, Issue:6, 2011

Coll2-1, Coll2-1NO2 and myeloperoxidase concentrations in the synovial fluid of equine tarsocrural joints affected with osteochondrosis.
Veterinary research communications, , Volume: 35, Issue:7, 2011

Relationship between arthroscopic joint evaluation and the levels of Coll2-1, Coll2-1NO(2), and myeloperoxidase in the blood and synovial fluid of horses affected with osteochondrosis of the tarsocrural joint.
Osteoarthritis and cartilage, , Volume: 19, Issue:11, 2011

Subglottic stenosis and endobronchial disease in granulomatosis with polyangiitis.
Rheumatology (Oxford, England), , 12-01, Volume: 58, Issue:12, 2019

Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial.
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International journal of dental hygiene, , Volume: 15, Issue:1, 2017

Statins and IL-1β, IL-10, and MPO Levels in Gingival Crevicular Fluid: Preliminary Results.
Inflammation, , Volume: 39, Issue:4, 2016

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PloS one, , Volume: 10, Issue:7, 2015

S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation.
BMC oral health, , Aug-07, Volume: 15, 2015

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Inflammation, , Volume: 37, Issue:5, 2014

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Matrix metalloproteinases and myeloperoxidase in gingival crevicular fluid provide site-specific diagnostic value for chronic periodontitis.
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Genetic variation of myeloperoxidase gene contributes to aggressive periodontitis: a preliminary association study in Turkish population.
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Gingival crevicular fluid levels of MMP-8, MMP-9, TIMP-2, and MPO decrease after periodontal therapy.
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Nutritional intervention in patients with periodontal disease: clinical, immunological and microbiological variables during 12 months.
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Moxifloxacin as an adjunctive antibiotic in the treatment of severe chronic periodontitis.
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The effect of non-surgical periodontal therapy on peroxidase activity in diabetic patients: a case-control pilot study.
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The effect of smoking on gingival crevicular fluid levels of myeloperoxidase.
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Mimicking the mimicker: Necrotizing sarcoid granulomatosis.
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Pulmonary manifestations and outcomes in paediatric ANCA-associated vasculitis: a single-centre experience.
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[A case of MPO-ANCA positive vasculitis associated with multiple pulmonary nodules following propylthiouracil treatment].
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
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Therapeutic inhibition of MPO stabilizes pre-existing high risk atherosclerotic plaque.
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High Plasma Myeloperoxidase Is Associated with Plaque Erosion in Patients with ST-Segment Elevation Myocardial Infarction.
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Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition.
PloS one, , Volume: 14, Issue:3, 2019

Sodium thiocyanate treatment attenuates atherosclerotic plaque formation and improves endothelial regeneration in mice.
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Targeting myeloperoxidase in inflammatory atherosclerosis.
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Myeloperoxidase-catalyzed oxidation of cyanide to cyanate: A potential carbamylation route involved in the formation of atherosclerotic plaques?
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Neutrophil Extracellular Traps Participate in All Different Types of Thrombotic and Haemorrhagic Complications of Coronary Atherosclerosis.
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Myeloperoxidase is a potential molecular imaging and therapeutic target for the identification and stabilization of high-risk atherosclerotic plaque.
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Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndrome patients.
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Local Matrix Metalloproteinase 9 Level Determines Early Clinical Presentation of ST-Segment-Elevation Myocardial Infarction.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 36, Issue:12, 2016

Myeloperoxidase-mediated Methionine Oxidation Promotes an Amyloidogenic Outcome for Apolipoprotein A-I.
The Journal of biological chemistry, , Apr-24, Volume: 290, Issue:17, 2015

Thiocyanate supplementation decreases atherosclerotic plaque in mice expressing human myeloperoxidase.
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An abundant dysfunctional apolipoprotein A1 in human atheroma.
Nature medicine, , Volume: 20, Issue:2, 2014

Myeloperoxidase levels predict accelerated progression of coronary atherosclerosis in diabetic patients: insights from intravascular ultrasound.
Atherosclerosis, , Volume: 232, Issue:2, 2014

Extracellular traps in lipid-rich lesions of carotid atherosclerotic plaques: implications for lipoprotein retention and lesion progression.
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Biomarkers of plaque instability.
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Myeloperoxidase oxidized LDL interferes with endothelial cell motility through miR-22 and heme oxygenase 1 induction: possible involvement in reendothelialization of vascular injuries.
Mediators of inflammation, , Volume: 2014, 2014

Myeloperoxidase in cardiovascular disease.
Advances in clinical chemistry, , Volume: 62, 2013

Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex.
The Journal of clinical investigation, , Volume: 123, Issue:9, 2013

Association of biomarkers of lipid modification with functional and morphological indices of coronary stenosis severity in stable coronary artery disease.
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Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension.
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Liberation of vessel-adherent myeloperoxidase reflects plaque burden in patients with stable coronary artery disease.
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Polymorphonuclear neutrophils and instability of the atherosclerotic plaque: a causative role?
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Circulation, , Jul-26, Volume: 124, Issue:4, 2011

High levels of systemic myeloperoxidase are associated with coronary plaque erosion in patients with acute coronary syndromes: a clinicopathological study.
Circulation, , Dec-14, Volume: 122, Issue:24, 2010

Myeloperoxidase may help to differentiate coronary plaque erosion from plaque rupture in patients with acute coronary syndromes.
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Potential clinical utility of macrophage colony-stimulating factor, monocyte chemotactic protein-1 and myeloperoxidase in predicting atherosclerotic plaque instability.
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Elevated Systemic Levels of Eosinophil, Neutrophil, and Mast Cell Granular Proteins in
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Gut microbes, , Volume: 13, Issue:1

Sodium thiocyanate treatment attenuates atherosclerotic plaque formation and improves endothelial regeneration in mice.
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Neutrophil-derived myeloperoxidase promotes atherogenesis and neointima formation in mice.
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Prognostic value of myeloperoxidase in patients with peripheral artery disease.
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Plasma myeloperoxidase level and peripheral arterial disease.
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Precancerous ACF induction affects their regional distribution forsaking oxidative stress implication in 1,2-dimethylhydrazine-induced colon carcinogenesis model.
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Extracellular calcium-sensing receptor/PTH knockout mice colons have increased Wnt/β-catenin signaling, reduced non-canonical Wnt signaling, and increased susceptibility to azoxymethane-induced aberrant crypt foci.
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β-D-Glucan nanoparticle pre-treatment induce resistance against Pythium aphanidermatum infection in turmeric.
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Novel selective agonist of GPR18, PSB-KK-1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain.
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Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-
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The superoxide anion donor, potassium superoxide, induces pain and inflammation in mice through production of reactive oxygen species and cyclooxygenase-2.
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Riparin B, a Synthetic Compound Analogue of Riparin, Inhibits the Systemic Inflammatory Response and Oxidative Stress in Mice.
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Physiology & behavior, , Feb-10, Volume: 125, 2014

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MicroRNA-146a-5p attenuates visceral hypersensitivity through targeting chemokine CCL8 in the spinal cord in a mouse model of colitis.
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Activation of colo-rectal high-threshold afferent nerves by Interleukin-2 is tetrodotoxin-sensitive and upregulated in a mouse model of chronic visceral hypersensitivity.
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Minocycline ameliorates lung and liver dysfunction in a rodent model of hemorrhagic shock/resuscitation plus abdominal compartment syndrome.
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Lipopolysaccharide in systemic circulation induces activation of inflammatory response and oxidative stress in cardiorenal syndrome type 1.
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Detection of Neutrophils in the Sciatic Nerve Following Peripheral Nerve Injury.
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Serum S100A8 and S100A9 Enhance Innate Immune Responses in the Pathogenesis of Baker's Asthma.
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A case of MPO-ANCA-positive polyarteritis nodosa complicated by exudative otitis media, mononeuritis multiplex, and acute renal failure.
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Lower Urinary Tract Symptoms, Depression, Anxiety and Systemic Inflammatory Factors in Men: A Population-Based Cohort Study.
PloS one, , Volume: 10, Issue:10, 2015

Myeloperoxidase-dependent LDL modifications in bloodstream are mainly predicted by angiotensin II, adiponectin, and myeloperoxidase activity: a cross-sectional study in men.
Mediators of inflammation, , Volume: 2013, 2013

Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndrome patients.
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[Myeloperoxidase activity in blood plasma as a criterion of therapy for patients with cardiovascular disease].
Biomeditsinskaia khimiia, , Volume: 62, Issue:3, 2016

Local Matrix Metalloproteinase 9 Level Determines Early Clinical Presentation of ST-Segment-Elevation Myocardial Infarction.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 36, Issue:12, 2016

Long-term effect of molsidomine, a direct nitric oxide donor, as an add-on treatment, on endothelial dysfunction in patients with stable angina pectoris undergoing percutaneous coronary intervention: results of the MEDCOR trial.
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Polyunsaturated omega-3 fatty acids reduce lipoprotein-associated phospholipase A(2) in patients with stable angina.
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Gender-specific correlation between plasma myeloperoxidase levels and serum high-density lipoprotein-associated paraoxonase-1 levels in patients with stable and unstable coronary artery disease.
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Influenza Virus Infection Increases Host Susceptibility To Secondary Infection with Pseudomonas aeruginosa, and This Is Attributed To Neutrophil Dysfunction through Reduced Myeloperoxidase Activity.
Microbiology spectrum, , 02-14, Volume: 11, Issue:1, 2023

Myeloperoxidase and Other Markers of Neutrophil Activation Associate With Malaria and Malaria/HIV Coinfection in the Human Placenta.
Frontiers in immunology, , Volume: 12, 2021

Efferocytosis of Apoptotic Neutrophils Enhances Control of Mycobacterium tuberculosis in HIV-Coinfected Macrophages in a Myeloperoxidase-Dependent Manner.
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Neutrophil infiltration and activation in bronchiolitic airways are independent of viral etiology.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
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Nutrients, , Mar-28, Volume: 13, Issue:4, 2021

Lipoic Acid and Fish Oil Combination Potentiates Neuroinflammation and Oxidative Stress Regulation and Prevents Cognitive Decline of Rats After Sepsis.
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Peroxidase-Mimicking Nanoassembly Mitigates Lipopolysaccharide-Induced Endotoxemia and Cognitive Damage in the Brain by Impeding Inflammatory Signaling in Macrophages.
Nano letters, , 10-10, Volume: 18, Issue:10, 2018

Matrix metalloproteinase-9 is associated with acute inflammation after olfactory injury.
Neuroreport, , Aug-03, Volume: 22, Issue:11, 2011

Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Positive Otitis Media and Rhinosinusitis With Pathological Features of Immunoglobulin G4-Related Disease: A Case Report.
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An optimized, fast-to-perform mouse lung infection model with the human pathogen Chlamydia trachomatis for in vivo screening of antibiotics, vaccine candidates and modified host-pathogen interactions.
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An enzymatic method for erythrocyte acetylcholinesterase.
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Salivary immune proteins monitoring can help detection of binge and chronic alcohol drinkers: Preliminary findings.
Drug and alcohol dependence, , 02-01, Volume: 183, 2018

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Inhibitory Effects of Peroxidase from Foxtail Millet Bran on Colitis-Associated Colorectal Carcinogenesis by the Blockage of Glycerophospholipid Metabolism.
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Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter.
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Precancerous ACF induction affects their regional distribution forsaking oxidative stress implication in 1,2-dimethylhydrazine-induced colon carcinogenesis model.
Inflammopharmacology, , Volume: 26, Issue:2, 2018

Açaí Berries Inhibit Colon Tumorigenesis in Azoxymethane/Dextran Sulfate Sodium-Treated Mice.
Gut and liver, , Mar-15, Volume: 11, Issue:2, 2017

Role of the Vanins-Myeloperoxidase Axis in Colorectal Carcinogenesis.
International journal of molecular sciences, , Apr-27, Volume: 18, Issue:5, 2017

Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma.
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Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer.
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Intestinal and Limb Ischemic Preconditioning Provides a Combined Protective Effect in the Late Phase, But not in the Early Phase, Against Intestinal Injury Induced by Intestinal Ischemia-Reperfusion in Rats.
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Galectin-3 and Myeloperoxidase May Monitor Cancer-Therapy-Related Cardiotoxicity? A Systematic Review and Meta-Analysis.
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Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology.
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Protective Effects of Calpain Inhibition on Neurovascular Unit Injury through Downregulating Nuclear Factor-κB-related Inflammation during Traumatic Brain Injury in Mice.
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The Aedes aegypti peritrophic matrix controls arbovirus vector competence through HPx1, a heme-induced peroxidase.
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The expression of myeloperoxidase in thrombi is associated with reduced heme oxygenase-1 induction and worse left ventricular remodeling in patients with acute ST-elevation myocardial infarction.
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High Plasma Myeloperoxidase Is Associated with Plaque Erosion in Patients with ST-Segment Elevation Myocardial Infarction.
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Comparison of Ticagrelor with Clopidogrel in Reducing Interleukin-17 and Myeloperoxidase Expression in Thrombus and Improving Postprocedural Coronary Flow in ST-segment Elevation Myocardial Infarction Patients.
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Relation between high levels of myeloperoxidase in the culprit artery and microvascular obstruction, infarct size and reverse remodeling in ST-elevation myocardial infarction.
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Prognostic value of myeloperoxidase concentration in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention.
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Local Matrix Metalloproteinase 9 Level Determines Early Clinical Presentation of ST-Segment-Elevation Myocardial Infarction.
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Local Matrix Metalloproteinase 9 Level Determines Early Clinical Presentation of ST-Segment-Elevation Myocardial Infarction.
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Comparative Cardiac Safety of Selective Serotonin Reuptake Inhibitors among Individuals Receiving Maintenance Hemodialysis.
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A Multiple-Hit Hypothesis Involving Reactive Oxygen Species and Myeloperoxidase Explains Clinical Deterioration and Fatality in COVID-19.
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The association between immunoexpression levels of oxidant and antioxidant enzymes and lip squamous cell carcinoma.
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Binding of Intracellular Myeloperoxidase to αV/β1 Integrin Serves as a Mechanism of Survival in Epithelial Ovarian Cancer.
Reproductive sciences (Thousand Oaks, Calif.), , Volume: 30, Issue:1, 2023

Molecular Basis Supporting the Association of Talcum Powder Use With Increased Risk of Ovarian Cancer.
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Novel expression of CD11b in epithelial ovarian cancer: Potential therapeutic target.
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Thyroid autoimmunity: is really associated with papillary thyroid carcinoma?
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Hashimoto's thyroiditis as a risk factor of papillary thyroid cancer may improve cancer prognosis.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, , Volume: 148, Issue:3, 2013

Tracking significant modules and key genes for esophageal squamous cell carcinoma based on differential modules.
Journal of cancer research and therapeutics, , Volume: 14, Issue:Supplement, 2018

Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma.
Medical science monitor : international medical journal of experimental and clinical research, , Sep-07, Volume: 21, 2015

MPO-ANCA-positive granulomatosis with polyangiitis and concurrent IgG4-related disease with periaortitis and tubulointerstitial nephritis: A case report of a new overlap syndrome?
International journal of rheumatic diseases, , Volume: 26, Issue:9, 2023

Comment on: What is the meaning of ANCA positivity in IgG4-related disease?
Rheumatology (Oxford, England), , 09-01, Volume: 60, Issue:9, 2021

What is the meaning of ANCA positivity in IgG4-related disease?
Rheumatology (Oxford, England), , 08-02, Volume: 60, Issue:8, 2021

Vasculitic neuropathy associated with IgG4-related kidney disease: A case report and literature review.
Clinical nephrology, , Volume: 96, Issue:3, 2021

Clinical and pathological features of patients with antineutrophil cytoplasmic antibody-associated vasculitides concomitant with IgG4-related disease.
International journal of rheumatic diseases, , Volume: 22, Issue:12, 2019

A testis-expressing heme peroxidase HPX12 regulates male fertility in the mosquito Anopheles stephensi.
Scientific reports, , 02-16, Volume: 12, Issue:1, 2022

The JAK inhibitor ruxolitinib abrogates immune hepatitis instigated by concanavalin A in mice.
International immunopharmacology, , Volume: 103, 2022

Melatonin interferes with COVID-19 at several distinct ROS-related steps.
Journal of inorganic biochemistry, , Volume: 223, 2021

Neutrophil Extracellular Traps (NETs) in Severe SARS-CoV-2 Lung Disease.
International journal of molecular sciences, , Aug-17, Volume: 22, Issue:16, 2021

Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm.
Biomaterials, , Volume: 267, 2021

JAGN1 is required for fungal killing in neutrophil extracellular traps: Implications for severe congenital neutropenia.
Journal of leukocyte biology, , Volume: 104, Issue:6, 2018

Lysine 53 Acetylation of Cytochrome
Cells, , 04-03, Volume: 10, Issue:4, 2021

Interactions between inflammatory activation and endothelial dysfunction selectively modulate valve disease progression in patients with bicuspid aortic valve.
Heart (British Cardiac Society), , Volume: 100, Issue:10, 2014

Association between myeloperoxidase and the risks of ischemic stroke, heart failure, and atrial fibrillation: A Mendelian randomization study.
Nutrition, metabolism, and cardiovascular diseases : NMCD, , Volume: 33, Issue:1, 2023

Increase in the number of new cases of ANCA-associated vasculitis in the COVID-19 vaccine era.
Clinical immunology (Orlando, Fla.), , Volume: 252, 2023

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Paper-based colorimetric detection of COVID-19 using aptasenor based on biomimetic peroxidase like activity of ChF/ZnO/CNT nano-hybrid.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, , Nov-15, Volume: 301, 2023

Quantifying Myeloperoxidase-DNA and Neutrophil Elastase-DNA Complexes from Neutrophil Extracellular Traps by Using a Modified Sandwich ELISA.
Journal of visualized experiments : JoVE, , 05-12, Issue:195, 2023

Anti-glomerular Basement Membrane Disease Concomitant with MPO-ANCA Positivity Concurrent with High Serum Levels of Interleukin-26 Following Coronavirus Disease 2019 Vaccination.
Internal medicine (Tokyo, Japan), , Apr-01, Volume: 62, Issue:7, 2023

Myeloperoxidase-derived hypochlorous acid targets human airway epithelial plasmalogens liberating protein modifying electrophilic 2-chlorofatty aldehydes.
Redox biology, , Volume: 59, 2023

Correlations of Myeloperoxidase (MPO), Adenosine deaminase (ADA), C-C motif chemokine 22 (CCL22), Tumour necrosis factor alpha (TNFα) and Interleukin-6 (IL-6) mRNA expression in the nasopharyngeal specimens with the diagnosis and severity of SARS-CoV-2 in
Emerging microbes & infections, , Volume: 12, Issue:1, 2023

Development of ANCA-associated vasculitis followed by SARS-CoV-2 vaccination in a patient with HLA-DRB1*09:01 allele.
Modern rheumatology case reports, , 06-19, Volume: 7, Issue:2, 2023

Neutrophils drive pulmonary vascular leakage in MHV-1 infection of susceptible A/J mice.
Frontiers in immunology, , Volume: 13, 2022

Ultrasensitive aptamer-functionalized Cu-MOF fluorescent nanozyme as an optical biosensor for detection of C-reactive protein.
Analytical biochemistry, , 12-01, Volume: 658, 2022

Metabolic reprograming shapes neutrophil functions in severe COVID-19.
European journal of immunology, , Volume: 52, Issue:3, 2022

Complement Activation
Frontiers in immunology, , Volume: 13, 2022

Can the Prognosis of COVID-19 Disease Be Determined by Fecal Markers and Cytokines?
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, , Volume: 42, Issue:10, 2022

Myeloperoxidase-mediated solution demonstrates rapid virucidal properties against the delta variant of SARS-CoV-2.
The Journal of hospital infection, , Volume: 123, 2022

Antineutrophil Cytoplasmic Antibody-associated Vasculitis after COVID-19 Vaccination with Pfizer-BioNTech.
Internal medicine (Tokyo, Japan), , Volume: 61, Issue:19, 2022

Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19.
EBioMedicine, , Volume: 83, 2022

Investigation of the effects of three different generations of fluoroquinolone derivatives on antioxidant and immunotoxic enzyme levels in different rat tissues.
Drug and chemical toxicology, , Volume: 45, Issue:6, 2022

Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia.
Frontiers in immunology, , Volume: 13, 2022

MPO-ANCA-positive Microscopic Polyangiitis Following COVID-19 Infection.
Internal medicine (Tokyo, Japan), , Feb-15, Volume: 61, Issue:4, 2022

Neutrophil Extracellular Traps in Fatal COVID-19-Associated Lung Injury.
Disease markers, , Volume: 2021, 2021

A Multiple-Hit Hypothesis Involving Reactive Oxygen Species and Myeloperoxidase Explains Clinical Deterioration and Fatality in COVID-19.
International journal of biological sciences, , Volume: 17, Issue:1, 2021

Pediatric P-ANCA vasculitis following COVID-19.
Pediatric pulmonology, , Volume: 56, Issue:10, 2021

Neutrophil Extracellular Traps (NETs) in Severe SARS-CoV-2 Lung Disease.
International journal of molecular sciences, , Aug-17, Volume: 22, Issue:16, 2021

Development and application of a SARS-CoV-2 colorimetric biosensor based on the peroxidase-mimic activity of γ-Fe
Mikrochimica acta, , Sep-09, Volume: 188, Issue:10, 2021

Enhanced Expression of Autoantigens During SARS-CoV-2 Viral Infection.
Frontiers in immunology, , Volume: 12, 2021

Myeloperoxidase anti-neutrophil cytoplasmic antibody positive optic perineuritis after mRNA coronavirus disease-19 vaccine.
QJM : monthly journal of the Association of Physicians, , 12-20, Volume: 114, Issue:10, 2021

Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm.
Biomaterials, , Volume: 267, 2021

Elevated Levels of Neutrophil Activated Proteins, Alpha-Defensins (DEFA1), Calprotectin (S100A8/A9) and Myeloperoxidase (MPO) Are Associated With Disease Severity in COVID-19 Patients.
Frontiers in cellular and infection microbiology, , Volume: 11, 2021

Russelioside B; A pregnane glycoside for treatment of gastric ulcer via modulation of heat shock protein-70 and vascular endothelial growth factor.
Steroids, , Volume: 165, 2021

Blood myeloperoxidase-DNA, a biomarker of early response to SARS-CoV-2 infection?
Allergy, , Volume: 76, Issue:3, 2021

Melatonin interferes with COVID-19 at several distinct ROS-related steps.
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[no title available]
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The nitroderivative of aspirin, NCX 4016, reduces infarct size caused by myocardial ischemia-reperfusion in the anesthetized rat.
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Magnolol reduces myocardial ischemia/reperfusion injury via neutrophil inhibition in rats.
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[A case of idiopathic pulmonary arteritis with positive anti-myeloperoxidase antibodies].
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Correlation of antineutrophil cytoplasmic antibodies with the extrarenal histopathology of Wegener's (pathergic) granulomatosis and related forms of vasculitis.
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Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats.
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Temporomandibular joint arthritis as an initial presentation of acute myeloid leukemia with myelodysplasia-related changes: a report of an unusual case.
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Treatment with Selemax®, a selenium-enriched yeast, ameliorates experimental arthritis in rats and mice.
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Expression of Fas ligand improves the effect of IL-4 in collagen-induced arthritis.
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The type II decoy receptor of IL-1 inhibits murine collagen-induced arthritis.
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Advanced healthcare materials, , Volume: 11, Issue:1, 2022

Iron Phosphate Nanozyme-Hydrogel with Multienzyme-like Activity for Efficient Bacterial Sterilization.
ACS applied materials & interfaces, , Apr-27, Volume: 14, Issue:16, 2022

An intrinsically thermogenic nanozyme for synergistic antibacterial therapy.
Biomaterials science, , Dec-07, Volume: 9, Issue:24, 2021

COVID-19 associated Kikuchi-Fujimoto disease.
British journal of haematology, , Volume: 192, Issue:5, 2021

Diagnosis of bacterial urinary tract infection: Utility of urine myeloperoxidase concentration to predict urine culture results in dogs.
PloS one, , Volume: 15, Issue:5, 2020

Neutrophil Elastase Activity as a Surrogate Marker for Neutrophil Extracellular Trap Formation following Hematopoietic Stem Cell Transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, , Volume: 25, Issue:12, 2019

Associations of periparturient plasma biochemical parameters, endometrial leukocyte esterase and myeloperoxidase, and bacterial detection with clinical and subclinical endometritis in postpartum dairy cows.
The Journal of veterinary medical science, , Feb-20, Volume: 80, Issue:2, 2018

A H
Nanoscale, , Sep-27, Volume: 10, Issue:37, 2018

Unraveling the Enzymatic Activity of Oxygenated Carbon Nanotubes and Their Application in the Treatment of Bacterial Infections.
Nano letters, , 06-13, Volume: 18, Issue:6, 2018

Methods for In Vivo/Ex Vivo Analysis of Antimicrobial Peptides in Bacterial Keratitis: siRNA Knockdown, Colony Counts, Myeloperoxidase, Immunostaining, and RT-PCR Assays.
Methods in molecular biology (Clifton, N.J.), , Volume: 1548, 2017

Serum levels of the soluble haemoglobin scavenger receptor CD163 in MPO-ANCA-associated renal vasculitis.
Scandinavian journal of rheumatology, , Volume: 45, Issue:5, 2016

Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology.
PloS one, , Volume: 11, Issue:1, 2016

Laccase-assisted formation of bioactive chitosan/gelatin hydrogel stabilized with plant polyphenols.
Carbohydrate polymers, , Feb-15, Volume: 92, Issue:2, 2013

Equine myeloperoxidase: a novel biomarker in synovial fluid for the diagnosis of infection.
Equine veterinary journal, , Volume: 45, Issue:3, 2013

Serum procalcitonin levels in patients with myeloperoxidase-antineutrophil cytoplasmic antibodies-associated glomerulonephritis.
The American journal of the medical sciences, , Volume: 343, Issue:2, 2012

Liver injury and abscess formation in secondary murine peritonitis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 60, Issue:4, 2011

Serum ratio of soluble triggering receptor expressed on myeloid cells-1 to creatinine is a useful marker of infectious complications in myeloperoxidase-antineutrophil cytoplasmic antibody-associated renal vasculitis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 26, Issue:3, 2011

Clinical and immunological features of drug-induced and infection-induced proteinase 3-antineutrophil cytoplasmic antibodies and myeloperoxidase-antineutrophil cytoplasmic antibodies and vasculitis.
Current opinion in rheumatology, , Volume: 22, Issue:1, 2010

Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injury.
Surgery, , Volume: 148, Issue:3, 2010

Association between the neutrophil myeloperoxidase index and subsets of bacterial infections.
International journal of laboratory hematology, , Volume: 32, Issue:6 Pt 2, 2010

Utility of reflexive semen cultures for detecting bacterial infections in patients with infertility and leukocytospermia.
Fertility and sterility, , Volume: 91, Issue:4 Suppl, 2009

Biology of the eosinophil.
Advances in immunology, , Volume: 101, 2009

[Immunotropic effects of probiotic complex bactistatin used simultaneously with antibiotics].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], , Volume: 53, Issue:1-2, 2008

Use of pharmacodynamic endpoints for the evaluation of levofloxacin for the treatment of acute maxillary sinusitis.
Diagnostic microbiology and infectious disease, , Volume: 61, Issue:1, 2008

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.
Antioxidants & redox signaling, , Volume: 10, Issue:2, 2008

Immunobiological changes of in vivo glucocorticoid depleted male Swiss albino rats.
Immunobiology, , Volume: 212, Issue:1, 2007

Study of the efficacy of Coated VICRYL Plus Antibacterial suture (coated Polyglactin 910 suture with Triclosan) in two animal models of general surgery.
The Journal of infection, , Volume: 54, Issue:1, 2007

Intraabdominal bacterial infections significantly alter regeneration and function of the liver in a rat model of major hepatectomy.
Langenbeck's archives of surgery, , Volume: 392, Issue:3, 2007

Mean peroxidase index as a potential marker for neonatal infection.
The Pediatric infectious disease journal, , Volume: 25, Issue:12, 2006

Organ specific apoptosis following polymicrobial intraperitoneal infection.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 55, Issue:4, 2006

[Production of active oxygen by neutrophils in patients with cancer of the esophagus and stomach before and after surgical interventions].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], , Volume: 50, Issue:4, 2005

Leukotriene B4 receptor (BLT-1) modulates neutrophil influx into the peritoneum but not the lung and liver during surgically induced bacterial peritonitis in mice.
Clinical and diagnostic laboratory immunology, , Volume: 11, Issue:5, 2004

Reevaluating gel-forming mucins' roles in cystic fibrosis lung disease.
Free radical biology & medicine, , Nov-15, Volume: 37, Issue:10, 2004

Genetic background determines susceptibility during murine septic peritonitis.
The Journal of surgical research, , Volume: 102, Issue:1, 2002

Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine, , Volume: 163, Issue:2, 2001

Endothelial E- and P-selectin expression in iNOS- deficient mice exposed to polymicrobial sepsis.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 280, Issue:2, 2001

Soluble adhesion molecules, cytokines and cellular markers in serum in patients with acute infections.
Scandinavian journal of infectious diseases, , Volume: 33, Issue:4, 2001

Bronchial inflammation: its relationship to colonizing microbial load and alpha(1)-antitrypsin deficiency.
Chest, , Volume: 117, Issue:5 Suppl 1, 2000

Immunopathology of a two-hit murine model of acid aspiration lung injury.
American journal of physiology. Lung cellular and molecular physiology, , Volume: 278, Issue:3, 2000

Differential host susceptibility to pulmonary infections with bacteria and fungi in mice deficient in myeloperoxidase.
The Journal of infectious diseases, , Volume: 182, Issue:4, 2000

Therapeutic efficacy of continuous arterial infusion of an antibiotic and a protease inhibitor via the superior mesenteric artery for acute pancreatitis in an animal model.
Pancreas, , Volume: 21, Issue:3, 2000

Evidence for excessive bronchial inflammation during an acute exacerbation of chronic obstructive pulmonary disease in patients with alpha(1)-antitrypsin deficiency (PiZ).
American journal of respiratory and critical care medicine, , Volume: 160, Issue:6, 1999

Temporal sequence of pulmonary and systemic inflammatory responses to graded polymicrobial peritonitis in mice.
Infection and immunity, , Volume: 67, Issue:11, 1999

Proteinase 3 mRNA expression is induced in monocytes but not in neutrophils of patients with cystic fibrosis.
FEBS letters, , Sep-03, Volume: 457, Issue:3, 1999

The effects of two antiinflammatory pretreatments on bacterial-induced lung injury.
Anesthesiology, , Volume: 90, Issue:6, 1999

CNI-1493 attenuates hemodynamic and pro-inflammatory responses to LPS.
Shock (Augusta, Ga.), , Volume: 10, Issue:5, 1998

Myeloperoxidase in urine: a new marker for distinction between rejection and urinary tract infection after renal transplantation.
Transplantation proceedings, , Volume: 29, Issue:7, 1997

Role of oxidants in microbial pathophysiology.
Clinical microbiology reviews, , Volume: 10, Issue:1, 1997

Differential excretion of leucocyte granule components in inflammatory bowel disease: implications for pathogenesis.
Clinical science (London, England : 1979), , Volume: 92, Issue:3, 1997

Incrimination of anaerobic bacteria in the induction of experimental colitis.
The American journal of physiology, , Volume: 272, Issue:1 Pt 1, 1997

Disorders of neutrophil function.
Blood reviews, , Volume: 9, Issue:3, 1995

The differential release of eosinophil granule proteins. Studies on patients with acute bacterial and viral infections.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 25, Issue:8, 1995

Serum levels of granulocyte-colony stimulating factor (G-CSF) in bacterial and viral infections, and in atypical pneumonia.
British journal of haematology, , Volume: 88, Issue:2, 1994

[Prognostic value of the leukogram and the myeloperoxidase activity of neutrophilic granulocytes in infectious complications in children with severe burns].
Klinicheskaia khirurgiia, , Issue:3, 1992

Impaired neutrophil bactericidal activity correlates with the infection occurring after surgery for esophageal cancer.
Journal of surgical oncology, , Volume: 51, Issue:3, 1992

Fast double antibody radioimmunoassay of human granulocyte myeloperoxidase and its application to plasma.
Journal of immunological methods, , Mar-21, Volume: 137, Issue:2, 1991

Detection of anti-myeloperoxidase and anti-elastase antibodies in vasculitides and infections.
Clinical and experimental immunology, , Volume: 84, Issue:2, 1991

Role of neutrophils in the intestinal alterations associated with thermal injury.
Burns : journal of the International Society for Burn Injuries, , Volume: 16, Issue:5, 1990

Studies on phagocytosis in patients with acute bacterial infections.
The Journal of clinical investigation, , Volume: 83, Issue:1, 1989

[Insufficiency of intra-abdominal immunity to infection in purulent peritonitis--sequela of disordered foreign body opsonization].
Klinische Wochenschrift, , Mar-15, Volume: 67, Issue:6, 1989

[Myeloperoxidase deficiency of the peripheral blood neutrophils and the incidence of infectious complications in patients with acute myeloblastic leukemia].
Vrachebnoe delo, , Issue:3, 1989

Granulocyte chemiluminescence in patients with postoperative infections.
Archives of surgery (Chicago, Ill. : 1960), , Volume: 123, Issue:1, 1988

[Myeloperoxidase activity of neutrophils and the frequency of emergence of infectious complications in myeloproliferative disorders].
Arkhiv patologii, , Volume: 50, Issue:1, 1988

Acquired myeloperoxidase deficiency of neutrophils in a patient with aplastic anemia (idiopathic marrow aplasia).
Acta haematologica, , Volume: 80, Issue:2, 1988

Chemiluminescence response of polymorphonuclear leucocytes to serum-opsonized zymosan--a predictive parameter for infections and prognosis in multiple myeloma patients.
Clinical and laboratory haematology, , Volume: 10, Issue:4, 1988

[Clinical significance of the bactericidal systems in endogenous infections].
Klinicheskaia meditsina, , Volume: 64, Issue:4, 1986

NBT dye reduction test & myeloperoxidase activity of neutrophils in pregnant & non-pregnant women.
The Indian journal of medical research, , Volume: 81, 1985

Automated cytochemical differential leucocyte count in patients hospitalized with acute bacterial infections.
Scandinavian journal of infectious diseases, , Volume: 17, Issue:2, 1985

Myelolactoferrin index (MLF) and myelopoiesis during bacterial infections and malignant diseases.
Haematology and blood transfusion, , Volume: 29, 1985

Neutrophil myeloperoxidase concentration: changes with development and during bacterial infection.
Pediatric research, , Volume: 19, Issue:12, 1985

Serum-levels of lactoferrin, lysozyme and myeloperoxidase in normal, infection-prone and leukemic children.
Clinica chimica acta; international journal of clinical chemistry, , Jan-31, Volume: 136, Issue:2-3, 1984

Defective bactericidal activity and absence of specific granules in neutrophils from a patient with recurrent bacterial infections.
Journal of clinical immunology, , Volume: 4, Issue:1, 1984

[Myeloperoxidase deficiency in polymorphonuclear cells of children with recurrent infections].
Boletin medico del Hospital Infantil de Mexico, , Volume: 41, Issue:11, 1984

Myeloperoxidase-deficient polymorphonuclear leucocytes (III): Relation to incidence of infection in acute myeloid leukaemia.
Scandinavian journal of haematology, , Volume: 33, Issue:1, 1984

Effect of two antibiotics on human granulocyte activities.
The Journal of antimicrobial chemotherapy, , Volume: 11, Issue:6, 1983

Association of neutrophil chemiluminescence with microbicidal activity.
Clinical immunology and immunopathology, , Volume: 22, Issue:2, 1982

Susceptibility of Legionella pneumophila to oxygen-dependent microbicidal systems.
Journal of immunology (Baltimore, Md. : 1950), , Volume: 129, Issue:5, 1982

[Role of neutrophilic leukocytes in the immune response to infection].
Revista clinica espanola, , Dec-31, Volume: 167, Issue:6, 1982

[Iron and infection].
Padiatrie und Grenzgebiete, , Volume: 20, Issue:1-2, 1981

[Lysosomal-cation test and the prospects of its use in pathomorphological and laboratory diagnostic practice].
Arkhiv patologii, , Volume: 41, Issue:5, 1979

Bactericidal activity of human neutrophil granulocytes. Studies in clinical disorders with the in vitro bactericidal test.
Acta pathologica et microbiologica Scandinavica. Supplement, , Issue:266, 1978

Neutrophil and eosinophil granulocytes in bacterial infection: sequential studies of cellular and serum levels of granule proteins.
British journal of haematology, , Volume: 38, Issue:4, 1978

Oxygen-dependent microbial killing by phagocytes (second of two parts).
The New England journal of medicine, , Mar-30, Volume: 298, Issue:13, 1978

Neutrophilic granulocytes in acute bacterial infection. Sequential studies on lysozyme, myeloperoxidase and lactoferrin.
Clinical and experimental immunology, , Volume: 26, Issue:3, 1976

Iron and immunocompetence.
Nutrition reviews, , Volume: 34, Issue:5, 1976

Particle-induced myeloperoxidase release in serially diluted whole blood quantifies the number and the phagocytic activity of blood neutrophils and opsonization capacity of plasma.
Luminescence : the journal of biological and chemical luminescence, , Volume: 21, Issue:3

[Study of the functional capacity of the neutrophil granulocyte by means of the NBT reduction test].
Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna, , Volume: 30, Issue:3

Lipoprotein-associated phospholipase A2, myeloperoxidase and vascular endothelial growth factor - predictors of high vascular risk in respiratory bacterial infections.
Journal of medicine and life, , Volume: 9, Issue:4

Diagnosis of bacterial urinary tract infection: Utility of urine myeloperoxidase concentration to predict urine culture results in dogs.
PloS one, , Volume: 15, Issue:5, 2020

False 'hematuria' due to bacteriuria.
Archives of pathology & laboratory medicine, , Volume: 119, Issue:8, 1995

A study for the improvement of the cytological urine examination performances in upper tract infection diagnosis.
Roumanian archives of microbiology and immunology, , Volume: 62, Issue:3-4

Evaluation of a 4-protein serum biomarker panel-biglycan, annexin-A6, myeloperoxidase, and protein S100-A9 (B-AMP)-for the detection of esophageal adenocarcinoma.
Cancer, , Dec-15, Volume: 120, Issue:24, 2014

Long-term results of ablation with antireflux surgery for Barrett's esophagus: a clinical and molecular biologic study.
Surgical endoscopy, , Volume: 26, Issue:7, 2012

Effect of inflammation on cyclooxygenase (COX)-2 expression in benign and malignant oesophageal cells.
Carcinogenesis, , Volume: 26, Issue:9, 2005

Simultaneous progression of oxidative stress and angiogenesis in malignant transformation of Barrett esophagus.
The Journal of thoracic and cardiovascular surgery, , Volume: 126, Issue:6, 2003

Oxidative stress has a role in malignant transformation in Barrett's oesophagus.
International journal of cancer, , Dec-20, Volume: 102, Issue:6, 2002

Mucosal reactive oxygen species production in oesophagitis and Barrett's oesophagus.
Gut, , Volume: 37, Issue:2, 1995

[Case of microscopic polyangiitis accompanied by central nervous system symptoms and brain vasculitis observed histopathologically].
Nihon Jinzo Gakkai shi, , Volume: 53, Issue:4, 2011

IL-8 Triggers Neutrophil Extracellular Trap Formation Through an Nicotinamide Adenine Dinucleotide Phosphate Oxidase- and Mitogen-Activated Protein Kinase Pathway-Dependent Mechanism in Uveitis.
Investigative ophthalmology & visual science, , 10-03, Volume: 64, Issue:13, 2023

Oxidases and oxygenases in regulation of neutrophil redox pathways in Behçet's disease patients.
Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:1, 2012

Lack of association of the -463 G/A myeloperoxidase promoter polymorphism with Behcet's disease in Italian patients.
Rheumatology (Oxford, England), , Volume: 46, Issue:10, 2007

Increased advanced oxidation protein products in Behçet's disease: a new activity marker?
The British journal of dermatology, , Volume: 151, Issue:1, 2004

Enhancement of endothelial cell E-selectin expression by sera from patients with active Behçet's disease: moderate correlation with anti-endothelial cell antibodies and serum myeloperoxidase levels.
Clinical immunology (Orlando, Fla.), , Volume: 91, Issue:3, 1999

Oxidative stress and antioxidant defenses in plasma of patients with Behçet's disease.
The Tohoku journal of experimental medicine, , Volume: 176, Issue:4, 1995

Types of ocular attacks and lysosomal enzymes in Behçet's disease.
Japanese journal of ophthalmology, , Volume: 28, Issue:1, 1984

[Types of ocular attacks and lysosomal enzymes in Behçet's disease (author's transl)].
Nippon Ganka Gakkai zasshi, , Sep-10, Volume: 85, Issue:9, 1981

[Lysosomal enzymes of leucocytes in Behçet's disease (author's transl)].
Nippon Ganka Gakkai zasshi, , Sep-10, Volume: 84, Issue:9, 1980

Polymorphonuclear leukocyte myeloperoxidase levels in patients with Behçet's disease.
Clinical and experimental rheumatology, , Volume: 18, Issue:4

THREE UNEXPECTED PRODUCTS OF PEROXIDASE REACTION; BRAIN SITE OF LESION, BERIBERI POISON AND NEW DISEASE.
The Tohoku journal of experimental medicine, , Jul-25, Volume: 83, 1964

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma.
International journal of molecular sciences, , Jan-28, Volume: 21, Issue:3, 2020

Nonleukemic granulocytic sarcoma in the bile duct: a case report.
Journal of Korean medical science, , Volume: 21, Issue:4, 2006

Protective Effects of Curcumin on Intestinal Damage in Cholestatic Rats.
Journal of investigative surgery : the official journal of the Academy of Surgical Research, , Volume: 29, Issue:3, 2016

Ethyl pyruvate prevents intestinal inflammatory response and oxidative stress in a rat model of extrahepatic cholestasis.
The Journal of surgical research, , May-15, Volume: 160, Issue:2, 2010

The NF-kappaB inhibitors attenuate hepatic injury in bile duct ligated rats.
Pediatric surgery international, , Volume: 22, Issue:8, 2006

Allopurinol and glutamine attenuate bacterial translocation in chronic portal hypertensive and common bile duct ligated growing rats.
Gut, , Volume: 39, Issue:1, 1996

[Evaluation of antimicrobial system of polymorphonuclear leukocytes and opsonic activity in patients with congenital biliary atresia].
Nihon Geka Gakkai zasshi, , Volume: 94, Issue:2, 1993

Impaired polymorphonuclear leukocyte function in biliary atresia: role of bilirubin and bile acids.
Journal of pediatric surgery, , Volume: 22, Issue:10, 1987

Evaluation of prognostic significance of granulocyte-related factors in cancer patients undergoing personalized peptide vaccination.
Human vaccines & immunotherapeutics, , Volume: 11, Issue:12, 2015

Chemoprevention of biliary carcinogenesis in syrian hamsters by the novel carboxamide derivative IS-741 after initiation with N-nitrosobis(2-oxopropyl)amine (BOP).
Carcinogenesis, , Volume: 21, Issue:8, 2000

Assessment of a multi-assay biological diagnostic test for mood disorders in a Japanese population.
Neuroscience letters, , Jan-26, Volume: 612, 2016

Oxidative markers of Myeloperoxidase and Catalase and their diagnostic performance in bipolar disorder.
Journal of affective disorders, , Aug-01, Volume: 181, 2015

A prospective study of myeloperoxidase levels in water immersion.
Placenta, , 06-01, Volume: 123, 2022

Myeloperoxidase as cardiovascular risk marker in pre-pubertal preterm children?
Nutrition, metabolism, and cardiovascular diseases : NMCD, , Volume: 29, Issue:12, 2019

Oxidative stress during early pregnancy and birth outcomes.
Public health nutrition, , Volume: 19, Issue:17, 2016

Concentrations of neutrophil-derived proteins in meconium and their correlations.
Biomarkers in medicine, , Volume: 10, Issue:8, 2016

Depression in pregnancy is associated with decreased glutathione peroxidase activity in fetal cord blood.
Journal of psychiatric research, , Volume: 79, 2016

