galactosamine has been researched along with Necrosis in 116 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (38.79) | 18.7374 |
| 1990's | 25 (21.55) | 18.2507 |
| 2000's | 25 (21.55) | 29.6817 |
| 2010's | 17 (14.66) | 24.3611 |
| 2020's | 4 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Bogunia, E; Czekaj, P; Grajoszek, A; Hermyt, M; Kolanko, E; Król, M; Limanówka, Ł; Michalik, M; Pająk, J; Prusek, A; Sikora, B; Skubis-Sikora, A | 1 |
| Cai, L; Feng, L; Fu, Y; Gao, Y; Jiang, Z; Liu, S; Wang, Y; Xu, X; Zhang, L; Zhou, C | 1 |
| Cho, KM; Dusabimana, T; Je, J; Jeong, K; Kim, H; Kim, HJ; Kim, SR; Park, EJ; Park, SW; Yun, SP | 1 |
| Feng, J; Lu, J; Qian, M; Shangguan, W; Wang, Y; Wu, Y; Zhang, Q; Zhao, W | 1 |
| Hong, JM; Kim, SJ; Lee, SM; Seo, MJ | 1 |
| Gu, Y; Li, XR; Wang, HT; Wang, JB; Wang, W; Wang, Y; Yang, S; Zhang, MX; Zhao, YT | 1 |
| Izawa, T; Karim, MR; Kuramochi, M; Kuwamura, M; Pervin, M; Rahman, N; Yamate, J | 1 |
| Hata, T; Hori, T; Nguyen, JH; Rehman, F | 1 |
| Antoine, DJ; Bajt, ML; Jaeschke, H; Jenkins, RE; Park, BK; Woolbright, BL | 1 |
| Gao, M; Guo, C; Li, Y; Liu, X; Liu, Y; Ma, Y; Mao, H; Wang, X; Wei, Z; Zhang, L | 1 |
| Cao, HC; Li, J; Li, LJ; Pan, QL; Yang, JF; Yu, J | 1 |
| Gao, WS; Li, LP; Liu, JY; Wang, HT; Wang, JB; Wang, W; Yan, YC; Zhang, MX; Zhao, YT | 1 |
| Červinková, Z; Kučera, O; Lotková, H; Sobotka, O | 1 |
| Chao, X; Ding, WX; Jaeschke, H; McGill, MR; Ni, HM; Woolbright, BL | 1 |
| Han, YP; Yan, C; Zhou, L | 1 |
| Godes, M; Heiden, S; Hocher, B; Kalk, P; Pfab, T; Relle, K; Theuring, F; Vignon-Zellweger, N; von Websky, K; Zidek, W | 1 |
| Chen, X; Ding, WX; Ni, HM; Schuchmann, M; Yin, XM | 1 |
| DeFrances, MC; Gandhi, CR; Han, C; Li, G; Lim, K; Wu, T | 1 |
| Farhood, A; Hong, JY; Jaeschke, H; Lebofsky, M | 1 |
| Abshagen, K; Eipel, C; Kuhla, A; Menger, MD; Siebert, N; Vollmar, B | 1 |
| Csizmadia, E; Da Silva, CG; Damrauer, SM; Daniel, S; Ferran, C; Longo, CR; Patel, VI; Ramsey, HE; Siracuse, JJ; Studer, P | 1 |
| Andersen, ME; Brees, DJ; Loy, J; Singh, R; Thomas, RS; Watkins, PB; Wetmore, BA | 1 |
| Brown, M; Dasari, M; Davis, M; Kim, D; Lee, S; Murthy, N; Sy, J | 1 |
| Fu, JL; Li, GZ; Liu, P; Wang, YR; Wang, ZH | 1 |
| Ataya, FS; Fouad, D; Muntane, J | 1 |
| Bruno, S; Camussi, G; Fonsato, V; Gilbo, N; Grange, C; Herrera, MB; Romagnoli, R; Tetta, C | 1 |
| Balasekar, P; Banu, S; Bhaskar, B | 1 |
| Deng, Y; Sun, L; Tang, J; Wang, W | 1 |
| Bajt, ML; Ho, YS; Jaeschke, H; Vonderfecht, SL | 1 |
| Hamagawa, E; Kakuta, Y; Kojo, S; Sakaguchi, N; Sun, F; Tokumaru, S; Tsutsui, C | 1 |
| Farhood, A; Gujral, JS; Jaeschke, H | 1 |
| Collado, JA; Lozano, JM; Medina, T; Muntané, J | 1 |
| Costán, G; Fouad, D; Muntané, J; Siendones, E | 1 |
| Asamoto, M; Hokaiwado, N; Murasaki, T; Shirai, T | 1 |
| Chiba, S; Endo, M; Kakuma, T; Masaki, T; Noguchi, H; Seike, M; Tatsukawa, H; Watanabe, T; Yoshimatsu, H | 1 |
| Mas, R; Mendoza, N; Mendoza, S; Noa, M | 1 |
| Bernardos, A; Corrales, FJ; González, R; López, P; López-Sánchez, LM; Muntané, J; Rodríguez-Ariza, A | 1 |
| Hirao, Y; Kamiyama, Y; Kwon, AH; Okumura, T; Qiu, Z; Tsuji, K | 1 |
| Asaoka, A; Hikosaka, K; Hirota, Y; Kitani, H; Koyama, Y; Motobu, M; Nakai, Y; Nakamura, K; Saido-Sakanaka, H; Sekikawa, K; Shimura, K; Yamada, M; Yamakawa, M | 1 |
| Fujii, K; Ichi, I; Iida, C; Koga, E; Kojo, S; Washino, Y | 1 |
| Adeyemo, O; Hanig, JP; Knapton, A; Miller, TJ; Noory, L; Weaver, J | 1 |
| Lapis, K; Schaff, Z; Szendröi, M | 1 |
| Kan, M; Ozeki, T; Taoka, Y; Yamagata, S | 1 |
| Buckley, AR; Karrer, FM; Putnam, CW; Rhenman, B; Steinbronn, K; Warneke, JA | 1 |
| Castro, JA; de Fenos, OM; de Ferreyra, EC | 3 |
| Klouchek-Popova, E; Popov, A; Stoilova, M | 1 |
| Rikans, LE | 1 |
| Gandolfi, AJ; MacDonald, JR; Sipes, IG | 2 |
| Asanuma, Y; Koyama, K; Okabe, K; Ouchi, K; Sato, T | 1 |
| Kagamiyama, H; Sakakibara, S; Shibayama, Y; Ueda, I | 1 |
| Blendis, LM; Falk, JA; Falk, RE; Langer, B; Makowka, L; Nossal, N; Phillips, MJ; Rotstein, LE | 1 |
| Farber, JL | 1 |
| Farber, JL; Rubin, E; Schanne, FA; Zucker, AH | 1 |
| Shinohara, T; Tsuji, T | 1 |
