A cytochrome P450 2D6 that is encoded in the genome of rat. [PRO:DNx]
EC 1.14.14.1;
CYPIID18;
CYPIID4;
Cytochrome P450 2D-29;
Cytochrome P450 2D-35;
Cytochrome P450 2D18;
Cytochrome P450-CMF3;
Cytochrome P450-DB4;
Debrisoquine 4-hydroxylase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| debrisoquin | Rattus norvegicus (Norway rat) | IC50 | 747.0000 | 1 | 1 |
| nortriptyline | Rattus norvegicus (Norway rat) | IC50 | 19.3000 | 1 | 1 |
| phenformin | Rattus norvegicus (Norway rat) | IC50 | 833.0000 | 1 | 1 |
| dexpropranolol | Rattus norvegicus (Norway rat) | IC50 | 117.0000 | 1 | 1 |
| quinidine | Rattus norvegicus (Norway rat) | IC50 | 47.2000 | 1 | 1 |
| quinine | Rattus norvegicus (Norway rat) | IC50 | 1.7000 | 1 | 1 |
| codeine | Rattus norvegicus (Norway rat) | IC50 | 2,216.0000 | 1 | 1 |
| dextromethorphan | Rattus norvegicus (Norway rat) | IC50 | 136.0000 | 1 | 1 |
| 4-(6-iodo-2-imidazo[1,2-a]pyridinyl)-N,N-dimethylaniline | Rattus norvegicus (Norway rat) | Ki | 0.0080 | 1 | 1 |