Elevated blood levels of inflammation-related proteins are associated with an attention problem at age 24 mo in extremely preterm infants.
Pediatric research, , Volume: 75, Issue:6, 2014

Evaluation of the relationship between adenosine deaminase, myeloperoxidase, cholinesterase, preeclampsia severity, and neonatal outcomes.
Clinical and experimental hypertension (New York, N.Y. : 1993), , Volume: 34, Issue:7, 2012

Closure of patent ductus arteriosus decreases pulmonary myeloperoxidase in premature infants with respiratory distress syndrome.
Biology of the neonate, , Volume: 67, Issue:3, 1995

Montelukast reduces ischaemia/reperfusion-induced bladder dysfunction and oxidant damage in the rat.
The Journal of pharmacy and pharmacology, , Volume: 59, Issue:6, 2007

Effect of the phytotherapeutic agent eviprostat on the bladder in a rat model of bladder overdistension/emptying.
Neurourology and urodynamics, , Volume: 32, Issue:7, 2013

Complex relationships between occupation, environment, DNA adducts, genetic polymorphisms and bladder cancer in a case-control study using a structural equation modeling.
PloS one, , Volume: 9, Issue:4, 2014

Arsenic methylation capability, myeloperoxidase and sulfotransferase genetic polymorphisms, and the stage and grade of urothelial carcinoma.
Urologia internationalis, , Volume: 82, Issue:2, 2009

[Case 8. Perspectives in 2007 for bladder pathology. Prostatic adenocarcinoma invading the bladder].
Annales de pathologie, , Volume: 28, Issue:4, 2008

Using hierarchical modeling in genetic association studies with multiple markers: application to a case-control study of bladder cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , Volume: 13, Issue:6, 2004

Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk.
Carcinogenesis, , Volume: 25, Issue:6, 2004

Extramedullary myeloid cell tumor of the urinary bladder in a patient with myelodysplastic syndrome.
Pathology, research and practice, , Volume: 195, Issue:10, 1999

Granulocyte-colony stimulating factor, granulocyte-macrophage colony stimulating factor and interleukin 4 induce differentiation in the U-937 human monocytic leukemia cell line.
Leukemia & lymphoma, , Volume: 22, Issue:1-2, 1996

Myeloperoxidase activity and whole blood chemiluminescence in bladder cancer--influence of smoking.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, , Volume: 46, Issue:6, 1994

Towards an understanding of the mode of action of Bacillus Calmette-Guérin-therapy in bladder cancer treatment, especially with regard to the role of fibronectin.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, , Volume: 30, Issue:9, 1992

A case of renal granulomatosis with polyangiitis following intravesical bacillus Calmette-Guérin therapy.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, , Volume: 29, Issue:1

Comprehensive analysis of a myeloperoxidase-negative acute promyelocytic leukemia.
Blood, , 01-05, Volume: 129, Issue:1, 2017

Expression of myeloperoxidase and gene mutations in AML patients with normal karyotype: double CEBPA mutations are associated with high percentage of MPO positivity in leukemic blasts.
International journal of hematology, , Volume: 94, Issue:1, 2011

Process to evaluate hematological parameters that reflex to manual differential cell counts in a pediatric institution.
Clinical laboratory, , Volume: 56, Issue:1-2, 2010

Acute myeloid leukemia associated with t(10;17)(p13-15;q12-21) and phagocytic activity by leukemic blasts: a clinical study and review of the literature.
Cancer genetics and cytogenetics, , Oct-01, Volume: 202, Issue:1, 2010

An updated approach to the diagnosis of myeloid leukemia cutis.
American journal of clinical pathology, , Volume: 132, Issue:1, 2009

The percentage of myeloperoxidase-positive blast cells is a strong independent prognostic factor in acute myeloid leukemia, even in the patients with normal karyotype.
Leukemia, , Volume: 17, Issue:8, 2003

Expression of NK-associated antigens in extramedullary lymph nodal blast crisis of chronic myeloid leukemia on fine-needle cytology.
Diagnostic cytopathology, , Volume: 27, Issue:3, 2002

Acute myeloid leukemia with hypergranular cytoplasm: a differential diagnosis of acute promyelocytic leukemia.
Leukemia research, , Volume: 24, Issue:11, 2000

Blast crisis of chronic myelogenous leukemia exhibiting immunophenotypic features of a myeloid/natural killer cell precursor.
International journal of hematology, , Volume: 69, Issue:2, 1999

Myeloperoxidase mRNA analysis in acute lymphoblastic leukemia.
Diagnostic molecular pathology : the American journal of surgical pathology, part B, , Volume: 6, Issue:3, 1997

The value of the ultrastructural pattern of myeloperoxidase and platelet peroxidase in identification of two blastic cell types during transformation of a chronic myeloproliferative disorder.
Haematologia, , Volume: 27, Issue:3, 1996

Myeloperoxidase mRNA analysis in acute lymphoblastic leukemia.
Diagnostic molecular pathology : the American journal of surgical pathology, part B, , Volume: 5, Issue:4, 1996

Immunophenotype and ultrastructural studies in blast crisis of chronic myeloid leukemia.
Leukemia & lymphoma, , Volume: 19, Issue:3-4, 1995

Monoclonal antibody anti-MPO is useful in recognizing minimally differentiated acute myeloid leukaemia.
Leukemia & lymphoma, , Volume: 12, Issue:3-4, 1994

Use of polyclonal anti-myeloperoxidase antibody in myeloid lineage determination.
The Indian journal of medical research, , Volume: 100, 1994

Establishment of a new cell line with the characteristics of a multipotential progenitor from a patient with chronic myelogenous leukemia in early erythroblastic crisis.
Leukemia, , Volume: 8, Issue:1, 1994

Detection of leukemic blasts in peripheral blood specimens by reverse transcriptase polymerase chain reaction assay for myeloperoxidase mRNA.
Diagnostic molecular pathology : the American journal of surgical pathology, part B, , Volume: 2, Issue:4, 1993

Ultrastructural and ultracytochemical differences between megakaryoblastic leukemia in children and adults. Analysis of 49 patients.
Cancer, , Jul-15, Volume: 70, Issue:2, 1992

Differentiation induction of blast cells in two cases of childhood acute megakaryoblastic leukemia in vitro by interleukin-3 and interleukin-6: an ultrastructural cytochemical study.
Journal of cellular physiology, , Volume: 148, Issue:3, 1991

Expression of the myeloperoxidase gene in acute and chronic myeloid leukemias: relationship to the expression of cell cycle-related genes.
Leukemia, , Volume: 3, Issue:6, 1989

Clinical significance of low levels of myeloperoxidase positivity in childhood acute nonlymphoblastic leukemia.
Blood, , Volume: 70, Issue:1, 1987

Bilineage T-lymphoblastic/myeloid extramedullary blast crisis in chronic myelogenous leukemia.
Indian journal of pathology & microbiology, , Volume: 59, Issue:1

Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum.
Behavioural brain research, , 03-15, Volume: 340, 2018

Low-Level Blast Exposure Increases Transient Receptor Potential Vanilloid 1 (TRPV1) Expression in the Rat Cornea.
Current eye research, , Volume: 41, Issue:10, 2016

Regional traumatic limb hypothermia attenuates distant hepatic and renal injury following blast limb trauma in rats.
The journal of trauma and acute care surgery, , Volume: 77, Issue:3, 2014

Transient regional hypothermia applied to a traumatic limb attenuates distant lung injury following blast limb trauma.
Critical care medicine, , Volume: 42, Issue:1, 2014

Contribution of systemic factors in the pathophysiology of repeated blast-induced neurotrauma.
Neuroscience letters, , Feb-28, Volume: 539, 2013

Lung injury following lower extremity blast trauma in rats.
The journal of trauma and acute care surgery, , Volume: 73, Issue:6, 2012

Inflammatory leukocytes and iron turnover in experimental hemorrhagic lung trauma.
Experimental and molecular pathology, , Volume: 80, Issue:1, 2006

Lung injury and recovery after exposure to blast overpressure.
The Journal of trauma, , Volume: 61, Issue:4, 2006

Leukotrienes in the pathogenesis of pulmonary blast injury.
The Journal of trauma, , Volume: 40, Issue:3 Suppl, 1996

Adjunctive treatment of murine neuroblastoma with 6-hydroxydopamine and Tempol.
Cancer research, , May-15, Volume: 56, Issue:10, 1996

MPO-ANCA Vasculitis Pachymeningitis with Bilateral Vision Loss.
Minnesota medicine, , Volume: 98, Issue:8, 2015

Relationship between the development of blindness in Churg-Strauss syndrome and anti-myeloperoxidase antibodies.
British journal of rheumatology, , Volume: 36, Issue:2, 1997

Histopathological and immunohistochemical evaluation of nitrogen mustard-induced cutaneous effects in SKH-1 hairless and C57BL/6 mice.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, , Volume: 66, Issue:2-3, 2014

Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries.
Toxicology, , Jun-05, Volume: 320, 2014

Proteomic kinetic analysis of blister fluid and serum in a patient with drug-induced toxic epidermal necrolysis. A comparison with skin immunohistochemistry.
Current drug safety, , Nov-01, Volume: 7, Issue:5, 2012

2-Chloroethyl ethyl sulfide causes microvesication and inflammation-related histopathological changes in male hairless mouse skin.
Toxicology, , Apr-11, Volume: 282, Issue:3, 2011

Functionally active macrophage-derived myeloperoxidase in the skin of drug-induced toxic epidermal necrolysis.
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The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo.
Cell, , Sep-01, Volume: 102, Issue:5, 2000

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[no title available]
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[no title available]
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Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.
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Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice.
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Effects of aging on complement activation and neutrophil infiltration after intracerebral hemorrhage.
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Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents.
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Intracerebral hemorrhage-induced brain injury is aggravated in senescence-accelerated prone mice.
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Neuroprotection following fluid percussion brain trauma: a pilot study using quercetin.
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Enhanced oxidative stress in iNOS-deficient mice after traumatic brain injury: support for a neuroprotective role of iNOS.
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Characterization of a rat model to study acute neuroinflammation on histopathological, biochemical and functional outcomes.
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Administration of either anti-intercellular adhesion molecule-1 or a nonspecific control antibody improves recovery after traumatic brain injury in the rat.
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Systemic LPS injection leads to granulocyte influx into normal and injured brain: effects of ICAM-1 deficiency.
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Importance of posttraumatic hypothermia and hyperthermia on the inflammatory response after fluid percussion brain injury: biochemical and immunocytochemical studies.
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Local neutrophil influx following lateral fluid-percussion brain injury in rats is associated with accumulation of complement activation fragments of the third component (C3) of the complement system.
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A therapeutic cancer vaccine against GL261 murine glioma.
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37-year-old woman with multiple intracranial masses.
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Aptamer-Functionalized Ce
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Biodegradable and Peroxidase-Mimetic Boron Oxynitride Nanozyme for Breast Cancer Therapy.
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Cardiac monitoring in HER2-positive patients on trastuzumab treatment: A review and implications for clinical practice.
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Changes in Cardiovascular Biomarkers With Breast Cancer Therapy and Associations With Cardiac Dysfunction.
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High peroxidasin-like expression is a potential and independent prognostic biomarker in breast cancer.
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[no title available]
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Cardiac biomarkers, cardiotoxicity, and active collaboration: is this the final frontier or the wave we should catch?
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Highly efficient colorimetric detection of target cancer cells utilizing superior catalytic activity of graphene oxide-magnetic-platinum nanohybrids.
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Immunohistochemistry on frozen section of sentinel lymph nodes in breast cancer with improved morphology and blocking of endogenous peroxidase.
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Granulocytic sarcoma of breast: an aleukemic presentation.
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Polymorphisms in genes related to oxidative stress (CAT, MnSOD, MPO, and eNOS) and acute toxicities from radiation therapy following lumpectomy for breast cancer.
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Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer.
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Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk.
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Effects of amitraz on cytochrome P450-dependent monooxygenases and estrogenic activity in MCF-7 human breast cancer cells and immature female rats.
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Breast cancer in association with thyroid disorders.
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Analyses of bulky DNA adduct levels in human breast tissue and genetic polymorphisms of cytochromes P450 (CYPs), myeloperoxidase (MPO), quinone oxidoreductase (NQO1), and glutathione S-transferases (GSTs).
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Single nucleotide polymorphisms, metabolic activation and environmental carcinogenesis: why molecular epidemiologists should think about enzyme expression.
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Inhibition of carcinogen-induced rat mammary tumor growth and other estrogen-dependent responses by symmetrical dihalo-substituted analogs of diindolylmethane.
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Bone marrow changes induced by recombinant granulocyte colony-stimulating factor resembling metastatic carcinoma: distinction with cytochemical and immunohistochemical studies.
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The role of peroxidase-catalyzed activation of aromatic amines in breast cancer.
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Localization of the human estrogen-responsive finger protein (EEP) gene (ZNF147) within a YAC contig containing the myeloperoxidase (MPO) gene.
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Review of the effects of dietary fat on experimental mammary gland tumorigenesis: role of lipid peroxidation.
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Improved quantitation of HER-2/neu gene copy number in breast tumor-derived DNA samples.
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Neutrophil-Derived Myeloperoxidase Facilitates Both the Induction and Elicitation Phases of Contact Hypersensitivity.
Frontiers in immunology, , Volume: 11, 2020

Caffeic acid reduces cutaneous tumor necrosis factor alpha (TNF-α), IL-6 and IL-1β levels and ameliorates skin edema in acute and chronic model of cutaneous inflammation in mice.
Biological & pharmaceutical bulletin, , Volume: 37, Issue:3, 2014

Histopathological and immunohistochemical evaluation of nitrogen mustard-induced cutaneous effects in SKH-1 hairless and C57BL/6 mice.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, , Volume: 66, Issue:2-3, 2014

Topical anti-inflammatory potential of standardized pomegranate rind extract and ellagic acid in contact dermatitis.
Phytotherapy research : PTR, , Volume: 28, Issue:4, 2014

Absence of a p53 allele delays nitrogen mustard-induced early apoptosis and inflammation of murine skin.
Toxicology, , Sep-15, Volume: 311, Issue:3, 2013

Complementary methods for contact hypersensitivity (CHS) evaluation in mice.
Journal of immunological methods, , Jan-31, Volume: 387, Issue:1-2, 2013

Combretum leprosum Mart. (Combretaceae): potential as an antiproliferative and anti-inflammatory agent.
Journal of ethnopharmacology, , Jan-09, Volume: 145, Issue:1, 2013

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.
The Journal of clinical investigation, , Volume: 122, Issue:9, 2012

Systemic immunomodulatory effects of topical dinitrochlorobenzene (DNCB) in rats. Activity of peripheral blood polymorphonuclear cells.
Environmental toxicology and pharmacology, , Volume: 33, Issue:2, 2012

In vivo participation of nitric oxide in hyperproliferative epidermal phenomena in mice.
European journal of pharmacology, , Jul-15, Volume: 687, Issue:1-3, 2012

The involvement of TRPA1 channel activation in the inflammatory response evoked by topical application of cinnamaldehyde to mice.
Life sciences, , Jun-20, Volume: 88, Issue:25-26, 2011

2-Chloroethyl ethyl sulfide causes microvesication and inflammation-related histopathological changes in male hairless mouse skin.
Toxicology, , Apr-11, Volume: 282, Issue:3, 2011

Anti-inflammatory effects of Glehnia littoralis extract in acute and chronic cutaneous inflammation.
Immunopharmacology and immunotoxicology, , Volume: 32, Issue:4, 2010

Collared mice: a model to assess the effects of scratching.
Journal of dermatological science, , Volume: 57, Issue:1, 2010

Amphiregulin is not essential for induction of contact hypersensitivity.
Allergology international : official journal of the Japanese Society of Allergology, , Volume: 59, Issue:3, 2010

Bioluminescence imaging of myeloperoxidase activity in vivo.
Nature medicine, , Volume: 15, Issue:4, 2009

2,4-Dinitrofluorobenzene modifies cellular proteins and induces macrophage inflammatory protein-2 gene expression via reactive oxygen species production in RAW 264.7 cells.
Immunological investigations, , Volume: 38, Issue:2, 2009

Topically applied diterpenoids from Egletes viscosa (Asteraceae) attenuate the dermal inflammation in mouse ear induced by tetradecanoylphorbol 13-acetate- and oxazolone.
Biological & pharmaceutical bulletin, , Volume: 31, Issue:8, 2008

Curative effects of phosphodiesterase 4 inhibitors cilomilast, roflumilast, and rolipram in dermatitis mouse model.
Journal of dermatological science, , Volume: 51, Issue:3, 2008

Exposure and immunological determinants in a murine model for toluene diisocyanate (TDI) asthma.
Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 84, Issue:1, 2005

Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis.
British journal of pharmacology, , Volume: 143, Issue:5, 2004

Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity.
Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003

Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin.
International journal of oncology, , Volume: 21, Issue:6, 2002

Subcutaneous or oral administration of rhIL-11 modulated the contact hypersensitivity response.
Cytokine, , Volume: 12, Issue:12, 2000

Evaluation of the cutaneous anti-inflammatory activity of azaspiranes.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 47, Issue:2, 1998

Effect of topically applied cyclosporin A on arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation in mouse ear.
Inflammation, , Volume: 21, Issue:3, 1997

Susceptibility of 129/SvEv mice in two-stage carcinogenesis protocols to 12-O-tetradecanoylphorbol-13-acetate promotion.
Carcinogenesis, , Volume: 18, Issue:3, 1997

Zanhasaponins A and B, antiphospholipase A2 saponins from an antiinflammatory extract of Zanha africana root bark.
Journal of natural products, , Volume: 60, Issue:11, 1997

Delayed-type hypersensitivity in mast cell-deficient mice: dependence on platelets for expression of contact sensitivity.
Journal of immunology (Baltimore, Md. : 1950), , Jul-15, Volume: 157, Issue:2, 1996

Comparative evaluation of arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation.
Inflammation, , Volume: 17, Issue:6, 1993

Temporal infiltration of leukocyte subsets into mouse skin inflamed with phorbol ester.
Agents and actions, , Volume: 37, Issue:3-4, 1992

Non-promoting 12-deoxyphorbol 13-esters as potent inhibitors of phorbol 12-myristate 13-acetate-induced acute and chronic biological responses in CD-1 mouse skin.
Carcinogenesis, , Volume: 13, Issue:11, 1992

Lactoferrin, myeloperoxidase, lysozyme and eosinophil cationic protein in exudate in delayed type hypersensitivity.
Allergy, , Volume: 43, Issue:2, 1988

The role of neutrophils in tissue localized cell-mediated immunologic responses: I. The intensity of contact-type and delayed-type hypersensitivity responses may be influenced by the extent of extracellular matrix degradation by neutrophil proteases.
Regional immunology, , Volume: 1, Issue:3

Dermatophytosis and the immune response.
Journal of the American Academy of Dermatology, , Volume: 31, Issue:3 Pt 2, 1994

[Relation between erysipelas of the lower extremities and mycoses of the foot].
Vrachebnoe delo, , Issue:6, 1987

Promising Neutrophil-Associated Biomarkers in Lung Diseases of Patients with Antisynthetase Syndrome and Dermatomyositis.
Journal of immunology research, , Volume: 2022, 2022

High- density lipoprotein function is abnormal in idiopathic inflammatory myopathies.
Rheumatology (Oxford, England), , 11-01, Volume: 59, Issue:11, 2020

Increased levels of serum myeloperoxidase in patients with active rheumatoid arthritis.
Life sciences, , Nov-04, Volume: 117, Issue:1, 2014

Myeloperoxidase-antineutrophil cytoplasmic antibody-related crescentic glomerulonephritis after treatment for clinically amyopathic dermatomyositis: a coincidental combination or not?
Clinical and experimental nephrology, , Volume: 15, Issue:4, 2011

Immunoglobulin isotypes of anti-myeloperoxidase and anti-lactoferrin antibodies in patients with collagen diseases.
Journal of clinical immunology, , Volume: 20, Issue:4, 2000

Circulating myeloperoxidase and anti-myeloperoxidase antibody in patients with vasculitis.
Scandinavian journal of rheumatology, , Volume: 28, Issue:2, 1999

Brain Boron Level, DNA Content, and Myeloperoxidase Activity of Metformin-Treated Rats in Diabetes and Prostate Cancer Model.
Biological trace element research, , Volume: 200, Issue:3, 2022

Artificial intelligence based identification of the functional role of hirudin in diabetic erectile dysfunction treatment.
Pharmacological research, , Volume: 163, 2021

Impairment of renal steroidogenesis at the onset of diabetes.
Molecular and cellular endocrinology, , 03-15, Volume: 524, 2021

Modulatory effects of caffeic acid on purinergic and cholinergic systems and oxi-inflammatory parameters of streptozotocin-induced diabetic rats.
Life sciences, , Jul-15, Volume: 277, 2021

Improvement of Cutaneous Wound Healing via Topical Application of Heat-Killed
Nutrients, , Jul-31, Volume: 13, Issue:8, 2021

Ameliorative effect of AT2R and ACE2 activation on ischemic renal injury associated cardiac and hepatic dysfunction.
Environmental toxicology and pharmacology, , Volume: 80, 2020

Different roles of intracellular and extracellular reactive oxygen species of neutrophils in type 2 diabetic mice with invasive aspergillosis.
Immunobiology, , Volume: 225, Issue:5, 2020

Resolvin D1 promotes corneal epithelial wound healing and restoration of mechanical sensation in diabetic mice.
Molecular vision, , Volume: 24, 2018

Effect of melatonin on antioxidant capacity, ınflammation and apoptotic cell death in lung tissue of diabetic rats.
Acta cirurgica brasileira, , Volume: 33, Issue:4, 2018

Liraglutide Activates the Nrf2/HO-1 Antioxidant Pathway and Protects Brain Nerve Cells against Cerebral Ischemia in Diabetic Rats.
Computational intelligence and neuroscience, , Volume: 2018, 2018

A fluorescent homogeneous assay for myeloperoxidase measurement in biological samples. A positive correlation between myeloperoxidase-generated HOCl level and oxidative status in STZ-diabetic rats.
Talanta, , Aug-01, Volume: 170, 2017

Effect of Otostegia persica extract on ischemia/reperfusion induced renal damage in diabetic rats. A biochemical study.
Acta cirurgica brasileira, , Volume: 31, Issue:6, 2016

2-Morpholino-5-Phenyl-6H-1,3,4-Thiadiazine Corrects Metabolic Disorders during the Development of Alloxan Diabetes Mellitus in Rats.
Bulletin of experimental biology and medicine, , Volume: 162, Issue:1, 2016

Zinc supplementation ameliorates glycoprotein components and oxidative stress changes in the lung of streptozotocin diabetic rats.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, , Volume: 29, Issue:2, 2016

Nesfatin-1 improves oxidative skin injury in normoglycemic or hyperglycemic rats.
Peptides, , Volume: 78, 2016

Effect of photobiomodulation on ischemia/reperfusion-induced renal damage in diabetic rats.
Lasers in medical science, , Volume: 31, Issue:9, 2016

[The mediation of HIF-1α siRNA to the leukocyte adhesion and myeloid cell's activity in rat's retina under early stage of diabetic retinopathy].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology, , Volume: 51, Issue:5, 2015

H2S donors attenuate diabetic nephropathy in rats: Modulation of oxidant status and polyol pathway.
Pharmacological reports : PR, , Volume: 67, Issue:1, 2015

Assessment of anti-diabetic activity of an ethnopharmacological plant Nerium oleander through alloxan induced diabetes in mice.
Journal of ethnopharmacology, , Feb-23, Volume: 161, 2015

Hypoxia-induced acute lung injury is aggravated in streptozotocin diabetic mice.
Experimental lung research, , Volume: 41, Issue:3, 2015

Nitrative modifications of α-enolase in hepatic proteins from diabetic rats: the involvement of myeloperoxidase.
Chemico-biological interactions, , Sep-05, Volume: 220, 2014

Increased A3AR-dependent vasoconstriction in diabetic mice is promoted by myeloperoxidase.
Journal of cardiovascular pharmacology, , Volume: 64, Issue:5, 2014

Increased on oxidative brain injury in the diabetic rats following sepsis.
Synapse (New York, N.Y.), , Volume: 68, Issue:9, 2014

Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus.
BMC complementary and alternative medicine, , Jun-17, Volume: 14, 2014

8-O-acetyl shanzhiside methylester attenuates cerebral ischaemia/reperfusion injury through an anti-inflammatory mechanism in diabetic rats.
Basic & clinical pharmacology & toxicology, , Volume: 115, Issue:6, 2014

Novel CoQ10 antidiabetic mechanisms underlie its positive effect: modulation of insulin and adiponectine receptors, Tyrosine kinase, PI3K, glucose transporters, sRAGE and visfatin in insulin resistant/diabetic rats.
PloS one, , Volume: 9, Issue:2, 2014

Chard (Beta vulgaris L. var. cicla) extract ameliorates hyperglycemia by increasing GLUT2 through Akt2 and antioxidant defense in the liver of rats.
Acta histochemica, , Volume: 116, Issue:1, 2014

Cerebroprotective effect of resveratrol through antioxidant and anti-inflammatory effects in diabetic rats.
Naunyn-Schmiedeberg's archives of pharmacology, , Volume: 386, Issue:8, 2013

Neuroprotective effect of allopurinol and nimesulide against cerebral ischemic reperfusion injury in diabetic rats.
European review for medical and pharmacological sciences, , Volume: 17, Issue:2, 2013

Activation of peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) prevents endothelial dysfunction in type 1 diabetic rats.
Free radical biology & medicine, , Aug-15, Volume: 53, Issue:4, 2012

Effects of diabetes on cytokines and oxidative organ injury in a rat model of sepsis.
Cellular and molecular biology (Noisy-le-Grand, France), , Feb-16, Volume: 58 Suppl, 2012

The microalga Spirulina platensis presents anti-inflammatory action as well as hypoglycemic and hypolipidemic properties in diabetic rats.
Journal of complementary & integrative medicine, , Aug-10, Volume: 9, 2012

Effects of diabetes and ovariectomy on rat hippocampus (a biochemical and stereological study).
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, , Volume: 28, Issue:3, 2012

Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes.
Regulatory peptides, , Jan-17, Volume: 166, Issue:1-3, 2011

The effects of diabetes and/or polymicrobial sepsis on the status of antioxidant enzymes and pro-inflammatory cytokines on heart, liver, and lung of ovariectomized rats.
The Journal of surgical research, , Volume: 169, Issue:1, 2011

Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3β dependent pathway in experimental diabetic cardiomyopathy.
Cardiovascular diabetology, , Jan-13, Volume: 10, 2011

Oral administration of skin gelatin isolated from Chum salmon (Oncorhynchus keta) enhances wound healing in diabetic rats.
Marine drugs, , Volume: 9, Issue:5, 2011

Exendin-4 improves hepatocyte injury by decreasing proliferation through blocking NGF/TrkA in diabetic mice.
Peptides, , Volume: 32, Issue:2, 2011

The protective role of hydrogen sulfide in myocardial ischemia-reperfusion-induced injury in diabetic rats.
International journal of cardiology, , Oct-20, Volume: 152, Issue:2, 2011

Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats.
Free radical biology & medicine, , Jan-15, Volume: 50, Issue:2, 2011

[Diabetes mellitus ulcers treatment with Bletilla striata polysaccharide].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, , Volume: 36, Issue:11, 2011

Influence of esomeprazole on hypoglycemic activity of oral antidiabetic agents in rats and rabbits.
Molecular and cellular biochemistry, , Volume: 354, Issue:1-2, 2011

Pectin from Passiflora edulis shows anti-inflammatory action as well as hypoglycemic and hypotriglyceridemic properties in diabetic rats.
Journal of medicinal food, , Volume: 14, Issue:10, 2011

Effects of diabetes mellitus on the rat liver during the postmenopausal period.
Journal of molecular histology, , Volume: 42, Issue:3, 2011

Fenofibrate treatment enhances antioxidant status and attenuates endothelial dysfunction in streptozotocin-induced diabetic rats.
Experimental diabetes research, , Volume: 2010, 2010

Inability of legumes to reverse diabetic-induced nephropathy in rats despite improvement in blood glucose and antioxidant status.
Journal of medicinal food, , Volume: 13, Issue:1, 2010

Diode laser decreases the activity of catalase on submandibular glands of diabetic rats.
Photomedicine and laser surgery, , Volume: 28, Issue:1, 2010

Effect of diode laser on enzymatic activity of parotid glands of diabetic rats.
Lasers in medical science, , Volume: 24, Issue:4, 2009

Sodium tungstate on some biochemical parameters of the parotid salivary gland of streptozotocin-induced diabetic rats: a short-term study.
Biological trace element research, , Volume: 127, Issue:2, 2009

Aspirin prevents diabetic oxidative changes in rat lacrimal gland structure and function.
Endocrine, , Volume: 35, Issue:2, 2009

The effect of experimental diabetes on the circadian pattern of adenosine deaminase and myeloperoxidase activities in rat liver.
General physiology and biophysics, , Volume: 27, Issue:1, 2008

[Intervention effect of ganoderma lucidum spores on the changes of XOD, MPO and SDH in the testis tissue of NIDDM rats].
Zhonghua nan ke xue = National journal of andrology, , Volume: 14, Issue:9, 2008

Melatonin treatment against remote organ injury induced by renal ischemia reperfusion injury in diabetes mellitus.
Archives of pharmacal research, , Volume: 31, Issue:6, 2008

Protection of testicular dysfunctions by MTEC, a formulated herbal drug, in streptozotocin induced diabetic rat.
Biological & pharmaceutical bulletin, , Volume: 30, Issue:1, 2007

Effect of dietary fish oil supplementation on cellular adhesion molecule expression and tissue myeloperoxidase activity in diabetic mice with sepsis.
The British journal of nutrition, , Volume: 97, Issue:4, 2007

Simvastatin pretreatment reduces the severity of limb ischemia in an experimental diabetes model.
Journal of vascular surgery, , Volume: 45, Issue:3, 2007

Extra-pancreatic insulin production in RAt lachrymal gland after streptozotocin-induced islet beta-cells destruction.
Biochimica et biophysica acta, , Volume: 1770, Issue:8, 2007

Diabetes and its effects on dental pulp.
Journal of oral science, , Volume: 48, Issue:4, 2006

17beta-estradiol potentiates ischemia-reperfusion injury in diabetic ovariectomized female rats.
Brain research, , Aug-30, Volume: 1054, Issue:2, 2005

Gut permeability and intestinal mucins, invertase, and peroxidase in control and diabetes-prone BB rats fed either a protective or a diabetogenic diet.
Digestive diseases and sciences, , Volume: 50, Issue:2, 2005

Raxofelast, a hydrophilic vitamin E-like antioxidant, stimulates wound healing in genetically diabetic mice.
Surgery, , Volume: 129, Issue:4, 2001

Protein aging by carboxymethylation of lysines generates sites for divalent metal and redox active copper binding: relevance to diseases of glycoxidative stress.
Biochemical and biophysical research communications, , Jul-05, Volume: 260, Issue:2, 1999

Early manifestations of nephropathy in alloxan-treated rats.
Renal failure, , Volume: 20, Issue:4, 1998

Effects of streptozocin-induced diabetes on sympathetic and parasympathetic stimulation of parotid salivary gland function in rats.
Diabetes, , Volume: 38, Issue:11, 1989

Parotid gland function in streptozotocin-diabetic rats.
Journal of dental research, , Volume: 66, Issue:2, 1987

Depression of estrogen-induced uterine peroxidase in alloxan-diabetic rats.
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Changes in the enzymatic composition of liver. II. Influence of hormones on picolinic carboxylase and tryptophan peroxidase.
The Journal of biological chemistry, , Volume: 232, Issue:1, 1958

Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats.
Indian journal of pharmacology, , Volume: 46, Issue:6

The relation zinc-lipidic peroxidation in experimental diabetes mellitus.
Romanian journal of physiology : physiological sciences, , Volume: 30, Issue:3-4

NETosis in Long-Term Type 1 Diabetes Mellitus and Its Link to Coronary Artery Disease.
Frontiers in immunology, , Volume: 12, 2021

Improvement of Cutaneous Wound Healing via Topical Application of Heat-Killed
Nutrients, , Jul-31, Volume: 13, Issue:8, 2021

Modulatory effects of caffeic acid on purinergic and cholinergic systems and oxi-inflammatory parameters of streptozotocin-induced diabetic rats.
Life sciences, , Jul-15, Volume: 277, 2021

Gluten intake and risk of thyroid peroxidase autoantibodies in the Diabetes Autoimmunity Study In the Young (DAISY).
Endocrine, , Volume: 70, Issue:2, 2020

Elevated Leukocyte Azurophilic Enzymes in Human Diabetic Ketoacidosis Plasma Degrade Cerebrovascular Endothelial Junctional Proteins.
Critical care medicine, , Volume: 44, Issue:9, 2016

Assessment of anti-diabetic activity of an ethnopharmacological plant Nerium oleander through alloxan induced diabetes in mice.
Journal of ethnopharmacology, , Feb-23, Volume: 161, 2015

Hypoxia-induced acute lung injury is aggravated in streptozotocin diabetic mice.
Experimental lung research, , Volume: 41, Issue:3, 2015

Paraoxonase lactonase activity, inflammation and antioxidant status in plasma of patients with type 1 diabetes mellitus.
The Journal of international medical research, , Volume: 42, Issue:2, 2014

Eosinophils from patients with type 1 diabetes mellitus express high level of myeloid alpha-defensins and myeloperoxidase.
Cellular immunology, , Volume: 273, Issue:2, 2012

Altered inflammatory, oxidative, and metabolic responses to exercise in pediatric obesity and type 1 diabetes.
Pediatric diabetes, , Volume: 12, Issue:5, 2011

Discovery and validation of serum protein changes in type 1 diabetes patients using high throughput two dimensional liquid chromatography-mass spectrometry and immunoassays.
Molecular & cellular proteomics : MCP, , Volume: 10, Issue:11, 2011

[A case of slowly progressive type 1 diabetes mellitus developing myeloperoxidase-specific anti-neutrophil cytoplasmic antibody-associated vasculitis with hypertrophic pachymeningitis manifesting as multiple cranial nerve palsy].
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, , Volume: 34, Issue:6, 2011

Effect of long- and short-term treatments with pravastatin on diabetes mellitus and pancreatic fibrosis in the Otsuka-Long-Evans-Tokushima fatty rat.
British journal of pharmacology, , Jan-01, Volume: 159, Issue:2, 2010

Frequency of anti-glutamic acid decarboxylase and anti-thyroperoxidase autoantibodies in siblings of patients with diabetes diagnosed in adult life.
International journal of clinical practice, , Volume: 63, Issue:3, 2009

Arterial stiffness, carotid artery intima-media thickness and plasma myeloperoxidase level in children with type 1 diabetes.
Diabetes research and clinical practice, , Volume: 84, Issue:2, 2009

Invertase, maltase, lactase, and peroxidase activities in duodenum of BB rats.
Endocrine, , Volume: 19, Issue:3, 2002

The evaluation of thyroid and islet autoantibodies in type 1 diabetes mellitus.
Sbornik lekarsky, , Volume: 100, Issue:3, 1999

Detection of anti-myeloperoxidase antibodies in the serum of patients with type 1 diabetes mellitus.
Acta diabetologica, , Volume: 33, Issue:2, 1996

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[System of lipid peroxidation--antioxidant protection and the role of its disorders in the pathogenesis of diabetes mellitus and angiopathy].
Problemy endokrinologii, , Volume: 39, Issue:1

Endocrine autoimmunity in young patients with juvenile chronic arthritis.
Clinical and experimental rheumatology, , Volume: 20, Issue:4

Myeloperoxidase amplified high glucose-induced endothelial dysfunction in vasculature: Role of NADPH oxidase and hypochlorous acid.
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Circulating Neutrophil Extracellular Trap Levels in Well-Controlled Type 2 Diabetes and Pathway Involved in Their Formation Induced by High-Dose Glucose.
Pathobiology : journal of immunopathology, molecular and cellular biology, , Volume: 83, Issue:5, 2016

Oxidized HDL and LDL in adolescents with type 2 diabetes compared to normal weight and obese peers.
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Trans-vessel gradient of myeloperoxidase in coronary artery disease.
European journal of clinical investigation, , Volume: 43, Issue:9, 2013

Genotype-dependent impairment of hemoglobin clearance increases oxidative and inflammatory response in human diabetic atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 32, Issue:11, 2012

Activation of peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) prevents endothelial dysfunction in type 1 diabetic rats.
Free radical biology & medicine, , Aug-15, Volume: 53, Issue:4, 2012

Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy.
Circulation, , Jan-05, Volume: 121, Issue:1, 2010

Mass spectrometric quantification of amino acid oxidation products identifies oxidative mechanisms of diabetic end-organ damage.
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Leukocyte-derived myeloperoxidase amplifies high-glucose--induced endothelial dysfunction through interaction with high-glucose--stimulated, vascular non--leukocyte-derived reactive oxygen species.
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[System of lipid peroxidation--antioxidant protection and the role of its disorders in the pathogenesis of diabetes mellitus and angiopathy].
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H2S donors attenuate diabetic nephropathy in rats: Modulation of oxidant status and polyol pathway.
Pharmacological reports : PR, , Volume: 67, Issue:1, 2015

Predictive value of serum myeloperoxidase activity for thrombosis of arteriovenous fistulas.
Hemodialysis international. International Symposium on Home Hemodialysis, , Volume: 18, Issue:3, 2014

Association of myeloperoxidase G-463A gene polymorphism with diabetic nephropathy in Japanese type 2 diabetic subjects.
Endocrine journal, , Volume: 60, Issue:4, 2013

Is myeloperoxidase a key component in the ROS-induced vascular damage related to nephropathy in type 2 diabetes?
Antioxidants & redox signaling, , Nov-01, Volume: 19, Issue:13, 2013

Inability of legumes to reverse diabetic-induced nephropathy in rats despite improvement in blood glucose and antioxidant status.
Journal of medicinal food, , Volume: 13, Issue:1, 2010

Statin treatment and diabetes affect myeloperoxidase activity in maintenance hemodialysis patients.
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Mesangial accumulation of GA-pyridine, a novel glycolaldehyde-derived AGE, in human renal disease.
Kidney international, , Volume: 68, Issue:2, 2005

Genetic determination of TNF and myeloperoxidase production in dialyzed patients with diabetic nephropathy.
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A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients.
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Myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis superimposed on biopsy-proven diabetic nephrosclerosis.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 39, Issue:1, 2002

Simultaneous occurrence of diabetic glomerulosclerosis, IgA nephropathy, crescentic glomerulonephritis, and myeloperoxidase-antineutrophil cytoplasmic antibody seropositivity in a Chinese patient.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 40, Issue:4, 2002

Early manifestations of nephropathy in alloxan-treated rats.
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Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats.
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The Association Between Fecal Biomarkers of Environmental Enteropathy and Rotavirus Vaccine Response in Nicaraguan Infants.
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Fecal Markers of Environmental Enteropathy and Subsequent Growth in Bangladeshi Children.
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Science to practice: can an enzyme-sensitive MR contrast agent be used to image inflammation in aneurysms?
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[Lymphocyte and neutrophil cytochemistry in the dynamics of different forms of diphtheria in adults].
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Subclinical inflammation with increased neutrophil activity in healthy twin siblings reflect environmental influence in the pathogenesis of inflammatory bowel disease.
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Recognizing Central Nervous System Involvement as a Progressive Feature of Microscopic Polyangiitis: A Diagnostic Dilemma.
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[Effect of UV radiation and the autotransfusion of UV-irradiated blood on the content of cationic proteins in the neutrophilic granulocytes of calves].
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A case of pulmonary arteritis with stenosis of the main pulmonary arteries with positive myeloperoxidase-antineutrophil cytoplasmic autoantibodies.
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Characteristics of Chinese patients with Wegener's granulomatosis with anti-myeloperoxidase autoantibodies.
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Effects of an anti-inflammatory peptide (antiflammin 2) on cell influx, eicosanoid biosynthesis and oedema formation by arachidonic acid and tetradecanoyl phorbol dermal application.
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Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by geniposide.
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Anti-neutrophil cytoplasmic antibodies in echinococcus granulosus hydatid disease.
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Anti-neutrophil cytoplasmic antibodies in echinococcus granulosus hydatid disease.
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The Role of Oxidative Stress in the Clinical Manifestations of Childhood Asthma.
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Serum inflammatory markers and effects of age and tobacco smoke exposure in young non-asthmatic children.
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Inflammation markers and symptom activity in children with bronchial asthma. Influence of atopy and eczema.
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Lymphatic diversion prevents myocardial edema following mesenteric ischemia/reperfusion.
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Serum levels of eosinophil cationic protein, eosinophil-derived neurotoxin and myeloperoxidase in infections with filariae and schistosomes.
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Neutrophil myeloperoxidase measurement uncovers masked megaloblastic anemia.
Blood, , Sep-01, Volume: 76, Issue:5, 1990

Microparticle production, neutrophil activation, and intravascular bubbles following open-water SCUBA diving.
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N-acetylcysteine attenuates acute lung injury induced by fat embolism.
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Triolein increases microvascular permeability in isolated perfused rabbit lungs: role of neutrophils.
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Markers of acute coronary syndrome in emergency room.
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Pulmonary-renal syndrome in a newborn with placental transmission of ANCAs.
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Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury.
Neuropharmacology, , 08-01, Volume: 172, 2020

MRI of Iron Oxide Nanoparticles and Myeloperoxidase Activity Links Inflammation to Brain Edema in Experimental Cerebral Malaria.
Radiology, , Volume: 290, Issue:2, 2019

Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice.
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Cerebellopathy secondary to anti-peroxidase antibody-mediated toxicity. A special case of Hashimoto encephalopathy.
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First description of enhanced expression of glia maturation factor-beta in experimental toxoplasmic encephalitis.
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Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology.
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Neuroinflammatory response to experimental stroke is inhibited by eriodictyol.
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Foxo1-mediated inflammatory response after cerebral hemorrhage in rats.
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Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.
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Systemic responses following brain injuries and inflammatory process activation induced by a neurotoxin of Androctonus scorpion venom.
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Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury.
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Ulinastatin attenuates oxidation, inflammation and neural apoptosis in the cerebral cortex of adult rats with ventricular fibrillation after cardiopulmonary resuscitation.
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Immune following suppression mesenchymal stem cell transplantation in the ischemic brain is mediated by TGF-β.
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Immunoglobulin G (IgG) attenuates neuroinflammation and improves neurobehavioral recovery after cervical spinal cord injury.
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Opsoclonus as a manifestation of Hashimoto's encephalopathy.
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Toll-like receptor 4 is involved in ischemic tolerance of postconditioning in hippocampus of tree shrews to thrombotic cerebral ischemia.
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Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action.
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Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis.
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Nuclear factor-kappaB activation and postischemic inflammation are suppressed in CD36-null mice after middle cerebral artery occlusion.
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Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury.
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Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke.
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Attenuation of brain inflammatory response after focal cerebral ischemia/reperfusion with Xuesaitong injection in rats.
Chinese journal of integrative medicine, , Volume: 12, Issue:3, 2006

Characterization of a rat model to study acute neuroinflammation on histopathological, biochemical and functional outcomes.
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Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist.
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Effects of hypothermia on thrombin-induced brain edema formation.
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Importance of posttraumatic hypothermia and hyperthermia on the inflammatory response after fluid percussion brain injury: biochemical and immunocytochemical studies.
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Degradation of Japanese encephalitis virus by neutrophils.
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Development of a model of Saint Louis encephalitis infection and disease in mice.
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Myeloperoxidase Molecular MRI Reveals Synergistic Combination Therapy in Murine Experimental Autoimmune Neuroinflammation.
Radiology, , Volume: 293, Issue:1, 2019

Multimodal Molecular Imaging Demonstrates Myeloperoxidase Regulation of Matrix Metalloproteinase Activity in Neuroinflammation.
Molecular neurobiology, , Volume: 56, Issue:2, 2019

Inhibition of myeloperoxidase by N-acetyl lysyltyrosylcysteine amide reduces experimental autoimmune encephalomyelitis-induced injury and promotes oligodendrocyte regeneration and neurogenesis in a murine model of progressive multiple sclerosis.
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The neuroprotective effect of mesenchymal stem cells on an experimentally induced model for multiple sclerosis in mice.
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Gelsolin decreases actin toxicity and inflammation in murine multiple sclerosis.
Journal of neuroimmunology, , Oct-15, Volume: 287, 2015