| Barsig, J; Bohlinger, I; Leist, M; Tiegs, G; Uhlig, S; Wendel, A | 1 |
| Lassila, V; Söderström, KO; Virtanen, P | 1 |
| Bahrami, S; Leichtfried, G; Redl, H; Schlag, G; Yu, Y | 1 |
| Decker, K | 1 |
| Chang, CH; Hattori, M; Lin, CC; Namba, T; Yang, JJ | 1 |
| Si, C; Tian, X; Yu, Y | 1 |
| Gantner, F; Uhlig, S; Wendel, A | 1 |
| Basnet, P; Hase, K; Kadota, S; Namba, T; Takahashi, T | 1 |
| Angermüller, S; Bohlinger, I; Gantner, F; Leist, M; Tiegs, G; Wendel, A | 1 |
| Timbrell, JA; Waterfield, CJ | 1 |
| Blumenthal, S; Diaz-Buxo, JA; Gordon, B; Gores, P; Hayes, D | 1 |
| Lang, Z; Si, C; Yu, Y | 1 |
| Doi, K; Hirasawa, K; Itagaki, S; Kawamura, S; Maeda, K; Mikami, T; Takeda, M; Tsutsui, S | 1 |
| Farhood, A; Fisher, MA; Jaeschke, H; Jones, DA; Lawson, JA; Simmons, CA | 1 |
| Okita, K; Sakaida, I; Takenaka, K; Yasunaga, M | 1 |
| Chance, B; Hatano, E; Ikai, I; Iwata, S; Kanazawa, A; Kitai, T; Satoh, S; Shinohara, H; Takahashi, R; Tanaka, A; Tsunekawa, S; Yamamoto, M; Yamaoka, Y | 1 |
| Gopumadhavan, S; Mitra, SK; Sarma, DN; Seshadri, SJ; Udupa, UV; Venkataranganna, MV | 1 |
| Brouckaert, P; Hochepied, T; Libert, C; Van Molle, W | 1 |
| Bahjat, FR; Edwards, CK; Moldawer, LL; Oberholzer, A; Oberholzer, C | 1 |
| Colell, A; De la Mata, M; Fernández-Checa, JC; García-Ruiz, C; Kamal ElSaid, AM; Miño, G; Montero, JL; Muntané, J; Pedraza, CA; Quintero, A; Siendones, E | 1 |
| Horikawa, T; Nakazato, H; Oku, H; Suzuki, R; Tsuruta, Y | 1 |
| Carswell, EA; Dobrjansky, A; Fiore, N; Green, S; Kassel, RL; Old, LJ; Schwartz, MK | 1 |
| Gochman, N; Sell, S; Stillman, D | 1 |
| Grün, M; Heine, WD; Liehr, H; Reutter, W; Seelig, HP; Seelig, R | 1 |
| Chang, TM; Chirito, E; Lister, C | 1 |
| Barnes, S; Foster, MM; Hirschowitz, BI; Mihas, AA; Mihas, TA; Spenney, JG | 1 |
| Grün, M; Liehr, H; Rasenack, U; Seelig, HP; Seelig, R | 1 |
| Ragland, JB; Sabesin, SM | 1 |
| Bartsokas, SK; Papadimitriou, DG | 1 |
| Grün, M; Liehr, H; Rasenack, U | 1 |
| El-Mofty, SK; Farber, JL | 1 |
| Bode, C; Rumpelt, HJ | 1 |
| Kisfaludy, S | 1 |
| Connelly, LJ; Koff, RS | 1 |
| Abdul-Hussain, SK; Mehendale, HM | 1 |
| Boes, A; Dijkhuis, FW; Grond, J; Hardonk, MJ; Jonker, AM | 1 |
| Chen, Y; Yang, WS; Yao, ZQ; Zhang, WB; Zhou, YX | 1 |
| Laconi, E; Pani, P; Sarma, DS | 1 |
| Harada, M; Hino, Y; Kumashiro, R; Sata, M; Shimada, M; Tanaka, M; Tanikawa, K; Yoshitake, M | 1 |
| Borle, AB; Fagiuoli, S; Farghali, H; Francavilla, A; Gasbarrini, A; Nalesnik, MA; Starzl, TE; Van Thiel, DH | 1 |
| Fujimura, S; Kato, N; Miyazaki, M; Moriyama, Y; Nakagawa, K; Okui, K | 1 |
| Chen, YN; Yang, FY; Yang, WS; Yao, ZQ; Zhang, WB | 1 |
| Dijkhuis, FW; Grond, J; Hardonk, MJ; Jonker, AM; Kroese, FG | 1 |
| Kakisaka, A; Kasai, S; Mito, M | 1 |
| Ando, T; Moriwaki, H; Muto, Y; Okuno, F; Seishima, M; Yamada, M; Yoshida, H | 1 |
| Fukuda, Y; Imoto, M; Koyama, Y; Ozawa, T; Satake, T; Tanaka, M | 1 |
| Adzharov, D; Borov, B; Donchev, N; Kerimova, M; Naĭdenova, E | 1 |
| Gordon, P; Kellen, J; Klein, A; Kolin, A; Malkin, A; Pappas, SC; Robinson, JB; Wong, A | 1 |
| Hu, DR; Li, MD; Xie, J | 1 |
| Hughes, RD; Noda, Y; Williams, R | 1 |
| Brachtel, D; Richter, E | 1 |
| Kobayashi, A; Sugata, F; Tsubomizu, Y | 1 |
| Malchesky, PS; Nose, Y; Okabe, K; Sakamoto, H; Smith, JW; Takaoka, T; Tuthill, RJ; Usami, M | 1 |
| Dumont, JM; Maignan, MF; Perrissoud, D | 1 |
| Hinek, A; Samochowiec, L; Wójcicki, J | 1 |
| Davidson, LJ; Gordon, G; Koff, RS; Sabesin, SM | 1 |
| Anukarahanonta, T; Farber, JL; Konishi, Y; Shinozuka, H | 1 |
| Hey, D; Krause, W; Leinweber, B | 1 |
| Koff, RS | 1 |
1 review(s) available for galactosamine and Necrosis
| Article | Year |
|---|---|
Calcium and the mechanisms of liver necrosis.
Topics: Animals; Calcium; Carbon Tetrachloride; Cell Membrane; Chemical and Drug Induced Liver Injury; Galactosamine; In Vitro Techniques; Liver; Liver Diseases; Necrosis; Phalloidine; Rats | 1982 |
115 other study(ies) available for galactosamine and Necrosis
| Article | Year |
|---|---|
Dynamics of Acute Liver Injury in Experimental Models of Hepatotoxicity in the Context of Their Implementation in Preclinical Studies on Stem Cell Therapy.
