Proteins > Ephrin type-A receptor 6
Page last updated: 2024-08-08 00:21:12

Ephrin type-A receptor 6

An ephrin type-A receptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UF33]

Synonyms

EC 2.7.10.1;
EPH homology kinase 2;
EHK-2;
EPH-like kinase 12;
EK12

Research

Bioassay Publications (7)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80

Compounds (76)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
staurosporineHomo sapiens (human)IC500.016022
nvp-bhg712Homo sapiens (human)IC500.263010

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sb 202190Homo sapiens (human)Kd2.200011
imatinibHomo sapiens (human)Kd10.000022
staurosporineHomo sapiens (human)Kd0.273333
gefitinibHomo sapiens (human)Kd0.860033
lestaurtinibHomo sapiens (human)Kd1.200022
vatalanibHomo sapiens (human)Kd10.000022
ruboxistaurinHomo sapiens (human)Kd10.000022
canertinibHomo sapiens (human)Kd0.204033
birb 796Homo sapiens (human)Kd1.476733
cyc 202Homo sapiens (human)Kd10.000011
sb 203580Homo sapiens (human)Kd1.200022
enzastaurinHomo sapiens (human)Kd10.000011
erlotinibHomo sapiens (human)Kd0.685044
lapatinibHomo sapiens (human)Kd10.000022
sorafenibHomo sapiens (human)Kd0.318055
pd 173955Homo sapiens (human)Kd0.070011
s 1033Homo sapiens (human)Kd0.640011
bms 387032Homo sapiens (human)Kd10.000022
tandutinibHomo sapiens (human)Kd10.000033
vx-745Homo sapiens (human)Kd10.000022
dasatinibHomo sapiens (human)Kd6.050022
zd 6474Homo sapiens (human)Kd0.055033
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamideHomo sapiens (human)Kd10.000011
alvocidibHomo sapiens (human)Kd10.000022
bosutinibHomo sapiens (human)Kd1.100011
su 11248Homo sapiens (human)Kd1.220044
jnj-7706621Homo sapiens (human)Kd10.000011
vx680Homo sapiens (human)Kd7.350022
ekb 569Homo sapiens (human)Kd7.050022
axitinibHomo sapiens (human)Kd10.000011
pd 184352Homo sapiens (human)Kd10.000011
bms345541Homo sapiens (human)Kd10.000011
midostaurinHomo sapiens (human)Kd10.000033
ki 20227Homo sapiens (human)Kd10.000011
cp 724714Homo sapiens (human)Kd10.000011
pi103Homo sapiens (human)Kd10.000022
hki 272Homo sapiens (human)Kd10.000011
tofacitinibHomo sapiens (human)Kd10.000022
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamideHomo sapiens (human)Kd10.000011
cediranibHomo sapiens (human)Kd0.036011
masitinibHomo sapiens (human)Kd10.000011
pazopanibHomo sapiens (human)Kd10.000022
azd 6244Homo sapiens (human)Kd10.000011
su 14813Homo sapiens (human)Kd2.000022
bibw 2992Homo sapiens (human)Kd0.340011
tg100-115Homo sapiens (human)Kd10.000011
pha 665752Homo sapiens (human)Kd10.000011
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd0.120011
brivanibHomo sapiens (human)Kd0.190011
at 7519Homo sapiens (human)Kd10.000011
bi 2536Homo sapiens (human)Kd10.000011
nvp-ast487Homo sapiens (human)Kd0.380022
kw 2449Homo sapiens (human)Kd1.500011
abt 869Homo sapiens (human)Kd0.330022
gw 2580Homo sapiens (human)Kd10.000022
crizotinibHomo sapiens (human)Kd0.065011
chir-265Homo sapiens (human)Kd1.500022
motesanibHomo sapiens (human)Kd0.490022
mln8054Homo sapiens (human)Kd0.580022
GDC-0879Homo sapiens (human)Kd10.000011
gsk 461364Homo sapiens (human)Kd10.000011
azd 1152-hqpaHomo sapiens (human)Kd10.000022
nvp-tae684Homo sapiens (human)Kd0.120011
fedratinibHomo sapiens (human)Kd3.900011
gsk690693Homo sapiens (human)Kd10.000011
gdc 0941Homo sapiens (human)Kd10.000011
plx 4720Homo sapiens (human)Kd10.000011
sgx 523Homo sapiens (human)Kd10.000011
quizartinibHomo sapiens (human)Kd9.550022
incb-018424Homo sapiens (human)Kd10.000011
gsk 1838705aHomo sapiens (human)Kd10.000011
gsk 1363089Homo sapiens (human)Kd0.001111
chir 258Homo sapiens (human)Kd10.000022
nintedanibHomo sapiens (human)Kd0.940011
pp242Homo sapiens (human)Kd0.210011

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
molecular_functionmolecular functionA molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. [GOC:pdt]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
transmembrane-ephrin receptor activitymolecular functionCombining with a transmembrane ephrin to initiate a change in cell activity. [GOC:mah, PMID:9530499]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
dendritecellular componentA neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 4 target(s):

TargetCategoryDefinition
biological_processbiological processA biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. [GOC:pdt]
axon guidancebiological processThe chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437]
ephrin receptor signaling pathwaybiological processThe series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]
protein phosphorylationbiological processThe process of introducing a phosphate group on to a protein. [GOC:hb]