Multiple sclerosis: myeloperoxidase immunoradiology improves detection of acute and chronic disease in experimental model.
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Neutrophils amplify autoimmune central nervous system infiltrates by maturing local APCs.
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Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target.
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Upregulation of CSPG3 accompanies neuronal progenitor proliferation and migration in EAE.
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Chronic immobilisation stress ameliorates clinical score and neuroinflammation in a MOG-induced EAE in Dark Agouti rats: mechanisms implicated.
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Hippocampal neurodegeneration in experimental autoimmune encephalomyelitis (EAE): potential role of inflammation activated myeloperoxidase.
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Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.
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Mice lacking myeloperoxidase are more susceptible to experimental autoimmune encephalomyelitis.
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The clinical pattern differentiates ANCA-positive infective endocarditis patients from ANCA-associated vasculitis patients: a 23 years' retrospective cohort study in China and follow-ups.
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Prolonged infections associated with antineutrophil cytoplasmic antibodies specific to proteinase 3 and myeloperoxidase: diagnostic and therapeutic challenge.
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Human natural tumor necrosis factor alpha induces multiple endocrine and hematologic disorders in rats.
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Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats.
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Evaluation of Total, Active, and Specific Myeloperoxidase Levels in Women with and without Endometriosis.
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Myeloperoxidase as a Potential Target in Women With Endometriosis Undergoing IVF.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 68, Issue:7, 2014

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The Journal of veterinary medical science, , Feb-20, Volume: 80, Issue:2, 2018

IFN-τ Plays an Anti-Inflammatory Role in Staphylococcus aureus-Induced Endometritis in Mice Through the Suppression of NF-κB Pathway and MMP9 Expression.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, , Volume: 37, Issue:2, 2017

Berberine hydrochloride attenuates lipopolysaccharide-induced endometritis in mice by suppressing activation of NF-κB signal pathway.
International immunopharmacology, , Volume: 24, Issue:1, 2015

High concentrations of myeloperoxidase in the equine uterus as an indicator of endometritis.
Theriogenology, , Apr-15, Volume: 81, Issue:7, 2014

Neutrophil extracellular traps formation by bacteria causing endometritis in the mare.
Journal of reproductive immunology, , Volume: 106, 2014

Antenatal betamethasone attenuates intrauterine infection-aggravated hyperoxia-induced lung injury in neonatal rats.
Pediatric research, , Volume: 73, Issue:6, 2013

Selective CB2 up-regulation in women affected by endometrial inflammation.
Journal of cellular and molecular medicine, , Volume: 12, Issue:2, 2008

Experimental endometriosis in the rat is correlated with colonic motor function alterations but not with bacterial load.
Reproductive sciences (Thousand Oaks, Calif.), , Volume: 14, Issue:8, 2007

Neutrophil function and energy status in Holstein cows with uterine health disorders.
Veterinary immunology and immunopathology, , Sep-15, Volume: 113, Issue:1-2, 2006

Innate immunity prevents tissue invasion by Entamoeba histolytica.
Canadian journal of microbiology, , Volume: 54, Issue:12, 2008

Amebic infection in the human colon induces cyclooxygenase-2.
Infection and immunity, , Volume: 69, Issue:5, 2001

A prebiotic effect of Ecklonia cava on the growth and mortality of olive flounder infected with pathogenic bacteria.
Fish & shellfish immunology, , Volume: 51, 2016

Identification of a myeloperoxidase-like ortholog from rock bream (Oplegnathus fasciatus), deciphering its transcriptional responses to induced pathogen stress.
Fish & shellfish immunology, , Volume: 45, Issue:2, 2015

Effect of Edwardsiella tarda immunization on systemic immune response, mucosal immune response and protection in catla (Catla catla).
Veterinary research communications, , Volume: 38, Issue:2, 2014

Changes of serum myeloperoxidase and nitric oxide in the early stage of Edwardsiella ictaluri infection in channel catfish, Ictalurus punctatus (Rafinesque).
Journal of fish diseases, , Volume: 36, Issue:4, 2013

Intestinal epithelial CD98 directly modulates the innate host response to enteric bacterial pathogens.
Infection and immunity, , Volume: 81, Issue:3, 2013

Distinct compartmentalization of NF-κB activity in crypt and crypt-denuded lamina propria precedes and accompanies hyperplasia and/or colitis following bacterial infection.
Infection and immunity, , Volume: 80, Issue:2, 2012

Modulation of hepatic cytochrome P450s by Citrobacter rodentium infection in interleukin-6- and interferon-{gamma}-null mice.
The Journal of pharmacology and experimental therapeutics, , Volume: 335, Issue:2, 2010

Saccharomyces boulardii ameliorates Citrobacter rodentium-induced colitis through actions on bacterial virulence factors.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 294, Issue:1, 2008

Crucial role of the melanocortin receptor MC1R in experimental colitis.
Gut, , Volume: 55, Issue:10, 2006

Citrobacter rodentium infection causes iNOS-independent intestinal epithelial dysfunction in mice.
Canadian journal of physiology and pharmacology, , Volume: 84, Issue:12, 2006

Positive bacterial culture of semen from infertile men with asymptomatic leukocytospermia.
International journal of fertility and women's medicine, , Volume: 47, Issue:6

The role of local and systemic cytokines in patients infected with Clostridium difficile.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, , Volume: 65, Issue:5, 2014

Effect of Lactobacillus acidophilus & epidermal growth factor on experimentally induced Clostridium difficile infection.
The Indian journal of medical research, , Volume: 133, 2011

Effect of biotherapeutics on cyclosporin-induced Clostridium difficile infection in mice.
Journal of gastroenterology and hepatology, , Volume: 25, Issue:4, 2010

Comparative role of antibiotic and proton pump inhibitor in experimental Clostridium difficile infection in mice.
Microbiology and immunology, , Volume: 51, Issue:12, 2007

Essential involvement of IFN-gamma in Clostridium difficile toxin A-induced enteritis.
Journal of immunology (Baltimore, Md. : 1950), , Mar-01, Volume: 172, Issue:5, 2004

Extrinsic surgical denervation inhibits Clostridium difficile toxin A-induced enteritis in rats.
Neuroscience letters, , Oct-06, Volume: 292, Issue:2, 2000

A model of intestinal ischemia in the neonatal rat utilizing superior mesenteric artery occlusion and intraluminal platelet-activating factor.
The Journal of surgical research, , Volume: 58, Issue:6, 1995

Mucosal permeability after subclinical intestinal ischemia-reperfusion injury: an exploration of possible mechanisms.
Journal of pediatric surgery, , Volume: 30, Issue:4, 1995

Inflammatory enzyme composition of the neonatal rat intestine: implications for susceptibility to ischemia.
Journal of pediatric surgery, , Volume: 28, Issue:6, 1993

Endogenous nitric oxide protects against platelet-activating factor-induced bowel injury in the rat.
Pediatric research, , Volume: 34, Issue:2, 1993

Nitric oxide release in response to gut injury.
Scandinavian journal of gastroenterology, , Volume: 28, Issue:2, 1993

Inactivation of Clostridium difficile cytotoxin by the neutrophil myeloperoxidase system.
The Journal of infectious diseases, , Volume: 149, Issue:2, 1984

Particle-induced myeloperoxidase release in serially diluted whole blood quantifies the number and the phagocytic activity of blood neutrophils and opsonization capacity of plasma.
Luminescence : the journal of biological and chemical luminescence, , Volume: 21, Issue:3

Torasemide-induced Vascular Purpura in the Course of Eosinophilic Granulomatosis with Polyangiitis.
Acta dermatovenerologica Croatica : ADC, , Volume: 30, Issue:2, 2022

Eosinophilic granulomatosis with polyangiitis presenting with myositis: case based review.
Rheumatology international, , Volume: 40, Issue:7, 2020

Decrease in MPO-ANCA after administration of benralizumab in eosinophilic granulomatosis with polyangiitis.
Allergology international : official journal of the Japanese Society of Allergology, , Volume: 68, Issue:4, 2019

Recognizing Central Nervous System Involvement as a Progressive Feature of Microscopic Polyangiitis: A Diagnostic Dilemma.
The American journal of medicine, , Volume: 132, Issue:9, 2019

Case 32-2017. A 64-Year-Old Man with Dyspnea, Wheezing, Headache, Cough, and Night Sweats.
The New England journal of medicine, , 10-19, Volume: 377, Issue:16, 2017

Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis.
Inflammatory bowel diseases, , Volume: 21, Issue:10, 2015

Clinicopathological and immunohistochemical analysis of 19 cases of oral eosinophilic ulcers.
Oral surgery, oral medicine, oral pathology and oral radiology, , Volume: 115, Issue:4, 2013

Effects of exposure to nanoparticle-rich or -depleted diesel exhaust on allergic pathophysiology in the murine lung.
The Journal of toxicological sciences, , Volume: 38, Issue:1, 2013

Churg-Strauss syndrome presenting with acute renal insufficiency accompanied by eosinophilic tubulointerstitial nephritis.
Internal medicine (Tokyo, Japan), , Volume: 51, Issue:12, 2012

Systemic vasculitis in a patient with atopic dermatitis, eosinophilia, pulmonary-renal syndrome, and positive myeloperoxidase antibody: a classification conundrum.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, , Volume: 18, Issue:1, 2012

Lung immunoreactivity and airway inflammation: their assessment after scorpion envenomation.
Inflammation, , Volume: 35, Issue:2, 2012

Eosinophil degranulation is more important than eosinophilia in identifying asthma in chronic cough.
The Journal of asthma : official journal of the Association for the Care of Asthma, , Volume: 48, Issue:10, 2011

Eosinophilic venulitis of colon presenting as ileocecal mass.
Annals of clinical and laboratory science, ,Fall, Volume: 41, Issue:4, 2011

Arginase activity differs with allergen in the effector phase of ovalbumin- versus trimellitic anhydride-induced asthma.
Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 88, Issue:2, 2005

Eosinophilic airway inflammation as an underlying mechanism of undiagnosed prolonged cough in primary healthcare patients.
Respiratory medicine, , Volume: 96, Issue:1, 2002

Cytochemical demonstration of methanol-resistant peroxidase in eosinophils using a combined method of wright stain and benzidine base.
International journal of hematology, , Volume: 76, Issue:4, 2002

Eosinophilia in duck embryos induced by an apathogenic strain of duck enteritis virus.
Journal of comparative pathology, , Volume: 124, Issue:4, 2001

MPO-ANCA-positive crescentic necrotizing glomerulonephritis and tubulointerstitial nephritis with renal eosinophilic infiltration and peripheral blood eosinophilia.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 31, Issue:6, 1998

[Eosinophilic meningoencephalitis in a case of rheumatoid arthritis].
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, , Volume: 21, Issue:5, 1998

Role of particulate antigens of Aspergillus in murine eosinophilia.
International archives of allergy and immunology, , Volume: 112, Issue:3, 1997

A new murine model of pulmonary eosinophilic hypersensitivity: contribution to experimental asthma.
The Journal of allergy and clinical immunology, , Volume: 100, Issue:3, 1997

Influence of endogenous cortisol on eosinophil function in sensitized pigs: direct measurements of eosinophil peroxidase.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 26, Issue:4, 1996

BAL neutrophilia in asthmatic patients. A by-product of eosinophil recruitment?
Chest, , Volume: 110, Issue:5, 1996

Serum levels of eosinophil cationic protein, eosinophil-derived neurotoxin and myeloperoxidase in infections with filariae and schistosomes.
Acta tropica, , Dec-16, Volume: 62, Issue:3, 1996

Eosinophil peroxidase deficiency in New Zealand white mice.
International archives of allergy and immunology, , Volume: 111, Issue:1, 1996

Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 18-1992. Asthma, peripheral neuropathy, and eosinophilia in a 52-year-old man.
The New England journal of medicine, , Apr-30, Volume: 326, Issue:18, 1992

Blood eosinophil number and activity in relation to lung function in patients with asthma and with eosinophilia.
The Journal of allergy and clinical immunology, , Volume: 87, Issue:2, 1991

Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) and peroxidase in macrophages, eosinophils, and extracellular matrix of the skin in the hypereosinophilic syndrome.
Laboratory investigation; a journal of technical methods and pathology, , Volume: 62, Issue:5, 1990

Experimental eosinophilia and inflammation--the effect of various inflammatory mediators and chemoattractants.
Experimental pathology, , Volume: 29, Issue:3, 1986

Purification of eosinophil peroxidase and studies of biosynthesis and processing in human marrow cells.
Blood, , Volume: 66, Issue:5, 1985

Mechanisms for eosinophil degranulation; release of the eosinophil cationic protein.
Immunology, , Volume: 51, Issue:1, 1984

Some enzymatic characteristics of eosinophil peroxidase from patients with eosinophilia and from healthy donors.
Infection and immunity, , Volume: 32, Issue:2, 1981

Arginine-rich cationic proteins of human eosinophil granules: comparison of the constituents of eosinophilic and neutrophilic leukocytes.
Laboratory investigation; a journal of technical methods and pathology, , Volume: 36, Issue:5, 1977

Churg-Strauss syndrome: clinical presentation, antineutrophil cytoplasmic antibodies, and leukotriene receptor antagonists.
The American journal of medicine, , Volume: 115, Issue:4, 2003

Increase of leucocyte-derived extracellular traps (ETs) in semen samples from human acute epididymitis patients-a pilot study.
Journal of assisted reproduction and genetics, , Volume: 37, Issue:9, 2020

Oxidative and antioxidative status in the testes of rats with acute epididymitis.
Urologia internationalis, , Volume: 76, Issue:4, 2006

The protective effect of vitamin U on pentylenetetrazole-induced brain damage in rats.
Journal of biochemical and molecular toxicology, , Volume: 36, Issue:10, 2022

Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis.
Proceedings of the National Academy of Sciences of the United States of America, , 05-12, Volume: 117, Issue:19, 2020

Myeloperoxidase Nuclear Imaging for Epileptogenesis.
Radiology, , Volume: 278, Issue:3, 2016

Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice.
Seizure, , Volume: 16, Issue:8, 2007

Co-administration of acetyl-11-keto-beta-boswellic acid, a specific 5-lipoxygenase inhibitor, potentiates the protective effect of COX-2 inhibitors in kainic acid-induced neurotoxicity in mice.
Pharmacology, , Volume: 79, Issue:1, 2007

Activation of the phagocyte NADPH oxidase/NOX2 and myeloperoxidase in the mouse brain during pilocarpine-induced temporal lobe epilepsy and inhibition by ketamine.
Inflammopharmacology, , Volume: 28, Issue:2, 2020

Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury.
Neuropharmacology, , 08-01, Volume: 172, 2020

First reported case of ANCA-associated vasculitis induced by oxaliplatin, capecitabine, and trastuzumab.
Renal failure, , Volume: 45, Issue:2, 2023

The complexity of classifying ANCA-associated small-vessel vasculitis in actual clinical practice: data from a multicenter retrospective survey.
Rheumatology international, , Volume: 40, Issue:2, 2020

[Relation between erysipelas of the lower extremities and mycoses of the foot].
Vrachebnoe delo, , Issue:6, 1987

Automated cytochemical differential leucocyte count in patients hospitalized with acute bacterial infections.
Scandinavian journal of infectious diseases, , Volume: 17, Issue:2, 1985

Myelodysplastic/myeloproliferative disease with erythropoietic hyperplasia (erythroid preleukemia) and the unique translocation (8;9)(p23;p24): first description of a case.
Human pathology, , Volume: 36, Issue:10, 2005

Bone marrow architecture in acute myeloid/erythroid leukaemia.
British journal of haematology, , Volume: 126, Issue:1, 2004

Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase.
The Journal of biological chemistry, , Apr-19, Volume: 271, Issue:16, 1996

Identification and characterization of the human myeloperoxidase promoter.
Leukemia, , Volume: 9, Issue:5, 1995

Inhibition of the differentiation of human myeloid cell lines by redox changes induced through glutathione depletion.
The Biochemical journal, , Aug-01, Volume: 301 ( Pt 3), 1994

Establishment of a new cell line with the characteristics of a multipotential progenitor from a patient with chronic myelogenous leukemia in early erythroblastic crisis.
Leukemia, , Volume: 8, Issue:1, 1994

The monocytic cell line SKM-1 strongly expresses the myeloperoxidase gene.
Leukemia, , Volume: 6, Issue:12, 1992

Childhood undifferentiated leukemia with early erythroid markers and c-myb duplication.
Leukemia, , Volume: 5, Issue:2, 1991

Identification of circulating micromegakaryocytes in a case of erythroleukemia.
Cancer, , Jun-15, Volume: 53, Issue:12, 1984

Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
British journal of haematology, , Volume: 33, Issue:4, 1976

Depressed neutrophil-mediated tumor cell cytotoxicity in subjects affected by hereditary myeloperoxidase deficiency and secondary neoplasia.
Haematologica, , Volume: 73, Issue:5

The possible neurobehavioral protective effects of natural antioxidant against phototoxicity attenuation of antimicrobial quinolone group in rats.
Journal of biochemical and molecular toxicology, , Volume: 34, Issue:7, 2020

Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection.
Scientific reports, , 01-14, Volume: 9, Issue:1, 2019

A novel strategy for antimicrobial agent: role of exogenous carbon monoxide on suppressing Escherichia coli vitality and toxicity.
Pakistan journal of pharmaceutical sciences, , Volume: 28, Issue:1 Suppl, 2015

Intravesical hyaluronic acid treatment improves bacterial cystitis and reduces cystitis-induced hypercontractility in rats.
International journal of urology : official journal of the Japanese Urological Association, , Volume: 22, Issue:6, 2015

Mesenteric lymph duct drainage attenuates acute lung injury in rats with severe intraperitoneal infection.
Inflammation, , Volume: 38, Issue:3, 2015

Exogenous carbon monoxide suppresses Escherichia coli vitality and improves survival in an Escherichia coli-induced murine sepsis model.
Acta pharmacologica Sinica, , Volume: 35, Issue:12, 2014

Intravenous infusion of mesenteric lymph from severe intraperitoneal infection rats causes lung injury in healthy rats.
World journal of gastroenterology, , Apr-28, Volume: 20, Issue:16, 2014

New markers: urine xanthine oxidase and myeloperoxidase in the early detection of urinary tract infection.
Disease markers, , Volume: 2014, 2014

Evaluation of the effects of ozone therapy on Escherichia coli-induced cytitis in rat.
Irish journal of medical science, , Volume: 182, Issue:4, 2013

Antenatal betamethasone attenuates intrauterine infection-aggravated hyperoxia-induced lung injury in neonatal rats.
Pediatric research, , Volume: 73, Issue:6, 2013

Anti-LAMP-2 antibodies are not prevalent in patients with antineutrophil cytoplasmic autoantibody glomerulonephritis.
Journal of the American Society of Nephrology : JASN, , Volume: 23, Issue:3, 2012

Alcohol impairs the myeloid proliferative response to bacteremia in mice by inhibiting the stem cell antigen-1/ERK pathway.
Journal of immunology (Baltimore, Md. : 1950), , Feb-15, Volume: 188, Issue:4, 2012

Gut flora enhance bacterial clearance in lung through toll-like receptors 4.
Journal of biomedical science, , Sep-10, Volume: 18, 2011

Repeated systemic Escherichia coli infection enhances anti-oxidant response in hypercholesterolemic mice inducing cardiovascular inflammation.
Inflammation, , Volume: 32, Issue:2, 2009

Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice.
American journal of physiology. Lung cellular and molecular physiology, , Volume: 295, Issue:1, 2008

Modulation of host innate immune response in the bladder by uropathogenic Escherichia coli.
Infection and immunity, , Volume: 75, Issue:11, 2007

LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression.
The Journal of trauma, , Volume: 60, Issue:1, 2006

Effect of leukotoxin of Mannheimia haemolytica and LPS of E. coli on secretory response of bovine neutrophils in vitro.
Polish journal of veterinary sciences, , Volume: 8, Issue:2, 2005

Different effects of surfactant and inhaled nitric oxide in modulation of inflammatory injury in ventilated piglet lungs.
Pulmonary pharmacology & therapeutics, , Volume: 18, Issue:4, 2005

Urinary tract infection in iNOS-deficient mice with focus on bacterial sensitivity to nitric oxide.
American journal of physiology. Renal physiology, , Volume: 284, Issue:1, 2003

Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia.
Journal of immunology (Baltimore, Md. : 1950), , Mar-01, Volume: 164, Issue:5, 2000

Platelet-activating factor and bacteremia-induced pulmonary hypertension.
The Journal of surgical research, , Volume: 88, Issue:2, 2000

Concomitant increase in neutrophil adhesion to inflammatory peritoneum and remote organs during peritonitis.
The Journal of surgical research, , Volume: 81, Issue:2, 1999

Partial liquid ventilation reduces pulmonary neutrophil accumulation in an experimental model of systemic endotoxemia and acute lung injury.
Critical care medicine, , Volume: 26, Issue:10, 1998

Influence of antimicrobial agents on bactericidal activity of bovine milk polymorphonuclear leukocytes.
Veterinary immunology and immunopathology, , Volume: 56, Issue:3-4, 1997

KatP, a novel catalase-peroxidase encoded by the large plasmid of enterohaemorrhagic Escherichia coli O157:H7.
Microbiology (Reading, England), , Volume: 142 ( Pt 11), 1996

A novel leukotriene B4-receptor antagonist in endotoxin shock: a prospective, controlled trial in a porcine model.
Critical care medicine, , Volume: 21, Issue:12, 1993

[Measurement of myeloperoxidase and thiobarbituric acid-reactive material in plasma and bronchoalveolar lavage in E. coli-induced acute lung injury].
Nihon Kyobu Shikkan Gakkai zasshi, , Volume: 31, Issue:8, 1993

Granulocyte colony-stimulating factor prevents ethanol-induced impairment in host defense in septic rats.
Alcoholism, clinical and experimental research, , Volume: 17, Issue:6, 1993

Effect of granulocyte colony-stimulating factor on sepsis-induced changes in neutrophil accumulation and organ glucose uptake.
The Journal of infectious diseases, , Volume: 166, Issue:2, 1992

Sepsis- and endotoxin-induced increase in organ glucose uptake in leukocyte-depleted rats.
The American journal of physiology, , Volume: 263, Issue:6 Pt 2, 1992

Induction of Escherichia coli mastitis in cows fed selenium-deficient or selenium-supplemented diets.
American journal of veterinary research, , Volume: 50, Issue:12, 1989

Role of complement-derived and bacterial formylpeptide chemotactic factors in the in vivo migration of neutrophils in experimental Escherichia coli pyelonephritis in rats.
The Journal of infectious diseases, , Volume: 159, Issue:5, 1989

Neutrophil function in a rat model of endotoxin-induced lung injury.
Archives of surgery (Chicago, Ill. : 1960), , Volume: 122, Issue:2, 1987

Intestinal and systemic inflammation induced by symptomatic and asymptomatic enterotoxigenic
Gut microbes, , Volume: 13, Issue:1

The differences in myeloperoxidase activity and consumption of thyroid hormones by bactericidal systems in guinea pigs with peritoneal contamination.
Materia medica Polona. Polish journal of medicine and pharmacy, , Volume: 23, Issue:4

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Some of the effective factors in the pathogenesis of gastro-oesophageal reflux disease.
Journal of cellular and molecular medicine, , Volume: 22, Issue:12, 2018

Tracking significant modules and key genes for esophageal squamous cell carcinoma based on differential modules.
Journal of cancer research and therapeutics, , Volume: 14, Issue:Supplement, 2018

Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma.
Medical science monitor : international medical journal of experimental and clinical research, , Sep-07, Volume: 21, 2015

Evaluation of a 4-protein serum biomarker panel-biglycan, annexin-A6, myeloperoxidase, and protein S100-A9 (B-AMP)-for the detection of esophageal adenocarcinoma.
Cancer, , Dec-15, Volume: 120, Issue:24, 2014

Ultra-small particles of iron oxide as peroxidase for immunohistochemical detection.
Nanotechnology, , Jun-03, Volume: 22, Issue:22, 2011

Association of the polymorphisms of MTHFR C677T, VDR C352T, and MPO G463A with risk for esophageal squamous cell dysplasia and carcinoma.
Archives of medical research, , Volume: 39, Issue:6, 2008

Effect of inflammation on cyclooxygenase (COX)-2 expression in benign and malignant oesophageal cells.
Carcinogenesis, , Volume: 26, Issue:9, 2005

[Production of active oxygen by neutrophils in patients with cancer of the esophagus and stomach before and after surgical interventions].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], , Volume: 50, Issue:4, 2005

Simultaneous progression of oxidative stress and angiogenesis in malignant transformation of Barrett esophagus.
The Journal of thoracic and cardiovascular surgery, , Volume: 126, Issue:6, 2003

Oxidative stress has a role in malignant transformation in Barrett's oesophagus.
International journal of cancer, , Dec-20, Volume: 102, Issue:6, 2002

Possible risk reduction in esophageal cancer associated with MPO -463 A allele.
Journal of epidemiology, , Volume: 11, Issue:3, 2001

Factors related to impaired bactericidal activity in patients with esophageal cancer.
Surgery today, , Volume: 25, Issue:4, 1995

Impaired neutrophil bactericidal activity correlates with the infection occurring after surgery for esophageal cancer.
Journal of surgical oncology, , Volume: 51, Issue:3, 1992

Protective effect of dimethyl sulfoxide on stricture formation in corrosive esophageal burns in rats.
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, , Volume: 24, Issue:5, 2014

Evaluation of systemic oxidative status and mononuclear leukocytes DNA damage in children with caustic esophageal stricture.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, , Volume: 19, Issue:4, 2006

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

A novel murine model of esophageal nonerosive reflux disease: from inflammation to impairment in mucosal integrity.
American journal of physiology. Gastrointestinal and liver physiology, , Jun-01, Volume: 312, Issue:6, 2017

Gender differences in oesophageal mucosal injury in a reflux oesophagitis model of rats.
Gut, , Volume: 62, Issue:1, 2013

Exogenous luminal nitric oxide exacerbates esophagus tissue damage in a reflux esophagitis model of rats.
Scandinavian journal of gastroenterology, , Volume: 44, Issue:5, 2009

Systemic phosphatidylcholine pretreatment protects canine esophageal mucosa during acute experimental biliary reflux.
World journal of gastroenterology, , Jan-14, Volume: 12, Issue:2, 2006

Prevention by rebamipide of acute reflux esophagitis in rats.
Digestive diseases and sciences, , Volume: 50 Suppl 1, 2005

Microcirculatory changes in the canine oesophageal mucosa during experimental reflux oesophagitis: comparison of the effects of acid and bile.
Scandinavian journal of gastroenterology, , Volume: 38, Issue:10, 2003

Effects of rutin and harmaline on rat reflux oesophagitis.
Autonomic & autacoid pharmacology, , Volume: 22, Issue:1, 2002

Esophagitis-related esophageal shortening in opossum is associated with longitudinal muscle hyperresponsiveness.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 280, Issue:3, 2001

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Paediatric-onset generalized pustular psoriasis secondary to myeloperoxidase mutations.
Clinical and experimental dermatology, , 02-02, Volume: 48, Issue:2, 2023

Pantoprazole and perinuclear antineutrophil cytoplasmic antibody-associated vasculitis.
The Journal of rheumatology, , Volume: 33, Issue:3, 2006

Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 30-2002. An eight-year-old girl with fever, hemoptysis, and pulmonary consolidations.
The New England journal of medicine, , Sep-26, Volume: 347, Issue:13, 2002

Orbital myeloid sarcoma presenting as massive proptosis.
Hematology/oncology and stem cell therapy, , Volume: 6, Issue:1, 2013

Sino-orbital chloroma presenting as unilateral proptosis in a boy.
International journal of pediatric otorhinolaryngology, , Volume: 69, Issue:11, 2005

Time-dependent analysis of nociception and anxiety-like behavior in rats submitted to persistent inflammation of the temporomandibular joint.
Physiology & behavior, , Feb-10, Volume: 125, 2014

Infrared (810-nm) low-level laser therapy on rat experimental knee inflammation.
Lasers in medical science, , Volume: 27, Issue:1, 2012

Neuroprotective efficacy and therapeutic window of Forsythoside B: in a rat model of cerebral ischemia and reperfusion injury.
European journal of pharmacology, , Aug-25, Volume: 640, Issue:1-3, 2010

Participation of peripheral tachykinin NK1 receptors in the carrageenan-induced inflammation of the rat temporomandibular joint.
European journal of pain (London, England), , Volume: 13, Issue:8, 2009

Suppression of endotoxin-induced inflammation by taxol.
The European respiratory journal, , Volume: 30, Issue:3, 2007

Matrix metalloproteinase-9 and myeloperoxidase expression: quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemia.
Stroke, , Volume: 35, Issue:5, 2004

Effect of MEN 11467, a new tachykinin NK1 receptor antagonist, in acute rectocolitis induced by acetic acid in guinea-pigs.
European journal of pharmacology, , Jun-18, Volume: 374, Issue:2, 1999

The association between ear involvement and clinical features and prognosis in ANCA-associated vasculitis.
Auris, nasus, larynx, , Volume: 48, Issue:5, 2021

The complexity of classifying ANCA-associated small-vessel vasculitis in actual clinical practice: data from a multicenter retrospective survey.
Rheumatology international, , Volume: 40, Issue:2, 2020

Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody-associated vasculitis.
Rheumatology (Oxford, England), , 11-01, Volume: 56, Issue:11, 2017

Myeloperoxidase-Antineutrophil Cytoplasmic Antibody (ANCA)-Positive and ANCA-Negative Patients With Granulomatosis With Polyangiitis (Wegener's): Distinct Patient Subsets.
Arthritis & rheumatology (Hoboken, N.J.), , Volume: 68, Issue:12, 2016

Myeloperoxidase-Antineutrophil Cytoplasmic Antibody (ANCA)-Positive Granulomatosis With Polyangiitis (Wegener's) Is a Clinically Distinct Subset of ANCA-Associated Vasculitis: A Retrospective Analysis of 315 Patients From a German Vasculitis Referral Cent
Arthritis & rheumatology (Hoboken, N.J.), , Volume: 68, Issue:12, 2016

Characteristics of Chinese patients with Wegener's granulomatosis with anti-myeloperoxidase autoantibodies.
Kidney international, , Volume: 68, Issue:5, 2005

Increased lipid peroxide levels and myeloperoxidase activity in the vitreous of patients suffering from proliferative diabetic retinopathy.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, , Volume: 231, Issue:11, 1993

Eye manifestations in patients with perinuclear antineutrophil cytoplasmic antibody-associated vasculitis: case series and literature review.
Japanese journal of ophthalmology, , Volume: 51, Issue:2

Low-Level Blast Exposure Increases Transient Receptor Potential Vanilloid 1 (TRPV1) Expression in the Rat Cornea.
Current eye research, , Volume: 41, Issue:10, 2016

Lipoxin A₄ inhibits platelet-activating factor inflammatory response and stimulates corneal wound healing of injuries that compromise the stroma.
Experimental eye research, , Volume: 103, 2012

Selective activation of the prostaglandin E2 circuit in chronic injury-induced pathologic angiogenesis.
Investigative ophthalmology & visual science, , Volume: 51, Issue:12, 2010

Topical methimazole as a new treatment for postinflammatory hyperpigmentation: report of the first case.
Dermatology (Basel, Switzerland), , Volume: 211, Issue:4, 2005

[ANCA-positive lupus erythematodes profundus. Successful therapy with low dosage dapsone].
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A Retrospective Case-Control Study of the Relationship between the Gut Microbiota, Enteropathy, and Child Growth.
The American journal of tropical medicine and hygiene, , Volume: 103, Issue:1, 2020

A Longitudinal Study of Household Water, Sanitation, and Hygiene Characteristics and Environmental Enteropathy Markers in Children Less than 24 Months in Iquitos, Peru.
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A methodologic framework for modeling and assessing biomarkers of environmental enteropathy as predictors of growth in infants: an example from a Peruvian birth cohort.
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Fecal Markers of Environmental Enteropathy and Subsequent Growth in Bangladeshi Children.
The American journal of tropical medicine and hygiene, , Sep-07, Volume: 95, Issue:3, 2016

Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants.
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Long-term clinical significance of thyroid autoimmunity in children with celiac disease.
The Journal of pediatrics, , Volume: 156, Issue:2, 2010

Mice with combined disruption of Gpx1 and Gpx2 genes have colitis.
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Acute myeloid leukemia mimicking primary testicular neoplasm. Presentation of a case with review of literature.
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Copper oxide and closantel prevent alterations in hepatic energetic metabolism and reduce inflammation in Haemonchus contortus infection.
Experimental parasitology, , Volume: 204, 2019

Leucocyte-derived extracellular trap formation significantly contributes to Haemonchus contortus larval entrapment.
Parasites & vectors, , Nov-26, Volume: 8, 2015

Peroxide-supported in-vitro cytochrome P450 activities in Haemonchus contortus.
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Platelet-activating factor receptor-deficient mice show an unaltered clearance of nontypeable Haemophilus influenzae from their respiratory tract.
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Pompholyx-like manifestation in Churg-Strauss syndrome.
European journal of dermatology : EJD, , Volume: 25, Issue:2, 2015

Neutrophil granulocyte function in pustulosis palmoplantaris.
Acta dermato-venereologica, , Volume: 58, Issue:6, 1978

Clinical Efficacy of Andrographolide Sulfonate in the Treatment of Severe Hand, Foot, and Mouth Disease (HFMD) is Dependent upon Inhibition of Neutrophil Activation.
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Radiobiological comparison of flattening filter (FF) and flattening filter-free (FFF) beam in rat laryngeal tissue.
International journal of radiation biology, , Volume: 97, Issue:2, 2021

The association between immunoexpression levels of oxidant and antioxidant enzymes and lip squamous cell carcinoma.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, , Volume: 126, Issue:5, 2018

ROS related enzyme levels and its association to molecular signaling pathway in the development of head and neck cancer.
Cellular and molecular biology (Noisy-le-Grand, France), , May-30, Volume: 64, Issue:7, 2018

The relationship between the severity of radiation-induced oral mucositis and the myeloperoxidase levels in rats.
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A novel model of megavoltage radiation-induced oral mucositis in hamsters: Role of inflammatory cytokines and nitric oxide.
International journal of radiation biology, , Volume: 91, Issue:6, 2015

Myeloid sarcoma of the head and neck region.
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Development of primary hypothyroidism with antithyroglobulin, antiperoxidase, and blocking-type thyrotropin receptor antibodies after radiation therapy for neuroblastoma.
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Parotid saliva composition during and after irradiation of head and neck cancer.
European journal of cancer. Part B, Oral oncology, , Volume: 30B, Issue:4, 1994

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Hypertrophic Pachymeningitis Associated with Myeloperoxidase-anti-neutrophil Cytoplasmic Antibodies Induced by Propylthiouracil.
Internal medicine (Tokyo, Japan), , Jul-01, Volume: 62, Issue:13, 2023

Hypertrophic pachymeningitis and cerebral venous thrombosis in myeloperoxidase-ANCA associated vasculitis.
BMJ case reports, , Jan-10, Volume: 12, Issue:1, 2019

Case 32-2017. A 64-Year-Old Man with Dyspnea, Wheezing, Headache, Cough, and Night Sweats.
The New England journal of medicine, , 10-19, Volume: 377, Issue:16, 2017

[IgG4- and MPO-ANCA-associated hypertrophic pachymeningitis].
Revista de neurologia, , Nov-16, Volume: 61, Issue:10, 2015

Hypertrophic pachymeningitis with MPO-ANCA-positive vasculitis.
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Pathologica, , Volume: 97, Issue:5, 2005

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[Granulocytic sarcoma of the brain revealed on vascular mode].
Revue neurologique, , Volume: 164, Issue:6-7

Frequency of audiological complaints in patients with fibromyalgia syndrome and its relationship with oxidative stress.
Nigerian journal of clinical practice, , Volume: 21, Issue:10, 2018

A case of MPO-ANCA-positive polyarteritis nodosa complicated by exudative otitis media, mononeuritis multiplex, and acute renal failure.
Clinical and experimental nephrology, , Volume: 15, Issue:5, 2011

Clinical features of bilateral progressive hearing loss associated with myeloperoxidase-antineutrophil cytoplasmic antibody.
The Annals of otology, rhinology, and laryngology, , Volume: 113, Issue:5, 2004

Progressive bilateral sensorineural hearing loss induced by an antithyroid drug.
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[A case of microscopic polyangitis accompanied by hearing loss as the initial sign of the disease].
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Is there a relationship between myeloperoxidase activity and conductive hearing loss in chronic otitis media complicated by cholesteatoma?
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[Inner ear 3D-FLAIR magnetic resonance image evaluation of MPO-ANCA related angitis patients].
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Otolaryngologic manifestations of antineutrophil cytoplasmic antibody-associated vasculitis.
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A patient with myeloperoxidase antineutrophil cytoplasmic antibody-positive polyangiitis who developed sensorineural hearing loss and scleritis.
Internal medicine (Tokyo, Japan), , Volume: 50, Issue:16, 2011

The occurrence of sensorineural hearing loss in a patient with myeloperoxidase-anti-neutrophil cytoplasmic antibody-related microscopic polyangiitis.
Rheumatology international, , Volume: 27, Issue:5, 2007

Progressive bilateral sensorineural hearing loss induced by an antithyroid drug.
ORL; journal for oto-rhino-laryngology and its related specialties, , Volume: 66, Issue:5, 2004

[Neurosensory deafness: immunological aspects].
Problemy tuberkuleza i boleznei legkikh, , Issue:8, 2003

Myeloperoxidase-antineutrophil cytoplasmic antibody-associated sensorineural hearing loss.
Auris, nasus, larynx, , Volume: 28 Suppl, 2001

Expression of myeloperoxidase and cochlear dysfunction in the lipopolysaccharide-treated guinea pig.
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Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 28-1998. A 64-year-old man with cranial-nerve palsies and a positive test for antinuclear cytoplasmic antibodies.
The New England journal of medicine, , Sep-10, Volume: 339, Issue:11, 1998

[A case of myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA)-related glomerulonephritis associated with Cogan's syndrome].
Nihon Jinzo Gakkai shi, , Volume: 38, Issue:9, 1996

The relationship between thiol-disulfide balance and idiopathic sudden sensorineural hearing loss.
Brazilian journal of otorhinolaryngology, , Volume: 88, Issue:6

PREDICTIVE VALUE OF NEUTROPHIL EXTRACELLULAR TRAP COMPONENTS FOR 28-DAY ALL-CAUSE MORTALITY IN PATIENTS WITH CARDIAC ARREST: A PILOT OBSERVATIONAL STUDY.
Shock (Augusta, Ga.), , Nov-01, Volume: 60, Issue:5, 2023

Improved Survival and Neurological Outcomes after Cardiopulmonary Resuscitation in Toll-like Receptor 4-mutant Mice.
Chinese medical journal, , Oct-05, Volume: 128, Issue:19, 2015

Hypothermia and anesthetic postconditioning influence the expression and activity of small intestinal proteins possibly involved in ischemia/reperfusion-mediated events following cardiopulmonary resuscitation.
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Pyruvate enhances neurological recovery following cardiopulmonary arrest and resuscitation.
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Poly(ADP-ribose) polymerase inhibitor PJ-34 reduces mesenteric vascular injury induced by experimental cardiopulmonary bypass with cardiac arrest.
American journal of physiology. Heart and circulatory physiology, , Volume: 288, Issue:6, 2005

Controlled intermittent asystole cardiac therapy induced by pharmacologically potentiated vagus nerve stimulation in normal and hibernating myocardium.
The Annals of thoracic surgery, , Volume: 75, Issue:6, 2003

Mild hypothermia induced before cardiac arrest reduces brain edema formation in rats.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, , Volume: 9, Issue:2, 2002

Short-term inhaled nitric oxide in canine lung transplantation from non-heart-beating donor.
The Annals of thoracic surgery, , Volume: 70, Issue:5, 2000

Hypothyroidism and antithyroglobulin and antithyroperoxidase antibodies in the pathogenesis of autoimmune associated congenital heart block.
The Journal of rheumatology, , Volume: 33, Issue:10, 2006

[A case of MPO-ANCA positive vasculitis associated with diffuse alveolar hemorrhage and various cardiac conducting system abnormalities following propylthiouracil treatment].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, , Volume: 42, Issue:4, 2004

Influence of the type of congenital heart defects on epithelial lining fluid composition in infants undergoing cardiac surgery with cardiopulmonary bypass.
Pediatric research, , Volume: 83, Issue:4, 2018

CXC-chemokine stimulation of neutrophils correlates with plasma levels of myeloperoxidase and lactoferrin and contributes to clinical outcome after pediatric cardiac surgery.
Shock (Augusta, Ga.), , Volume: 22, Issue:6, 2004

Heparin-coated cardiopulmonary bypass circuits reduce circulating complement factors and interleukin-6 in paediatric heart surgery.
Scandinavian cardiovascular journal : SCJ, , Volume: 34, Issue:1, 2000

Rationale and design of ENDEAVOR: A sequential phase 2b-3 randomized clinical trial to evaluate the effect of myeloperoxidase inhibition on symptoms and exercise capacity in heart failure with preserved or mildly reduced ejection fraction.
European journal of heart failure, , Volume: 25, Issue:9, 2023

Changes in Cardiovascular Biomarkers With Breast Cancer Therapy and Associations With Cardiac Dysfunction.
Journal of the American Heart Association, , 01-21, Volume: 9, Issue:2, 2020

Cardioprotective Effects of Atorvastatin Are Mediated Through PPARγ in Paraquat-Exposed Rats.
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Utility of myeloperoxidase in the differential diagnosis of acute coronary syndrome.
Archivos de cardiologia de Mexico, , Volume: 88, Issue:5, 2018

Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody-associated vasculitis.
Rheumatology (Oxford, England), , 11-01, Volume: 56, Issue:11, 2017

Antioxidant and antiapoptotic effects of sea cucumber and valsartan against doxorubicin-induced cardiotoxicity in rats: The role of low dose gamma irradiation.
Journal of photochemistry and photobiology. B, Biology, , Volume: 170, 2017

Inflammation and the Heart: A Commentary.
Alternative therapies in health and medicine, , Volume: 22, Issue:5, 2016

Utilizing cardiac biomarkers to detect and prevent chemotherapy-induced cardiomyopathy.
Current heart failure reports, , Volume: 12, Issue:3, 2015

Endogenous Estrogen-Mediated Heme Oxygenase Regulation in Experimental Menopause.
Oxidative medicine and cellular longevity, , Volume: 2015, 2015

Growth differentiation factor-15 (GDF-15) levels are associated with cardiac and renal injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass.
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Connection between cardiac vascular permeability, myocardial edema, and inflammation during sepsis: role of the α1AMP-activated protein kinase isoform.
Critical care medicine, , Volume: 41, Issue:12, 2013

Inhibition of vascular peroxidase alleviates cardiac dysfunction and apoptosis induced by ischemia-reperfusion.
Canadian journal of physiology and pharmacology, , Volume: 90, Issue:7, 2012

Cardioprotective effect of resveratrol on lipopolysaccharide-induced oxidative stress in rat.
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Clinica chimica acta; international journal of clinical chemistry, , Nov-11, Volume: 411, Issue:21-22, 2010

Cardiac: is this biomarker ready for the prime time?
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Apoptosis in cardiac myocytes during the early stage after severe burn.
The Journal of trauma, , Volume: 65, Issue:2, 2008

p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage.
American journal of physiology. Heart and circulatory physiology, , Volume: 294, Issue:6, 2008

Oligomers of resveratrol and ferulic acid prepared by peroxidase-catalyzed oxidation and their protective effects on cardiac injury.
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Biomarkers provide clues to earlier diagnoses. Tiny molecules in the bloodstream may help doctors identify heart disease sooner, which could lead to more timely treatments.
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New tests for heart disease.
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Erdosteine prevents doxorubicin-induced cardiotoxicity in rats.
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Inhibition of adhesion molecules markedly ameliorates cytokine-induced sustained myocardial dysfunction in dogs in vivo.
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Protective effects of caffeic acid phenethyl ester on doxorubicin-induced cardiotoxicity in rats.
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Effects of caffeic acid phenethyl ester on endotoxin-induced cardiac stress in rats: a possible mechanism of protection.
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Histone deacetylase inhibitor, mocetinostat, regulates cardiac remodelling and renin-angiotensin system activity in rats with transverse aortic constriction-induced pressure overload cardiac hypertrophy.
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Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy.
Proceedings of the National Academy of Sciences of the United States of America, , Jun-11, Volume: 110, Issue:24, 2013