Topics: Animals; Cell- and Tissue-Based Therapy; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Lipopolysaccharides; Liver; Liver Failure, Acute; Mice; Necrosis; Rats | 2022 |
Establishment of acute liver failure model in Tibetan miniature pig and verified by dual plasma molecular adsorption system.
Topics: Adsorption; Ammonia; Animals; Disease Models, Animal; Galactosamine; Lipopolysaccharides; Liver; Liver Failure, Acute; Necrosis; Swine; Swine, Miniature; Tibet | 2023 |
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Endotoxins; Fermentation; Galactosamine; Inflammation; Lipid Peroxidation; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Nitric Oxide; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Platycodon; RAW 264.7 Cells; Signal Transduction | 2020 |
Design and biological evaluation of novel long-acting adalimumab Fab conjugated with the albumin binding domain.
Topics: Adalimumab; Albumins; Animals; Anti-Inflammatory Agents; Cell Death; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Drug Design; Female; Galactosamine; Half-Life; Humans; Hydrogen-Ion Concentration; Immunoglobulin Fab Fragments; Injections, Intraperitoneal; Mice, Inbred BALB C; Necrosis; Protein Binding; Protein Domains; Receptors, Fc; Recombinant Fusion Proteins; Serum Albumin, Human; Tumor Necrosis Factor-alpha | 2021 |
Genipin protects d-galactosamine and lipopolysaccharide-induced hepatic injury through suppression of the necroptosis-mediated inflammasome signaling.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Galactosamine; Inflammasomes; Iridoids; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Necrosis; NLR Family, Pyrin Domain-Containing 3 Protein; Receptors, Pattern Recognition; Signal Transduction | 2017 |
High expression of type I inositol 1,4,5-trisphosphate receptor in the kidney of rats with hepatorenal syndrome.
Topics: Animals; Disease Models, Animal; Galactosamine; Hepatocytes; Hepatorenal Syndrome; Humans; Inositol 1,4,5-Trisphosphate Receptors; Kidney; Lipopolysaccharides; Liver; Male; Microscopy, Electron; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Necrosis; Rats; Rats, Sprague-Dawley; RNA, Messenger; Specific Pathogen-Free Organisms | 2018 |
M1/M2-macrophage Polarization-based Hepatotoxicity in d-galactosamine-induced Acute Liver Injury in Rats.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Liver; Liver Function Tests; Macrophage Activation; Macrophages; Male; Necrosis; Rats, Inbred F344; Receptors, Cell Surface | 2018 |
GABA, γ-Aminobutyric Acid, Protects Against Severe Liver Injury.
Topics: Aminosalicylic Acids; Animals; Benzenesulfonates; Disease Models, Animal; Galactosamine; gamma-Aminobutyric Acid; Humans; Injections, Intraperitoneal; Liver; Liver Failure, Acute; Male; Mice; Mice, Inbred C57BL; Necrosis; Protective Agents; Signal Transduction; STAT3 Transcription Factor; Treatment Outcome; Tumor Necrosis Factor-alpha | 2019 |
Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Bile Acids and Salts; Bile Ducts; Biomarkers; Caspase 3; Cholestasis; Galactosamine; Hepatocytes; HMGB1 Protein; Inflammation; Keratin-18; Ligation; Liver; Liver Diseases; Mice; Mice, Inbred C57BL; MicroRNAs; Necrosis; Neutrophils | 2013 |
Pretreatment with wortmannin alleviates lipopolysaccharide/d-galactosamine-induced acute liver injury.
Topics: Alanine Transaminase; Androstadienes; Animals; Apoptosis; Aspartate Aminotransferases; Autophagy; Chemical and Drug Induced Liver Injury; Cytokines; Galactosamine; Hepatocytes; Immunohistochemistry; In Situ Nick-End Labeling; Inflammation; Lipopolysaccharides; Liver Failure, Acute; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Necrosis; Phosphoinositide-3 Kinase Inhibitors; Wortmannin | 2014 |
Mesenchymal stem cells from the human umbilical cord ameliorate fulminant hepatic failure and increase survival in mice.
Topics: Albumins; alpha-Fetoproteins; Alu Elements; Animals; Antigens, CD; Cell Differentiation; Cord Blood Stem Cell Transplantation; Galactosamine; Humans; Keratin-18; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Failure, Acute; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, SCID; Necrosis; Osteopontin; RNA, Messenger; Survival Rate; Tumor Necrosis Factor-alpha | 2015 |
Development of a rat model of D-galactosamine/lipopolysaccharide induced hepatorenal syndrome.
Topics: Animals; Cytokines; Disease Models, Animal; Galactosamine; Glomerular Filtration Rate; Hepatorenal Syndrome; Kidney; Lipopolysaccharides; Liver; Male; Necrosis; Rats, Sprague-Dawley; Time Factors | 2015 |
The effect of D-galactosamine on lean and steatotic rat hepatocytes in primary culture.
Topics: Animals; Apoptosis; Biomarkers; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Hepatocytes; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Membrane Potential, Mitochondrial; Mitochondria, Liver; Necrosis; Non-alcoholic Fatty Liver Disease; Primary Cell Culture; Rats, Wistar; Reactive Oxygen Species | 2015 |
Caspase Inhibition Prevents Tumor Necrosis Factor-α-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in Vivo and in Vitro.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Autophagy; Caspase Inhibitors; Caspases; Cell Death; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatocytes; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; Models, Biological; Necrosis; NF-kappa B; Tumor Necrosis Factor-alpha | 2016 |
Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure.
Topics: Animals; Carbon Tetrachloride; Caspase 3; Chemical and Drug Induced Liver Injury; Collagen Type IV; Disease Models, Animal; Extracellular Matrix; Galactosamine; Gene Expression Regulation, Enzymologic; Hepatic Stellate Cells; Interleukin-1; Lipopolysaccharides; Liver; Liver Failure, Acute; Longevity; Male; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Necrosis; Rats; Rats, Wistar; RNA, Messenger | 2008 |
Tissue specific activation of the endothelin system in severe acute liver failure.
Topics: Animals; Endothelins; Galactosamine; Inflammation; Kidney; Liver; Liver Failure; Male; Models, Biological; Necrosis; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2008 |
Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Caspase 8; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease Models, Animal; Enzyme Activation; Fas-Associated Death Domain Protein; Galactosamine; Gene Deletion; JNK Mitogen-Activated Protein Kinases; Liver Diseases; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Mutant Proteins; Necrosis; Phosphorylation | 2008 |
Transgenic expression of cyclooxygenase-2 in hepatocytes accelerates endotoxin-induced acute liver failure.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Caspase 3; Caspase 9; Chronic Disease; Cyclooxygenase 2; Galactosamine; Gene Expression; Hemorrhage; Hepatitis; Hepatocytes; Humans; Lipopolysaccharides; Liver Failure, Acute; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 9; Necrosis; Organ Specificity; Poly(ADP-ribose) Polymerases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Signal Transduction; Transgenes; Up-Regulation | 2008 |
Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation.
