A sterol O-acyltransferase 1 that is encoded in the genome of rat. [OMA:O70536, PRO:DNx]
EC 2.3.1.26;
Acyl-coenzyme A:cholesterol acyltransferase 1;
ACAT-1;
Cholesterol acyltransferase 1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (71.43) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| aminoglutethimide | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| procainamide | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| edrophonium chloride | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 1 |
| lophine | Rattus norvegicus (Norway rat) | IC50 | 0.2600 | 1 | 1 |
| lecimibide | Rattus norvegicus (Norway rat) | IC50 | 0.2800 | 3 | 3 |
| pd 128042 | Rattus norvegicus (Norway rat) | IC50 | 2.1277 | 3 | 3 |
| n-(4-(2-chlorophenyl)-6,7-dimethyl-3-quinolyl)-n'-(2,4-difluorophenyl)urea | Rattus norvegicus (Norway rat) | IC50 | 0.0058 | 1 | 1 |
| 1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone | Rattus norvegicus (Norway rat) | IC50 | 18.3333 | 2 | 3 |
| avasimibe | Rattus norvegicus (Norway rat) | IC50 | 0.5345 | 2 | 2 |
| oleic acid | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| linoleic acid | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| oleylamide | Rattus norvegicus (Norway rat) | IC50 | 170.0000 | 1 | 1 |
| oleoylanilide | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
| linoleamide | Rattus norvegicus (Norway rat) | IC50 | 150.0000 | 1 | 1 |
| l 006235 | Rattus norvegicus (Norway rat) | IC50 | 0.3290 | 2 | 2 |
| balicatib | Rattus norvegicus (Norway rat) | IC50 | 0.2640 | 2 | 2 |
| ilekudinol b | Rattus norvegicus (Norway rat) | IC50 | 44.0000 | 1 | 1 |
| protopanaxadiol, (3beta,12beta)-isomer | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 2 |
| 23-hydroxyursolic acid | Rattus norvegicus (Norway rat) | IC50 | 64.0000 | 1 | 1 |