Protective effects and active ingredients of yi-qi-fu-mai sterile powder against myocardial oxidative damage in mice.
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Reduced silent information regulator 1 signaling exacerbates sepsis-induced myocardial injury and mitigates the protective effect of a liver X receptor agonist.
Free radical biology & medicine, , Volume: 113, 2017

Pentraxin 3, ischemia-modified albumin, and myeloperoxidase in predicting a cardiac damage in acute carbon monoxide poisoning.
The American journal of emergency medicine, , Volume: 34, Issue:10, 2016

Tropisetron attenuates cardiac injury in a rat trauma-hemorrhage model.
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Myeloperoxidase increased cardiomyocyte protein nitration in mice subjected to nonlethal mechanical trauma.
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Protection from cardiac injury by induction of heme oxygenase-1 and nitric oxide synthase in a focal ischaemia-reperfusion model.
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Myeloid sarcoma of the heart.
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MPO-ANCA-associated pseudovasculitis in cardiac myxoma.
European journal of neurology, , Volume: 12, Issue:8, 2005

Ac-SDKP decreases mortality and cardiac rupture after acute myocardial infarction.
PloS one, , Volume: 13, Issue:1, 2018

Olmesartan prevents cardiac rupture in mice with myocardial infarction by modulating growth differentiation factor 15 and p53.
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Critical role for white blood cell NAD(P)H oxidase-mediated plasminogen activator inhibitor-1 oxidation and ventricular rupture following acute myocardial infarction.
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Critical role for white blood cell NAD(P)H oxidase-mediated plasminogen activator inhibitor-1 oxidation and ventricular rupture following acute myocardial infarction.
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On the trail of genes for recovery. Homing in on why heart healing is slow for some, fast for others.
Heart advisor, , Volume: 6, Issue:3, 2003

Leukocyte depletion in a neonatal model of cardiac surgery.
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Influence of the type of congenital heart defects on epithelial lining fluid composition in infants undergoing cardiac surgery with cardiopulmonary bypass.
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Rapid aortic and mitral valve thickening and regurgitation with complete atrioventricular block due to myeloperoxidase anti-neutrophil cytoplasmic antibody-associated vasculitis.
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Interactions between inflammatory activation and endothelial dysfunction selectively modulate valve disease progression in patients with bicuspid aortic valve.
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Regular exercise training prevents aortic valve disease in low-density lipoprotein-receptor-deficient mice.
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Histoenzymological and ultrastructural investigations regarding the role of the endogenous peroxidase at the pulmonary level in cardiogenic pulmonary hypertension.
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Uptake of recombinant myeloperoxidase, free or fused to Fc gamma, by macrophages enhances killing activity toward micro-organisms.
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Isolated diffuse hemangiomatosis of the spleen with Kasabach-Merritt-like syndrome.
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Influence of acetylsalicylic acid on hematotoxicity of benzene.
International journal of occupational medicine and environmental health, , Volume: 26, Issue:5, 2013

GSTT1 null and MPO -463G>a polymorphisms and carboplatin toxicity in an Indian population.
Asian Pacific journal of cancer prevention : APJCP, , Volume: 14, Issue:8, 2013

Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity.
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An ultrastructural study of primary granule subtypes in human neutrophils.
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Parallel tubular granules in human immature neutrophils--an electron microscopic study.
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[Coexistence of 2 distinct populations of neutrophil granulocytes, one totally, the other partially deficient in myeloperoxidase].
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Correlation of messenger RNA levels with protein defects in specific granule deficiency.
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Myeloperoxidase: a specific marker for myeloid cells in paraffin sections.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, , Volume: 4, Issue:6, 1991

Hydroxylation of phenol to hydroquinone catalyzed by a human myeloperoxidase-superoxide complex: possible implications in benzene-induced myelotoxicity.
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Effects of recombinant granulocyte colony-stimulating factor treatment on hematopoietic cycles and cellular defects associated with canine cyclic hematopoiesis.
Experimental hematology, , Volume: 18, Issue:11, 1990

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Selective defect in myeloid cell lactoferrin gene expression in neutrophil specific granule deficiency.
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Plasma myeloperoxidase and lactoferrin measured by radioimmunoassay: relations to neutrophil kinetics.
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Klinische Wochenschrift, , Jul-15, Volume: 53, Issue:14, 1975

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Human natural tumor necrosis factor alpha induces multiple endocrine and hematologic disorders in rats.
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Urinary isomorphic red blood cells for the prediction of disease severity and renal outcomes in MPO-ANCA-associated vasculitis: a retrospective cohort study.
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Pitfalls in the diagnosis of hematuria.
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Characterization of a Rat Model of Myeloperoxidase-Anti-Neutrophil Cytoplasmic Antibody-Associated Crescentic Glomerulonephritis.
Nephron, , Volume: 145, Issue:4, 2021

Sphingosine-1-phosphate receptor modulator FTY720 attenuates experimental myeloperoxidase-ANCA vasculitis in a T cell-dependent manner.
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ANCA-associated vasculitis in scleroderma: A renal perspective .
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Clinical and pathologic characteristics of pauci-immune anti-myeloperoxidase antibody associated glomerulonephritis with nephrotic range proteinuria.
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Antinuclear Antibody-Negative Lupus Nephritis with Full House Nephropathy: A Case Report and Review of the Literature.
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PloS one, , Volume: 10, Issue:4, 2015

C5a receptor (CD88) blockade protects against MPO-ANCA GN.
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Myeloperoxidase-antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis with rheumatoid arthritis: a comparison of patients without rheumatoid arthritis.
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Evaluation of the ameliorative effects of immunosuppressants on crescentic glomerulonephritis in SCG/Kj mice.
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MPO-ANCA-positive IgA nephropathy successfully treated with tonsillectomy.
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Unusual malignant cells in urine.
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Underwater high frequency noise: Biological responses in sea urchin Arbacia lixula (Linnaeus, 1758).
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Oxidative medicine and cellular longevity, , Volume: 2019, 2019

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Modulation of immune response and protective efficacy of recombinant outer-membrane protein F (rOmpF) of Aeromonas hydrophila in Labeo rohita.
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Binding of human myeloperoxidase to red blood cells: Molecular targets and biophysical consequences at the plasma membrane level.
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Suicidal inactivation of methemoglobin by generation of thiyl radical: insight into NAC mediated protection in RBC.
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Bupleurum chinense DC polysaccharides attenuates lipopolysaccharide-induced acute lung injury in mice.
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In vitro evaluation of PHISIO-coated sets for pediatric cardiac surgery.
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Hypersusceptibility of neutrophil granulocytes towards lethal action of free fatty acids contained in enzyme-modified atherogenic low density lipoprotein.
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Systemic complement depletion diminishes perihematomal brain edema in rats.
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Complement depletion improves neurological function in cerebral ischemia.
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Neuromelanogenic and cytotoxic properties of canine brainstem peroxidase.
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Total and unbound bilirubin determination using an automated peroxidase micromethod.
The Kobe journal of medical sciences, , Volume: 28, Issue:2, 1982

An oxygen-dependent mechanism of neutrophil-mediated cytotoxicity.
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A comparison of the lytic properties of two ether-linked lipids, one with and one without antineoplastic activity.
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A Ruptured Jejunal Arterial Aneurysm in a Young Woman Undergoing Chronic Hemodialysis Due to Myeloperoxidase-antineutrophil Cytoplasmic Antibody-associated Vasculitis.
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MAGL inhibition modulates gastric secretion and motility following NSAID exposure in mice.
European journal of pharmacology, , Jul-15, Volume: 807, 2017

Prophylactic effect of egualen sodium, a stable azulene derivative, on gastrointestinal damage induced by ischemia/reperfusion, double antiplatelet therapy and loxoprofen in rats.
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A new model of gastric bleeding induced in rats by aspirin plus clopidogrel under stimulation of acid secretion. Prophylactic effects of antiulcer drugs.
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Analysing the role of COX-2 in acute oesophagitis and in melatonin-exerted protection against experimental reflux oesophagitis in rats.
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The structural basis for the prevention of nonsteroidal antiinflammatory drug-induced gastrointestinal tract damage by the C-lobe of bovine colostrum lactoferrin.
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Partially hydrolyzed guar gum attenuates the severity of pouchitis in a rat model of ileal J pouch-anal anastomosis.
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Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis.
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In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027.
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The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damage.
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Mechanisms of the anti-inflammatory effects of the natural secosteroids physalins in a model of intestinal ischaemia and reperfusion injury.
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Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs: importance of gastric hypermotility.
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The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitis.
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Bloody diarrhea, fever, and pancytopenia in a patient with active ulcerative colitis.
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Acute myeloid leukemia presenting as non-neutropenic colitis in an infant.
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Effects of meloxicam on oxygen radical generation in rat gastric mucosa.
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[A case of MPO-ANCA-related vasculitis that recurred as gastrointestinal bleeding and presented difficulty in treatment].
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New ulcerative colitis model induced by sulfhydryl blockers in rats and the effects of antiinflammatory drugs on the colitis.
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Diethyldithiocarbamate, a superoxide dismutase inhibitor, reduces indomethacin-induced gastric lesions in rats.
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Adaptation of rat gastric mucosa to aspirin requires mucosal contact.
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Verotoxin induces hemorrhagic lesions in rat small intestine. Temporal alteration of vasoactive substances.
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Effect of sialoadenectomy on ethanol-induced gastric mucosal damage in the rat: role of neutrophils.
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Role of CXCR2 and TRPV1 in functional, inflammatory and behavioural changes in the rat model of cyclophosphamide-induced haemorrhagic cystitis.
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A retrospective controlled study of thiol disulfide homeostasis as a novel marker in Crimean Congo hemorrhagic fever.
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The importance of myeloperoxidase enzyme activity in the pathogenesis of Crimean-Congo haemorrhagic fever.
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Elevation of Myeloperoxidase Correlates with Disease Severity in Patients with Hantaan Virus Infection.
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Neutrophil Activation in Acute Hemorrhagic Fever With Renal Syndrome Is Mediated by Hantavirus-Infected Microvascular Endothelial Cells.
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Therapeutic sesamol attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats by inhibiting matrix metalloproteinase-9.
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Dai-kenchu-to attenuates rat sinusoidal obstruction syndrome by inhibiting the accumulation of neutrophils in the liver.
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[Functional and metabolic activity of peripheral blood neutrophils in acute viral hepatitis B and C].
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Rise of plasma myeloperoxidase during interferon therapy.
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Biphasic control of polymorphonuclear cell migration by Kupffer cells. Effect of exposure to metabolic products of ethanol.
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Mice lacking inducible nitric oxide synthase show strong resistance to anti-Fas antibody-induced fulminant hepatitis.
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Hepatic inflammation following 70% hepatectomy may be related to up-regulation of epithelial neutrophil activating protein-78.
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Detecting the replication of the hepatitis B virus using the ImmunoMax technique following treatment with interferon-alpha in children with chronic hepatitis.
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[Indices of natural body resistance in viral hepatitis].
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Rise of plasma myeloperoxidase during interferon therapy.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
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Myeloperoxidase in human peripheral blood lymphocytes: Production and subcellular localization.
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[Case of MPO-ANCA-positive Wegener's granulomatosis with hepatitis C virus infection].
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Prolonged infections associated with antineutrophil cytoplasmic antibodies specific to proteinase 3 and myeloperoxidase: diagnostic and therapeutic challenge.
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Detection and quantitation of hepatitis C virus RNA in serum using the polymerase chain reaction and a colorimetric enzymatic detection system.
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Reduced post-operative neutrophil activation in liver transplant recipients suffering from post-hepatitic cirrhosis.
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[Functional and metabolic activity of peripheral blood neutrophils in acute viral hepatitis B and C].
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Rise of plasma myeloperoxidase during interferon therapy.
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D-Penicillamine-induced ANCA-associated crescentic glomerulonephritis in Wilson disease.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
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Myeloperoxidase-Sensitive
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Neutrophil extracellular traps in patients with liver cirrhosis and hepatocellular carcinoma.
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Co-Administration of iRGD with Sorafenib-Loaded Iron-Based Metal-Organic Framework as a Targeted Ferroptosis Agent for Liver Cancer Therapy.
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N-acetylcysteine alleviates liver injury by suppressing macrophage-mediated inflammatory response post microwave ablation.
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Nanozyme-assisted sensitive profiling of exosomal proteins for rapid cancer diagnosis.
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Biomineralization Synthesis of the Cobalt Nanozyme in SP94-Ferritin Nanocages for Prognostic Diagnosis of Hepatocellular Carcinoma.
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A variant in myeloperoxidase promoter hastens the emergence of hepatocellular carcinoma in patients with HCV-related cirrhosis.
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Plasma myeloperoxidase levels correlate with hepatocellular carcinoma in chronic hepatitis C.
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Do genetic variations in antioxidant enzymes influence the course of hereditary hemochromatosis?
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Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis.
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Enhanced anti-tumor effects of herpes simplex virus thymidine kinase/ganciclovir system by codelivering monocyte chemoattractant protein-1 in hepatocellular carcinoma.
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DA-125, a novel anthracycline derivative showing high-affinity DNA binding and topoisomerase II inhibitory activities, exerts cytotoxicity via c-Jun N-terminal kinase pathway.
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Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.
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Decreased production of active oxygen species by neutrophils in patients with liver cirrhosis and hepatocellular carcinoma.
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Intracerebellar granulocytic sarcoma. A case report.
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Myeloperoxidase activity as a lung injury marker in the lamb model of congenital diaphragmatic hernia.
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Evaluation of the effect of diacetyl morphine on salivary factors and their changes after methadone therapy.
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Herpes simplex virus type 1 infection of the rat enteric nervous system evokes small-bowel neuromuscular abnormalities.
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Characterization of myeloid-specific peroxidase, keratin 8, and dual specificity phosphatase 1 as innate immune genes involved in the resistance of crucian carp (Carassius auratus gibelio) to Cyprinid herpesvirus 2 infection.
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Eosinophilia in duck embryos induced by an apathogenic strain of duck enteritis virus.
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A case of cerebral aquaporinopathy.
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Unsuspected Langerhans cell histiocytosis can be easily missed in a colonic biopsy.
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Peroxidatic activity distinct from myeloperoxidase in human monocytes cultured in vitro and in alveolar macrophages.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
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Histone deacetylase inhibitors and Hodgkin's lymphoma.
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Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial.
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Clinical development of panobinostat in classical Hodgkin's lymphoma.
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The class-I HDAC inhibitor MGCD0103 induces apoptosis in Hodgkin lymphoma cell lines and synergizes with proteasome inhibitors by an HDAC6-independent mechanism.
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Polymorphisms of drug metabolizing enzymes and markers of genotoxicity to identify patients with Hodgkin's lymphoma at risk of treatment-related complications.
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The activity of neutrophil myeloperoxidase in patients with Hodgkin's disease.
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In-vitro sensitivity of Hodgkin's disease to hydrogen peroxide toxicity. Correlation with peroxidase activity.
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Arginine-rich cationic proteins of human eosinophil granules: comparison of the constituents of eosinophilic and neutrophilic leukocytes.
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Plasma myeloperoxidase and lactoferrin measured by radioimmunoassay: relations to neutrophil kinetics.
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[Research on leukocytic peroxidase in children exposed to roentgen therapy].
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Phase I imaging study of Hodgkin's disease and non-Hodgkin's lymphomas with radiolabeled antibody to eosinophil peroxidase.
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Demonstration by the Nadi reaction of cytochrome oxidase activity in cells of the lymphoid and myeloid series, obtained from normal individuals and patients with Hodgkin's disease.
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[Sensitivity of methods of titration of the vaccine strain of porcine fever virus].
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Rutin and Selenium Co-administration Reverse 3-Nitropropionic Acid-Induced Neurochemical and Molecular Impairments in a Mouse Model of Huntington's Disease.
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Process, Outcomes and Possible Elimination of Aggregation with Special Reference to Heme Proteins; Likely Remediations of Proteinopathies.
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Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice.
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Antimyeloperoxidase antibodies rapidly induce alpha-4-integrin-dependent glomerular neutrophil adhesion.
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[Ki-1 lymphoma of the skin in a patient with Crohn's disease undergoing treatment with azathioprine].
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Helminth infection enhances disease in a murine TH2 model of colitis.
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Tapeworm infection reduces epithelial ion transport abnormalities in murine dextran sulfate sodium-induced colitis.
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Increased RANKL and IL-6 levels might result in high bone turnover in a case of a CD34+/CD117+/myeloperoxidase(+dim) acute myeloid leukemia presenting with severe hypercalcemia and lumbar spine fractures.
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[Idiopathic pulmonary fibrosis and familial benign hypercalcemia syndrome without deficiency in leukocyte myeloperoxidase. A case].
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The inherited association of interstitial lung disease, hypocalciuric hypercalcemia, and defective granulocyte function.
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[Interstitial pneumopathy, hypocalciuric hypercalcemia and defective granulocyte function: a new case].
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The beneficial effects of acute hypercapnia on microcirculatory oxygenation in an animal model of sepsis are independent of K(+)ATP channels.
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Enhancement effects of hypercapnia on the acute lung injury caused by acid aspiration.
The Chinese journal of physiology, , Jun-30, Volume: 52, Issue:3, 2009

Hypercapnic acidosis minimizes endotoxin-induced gut mucosal injury in rabbits.
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Therapeutic effects of hypercapnia on chronic lung injury and vascular remodeling in neonatal rats.
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Endogenous adenosine and secondary injury after chest trauma.
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[Functional activity of peripheral blood neutrophils of rats during combined effects of hypoxia, hypercapnia and cooling].
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Reactive Dicarbonyl Scavenging Effectively Reduces MPO-Mediated Oxidation of HDL and Restores PON1 Activity.
Nutrients, , Jun-30, Volume: 12, Issue:7, 2020

Cinnamaldehyde exerts vasculoprotective effects in hypercholestrolemic rabbits.
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PPAR-γ activator induces neuroprotection in hypercholesterolemic rats subjected to global cerebral ischemia/reperfusion injury: in vivo and in vitro inhibition of oxidative stress.
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Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques.
Circulation, , Aug-18, Volume: 120, Issue:7, 2009

Myeloperoxidase overexpression in children with hypercholesterolemia.
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Myeloperoxidase expression in early life. On the causal pathways for atherosclerosis?
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Repeated systemic Escherichia coli infection enhances anti-oxidant response in hypercholesterolemic mice inducing cardiovascular inflammation.
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Rosiglitazone inhibits hypercholesterolaemia-induced myeloperoxidase upregulation--a novel mechanism for the cardioprotective effects of PPAR agonists.
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Effects of dietary fish oil supplementation on cellular adhesion molecule expression and tissue myeloperoxidase activity in hypercholesterolemic mice with sepsis.
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Effect of hypercholesterolemia on myocardial necrosis and apoptosis in the setting of ischemia-reperfusion.
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Oxidative stress in hypercholesterolemic LDL (low-density lipoprotein) receptor knockout mice is associated with low content of mitochondrial NADP-linked substrates and is partially reversed by citrate replacement.
Free radical biology & medicine, , Feb-01, Volume: 44, Issue:3, 2008

Apolipoprotein E-/- mice have delayed skeletal muscle healing after hind limb ischemia-reperfusion.
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Effects of two whole blood systems (DALI and Liposorber D) for LDL apheresis on lipids and cardiovascular risk markers in severe hypercholesterolemia.
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Effects of D-4F on vasodilation and vessel wall thickness in hypercholesterolemic LDL receptor-null and LDL receptor/apolipoprotein A-I double-knockout mice on Western diet.
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Expression of human myeloperoxidase by macrophages promotes atherosclerosis in mice.
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[Taurine is a possible anti-atherosclerotic agent].
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Influence of hypercholesterolemia and hypertension on ischemia-reperfusion induced P-selectin expression.
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Impact of hypercholesterolemia on toxicity of N-nitrosodiethylamine: biochemical and histopathological effects.
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Reactive Dicarbonyl Scavenging Effectively Reduces MPO-Mediated Oxidation of HDL and Restores PON1 Activity.
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Myeloperoxidase modulation by LDL apheresis in familial hypercholesterolemia.
Lipids in health and disease, , Oct-20, Volume: 10, 2011

Myeloperoxidase levels are not associated with carotid atherosclerosis progression in patients with familial hypercholesterolemia.
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Protective effects of GV1001 on myocardial ischemia‑reperfusion injury.
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Postprandial endothelial function, inflammation, and oxidative stress in obese children and adolescents.
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Effects of the tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters.
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Mast cells may not play a crucial role in the pathogenesis of experimental closed duodenal loop-induced pancreatitis in rats.
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Pregabalin (CI-1008) inhibits the trinitrobenzene sulfonic acid-induced chronic colonic allodynia in the rat.
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TxA2 inhibition and ischemia-induced loss of myocardial function and reactive hyperemia.
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Inflammation-induced intestinal hyperemia in the rat: role of neutrophils.
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A case of MPO- and PR3-ANCA-positive hypertrophic cranial pachymeningitis with elevated serum IgG4.
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Mechanism of peroxidasin inactivation in hyperglycemia: Heme damage by reactive oxygen species.
Biochemical and biophysical research communications, , Dec-31, Volume: 689, 2023

Raffia palm (Raphia hookeri) wine extenuates redox imbalance and modulates activities of glycolytic and cholinergic enzymes in hyperglycemia-induced testicular injury in type 2 diabetic rats.
Journal of food biochemistry, , Volume: 43, Issue:3, 2019

Alendronate-induced gastric damage in normoglycemic and hyperglycemic rats is reversed by metformin.
European journal of pharmacology, , Aug-05, Volume: 856, 2019

Nesfatin-1 improves oxidative skin injury in normoglycemic or hyperglycemic rats.
Peptides, , Volume: 78, 2016

Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus.
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Chard (Beta vulgaris L. var. cicla) extract ameliorates hyperglycemia by increasing GLUT2 through Akt2 and antioxidant defense in the liver of rats.
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β(2)-Adrenoreceptor blockade improves early posttrauma hyperglycemia and pulmonary injury in obese rats.
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Propofol attenuates renal ischemia-reperfusion injury aggravated by hyperglycemia.
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Neutrophil dysfunction induced by hyperglycemia: modulation of myeloperoxidase activity.
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The effects of diabetes and/or polymicrobial sepsis on the status of antioxidant enzymes and pro-inflammatory cytokines on heart, liver, and lung of ovariectomized rats.
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Postprandial endothelial function, inflammation, and oxidative stress in obese children and adolescents.
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Increased O-linked beta-N-acetylglucosamine levels on proteins improves survival, reduces inflammation and organ damage 24 hours after trauma-hemorrhage in rats.
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Hyperglycemia and oxidative stress strengthen the association between myeloperoxidase and blood pressure.
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Haemolysis and lipemia interfere with resistin and myeloperoxidase BioVendor ELISA assays.
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The effect of menopause on the relationship between hyperlipidemia and periodontal disease via salivary 8-hydroxy-2'-deoxyguanosine and myeloperoxidase levels.
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Paraoxonase-1 and myeloperoxidase correlate with vascular biomarkers in overweight patients with newly diagnosed untreated hyperlipidaemia.
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Paraoxonase-1 arylesterase activity is an independent predictor of myeloperoxidase levels in overweight patients with or without cardiovascular complications.
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Statins and IL-1β, IL-10, and MPO Levels in Gingival Crevicular Fluid: Preliminary Results.
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Myeloperoxidase-derived hypochlorous acid promotes ox-LDL-induced senescence of endothelial cells through a mechanism involving β-catenin signaling in hyperlipidemia.
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In vivo examination of 111In-bis-5HT-DTPA to target myeloperoxidase in atherosclerotic ApoE knockout mice.
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Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males.
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Effect of Antibiotics on Polymorphonuclear Leukocyte Functions and Myeloperoxidase Activity, Glutathione and Malondialdehyde Levels in Allergic Asthma.
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Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.
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Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy.
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High plasma concentration of myeloperoxidase in cirrhosis: a possible marker of hypersplenism.
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Inflammation, Lymphatics, and Cardiovascular Disease: Amplification by Chronic Kidney Disease.
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A neutrophil signature is strongly associated with increased cardiovascular risk in gout.
Rheumatology (Oxford, England), , 06-18, Volume: 60, Issue:6, 2021

Anti-neutrophil cytoplasmic antibody associated glomerulonephritis complicating treatment with hydralazine.
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The Impact of Hypertension and Metabolic Syndrome on Nitrosative Stress and Glutathione Metabolism in Patients with Morbid Obesity.
Oxidative medicine and cellular longevity, , Volume: 2020, 2020

SNP rs2243828 in MPO associated with myeloperoxidase level and atrial fibrillation risk in Chinese Han population.
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Microvascular disease confers additional risk to COVID-19 infection.
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Pharmacological myeloperoxidase (MPO) inhibition in an obese/hypertensive mouse model attenuates obesity and liver damage, but not cardiac remodeling.
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Hydralazine-induced MPO-ANCA Renal-Limited Vasculitis Masquerading as Lupus Nephritis.
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Entire Peroxidation Reaction System of Myeloperoxidase Correlates with Progressive Low-Density Lipoprotein Modifications via Reactive Aldehydes in Atherosclerotic Patients with Hypertension.
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Barnidipine ameliorates the vascular and renal injury in L-NAME-induced hypertensive rats.
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Evaluation of systemic levels of neutrophilic enzymes in patients with hypertension and chronic periodontitis.
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CD4+ T cells are important mediators of oxidative stress that cause hypertension in response to placental ischemia.
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Hyperglycemia and oxidative stress strengthen the association between myeloperoxidase and blood pressure.
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A 73-year-old man with confusion, fever, and positive MPO-ANCA.
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Is there an answer?
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Octreotide: a new approach to the management of acute abdominal hypertension.
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Naringenin adds to the protective effect of L-arginine in monocrotaline-induced pulmonary hypertension in rats: favorable modulation of oxidative stress, inflammation and nitric oxide.
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Inhibiting myeloperoxidase prevents onset and reverses established high-fat diet-induced microvascular insulin resistance.
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Urinary Matrix Metalloproteinase 7 Activated by Oxidative Stress Predicts Kidney Prognosis in Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Antioxidants & redox signaling, , Volume: 37, Issue:4-6, 2022

Clinical features and prognosis of MPO-ANCA and anti-GBM double-seropositive patients.
Frontiers in immunology, , Volume: 13, 2022

Antibody subtypes and titers predict clinical outcomes in ANCA-associated vasculitis.
Rheumatology international, , Volume: 41, Issue:5, 2021

Glomerular Immune Deposition in MPO-ANCA Associated Glomerulonephritis Is Associated With Poor Renal Survival.
Frontiers in immunology, , Volume: 12, 2021

A Case of Dual Positive Glomerulonephritis With Plasma Cell Dyscrasia.
The American journal of medicine, , Volume: 133, Issue:8, 2020

Prognostic role of circulating neutrophil extracellular traps levels for long-term mortality in new end-stage renal disease patients.
Clinical immunology (Orlando, Fla.), , Volume: 210, 2020

Hyperuricemia is associated with decreased renal function and occurrence of end-stage renal disease in patients with microscopic polyangiitis and granulomatosis with polyangiitis: a retrospective study.
Rheumatology international, , Volume: 40, Issue:7, 2020

Can antineutrophil cytoplasmic antibody positivity at diagnosis predict the poor outcomes of Sjögren's syndrome?
Rheumatology international, , Volume: 40, Issue:7, 2020

The complexity of classifying ANCA-associated small-vessel vasculitis in actual clinical practice: data from a multicenter retrospective survey.
Rheumatology international, , Volume: 40, Issue:2, 2020

Serum Myeloperoxidase, C-reactive Protein and α1-acid Glycoprotein: Insights about Cardiovascular Risk in End-stage Renal Disease.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, , Volume: 128, Issue:11, 2020

High anti-neutrophil cytoplasmic antibody titers are associated with the requirement of permanent dialysis in patients with myeloperoxidase-ANCA-associated vasculitis.
Journal of the Formosan Medical Association = Taiwan yi zhi, , Volume: 118, Issue:10, 2019

Comparative Cardiac Safety of Selective Serotonin Reuptake Inhibitors among Individuals Receiving Maintenance Hemodialysis.
Journal of the American Society of Nephrology : JASN, , Volume: 30, Issue:4, 2019

Clinical and histopathological prognostic factors affecting the renal outcomes in childhood ANCA-associated vasculitis.
Pediatric nephrology (Berlin, Germany), , Volume: 34, Issue:5, 2019

Impact of Proteinase 3 versus Myeloperoxidase Positivity on Risk of End-Stage Renal Disease in ANCA-Associated Glomerulonephritis Stratified by Histological Classification: A Population-Based Cohort Study.
Disease markers, , Volume: 2018, 2018

Myeloperoxidase-derived oxidants damage artery wall proteins in an animal model of chronic kidney disease-accelerated atherosclerosis.
The Journal of biological chemistry, , 05-11, Volume: 293, Issue:19, 2018

The influence of body mass index on the accumulation of advanced glycation end products in hemodialysis patients.
European journal of clinical nutrition, , Volume: 69, Issue:3, 2015

ANCA positive crescentic glomerulonephritis outcome in a Central East European cohort: a retrospective study.
BMC nephrology, , Jun-30, Volume: 16, 2015

Treatment of severe renal disease in ANCA positive and negative small vessel vasculitis with rituximab.
American journal of nephrology, , Volume: 41, Issue:4-5, 2015

Changes of thioredoxin, oxidative stress markers, inflammation and muscle/renal damage following intensive endurance exercise.
Exercise immunology review, , Volume: 21, 2015

ANCA serotype and histopathological classification for the prediction of renal outcome in ANCA-associated glomerulonephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 29, Issue:9, 2014

Pomegranate juice intake attenuates the increase in oxidative stress induced by intravenous iron during hemodialysis.
Nutrition research (New York, N.Y.), , Volume: 33, Issue:6, 2013

L21. Kidneys in ANCA-associated vasculitis: what to learn from biopsies?
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The myeloperoxidase product hypochlorous acid generates irreversible high-density lipoprotein receptor inhibitors.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 33, Issue:5, 2013

Positive association between plasma levels of oxidized low-density lipoprotein and myeloperoxidase after hemodialysis in patients with diabetic end-stage renal disease.
Hemodialysis international. International Symposium on Home Hemodialysis, , Volume: 17, Issue:4, 2013

Renal survival in proteinase 3 and myeloperoxidase ANCA-associated systemic vasculitis.
Clinical journal of the American Society of Nephrology : CJASN, , Volume: 8, Issue:10, 2013

Myeloperoxidase and progression of aortic valve stenosis in patients undergoing hemodialysis.
The Journal of heart valve disease, , Volume: 22, Issue:5, 2013

Clinical trial for Japanese patients with myeloperoxidase anti-neutrophil cytoplasmic antibody-associated vasculitis: the JMAAV study.
Clinical and experimental nephrology, , Volume: 17, Issue:5, 2013

Evaluation of the newly proposed simplified histological classification in Japanese cohorts of myeloperoxidase-anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in comparison with other Asian and European cohorts.
Clinical and experimental nephrology, , Volume: 17, Issue:5, 2013

The role of xanthine oxidase in hemodialysis-induced oxidative injury: relationship with nutritional status.
Oxidative medicine and cellular longevity, , Volume: 2013, 2013

Clinical outcomes of Japanese MPO-ANCA-related nephritis: significance of initial renal death for survival.
Internal medicine (Tokyo, Japan), , Volume: 51, Issue:15, 2012

Recurrence of anti-neutrophil cytoplasmic antibody vasculitis in the kidney allograft.
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[Sjögren's syndrome and vasculitis associated with antineutrophil cytoplasmic antibodies].
Medicina clinica, , Nov-17, Volume: 139, Issue:12, 2012

Serum ratio of soluble triggering receptor expressed on myeloid cells-1 to creatinine is a useful marker of infectious complications in myeloperoxidase-antineutrophil cytoplasmic antibody-associated renal vasculitis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 26, Issue:3, 2011

Ethylene-vinyl alcohol copolymer dialyzer membrane reduces protein oxidation in hemodialysis patients.
Renal failure, , Volume: 33, Issue:4, 2011

The importance of oxidative stress in patients with chronic renal failure whose hypertension is treated with peritoneal dialysis.
Cell biochemistry and function, , Volume: 29, Issue:3, 2011

Prognostic value of plasma myeloperoxidase in ESRD patients.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 56, Issue:5, 2010

Plasma myeloperoxidase, NT-proBNP, and troponin-I in patients on CAPD compared with those on regular hemodialysis.
Hemodialysis international. International Symposium on Home Hemodialysis, , Volume: 14, Issue:3, 2010

Evaluation of oxidative and nitrosative stress in hemodialysis patients.
Minerva medica, , Volume: 101, Issue:5, 2010

Classification of clinical subtypes, patient survival, kidney prognosis, and relapse in patients with MPO-ANCA-associated vasculitis: a single-center experience.
Modern rheumatology, , Volume: 19, Issue:4, 2009

Nitric oxide metabolites, leukocyte activation markers and oxidative status in dialyzed subjects.
Blood purification, , Volume: 27, Issue:2, 2009

Elastase, myeloperoxidase, nitric oxide metabolites and oxidative status in subjects with clinical stable chronic renal failure on conservative treatment.
Clinical hemorheology and microcirculation, , Volume: 43, Issue:3, 2009

Tipping the redox balance of oxidative stress in fibrogenic pathways in chronic kidney disease.
Pediatric nephrology (Berlin, Germany), , Volume: 24, Issue:12, 2009

Assessment of myeloperoxidase and oxidative alpha1-antitrypsin in patients on hemodialysis.
Clinical journal of the American Society of Nephrology : CJASN, , Volume: 4, Issue:1, 2009

Compositional and oxidative analysis in the saliva and serum of predialysis chronic kidney disease patients and end-stage renal failure patients on peritoneal dialysis.
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Oxidative stress and asymmetric dimethylarginine are associated with cardiovascular complications in hemodialysis patients: improvements by L-arginine intake.
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Functional polymorphism of the myeloperoxidase gene in hypertensive nephrosclerosis dialysis patients.
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Myeloperoxidase serves as a marker of oxidative stress during single haemodialysis session using two different biocompatible dialysis membranes.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 21, Issue:2, 2006

Respective role of uraemic toxins and myeloperoxidase in the uraemic state.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 21, Issue:6, 2006

[Rapid recurrence of ANCA-MPO positive vasculitis after non-heart beating donor renal transplantation].
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Statin treatment and diabetes affect myeloperoxidase activity in maintenance hemodialysis patients.
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Primed peripheral polymorphonuclear leukocyte: a culprit underlying chronic low-grade inflammation and systemic oxidative stress in chronic kidney disease.
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Coexistence of anti-glomerular basement membrane antibodies and myeloperoxidase-ANCAs in crescentic glomerulonephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 46, Issue:2, 2005

The role of oxidative stress-altered lipoprotein structure and function and microinflammation on cardiovascular risk in patients with minor renal dysfunction.
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Genetic determination of TNF and myeloperoxidase production in dialyzed patients with diabetic nephropathy.
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Peripheral blood myeloperoxidase activity increases during hemodialysis.
Kidney international, , Volume: 64, Issue:2, 2003

Coronary artery disease in end-stage renal disease: no longer a simple plumbing problem.
Journal of the American Society of Nephrology : JASN, , Volume: 14, Issue:7, 2003

Subarachnoid hemorrhages in vasculitis.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 42, Issue:3, 2003

Proinflammatory genotype of interleukin-1 and interleukin-1 receptor antagonist is associated with ESRD in proteinase 3-ANCA vasculitis patients.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 41, Issue:5, 2003

A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients.
Kidney international. Supplement, , Issue:84, 2003

Polymorphisms of tumor necrosis factor and myeloperoxidase genes in patients with chronic renal failure on peritoneal dialysis.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology, , Volume: 7, Issue:3-4, 2003

Sirolimus lowers myeloperoxidase and p-ANCA titers in a pediatric patient before kidney transplantation.
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[A case of ANCA-associated glomerulonephritis without extrarenal symptoms with disease flare after starting dialysis].
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Manifestations of oxidant stress in uremia.
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Necrotizing glomerulonephritis associated with antimyeloperoxidase antibodies in a renal transplant recipient with renal failure of unknown origin.
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Peroxidase activity in peritoneal macrophages of patients with terminal renal failure treated by intermittent peritoneal dialysis.
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Linking oxidative stress and inflammation in kidney disease: which is the chicken and which is the egg?
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Renal outcome of kidney-transplantation in Korean recipients with ANCA-associated vasculitis.
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Philadelphia chromosome-positive blastic leukaemia: ultrastructural and ultracytochemical evidence of basophil and mast cell differentiation.
British journal of haematology, , Volume: 52, Issue:4, 1982

Symposium: classification of leukemia. 1. The classification of acute leukemia.
Pathology, , Volume: 14, Issue:3, 1982

[Comparative value of benzidine and alpha-naphthol for peroxidase reaction in leukemic cell (author's transl)].
Pathologie-biologie, , Volume: 29, Issue:3, 1981

Terminal deoxynucleotidyl transferase-positive acute myeloblastic leukemia.
American journal of hematology, , Volume: 10, Issue:3, 1981

[Morphology and cytochemistry of acute leukaemia (author's transl)].
Sangre, , Volume: 26, Issue:5-C, 1981

Significance of Phi bodies in acute leukaemia.
Journal of clinical pathology, , Volume: 34, Issue:2, 1981

Cytochemical markers of differentiation in acute leukemia.
Cancer research, , Volume: 41, Issue:11 Pt 2, 1981

Simple procedure of isolation of myeloperoxidase from leukocytes, pus and bone marrow cells.
Acta medica Polona, , Volume: 21, Issue:2, 1980

[Myeloperoxidase activity and the digestive capacity of the neutrophils in acute myeloblastic leukemia].
Problemy gematologii i perelivaniia krovi, , Volume: 24, Issue:1, 1979

Ultrastructural study of leukemic cell phagocytosis using the myeloperoxidase reaction.
Tumori, , Oct-31, Volume: 65, Issue:5, 1979

Monocyte and granulocyte defect in chronic lymphocytic leukemia.
The American journal of pathology, , Volume: 95, Issue:1, 1979

Peripheral blood neutrophils in children in remission of acute lymphoblastic leukaemia. Cytochemical investigations.
Acta medica Polona, , Volume: 18, Issue:1, 1977

Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
British journal of haematology, , Volume: 33, Issue:4, 1976

[Morphological and certain cytochemical indicators in acute leukemia].
Laboratornoe delo, , Issue:5, 1975

Immunoglobulin and granulocyte cytochemical reactions in L-asparaginase treated children with acute lymphoblastic leukemia.
Medecine interne, , Volume: 14, Issue:3

Sudan black B and peroxidase positivity in cultured lymphoid cells from patients with B-type chronic lymphocytic leukemia.
Haematologica, , Volume: 70, Issue:5

[A cell-line with 27 chromosomes in a human acute leukemia (author's transl)].
Nouvelle revue francaise d'hematologie, , Volume: 15, Issue:1

Alkaline phosphatase is a useful cytochemical marker for the diagnosis of acute myelomonocytic and monocytic leukemia in the dog.
Veterinary clinical pathology, , Volume: 44, Issue:1, 2015

Acute monoblastic leukemia with t(8;16): a distinct clinicopathologic entity; report of a case and review of the literature.
American journal of hematology, , Volume: 66, Issue:3, 2001

Granulocyte-colony stimulating factor, granulocyte-macrophage colony stimulating factor and interleukin 4 induce differentiation in the U-937 human monocytic leukemia cell line.
Leukemia & lymphoma, , Volume: 22, Issue:1-2, 1996

Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3.
Leukemia, , Volume: 10, Issue:6, 1996

Distinct lysozyme content in different subtypes of acute myeloid leukaemic cells: an ultrastructural immunogold study.
British journal of haematology, , Volume: 88, Issue:2, 1994

Human cell lines U-937, THP-1 and Mono Mac 6 represent relatively immature cells of the monocyte-macrophage cell lineage.
Leukemia, , Volume: 8, Issue:9, 1994

Ultrastructural localization of myeloperoxidase activity in acute monoblastic leukemia.
International journal of hematology, , Volume: 59, Issue:1, 1993

Quantitative enzyme determination in acute myeloid leukemia.
Leukemia research, , Volume: 15, Issue:6, 1991

Auer rods and myeloperoxidase: an approach for investigating changes at the molecular level in acute myeloid leukaemia (AML).
Medical hypotheses, , Volume: 30, Issue:3, 1989

[The cytochemistry of granulocytes in acute leukemia].
Gematologiia i transfuziologiia, , Volume: 30, Issue:4, 1985

Bimodal differentiation prospectives for promyelocytes.
Journal of the National Cancer Institute, , Volume: 75, Issue:2, 1985

Studies on aminopeptidase activity in acute non-lymphocytic leukemia. The relation to peroxidase reaction.
Acta pathologica japonica, , Volume: 33, Issue:3, 1983

Lysosomal granules in leukemic monocytes and their relation to maturation stages.
Haematology and blood transfusion, , Volume: 27, 1981

Ultrastructural cytochemistry of leukaemic cells: characterization of the early small granules of monoblasts.
British journal of haematology, , Volume: 45, Issue:2, 1980

Ultrastructural study of leukemic cell phagocytosis using the myeloperoxidase reaction.
Tumori, , Oct-31, Volume: 65, Issue:5, 1979

[Myeloperoxidase activity and the digestive capacity of the neutrophils in acute myeloblastic leukemia].
Problemy gematologii i perelivaniia krovi, , Volume: 24, Issue:1, 1979

Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
British journal of haematology, , Volume: 33, Issue:4, 1976

Significance of transmission electron microscopy in subtyping of monocytic leukemia.
Ultrastructural pathology, , Volume: 33, Issue:2

Constitutive overexpression of the c-fos gene in radiation-induced granulocytic leukemia in mice.
Radiation research, , Volume: 135, Issue:3, 1993

Neutrophil dysfunction in the pathogenesis of cystic fibrosis.
Blood, , 04-28, Volume: 139, Issue:17, 2022

Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation.
Oxidative medicine and cellular longevity, , Volume: 2016, 2016

Riparin A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration.
Chemico-biological interactions, , Mar-05, Volume: 229, 2015

Genetic variation associates with susceptibility for cigarette smoke-induced neutrophilia in mice.
American journal of physiology. Lung cellular and molecular physiology, , Apr-01, Volume: 308, Issue:7, 2015

Carvacryl acetate, a derivative of carvacrol, reduces nociceptive and inflammatory response in mice.
Life sciences, , Jan-14, Volume: 94, Issue:1, 2014

Low-dose combination of alendronate and atorvastatin reduces ligature-induced alveolar bone loss in rats.
Journal of periodontal research, , Volume: 49, Issue:1, 2014

Growth arrest-specific protein 6 attenuates neutrophil migration and acute lung injury in sepsis.
Shock (Augusta, Ga.), , Volume: 40, Issue:6, 2013

Anti-inflammatory effect of a sulphated polysaccharide fraction extracted from the red algae Hypnea musciformis via the suppression of neutrophil migration by the nitric oxide signalling pathway.
The Journal of pharmacy and pharmacology, , Volume: 65, Issue:5, 2013

Proinflammatory activity of an alginate isolated from Sargassum vulgare.
Carbohydrate polymers, , Jan-30, Volume: 92, Issue:1, 2013

Staphylococcus aureus infection of the rabbit cornea following topical administration.
Current eye research, , Volume: 37, Issue:12, 2012

Diagnostic assays for myeloperoxidase deficiency.
Methods in molecular biology (Clifton, N.J.), , Volume: 412, 2007

Disorders of neutrophil function: an overview.
Methods in molecular biology (Clifton, N.J.), , Volume: 412, 2007

Myeloperoxidase deficiency associated with atypical oral candidiasis: A clinical report.
The Journal of prosthetic dentistry, , Volume: 82, Issue:3, 1999