Topics: Alanine Transaminase; Aldehydes; Animals; Antifibrinolytic Agents; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; Diquat; Disease Models, Animal; DNA Fragmentation; Endotoxins; Galactosamine; Glutathione Disulfide; Hepatocytes; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Liver Diseases; Male; Necrosis; Oxidative Stress; Rats; Rats, Inbred F344; Superoxides; Vitamin K 3 | 2009 |
Role of the perforin/granzyme cell death pathway in D-Gal/LPS-induced inflammatory liver injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Etanercept; Galactosamine; Granzymes; Immunoglobulin G; Interleukin-6; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Pore Forming Cytotoxic Proteins; Receptors, Tumor Necrosis Factor; RNA, Messenger; Signal Transduction; T-Lymphocytes, Cytotoxic; Time Factors; Transaminases; Tumor Necrosis Factor-alpha | 2009 |
A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression.
Topics: Animals; Cell Division; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cysteine Endopeptidases; Fatty Liver; Galactosamine; Gene Expression; Hepatectomy; Hepatocytes; Hydrogen Peroxide; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Liver Failure, Acute; Liver Transplantation; Mice; Mice, Inbred BALB C; Mice, Knockout; Necrosis; Oxidants; PPAR alpha; Reperfusion Injury; Tumor Necrosis Factor alpha-Induced Protein 3 | 2009 |
Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury.
Topics: Acetaminophen; Alanine Transaminase; Albumins; Analgesics, Non-Narcotic; Anesthetics, Local; Animals; Aspartate Aminotransferases; Biomarkers; Bupivacaine; Centrifugation, Density Gradient; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Fibrinogen; Galactosamine; Gene Expression Profiling; Haptoglobins; In Situ Hybridization; Liver; Male; Necrosis; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sensitivity and Specificity; Time Factors | 2010 |
Hoechst-IR: an imaging agent that detects necrotic tissue in vivo by binding extracellular DNA.
Topics: Animals; Base Sequence; Diagnostic Imaging; DNA; Galactosamine; Indoles; Lipopolysaccharides; Macrophages; Mice; Microscopy, Fluorescence; Molecular Structure; Necrosis; Nucleic Acid Conformation | 2010 |
Decreased IgA+ plasma cells and IgA expression in acute liver necrosis mice.
Topics: Acute Disease; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Galactosamine; Immunity, Mucosal; Immunoglobulin A; Interferon-gamma; Intestinal Mucosa; Intestine, Small; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; Necrosis; Plasma Cells; Staining and Labeling | 2010 |
Expression of p53 during apoptosis induced by D-galactosamine and the protective role of PGE1 in cultured rat hepatocytes.
Topics: Alprostadil; Animals; Apoptosis; Cell Death; Cells, Cultured; Cytoplasm; Galactosamine; Hepatocytes; L-Lactate Dehydrogenase; Male; Necrosis; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Proteome; Rats; Rats, Wistar; Tumor Suppressor Protein p53 | 2011 |
Human liver stem cells improve liver injury in a model of fulminant liver failure.
Topics: Adult Stem Cells; Animals; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury; Culture Media, Conditioned; Galactosamine; Humans; Lipopolysaccharides; Liver; Liver Failure, Acute; Liver Regeneration; Male; Mice; Mice, SCID; Multipotent Stem Cells; Necrosis | 2013 |
Hepatoprotective and antioxidant activity of Leucas aspera against D-galactosamine induced liver damage in rats.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Female; Galactosamine; Hexobarbital; Hypnotics and Sedatives; Lamiaceae; Lipid Peroxidation; Liver; Mice; Necrosis; Oxidative Stress; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Silymarin; Sleep; Time Factors | 2012 |
Synergistic effects of antibodies against high-mobility group box 1 and tumor necrosis factor-α antibodies on D-(+)-galactosamine hydrochloride/lipopolysaccharide-induced acute liver failure.
Topics: Alanine Transaminase; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Galactosamine; HMGB1 Protein; Immunohistochemistry; Interleukin-6; Lipopolysaccharides; Liver; Liver Failure, Acute; Mice; Mice, Inbred C57BL; Necrosis; Nitric Oxide Synthase Type II; Protein Interaction Mapping; Tumor Necrosis Factor-alpha | 2013 |
Reactive oxygen as modulator of TNF and fas receptor-mediated apoptosis in vivo: studies with glutathione peroxidase-deficient mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Caspase 3; Caspases; Disease Models, Animal; DNA Fragmentation; Enzyme Precursors; fas Receptor; Galactosamine; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hemorrhage; Liver; Mice; Mice, Inbred Strains; Mice, Knockout; Necrosis; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2002 |
Evaluation of oxidative stress during apoptosis and necrosis caused by D-galactosamine in rat liver.
Topics: Animals; Apoptosis; Ascorbic Acid; Galactosamine; Lipid Peroxides; Liver; Male; Necrosis; Oxidative Stress; Rats; Rats, Wistar; Vitamin E | 2003 |
Oncotic necrosis and caspase-dependent apoptosis during galactosamine-induced liver injury in rats.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Chemical and Drug Induced Liver Injury; Female; Galactosamine; In Situ Nick-End Labeling; Necrosis; Rats; Rats, Sprague-Dawley; Uridine | 2003 |
Protection against liver injury by PGE1 or anti-TNF-alpha is associated with a reduction of TNF-R1 expression in hepatocytes.
Topics: Alanine Transaminase; Alprostadil; Animals; Biomarkers; Disease Models, Animal; Galactosamine; Hepatocytes; Immunohistochemistry; Liver; Liver Failure, Acute; Male; Necrosis; Rats; Rats, Wistar; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2003 |
Role of NF-kappaB activation and nitric oxide expression during PGE protection against d-galactosamine-induced cell death in cultured rat hepatocytes.
Topics: Alprostadil; Animals; Apoptosis; Cell Death; Cells, Cultured; Cysteine Endopeptidases; Cytoprotection; Enzyme Induction; Galactosamine; Hepatocytes; I-kappa B Proteins; Male; Multienzyme Complexes; Necrosis; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; RNA, Messenger | 2004 |
Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals.
