Ephrin type-A receptor 6

An ephrin type-A receptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UF33]

Synonyms

EC 2.7.10.1;
EPH homology kinase 2;
EHK-2;
EPH-like kinase 12;
EK12

Research

Bioassay Publications (7)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (57.14)	29.6817
2010's	3 (42.86)	24.3611
2020's	0 (0.00)	2.80

Compounds (76)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
staurosporine	Homo sapiens (human)	IC50	0.0160	2	2
nvp-bhg712	Homo sapiens (human)	IC50	0.2630	1	0

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sb 202190	Homo sapiens (human)	Kd	2.2000	1	1
imatinib	Homo sapiens (human)	Kd	10.0000	2	2
staurosporine	Homo sapiens (human)	Kd	0.2733	3	3
gefitinib	Homo sapiens (human)	Kd	0.8600	3	3
lestaurtinib	Homo sapiens (human)	Kd	1.2000	2	2
vatalanib	Homo sapiens (human)	Kd	10.0000	2	2
ruboxistaurin	Homo sapiens (human)	Kd	10.0000	2	2
canertinib	Homo sapiens (human)	Kd	0.2040	3	3
birb 796	Homo sapiens (human)	Kd	1.4767	3	3
cyc 202	Homo sapiens (human)	Kd	10.0000	1	1
sb 203580	Homo sapiens (human)	Kd	1.2000	2	2
enzastaurin	Homo sapiens (human)	Kd	10.0000	1	1
erlotinib	Homo sapiens (human)	Kd	0.6850	4	4
lapatinib	Homo sapiens (human)	Kd	10.0000	2	2
sorafenib	Homo sapiens (human)	Kd	0.3180	5	5
pd 173955	Homo sapiens (human)	Kd	0.0700	1	1
s 1033	Homo sapiens (human)	Kd	0.6400	1	1
bms 387032	Homo sapiens (human)	Kd	10.0000	2	2
tandutinib	Homo sapiens (human)	Kd	10.0000	3	3
vx-745	Homo sapiens (human)	Kd	10.0000	2	2
dasatinib	Homo sapiens (human)	Kd	6.0500	2	2
zd 6474	Homo sapiens (human)	Kd	0.0550	3	3
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide	Homo sapiens (human)	Kd	10.0000	1	1
alvocidib	Homo sapiens (human)	Kd	10.0000	2	2
bosutinib	Homo sapiens (human)	Kd	1.1000	1	1
su 11248	Homo sapiens (human)	Kd	1.2200	4	4
jnj-7706621	Homo sapiens (human)	Kd	10.0000	1	1
vx680	Homo sapiens (human)	Kd	7.3500	2	2
ekb 569	Homo sapiens (human)	Kd	7.0500	2	2
axitinib	Homo sapiens (human)	Kd	10.0000	1	1
pd 184352	Homo sapiens (human)	Kd	10.0000	1	1
bms345541	Homo sapiens (human)	Kd	10.0000	1	1
midostaurin	Homo sapiens (human)	Kd	10.0000	3	3
ki 20227	Homo sapiens (human)	Kd	10.0000	1	1
cp 724714	Homo sapiens (human)	Kd	10.0000	1	1
pi103	Homo sapiens (human)	Kd	10.0000	2	2
hki 272	Homo sapiens (human)	Kd	10.0000	1	1
tofacitinib	Homo sapiens (human)	Kd	10.0000	2	2
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide	Homo sapiens (human)	Kd	10.0000	1	1
cediranib	Homo sapiens (human)	Kd	0.0360	1	1
masitinib	Homo sapiens (human)	Kd	10.0000	1	1
pazopanib	Homo sapiens (human)	Kd	10.0000	2	2
azd 6244	Homo sapiens (human)	Kd	10.0000	1	1
su 14813	Homo sapiens (human)	Kd	2.0000	2	2
bibw 2992	Homo sapiens (human)	Kd	0.3400	1	1
tg100-115	Homo sapiens (human)	Kd	10.0000	1	1
pha 665752	Homo sapiens (human)	Kd	10.0000	1	1
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one	Homo sapiens (human)	Kd	0.1200	1	1
brivanib	Homo sapiens (human)	Kd	0.1900	1	1
at 7519	Homo sapiens (human)	Kd	10.0000	1	1
bi 2536	Homo sapiens (human)	Kd	10.0000	1	1
nvp-ast487	Homo sapiens (human)	Kd	0.3800	2	2
kw 2449	Homo sapiens (human)	Kd	1.5000	1	1
abt 869	Homo sapiens (human)	Kd	0.3300	2	2
gw 2580	Homo sapiens (human)	Kd	10.0000	2	2
crizotinib	Homo sapiens (human)	Kd	0.0650	1	1
chir-265	Homo sapiens (human)	Kd	1.5000	2	2
motesanib	Homo sapiens (human)	Kd	0.4900	2	2
mln8054	Homo sapiens (human)	Kd	0.5800	2	2
GDC-0879	Homo sapiens (human)	Kd	10.0000	1	1
gsk 461364	Homo sapiens (human)	Kd	10.0000	1	1
azd 1152-hqpa	Homo sapiens (human)	Kd	10.0000	2	2
nvp-tae684	Homo sapiens (human)	Kd	0.1200	1	1
fedratinib	Homo sapiens (human)	Kd	3.9000	1	1
gsk690693	Homo sapiens (human)	Kd	10.0000	1	1
gdc 0941	Homo sapiens (human)	Kd	10.0000	1	1
plx 4720	Homo sapiens (human)	Kd	10.0000	1	1
sgx 523	Homo sapiens (human)	Kd	10.0000	1	1
quizartinib	Homo sapiens (human)	Kd	9.5500	2	2
incb-018424	Homo sapiens (human)	Kd	10.0000	1	1
gsk 1838705a	Homo sapiens (human)	Kd	10.0000	1	1
gsk 1363089	Homo sapiens (human)	Kd	0.0011	1	1
chir 258	Homo sapiens (human)	Kd	10.0000	2	2
nintedanib	Homo sapiens (human)	Kd	0.9400	1	1
pp242	Homo sapiens (human)	Kd	0.2100	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
molecular_function	molecular function	A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. [GOC:pdt]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
transmembrane-ephrin receptor activity	molecular function	Combining with a transmembrane ephrin to initiate a change in cell activity. [GOC:mah, PMID:9530499]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
dendrite	cellular component	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 4 target(s):

Target	Category	Definition
biological_process	biological process	A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. [GOC:pdt]
axon guidance	biological process	The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437]
ephrin receptor signaling pathway	biological process	The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]
protein phosphorylation	biological process	The process of introducing a phosphate group on to a protein. [GOC:hb]

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