[Myeloperoxidase deficiency].
Ryoikibetsu shokogun shirizu, , Issue:21 Pt 2, 1998

Primary inherited defects in neutrophil function: etiology and treatment.
Seminars in hematology, , Volume: 34, Issue:4, 1997

Recurrent lipoatrophic panniculitis of children.
Journal of the European Academy of Dermatology and Venereology : JEADV, , Volume: 31, Issue:3, 2017

Low-dose combination of alendronate and atorvastatin reduces ligature-induced alveolar bone loss in rats.
Journal of periodontal research, , Volume: 49, Issue:1, 2014

Susceptibility quantitative trait loci for pathogenic leucocytosis in SCG/Kj mice, a spontaneously occurring crescentic glomerulonephritis and vasculitis model.
Clinical and experimental immunology, , Volume: 177, Issue:1, 2014

The effects of G-CSF-induced mobilization of progenitor cells are limited by ADMA.
International journal of cardiology, , Sep-03, Volume: 143, Issue:3, 2010

Differential pattern of human blood neutrophil activation after stimulation with organic dust in vitro and in vivo.
Journal of occupational and environmental medicine, , Volume: 49, Issue:2, 2007

Protective effects of Tacrolimus, a calcineurin inhibitor, in experimental periodontitis in rats.
Archives of oral biology, , Volume: 52, Issue:9, 2007

IL-8 and airway neutrophilia in children with gastroesophageal reflux and asthma-like symptoms.
Respiratory medicine, , Volume: 100, Issue:2, 2006

Induction of colitis in young rats by dextran sulfate sodium.
Digestive diseases and sciences, , Volume: 50, Issue:1, 2005

MPXI and early neutrophilia: new potential therapeutic biomarkers for recombinant human granulocyte colony-stimulating factor.
Journal of clinical laboratory analysis, , Volume: 12, Issue:1, 1998

Nasal neutrophilia and release of myeloperoxidase induced by nasal challenge with platelet activating factor: different degrees of responsiveness in atopic and nonatopic subjects.
The Journal of allergy and clinical immunology, , Volume: 97, Issue:4, 1996

BAL neutrophilia in asthmatic patients. A by-product of eosinophil recruitment?
Chest, , Volume: 110, Issue:5, 1996

Inhibition of calcium-dependent nitric oxide synthase causes ileitis and leukocytosis in guinea pigs.
Digestive diseases and sciences, , Volume: 39, Issue:6, 1994

Positive bacterial culture of semen from infertile men with asymptomatic leukocytospermia.
International journal of fertility and women's medicine, , Volume: 47, Issue:6

Genetic disorders of lysosomes.
Progress in medical genetics, , Volume: 1, 1976

A case report of progressive multifocal leukoencephalopathy during steroid treatment for ANCA-associated renal vasculitis.
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[A case of MPO-ANCA related vasculitis with transient leukoencephalopathy and multiple cerebral hemorrhage].
Rinsho shinkeigaku = Clinical neurology, , Volume: 36, Issue:9, 1996

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Metabolic Activation of Tofacitinib Mediated by Myeloperoxidase
Chemical research in toxicology, , 12-16, Volume: 32, Issue:12, 2019

Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children.
Disease markers, , Volume: 2018, 2018

The reduction of oxidative stress by nanocomposite Fullerol decreases mucositis severity and reverts leukopenia induced by Irinotecan.
Pharmacological research, , Volume: 107, 2016

Protective effects of intravenous immunoglobulin and antimicrobial agents on acute pneumonia in leukopenic mice.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, , Volume: 22, Issue:4, 2016

Effect of atorvastatin on 5-fluorouracil-induced experimental oral mucositis.
Cancer chemotherapy and pharmacology, , Volume: 67, Issue:5, 2011

Role of platelet-activating factor in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice.
Cancer chemotherapy and pharmacology, , Volume: 68, Issue:3, 2011

In vitro and in vivo immunostimulatory activity of Woodfordia fruticosa flowers on non-specific immunity.
Pharmaceutical biology, , Volume: 48, Issue:9, 2010

Effect of Ulinastatin, a human urinary trypsin inhibitor, on the oleic acid-induced acute lung injury in rats via the inhibition of activated leukocytes.
Injury, , Volume: 36, Issue:3, 2005

Macrophage inflammatory protein-2 mediates the bowel injury induced by platelet-activating factor.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 287, Issue:6, 2004

[Morphofunctional state of neutrophil granulocytes in Chernobyl nuclear plant accident clean-up workers with persistent leukopenia].
Likars'ka sprava, , Issue:2, 2002

[Clinical patameters associated with oxygen-dependent metabolism in neutrophils in patients with systemic lupus erythematosus and leukocytopenia].
Likars'ka sprava, , Issue:6, 2000

Potent protective effects of melatonin on experimental spinal cord injury.
Spine, , Apr-01, Volume: 25, Issue:7, 2000

Neuroprotection by recombinant thrombomodulin.
Thrombosis and haemostasis, , Volume: 83, Issue:3, 2000

Systemic perfluorocarbons suppress the acute lung inflammation after gastric acid aspiration in rats.
Anesthesia and analgesia, , Volume: 90, Issue:2, 2000

Activated neutrophils impair gastric cytoprotection role of neutrophil elastase.
Digestive diseases and sciences, , Volume: 45, Issue:6, 2000

Gastric prostacyclin (PGI2) prevents stress-induced gastric mucosal injury in rats primarily by inhibiting leukocyte activation.
Prostaglandins & other lipid mediators, , Volume: 57, Issue:5-6, 1999

Activated protein C reduces the severity of compression-induced spinal cord injury in rats by inhibiting activation of leukocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-15, Volume: 18, Issue:4, 1998

Role of neutrophil elastase in compression-induced spinal cord injury in rats.
Brain research, , Jul-20, Volume: 799, Issue:2, 1998

Role of neutrophil elastase in stress-induced gastric mucosal injury in rats.
The Journal of laboratory and clinical medicine, , Volume: 132, Issue:5, 1998

Reduction of spinal cord injury by administration of iloprost, a stable prostacyclin analog.
Journal of neurosurgery, , Volume: 86, Issue:6, 1997

[Age- and sex-related chemical sensitivity in white rats].
Meditsina truda i promyshlennaia ekologiia, , Issue:12, 1997

Gabexate mesilate, a synthetic protease inhibitor, prevents compression-induced spinal cord injury by inhibiting activation of leukocytes in rats.
Critical care medicine, , Volume: 25, Issue:5, 1997

Novel role of prostacyclin in stress-induced gastric mucosal lesion formation in rats.
The Journal of laboratory and clinical medicine, , Volume: 129, Issue:6, 1997

Enhancement of the leukocyte-endothelial cell interaction in collecting venules of skeletal muscle by protamine.
The Journal of thoracic and cardiovascular surgery, , Volume: 113, Issue:4, 1997

Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats.
Blood, , Jan-15, Volume: 87, Issue:2, 1996

A case of total peripheral aneosinophilia associated with complete deficiency of myeloperoxidase.
Acta clinica Belgica, , Volume: 51, Issue:4, 1996

Improved survival and reversal of endothelial dysfunction by the 21-aminosteroid, U-74389G in splanchnic ischaemia-reperfusion injury in the rat.
British journal of pharmacology, , Volume: 115, Issue:3, 1995

Leukocytes mediate acid aspiration-induced multiorgan edema.
Surgery, , Volume: 114, Issue:1, 1993

Leukocytes in carbon monoxide-mediated brain oxidative injury.
Toxicology and applied pharmacology, , Volume: 123, Issue:2, 1993

Platelet activating factor interaction with tumor necrosis factor in myocardial ischaemia-reperfusion injury.
Journal of lipid mediators, , Volume: 8, Issue:1, 1993

Sepsis- and endotoxin-induced increase in organ glucose uptake in leukocyte-depleted rats.
The American journal of physiology, , Volume: 263, Issue:6 Pt 2, 1992

[The hematological and biochemical changes in workers exposed to benzol].
Problemi na khigienata, , Volume: 17, 1992

Effect of cuprophan, hemophan and polysulfone membranes on the oxidative metabolism, degranulation reaction, enzyme release and pulmonary sequestration of granulocytes.
Contributions to nephrology, , Volume: 74, 1989

[The detection of rare cellular events using scanning cytometry].
Pathologie-biologie, , Volume: 36, Issue:1, 1988

Relationship between leukopenia and bone marrow myeloperoxidase in the rat treated with propylthiouracil.
Japanese journal of pharmacology, , Volume: 36, Issue:2, 1984

Automated cytochemical staining and inflammation. Further assessment of the "left shift".
American journal of clinical pathology, , Volume: 78, Issue:4, 1982

Enzymatic deficiencies of the immune system cells in patients with cancer of the larynx and other malignancies.
Auris, nasus, larynx, , Volume: 12, Issue:1, 1985

The association between immunoexpression levels of oxidant and antioxidant enzymes and lip squamous cell carcinoma.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, , Volume: 126, Issue:5, 2018

Granulocytic sarcoma of the lips: report of an unusual case.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, , Volume: 105, Issue:1, 2008

Diagnostic significance of myeloperoxidase assay in neuronal ceroid-lipofuscinoses (Batten-Vogt syndrome).
Neurology, , Volume: 28, Issue:9 Pt 1, 1978

Cytosome morphology and distribution of generalized ceroidlipofuscinosis in a twenty-eight month old boy with normal myeloperoxidase activity.
Neuropadiatrie, , Volume: 6, Issue:3, 1975

Thyroid peroxidase deficiency in Batten-Spielmeyer-Vogt disease.
Archives of pathology, , Volume: 99, Issue:8, 1975

IFN-γ protects from apoptotic neutrophil-mediated tissue injury during acute Listeria monocytogenes infection.
European journal of immunology, , Volume: 48, Issue:9, 2018

Involvement of Toso in activation of monocytes, macrophages, and granulocytes.
Proceedings of the National Academy of Sciences of the United States of America, , Feb-12, Volume: 110, Issue:7, 2013

Comparative study of protective effects of chitin, chitosan, and N-acetyl chitohexaose against Pseudomonas aeruginosa and Listeria monocytogenes infections in mice.
Biological & pharmaceutical bulletin, , Volume: 26, Issue:6, 2003

Complementary adhesion molecules promote neutrophil-Kupffer cell interaction and the elimination of bacteria taken up by the liver.
Journal of immunology (Baltimore, Md. : 1950), , Jan-01, Volume: 168, Issue:1, 2002

Distinction between 'inflammatory' and 'immune' macrophages killing Listeria monocytogenes in murine infection.
Immunology and cell biology, , Volume: 68 ( Pt 5), 1990

[Age-related immunodeficiencies of the neutrophilic granulocyte system].
Arkhiv patologii, , Volume: 52, Issue:6, 1990

Heterogeneity of peritoneal macrophages.
The Tokai journal of experimental and clinical medicine, , Volume: 9, Issue:5-6, 1984

Liver injury and abscess formation in secondary murine peritonitis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 60, Issue:4, 2011

Leukocyte myeloperoxidase deficiency and diabetes mellitus associated with Candida albicans liver abscess.
The American journal of medicine, , Volume: 66, Issue:1, 1979

[Hereditary myeloperoxidase deficiency. Clinical, biological and genetic study].
Schweizerische medizinische Wochenschrift, , Oct-15, Volume: 107, Issue:41, 1977

Neutrophil extracellular traps and MPO in models of susceptibility and resistance against Entamoeba histolytica.
Parasite immunology, , Volume: 42, Issue:6, 2020

Different behavior of myeloperoxidase in two rodent amoebic liver abscess models.
PloS one, , Volume: 12, Issue:8, 2017

A review of the proposed role of neutrophils in rodent amebic liver abscess models.
Parasite (Paris, France), , Volume: 23, 2016

Innate immunity prevents tissue invasion by Entamoeba histolytica.
Canadian journal of microbiology, , Volume: 54, Issue:12, 2008

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Relationship between disease severity and myeloperoxidase in chronic viral hepatitis: a prospective study.
Biomarkers in medicine, , Volume: 17, Issue:6, 2023

Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease.
American journal of physiology. Gastrointestinal and liver physiology, , Oct-01, Volume: 323, Issue:4, 2022

Neutrophil extracellular traps in patients with liver cirrhosis and hepatocellular carcinoma.
Scientific reports, , 09-09, Volume: 11, Issue:1, 2021

Myeloperoxidase and calprotectin; Any role as non-invasive markers for the prediction of ınflammation and fibrosis in non-alcoholic steatohepatitis?
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, , Volume: 31, Issue:10, 2020

Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice.
Digestive diseases and sciences, , Volume: 64, Issue:9, 2019

Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats.
International journal of pharmaceutics, , Sep-05, Volume: 548, Issue:1, 2018

Treatment with milk thistle extract (Silybum marianum), ursodeoxycholic acid, or their combination attenuates cholestatic liver injury in rats: Role of the hepatic stem cells.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, , Volume: 28, Issue:6, 2017

[no title available]
Applied physics. B, Lasers and optics, , Volume: 122, Issue:12, 2016

Carvedilol Improves Inflammatory Response, Oxidative Stress and Fibrosis in the Alcohol-Induced Liver Injury in Rats by Regulating Kuppfer Cells and Hepatic Stellate Cells.
PloS one, , Volume: 11, Issue:2, 2016

Myeloperoxidase-Hepatocyte-Stellate Cell Cross Talk Promotes Hepatocyte Injury and Fibrosis in Experimental Nonalcoholic Steatohepatitis.
Antioxidants & redox signaling, , Dec-01, Volume: 23, Issue:16, 2015

Myeloperoxidase gene polymorphism predicts fibrosis severity in women with hepatitis C.
Human immunology, , Volume: 75, Issue:8, 2014

Protective effects of rutin on liver injury induced by biliary obstruction in rats.
Free radical biology & medicine, , Volume: 73, 2014

The optimal time window of ischemic preconditioning (IPC) on the reperfusion injury in moderate to severe hepatocirrhosis in rats.
Annals of clinical and laboratory science, ,Winter, Volume: 43, Issue:1, 2013

Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice.
PloS one, , Volume: 7, Issue:12, 2012

A variant in myeloperoxidase promoter hastens the emergence of hepatocellular carcinoma in patients with HCV-related cirrhosis.
Journal of hepatology, , Volume: 56, Issue:2, 2012

Combination therapy with taurine, epigallocatechin gallate and genistein for protection against hepatic fibrosis induced by alcohol in rats.
Biological & pharmaceutical bulletin, , Volume: 35, Issue:10, 2012

Plasma myeloperoxidase activity and apolipoprotein A-1 expression in chronic hepatitis B patients.
Archives of Iranian medicine, , Volume: 14, Issue:4, 2011

Redox balance in the pathogenesis of nonalcoholic fatty liver disease: mechanisms and therapeutic opportunities.
Antioxidants & redox signaling, , Sep-01, Volume: 15, Issue:5, 2011

Do genetic variations in antioxidant enzymes influence the course of hereditary hemochromatosis?
Antioxidants & redox signaling, , Jul-01, Volume: 15, Issue:1, 2011

Clinical significance of a myeloperoxidase gene polymorphism and inducible nitric oxide synthase expression in cirrhotic patients with hepatopulmonary syndrome.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, , Volume: 30, Issue:4, 2010

Oxidant and antioxidant of arylesterase and paraoxonase as biomarkers in patients with hepatitis C virus.
Clinical biochemistry, , Volume: 42, Issue:13-14, 2009

Ghrelin alleviates biliary obstruction-induced chronic hepatic injury in rats.
Regulatory peptides, , Feb-07, Volume: 146, Issue:1-3, 2008

Pomegranate peel extract prevents liver fibrosis in biliary-obstructed rats.
The Journal of pharmacy and pharmacology, , Volume: 59, Issue:9, 2007

Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis.
Journal of hepatology, , Volume: 42, Issue:6, 2005

Tezosentan, an endothelin receptor antagonist, limits liver injury in endotoxin challenged cirrhotic rats.
Gut, , Volume: 53, Issue:12, 2004

Deficient phospholipase C activity in blood polimorphonuclear neutrophils from patients with liver cirrhosis.
Journal of hepatology, , Volume: 40, Issue:5, 2004

A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection.
Genes and immunity, , Volume: 3, Issue:6, 2002

Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells.
The Journal of biological chemistry, , Jul-06, Volume: 276, Issue:27, 2001

The role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride.
Toxicology and applied pharmacology, , Dec-01, Volume: 177, Issue:2, 2001

Patients with stable uncomplicated cirrhosis have normal neutrophil function.
Journal of gastroenterology and hepatology, , Volume: 15, Issue:11, 2000

Sensitive enzymatic assay for erythrocyte creatine with production of methylene blue.
Clinical chemistry, , Volume: 44, Issue:7, 1998

High plasma concentration of myeloperoxidase in cirrhosis: a possible marker of hypersplenism.
Hepatology (Baltimore, Md.), , Volume: 18, Issue:6, 1993

Decreased production of active oxygen species by neutrophils in patients with liver cirrhosis and hepatocellular carcinoma.
Gastroenterologia Japonica, , Volume: 28, Issue:4, 1993

Plasma myeloperoxidase and lactoferrin measured by radioimmunoassay: relations to neutrophil kinetics.
Acta medica Scandinavica, , Volume: 198, Issue:6, 1975

Is intestinal oxidative stress involved in patients with compensated liver cirrhosis?
Annals of hepatology, , Volume: 15, Issue:3

Levels of malondialdehyde, myeloperoxidase and nitrotyrosine in patients with chronic viral hepatitis B and C.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, , Volume: 21, Issue:1

Reduced post-operative neutrophil activation in liver transplant recipients suffering from post-hepatitic cirrhosis.
Clinical transplantation, , Volume: 23, Issue:6

Impaired intracellular signaling, myeloperoxidase release and bactericidal activity of neutrophils from patients with alcoholic cirrhosis.
Journal of hepatology, , Volume: 64, Issue:5, 2016

Restoration of bactericidal activity of neutrophils by myeloperoxidase release: A new perspective for preventing infection in alcoholic cirrhosis.
Journal of hepatology, , Volume: 64, Issue:5, 2016

Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis.
Hepatology (Baltimore, Md.), , Volume: 50, Issue:5, 2009

Neutrophil and eosinophil involvement of the small bowel affected by chronic alcoholism.
Gut, , Volume: 29, Issue:12, 1988

Polymorph leucocyte function in uraemia and jaundice.
Acta haematologica, , Volume: 64, Issue:3, 1980

Erdosteine treatment attenuates oxidative stress and fibrosis in experimental biliary obstruction.
Pediatric surgery international, , Volume: 23, Issue:3, 2007

SLE and rapidly progressive glomerulonephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 45, Issue:5, 2005

Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss.
The Journal of pathology, , Volume: 205, Issue:4, 2005

Antineutrophil cytoplasmic autoantibody-associated rapidly progressive glomerulonephritis in a patient with primary biliary cirrhosis.
The American journal of the medical sciences, , Volume: 328, Issue:3, 2004

Myeloperoxidase-positive inflammatory cells participate in bile duct damage in primary biliary cirrhosis through nitric oxide-mediated reactions.
Hepatology (Baltimore, Md.), , Volume: 38, Issue:4, 2003

Goodpasture's syndrome associated with primary biliary cirrhosis.
Internal medicine (Tokyo, Japan), , Volume: 37, Issue:7, 1998

Ghrelin alleviates biliary obstruction-induced chronic hepatic injury in rats.
Regulatory peptides, , Feb-07, Volume: 146, Issue:1-3, 2008

Erdosteine treatment attenuates oxidative stress and fibrosis in experimental biliary obstruction.
Pediatric surgery international, , Volume: 23, Issue:3, 2007

Effect of hepatic iron concentration reduction on hepatic fibrosis and damage in rats with cholestatic liver disease.
World journal of gastroenterology, , Jan-14, Volume: 12, Issue:2, 2006

Long-term administration of aqueous garlic extract (AGE) alleviates liver fibrosis and oxidative damage induced by biliary obstruction in rats.
Life sciences, , Apr-15, Volume: 76, Issue:22, 2005

Intestinal mucosal oxidative damage and bacterial translocation in cirrhotic rats.
European journal of gastroenterology & hepatology, , Volume: 15, Issue:2, 2003

The effect of aminoguanidine against cholestatic liver injury in rats.
Cell biochemistry and function, , Volume: 25, Issue:6

Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 303, Issue:1, 2012

ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 280, Issue:6, 2001

Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Myeloperoxidase-Sensitive
ACS nano, , 02-28, Volume: 17, Issue:4, 2023

High Expression of MMP-9 in Primary Tumors and High Preoperative MPO in Serum Predict Improved Prognosis in Colorectal Cancer with Operable Liver Metastases.
Oncology, , Volume: 99, Issue:3, 2021

Serum Matrix Metalloproteinase-8 and Myeloperoxidase Predict Survival after Resection of Colorectal Liver Metastases.
Oncology, , Volume: 99, Issue:12, 2021

Neutrophil extracellular traps in patients with liver cirrhosis and hepatocellular carcinoma.
Scientific reports, , 09-09, Volume: 11, Issue:1, 2021

Co-Administration of iRGD with Sorafenib-Loaded Iron-Based Metal-Organic Framework as a Targeted Ferroptosis Agent for Liver Cancer Therapy.
International journal of nanomedicine, , Volume: 16, 2021

N-acetylcysteine alleviates liver injury by suppressing macrophage-mediated inflammatory response post microwave ablation.
International immunopharmacology, , Volume: 85, 2020

Nanozyme-assisted sensitive profiling of exosomal proteins for rapid cancer diagnosis.
Theranostics, , Volume: 10, Issue:20, 2020

Biomineralization Synthesis of the Cobalt Nanozyme in SP94-Ferritin Nanocages for Prognostic Diagnosis of Hepatocellular Carcinoma.
ACS applied materials & interfaces, , Mar-13, Volume: 11, Issue:10, 2019

Hepatoprotective effects of limb ischemic post-conditioning in hepatic ischemic rat model and liver cancer patients via PI3K/ERK pathways.
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Loss of SMAD4 from colorectal cancer cells promotes CCL15 expression to recruit CCR1+ myeloid cells and facilitate liver metastasis.
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A Calcium Fluoride Nanozyme for Ultrasound-Amplified and Ca
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[no title available]
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Is there a relationship between myeloperoxidase activity and conductive hearing loss in chronic otitis media complicated by cholesteatoma?
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Evaluation of oxidative stress and antioxidants effect on turning process acute otitis media to chronic otitis media with effusion.
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Levels of eosinophil cationic protein and myeloperoxidase from chronic middle ear effusion in patients with allergy and/or acute infection.
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A case of MPO-ANCA-positive polyarteritis nodosa complicated by exudative otitis media, mononeuritis multiplex, and acute renal failure.
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Levels of eosinophil cationic protein and myeloperoxidase from chronic middle ear effusion in patients with allergy and/or acute infection.
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Phagocytic activity and bactericidal capacity of polymorphonuclear leukocytes in children with recurrent otitis media.
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Differential clinicopathologic features of EGPA-associated neuropathy with and without ANCA.
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Rituximab prescription patterns and efficacy in the induction treatment of ANCA-Associated Vasculitis in a Belgian multicenter cohort.
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Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody-associated vasculitis.
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Myeloperoxidase-Antineutrophil Cytoplasmic Antibody (ANCA)-Positive Granulomatosis With Polyangiitis (Wegener's) Is a Clinically Distinct Subset of ANCA-Associated Vasculitis: A Retrospective Analysis of 315 Patients From a German Vasculitis Referral Cent
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Myeloperoxidase-Antineutrophil Cytoplasmic Antibody (ANCA)-Positive and ANCA-Negative Patients With Granulomatosis With Polyangiitis (Wegener's): Distinct Patient Subsets.
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N-acetylcysteine leads to greater ovarian protection than enoxaparin sodium in a rat ovarian torsion model.
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Binding of Intracellular Myeloperoxidase to αV/β1 Integrin Serves as a Mechanism of Survival in Epithelial Ovarian Cancer.
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Novel expression of CD11b in epithelial ovarian cancer: Potential therapeutic target.
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MPO density in primary cancer biopsies of ovarian carcinoma enhances the indicative value of IL-17 for chemosensitivity.
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Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress.
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[no title available]
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Recipient genetic determinants of inflammatory process and nonstandard atherosclerosis risk factors affect kidney graft function early posttransplantation.
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The effects of the Pringle maneuver on the pancreas: can octreotide be protective?
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Ischemic postconditioning modified renal oxidative stress and lipid peroxidation caused by ischemic reperfusion injury in rats.
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Tezosentan reduces the renal injury induced by abdominal aortic ischemia-reperfusion in rats.
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Priming donor lungs with thioredoxin-1 attenuates acute allograft injury in a rat model of lung transplantation.
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Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents.
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Pancreatic cellular injury after cardiac surgery with cardiopulmonary bypass: frequency, time course and risk factors.
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Effects of a membrane-permeable radical scavenger, Tempol, on healing of colonic anastomoses in the cecal ligation and puncture model of polymicrobial sepsis in rats.
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Induction of heme oxygenase-1 improves impaired intestinal transit after burn injury.
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A single intraperitoneal dose of carbon monoxide-saturated ringer's lactate solution ameliorates postoperative ileus in mice.
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Total liquid ventilation reduces lung injury in piglets after cardiopulmonary bypass.
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Surgical manipulation of the intestine and distant organ damage-protection by oral glutamine supplementation.
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The ICAM-1 antisense oligonucleotide ISIS-3082 prevents the development of postoperative ileus in mice.
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Inflammation of atrium after cardiac surgery is associated with inhomogeneity of atrial conduction and atrial fibrillation.
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The side-effects of cardiopulmonary bypass on the lungs: changes in bronchoalveolar lavage fluids.
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Reduced neutrophil infiltration protects against lung reperfusion injury after transplantation.
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Increased Neutrophil Activation and Plasma DNA Levels in Patients with Pre-Eclampsia.
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Neutrophil release of myeloperoxidase in systemic vasculature of obese women may put them at risk for preeclampsia.
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CD4+ T cells are important mediators of oxidative stress that cause hypertension in response to placental ischemia.
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Evaluation of the relationship between adenosine deaminase, myeloperoxidase, cholinesterase, preeclampsia severity, and neonatal outcomes.
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Myeloperoxidase in the plasma and placenta of normal pregnant women and women with pregnancies complicated by preeclampsia and intrauterine growth restriction.
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Oxidative damage, inflammation, and Toll-like receptor 4 pathway are increased in preeclamptic patients: a case-control study.
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Genetic variation of myeloperoxidase gene contributes to preeclampsia: a preliminary association study in Turkish population.
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A quantitative evaluation of total antioxidant status and oxidative stress markers in preeclampsia and gestational diabetic patients in 24-36 weeks of gestation.
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Serum advanced oxidation protein products, myeloperoxidase and ascorbic acid in pre-eclampsia and eclampsia.
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Oxidative stress-related gene polymorphism and the risk of preeclampsia.
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Pathological uterine perfusion in the second trimester is not associated with neutrophil activation.
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Increased systemic activation of neutrophils but not complement in preeclampsia.
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The use of platelet density and volume measurements to estimate the severity of pre-eclampsia.
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Association of the polymorphisms of MTHFR C677T, VDR C352T, and MPO G463A with risk for esophageal squamous cell dysplasia and carcinoma.
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Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides.
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A successful pregnancy and delivery case of Graves' disease with myeloperoxidase antineutrophil cytoplasmic antibody induced by propylthiouracil.
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Successful pregnancy and delivery of a healthy newborn despite transplacental transfer of antimyeloperoxidase antibodies from a mother with microscopic polyangiitis.
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Salmonella enterica serovar Enteritidis enterocolitis during late stages of gestation induces an adverse pregnancy outcome in the murine model.
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Infection and phagocytosis as possible mechanisms of rupture in premature rupture of the membranes.
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Cytochemical and ultrastructural studies of aberrant granules in the neutrophils of two patients with myeloperoxidase deficiency during a preleukemic state: relationship to abnormal bactericidal activity.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Maternal inflammation exacerbates neonatal hyperoxia-induced kidney injury in rat offspring.
Pediatric research, , Volume: 86, Issue:2, 2019

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Maternal and neonatal dietary intake of balanced n-6/n-3 fatty acids modulates experimental colitis in young adult rats.
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Comparative characteristics of the cytochemical status of peritoneal and alveolar macrophages in the progeny of female rats with experimental liver disease.
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Myeloperoxidase and Prostate volume: A preliminary study.
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Intriguing location of myeloperoxidase in the prostate: a preliminary immunohistochemical study.
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Prepubertal exposure to compounds that increase prolactin secretion in the male rat: effects on the adult prostate.
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A colorimetric paper sensor for citrate as biomarker for early stage detection of prostate cancer based on peroxidase-like activity of cysteine-capped gold nanoclusters.
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Proteomics-Metabolomics Combined Approach Identifies Peroxidasin as a Protector against Metabolic and Oxidative Stress in Prostate Cancer.
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[no title available]
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Evaluation of prognostic significance of granulocyte-related factors in cancer patients undergoing personalized peptide vaccination.
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Peroxidase-like activity of Fe3O4@carbon nanoparticles enhances ascorbic acid-induced oxidative stress and selective damage to PC-3 prostate cancer cells.
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[Association between the myeloperoxidase gene polymorphisms and the susceptibility to prostate cancer: a case-control study in a Chinese population].
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Manganese superoxide dismutase Ile58Thr, catalase C-262T and myeloperoxidase G-463A gene polymorphisms in patients with prostate cancer: relation to advanced and metastatic disease.
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Serum phospholipid fatty acids, genetic variation in myeloperoxidase, and prostate cancer risk in heavy smokers: a gene-nutrient interaction in the carotene and retinol efficacy trial.
American journal of epidemiology, , May-15, Volume: 177, Issue:10, 2013

Intriguing location of myeloperoxidase in the prostate: a preliminary immunohistochemical study.
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The association between polymorphisms in prooxidant or antioxidant enzymes (myeloperoxidase, SOD2, and CAT) and genes and prostate cancer risk in the Chinese population of Han nationality.
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Colorimetric platform for visual detection of cancer biomarker based on intrinsic peroxidase activity of graphene oxide.
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Genetic variation in myeloperoxidase modifies the association of serum α-tocopherol with aggressive prostate cancer among current smokers.
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Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer.
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[Case 8. Perspectives in 2007 for bladder pathology. Prostatic adenocarcinoma invading the bladder].
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Iron intake, oxidative stress-related genes (MnSOD and MPO) and prostate cancer risk in CARET cohort.
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Myeloperoxidase G-463A polymorphism and risk of lung and prostate cancer in a Turkish population.
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Anti-MPO small-vessel vasculitis causing prostatis and nephritis.
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Chronic prostatitis/chronic pelvic pain pyndrome): seminal markers of inflammation.
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Prepubertal exposure to compounds that increase prolactin secretion in the male rat: effects on the adult prostate.
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Maternal exposure to atrazine during lactation suppresses suckling-induced prolactin release and results in prostatitis in the adult offspring.
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The Role of Periostin in Capsule Formation on Silicone Implants.
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Crevicular fluid enzymes from endosseous dental implants and natural teeth.
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Protein- and zinc-deficient diets modulate the murine microbiome and metabolic phenotype.
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Increased Urinary Trimethylamine N-Oxide Following Cryptosporidium Infection and Protein Malnutrition Independent of Microbiome Effects.
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Assessment of myeloperoxidase and oxidative alpha1-antitrypsin in patients on hemodialysis.
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N-acetyl-L-glutamine, a liquid-stable source of glutamine, partially prevents changes in body weight and on intestinal immunity induced by protein energy malnutrition in pigs.
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Innate lung defenses and compromised Pseudomonas aeruginosa clearance in the malnourished mouse model of respiratory infections in cystic fibrosis.
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The effect of hypoprotein nutrition upon granular cationic proteins and myeloperoxidase and lactic dehydrogenase enzyme activities in rat peripheral blood granulocytes. Study I.
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Myeloperoxidase-enhanced formation of (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene-DNA adducts in lung tissue in vitro: a role of pulmonary inflammation in the bioactivation of a procarcinogen.
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Promyelocytic Differentiation in Infiltrates of Prurigo Pigmentosa: An Analogy to Histiocytoid Sweet Syndrome.
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Mild generalised pustular psoriasis patient with a heterozygous hypomorphic MPO variant successfully treated with granulocyte and monocyte adsorption apheresis.
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Myeloperoxidase and its negative relationship with cholesterol efflux capacity in patients with psoriasis: results from an observational cohort study.
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Transcriptomes of MPO-Deficient Patients with Generalized Pustular Psoriasis Reveals Expansion of CD4
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Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways.
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Genetic Analysis of MPO Variants in Four Psoriasis Subtypes in Patients from Germany.
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Cannabidiol Modifies the Formation of NETs in Neutrophils of Psoriatic Patients.
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Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases.
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Loss-of-Function Myeloperoxidase Mutations Are Associated with Increased Neutrophil Counts and Pustular Skin Disease.
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Therapeutic treatment with Ibrutinib attenuates imiquimod-induced psoriasis-like inflammation in mice through downregulation of oxidative and inflammatory mediators in neutrophils and dendritic cells.
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Differentiating Psoriatic Arthritis From Psoriasis Without Psoriatic Arthritis Using Novel Serum Biomarkers.
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Serum markers for asymptomatic atherosclerosis in Egyptian psoriatic patients: study controlled by Doppler estimation of carotid intima-media thickness.
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Psoriatic inflammation causes hepatic inflammation with concomitant dysregulation in hepatic metabolism via IL-17A/IL-17 receptor signaling in a murine model.
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A novel approach in psoriasis: first usage of known protein oxidation markers to prove oxidative stress.
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Topical atorvastatin ameliorates 12-O-tetradecanoylphorbol-13-acetate induced skin inflammation by reducing cutaneous cytokine levels and NF-κB activation.
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Polyandric acid A, a clerodane diterpenoid from the Australian medicinal plant Dodonaea polyandra, attenuates pro-inflammatory cytokine secretion in vitro and in vivo.
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Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis.
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Function of granulocytes with deficient myeloperoxidase-mediated iodination in a patient with generalized pustular psoriasis.
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Neutrophil function and energy status in Holstein cows with uterine health disorders.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
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Severe Pulmonary Embolism, Thrombosis of Lower Extremity, Unexpected Mild Renal Disorder in MPO-ANCA Associated Vasculitis: A Case Report.
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Association of Pulmonary Hemorrhage, Positive Proteinase 3, and Urinary Red Blood Cell Casts With Venous Thromboembolism in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
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Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice.
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Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice.
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Opposing effects of emphysema, hay fever, and select genetic variants on lung cancer risk.
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Search for drugs that may reduce the load of neutrophil azurophilic granule enzymes in the lungs of patients with emphysema.
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Evaluation of gelatinases, tissue inhibitor of matrix metalloproteinase-2, and myeloperoxidase protein in healthy and inflamed human dental pulp tissue.
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Torasemide-induced Vascular Purpura in the Course of Eosinophilic Granulomatosis with Polyangiitis.
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Cryoglobulins and multispecific antineutrophil cytoplasmic antibodies in propylthiouracil-induced necrotizing cutaneous vasculitis--a new association.
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Crescentic glomerulonephritis with positive antineutrophil cytoplasmic autoantibody specific for myeloperoxidase associated with autoimmune hemolytic anemia and thrombocytopenic purpura.
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Thrombotic thrombocytopenic purpura in a patient with rapidly progressive glomerulonephritis with both anti-glomerular basement membrane antibodies and myeloperoxidase anti-neutrophil cytoplasmic antibodies.
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Exploring the Therapeutic Efficacy of Zingerone Nanoparticles in Treating Biofilm-Associated Pyelonephritis Caused by Pseudomonas aeruginosa in the Murine Model.
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Serum levels of the soluble haemoglobin scavenger receptor CD163 in MPO-ANCA-associated renal vasculitis.
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Protective effect of mitochondria-targeted antioxidants in an acute bacterial infection.
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Role of complement-derived and bacterial formylpeptide chemotactic factors in the in vivo migration of neutrophils in experimental Escherichia coli pyelonephritis in rats.
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Failure of dexamethasone to prevent polymorphonuclear leukocyte infiltration during experimental acute exudative pyelonephritis and to reduce subsequent chronic scarring.
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Nanoencapsulation of coenzyme Q10 and vitamin E acetate protects against UVB radiation-induced skin injury in mice.
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The relationship between the severity of radiation-induced oral mucositis and the myeloperoxidase levels in rats.
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Protection by L-carnitine against radiation-induced ileal mucosal injury in the rat: pattern of oxidative stress, apoptosis and cytokines.
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Enalapril mitigates focal alveolar lesions, a histological marker of late pulmonary injury by radiation to the lung.
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Inhibition of ultraviolet light B-induced cutaneous inflammation by a specific cyclooxygenase-2 inhibitor.
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Characterization of the acute inflammatory response after irradiation in mice and its regulation by interleukin 4 (Il4).
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Neutrophil Accumulation in the Small Intestine Contributes to Local Tissue Destruction Following Combined Radiation and Burn Injury.
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Microwave treatment of eight seconds protects cells of Isatis indigotica from enhanced UV-B radiation lesions.
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Granulocytes' enzymes as biomarkers of radiotoxicity in individuals occupationally exposed to low-level radiation.
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Prdx6 is required to protect human corneal epithelial cells against ultraviolet B injury.
European journal of ophthalmology, , Volume: 31, Issue:2, 2021

A novel model of megavoltage radiation-induced oral mucositis in hamsters: Role of inflammatory cytokines and nitric oxide.
International journal of radiation biology, , Volume: 91, Issue:6, 2015

Evaluation of edaravone against radiation-induced oral mucositis in mice.
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Inhibition of protease-activated receptor 1 ameliorates intestinal radiation mucositis in a preclinical rat model.
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Validation of a surgical technique for rat intestinal irradiation: potential side effects prevention by dietary grape phenolics.
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The effect of magnesium and vitamin E pre-treatments on irradiation-induced oxidative injury of cardiac and pulmonary tissues in rats: a randomized experimental study.
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Rho kinase signalling mediates radiation-induced inflammation and intestinal barrier dysfunction.
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Preventive effect of pentoxifylline on acute radiation damage via antioxidant and anti-inflammatory pathways.
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Resveratrol protects against irradiation-induced hepatic and ileal damage via its anti-oxidative activity.
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The effect of N-acetylcysteine on biomarkers for radiation-induced oxidative damage in a rat model.
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The effect of heme oxygenase-1 induction by glutamine on radiation-induced intestinal damage: the effect of heme oxygenase-1 on radiation enteritis.
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The efficacy of octreotide in pancreatic and intestinal changes: radiation-induced enteritis in animals.
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The effect of heme oxygenase-1 induction by octreotide on radiation enteritis.
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Increased expression of cyclooxygenase-2 (COX-2) in radiation-induced small bowel injury in rats.
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The effect of glutamine on radiation-induced organ damage.
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Radiation enteropathy and leucocyte-endothelial cell reactions in a refined small bowel model.
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'In-field' and 'out-of-field' functional impairment during subacute and chronic phases of experimental radiation enteropathy in the rat.
International journal of radiation biology, , Volume: 79, Issue:6, 2003

Radiation-induced acute intestinal inflammation differs following total-body versus abdominopelvic irradiation in the ferret.
International journal of radiation biology, , Volume: 77, Issue:3, 2001

Intestinal and colonic motor alterations associated with irradiation-induced diarrhoea in rats.
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Absence of protective role of afferent nerves in early intestinal mucosal alterations induced by abdominal irradiation in rats.
International journal of radiation biology, , Volume: 77, Issue:3, 2001

Expression of ICAM-1 and acute inflammatory cell infiltration in the early phase of radiation colitis in rats.
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The synthetic somatostatin analogue, octreotide, ameliorates acute and delayed intestinal radiation injury.
International journal of radiation oncology, biology, physics, , Dec-01, Volume: 45, Issue:5, 1999

Inhibitory effects of pentoxifylline on ultraviolet B light-induced cutaneous inflammation.
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Human ghrelin ameliorates organ injury and improves survival after radiation injury combined with severe sepsis.
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l-Theanine and NEP1-40 promote nerve regeneration and functional recovery after brachial plexus root avulsion.
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Topical application of Nexrutine inhibits ultraviolet B-induced cutaneous inflammatory responses in SKH-1 hairless mouse.
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Autoantibodies to myeloperoxidase in systemic sclerosis.
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The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitis.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

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The Proton-activated Receptor GPR4 Modulates Intestinal Inflammation.
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Development and evaluation of a new ELISA for the detection and quantification of antierythropoietin antibodies in human sera.
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Acute and chronic nociceptive phases observed in a rat hind paw ischemia/reperfusion model depend on different mechanisms.
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Neurogenic inflammation in an animal model of neuropathic pain.
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Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.
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Resolution of anti-neutrophil cytoplasmic antibody-associated vasculitis after resection of gastric cancer.
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Potential etiologic agents in sarcoidosis.
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Peripheral blood neutrophils in children in remission of acute lymphoblastic leukaemia. Cytochemical investigations.
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Pauci-immune extracapillary glomerulonephritis and atheromatous embolization.
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Identification of intracellular markers in induced sputum and bronchoalveolar lavage samples in patients with respiratory disorders and healthy persons.
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Surfactant Components and Tracheal Aspirate Inflammatory Markers in Preterm Infants with Respiratory Distress Syndrome.
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Umbilical cord serum interleukin-6, C-reactive protein, and myeloperoxidase concentrations at birth and association with neonatal morbidities and long-term neurodevelopmental outcomes.
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Role of macrophages in bile acid-induced inflammatory response of fetal lung during maternal cholestasis.
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Effects of hyaluronan-fortified surfactant in ventilated premature piglets with respiratory distress.
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3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants: association with adverse respiratory outcome.
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Bronchoalveolar oxyradical inflammatory elements herald bronchopulmonary dysplasia.
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Closure of patent ductus arteriosus decreases pulmonary myeloperoxidase in premature infants with respiratory distress syndrome.
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Effect of controlled human exposure to diesel exhaust and allergen on airway surfactant protein D, myeloperoxidase and club (Clara) cell secretory protein 16.
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Synthesis, Pharmacological Profile and Docking Studies of New Sulfonamides Designed as Phosphodiesterase-4 Inhibitors.
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Investigation of the protective effects of proanthocyanidin and vitamin E against the toxic effect caused by formaldehyde on the liver tissue.
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The putative role of ovary removal and progesterone when considering the effect of formaldehyde exposure on lung inflammation induced by ovalbumin.
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Effects of exposure to nanoparticle-rich or -depleted diesel exhaust on allergic pathophysiology in the murine lung.
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Resolution of the oedema associated with allergic pulmonary inflammation in rats assessed noninvasively by magnetic resonance imaging.
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Pulmonary edema induced by allergen challenge in the rat: noninvasive assessment by magnetic resonance imaging.
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Influence of personal factors on nasal patency and lavage biomarkers in white-collar workers.
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Concentrations of myeloperoxidase in nasal secretions of atopic patients after nasal allergen challenge and during natural allergen exposure.
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Quantitation of eosinophil and neutrophil infiltration into rat lung by specific assays for eosinophil peroxidase and myeloperoxidase. Application in a Brown Norway rat model of allergic pulmonary inflammation.
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Nasal challenge shows pathogenetic relevance of specific IgE serum antibodies for nasal symptoms caused by hexahydrophthalic anhydride.
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Prognosis of pulmonary fibrosis presenting with a usual interstitial pneumonia pattern on computed tomography in patients with myeloperoxidase anti-neutrophil cytoplasmic antibody-related nephritis: a retrospective single-center study.
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A 27-year-old woman presenting with refractory hypoxaemic respiratory failure, haemoptysis and thyrotoxicosis: a rare manifestation of propylthiouracil therapy.
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Circulating histones are mediators of trauma-associated lung injury.
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Dexamethasone therapy in preterm infants developing bronchopulmonary dysplasia: effect on pulmonary surfactant disaturated-phosphatidylcholine kinetics.
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Disseminated extramedullary myeloid tumor of the gallbladder without involvement of the bone marrow.
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[Case of myeloperoxidase-antineutrophil cytoplasmic antibody-associated pulmonary alveolar hemorrhage caused by propylthiouracil].
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Mixed connective tissue disease associated with MPO-ANCA-positive polyangiitis.
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The influence of iloprost on acute lung injury induced by hind limb ischemia-reperfusion in rats.
Pulmonary pharmacology & therapeutics, , Volume: 18, Issue:4, 2005