Topics: Alanine Transaminase; Animals; Animals, Genetically Modified; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Connexins; Drug Resistance; Female; Galactosamine; Gap Junction beta-1 Protein; Gap Junctions; Gene Dosage; Gene Expression; Genes, Dominant; Liver; Male; Mutation; Necrosis; Rats; Stereoisomerism | 2004 |
The role of histamine H1 receptor and H2 receptor in LPS-induced liver injury.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Caspase 3; Caspase 8; Caspases; Galactosamine; Histamine; Interferon-gamma; Interleukin-10; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Receptors, Histamine H1; Receptors, Histamine H2; Tumor Necrosis Factor-alpha | 2005 |
Lack of protective effect of D-003, a mixture of high-molecular-weight primary acids from sugar cane wax, on liver damage induced by galactosamine in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Fatty Acids; Galactosamine; Hepatocytes; Inclusion Bodies; Lipids; Liver Diseases; Male; Necrosis; Rats; Rats, Sprague-Dawley | 2005 |
Altered protein expression and protein nitration pattern during d-galactosamine-induced cell death in human hepatocytes: a proteomic analysis.
Topics: Apoptosis; Cell Death; Cells, Cultured; Galactosamine; Hepatocytes; Humans; Necrosis; Nitrates; Oxidative Stress; Proteins; Proteomics; Tyrosine | 2005 |
Fibronectin prevents D-galactosamine/lipopolysaccharide-induced lethal hepatic failure in mice.
Topics: Animals; Apoptosis; bcl-X Protein; Cytokines; Female; Fibronectins; Galactosamine; Gene Expression Regulation; Hepatocytes; Lipopolysaccharides; Liver; Liver Failure; Mice; Mice, Inbred BALB C; Necrosis; NF-kappa B; Signal Transduction | 2006 |
Protective effects of antimicrobial peptides derived from the beetle Allomyrina dichotoma defensin on endotoxic shock in mice.
Topics: Agglutination; Animals; Anti-Bacterial Agents; Coleoptera; Defensins; Erythrocytes; Female; Galactosamine; Hemorrhage; Kidney; Lipopolysaccharides; Liver; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Necrosis; Peptides; Salmonella; Shock, Septic; Survival Analysis; Tumor Necrosis Factor-alpha | 2006 |
Inhibitory effect of dimethyl sulfoxide (DMSO) on necrosis and oxidative stress caused by D-galactosamine in the rat liver.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Ascorbic Acid; Aspartate Aminotransferases; Blotting, Western; Dimethyl Sulfoxide; Disease Models, Animal; Free Radical Scavengers; Galactosamine; Liver; Male; Mitogen-Activated Protein Kinases; Necrosis; Oxidative Stress; Rats; Rats, Wistar; Time Factors | 2007 |
Cytochrome c: a non-invasive biomarker of drug-induced liver injury.
Topics: Acetaminophen; Acute Disease; Animals; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury; Cytochromes c; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Hepatocytes; Male; Mitochondria; Necrosis; Rats; Rats, Sprague-Dawley | 2008 |
D-galactosamine-induced liver injury in immunosuppressed mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Immunosuppression Therapy; Inclusion Bodies; Leukocyte Count; Liver; Liver Regeneration; Male; Mice; Mice, Inbred DBA; Microscopy, Electron; Necrosis; Thymectomy; Whole-Body Irradiation | 1984 |
Studies on severe hepatic damage induced by galactosamine.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; DNA; Galactosamine; Liver; Male; Necrosis; Rats; Rats, Inbred Strains; RNA; Uridine Diphosphate Glucose; Uridine Triphosphate | 1982 |
The mechanism of hepatoprotection by epsilon aminocaproic acid and putrescine.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Chemical and Drug Induced Liver Injury; Eflornithine; Galactosamine; Liver Diseases; Necrosis; Ornithine; Ornithine Decarboxylase Inhibitors; Protease Inhibitors; Putrescine; Rats; Rats, Inbred Strains; Urokinase-Type Plasminogen Activator | 1984 |
Late preventive effects on dimethylnitrosamine, thioacetamide or galactosamine-induced liver necrosis of the inhibitor of proteases, phenylmethylsulfonyl fluoride.
Topics: Acetamides; Animals; Dimethylnitrosamine; Drug Evaluation, Preclinical; Galactosamine; Liver; Male; Necrosis; Phenylmethylsulfonyl Fluoride; Rats; Rats, Inbred Strains; Sulfones; Thioacetamide; Time Factors | 1983 |
[Morphological characteristics of D-galactosamine hepatitis].
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Male; Microscopy, Electron; Necrosis; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Influence of aging on the susceptibility of rats to hepatotoxic injury.
Topics: 1-Propanol; Aging; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Endoplasmic Reticulum; Galactosamine; Liver; Male; NADH Dehydrogenase; Necrosis; Propanols; Rats; Rats, Inbred F344 | 1984 |
Cystamine modulation of galactosamine-induced hepatotoxicity.
Topics: Animals; Calcium; Chemical and Drug Induced Liver Injury; Cystamine; Dose-Response Relationship, Drug; Galactosamine; Liver; Liver Diseases; Male; Necrosis; Rats; Rats, Inbred Strains; Uridine | 1984 |
Effects of homologous plasma cross-circulation on liver function in galactosamine-induced hepatic necrosis in rats.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cross Circulation; Galactosamine; Liver Diseases; Liver Function Tests; Male; Mitochondria, Liver; Necrosis; Parabiosis; Plasma Exchange; Rats; Rats, Inbred Strains | 1984 |
The protective effect of polyriboinosinic acid-polyribocytidylic acid against the occurrence of galactosamine-induced liver cell injury in rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carboxymethylcellulose Sodium; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Diseases; Male; Methylcellulose; Necrosis; Peptides; Poly I-C; Polylysine; Rats; Rats, Inbred Strains | 1983 |
Modulation of galactosamine-induced liver injury by some amino acids or Triton WR1339.
Topics: Amino Acids; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Isocitrate Dehydrogenase; Liver Diseases; Male; Necrosis; Polyethylene Glycols; Rats; Rats, Inbred Strains | 1983 |
Cellular transplantation in the treatment of experimental hepatic failure.
Topics: Animals; Bone Marrow Transplantation; Disease Models, Animal; Galactosamine; Hepatectomy; Hypoxia; Liver; Liver Diseases; Liver Transplantation; Necrosis; Rats; Transplantation, Homologous | 1980 |
Alcohol-dependent liver cell necrosis in vitro: a new model.
Topics: Animals; Calcium; Cell Membrane; Cells, Cultured; Drug Synergism; Ethanol; Female; Galactosamine; In Vitro Techniques; Liver; Liver Diseases, Alcoholic; Necrosis; Phalloidine; Rats | 1981 |
Pathological study of chronic D-galactosamine induced hepatitis in mice by administration of adjuvants - an animal model of the chronic active hepatitis.
