Proteins > Matrix metalloproteinase-14
Page last updated: 2024-08-07 16:47:20

Matrix metalloproteinase-14

A matrix metalloproteinase-14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50281]

Synonyms

MMP-14;
EC 3.4.24.80;
MMP-X1;
Membrane-type matrix metalloproteinase 1;
MT-MMP 1;
MTMMP1;
Membrane-type-1 matrix metalloproteinase;
MT1-MMP;
MT1MMP

Research

Bioassay Publications (39)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (2.56)18.2507
2000's19 (48.72)29.6817
2010's16 (41.03)24.3611
2020's3 (7.69)2.80

Compounds (26)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
tiludronic acidHomo sapiens (human)IC5030.500011
epigallocatechin gallateHomo sapiens (human)IC506.800011
zoledronic acidHomo sapiens (human)IC5012.600011
marimastatHomo sapiens (human)IC503.334533
ilomastatHomo sapiens (human)IC500.01021010
cgs 27023aHomo sapiens (human)IC500.023011
prinomastatHomo sapiens (human)IC500.000311
rs-130830Homo sapiens (human)IC500.004344
tmi-1Homo sapiens (human)IC500.011128
batimastatHomo sapiens (human)IC500.571555
ik 682Homo sapiens (human)Ki15.872022
epigallocatechin-3-o-(3''-o-methyl)-gallateHomo sapiens (human)IC501.700011
ro 32-3555Homo sapiens (human)IC500.023011
sb 3ct compoundHomo sapiens (human)Ki0.085733
pd 166793Homo sapiens (human)IC500.240011
sc 78080Homo sapiens (human)IC500.013011
sc 78080Homo sapiens (human)Ki0.014011
ro 31-9790Homo sapiens (human)IC500.001911
arp-100Homo sapiens (human)IC503.858234
kb r8301Homo sapiens (human)IC500.002111
N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamideHomo sapiens (human)IC500.009822
bms-566394Homo sapiens (human)Ki10.000022
incb3619Homo sapiens (human)IC500.772022
6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrileHomo sapiens (human)IC5072.443611
6-(3,5-difluoroanilino)-9-(2,2-difluoroethyl)-2-purinecarbonitrileHomo sapiens (human)IC50426.580011
9-(3,5-difluorophenyl)-6-(ethylamino)-2-purinecarbonitrileHomo sapiens (human)IC50134.896011
grassystatin aHomo sapiens (human)IC505.000011

Enables

This protein enables 7 target(s):

TargetCategoryDefinition
endopeptidase activitymolecular functionCatalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
metalloendopeptidase activitymolecular functionCatalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
serine-type endopeptidase activitymolecular functionCatalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
integrin bindingmolecular functionBinding to an integrin. [GOC:ceb]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
metalloaminopeptidase activitymolecular functionCatalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]

Located In

This protein is located in 11 target(s):

TargetCategoryDefinition
extracellular spacecellular componentThat part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
Golgi lumencellular componentThe volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. [GOC:mah]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
focal adhesioncellular componentA cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]
extracellular matrixcellular componentA structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]
cytoplasmic vesiclecellular componentA vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles]
melanosomecellular componentA tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. [GOC:jl, PMID:11584301]
macropinosomecellular componentA membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis. [PMID:14732047]
intermediate filament cytoskeletoncellular componentCytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. [ISBN:0716731363]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
extracellular spacecellular componentThat part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Involved In

This protein is involved in 39 target(s):

TargetCategoryDefinition
angiogenesisbiological processBlood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
ovarian follicle developmentbiological processThe process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
response to hypoxiabiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd]
endothelial cell proliferationbiological processThe multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. [GOC:add, ISBN:0781735149]
endochondral ossificationbiological processReplacement ossification wherein bone tissue replaces cartilage. [GO_REF:0000034, ISBN:0878932437]
proteolysisbiological processThe hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
response to oxidative stressbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:jl, PMID:12115731]
male gonad developmentbiological processThe process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. [GOC:jid]
response to mechanical stimulusbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. [GOC:hb]
positive regulation of myotube differentiationbiological processAny process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:dph, GOC:tb]
positive regulation of protein processingbiological processAny process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage. [GOC:dph, GOC:mah, GOC:tb]
response to organic cyclic compoundbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. [GOC:ef]
protein processingbiological processAny protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. [GOC:curators, GOC:jl, GOC:jsg]
extracellular matrix disassemblybiological processA process that results in the breakdown of the extracellular matrix. [GOC:jid]
protein catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:mah]
positive regulation of cell growthbiological processAny process that activates or increases the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
lung developmentbiological processThe process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. [GOC:jid, UBERON:0002048]
positive regulation of cell migrationbiological processAny process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
collagen catabolic processbiological processThe proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. [GOC:mah, ISBN:0815316194]
zymogen activationbiological processThe proteolytic processing of an inactive enzyme to an active form. [GOC:hjd]
endodermal cell differentiationbiological processThe process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. [CL:0000223, GOC:yaf, PMID:17624332]
chondrocyte proliferationbiological processThe multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage. [CL:0000138, GOC:yaf, PMID:21484705]
astrocyte cell migrationbiological processThe orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord. [CL:0000127, GOC:go_curators]
response to estrogenbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. [GOC:jl, ISBN:0198506732]
positive regulation of B cell differentiationbiological processAny process that activates or increases the frequency, rate or extent of B cell differentiation. [GOC:go_curators]
negative regulation of Notch signaling pathwaybiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway. [GOC:go_curators]
embryonic cranial skeleton morphogenesisbiological processThe process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase. [GOC:dsf, GOC:jid, PMID:16049113]
branching morphogenesis of an epithelial tubebiological processThe process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. [GOC:dgh, GOC:dph, GOC:jid]
tissue remodelingbiological processThe reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. [GOC:ebc]
cell motilitybiological processAny process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]
negative regulation of focal adhesion assemblybiological processAny process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. [GOC:ai]
head developmentbiological processThe biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. [GOC:dph]
craniofacial suture morphogenesisbiological processThe process in which any suture between cranial and/or facial bones is generated and organized. [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]
negative regulation of GDF15-GFRAL signaling pathwaybiological processAny process that stops, prevents or reduces the frequency, rate or extent of GDF15-GFRAL signaling pathway. [PMID:35177851]
regulation of protein localization to plasma membranebiological processAny process that modulates the frequency, rate or extent of protein localization to plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
positive regulation of macrophage migrationbiological processAny process that activates or increases the frequency, rate or extent of macrophage migration. [GO_REF:0000058, GOC:TermGenie, PMID:25749876]
response to odorantbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell. [PMID:11268007]
extracellular matrix organizationbiological processA process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. [GOC:mah]
skeletal system developmentbiological processThe process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). [GOC:dph, GOC:jid, GOC:tb]