Different effects of surfactant and inhaled nitric oxide in modulation of inflammatory injury in ventilated piglet lungs.
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Sivelestat, a specific neutrophil elastase inhibitor, prevented phorbol myristate acetate-induced acute lung injury in conscious rabbits.
Pulmonary pharmacology & therapeutics, , Volume: 18, Issue:4, 2005

Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters.
European journal of pharmacology, , Mar-19, Volume: 488, Issue:1-3, 2004

Serum ECP and MPO are increased during exacerbations of chronic bronchitis with airway obstruction.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 54, Issue:5, 2000

Effect of sodium azide on hydrogen peroxide production by zymosan-activated human neutrophils.
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Prospective evaluation of thoracic-duct drainage in the treatment of respiratory failure complicating severe acute pancreatitis.
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Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Science & sports, , Apr-04, 2023

Case 32-2017. A 64-Year-Old Man with Dyspnea, Wheezing, Headache, Cough, and Night Sweats.
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Neutrophil infiltration and activation in bronchiolitic airways are independent of viral etiology.
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The association between paracetamol and asthma is still under debate.
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Serum myeloperoxidase in wheezing infants: no association with later asthma.
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Effects of montelukast treatment on clinical and inflammatory variables in patients with cystic fibrosis.
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Markers of airway inflammation in preschool wheezers.
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Tidal flow volume loops and inflammatory indicators in small children.
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Promising Neutrophil-Associated Biomarkers in Lung Diseases of Patients with Antisynthetase Syndrome and Dermatomyositis.
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Peroxidasin contributes to lung host defense by direct binding and killing of gram-negative bacteria.
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Clinical trial for Japanese patients with myeloperoxidase anti-neutrophil cytoplasmic antibody-associated vasculitis: the JMAAV study.
Clinical and experimental nephrology, , Volume: 17, Issue:5, 2013

Flagellin administration protects respiratory tract from Burkholderia cepacia infection.
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Immunological and pathological aspects of respiratory tract infection with Stenotrophomonas maltophilia in BALB/c mice.
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Identifying peroxidases and their oxidants in the early pathology of cystic fibrosis.
Free radical biology & medicine, , Nov-15, Volume: 49, Issue:9, 2010

Quercetin reduces illness but not immune perturbations after intensive exercise.
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The TG system for bedside recording of sputum colour.
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Randomized, double-blind, placebo-controlled, dose-escalating study of aerosolized interferon gamma-1b in patients with mild to moderate cystic fibrosis lung disease.
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Effect of leukotoxin of Mannheimia haemolytica and LPS of E. coli on secretory response of bovine neutrophils in vitro.
Polish journal of veterinary sciences, , Volume: 8, Issue:2, 2005

Assessment of neutrophil components as markers of lung injury in the course of bovine respiratory tract infections.
Polish journal of veterinary sciences, , Volume: 7, Issue:3, 2004

Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections.
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Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease.
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Innate lung defenses and compromised Pseudomonas aeruginosa clearance in the malnourished mouse model of respiratory infections in cystic fibrosis.
Infection and immunity, , Volume: 68, Issue:4, 2000

Evidence for excessive bronchial inflammation during an acute exacerbation of chronic obstructive pulmonary disease in patients with alpha(1)-antitrypsin deficiency (PiZ).
American journal of respiratory and critical care medicine, , Volume: 160, Issue:6, 1999

Assessment of serum myeloperoxidase in children with bronchial asthma.
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Role of nasal interleukin-8 in neutrophil recruitment and activation in children with virus-induced asthma.
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Neutrophil mediators, Pseudomonas, and pulmonary dysfunction in cystic fibrosis.
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Lipoprotein-associated phospholipase A2, myeloperoxidase and vascular endothelial growth factor - predictors of high vascular risk in respiratory bacterial infections.
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The association between circulating neutrophil extracellular trap related biomarkers and retinal vein occlusion incidence: A case-control pilot study.
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Eye manifestations in patients with perinuclear antineutrophil cytoplasmic antibody-associated vasculitis: case series and literature review.
Japanese journal of ophthalmology, , Volume: 51, Issue:2

Effects of a new dexamethasone-delivery system (Surodex) on experimental intraocular inflammation models.
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Local effects of different perfluorochemical agents.
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Essential role of CCR2 in neutrophil tissue infiltration and multiple organ dysfunction in sepsis.
American journal of respiratory and critical care medicine, , Jan-15, Volume: 183, Issue:2, 2011

Betulinic acid inhibits endotoxin-stimulated phosphorylation cascade and pro-inflammatory prostaglandin E(2) production in human peripheral blood mononuclear cells.
British journal of pharmacology, , Volume: 162, Issue:6, 2011

Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis.
Journal of critical care, , Volume: 26, Issue:4, 2011

Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation.
Free radical biology & medicine, , May-15, Volume: 48, Issue:10, 2010

Treatment with histone deacetylase inhibitor attenuates MAP kinase mediated liver injury in a lethal model of septic shock.
The Journal of surgical research, , Volume: 163, Issue:1, 2010

Preconditioning with ozone/oxygen mixture induces reversion of some indicators of oxidative stress and prevents organic damage in rats with fecal peritonitis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 58, Issue:7, 2009

Paeoniflorin inhibits systemic inflammation and improves survival in experimental sepsis.
Basic & clinical pharmacology & toxicology, , Volume: 105, Issue:1, 2009

Protective effect of suberoylanilide hydroxamic acid against LPS-induced septic shock in rodents.
Shock (Augusta, Ga.), , Volume: 32, Issue:5, 2009

[The role of hydrogen sulfide in acute lung injury during endotoxic shock and its relationship with nitric oxide and carbon monoxide].
Zhonghua yi xue za zhi, , Aug-19, Volume: 88, Issue:32, 2008

Tezosentan attenuates organ injury and mesenteric blood flow decrease in endotoxemia and cecal ligation and puncture.
The Journal of surgical research, , Volume: 141, Issue:2, 2007

[Effects of normal lymph on myeloperoxidase activity and adenosine triphosphatase in rats with endotoxic shock].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, , Volume: 18, Issue:12, 2006

Urocortin and adrenomedullin prevent lethal endotoxemia by down-regulating the inflammatory response.
The American journal of pathology, , Volume: 168, Issue:6, 2006

15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock.
Shock (Augusta, Ga.), , Volume: 24, Issue:1, 2005

Protective role of angiopoietin-1 in endotoxic shock.
Circulation, , Jan-04, Volume: 111, Issue:1, 2005

p53 is a suppressor of inflammatory response in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 19, Issue:8, 2005

Analysis of the role of the PAC1 receptor in neutrophil recruitment, acute-phase response, and nitric oxide production in septic shock.
Journal of leukocyte biology, , Volume: 77, Issue:5, 2005

Treatment with a novel poly(ADP-ribose) glycohydrolase inhibitor reduces development of septic shock-like syndrome induced by zymosan in mice.
Critical care medicine, , Volume: 32, Issue:6, 2004

A potential role of hyperbaric oxygen exposure through intestinal nuclear factor-kappaB.
Critical care medicine, , Volume: 32, Issue:8, 2004

Comparative study of glucocorticoids, cyclosporine A, and JTE-607 [(-)-Ethyl-N[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]-L-phenylalaninate dihydrochloride] in a mouse septic shock model.
The Journal of pharmacology and experimental therapeutics, , Volume: 311, Issue:3, 2004

Cardiac UCP2 expression and myocardial oxidative metabolism during acute septic shock in the rat.
Shock (Augusta, Ga.), , Volume: 19, Issue:6, 2003

Therapeutic effect of propofol in the treatment of endotoxin-induced shock in rats.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, , Volume: 23, Issue:3, 2003

Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-kappaB and MAPK/ERK mechanisms.
American journal of physiology. Lung cellular and molecular physiology, , Volume: 283, Issue:4, 2002

Inosine improves gut permeability and vascular reactivity in endotoxic shock.
Critical care medicine, , Volume: 29, Issue:4, 2001

DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin.
Free radical research, , Volume: 35, Issue:6, 2001

Resistance to endotoxin shock in transgenic mice overexpressing endothelial nitric oxide synthase.
Circulation, , Feb-29, Volume: 101, Issue:8, 2000

Pyrrolidine dithiocarbamate prevents I-kappaB degradation and reduces microvascular injury induced by lipopolysaccharide in multiple organs.
Molecular pharmacology, , Volume: 55, Issue:4, 1999

Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection.
American journal of respiratory and critical care medicine, , Volume: 157, Issue:3 Pt 1, 1998

Poly (ADP-ribose) synthetase activation mediates pulmonary microvascular and intestinal mucosal dysfunction in endotoxin shock.
Life sciences, , Volume: 63, Issue:23, 1998

Effect of rebamipide on liver damage and increased tumor necrosis factor in a rat model of endotoxin shock.
Digestive diseases and sciences, , Volume: 43, Issue:9 Suppl, 1998

Protective effect of ciliary neurotrophic factor (CNTF) in a model of endotoxic shock: action mechanisms and role of CNTF receptor alpha.
Journal of inflammation, , Volume: 48, Issue:2, 1998

Attenuation of endotoxin-induced pathophysiology by a new potent PAF receptor antagonist.
Shock (Augusta, Ga.), , Volume: 5, Issue:4, 1996

[A case of fluminant septic shock due to Streptococcus agalactiae in a patient with MPO-ANCA related glomerulonephritis].
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, , Volume: 70, Issue:11, 1996

Beneficial cardiopulmonary effects of pentoxifylline in experimental sepsis are lost once septic shock is established.
Archives of surgery (Chicago, Ill. : 1960), , Volume: 129, Issue:11, 1994

Monophosphoryl lipid A protects against endotoxic shock via inhibiting neutrophil infiltration and preventing disseminated intravascular coagulation.
Circulatory shock, , Volume: 43, Issue:3, 1994

Effect of granulocyte colony-stimulating factor on systemic and pulmonary responses to endotoxin in pigs.
The Journal of trauma, , Volume: 34, Issue:4, 1993

A novel leukotriene B4-receptor antagonist in endotoxin shock: a prospective, controlled trial in a porcine model.
Critical care medicine, , Volume: 21, Issue:12, 1993

Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia.
Journal of immunology (Baltimore, Md. : 1950), , May-01, Volume: 148, Issue:9, 1992

Persistent bactericidal defect in neutrophils from a young woman who recovered from toxic shock syndrome.
Inflammation, , Volume: 10, Issue:4, 1986

Protective effects of BAY U 3405, a thromboxane A2 receptor antagonist, in endotoxin shock.
Pharmacological research, , Volume: 30, Issue:2

Inhibition of systemic inflammation by central action of the neuropeptide alpha-melanocyte- stimulating hormone.
Neuroimmunomodulation, , Volume: 6, Issue:3

Effect of remote ischemic conditioning on the immune-inflammatory profile in patients with traumatic hemorrhagic shock in a randomized controlled trial.
Scientific reports, , 04-29, Volume: 13, Issue:1, 2023

Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion.
Molecules (Basel, Switzerland), , Dec-20, Volume: 21, Issue:12, 2016

Comparisons of three surgical procedures on intestine ischemia reperfusion injury in a superior mesenteric artery injury model.
The Journal of surgical research, , Jun-01, Volume: 168, Issue:1, 2011

Effect of the combination of fibrin glue and growth hormone on intestinal anastomoses in a pig model of traumatic shock associated with peritonitis.
World journal of surgery, , Volume: 33, Issue:3, 2009

[Protective effects of ulinastatin on ischemia/reperfusion injury in the rabbit lung in traumatic hemorrhagic shock].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, , Volume: 17, Issue:1, 2005

[Effects of escharectomy during shock stage on tissue high mobility group box-1 expression and balance of pro-/anti-inflammatory response in rats after severe thermal injury].
Zhonghua wai ke za zhi [Chinese journal of surgery], , Jul-22, Volume: 42, Issue:14, 2004

Vascular endothelial growth factor attenuates trauma-induced injury in rats.
British journal of pharmacology, , Volume: 129, Issue:1, 2000

[The effect of escharectomy during burn shock stage on the expression of ICAM-1 and TNF-alpha mRNA of rat pulmonary tissue].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns, , Volume: 16, Issue:1, 2000

L-arginine attenuates endothelial dysfunction and prolongs survival in rats subjected to traumatic shock.
Endothelium : journal of endothelial cell research, , Volume: 6, Issue:1, 1998

Cellular mechanisms of heparinase III protection in rat traumatic shock.
The American journal of physiology, , Volume: 275, Issue:1, 1998

Beneficial effects of C1 esterase inhibitor in murine traumatic shock.
Shock (Augusta, Ga.), , Volume: 8, Issue:3, 1997

Time course of endothelial dysfunction and neutrophil adherence and infiltration during murine traumatic shock.
Shock (Augusta, Ga.), , Volume: 6, Issue:3, 1996

Beneficial effects of LEX032, a novel recombinant serine protease inhibitor, in murine traumatic shock.
Shock (Augusta, Ga.), , Volume: 4, Issue:4, 1995

Beneficial effects of oligotide, a novel oligodeoxyribonucleotide, in murine traumatic shock.
Shock (Augusta, Ga.), , Volume: 3, Issue:1, 1995

Beneficial actions of CP-0127, a novel bradykinin receptor antagonist, in murine traumatic shock.
The American journal of physiology, , Volume: 266, Issue:3 Pt 2, 1994

Sialyl Lewisx-containing oligosaccharide exerts beneficial effects in murine traumatic shock.
The American journal of physiology, , Volume: 267, Issue:6 Pt 2, 1994

Administration of polymerized bovine hemoglobin improves survival in a rat model of traumatic shock.
Methods and findings in experimental and clinical pharmacology, , Volume: 21, Issue:6

[Effect of hemosorption on biochemical and hematological indices of the blood in traumatic toxicosis].
Patologicheskaia fiziologiia i eksperimental'naia terapiia, , Issue:3

Effects of recombinant bactericidal, permeability-increasing protein on bacterial translocation and pulmonary neutrophil sequestration in burned mice.
The Journal of burn care & rehabilitation, , Volume: 18, Issue:1 Pt 1

Involvement of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-8, and interleukin-1 receptor antagonist in acute lung injury caused by local Shwartzman reaction.
Pathology international, , Volume: 47, Issue:1, 1997

Acute salivary gland hypofunction in the duct ligation model in the absence of inflammation.
Oral diseases, , Volume: 14, Issue:6, 2008

Experimental models of acute and chronic sialoadenitis in the guinea pig.
Japanese journal of pharmacology, , Volume: 59, Issue:3, 1992

Increased in vivo activation of neutrophils and complement in sickle cell disease.
The American journal of tropical medicine and hygiene, , Volume: 49, Issue:6, 1993

Pedigree analysis and involvement of peroxidase in sickle cell disease.
JPMA. The Journal of the Pakistan Medical Association, , Volume: 42, Issue:8, 1992

Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Preceded by Temporal Arteritis and Sjögren Syndrome.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, , Dec-01, Volume: 27, Issue:8S, 2021

Can antineutrophil cytoplasmic antibody positivity at diagnosis predict the poor outcomes of Sjögren's syndrome?
Rheumatology international, , Volume: 40, Issue:7, 2020

Emergence of Smoldering ANCA-associated Glomerulonephritis during the Clinical Course of Mixed Connective Tissue Disease and Sjögren's Syndrome.
Internal medicine (Tokyo, Japan), , Jun-15, Volume: 57, Issue:12, 2018

Dual anti-neutrophil cytoplasmic antibody-related pauci-immune crescentic glomerulonephritis in a patient with Sjögren's syndrome.
Rheumatology international, , Volume: 36, Issue:9, 2016

Pulmonary hyalinizing granuloma associated with Sjögren syndrome and ANCA MPO vasculitis.
Joint bone spine, , Volume: 82, Issue:1, 2015

Salivary: flow and proteins of the innate and adaptive immunity in the limited and diffused systemic sclerosis.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, , Volume: 43, Issue:7, 2014

Increased levels of serum myeloperoxidase in patients with active rheumatoid arthritis.
Life sciences, , Nov-04, Volume: 117, Issue:1, 2014

Sjøgren's syndrome-associated oxidative stress and mitochondrial dysfunction: prospects for chemoprevention trials.
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Medicina clinica, , Nov-17, Volume: 139, Issue:12, 2012

Sjögren's syndrome with ANCA-associated crescentic extramembranous glomerulonephritis.
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Cow's milk protein sensitivity assessed by the mucosal patch technique is related to irritable bowel syndrome in patients with primary Sjögren's syndrome.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 38, Issue:6, 2008

Mixed connective tissue disease associated with MPO-ANCA-positive polyangiitis.
Internal medicine (Tokyo, Japan), , Volume: 45, Issue:20, 2006

Pulmonary fibrosis in myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitides.
Respirology (Carlton, Vic.), , Volume: 9, Issue:2, 2004

Development and evaluation of a new ELISA for the detection and quantification of antierythropoietin antibodies in human sera.
Journal of immunological methods, , Volume: 294, Issue:1-2, 2004

Autoimmune thyroiditis and anti-thyroid antibodies in primary Sjogren's syndrome: a case-control study.
Annals of the rheumatic diseases, , Volume: 63, Issue:5, 2004

Impaired neurotransmission in lacrimal and salivary glands of a murine model of Sjögren's syndrome.
Advances in experimental medicine and biology, , Volume: 506, Issue:Pt B, 2002

Impaired neurotransmitter release from lacrimal and salivary gland nerves of a murine model of Sjögren's syndrome.
Investigative ophthalmology & visual science, , Volume: 42, Issue:5, 2001

Antineutrophil cytoplasmic antibody in patients with primary Sjögren's syndrome.
Clinical rheumatology, , Volume: 18, Issue:3, 1999

Tear fluid analysis in primary Sjögren's syndrome.
Clinical and experimental rheumatology, , Volume: 11, Issue:2

Enhanced neutrophil and eosinophil adhesion in patients with primary Sjögren's syndrome.
Clinical and experimental rheumatology, , Volume: 16, Issue:3

Polymorphism in the TNF-alpha gene promoter at position -1031 is associated with increased circulating levels of TNF-alpha, myeloperoxidase and nitrotyrosine in primary Sjögren's syndrome.
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Exploratory classification of clinical phenotypes in Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis using cluster analysis.
Scientific reports, , 03-04, Volume: 11, Issue:1, 2021

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Phenotypical and Functional Characterization of Neutrophils in Two Pyrin-Associated Auto-inflammatory Diseases.
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Loss-of-Function Myeloperoxidase Mutations Are Associated with Increased Neutrophil Counts and Pustular Skin Disease.
American journal of human genetics, , 09-03, Volume: 107, Issue:3, 2020

Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases.
American journal of human genetics, , 09-03, Volume: 107, Issue:3, 2020

The complexity of classifying ANCA-associated small-vessel vasculitis in actual clinical practice: data from a multicenter retrospective survey.
Rheumatology international, , Volume: 40, Issue:2, 2020

Investigating the histopathological findings and immunolocalization of rickettsialpox infection in skin biopsies: A case series and review of the literature.
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VISUAL VIGNETTE.
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Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody-associated vasculitis.
Rheumatology (Oxford, England), , 11-01, Volume: 56, Issue:11, 2017

Fever, lipodystrophy and cutaneous lesions.
Clinical and experimental dermatology, , Volume: 42, Issue:8, 2017

Anti-TWEAK monoclonal antibodies reduce vascular damage and leucocyte infiltration in a mouse model of cutaneous reverse passive Arthus reaction.
Clinical and experimental dermatology, , Volume: 41, Issue:8, 2016

Histologic and Immunohistochemical Features of the Skin Lesions in CANDLE Syndrome.
The American Journal of dermatopathology, , Volume: 37, Issue:7, 2015

Topical application of the adenosine A2A receptor agonist CGS-21680 prevents phorbol-induced epidermal hyperplasia and inflammation in mice.
Experimental dermatology, , Volume: 23, Issue:8, 2014

Topical anti-inflammatory activity of a monofloral honey of Mimosa scabrella provided by Melipona marginata during winter in southern Brazil.
Journal of medicinal food, , Volume: 17, Issue:7, 2014

The microalga Spirulina platensis presents anti-inflammatory action as well as hypoglycemic and hypolipidemic properties in diabetic rats.
Journal of complementary & integrative medicine, , Aug-10, Volume: 9, 2012

Garcinia gardneriana (Planchon & Triana) Zappi. (Clusiaceae) as a topical anti-inflammatory alternative for cutaneous inflammation.
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Evaluation of the serum catalase and myeloperoxidase activities in chronic arsenic-exposed individuals and concomitant cytogenetic damage.
Toxicology and applied pharmacology, , Nov-15, Volume: 249, Issue:1, 2010

Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes.
Toxicology, , Mar-29, Volume: 257, Issue:3, 2009

Topical anti-inflammatory activity of Serjania erecta Radlk (Sapindaceae) extracts.
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The histiocytic component of cutaneous manifestations of Kikuchi disease expresses myeloperoxidase.
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Clinical and histopathologic features of 8 patients with microscopic polyangiitis including two with a slowly progressive clinical course.
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Inhibition of ultraviolet light B-induced cutaneous inflammation by a specific cyclooxygenase-2 inhibitor.
Advances in experimental medicine and biology, , Volume: 507, 2002

Beta2-microglobulin-deficient mice are resistant to bullous pemphigoid.
The Journal of experimental medicine, , Aug-29, Volume: 186, Issue:5, 1997

Microscopic polyangiitis. Delineation of a cutaneous-limited variant associated with antimyeloperoxidase autoantibody.
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Ciba Foundation symposium, , Volume: 192, 1995

Genetic immunodeficiencies: cutaneous manifestations and recent progress.
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Leflunomide: an active antiinflammatory and antiproliferative agent in models of dermatologic disease.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 44 Suppl 2, 1995

Parallel tubular granules in human immature neutrophils--an electron microscopic study.
Leukemia & lymphoma, , Volume: 15, Issue:1-2, 1994

Microscopic polyarteritis. Report of a case with cutaneous involvement and antimyeloperoxidase antibodies.
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Mild generalised pustular psoriasis patient with a heterozygous hypomorphic MPO variant successfully treated with granulocyte and monocyte adsorption apheresis.
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Transcriptomes of MPO-Deficient Patients with Generalized Pustular Psoriasis Reveals Expansion of CD4
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Bryostatin 1 causes attenuation of TPA‑mediated tumor promotion in mouse skin.
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Immunophenotypic analysis of myeloperoxidase-negative leukemia cutis and blastic plasmacytoid dendritic cell neoplasm.
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Utility of myeloperoxidase stain in the differential diagnosis of leukemia cutis vs. hystiocitoid Sweet syndrome.
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An updated approach to the diagnosis of myeloid leukemia cutis.
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Topically applied vitamin E prevents massive cutaneous inflammatory and oxidative stress responses induced by double application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in mice.
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Inhibition of TPA-induced tumor promotion in CD-1 mouse epidermis by a polyphenolic fraction from grape seeds.
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Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1alpha expression in SENCAR mouse epidermis: implica
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Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice.
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Inhibition of tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by crocetin.
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7,12-dimethylbenz[a]anthracene induces oxidative DNA modification in vivo.
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[no title available]
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Inhibition of the dephosphorylation of eukaryotic initiation factor 2α ameliorates murine experimental colitis.
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Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis.
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Green tea and vitamin E enhance exercise-induced benefits in body composition, glucose homeostasis, and antioxidant status in elderly men and women.
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Protective effect of myricetin in dextran sulphate sodium-induced murine ulcerative colitis.
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Formylated peptides are important virulence factors in Staphylococcus aureus arthritis in mice.
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Mycobacterium bovis Bacillus Calmette-Guérin killed by extended freeze-drying reduces colitis in mice.
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Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3.
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Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling.
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Autonomic neuroscience : basic & clinical, , Aug-18, Volume: 141, Issue:1-2, 2008

Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice.
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Blocking lymphotoxin beta receptor signalling exacerbates acute DSS-induced intestinal inflammation--opposite functions for surface lymphotoxin expressed by T and B lymphocytes.
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In vivo treatment with the herbal phenylethanoid acteoside ameliorates intestinal inflammation in dextran sulphate sodium-induced colitis.
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Myeloperoxidase immunohistochemical staining can identify glomerular endothelial cell injury in dense deposit disease.
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The Annals of otology, rhinology, and laryngology, , Volume: 125, Issue:6, 2016

Prolonged infections associated with antineutrophil cytoplasmic antibodies specific to proteinase 3 and myeloperoxidase: diagnostic and therapeutic challenge.
Clinical rheumatology, , Volume: 29, Issue:8, 2010

Use of immunofluorescence and confocal laser scanning microscopy in identifying rare cases of anti-neutrophil cytoplasmic antibodies (ANCA) showing dual specificities to myeloperoxidase and proteinase3.
Journal of fluorescence, , Volume: 14, Issue:4, 2004

Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis.
Laboratory investigation; a journal of technical methods and pathology, , Volume: 82, Issue:1, 2002

Renal ischemia/reperfusion injury contributes to renal damage in experimental anti-myeloperoxidase-associated proliferative glomerulonephritis.
Kidney international, , Volume: 47, Issue:4, 1995

Brother and sister with myeloperoxidase associated autoimmune disease.
Annals of the rheumatic diseases, , Volume: 53, Issue:3, 1994

Atypical presence of antimyeloperoxidase antibodies in 2 transplanted patients.
Nephron, , Volume: 63, Issue:4, 1993

Membranous Nephropathy with Proteinase 3-ANCA-associated Vasculitis Successfully Treated with Rituximab.
Internal medicine (Tokyo, Japan), , Jan-01, Volume: 60, Issue:1, 2021

Development of Myeloperoxidase Anti-neutrophil Cytoplasmic Antibody-positive Necrotizing Crescentic Glomerulonephritis in an Elderly Patient with Immunological Kidney Disease.
Internal medicine (Tokyo, Japan), , Dec-15, Volume: 60, Issue:24, 2021

Anti-neutrophil cytoplasmic antibody-associated glomerulonephritis with detection of myeloperoxidase and phospholipase A
BMC nephrology, , 05-23, Volume: 19, Issue:1, 2018

Myeloperoxidase-antineutrophil cytoplasmic antibody causes different renal diseases by immune-complex formation and pauci-immune mechanism: A case report.
Pathology international, , Volume: 67, Issue:8, 2017

A rare case of concurrent myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated necrotising and crescentic glomerulonephritis and membranous glomerulonephritis.
Pathology, , Volume: 49, Issue:1, 2017

Clinical and Immunologic Characteristics of Patients With ANCA-Associated Glomerulonephritis Combined With Membranous Nephropathy: A Retrospective Cohort Study in a Single Chinese Center.
Medicine, , Volume: 94, Issue:37, 2015

Membranous glomerulonephritis with crescents.
International urology and nephrology, , Volume: 46, Issue:5, 2014

Response to "Comment on 'Membranous glomerulonephritis associated with mieloperoxidase antineutrophil cytoplasmic antibody-associated glomerulonephritis'".
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, , Jan-18, Volume: 33, Issue:1, 2013

Comment on "membranous glomerulonephritis associated with mieloperoxidase antineutrophil cytoplasmic antibody-associated glomerulonephritis".
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, , Jan-18, Volume: 33, Issue:1, 2013

A case of myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated glomerulonephritis and concurrent membranous nephropathy.
BMC nephrology, , Mar-28, Volume: 14, 2013

Membranous glomerulonephritis associated with myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, , Jul-17, Volume: 32, Issue:4, 2012

Detection of myeloperoxidase in membranous nephropathy-like deposits in patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.
Human pathology, , Volume: 42, Issue:5, 2011

Sjögren's syndrome with ANCA-associated crescentic extramembranous glomerulonephritis.
Joint bone spine, , Volume: 76, Issue:2, 2009

MPO ANCA-related nephritis associated with membranous glomerulonephropathy.
Internal medicine (Tokyo, Japan), , Volume: 44, Issue:8, 2005

Membranous glomerulopathy induced by myeloperoxidase-anti-neutrophil cytoplasmic antibody-related crescentic glomerulonephritis.
Internal medicine (Tokyo, Japan), , Volume: 44, Issue:8, 2005

Use of immunofluorescence and confocal laser scanning microscopy in identifying rare cases of anti-neutrophil cytoplasmic antibodies (ANCA) showing dual specificities to myeloperoxidase and proteinase3.
Journal of fluorescence, , Volume: 14, Issue:4, 2004

[A case of membranous nephropathy with ANCA-associated necrotizing glomerulonephritis during oral administration of PTU for Graves' disease].
Nihon Jinzo Gakkai shi, , Volume: 45, Issue:8, 2003

[An elderly case of ANCA-positive membranous nephropathy].
Nihon Jinzo Gakkai shi, , Volume: 44, Issue:1, 2002

Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis.
Laboratory investigation; a journal of technical methods and pathology, , Volume: 82, Issue:1, 2002

Myeloperoxidase antineutrophil cytoplasmic antibody-positive necrotizing crescentic glomerulonephritis and membranous glomerulonephropathy.
Clinical nephrology, , Volume: 52, Issue:4, 1999

MPO antibody-positive vasculitis in a patient with psoriatic arthritis and gold-induced membranous glomerulonephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 13, Issue:8, 1998

Myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis with membranous nephropathy in remission.
Internal medicine (Tokyo, Japan), , Volume: 36, Issue:11, 1997

Panniculitis As the First Clinical Manifestation of Myeloperoxidase-Positive Perinuclear Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Comment on the Article by Micheletti et al.
Arthritis & rheumatology (Hoboken, N.J.), , Volume: 73, Issue:6, 2021

Recurrent lipoatrophic panniculitis of children.
Journal of the European Academy of Dermatology and Venereology : JEADV, , Volume: 31, Issue:3, 2017

[ANCA-positive lupus erythematodes profundus. Successful therapy with low dosage dapsone].
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, , Volume: 49, Issue:5, 1998

Clinical and laboratory features associated with myeloperoxidase expression in pediatric B-lymphoblastic leukemia.
Cytometry. Part B, Clinical cytometry, , Volume: 100, Issue:4, 2021

Clinical Significance of Isolated Myeloperoxidase Expression in Pediatric B-Lymphoblastic Leukemia.
American journal of clinical pathology, , 04-01, Volume: 147, Issue:4, 2017

[Application of flow cytometry in the differential diagnosis of lymphoma/leukemia with aberrant antigen expression].
Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 33, Issue:6, 2004

Nature-inspired nanozymes as signal markers for in-situ signal amplification strategy: A portable dual-colorimetric immunochromatographic analysis based on smartphone.
Biosensors & bioelectronics, , Aug-15, Volume: 210, 2022

Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia.
Leukemia, , Volume: 28, Issue:8, 2014

The histone deacetylase inhibitor MGCD0103 induces apoptosis in B-cell chronic lymphocytic leukemia cells through a mitochondria-mediated caspase activation cascade.
Molecular cancer therapeutics, , Volume: 9, Issue:5, 2010

Enzyme levels and G-463A polymorphism of myeloperoxidase in chronic lymphocytic leukemia and multiple myeloma.
Leukemia & lymphoma, , Volume: 50, Issue:12, 2009

Phase II study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia.
British journal of haematology, , Volume: 147, Issue:4, 2009

Catalyzed signal amplification for cyclin D1 detection in mantle cell lymphoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, , Volume: 16, Issue:2, 2003

Detection of low abundance mRNA of myeloid specific genes in cells of acute and chronic lymphoid leukemias by cRNA hybridization.
Leukemia, , Volume: 4, Issue:10, 1990

Chemiluminescence response of polymorphonuclear leucocytes to serum-opsonized zymosan--a predictive parameter for infections and prognosis in multiple myeloma patients.
Clinical and laboratory haematology, , Volume: 10, Issue:4, 1988

Relapsed B-acute lymphoblastic leukemia with aberrant myeloperoxidase expression following CAR T-cell therapy: A diagnostic challenge.
American journal of hematology, , Volume: 94, Issue:9, 2019

Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia.
International journal of cancer, , Jan-10, Volume: 97, Issue:2, 2002

Prevalence of myeloperoxidase gene expression in infant acute lymphocytic leukemia.
American journal of clinical pathology, , Volume: 110, Issue:5, 1998

[Biphenotypic acute leukemia with Ph1 chromosome, M-BCR-, myeloperoxidase+, and CALLA+].
[Rinsho ketsueki] The Japanese journal of clinical hematology, , Volume: 32, Issue:3, 1991

Isolated myeloperoxidase expression in pediatric B/myeloid mixed phenotype acute leukemia is linked with better survival.
Blood, , 02-01, Volume: 131, Issue:5, 2018

Complementarity of evaluation of myeloperoxidase expression by flow cytometry and immunohistochemistry on bone marrow trephine biopsy sections in acute myeloid leukemia.
Cytometry. Part B, Clinical cytometry, , Volume: 86, Issue:1, 2014

A threshold of 10% for myeloperoxidase by flow cytometry is valid to classify acute leukemia of ambiguous and myeloid origin.
Cytometry. Part B, Clinical cytometry, , Volume: 84, Issue:2, 2013

CD117 expression is a sensitive but nonspecific predictor of FLT3 mutation in T acute lymphoblastic leukemia and T/myeloid acute leukemia.
American journal of clinical pathology, , Volume: 137, Issue:2, 2012

Acute leukemias of ambiguous lineage.
Seminars in diagnostic pathology, , Volume: 29, Issue:1, 2012

What is the optimal treatment for biphenotypic acute leukemia?
Haematologica, , Volume: 94, Issue:12, 2009

Spinal cord compression as the initial presentation of acute biphenotypic leukaemia.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 16, Issue:12, 2009

Immunophenotypes in adult acute lymphocytic leukemia. Role of flow cytometry in diagnosis and monitoring of disease.
Hematology/oncology clinics of North America, , Volume: 14, Issue:6, 2000

Mixed-lineage leukemia revisited: acute lymphocytic leukemia with myeloperoxidase-positive blasts by electron microscopy.
Blood, , Aug-15, Volume: 76, Issue:4, 1990

Definition of acute biphenotypic leukemia.
Haematologica, , Volume: 82, Issue:1

[Application of flow cytometry in the differential diagnosis of lymphoma/leukemia with aberrant antigen expression].
Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 33, Issue:6, 2004

Acute biphenotypic leukaemia.
Haematologica, , Volume: 87, Issue:1, 2002

Differentiation of acute myeloid leukemia from B- and T-lineage acute lymphoid leukemias by real-time quantitative reverse transcription-PCR of lineage marker mRNAs.
Clinical chemistry, , Volume: 50, Issue:7, 2004

Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia.
International journal of cancer, , Jan-10, Volume: 97, Issue:2, 2002

Immunophenotypes in adult acute lymphocytic leukemia. Role of flow cytometry in diagnosis and monitoring of disease.
Hematology/oncology clinics of North America, , Volume: 14, Issue:6, 2000

Myeloperoxidase detection by three-color flow cytometry in acute lymphoblastic leukemia.
American journal of clinical pathology, , Volume: 112, Issue:1, 1999

Detection of myeloperoxidase by flow cytometry in acute leukemia.
Cytometry, , Aug-15, Volume: 34, Issue:4, 1998

High prevalence of T cell receptor D delta 2(D delta)J delta rearrangement in CD7-positive early T cell acute lymphoblastic leukemia.
Leukemia, , Volume: 10, Issue:4, 1996

Heterogeneity of CD7+ 4- 8- 1- leukemia: usefulness of cytoplasmic antigen detection for subclassification.
Leukemia, , Volume: 7, Issue:11, 1993

Mature T-lineage leukemia with growth factor-induced multilineage differentiation.
The Journal of experimental medicine, , Mar-01, Volume: 169, Issue:3, 1989

[The immunological effect of anti-leukemic tumor induced by eosinophilic granulocyte].
Zhonghua nei ke za zhi, , Volume: 52, Issue:5, 2013

Leukemia cutis: case report and review of literature.
Applied immunohistochemistry & molecular morphology : AIMM, , Volume: 18, Issue:2, 2010

Serglycin proteoglycan in hematologic malignancies: a marker of acute myeloid leukemia.
Leukemia, , Volume: 21, Issue:12, 2007

Myeloperoxidase cytochemical negativity: an unexpected but intrinsic property of blasts of all phases of chronic myeloid leukemia.
Annals of hematology, , Volume: 84, Issue:12, 2005

Distinguishing between proliferating nodal lymphoid blasts in chronic myelogenous leukemia and non-Hodgkin lymphoma: report of three cases and detection of a bcr/abl fusion signal by single-cell analysis.
Pathology international, , Volume: 55, Issue:5, 2005

[Myeloperoxidase].
Nihon rinsho. Japanese journal of clinical medicine, , Volume: 62 Suppl 12, 2004

Expression of NK-associated antigens in extramedullary lymph nodal blast crisis of chronic myeloid leukemia on fine-needle cytology.
Diagnostic cytopathology, , Volume: 27, Issue:3, 2002

Blast crisis of chronic myelogenous leukemia exhibiting immunophenotypic features of a myeloid/natural killer cell precursor.
International journal of hematology, , Volume: 69, Issue:2, 1999

CD56+ blastic transformation of chronic myeloid leukemia involving the skin.
Journal of cutaneous pathology, , Volume: 26, Issue:10, 1999

Myeloperoxidase mRNA analysis in acute lymphoblastic leukemia.
Diagnostic molecular pathology : the American journal of surgical pathology, part B, , Volume: 6, Issue:3, 1997

The value of the ultrastructural pattern of myeloperoxidase and platelet peroxidase in identification of two blastic cell types during transformation of a chronic myeloproliferative disorder.
Haematologia, , Volume: 27, Issue:3, 1996

Myeloperoxidase mRNA analysis in acute lymphoblastic leukemia.
Diagnostic molecular pathology : the American journal of surgical pathology, part B, , Volume: 5, Issue:4, 1996

Immunophenotype and ultrastructural studies in blast crisis of chronic myeloid leukemia.
Leukemia & lymphoma, , Volume: 19, Issue:3-4, 1995

Establishment of a new cell line with the characteristics of a multipotential progenitor from a patient with chronic myelogenous leukemia in early erythroblastic crisis.
Leukemia, , Volume: 8, Issue:1, 1994

Direct detection of the Philadelphia chromosome in CD20-positive lymphocytes in chronic myeloid leukemia by tri-color immunophenotyping/FISH.
Leukemia, , Volume: 8, Issue:11, 1994

Protection by antibiotics against myeloperoxidase-dependent cytotoxicity to lung epithelial cells in vitro.
The Journal of clinical investigation, , Volume: 91, Issue:1, 1993

Detection of leukemic blasts in peripheral blood specimens by reverse transcriptase polymerase chain reaction assay for myeloperoxidase mRNA.
Diagnostic molecular pathology : the American journal of surgical pathology, part B, , Volume: 2, Issue:4, 1993

Posttranslational processing of defensins in immature human myeloid cells.
Blood, , Mar-15, Volume: 79, Issue:6, 1992

Ultrastructural and ultracytochemical differences between megakaryoblastic leukemia in children and adults. Analysis of 49 patients.
Cancer, , Jul-15, Volume: 70, Issue:2, 1992

Characterization of Philadelphia-chromosome-positive acute leukemia by clinical, immunocytochemical, and gene analysis.
Leukemia, , Volume: 6, Issue:9, 1992

Determination of anti-neutrophil cytoplasm antibodies (ANCA) specificity by immunofluorescence on chronic myelocytic leukemia cells.
Journal of immunological methods, , Feb-14, Volume: 147, Issue:1, 1992

Enhanced granulocyte function in a case of chronic granulocytic leukemia in a dog.
Veterinary immunology and immunopathology, , Volume: 28, Issue:2, 1991

[Biphenotypic acute leukemia with Ph1 chromosome, M-BCR-, myeloperoxidase+, and CALLA+].
[Rinsho ketsueki] The Japanese journal of clinical hematology, , Volume: 32, Issue:3, 1991

Human neutrophil gelatinase is a component of specific granules.
The Journal of clinical investigation, , Volume: 84, Issue:5, 1989

Analysis of human neutrophil granule protein composition in chronic myeloid leukaemia by immuno-electron microscopy.
Cell and tissue research, , Volume: 258, Issue:1, 1989

Expression of the myeloperoxidase gene in acute and chronic myeloid leukemias: relationship to the expression of cell cycle-related genes.
Leukemia, , Volume: 3, Issue:6, 1989

Applicability of using acrylic resins in post-embedding ultrastructural immunolabelling of human neutrophil granule proteins.
The Histochemical journal, , Volume: 21, Issue:5, 1989

Bilineage T-lymphoblastic/myeloid extramedullary blast crisis in chronic myelogenous leukemia.
Indian journal of pathology & microbiology, , Volume: 59, Issue:1

Bone marrow biopsy imprint preparations: use for molecular diagnostics in leukemias.
Annals of clinical and laboratory science, , Volume: 23, Issue:6

Electron microscopic findings of parallel tubular granules in a case of chronic neutrophilic leukaemia.
Journal of clinical pathology, , Volume: 47, Issue:4, 1994

Parallel tubular granules in human immature neutrophils--an electron microscopic study.
Leukemia & lymphoma, , Volume: 15, Issue:1-2, 1994

Acute basophilic leukaemia: eight unsuspected new cases diagnosed by electron microscopy.
British journal of haematology, , Volume: 120, Issue:5, 2003

Acute basophilic leukemia.
European journal of haematology, , Volume: 67, Issue:2, 2001

Flow cytometric analysis of neutrophil myeloperoxidase expression in peripheral blood for ruling out myelodysplastic syndromes: a diagnostic accuracy study.
Haematologica, , Volume: 104, Issue:12, 2019

The value of immunohistochemistry for CD14, CD123, CD33, myeloperoxidase and CD68R in the diagnosis of acute and chronic myelomonocytic leukaemias.
Histopathology, , Volume: 60, Issue:6, 2012

Histologic and immunohistologic characterization of skin localization of myeloid disorders: a study of 173 cases.
American journal of clinical pathology, , Volume: 135, Issue:2, 2011

Splenic pathology in myelodysplasia: a report of 13 cases with clinical correlation.
The American journal of surgical pathology, , Volume: 22, Issue:10, 1998

Extramedullary myeloid cell tumors arising in the setting of chronic myelomonocytic leukemia. A report of two cases.
Archives of pathology & laboratory medicine, , Volume: 120, Issue:1, 1996

The effects of GM-CSF on myeloperoxidase release in normal and myelodysplastic neutrophils.
Leukemia research, , Volume: 17, Issue:12, 1993

Selective involvement of monocytes by acquired myeloperoxidase deficiency in a case of chronic myelomonocytic leukemia.
Annals of hematology, , Volume: 66, Issue:5, 1993

Plasmacytoid T-zone cell proliferation in a patient with chronic myelomonocytic leukemia. Histologic and immunohistologic characterization.
The American journal of surgical pathology, , Volume: 15, Issue:1, 1991

A clinical case of acute myelomonocytic leukemia in a Holstein cow.
The Journal of veterinary medical science, , May-17, Volume: 83, Issue:5, 2021

What lies inside the cup?
European journal of haematology, , Volume: 94, Issue:3, 2015

The value of immunohistochemistry for CD14, CD123, CD33, myeloperoxidase and CD68R in the diagnosis of acute and chronic myelomonocytic leukaemias.
Histopathology, , Volume: 60, Issue:6, 2012

Comparison of myeloperoxidase detection by flow cytometry using two different clones of monoclonal antibodies.
The Malaysian journal of pathology, , Volume: 26, Issue:2, 2004

Acute myeloid leukemia mimicking primary testicular neoplasm. Presentation of a case with review of literature.
European journal of haematology, , Volume: 70, Issue:4, 2003

Acute myeloblastic leukemia (AML) with inv (16)(p13;q22) and the rare I type CBFbeta-MYH11 transcript: report of two new cases.
Leukemia, , Volume: 16, Issue:1, 2002

"Isolated" peritoneal granulocytic sarcoma with molecular and chromosomal bone marrow involvement.
Haematologica, , Volume: 87, Issue:1, 2002

[Total and selective deficiency of myeloperoxidase in peripheral monocytes lead to diagnosis of acute myelomonoblastic leukemia].
Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg, , Volume: 135, Issue:1, 1998