Topics: Adjuvants, Immunologic; Animals; Blood Proteins; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Liver; Mice; Mice, Inbred C57BL; Necrosis; Organ Size; Spleen | 1981 |
Interleukin-1 and nitric oxide protect against tumor necrosis factor alpha-induced liver injury through distinct pathways.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; DNA; Drug Tolerance; Galactosamine; Humans; Interleukin-1; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Necrosis; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroprusside; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1995 |
Protoberberine alkaloids from Enantia chlorantha therapy of allyl-alcohol- and D-galactosamine-traumatized rats.
Topics: 1-Propanol; Alanine Transaminase; Alkaline Phosphatase; Animals; Berberine Alkaloids; Drug Combinations; Female; Galactosamine; Liver; Liver Function Tests; Necrosis; Plants, Medicinal; Propanols; Rats | 1993 |
Similar cytokine but different coagulation responses to lipopolysaccharide injection in D-galactosamine-sensitized versus nonsensitized rats.
Topics: Animals; Bacterial Toxins; Disseminated Intravascular Coagulation; Dose-Response Relationship, Drug; Endotoxins; Escherichia coli; Galactosamine; Intestinal Diseases; Lipopolysaccharides; Liver Diseases; Lung Diseases; Male; Necrosis; Rats; Rats, Sprague-Dawley; Shock, Septic; Tumor Necrosis Factor-alpha | 1994 |
Mechanisms and mediators in hepatic necrosis.
Topics: Animals; Cell Hypoxia; Endotoxins; Galactosamine; Kupffer Cells; Liver; Necrosis; Nitric Oxide; Rats; Reactive Oxygen Species | 1993 |
Hepatoprotective effects of emodin from Ventilago leiocarpa.
Topics: Acetates; Analysis of Variance; Animals; Carbon Tetrachloride; Chemical Fractionation; Chloroform; Emodin; Enzyme Inhibitors; Galactosamine; Hyalin; Kupffer Cells; Liver; Lymphocytes; Male; Necrosis; Plant Extracts; Rats; Rats, Wistar | 1996 |
[The effect of cytokines on the liver necrosis].
Topics: Animals; Bilirubin; Galactosamine; Interferon-gamma; Interleukin-1; Liver; Male; Mice; Mice, Inbred BALB C; Necrosis; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1996 |
Quinine inhibits release of tumor necrosis factor, apoptosis, necrosis and mortality in a murine model of septic liver failure.
Topics: Animals; Apoptosis; DNA; Galactosamine; Lipopolysaccharides; Liver; Liver Failure; Male; Mice; Mice, Inbred BALB C; Necrosis; Potassium Channels; Quinine; Rats; Salmonella; Sepsis; Tumor Necrosis Factor-alpha | 1995 |
Protective effect of celosian, an acidic polysaccharide, on chemically and immunologically induced liver injuries.
Topics: Animals; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzymes; Galactosamine; Glycyrrhetinic Acid; Glycyrrhizic Acid; Lipid Peroxidation; Lipid Peroxides; Lipopolysaccharides; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Necrosis; Plant Extracts; Polysaccharides; Rats; Rats, Sprague-Dawley; Seeds; Tumor Necrosis Factor-alpha | 1996 |
DNA fragmentation in mouse organs during endotoxic shock.
Topics: Animals; Apoptosis; Disease Models, Animal; DNA Fragmentation; Female; Galactosamine; Lipopolysaccharides; Liver; Mice; Mice, Inbred BALB C; Microscopy, Electron; Necrosis; Nitric Oxide; Protein Biosynthesis; Shock, Septic; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1996 |
Changes in taurine as an indicator of hepatic dysfunction and biochemical perturbations. Studies in vivo and in vitro.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cells, Cultured; Clenbuterol; Galactosamine; Glutathione; Ketones; Liver; Liver Diseases; Male; Maleates; Necrosis; Phenobarbital; Rats; Rats, Sprague-Dawley; Taurine; Thioacetamide | 1996 |
Galactosamine-induced fulminant hepatic necrosis in unanesthetized canines.
Topics: Anesthesia; Animals; Artificial Organs; Disease Models, Animal; Dogs; Evaluation Studies as Topic; Female; Galactosamine; Liver; Liver Failure; Male; Necrosis | 1997 |
[The effect of tumor necrosis factor alpha on hepatic necrosis in viral hepatitis].
Topics: Adult; Aged; Animals; Female; Galactosamine; Hepatic Encephalopathy; Hepatitis, Animal; Hepatitis, Viral, Human; Humans; Immunohistochemistry; Liver; Male; Middle Aged; Necrosis; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 1996 |
Apoptosis of murine hepatocytes induced by high doses of galactosamine.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Galactosamine; Histocytochemistry; Injections, Intraperitoneal; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Necrosis; Time Factors | 1997 |
Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alpha-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model.
Topics: Animals; Apoptosis; Bacterial Toxins; Caspase 3; Caspases; Cysteine Endopeptidases; Disease Models, Animal; Endotoxins; Enzyme Activation; Galactosamine; Liver; Male; Mice; Mice, Inbred C3H; Necrosis; Neutrophils; Salmonella; Shock, Septic; Time Factors; Tumor Necrosis Factor-alpha | 1998 |
Ultrastructural study of development of hepatic necrosis induced by TNF-alpha and D-galactosamine.
Topics: Animals; Galactosamine; Kupffer Cells; Liver; Liver Failure, Acute; Male; Mice; Mice, Inbred ICR; Microscopy, Electron; Microscopy, Electron, Scanning; Necrosis; Time Factors; Tumor Necrosis Factor-alpha | 1998 |
The beneficial effect of phosphocreatine accumulation in the creatine kinase transgenic mouse liver in endotoxin-induced hepatic cell death.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Brain; Creatine Kinase; Energy Metabolism; Galactosamine; Isoenzymes; Lipopolysaccharides; Liver; Mice; Mice, Transgenic; Necrosis; Phosphocreatine; Rats; Sepsis; Tumor Necrosis Factor-alpha | 1998 |
Effect of HD-03--a herbal formulation in galactosamine-induced hepatopathy in rats.
Topics: Animals; Bile Ducts; Chemical and Drug Induced Liver Injury; Female; Galactosamine; Liver; Liver Function Tests; Magnoliopsida; Male; Necrosis; Phytotherapy; Plant Extracts; Rats; Rats, Wistar | 2000 |
The major acute-phase protein, serum amyloid P component, in mice is not involved in endogenous resistance against tumor necrosis factor alpha-induced lethal hepatitis, shock, and skin necrosis.
Topics: Animals; Galactosamine; Hepatitis, Animal; Interleukin-1; Mice; Mice, Inbred C57BL; Necrosis; Serum Amyloid P-Component; Skin; Systemic Inflammatory Response Syndrome; Tumor Necrosis Factor-alpha | 2000 |
Genetic determinants of lipopolysaccharide and D-galactosamine-mediated hepatocellular apoptosis and lethality.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Galactosamine; Humans; Lipopolysaccharides; Liver; Liver Diseases; Longevity; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, Transgenic; Necrosis; Recombinant Proteins; Species Specificity; Tumor Necrosis Factor-alpha | 2001 |
PGE1 protection against apoptosis induced by D-galactosamine is not related to the modulation of intracellular free radical production in primary culture of rat hepatocytes.
