doxapram has been researched along with Necrosis in 1 studies
Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the first case of acute hepatic necrosis, which we believe to have been caused by the administration of the respiratory stimulant, doxapram hydrochloride (Dopram)." | 7.67 | Hepatic necrosis with doxapram hydrochloride. ( Ashton, RJ; Fancourt, GJ; Talbot, IC; Wales, JM, 1985) |
| "We report the first case of acute hepatic necrosis, which we believe to have been caused by the administration of the respiratory stimulant, doxapram hydrochloride (Dopram)." | 3.67 | Hepatic necrosis with doxapram hydrochloride. ( Ashton, RJ; Fancourt, GJ; Talbot, IC; Wales, JM, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fancourt, GJ | 1 |
| Ashton, RJ | 1 |
| Talbot, IC | 1 |
| Wales, JM | 1 |
1 other study available for doxapram and Necrosis
| Article | Year |
|---|---|
Hepatic necrosis with doxapram hydrochloride.
Topics: Aged; Chemical and Drug Induced Liver Injury; Doxapram; Humans; Liver Diseases; Male; Necrosis | 1985 |