An allelic association implicates myeloperoxidase in the etiology of acute promyelocytic leukemia.
Blood, , Oct-01, Volume: 90, Issue:7, 1997

CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells.
Oncogene, , Volume: 15, Issue:11, 1997

A myeloid-lineage-specific enhancer upstream of the mouse myeloperoxidase (MPO) gene.
Leukemia, , Volume: 8, Issue:5, 1994

Distinct lysozyme content in different subtypes of acute myeloid leukaemic cells: an ultrastructural immunogold study.
British journal of haematology, , Volume: 88, Issue:2, 1994

Acute myelomonocytic leukemia (M4) and t(15;17)(q24;q21). A diagnostic dilemma.
Cancer genetics and cytogenetics, , Oct-01, Volume: 70, Issue:1, 1993

Quantitative enzyme determination in acute myeloid leukemia.
Leukemia research, , Volume: 15, Issue:6, 1991

Acute myelomonocytic leukemia in a horse.
Veterinary pathology, , Volume: 28, Issue:4, 1991

Simultaneous occurrence of myelomonocytic leukemia and multiple myeloma: involvement of common leukemic progenitors and their developmental abnormality of "lineage infidelity".
Journal of cellular physiology, , Volume: 148, Issue:3, 1991

[Spontaneous differentiation from myeloperoxidase-negative acute nonlymphocytic leukemia to acute myelomonocytic leukemia].
[Rinsho ketsueki] The Japanese journal of clinical hematology, , Volume: 30, Issue:10, 1989

[A study of free radical defense and oxidative stress in the sera of patients with neuroimmunological disorders].
Arerugi = [Allergy], , Volume: 49, Issue:1, 2000

Nasal complaints and signs of disease in farmers--a methodological study.
Acta oto-laryngologica, , Volume: 128, Issue:2, 2008

Influence of personal factors on nasal patency and lavage biomarkers in white-collar workers.
Rhinology, , Volume: 38, Issue:3, 2000

Nasal patency and biomarkers in nasal lavage--the significance of air exchange rate and type of ventilation in schools.
International archives of occupational and environmental health, , Volume: 71, Issue:7, 1998

A novel model for studying ileitis-induced visceral hypersensitivity in goats.
Acta veterinaria Scandinavica, , Oct-06, Volume: 58, Issue:1, 2016

The apicomplexan parasite Eimeria arloingi induces caprine neutrophil extracellular traps.
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Antioxidant enzymes in erythrocytes from goats seropositive to the sheep nose bot fly (Oestrus ovis L., Diptera: Oestridae) infection.
Veterinary parasitology, , Dec-29, Volume: 183, Issue:1-2, 2011

[Course changes in acute inflammation of the frontal sinus based on the indices of lipid peroxidation and on the activity of enzyme during biovibration therapy].
Vestnik otorinolaringologii, , Issue:1, 1998

Use of pharmacodynamic endpoints for the evaluation of levofloxacin for the treatment of acute maxillary sinusitis.
Diagnostic microbiology and infectious disease, , Volume: 61, Issue:1, 2008

Proteomic analyses of monocytes obtained from Hispanic women with HIV-associated dementia show depressed antioxidants.
Proteomics. Clinical applications, , Volume: 4, Issue:8-9, 2010

Assessment of serum and synovial fluid MMP-3 and MPO as biomarkers for psoriatic arthritis and their relation to disease activity indices.
Rheumatology international, , Volume: 42, Issue:9, 2022

NETosis in Psoriatic Arthritis: Serum MPO-DNA Complex Level Correlates With Its Disease Activity.
Frontiers in immunology, , Volume: 13, 2022

Genetic Analysis of MPO Variants in Four Psoriasis Subtypes in Patients from Germany.
The Journal of investigative dermatology, , Volume: 141, Issue:8, 2021

Differentiating Psoriatic Arthritis From Psoriasis Without Psoriatic Arthritis Using Novel Serum Biomarkers.
Arthritis care & research, , Volume: 70, Issue:3, 2018

MPO antibody-positive vasculitis in a patient with psoriatic arthritis and gold-induced membranous glomerulonephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 13, Issue:8, 1998

Antineutrophil cytoplasmic antibodies in rheumatoid arthritis patients.
British journal of rheumatology, , Volume: 35, Issue:1, 1996

Myeloperoxidase and Other Markers of Neutrophil Activation Associate With Malaria and Malaria/HIV Coinfection in the Human Placenta.
Frontiers in immunology, , Volume: 12, 2021

Investigating the histopathological findings and immunolocalization of rickettsialpox infection in skin biopsies: A case series and review of the literature.
Journal of cutaneous pathology, , Volume: 47, Issue:5, 2020

Neutrophil Vaccination Dynamics and Their Capacity To Mediate B Cell Help in Rhesus Macaques.
Journal of immunology (Baltimore, Md. : 1950), , 10-15, Volume: 201, Issue:8, 2018

Relationship between plasma bilirubin level and oxidative stress markers in HIV-infected patients on atazanavir- vs. efavirenz-based antiretroviral therapy.
HIV medicine, , Volume: 17, Issue:9, 2016

Myeloperoxidase in human peripheral blood lymphocytes: Production and subcellular localization.
Cellular immunology, , Volume: 300, 2016

Plasma plasminogen activator inhibitor-1 predicts myocardial infarction in HIV-1-infected individuals.
AIDS (London, England), , May-15, Volume: 28, Issue:8, 2014

Changes of metabolic and inflammatory markers in HIV infection: glucose, lipids, serum Hs-CRP and myeloperoxidase.
Metabolism: clinical and experimental, , Volume: 61, Issue:10, 2012

Relationship between inflammatory markers, endothelial activation markers, and carotid intima-media thickness in HIV-infected patients receiving antiretroviral therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, , Oct-01, Volume: 49, Issue:7, 2009

Changes in biomarkers of cardiovascular risk after a switch to abacavir in HIV-1-infected individuals receiving combination antiretroviral therapy.
HIV medicine, , Volume: 10, Issue:10, 2009

Increased carotid intima media thickness and cardiac biomarkers in HIV infected children.
AIDS (London, England), , May-11, Volume: 21, Issue:8, 2007

The evaluation of lysozyme concentration and peroxidase activity in non-stimulated saliva of patients infected with HIV.
Advances in medical sciences, , Volume: 51 Suppl 1, 2006

The saliva immunology mechanisms and periodontal status in HIV infected subjects.
Advances in medical sciences, , Volume: 51 Suppl 1, 2006

Impaired phagocyte oxidative capacity in human immunodeficiency virus-infected children.
The Journal of infectious diseases, , Volume: 179, Issue:3, 1999

Quantitative, competitive PCR assay for HIV-1 using a microplate-based detection system.
BioTechniques, , Volume: 24, Issue:5, 1998

Matrix metalloproteinases-1, -3 and -8 and myeloperoxidase in saliva of patients with human immunodeficiency virus infection.
Oral diseases, , Volume: 2, Issue:4, 1996

Use of antineutrophil cytoplasmic autoantibodies in diagnosing vasculitis in a Chinese patient population.
American journal of nephrology, , Volume: 14, Issue:2, 1994

Anti-nuclear, anti-neutrophil cytoplasmic and anti-glomerular basement membrane antibodies in HIV-infected individuals.
Autoimmunity, , Volume: 18, Issue:3, 1994

Anti-neutrophil cytoplasm antibodies in HIV infection.
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Viricidal effect of Lactobacillus acidophilus on human immunodeficiency virus type 1: possible role in heterosexual transmission.
The Journal of experimental medicine, , Jul-01, Volume: 174, Issue:1, 1991

Higher plasma myeloperoxidase levels are not associated with an increased risk for cardiovascular events in HIV-infected adults.
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[Morphological characteristics of inflammation in HIV-associated pulmonary tuberculosis with regard to the expression of myeloperoxidase].
Arkhiv patologii, , Volume: 77, Issue:6

Clinical and pro-host effects of cefaclor in prophylaxis of recurrent otitis media in HIV-infected children.
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Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition.
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Using Naturally Occurring Bioluminescent Enzymes to Track Specific Cell Populations.
Methods in molecular biology (Clifton, N.J.), , Volume: 2126, 2020

Proteome Analyses Reveal Positive Association of COL2A1, MPO, TYMS, and IGFBP5 with Canine Mammary Gland Malignancy.
Proteomics. Clinical applications, , Volume: 13, Issue:4, 2019

Inhibition of carcinogen-induced rat mammary tumor growth and other estrogen-dependent responses by symmetrical dihalo-substituted analogs of diindolylmethane.
Cancer letters, , Apr-14, Volume: 151, Issue:2, 2000

Evaluation of anti-inflammatory activity of the methanolic extract from Jungia rugosa leaves in rodents.
Journal of ethnopharmacology, , Sep-15, Volume: 173, 2015

Anti-inflammatory and antinociceptive properties of blueberry extract (Vaccinium corymbosum).
The Journal of pharmacy and pharmacology, , Volume: 59, Issue:4, 2007

ANCA and IgA glomerulonephritis all in one: prognosis and complications.
BMJ case reports, , Oct-09, Volume: 2017, 2017

Beneficial effects of the ethanol extract of Caesalpinia pyramidalis on the inflammatory response and abdominal hyperalgesia in rats with acute pancreatitis.
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Serine proteases mediate inflammatory pain in acute pancreatitis.
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[A rare tumor of the main biliary duct].
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Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice.
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[A-leukemic caecal myeloid sarcoma: a difficult diagnosis].
Annales de pathologie, , Volume: 24, Issue:5, 2004

Acute myeloid leukemia mimicking primary testicular neoplasm. Presentation of a case with review of literature.
European journal of haematology, , Volume: 70, Issue:4, 2003

Role of interleukin-6 in a glucan-induced model of granulomatous vasculitis.
Experimental and molecular pathology, , Volume: 82, Issue:2, 2007

[Some hematologic specific features of penetrating ocular injuries in children of Turkmenistan].
Vestnik oftalmologii, , Volume: 119, Issue:2

0.01% Hypochlorous Acid Treats Aspergillus fumigatus Keratitis in Rats by Reducing Fungal Load and Inhibiting the Inflammatory Response.
Translational vision science & technology, , 08-01, Volume: 12, Issue:8, 2023

CLEC-1 Acts as a Negative Regulator of Dectin-1 Induced Host Inflammatory Response Signature in Aspergillus fumigatus Keratitis.
Investigative ophthalmology & visual science, , 05-03, Volume: 62, Issue:6, 2021

Wedelolactone suppresses IL-1β maturation and neutrophil infiltration in Aspergillus fumigatus keratitis.
International immunopharmacology, , Volume: 73, 2019

Exacerbation of Acanthamoeba keratitis in animals treated with anti-macrophage inflammatory protein 2 or antineutrophil antibodies.
Infection and immunity, , Volume: 69, Issue:5, 2001

Adenovirus type 37 keratitis in the C57BL/6J mouse.
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Opsoclonus as a manifestation of Hashimoto's encephalopathy.
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[A case of myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA)-related glomerulonephritis associated with Cogan's syndrome].
Nihon Jinzo Gakkai shi, , Volume: 38, Issue:9, 1996

Microscopic polyangiitis complicated by oculomotor nerve palsy.
Japanese journal of ophthalmology, , Volume: 57, Issue:2, 2013

Early Depletion of Neutrophils Reduces Retinal Inflammation and Neovascularization in Mice with Oxygen-Induced Retinopathy.
International journal of molecular sciences, , Oct-27, Volume: 24, Issue:21, 2023

Fish oil before cardiac surgery: neutrophil activation is unaffected but myocardial damage is moderated.
Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 72, Issue:4, 2005

Leucodepletion during cardiopulmonary bypass reduces blood transfusion and crystalloid requirements.
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Inhibition of platelet adhesion during cardiopulmonary bypass reduces postoperative bleeding.
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Increased RANKL and IL-6 levels might result in high bone turnover in a case of a CD34+/CD117+/myeloperoxidase(+dim) acute myeloid leukemia presenting with severe hypercalcemia and lumbar spine fractures.
Leukemia research, , Volume: 35, Issue:11, 2011

Leukocyte myeloperoxidase and pathogenesis of the post-polio syndrome.
Scandinavian journal of infectious diseases, , Volume: 42, Issue:11-12, 2010

Gastrointestinal sensitivity to soy and milk proteins in patients with IgA nephropathy.
Clinical nephrology, , Volume: 74, Issue:5, 2010

Self-reported food intolerance and mucosal reactivity after rectal food protein challenge in patients with rheumatoid arthritis.
Scandinavian journal of rheumatology, , Volume: 39, Issue:4, 2010

Cow's milk protein sensitivity assessed by the mucosal patch technique is related to irritable bowel syndrome in patients with primary Sjögren's syndrome.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 38, Issue:6, 2008

Mucosal reactivity to cow's milk protein in coeliac disease.
Clinical and experimental immunology, , Volume: 147, Issue:3, 2007

A 70-year-old man with pulmonary infiltrates and a positive antineutrophil cytoplasmic autoantibody test result.
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Myeloperoxidase-positive intravascular large B-cell lymphoma.
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Cephotaxime-associated allergic interstitial nephritis and MPO-ANCA positive vasculitis.
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Human eosinophil peroxidase enhances tumor necrosis factor and hydrogen peroxide release by human monocyte-derived macrophages.
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A case of intravascular large B-cell lymphoma with renal involvement presenting with elevated serum ANCA titers.
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T-cell/histiocyte-rich large B-cell lymphoma with zonal expansion of fibroblastic reticulum cells and infiltration by a subpopulation of myeloperoxidase positive histiocytes.
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[Granulocytic sarcoma: a clinical and pathologic analysis of ten cases].
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Evaluation of myeloperoxidase in synovial fluid as a biomarker for chronic periprosthetic joint infection.
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Systemic inflammatory response induced by dacron graft and modulation by antimicrobial agents: experimental study.
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Promyelocytic Differentiation in Infiltrates of Prurigo Pigmentosa: An Analogy to Histiocytoid Sweet Syndrome.
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Utility of myeloperoxidase stain in the differential diagnosis of leukemia cutis vs. hystiocitoid Sweet syndrome.
Dermatology online journal, , Apr-15, Volume: 17, Issue:4, 2011

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Histiocytoid Sweet's Syndrome: A localized cutaneous proliferation of macrophages frequently associated with chronic myeloproliferative disease.
European journal of dermatology : EJD, , Volume: 25, Issue:4

Elevated MMP-8 and decreased myeloperoxidase concentrations associate significantly with the risk for peripheral atherosclerosis disease and abdominal aortic aneurysm.
Scandinavian journal of immunology, , Volume: 72, Issue:2, 2010

Association of serum myeloperoxidase with the ankle-brachial index and peripheral arterial disease.
Vascular medicine (London, England), , Volume: 14, Issue:3, 2009

Peripheral arterial disease enters the biomarker era. Does risk stratification tell us something that we don't already know?
European heart journal, , Volume: 29, Issue:2, 2008

Myeloperoxidase, but not C-reactive protein, predicts cardiovascular risk in peripheral arterial disease.
European heart journal, , Volume: 29, Issue:2, 2008

Omega-3 polyunsaturated fatty acid in peripheral arterial disease: effect on lipid pattern, disease severity, inflammation profile, and endothelial function.
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Selective activation of the prostaglandin E2 circuit in chronic injury-induced pathologic angiogenesis.
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Exacerbated corneal inflammation and neovascularization in the HO-2 null mice is ameliorated by biliverdin.
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Cerebrospinal fluid involvement in acute promyelocytic leukaemia at presentation.
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Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia.
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[no title available]
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Planta medica, , Volume: 77, Issue:18, 2011

Lactobacillus johnsonii HY7042 ameliorates Gardnerella vaginalis-induced vaginosis by killing Gardnerella vaginalis and inhibiting NF-κB activation.
International immunopharmacology, , Volume: 11, Issue:11, 2011

Second primary tumors and myeloperoxidase expression in buccal mucosal squamous cell carcinoma.
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Cytochemically myeloperoxidase positive childhood acute leukemia with lymphoblastic morphology treated as lymphoblastic leukemia.
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Early prolonged neutrophil activation in critically ill patients with sepsis.
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Circulating myeloperoxidase is elevated in septic shock and is associated with systemic organ failure and mortality in critically ill patients.
Free radical biology & medicine, , 05-20, Volume: 152, 2020

Critical COPD respiratory illness is linked to increased transcriptomic activity of neutrophil proteases genes.
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Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis.
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Neutrophil Extracellular Traps May Contribute to the Pathogenesis in Adult-onset Still Disease.
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Hepatitis-E-virus-associated antigen: improved detection in stools by protein Fv removal.
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Comparative Cardiac Safety of Selective Serotonin Reuptake Inhibitors among Individuals Receiving Maintenance Hemodialysis.
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Myeloperoxidase is associated with incident coronary heart disease independently of traditional risk factors: results from the MONICA/KORA Augsburg study.
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Myeloperoxidase and plaque vulnerability.
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Identification and characterization of myeloperoxidase in orange-spotted grouper (Epinephelus coioides).
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Dietary supplementation with chitin and chitosan on haematology and innate immune response in Epinephelus bruneus against Philasterides dicentrarchi.
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Turbot resistance to Philasterides dicentrarchi is more dependent on humoral than on cellular immune responses.
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Glucantime reduces mechanical hyperalgesia in cutaneous leishmaniasis and complete Freund's adjuvant models of chronic inflammatory pain.
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Enzymatic Mechanism of Leishmania major Peroxidase and the Critical Role of Specific Ionic Interactions.
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Protection against peroxynitrite by pseudoperoxidase from Leishmania major.
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Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors.
Immunology, , Volume: 130, Issue:2, 2010

Prevalence of malaria and associated clinical manifestations and myeloperoxidase amongst populations living in different altitudes of Mezam division, North West Region, Cameroon.
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Human neutrophil lipocalin: a specific marker for neutrophil activation in severe Plasmodium falciparum malaria.
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Molecular Imaging Unravels Cerebral Malaria.
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Neutrophil leucocyte activation in severe malaria.
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Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology.
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Role of MIP-2 in neutrophil migration and tissue injury in the herpes simplex virus-1-infected cornea.
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Acute inflammation and loss of retinal architecture and function during experimental Bacillus endophthalmitis.
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Fucoidan interferes with Porphyromonas gingivalis-induced aneurysm enlargement by decreasing neutrophil activation.
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The periodontal pathogen Porphyromonas gingivalis harnesses the chemistry of the mu-oxo bishaem of iron protoporphyrin IX to protect against hydrogen peroxide.
FEMS microbiology letters, , Feb-01, Volume: 183, Issue:1, 2000

3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants: association with adverse respiratory outcome.
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Quantitative and qualitative leukocyte abnormalities in dogs with experimental and naturally occurring acute canine monocytic ehrlichiosis.
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Human granulocytic ehrlichiosis agent and Ehrlichia chaffeensis reside in different cytoplasmic compartments in HL-60 cells.
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Elevated Leukocyte Azurophilic Enzymes in Human Diabetic Ketoacidosis Plasma Degrade Cerebrovascular Endothelial Junctional Proteins.
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[PHENOTYPE OF PERIPHERAL BLOOD NEUTROPHILS IN THE INITIAL STAGE OF ENDOMETRIAL CANCER].
Tsitologiia, , Volume: 58, Issue:1, 2016

[The plasma level of sL-selectin, myeloperoxidase (MPO) and granulocyte-colony stimulating factor (G-CSF) in gynecological cancer patients].
Przeglad lekarski, , Volume: 67, Issue:3, 2010

Switching (overtargeting) of estrogen effects and its potential role in hormonal carcinogenesis.
Neoplasma, , Volume: 49, Issue:1, 2002

Increased myeloperoxidase and lipid peroxide-modified protein in gynecological malignancies.
Antioxidants & redox signaling, , Volume: 3, Issue:6, 2001

Myeloperoxidase-antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis in autosomal dominant polycystic kidney disease.
BMC nephrology, , Apr-23, Volume: 14, 2013

Circulating levels of soluble adhesion molecules in patients with ANCA-associated vasculitis.
Journal of nephrology, , Volume: 17, Issue:6

Plasma myeloperoxidase levels in acute brain ischaemia and high grade carotid stenosis.
European journal of neurology, , Volume: 27, Issue:8, 2020

N
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 26, Issue:6, 2017

Serum levels of anti-apolipoprotein A-1 auto-antibodies and myeloperoxidase as predictors of major adverse cardiovascular events after carotid endarterectomy.
Thrombosis and haemostasis, , Volume: 109, Issue:4, 2013

Clinical significance of active myeloperoxidase in carotid atherosclerotic plaques.
International journal of cardiology, , Oct-06, Volume: 152, Issue:1, 2011

Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes.
Arteriosclerosis, thrombosis, and vascular biology, , Volume: 26, Issue:12, 2006

Myeloperoxidase predicts progression of carotid stenosis in states of low high-density lipoprotein cholesterol.
Journal of the American College of Cardiology, , Jun-06, Volume: 47, Issue:11, 2006

Topical application of phenolic compounds suppresses Propionibacterium acnes-induced inflammatory responses in mice with ear edema.
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Adherent/invasive capacities of bovine-associated Aerococcus viridans contribute to pathogenesis of acute mastitis in a murine model.
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Five-year longitudinal assessment (2008 to 2012) of E-101 solution activity against clinical target and antimicrobial-resistant pathogens.
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The SKPO-1 peroxidase functions in the hypodermis to protect Caenorhabditis elegans from bacterial infection.
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Contribution of the myeloperoxidase-dependent oxidative system to host defence against Cryptococcus neoformans.
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[An elderly case of ANCA-positive membranous nephropathy].
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Oxidative stress, cytokine/chemokine and disruption of blood-brain barrier in neonate rats after meningitis by Streptococcus agalactiae.
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Oxidative stress and myeloperoxidase activity during bacterial meningitis: effects of febrile episodes and the BBB permeability.
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Common variable immunodeficiency patients display elevated plasma levels of granulocyte activation markers elastase and myeloperoxidase.
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Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo.
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Probiotics-pathogen interactions elicit differential regulation of cutaneous immune responses in epidermal cells of Atlantic cod Gadus morhua.
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mocetinostat

Description

Cross-References

Synonyms (74)

Roles (6)

Drug Classes (6)

Protein Targets (27)

Potency Measurements

Inhibition Measurements

Bioassays (250)

Research

Studies (20,895)

Study Types

Safety/Toxicity (268)

Long-term Use (28)

Pharmacokinetics (53)

Bioavailability (97)

Dosage (242)

Interactions (29)

Natural Sources (2)

Article	Year
Galectin-3 and Myeloperoxidase May Monitor Cancer-Therapy-Related Cardiotoxicity? A Systematic Review and Meta-Analysis. Biomolecules, , 11-30, Volume: 12, Issue:12	2022
Quercetin Protected from Aluminum Phosphide-induced Acute and Subacute Cardio- and Hepatotoxicity in Rats. Current pharmaceutical design, , Volume: 28, Issue:43	2022
Asparagus racemosus improves immune-related parameters in Nile tilapia (Oreochromis niloticus) and mitigates deltamethrin-induced toxicity. Fish & shellfish immunology, , Volume: 130	2022
Phellinus linteus polysaccharides mediates acetaminophen-induced hepatotoxicity via activating AMPK/Nrf2 signaling pathways. Aging, , Sep-01, Volume: 14, Issue:17	2022
Zinc oxide nanoparticles (ZnO-NPs) exhibit immune toxicity to crucian carp (Carassius carassius) by neutrophil extracellular traps (NETs) release and oxidative stress. Fish & shellfish immunology, , Volume: 129	2022
The efficacy and safety of mizoribine for maintenance therapy in patients with myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis: the usefulness of serum mizoribine monitoring. Clinical and experimental nephrology, , Volume: 26, Issue:11	2022
Amelioration of lead toxicity by ascorbic acid in sugarcane (Saccharum officinarum L.) under in vitro condition. Environmental science and pollution research international, , Volume: 29, Issue:56	2022
Evaluation of the toxicity effects of microplastics and cadmium on earthworms. The Science of the total environment, , Aug-25, Volume: 836	2022
Glutamine Is a Superior Protector Against Lead-Induced Hepatotoxicity in Rats via Antioxidant, Anti-inflammatory, and Chelating Properties. Biological trace element research, , Volume: 200, Issue:11	2022
Quercetin inhibits neutrophil extracellular traps release and their cytotoxic effects on A549 cells, as well the release and enzymatic activity of elastase and myeloperoxidase. Brazilian journal of biology = Revista brasleira de biologia, , Volume: 84	2022
Toxicity and tissue accumulation characteristics of the herbicide pendimethalin under silicon application in ginger (Zingiber officinale Roscoe). Environmental science and pollution research international, , Volume: 29, Issue:17	2022
Chrysin attenuates sodium arsenite-induced nephrotoxicity in rats by suppressing oxidative stress and inflammation. Tissue & cell, , Volume: 73	2021
Regulation of Keap-1/Nrf2/AKT and iNOS/NF-κB/TLR4 signals by apocynin abrogated methotrexate-induced testicular toxicity: Mechanistic insights and computational pharmacological analysis. Life sciences, , Nov-01, Volume: 284	2021
Diethylenetriamine/NONOate-doped alginate hydrogel with sustained nitric oxide release and minimal toxicity to accelerate healing of MRSA-infected wounds. Carbohydrate polymers, , Oct-15, Volume: 270	2021
Inhibition of Sp1-mediated survivin and MCL1 expression cooperates with SLC35F2 and myeloperoxidase to modulate YM155 cytotoxicity to human leukemia cells. Biochemical pharmacology, , Volume: 188	2021
ZnO nanoparticle-based seed priming modulates early growth and enhances physio-biochemical and metabolic profiles of fragrant rice against cadmium toxicity. Journal of nanobiotechnology, , Mar-17, Volume: 19, Issue:1	2021
Sulfur supply reduces barium toxicity in Tanzania guinea grass (Panicum maximum) by inducing antioxidant enzymes and proline metabolism. Ecotoxicology and environmental safety, , Jan-15, Volume: 208	2021
Treatment-related damage in elderly-onset ANCA-associated vasculitis: safety outcome analysis of two nationwide prospective cohort studies. Arthritis research & therapy, , 10-12, Volume: 22, Issue:1	2020
5-aminolevulinic acid regulates Krebs cycle, antioxidative system and gene expression in Brassica juncea L. to confer tolerance against lead toxicity. Journal of biotechnology, , Nov-10, Volume: 323	2020
Biochemical adaptation of wild and cultivated soybean against toxicity of lead salts. Environmental toxicology and pharmacology, , Volume: 79	2020
Comparative ecotoxicity of single and binary mixtures exposures of cadmium and zinc on growth and biomarkers of Lemna gibba. Ecotoxicology (London, England), , Volume: 29, Issue:5	2020
Gonadoprotective ability of Vincetoxicum arnottianum extract against bisphenol A-induced testicular toxicity and hormonal imbalance in male Sprague Dawley rats. Andrologia, , Volume: 52, Issue:6	2020
The possible neurobehavioral protective effects of natural antioxidant against phototoxicity attenuation of antimicrobial quinolone group in rats. Journal of biochemical and molecular toxicology, , Volume: 34, Issue:7	2020
Phytotoxicity assay to assess sewage sludge phytoremediation rate using guaiacol peroxidase activity (GPX): A comparison of four growth substrates. Journal of environmental management, , Jun-01, Volume: 263	2020
[Сurrent views on predictors and biomarkers of early diagnosis of anthracycline-mediated cardiotoxicity in patients with breast cancer (review of literature).] Klinicheskaia laboratornaia diagnostika, , Volume: 65, Issue:3	2020
Phytotoxicity, Bioaccumulation, and Degradation of Nonylphenol in Different Microalgal Species without Bacterial Influences. International journal of molecular sciences, , Feb-17, Volume: 21, Issue:4	2020
Spermine ameliorates prolonged fluoride toxicity in soil-grown rice seedlings by activating the antioxidant machinery and glyoxalase system. Ecotoxicology and environmental safety, , Volume: 189	2020
Melatonin ameliorates sodium valproate-induced hepatotoxicity in rats. Molecular biology reports, , Volume: 47, Issue:1	2020
A case of anti-neutrophil cytoplasmic antibody-associated vasculitis with anti-glomerular basement membrane antibodies that was successfully treated with mizoribine as a safe and effective remission maintenance therapy with prednisolone and plasma exchang CEN case reports, , Volume: 9, Issue:1	2020
Combined toxic effects of microcystin-LR and phenanthrene on growth and antioxidant system of duckweed (Lemna gibba L.). Ecotoxicology and environmental safety, , Dec-15, Volume: 185	2019
Protective Responses Induced by Chiral 3-Dichloroacetyl Oxazolidine Safeners in Maize ( Molecules (Basel, Switzerland), , Aug-22, Volume: 24, Issue:17	2019
Increased whitening efficacy and reduced cytotoxicity are achieved by the chemical activation of a highly concentrated hydrogen peroxide bleaching gel. Journal of applied oral science : revista FOB, , Aug-12, Volume: 27	2019
Calcium amendment improved the performance of fragrant rice and reduced metal uptake under cadmium toxicity. Environmental science and pollution research international, , Volume: 26, Issue:24	2019
Phytotoxicity and oxidative stress of perfluorooctanesulfonate to two riparian plants: Acorus calamus and Phragmites communis. Ecotoxicology and environmental safety, , Sep-30, Volume: 180	2019
Increased antioxidative capacity and decreased cadmium uptake contribute to hemin-induced alleviation of cadmium toxicity in Chinese cabbage seedlings. Ecotoxicology and environmental safety, , Aug-15, Volume: 177	2019
Comparative Cardiac Safety of Selective Serotonin Reuptake Inhibitors among Individuals Receiving Maintenance Hemodialysis. Journal of the American Society of Nephrology : JASN, , Volume: 30, Issue:4	2019
Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase I study in healthy volunteers. British journal of clinical pharmacology, , Volume: 85, Issue:4	2019
Salicylic acid alleviates thiram toxicity by modulating antioxidant enzyme capacity and pesticide detoxification systems in the tomato (Solanum lycopersicum Mill.). Plant physiology and biochemistry : PPB, , Volume: 135	2019
Assessing the Safety and Efficacy of Lactobacillus plantarum MTCC 5690 and Lactobacillus fermentum MTCC 5689 in Colitis Mouse Model. Probiotics and antimicrobial proteins, , Volume: 11, Issue:3	2019
Acute toxicity of the fungicide azoxystrobin on the diatom Phaeodactylum tricornutum. Ecotoxicology and environmental safety, , Jan-30, Volume: 168	2019
Usefulness of myeloperoxidase as a biomarker for the ranking of pulmonary toxicity of nanomaterials. Particle and fibre toxicology, , 10-23, Volume: 15, Issue:1	2018
Exogenous foliar application of fulvic acid alleviate cadmium toxicity in lettuce (Lactuca sativa L.). Ecotoxicology and environmental safety, , Jan-15, Volume: 167	2019
Adsorption of Plasma Proteins on Single-Walled Carbon Nanotubes Reduced Cytotoxicity and Modulated Neutrophil Activation. Chemical research in toxicology, , 10-15, Volume: 31, Issue:10	2018
Boron inhibits aluminum-induced toxicity to citrus by stimulating antioxidant enzyme activity. Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews, , Volume: 36, Issue:3	2018
Reno-protective effects of ursodeoxycholic acid against gentamicin-induced nephrotoxicity through modulation of NF-κB, eNOS and caspase-3 expressions. Cell and tissue research, , Volume: 374, Issue:2	2018
Aluminium toxicity and phosphate deficiency activates antioxidant systems and up-regulates expression of phosphate transporters gene in ryegrass (Lolium perenne L.) plants. Plant physiology and biochemistry : PPB, , Volume: 130	2018
Fibrinogen binding-dependent cytotoxicity and degradation of single-walled carbon nanotubes. Journal of materials science. Materials in medicine, , Jul-17, Volume: 29, Issue:8	2018
Reduced phytotoxicity of propazine on wheat, maize and rapeseed by salicylic acid. Ecotoxicology and environmental safety, , Oct-30, Volume: 162	2018
[Protection of Herba Scutellariae Barbatae against hepatotoxicity induced by Rhizoma Dioscoreae Bulbiferae and its mechanism]. Yao xue xue bao = Acta pharmaceutica Sinica, , Volume: 51, Issue:3	2016
Acute toxicity and associated mechanisms of four strobilurins in algae. Environmental toxicology and pharmacology, , Volume: 60	2018
Alleviation of iron toxicity in Schinus terebinthifolius Raddi (Anacardiaceae) by humic substances. Environmental science and pollution research international, , Volume: 25, Issue:10	2018
Hepatotoxicity of bisphenol A under conditions of differential supplementation with retinoids. Ukrainian biochemical journal, , Volume: 88, Issue:3
Toxic effects and mechanism of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on Lemna minor. Chemosphere, , Volume: 193	2018
Evaluation of heme oxygenase 1 (HO 1) in Cd and Ni induced cytotoxicity and crosstalk with ROS quenching enzymes in two to four leaf stage seedlings of Vigna radiata. Protoplasma, , Volume: 255, Issue:2	2018
Oxidative Damage and Genetic Toxicity Induced by DBP in Earthworms (Eisenia fetida). Archives of environmental contamination and toxicology, , Volume: 74, Issue:4	2018
Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats. Environmental toxicology and pharmacology, , Volume: 54	2017
Alterations in growth, oxidative damage, and metal uptake of five aromatic rice cultivars under lead toxicity. Plant physiology and biochemistry : PPB, , Volume: 115	2017
Toxicity of diesel water accommodated fraction toward microalgae, Pseudokirchneriella subcapitata and Chlorella sp. MM3. Ecotoxicology and environmental safety, , Volume: 142	2017
Antioxidant and antiapoptotic effects of sea cucumber and valsartan against doxorubicin-induced cardiotoxicity in rats: The role of low dose gamma irradiation. Journal of photochemistry and photobiology. B, Biology, , Volume: 170	2017
Toxicity effects of di-(2-ethylhexyl) phthalate to Eisenia fetida at enzyme, cellular and genetic levels. PloS one, , Volume: 12, Issue:3	2017
Physiological highlights of manganese toxicity symptoms in soybean plants: Mn toxicity responses. Plant physiology and biochemistry : PPB, , Volume: 113	2017
Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties. Expert opinion on drug metabolism & toxicology, , Volume: 13, Issue:5	2017
Atorvastatin protected from paraquat-induced cytotoxicity in alveolar macrophages via down-regulation of TLR-4. Environmental toxicology and pharmacology, , Volume: 49	2017
Co-application of 6-ketone type brassinosteroid and metal chelator alleviates cadmium toxicity in B. juncea L. Environmental science and pollution research international, , Volume: 24, Issue:1	2017
Remediation of cadmium toxicity in field peas (Pisum sativum L.) through exogenous silicon. Ecotoxicology and environmental safety, , Volume: 135	2017
Zinc oxide nanoparticles (ZnONPs) alleviate heavy metal-induced toxicity in Leucaena leucocephala seedlings: A physiochemical analysis. Plant physiology and biochemistry : PPB, , Volume: 110	2017
Biochemical Profile, Biological Activities, and Toxic Effects of Proteins in the Rhinella schneideri Parotoid Gland Secretion. Journal of experimental zoology. Part A, Ecological genetics and physiology, , Volume: 325, Issue:8	2016
Methotrexate Locally Released from Poly(e-Caprolactone) Implants: Inhibition of the Inflammatory Angiogenesis Response in a Murine Sponge Model and the Absence of Systemic Toxicity. Journal of pharmaceutical sciences, , Volume: 104, Issue:11	2015
Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model. Radiation research, , Volume: 186, Issue:2	2016
Potential of morin and hesperidin in the prevention of cisplatin-induced nephrotoxicity. Renal failure, , Volume: 38, Issue:8	2016
Transcriptomic and physiological analysis of common duckweed Lemna minor responses to NH4(+) toxicity. BMC plant biology, , Apr-18, Volume: 16	2016
Toxicity of OTC to Ipomoea aquatica Forsk. and to microorganisms in a long-term sewage-irrigated farmland soil. Environmental science and pollution research international, , Volume: 23, Issue:15	2016
Reduction of chlorpyrifos-induced toxicity in human lymphocytes by selected phosphodiesterase inhibitors. Pesticide biochemistry and physiology, , Volume: 128	2016
Dietary protocatechuic acid ameliorates dextran sulphate sodium-induced ulcerative colitis and hepatotoxicity in rats. Food & function, , Volume: 7, Issue:2	2016
The interaction of salicylic acid and Ca(2+) alleviates aluminum toxicity in soybean (Glycine max L.). Plant physiology and biochemistry : PPB, , Volume: 98	2016
Agmatine improves renal function in gentamicin-induced nephrotoxicity in rats. Canadian journal of physiology and pharmacology, , Volume: 94, Issue:3	2016
Quaternary ammonium salts with tetrafluoroborate anion: Phytotoxicity and oxidative stress in terrestrial plants. Journal of hazardous materials, , Mar-05, Volume: 304	2016
Terminalia arjuna bark extract alleviates nickel toxicity by suppressing its uptake and modulating antioxidative defence in rice seedlings. Protoplasma, , Volume: 253, Issue:6	2016
Protective Effects of Molsidomine Against Cisplatin-Induced Nephrotoxicity. Advances in clinical and experimental medicine : official organ Wroclaw Medical University, , Volume: 24, Issue:4
Biochemical and Histological Effects of Thiamine Pyrophosphate against Acetaminophen-Induced Hepatotoxicity. Basic & clinical pharmacology & toxicology, , Volume: 118, Issue:1	2016
Evaluation of the safety, gastroprotective activity and mechanism of action of standardised leaves infusion extract of Copaifera malmei Harms. Journal of ethnopharmacology, , Dec-04, Volume: 175	2015
Protective effect of allicin against gentamicin-induced nephrotoxicity in rats. International immunopharmacology, , Volume: 29, Issue:2	2015
Prophylactic efficacy of S-2(2-aminoethylamino)ethyl phenyl sulfide (DRDE-07) against sulfur mustard induced lung toxicity in mice. Drug and chemical toxicology, , Volume: 39, Issue:2	2016
Toxicological effects, mechanisms, and implied toxicity thresholds in the roots of Vicia faba L. seedlings grown in copper-contaminated soil. Environmental science and pollution research international, , Volume: 22, Issue:18	2015
Nitric oxide ameliorates zinc oxide nanoparticles-induced phytotoxicity in rice seedlings. Journal of hazardous materials, , Oct-30, Volume: 297	2015
The reduced bioavailability of copper by nano-TiO₂ attenuates the toxicity to Microcystis aeruginosa. Environmental science and pollution research international, , Volume: 22, Issue:16	2015
Effects of edaravone on cardiac damage in valproic acid induced toxicity. Annals of clinical and laboratory science, ,Spring, Volume: 45, Issue:2	2015
Adverse events and infectious burden, microbes and temporal outline from immunosuppressive therapy in antineutrophil cytoplasmic antibody-associated vasculitis with native renal function. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 30 Suppl 1	2015
24-epibrassinolide mitigates the adverse effects of manganese induced toxicity through improved antioxidant system and photosynthetic attributes in Brassica juncea. Environmental science and pollution research international, , Volume: 22, Issue:15	2015
Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin. Toxicology and applied pharmacology, , May-15, Volume: 285, Issue:1	2015
Treatment With Dimethyl Fumarate Attenuates Calcineurin Inhibitor-induced Nephrotoxicity. Transplantation, , Volume: 99, Issue:6	2015
Selenium alleviates chromium toxicity by preventing oxidative stress in cabbage (Brassica campestris L. ssp. Pekinensis) leaves. Ecotoxicology and environmental safety, , Volume: 114	2015
A novel strategy for antimicrobial agent: role of exogenous carbon monoxide on suppressing Escherichia coli vitality and toxicity. Pakistan journal of pharmaceutical sciences, , Volume: 28, Issue:1 Suppl	2015
Endoplasmic reticulum stress-activated glycogen synthase kinase 3β aggravates liver inflammation and hepatotoxicity in mice with acute liver failure. Inflammation, , Volume: 38, Issue:3	2015
Evaluation of arsenic trioxide genotoxicity in wheat seedlings using oxidative system and RAPD assays. Environmental science and pollution research international, , Volume: 22, Issue:9	2015
The genotoxic and cytotoxic effects of 1-butyl-3-methylimidazolium chloride in soil on Vicia faba seedlings. Journal of hazardous materials, , Mar-21, Volume: 285	2015
Edaravone ameliorates the adverse effects of valproic acid toxicity in small intestine. Human & experimental toxicology, , Volume: 34, Issue:6	2015
Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. Journal of natural products, , Oct-24, Volume: 77, Issue:10	2014
Ameliorative effect of fisetin on cisplatin-induced nephrotoxicity in rats via modulation of NF-κB activation and antioxidant defence. PloS one, , Volume: 9, Issue:9	2014
Formaldehyde induces bone marrow toxicity in mice by inhibiting peroxiredoxin 2 expression. Molecular medicine reports, , Volume: 10, Issue:4	2014