Topics: Alprostadil; Animals; Apoptosis; Caspase 3; Caspases; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Flow Cytometry; Free Radicals; Galactosamine; Glutathione; Hepatocytes; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Male; Membrane Potentials; Mitochondria; Necrosis; Platelet Aggregation Inhibitors; Ploidies; Rats; Rats, Wistar; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances | 2002 |
Pirfenidone suppresses tumor necrosis factor-alpha, enhances interleukin-10 and protects mice from endotoxic shock.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Galactosamine; Interferon-gamma; Interleukin-10; Interleukin-12; Lipopolysaccharides; Liver; Liver Failure; Mice; Mice, Inbred C57BL; Necrosis; Pyridones; Shock, Septic; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2002 |
Partial purification of a serum factor that causes necrosis of tumors.
Topics: Alpha-Globulins; Animals; BCG Vaccine; Blood Proteins; Endotoxins; Fibrosarcoma; Galactosamine; Glycoproteins; Methylcholanthrene; Mice; Molecular Weight; Mycobacterium bovis; Necrosis; Neoplasms, Experimental; Sialic Acids | 1976 |
Serum alpha-fetoprotein. A prognostic indicator of liver-cell necrosis and regeneration following experimental injury by galactosamine in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Hepatitis, Viral, Human; Humans; Liver; Liver Regeneration; Male; Necrosis; Prognosis; Rats; Time Factors | 1976 |
On the pathogenesis of galactosamine hepatitis. Indications of extrahepatocellular mechanisms responsible for liver cell death.
Topics: Animals; Chemical and Drug Induced Liver Injury; Colectomy; Complement System Proteins; Endotoxins; Galactosamine; Male; Mast Cells; Mice; Mice, Inbred Strains; Necrosis; Rats | 1978 |
Biochemical, hematological and histological changes in a fulminant hepatic failure rat model for artificial liver assessment.
Topics: Animals; Artificial Organs; Aspartate Aminotransferases; Bilirubin; Charcoal; Chemical and Drug Induced Liver Injury; Cross Circulation; Galactosamine; Hemoperfusion; Liver; Liver Diseases; Male; Necrosis; Prothrombin Time; Rats | 1979 |
Modification of D-galactosamine-induced liver injury in the rat by spironolactone.
Topics: Animals; Aspartate Aminotransferases; Bile Acids and Salts; Galactosamine; Injections, Intraperitoneal; Liver; Male; Necrosis; Rats; Spironolactone | 1979 |
Synergistic action of hepatocyte membrane defect and activated complement system in liver cell death--an experimental approach to fulminant hepatic failure.
Topics: Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Complement C3; Complement System Proteins; Drug Synergism; Endotoxins; Galactosamine; Necrosis; Rats | 1978 |
D-galactosamine hepatotoxocity. V. Role of free fatty acids in the pathogenesis of fatty liver.
Topics: Fasting; Fatty Acids, Nonesterified; Fatty Liver; Galactosamine; Lipid Mobilization; Liver; Necrosis; Triglycerides | 1978 |
Protective role of hydrocortisone on galactosamine-induced hepatitis into rats.
Topics: Animals; Female; Galactosamine; Hepatitis, Animal; Hydrocortisone; Liver; Liver Glycogen; Male; Necrosis; Rats | 1977 |
Galactosamine- "hepatitis" in rats with different phagocytic activity of liver RES.
Topics: Animals; Carbon; Chemical and Drug Induced Liver Injury; Galactosamine; Ink; Kupffer Cells; Liver; Mononuclear Phagocyte System; Necrosis; Phagocytosis; Premedication; Rats; Rats, Inbred Strains; Shwartzman Phenomenon; Time Factors | 1975 |
The biochemical pathology of liver cell necrosis.
Topics: Animals; Calcium; Cell Membrane; Cell Survival; Chemical and Drug Induced Liver Injury; Galactosamine; Humans; Liver; Lysosomes; Mitochondria, Liver; Necrosis; Protein Biosynthesis; Rats; RNA; Uridine | 1975 |
[Proceedings: Inhibition of D-galactosamine-induced damage to liver cells through D-fructose administration].
Topics: Animals; Fructose; Galactosamine; Liver; Liver Diseases; Necrosis; Rats | 1975 |
Effects of ammonia intoxication and liver injury on rat brain glutamate-dehydrogenase and glutaminase activity.
Topics: Ammonia; Animals; Brain; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Galactosamine; Glutamate Dehydrogenase; Glutaminase; Necrosis; Neurologic Manifestations; Rats | 1975 |
Modification of the hepatotoxicity of D-galactosamine in the rat by cycloheximide.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cycloheximide; Galactosamine; Liver; Liver Diseases; Necrosis; Protein Biosynthesis; Rats; Triglycerides | 1976 |
Ongoing hepatocellular regeneration and resiliency toward galactosamine hepatotoxicity.
Topics: Aging; Alanine Transaminase; Animals; Aspartate Aminotransferases; Autoradiography; Chemical and Drug Induced Liver Injury; DNA; Female; Galactosamine; Liver; Liver Diseases; Liver Glycogen; Liver Regeneration; Male; Necrosis; Pregnancy; Rats; Rats, Sprague-Dawley; Time Factors; Uracil Nucleotides | 1992 |
Immunohistochemical study of extracellular matrix in acute galactosamine hepatitis in rats.
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Collagen; Extracellular Matrix; Fibronectins; Galactosamine; Immunohistochemistry; Laminin; Liver; Male; Necrosis; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Staining and Labeling | 1992 |
Hepatic stimulator substance from human fetal liver for treatment of experimental hepatic failure.
Topics: Animals; Fetus; Galactosamine; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Liver; Liver Failure; Liver Regeneration; Necrosis; Peptides; Rats; Rats, Wistar | 1992 |
Rat hepatocyte nodules are resistant to the necrogenic effect of D-galactosamine.
Topics: Animals; Drug Resistance; Galactosamine; Liver; Male; Necrosis; Rats; Rats, Wistar | 1992 |
Involvement of activated polymorphonuclear leukocytes in galactosamine-induced hepatic injury in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Male; Necrosis; Neutrophils; Rats; Rats, Inbred Strains; Superoxides | 1991 |
FK 506 modulates D-galactosamine-induced hepatitis in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Galactosamine; Hepatitis, Animal; Liver; Liver Function Tests; Male; Necrosis; Rats; Rats, Inbred Strains; Tacrolimus; Time Factors | 1991 |
N1-methylnicotinamide level in the blood after nicotinamide loading as further evidence for malignant tumor burden.