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Identifying long-range synaptic inputs using genetically encoded labels and volume electron microscopy. Scientific reports, , 06-17, Volume: 12, Issue:1	2022
Clinical efficacy of biomarkers for evaluation of volume status in dialysis patients. Medicine, , Jul-31, Volume: 99, Issue:31	2020
Non-Linear Rituximab Pharmacokinetics and Complex Relationship between Rituximab Concentrations and Anti-Neutrophil Cytoplasmic Antibodies (ANCA) in ANCA-Associated Vasculitis: The RAVE Trial Revisited. Clinical pharmacokinetics, , Volume: 59, Issue:4	2020
Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase I study in healthy volunteers. British journal of clinical pharmacology, , Volume: 85, Issue:4	2019
Myeloperoxidase and Prostate volume: A preliminary study. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie, , Volume: 28, Issue:10	2018
Population Pharmacokinetic Modeling With Enterohepatic Circulation for AZD3241 in Healthy Subjects and Patients With Multiple System Atrophy. Journal of clinical pharmacology, , Volume: 58, Issue:11	2018
NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood, , 05-24, Volume: 131, Issue:21	2018
The chlorinated lipidome originating from myeloperoxidase-derived HOCl targeting plasmalogens: Metabolism, clearance, and biological properties. Archives of biochemistry and biophysics, , 03-01, Volume: 641	2018
Lung Protective Effects of Low-Volume Resuscitation and Pharmacologic Treatment of Swine Subjected to Polytrauma and Hemorrhagic Shock. Inflammation, , Volume: 40, Issue:4	2017
The critical role of myeloperoxidase in Streptococcus pneumoniae clearance and tissue damage during mouse acute otitis media. Innate immunity, , Volume: 23, Issue:3	2017
Myeloperoxidase Attenuates Pathogen Clearance during Plasmodium yoelii Nonlethal Infection. Infection and immunity, , Volume: 85, Issue:1	2017
Early Therapeutic Intervention for Crush Syndrome: Characterization of Intramuscular Administration of Dexamethasone by Pharmacokinetic and Biochemical Parameters in Rats. Biological & pharmaceutical bulletin, , Volume: 39, Issue:9	2016
Development of an Improved Inhalable Powder Formulation of Pirfenidone by Spray-Drying: In Vitro Characterization and Pharmacokinetic Profiling. Pharmaceutical research, , Volume: 33, Issue:6	2016
PHARMACODYNAMICAL EVALUATION OF MATRIX TYPE TRANSDERMAL THERAPEUTIC SYSTEMS CONTAINING CAPTOPRIL. Acta poloniae pharmaceutica, , Volume: 72, Issue:4
Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans. Drug metabolism and disposition: the biological fate of chemicals, , Volume: 44, Issue:2	2016
A patient with diffuse cutaneous systemic sclerosis complicated by antineutrophil-cytoplasmic antibody-associated vasculitis exhibiting honeycomb lung without volume loss. Internal medicine (Tokyo, Japan), , Volume: 53, Issue:7	2014
Liquid chromatography mass spectrometry determination of mocetinostat (MGCD0103) in rat plasma and its application to a pharmacokinetic study. Xenobiotica; the fate of foreign compounds in biological systems, , Volume: 44, Issue:9	2014
Relationships between pharmacokinetics and efficacy of Xie-xin decoction in rats with experimental ulcerative colitis. Journal of ethnopharmacology, , Jun-21, Volume: 148, Issue:1	2013
Dose- and time-dependent effects of lipopolysaccharide on technetium-99-m-labeled diethylene-triamine pentaacetatic acid clearance, respiratory system mechanics and pulmonary inflammation. Experimental biology and medicine (Maywood, N.J.), , Volume: 238, Issue:2	2013
Increased resistance to Staphylococcus aureus endophthalmitis in BALB/c mice: Fas ligand is required for resolution of inflammation but not for bacterial clearance. Infection and immunity, , Volume: 81, Issue:6	2013
Lipoxin A(4) activates alveolar epithelial sodium channel, Na,K-ATPase, and increases alveolar fluid clearance. American journal of respiratory cell and molecular biology, , Volume: 48, Issue:5	2013
Genotype-dependent impairment of hemoglobin clearance increases oxidative and inflammatory response in human diabetic atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology, , Volume: 32, Issue:11	2012
Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice. PloS one, , Volume: 7, Issue:3	2012
Regulation of ENaC-mediated alveolar fluid clearance by insulin via PI3K/Akt pathway in LPS-induced acute lung injury. Respiratory research, , Mar-30, Volume: 13	2012
Gut flora enhance bacterial clearance in lung through toll-like receptors 4. Journal of biomedical science, , Sep-10, Volume: 18	2011
Eicosapentaenoic acid ablates valproate-induced liver oxidative stress and cellular derangement without altering its clearance rate: dynamic synergy and therapeutic utility. Biochimica et biophysica acta, , Volume: 1811, Issue:7-8
Pharmacologic modulation of alveolar liquid clearance in transplanted lungs by phentolamine and FK506. The Annals of thoracic surgery, , Volume: 88, Issue:3	2009
Validation of low-volume 1536-well assay-ready compound plates. Journal of biomolecular screening, , Volume: 14, Issue:5	2009
Method for co-purification of equine neutrophil elastase and myeloperoxidase from a limited blood volume. Research in veterinary science, , Volume: 87, Issue:3	2009
[Effects of conventional mechanical ventilation with low tidal volume on the expression of growth factors and inflammatory mediators in developing porcine lungs]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, , Volume: 10, Issue:4	2008
Evaluation of the pharmacodynamic effects of MGCD0103 from preclinical models to human using a novel HDAC enzyme assay. Clinical cancer research : an official journal of the American Association for Cancer Research, , Jun-01, Volume: 14, Issue:11	2008
The effect of pentoxifylline on the pulmonary response to high tidal volume ventilation in rats. Pulmonary pharmacology & therapeutics, , Volume: 21, Issue:1	2008
Decreased bacterial clearance from the lungs of mice following primary respiratory syncytial virus infection. Journal of medical virology, , Volume: 78, Issue:6	2006
Hyperoxia and tidal volume: Independent and combined effects on neonatal pulmonary inflammation. Biology of the neonate, , Volume: 90, Issue:2	2006
Platelet-activating factor receptor-deficient mice show an unaltered clearance of nontypeable Haemophilus influenzae from their respiratory tract. Shock (Augusta, Ga.), , Volume: 22, Issue:6	2004
Vaccinia virus complement control protein increases early bacterial clearance during experimental peritonitis. Surgical infections, ,Winter, Volume: 4, Issue:4	2003
Protective effect of pentoxifylline on volume-induced lung injury in newborn piglets. Biology of the neonate, , Volume: 86, Issue:1	2004
Deficiency of myeloperoxidase increases infarct volume and nitrotyrosine formation in mouse brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 22, Issue:1	2002
Seasonal differences of peak expiratory flow rate variability and mediators of allergic inflammation in non-atopic adolescents. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, , Volume: 12, Issue:5	2001
Surfactant protein D enhances clearance of influenza A virus from the lung in vivo. Journal of immunology (Baltimore, Md. : 1950), , Nov-15, Volume: 167, Issue:10	2001
Effects of antivenom on Buthus occitanus tunetanus (Bot) scorpion venom pharmacokinetics: towards an optimization of antivenom immunotherapy in a rabbit model. Toxicon : official journal of the International Society on Toxinology, , Volume: 39, Issue:9	2001
The use of platelet density and volume measurements to estimate the severity of pre-eclampsia. European journal of clinical investigation, , Volume: 30, Issue:12	2000
Lung recruitment and lung volume maintenance: a strategy for improving oxygenation and preventing lung injury during both conventional mechanical ventilation and high-frequency oscillation. Intensive care medicine, , Volume: 26, Issue:6	2000
Innate lung defenses and compromised Pseudomonas aeruginosa clearance in the malnourished mouse model of respiratory infections in cystic fibrosis. Infection and immunity, , Volume: 68, Issue:4	2000
P-selectin antibody reduces hemorrhage and infarct volume resulting from MCA occlusion in the rat. Journal of the neurological sciences, , Nov-26, Volume: 161, Issue:1	1998
High-volume continuous hemofiltration during cardiopulmonary bypass attenuates pulmonary dysfunction in neonatal lambs after deep hypothermic circulatory arrest. Circulation, , Nov-10, Volume: 98, Issue:19 Suppl	1998
Synthetic peptide derived from the Bordetella pertussis bacterium reduces infarct volume after transient middle cerebral artery occlusion in the rat. Neurology, , Volume: 46, Issue:5	1996
Neutralization of macrophage inflammatory protein-2 attenuates neutrophil recruitment and bacterial clearance in murine Klebsiella pneumonia. The Journal of infectious diseases, , Volume: 173, Issue:1	1996
Tidal flow volume loops and inflammatory indicators in small children. International archives of allergy and immunology, , Volume: 107, Issue:1-3
Eosinophil cationic protein and tidal flow volume loops in children 0-2 years of age. The European respiratory journal, , Volume: 8, Issue:7	1995
Flow cytometric analysis of macrophage heterogeneity and differentiation: utilization of electronic cell volume and fluorescent substrates corresponding to common macrophage markers. Journal of the Reticuloendothelial Society, , Volume: 32, Issue:4	1982
Identification of proteins in small tear volumes with and without size exclusion HPLC fractionation. Current eye research, , Volume: 7, Issue:2	1988
Age-dependent pulmonary clearance of Pseudomonas aeruginosa in a mouse model: diminished migration of polymorphonuclear leukocytes to N-formyl-methionyl-leucyl-phenylalanine. Infection and immunity, , Volume: 60, Issue:4	1992

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GYY4137, a hydrogen sulfide donor, protects against endothelial dysfunction in porcine coronary arteries exposed to myeloperoxidase and hypochlorous acid. Vascular pharmacology, , Volume: 152	2023
A novel nano-formulation of olmesartan medoxomil with improved delivery and efficacy in the treatment of indomethacin-induced duodenitis in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, , Volume: 56	2023
Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease. American journal of physiology. Gastrointestinal and liver physiology, , Oct-01, Volume: 323, Issue:4	2022
Melatonin interferes with COVID-19 at several distinct ROS-related steps. Journal of inorganic biochemistry, , Volume: 223	2021
Magnetoresponsive nanozyme: magnetic stimulation on the nanozyme activity of iron oxide nanoparticles. Science China. Life sciences, , Volume: 65, Issue:1	2022
Anti-Inflammatory Effects of Rosmarinic Acid-Loaded Nanovesicles in Acute Colitis through Modulation of NLRP3 Inflammasome. Biomolecules, , 01-26, Volume: 11, Issue:2	2021
Anti-inflammatory and Antioxidant Activity of Nanoencapsulated Curcuminoids Extracted from Curcuma longa L. in a Model of Cutaneous Inflammation. Inflammation, , Volume: 44, Issue:2	2021
Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO). Bioorganic & medicinal chemistry, , 06-15, Volume: 28, Issue:12	2020
Antagonism or synergism? Responses of Hydrocharis dubia (Bl.) Backer to linear alkylbenzene sulfonate, naphthalene and their joint exposure. Ecotoxicology and environmental safety, , Sep-01, Volume: 200	2020
Dielectric barrier atmospheric cold plasma applied on camu-camu juice processing: Effect of the excitation frequency. Food research international (Ottawa, Ont.), , Volume: 131	2020
Emerging perspectives on cytoglobin, beyond NO dioxygenase and peroxidase. Redox biology, , Volume: 32	2020
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology, , Volume: 96, Issue:5	2019
A three-pronged formulation approach to improve oral bioavailability and therapeutic efficacy of two lipophilic drugs with gastric lability. Drug delivery and translational research, , Volume: 9, Issue:4	2019
Nanocurcumin ameliorates Staphylococcus aureus-induced mastitis in mouse by suppressing NF‑κB signaling and inflammation. International immunopharmacology, , Volume: 65	2018
EDTA and organic acids assisted phytoextraction of Cd and Zn from a smelter contaminated soil by potherb mustard (Brassica juncea, Coss) and evaluation of its bioindicators. Ecotoxicology and environmental safety, , Jan-15, Volume: 167	2019
In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. Bioorganic & medicinal chemistry, , 09-15, Volume: 26, Issue:17	2018
Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor. The Journal of pharmacology and experimental therapeutics, , Volume: 367, Issue:1	2018
Population Pharmacokinetic Modeling With Enterohepatic Circulation for AZD3241 in Healthy Subjects and Patients With Multiple System Atrophy. Journal of clinical pharmacology, , Volume: 58, Issue:11	2018
Myeloperoxidase in Hypertensive Disorders of Pregnancy and Its Relation With Nitric Oxide. Hypertension (Dallas, Tex. : 1979), , Volume: 69, Issue:6	2017
Protective effects of tranilast on experimental colitis in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 90	2017
Regulation of the nitric oxide oxidase activity of myeloperoxidase by pharmacological agents. Biochemical pharmacology, , 07-01, Volume: 135	2017
Altered systemic bioavailability and organ distribution of azathioprine in methotrexate-induced intestinal mucositis in rats. Indian journal of pharmacology, , Volume: 48, Issue:3
Relative Inhibitions of 5-Lipoxygenase and Myeloperoxidase and Free-Radical Scavenging Activities of Daidzein, Dihydrodaidzein, and Equol. Journal of medicinal food, , Volume: 19, Issue:6	2016
Diclofenac acid nanocrystals as an effective strategy to reduce in vivo skin inflammation by improving dermal drug bioavailability. Colloids and surfaces. B, Biointerfaces, , Jul-01, Volume: 143	2016
Development and performance evaluation of novel nanoparticles of a grafted copolymer loaded with curcumin. International journal of biological macromolecules, , Volume: 86	2016
Small bowel protection against NSAID-injury in rats: Effect of rifaximin, a poorly absorbed, GI targeted, antibiotic. Pharmacological research, , Volume: 104	2016
The DyP-type peroxidase DtpA is a Tat-substrate required for GlxA maturation and morphogenesis in Streptomyces. Open biology, , Volume: 6, Issue:1	2016
Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans. Drug metabolism and disposition: the biological fate of chemicals, , Volume: 44, Issue:2	2016
The Effect of a Selective Inhibitor of Phosphodiesterase-9 on Oxidative Stress, Inflammation and Cytotoxicity in Neutrophils from Patients with Sickle Cell Anaemia. Basic & clinical pharmacology & toxicology, , Volume: 118, Issue:4	2016
The reduced bioavailability of copper by nano-TiO₂ attenuates the toxicity to Microcystis aeruginosa. Environmental science and pollution research international, , Volume: 22, Issue:16	2015
Levosimendan displays anti-inflammatory effects and decreases MPO bioavailability in patients with severe heart failure. Scientific reports, , Apr-13, Volume: 5	2015
Colorimetric peroxidase mimetic assay for uranyl detection in sea water. ACS applied materials & interfaces, , Mar-04, Volume: 7, Issue:8	2015
Quercetin bioavailability is associated with inadequate plasma vitamin C status and greater plasma endotoxin in adults. Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 30, Issue:11-12
Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain. Journal of neuroinflammation, , Aug-28, Volume: 11	2014
Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial. BMC complementary and alternative medicine, , May-17, Volume: 14	2014
Inducible nitric oxide synthase inhibition reverses pulmonary arterial dysfunction in lung transplantation. Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 63, Issue:8	2014
Mechanism and regulation of peroxidase-catalyzed nitric oxide consumption in physiological fluids: critical protective actions of ascorbate and thiocyanate. Free radical biology & medicine, , Volume: 72	2014
Liquid chromatography mass spectrometry determination of mocetinostat (MGCD0103) in rat plasma and its application to a pharmacokinetic study. Xenobiotica; the fate of foreign compounds in biological systems, , Volume: 44, Issue:9	2014
Myeloperoxidase upregulates endothelin receptor type B expression. Journal of molecular and cellular cardiology, , Volume: 69	2014
The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction. The Biochemical journal, , Jan-01, Volume: 457, Issue:1	2014
Speciation and bioavailability of dissolved copper in different freshwaters: comparison of modelling, biological and chemical responses in aquatic mosses and gammarids. The Science of the total environment, , May-01, Volume: 452-453	2013
Bioavailability and oxidative stress of cadmium to Corbicula fluminea. Environmental science. Processes & impacts, , Volume: 15, Issue:4	2013
Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors. Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1	2013
6b,11b-Dihydroxy-6b,11b-dihydro-7H-indeno[1,2-b]naphtho[2,1-d]furan-7-one (DHFO), a small molecule targeting NF-κB, demonstrates therapeutic potential in immunopathogenic chronic inflammatory conditions. International immunopharmacology, , Volume: 15, Issue:1	2013
Accumulation of heavy metals and antioxidant responses in Vicia faba plants grown on monometallic contaminated soil. Environmental science and pollution research international, , Volume: 20, Issue:2	2013
Nitrite reduces ischemia/reperfusion-induced muscle damage and improves survival rates in rat crush injury model. The journal of trauma and acute care surgery, , Volume: 72, Issue:6	2012
Activation of peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) prevents endothelial dysfunction in type 1 diabetic rats. Free radical biology & medicine, , Aug-15, Volume: 53, Issue:4	2012
Nitro-oxidative stress biomarkers in active and inactive men. International journal of sports medicine, , Volume: 33, Issue:4	2012
Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis. Journal of Crohn's & colitis, , Volume: 6, Issue:2	2012
The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat. Biomaterials, , Volume: 33, Issue:10	2012
Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase. Circulation, , Dec-13, Volume: 124, Issue:24	2011
Myeloperoxidase deficiency preserves vasomotor function in humans. European heart journal, , Volume: 33, Issue:13	2012
Systemic inflammation is linked to low arginine and high ADMA plasma levels resulting in an unfavourable NOS substrate-to-inhibitor ratio: the Hoorn Study. Clinical science (London, England : 1979), , Volume: 121, Issue:2	2011
Amelioration of experimental colitis by a novel nanoselenium-silymarin mixture. Toxicology mechanisms and methods, , Volume: 21, Issue:3	2011
Discovery of (2-fluoro-benzyl)-(2-methyl-2-phenethyl-2H-chromen-6-yl)-amine (KRH-102140) as an orally active 5-lipoxygenase inhibitor with activity in murine inflammation models. Pharmacology, , Volume: 87, Issue:1-2	2011
Mobile phone radiation-induced free radical damage in the liver is inhibited by the antioxidants N-acetyl cysteine and epigallocatechin-gallate. International journal of radiation biology, , Volume: 86, Issue:11	2010
The role of erythropoietin in the protection of gastric mucosa from indometacin-induced gastric injury and its relationship with oxidant and antioxidant parameters in rats. The Journal of pharmacy and pharmacology, , Volume: 62, Issue:1	2010
A case of infection-associated antiproteinase-3-negative cytoplasmic antineutrophil cytoplasmic antibody pauci-immune focal necrotizing glomerulonephritis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 25, Issue:9	2010
Regular exercise training prevents aortic valve disease in low-density lipoprotein-receptor-deficient mice. Circulation, , Feb-16, Volume: 121, Issue:6	2010
Myeloperoxidase-dependent oxidative metabolism of nitric oxide in the cystic fibrosis airway. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, , Volume: 9, Issue:2	2010
Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults. Hypertension (Dallas, Tex. : 1979), , Volume: 55, Issue:2	2010
[Research advances in plant lead tolerance and detoxification mechanism]. Ying yong sheng tai xue bao = The journal of applied ecology, , Volume: 20, Issue:3	2009
Myeloperoxidase: a useful biomarker for cardiovascular disease risk stratification? Clinical chemistry, , Volume: 55, Issue:8	2009
Ibuprofen-arginine generates nitric oxide and has enhanced anti-inflammatory effects. Pharmacological research, , Volume: 60, Issue:4	2009
Role of oxidative and nitrosative stress biomarkers in chronic heart failure. Frontiers in bioscience (Landmark edition), , 01-01, Volume: 14, Issue:6	2009
Copper toxicity influence on antioxidant enzymes activity in tomato plants and role of arbuscular mycorrhizal fungus Glomus etunicatum in the tolerance of toxicity. Pakistan journal of biological sciences : PJBS, , Jun-15, Volume: 10, Issue:12	2007
Liberation of vessel adherent myeloperoxidase by enoxaparin improves endothelial function. International journal of cardiology, , Apr-01, Volume: 140, Issue:1	2010
New coumarin-based anti-inflammatory drug: putative antagonist of the integrins alphaLbeta2 and alphaMbeta2. The Journal of pharmacy and pharmacology, , Volume: 60, Issue:11	2008
Bivalirudin decreases NO bioavailability by vascular immobilization of myeloperoxidase. The Journal of pharmacology and experimental therapeutics, , Volume: 327, Issue:2	2008
Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor. Journal of medicinal chemistry, , Jul-24, Volume: 51, Issue:14	2008
The interaction between coronary endothelial dysfunction, local oxidative stress, and endogenous nitric oxide in humans. Hypertension (Dallas, Tex. : 1979), , Volume: 51, Issue:1	2008
Colon-specific delivery of 5-aminosalicylic acid from chitosan-Ca-alginate microparticles. International journal of pharmaceutics, , Sep-05, Volume: 342, Issue:1-2	2007
Betanin inhibits the myeloperoxidase/nitrite-induced oxidation of human low-density lipoproteins. Free radical research, , Volume: 41, Issue:3	2007
Coronary plaque injury triggers neutrophil activation in patients with coronary artery disease. Free radical biology & medicine, , Feb-15, Volume: 42, Issue:4	2007
Inhaled nitric oxide attenuates reperfusion inflammatory responses in humans. Anesthesiology, , Volume: 106, Issue:2	2007
Myeloperoxidase-mediated LDL oxidation and endothelial cell toxicity of oxidized LDL: attenuation by (-)-epicatechin. Free radical research, , Volume: 40, Issue:10	2006
Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase. Circulation, , Apr-18, Volume: 113, Issue:15	2006
Endurance training reduces circulating asymmetric dimethylarginine and myeloperoxidase levels in persons at risk of coronary events. Thrombosis and haemostasis, , Volume: 94, Issue:6	2005
Antioxidant defense system during endometrial receptivity in the guinea pig: effect of ormeloxifene, a selective estrogen receptor modulator. The Journal of endocrinology, , Volume: 188, Issue:1	2006
Toxicity assessment of two soils from Jales mine (Portugal) using plants: growth and biochemical parameters. Archives of environmental contamination and toxicology, , Volume: 50, Issue:2	2006
Pharmacological profile of CR3465, a new leukotriene CysLT1 receptor antagonist with broad anti-inflammatory activity. European journal of pharmacology, , Nov-19, Volume: 504, Issue:3	2004
Leukocyte-derived myeloperoxidase amplifies high-glucose--induced endothelial dysfunction through interaction with high-glucose--stimulated, vascular non--leukocyte-derived reactive oxygen species. Diabetes, , Volume: 53, Issue:11	2004
Membrane permeability and antipyrine absorption in a rat model of ischemic colitis. International journal of pharmaceutics, , Nov-22, Volume: 286, Issue:1-2	2004
Serum myeloperoxidase levels independently predict endothelial dysfunction in humans. Circulation, , Aug-31, Volume: 110, Issue:9	2004
Myeloperoxidase enhances nitric oxide catabolism during myocardial ischemia and reperfusion. Free radical biology & medicine, , Sep-15, Volume: 37, Issue:6	2004
Albumin mediates the transcytosis of myeloperoxidase by means of caveolae in endothelial cells. Proceedings of the National Academy of Sciences of the United States of America, , May-18, Volume: 101, Issue:20	2004
The role of oxidative stress-altered lipoprotein structure and function and microinflammation on cardiovascular risk in patients with minor renal dysfunction. Journal of the American Society of Nephrology : JASN, , Volume: 15, Issue:3	2004
Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback inhibition. Proceedings of the National Academy of Sciences of the United States of America, , Dec-09, Volume: 100, Issue:25	2003
Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science (New York, N.Y.), , Jun-28, Volume: 296, Issue:5577	2002
Leaf biochemical parameters in Avicennia marina (Forsk.) Vierh as potential biomarkers of heavy metal stress in estuarine ecosystems. Marine pollution bulletin, , Volume: 44, Issue:3	2002
Effects of antivenom on Buthus occitanus tunetanus (Bot) scorpion venom pharmacokinetics: towards an optimization of antivenom immunotherapy in a rabbit model. Toxicon : official journal of the International Society on Toxinology, , Volume: 39, Issue:9	2001
Sulfinamide formation following peroxidatic metabolism of N-acetylbenzidine. Chemical research in toxicology, , Volume: 13, Issue:2	2000
The effect of an inhibitor of matrix metalloproteinases on colonic inflammation in a trinitrobenzenesulphonic acid rat model of inflammatory bowel disease. Alimentary pharmacology & therapeutics, , Volume: 13, Issue:11	1999
Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P. Proceedings of the National Academy of Sciences of the United States of America, , Sep-28, Volume: 96, Issue:20	1999
Beneficial effect of raxofelast, an hydrophilic vitamin E analogue, in the rat heart after ischemia and reperfusion injury. Journal of molecular and cellular cardiology, , Volume: 30, Issue:8	1998
Regulation of intracellular polymorphonuclear leukocyte Fc receptors by lipopolysaccharide. Cellular immunology, , Volume: 157, Issue:2	1994
Topical anticolitic efficacy and selectivity of the glucocorticoid budesonide in a new model of acetic acid-induced acute colitis in the rat. Alimentary pharmacology & therapeutics, , Volume: 8, Issue:4	1994

Article	Year
RLS-0071 Moderated Elevated Myeloperoxidase Level and Activity in an Asymptomatic Subject in Clinical Trial RLS-0071-101. The American journal of case reports, , May-26, Volume: 24	2023
Cerium and samarium blocked antioxidant enzymes in wheat plants. Scientific reports, , 05-22, Volume: 13, Issue:1	2023
Equine Muscle Derived Mesenchymal Stem Cells Loaded with Water-Soluble Curcumin: Modulation of Neutrophil Activation and Enhanced Protection against Intracellular Oxidative Attack. International journal of molecular sciences, , Jan-05, Volume: 24, Issue:2	2023
Plasma exchange and glucocorticoids to delay death or end-stage renal disease in anti-neutrophil cytoplasm antibody-associated vasculitis: PEXIVAS non-inferiority factorial RCT. Health technology assessment (Winchester, England), , Volume: 26, Issue:38	2022
Moderate intestinal immunopathology after acute oral infection with Toxoplasma gondii oocysts is associated with expressive levels of serotonin. Life sciences, , Nov-15, Volume: 309	2022
Peroxidase-Mimetic Copper-Doped Carbon-Dots for Oxidative Stress-Mediated Broad-Spectrum and Efficient Antibacterial Activity. Chemistry (Weinheim an der Bergstrasse, Germany), , Mar-07, Volume: 28, Issue:14	2022
Plasma creatinine below limit of quantification in a patient with acute kidney injury. Clinica chimica acta; international journal of clinical chemistry, , Jan-01, Volume: 524	2022
Toxicity and tissue accumulation characteristics of the herbicide pendimethalin under silicon application in ginger (Zingiber officinale Roscoe). Environmental science and pollution research international, , Volume: 29, Issue:17	2022
Chlorogenic acid reduces inflammation in murine model of acute pancreatitis. Pharmacological reports : PR, , Volume: 73, Issue:5	2021
Vitamin C, Hydrocortisone, and the Combination Thereof Significantly Inhibited Two of Nine Inflammatory Markers Induced by Escherichia Coli But Not by Staphylococcus Aureus - When Incubated in Human Whole Blood. Shock (Augusta, Ga.), , 01-01, Volume: 57, Issue:1	2022
Highly Efficient Activatable MRI Probe to Sense Myeloperoxidase Activity. Journal of medicinal chemistry, , 05-13, Volume: 64, Issue:9	2021
Gegen Qinlian decoction relieved DSS-induced ulcerative colitis in mice by modulating Th17/Treg cell homeostasis via suppressing IL-6/JAK2/STAT3 signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 84	2021
Polyphenol oxidase dominates the conversions of flavonol glycosides in tea leaves. Food chemistry, , Mar-01, Volume: 339	2021
Early Clinical Experience With AZD4831, A Novel Myeloperoxidase Inhibitor, Developed for Patients With Heart Failure With Preserved Ejection Fraction. Clinical and translational science, , Volume: 14, Issue:3	2021
Association of Cigarette Smoking With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. JAMA internal medicine, , 06-01, Volume: 180, Issue:6	2020
Rationale of concomitant cyclophosphamide for remission-induction in patients with antineutrophil cytoplasmic antibody-associated vasculitis: A propensity score-matched analysis of two nationwide prospective cohort studies. Modern rheumatology, , Volume: 31, Issue:1	2021
Clinical Effect of Alpha-1 Antitrypsin Deficiency in Antineutrophil Cytoplasmic Antibody-associated Vasculitis: Results from a French Retrospective Monocentric Cohort. The Journal of rheumatology, , Volume: 46, Issue:11	2019
Effect of selective versus nonselective cyclooxygenase inhibitors on gastric ulceration scores and intestinal inflammation in horses. Veterinary surgery : VS, , Volume: 47, Issue:6	2018
Detoxification of mercury in soil by selenite and related mechanisms. Ecotoxicology and environmental safety, , Sep-15, Volume: 159	2018
Tocoyena sellowiana extract decreases bone loss in an experimental model of periodontitis in rats: Putative role for cyclooxygenase-2 and IL-1? inhibition. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 98	2018
Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice. PloS one, , Volume: 13, Issue:3	2018
Chitosan nanoparticles having higher degree of acetylation induce resistance against pearl millet downy mildew through nitric oxide generation. Scientific reports, , 02-06, Volume: 8, Issue:1	2018
Remote myocardial injury: the protective role of fluoxetine. Canadian journal of physiology and pharmacology, , Volume: 96, Issue:4	2018
Prophylactic and therapeutic effect of Punica granatum in trinitrobenzene sulfonic acid induced inflammation in rats. Pakistan journal of pharmaceutical sciences, , Volume: 30, Issue:1	2017
5-ASA-loaded SiO2 nanoparticles-a novel drug delivery system targeting therapy on ulcerative colitis in mice. Molecular medicine reports, , Volume: 15, Issue:3	2017
Differential Effectiveness of Clinically-Relevant Analgesics in a Rat Model of Chemotherapy-Induced Mucositis. PloS one, , Volume: 11, Issue:7	2016
Phosalone-induced inflammation and oxidative stress in the colon: Evaluation and treatment. World journal of gastroenterology, , Jun-07, Volume: 22, Issue:21	2016
Ginkgolide B functions as a determinant constituent of Ginkgolides in alleviating lipopolysaccharide-induced lung injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 81	2016
Recombinant human brain natriuretic peptide attenuates trauma-/haemorrhagic shock-induced acute lung injury through inhibiting oxidative stress and the NF-κB-dependent inflammatory/MMP-9 pathway. International journal of experimental pathology, , Volume: 96, Issue:6	2015
A new animal model of intestinal mucositis induced by the combination of irinotecan and 5-fluorouracil in mice. Cancer chemotherapy and pharmacology, , Volume: 77, Issue:2	2016
Neutrophil-derived myeloperoxidase promotes atherogenesis and neointima formation in mice. International journal of cardiology, , Feb-01, Volume: 204	2016
Metabolic changes in rats after intragastric administration of MGCD0103 (Mocetinostat), a HDAC class I inhibitor. International journal of clinical and experimental pathology, , Volume: 8, Issue:8	2015
Effects of arachidonic acid intake on inflammatory reactions in dextran sodium sulphate-induced colitis in rats. The British journal of nutrition, , Sep-14, Volume: 114, Issue:5	2015
Toxicological effects, mechanisms, and implied toxicity thresholds in the roots of Vicia faba L. seedlings grown in copper-contaminated soil. Environmental science and pollution research international, , Volume: 22, Issue:18	2015
A modified "double-hit" induced acute lung injury model in rats and protective effects of tetramethylpyrazine on the injury via Rho/ROCK pathway. International journal of clinical and experimental pathology, , Volume: 8, Issue:5	2015
Molecular, Biochemical and Ultrastructural Changes Induced by Pb Toxicity in Seedlings of Theobroma cacao L. PloS one, , Volume: 10, Issue:7	2015
Effects of fenugreek (Trigonella foenum graecum) on gilthead seabream (Sparus aurata L.) immune status and growth performance. Fish & shellfish immunology, , Volume: 45, Issue:2	2015
Natural antioxidant betanin protects rats from paraquat-induced acute lung injury interstitial pneumonia. BioMed research international, , Volume: 2015	2015
Changes in soil microbial functional diversity and biochemical characteristics of tree peony with amendment of sewage sludge compost. Environmental science and pollution research international, , Volume: 22, Issue:15	2015
Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing. Nuclear medicine and biology, , Volume: 42, Issue:6	2015
Oxidative status imbalance in patients with metabolic syndrome: role of the myeloperoxidase/hydrogen peroxide axis. Oxidative medicine and cellular longevity, , Volume: 2014	2014
Intricacies of redoxome function demonstrated with a simple in vitro chemiluminescence method, with special reference to vitamin B12 as antioxidant. Scandinavian journal of immunology, , Volume: 80, Issue:6	2014
Rutin has intestinal antiinflammatory effects in the CD4+ CD62L+ T cell transfer model of colitis. Pharmacological research, , Volume: 90	2014
A novel zebrafish model to provide mechanistic insights into the inflammatory events in carrageenan-induced abdominal edema. PloS one, , Volume: 9, Issue:8	2014
Chemotherapy-associated steatohepatitis induced by irinotecan: a novel animal model. Cancer chemotherapy and pharmacology, , Volume: 74, Issue:4	2014
The effect of etoricoxib on kidney ischemia-reperfusion injury in rats: a biochemical and immunohistochemical assessment. International immunopharmacology, , Volume: 23, Issue:1	2014
Repeated daily dosing with sildenafil provides sustained protection from endothelial dysfunction caused by ischemia and reperfusion: a human in vivo study. American journal of physiology. Heart and circulatory physiology, , Sep-15, Volume: 307, Issue:6	2014
Effects of enoxaparin on myeloperoxidase release during hemodialysis. Hemodialysis international. International Symposium on Home Hemodialysis, , Volume: 18, Issue:4	2014
Sulfated caffeic acid dehydropolymer attenuates elastase and cigarette smoke extract-induced emphysema in rats: sustained activity and a need of pulmonary delivery. Lung, , Volume: 192, Issue:4	2014
Evaluation of the pharmacological properties of salicylic acid-derivative organoselenium: 2-hydroxy-5-selenocyanatobenzoic acid as an anti-inflammatory and antinociceptive compound. Pharmacology, biochemistry, and behavior, , Volume: 118	2014
Soybean peroxidase-mediated degradation of an azo dye- a detailed mechanistic study. BMC biochemistry, , Dec-05, Volume: 14	2013
Peroxidase-like activity of Fe3O4@carbon nanoparticles enhances ascorbic acid-induced oxidative stress and selective damage to PC-3 prostate cancer cells. ACS applied materials & interfaces, , Dec-26, Volume: 5, Issue:24	2013
[Therapeutic effects of muscovite on ulcerative colitis in rats]. Zhonghua yi xue za zhi, , Jul-23, Volume: 93, Issue:28	2013
Pentoxifylline protects the small intestine after severe ischemia and reperfusion. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, , Volume: 11, Issue:3	2013
Protective effect of sevoflurane on hepatic ischaemia/reperfusion injury in the rat: A dose-response study. European journal of anaesthesiology, , Volume: 30, Issue:10	2013
Investigation of neurotoxic and immunotoxic effects of some plant growth regulators at subacute and subchronic applications on rats. Toxicology and industrial health, , Volume: 31, Issue:12	2015
5-Aminolevulinic acid ameliorates cadmium-induced morphological, biochemical, and ultrastructural changes in seedlings of oilseed rape. Environmental science and pollution research international, , Volume: 20, Issue:10	2013
Relationships between pharmacokinetics and efficacy of Xie-xin decoction in rats with experimental ulcerative colitis. Journal of ethnopharmacology, , Jun-21, Volume: 148, Issue:1	2013
Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity. Journal of drug targeting, , Volume: 21, Issue:5	2013
Systems pharmacology modeling of drug-induced modulation of thyroid hormones in dogs and translation to human. Pharmaceutical research, , Volume: 30, Issue:6	2013
Maintenance of α(1)-antitrypsin activity by means of co-application of hypochlorous acid-scavengers in vitro and in the supernatant of polymorphonuclear leukocytes: as a basis for a new drug delivery approach. Biomatter, , Volume: 2, Issue:1
5-Aminolevolinic acid mitigates the cadmium-induced changes in Brassica napus as revealed by the biochemical and ultra-structural evaluation of roots. Ecotoxicology and environmental safety, , Volume: 92	2013
Bioavailability and oxidative stress of cadmium to Corbicula fluminea. Environmental science. Processes & impacts, , Volume: 15, Issue:4	2013
High-dose chlorogenic acid induces inflammation reactions and oxidative stress injury in rats without implication of mast cell degranulation. Journal of ethnopharmacology, , May-02, Volume: 147, Issue:1	2013
Efficiency of biodegradable EDDS, NTA and APAM on enhancing the phytoextraction of cadmium by Siegesbeckia orientalis L. grown in Cd-contaminated soils. Chemosphere, , Volume: 91, Issue:9	2013
A comparative study of pentoxifylline effects in adult and aged rats submitted to lung dysfunction by thermal injury. Acta cirurgica brasileira, , Volume: 28, Issue:2	2013
The comparision of Coprinus cinereus peroxidase enzyme and TiO2 catalyst for phenol removal. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, , Volume: 48, Issue:3	2013
The novel orally active guanylhydrazone CPSI-2364 prevents postoperative ileus in mice independently of anti-inflammatory vagus nerve signaling. Langenbeck's archives of surgery, , Volume: 397, Issue:7	2012
Potential role of a quetiapine metabolite in quetiapine-induced neutropenia and agranulocytosis. Chemical research in toxicology, , May-21, Volume: 25, Issue:5	2012
Hepatoprotective effect of Filipendula hexapetala Gilib. (Rosaceae) in carbon tetrachloride-induced hepatotoxicity in rats. Phytotherapy research : PTR, , Volume: 26, Issue:7	2012
Protection of ultra-filtration extract from Danggui Buxue Decoction on oxidative damage in cardiomyocytes of neonatal rats and its mechanism. Chinese journal of integrative medicine, , Volume: 17, Issue:11	2011
Suppression of NF-κB pathway by crocetin contributes to attenuation of lipopolysaccharide-induced acute lung injury in mice. European journal of pharmacology, , Jan-15, Volume: 674, Issue:2-3	2012
Oxidative biomarkers in leaf tissue of barley seedlings in response to aluminum stress. Ecotoxicology and environmental safety, , Volume: 75, Issue:1	2012
Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease. Biochemical pharmacology, , Oct-01, Volume: 82, Issue:7	2011
Toxicity profile of solvents by aspiration approach for topical agent delivery to respiratory tract epithelium. International journal of toxicology, , Volume: 30, Issue:3	2011
Magnesium sulfate mitigates lung injury induced by bilateral lower limb ischemia-reperfusion in rats. The Journal of surgical research, , Volume: 171, Issue:1	2011
Myeloperoxidase-mediated bioactivation of 5-hydroxythiabendazole: a possible mechanism of thiabendazole toxicity. Toxicology in vitro : an international journal published in association with BIBRA, , Volume: 25, Issue:5	2011
SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. British journal of clinical pharmacology, , Volume: 72, Issue:2	2011
Degradation of pentachlorophenol by a novel peroxidase-catalyzed process in the presence of reduced nicotinamide adenine dinucleotide. Chemosphere, , Volume: 83, Issue:2	2011
Evaluation of anti-inflammatory and antinociceptive effects of D-002 (beeswax alcohols). Journal of natural medicines, , Volume: 65, Issue:2	2011
Neurotoxic and immunotoxic effects of fenthion and omethoate on frogs at acute exposure. Toxicology and industrial health, , Volume: 27, Issue:4	2011
Evaluation of neurotoxic and immunotoxic effects of trichloroacetic acid on rats. Toxicology and industrial health, , Volume: 26, Issue:10	2010
The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis. British journal of pharmacology, , Volume: 160, Issue:3	2010
Pentoxifylline inhibits intercellular adhesion molecule-1 (ICAM-1) and lung injury in experimental phosgene-exposure rats. Inhalation toxicology, , Volume: 22, Issue:11	2010
Adaptation of rat gastric tissue against indomethacin toxicity. Chemico-biological interactions, , Jun-07, Volume: 186, Issue:1	2010
Mycophenolate mofetil for induction and maintenance of remission in microscopic polyangiitis with mild to moderate renal involvement--a prospective, open-label pilot trial. Clinical journal of the American Society of Nephrology : CJASN, , Volume: 5, Issue:3	2010
Improvement of rapidly progressive lupus nephritis associated MPO-ANCA with tacrolimus. Modern rheumatology, , Volume: 20, Issue:3	2010
Action of a Novel PDE4 inhibitor ZL-n-91 on lipopolysaccharide-induced acute lung injury. International immunopharmacology, , Volume: 10, Issue:4	2010
[Case of microscopic polyangiitis presenting initially as prostatic vasculitis]. Nihon Jinzo Gakkai shi, , Volume: 51, Issue:8	2009
Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations. Biochemical pharmacology, , Apr-15, Volume: 79, Issue:8	2010
Lung inflammation is associated with reduced pulmonary nucleotide excision repair in vivo. Mutagenesis, , Volume: 25, Issue:1	2010
Zl-n-91, a selective phosphodiesterase 4 inhibitor, suppresses inflammatory response in a COPD-like rat model. International immunopharmacology, , Volume: 10, Issue:2	2010
A long-term follow-up of serum myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) in patients with Graves disease treated with propylthiouracil. Endocrine journal, , Volume: 57, Issue:1	2010
Non-alcoholic steatohepatitis induces non-fibrosis-related portal hypertension associated with splanchnic vasodilation and signs of a hyperdynamic circulation in vitro and in vivo in a rat model. Liver international : official journal of the International Association for the Study of the Liver, , Volume: 30, Issue:3	2010
Heavy metal uptake and its effect on macronutrients, chlorophyll, protein, and peroxidase activity of Paspalum distichum grown on sludge-dosed soils. Heavy metal uptake and its effect on P. distichum. Environmental monitoring and assessment, , Volume: 169, Issue:1-4	2010
Neuroprotective effect of melatonin on experimental peripheral nerve injury: an electron microscopic and biochemical study. Central European neurosurgery, , Volume: 70, Issue:3	2009
Sono-enhanced degradation of dye pollutants with the use of H2O2 activated by Fe3O4 magnetic nanoparticles as peroxidase mimetic. Ultrasonics sonochemistry, , Volume: 17, Issue:1	2010
Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats. Cell transplantation, , Volume: 18, Issue:8	2009
Neurotoxic and immunotoxic effects of Indole-3-butyric acid on rats at subacute and subchronic exposure. Neurotoxicology, , Volume: 30, Issue:3	2009
Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats. European journal of pharmacology, , Mar-15, Volume: 606, Issue:1-3	2009

Article	Year
The value of serum Lp-PLA2 combined with MPO in the diagnosis of cerebral infarction caused by large artery atherosclerosis. Clinical neurology and neurosurgery, , Volume: 232	2023
Antieosinophil Antibodies Alone or in Combination with Antineutrophil Cytoplasmic Antibodies (ANCA) Detected in Different Autoimmune Conditions. Journal of immunology research, , Volume: 2023	2023
Clinical Evaluation of High-Resolution MRI Combined With DWI in Identifying Vulnerable Carotid Plaque. The neurologist, , Jan-01, Volume: 28, Issue:1	2023
Immunomodulatory dose of clindamycin in combination with ceftriaxone improves survival and prevents organ damage in murine polymicrobial sepsis. Naunyn-Schmiedeberg's archives of pharmacology, , Volume: 393, Issue:9	2020
Effects of mesalazine combined with bifid triple viable on intestinal flora, immunoglobulin and levels of cal, MMP-9, and MPO in feces of patients with ulcerative colitis. European review for medical and pharmacological sciences, , Volume: 24, Issue:2	2020
Phase I/II study of mocetinostat in combination with gemcitabine for patients with advanced pancreatic cancer and other advanced solid tumors. Cancer chemotherapy and pharmacology, , Volume: 81, Issue:2	2018
Mocetinostat combined with gemcitabine for the treatment of leiomyosarcoma: Preclinical correlates. PloS one, , Volume: 12, Issue:11	2017
Neutrophil extracellular traps induce IL-1β production by macrophages in combination with lipopolysaccharide. International journal of molecular medicine, , Volume: 39, Issue:3	2017
Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats. Indian journal of pharmacology, , Volume: 46, Issue:6
Impact of the neutrophil response to granulocyte colony-stimulating factor on the risk of hemorrhage when used in combination with tissue plasminogen activator during the acute phase of experimental stroke. Journal of neuroinflammation, , May-27, Volume: 11	2014
Cutting needle biopsy combined with immunohistochemical study of myeloperoxidase for the diagnosis of histiocytic necrotizing lymphadenitis. Acta oto-laryngologica, , Volume: 133, Issue:12	2013
Comparative evaluation of different doses of PPAR-γ agonist alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats. Pharmacological reports : PR, , Volume: 65, Issue:4	2013
Amaranthus roxburghianus root extract in combination with piperine as a potential treatment of ulcerative colitis in mice. Journal of integrative medicine, , Volume: 11, Issue:3	2013
Evaluation of new scaffolds of myeloperoxidase inhibitors by rational design combined with high-throughput virtual screening. Journal of medicinal chemistry, , Aug-23, Volume: 55, Issue:16	2012
Time-dependent oxidative stress responses of submerged macrophyte Vallisneria natans seedlings exposed to ammonia in combination with microcystin under laboratory conditions. Bulletin of environmental contamination and toxicology, , Volume: 89, Issue:1	2012
Comparative evaluation of different doses of green tea extract alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats. Digestive diseases and sciences, , Volume: 56, Issue:5	2011
[Effect of cadmium, alone or in combination with CaCl2, on the growth, antioxidative enzyme activity and cadmium absorption of Solanum nigrum L. var pauciflorum hairy roots]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology, , Volume: 26, Issue:2	2010
Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice. Journal of medical microbiology, , Volume: 59, Issue:Pt 4	2010
Protective effects of emodin combined with danshensu on experimental severe acute pancreatitis. Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 59, Issue:6	2010
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Graphene-Based Nanomaterials as Efficient Peroxidase Mimetic Catalysts for Biosensing Applications: An Overview. Molecules (Basel, Switzerland), , Aug-04, Volume: 20, Issue:8	2015
Picroliv preconditioning protects the rat liver against ischemia-reperfusion injury. European journal of pharmacology, , May-03, Volume: 395, Issue:3	2000

mocetinostat

Description

Cross-References

Synonyms (74)

Roles (6)

Drug Classes (6)

Protein Targets (27)

Potency Measurements

Inhibition Measurements

Bioassays (250)

Research

Studies (20,895)

Study Types

Related Drugs (5,631)

Drugs in this Class (1,216)

Drugs with this Function (1,020)

Drugs in Same Class and Function (143)

Drugs Involved in Assays Together (876)

Drugs Researched Together (3,365)

Related Conditions (2,535)

Safety/Toxicity (268)

Long-term Use (28)

Pharmacokinetics (53)

Bioavailability (97)

Dosage (242)

Interactions (29)

Natural Sources (2)