Topics: Animals; Carbon Tetrachloride Poisoning; Cells, Cultured; DNA Replication; Galactosamine; Inflammation; Liver; Male; Methyltransferases; Mice; Mice, Inbred Strains; Necrosis; Neoplasms, Experimental; Niacinamide; Nicotinamide N-Methyltransferase | 1991 |
Human hepatic regenerative stimulator substance: partial purification and biological characterization of hepatic stimulator substance from human fetal liver cells.
Topics: Animals; Cell Division; Chemical and Drug Induced Liver Injury; Female; Fetus; Galactosamine; Growth Substances; Hepatectomy; Humans; Liver; Liver Diseases; Liver Regeneration; Male; Mice; Mice, Inbred Strains; Necrosis; Rats; Rats, Inbred Strains | 1990 |
Immunopathology of acute galactosamine hepatitis in rats.
Topics: Acute Disease; Animals; Antibodies, Monoclonal; Chemical and Drug Induced Liver Injury; Galactosamine; Immunohistochemistry; Liver; Liver Regeneration; Macrophages; Male; Necrosis; Rats; Rats, Inbred Strains; T-Lymphocytes, Cytotoxic | 1990 |
[Protective effects of DBcAMP on acute liver failure induced by D-galactosamine in rats].
Topics: Acute Disease; Adenosine Triphosphate; Animals; Blood Glucose; Bucladesine; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Circulation; Liver Diseases; Liver Function Tests; Male; Necrosis; Rats; Rats, Inbred Strains | 1989 |
[Role of singlet oxygen in pathogenesis of liver injury in rats treated with D-galactosamine].
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Lipid Peroxidation; Liver; Liver Diseases; Luminescent Measurements; Male; Necrosis; Oxygen; Rats; Rats, Inbred Strains; Singlet Oxygen; Vitamin E | 1989 |
Changes in endogenous prostaglandin levels during D-galactosamine-induced liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Galactosamine; Indomethacin; Liver Diseases; Male; Necrosis; Prostaglandins; Rats; Rats, Inbred Strains | 1989 |
[Effects of preliminary fasting on the development of D-galactosamine-induced acute lesion of the liver in rats].
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Fasting; Galactosamine; Glutarates; Glutathione; Hyperplasia; Hypertrophy; Liver; Male; Necrosis; Rats; Rats, Inbred Strains | 1989 |
The effect of nonviral liver damage on the T-lymphocyte helper/suppressor ratio.
Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Leukocyte Count; Necrosis; Orotic Acid; Rats; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory | 1988 |
[Relation of serum glutathione S-transferase activity and pathologic abnormalities of the liver].
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione Transferase; Hepatitis, Viral, Animal; Hepatitis, Viral, Human; Humans; Liver; Necrosis; Rabbits | 1988 |
Effect of prostacyclin (PGI2) and a prostaglandin analogue BW 245C on galactosamine-induced hepatic necrosis.
Topics: Acetylglucosaminidase; Animals; Aspartate Aminotransferases; Cathepsin D; Epoprostenol; Galactosamine; Hydantoins; Liver; Male; Necrosis; Nucleotides, Cyclic; Rats; Rats, Inbred Strains | 1986 |
[Galactosamine-induced acute liver failure in the guinea pig--spontaneous course and controlled study conditions].
Topics: Acute Disease; Animals; Blood Glucose; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Guinea Pigs; Hepatic Encephalopathy; Liver; Liver Function Tests; Male; Necrosis | 1986 |
[Experimental study on the role of endotoxin in the mechanism of galactosamine-induced liver injury].
Topics: Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Liver; Liver Diseases; Male; Mitochondria, Liver; Necrosis; Oxygen Consumption; Rats; Rats, Inbred Strains | 1986 |
Chronic liver disease animal model for evaluation of artificial liver support systems.
Topics: Animals; Body Weight; Chronic Disease; Disease Models, Animal; Dogs; Fibrinogen; Galactosamine; Hepatitis, Chronic; Liver Diseases; Male; Necrosis; Partial Thromboplastin Time; Prothrombin Time | 1985 |
Late preventive effects of several anticalmodulin drugs on galactosamine-induced liver necrosis.
Topics: Animals; Calmodulin; Galactosamine; Imipramine; Liver; Male; Necrosis; Pimozide; Rats; Thioridazine; Trifluoperazine | 1985 |
Antinecrotic effect of 3-palmitoyl-(+)-catechin against liver damage induced by galactosamine or ethanol in the rat.
Topics: Animals; Benzopyrans; Catechin; Chemical and Drug Induced Liver Injury; Ethanol; Galactosamine; Hypoxia; Liver Diseases; Male; Necrosis; Rats; Rats, Inbred Strains | 1985 |
Structural requirements for cytoprotective agents in galactosamine-induced hepatic necrosis.
Topics: Animals; Calcium; Chelating Agents; Chemical and Drug Induced Liver Injury; Cystamine; Cysteamine; Galactosamine; Liver Diseases; Male; Necrosis; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1985 |
The effect of Cernitins on galactosamine-induced hepatic injury in rat.
Topics: Animals; Dose-Response Relationship, Drug; Fatty Liver; Galactosamine; Liver; Male; Necrosis; Plant Extracts; Pollen; Rats; Rats, Inbred Strains; Secale | 1985 |
D-galactosamine hepatotoxicity. 3. Normoactive smooth endoplasmic reticulum and modification by phenobarbital.
Topics: Animals; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Endoplasmic Reticulum; Female; Galactosamine; Hyperplasia; Liver; Microscopy, Electron; Necrosis; Pentobarbital; Phenobarbital; Rats; Sleep; Time Factors | 1973 |
D-galactosamine and acute liver cell injury.
Topics: Animals; Cell Nucleolus; Cell Nucleus; Centrifugation; Chemical and Drug Induced Liver Injury; DNA-Directed RNA Polymerases; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Female; Galactosamine; Glycoproteins; Guinea Pigs; Hexosamines; Liver; Mice; Microscopy, Electron; Necrosis; Protein Biosynthesis; Rabbits; Rats; Ribosomes; RNA; Uracil Nucleotides; Uridine; Uridine Diphosphate Sugars | 1973 |
[Haemostasis during galactosamine hepatitis].
Topics: Animals; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Factor V; Factor VIII; Galactosamine; Hemostasis; Hexosamines; Necrosis; Prothrombin; Rabbits | 1972 |
Acute toxic effects of D-galactosamine on human embryo liver cells in tissue culture.
Topics: Cell Nucleus; Cells, Cultured; Embryo, Mammalian; Fibroblasts; Galactosamine; Galactosemias; Glucosamine; Hexosamines; Humans; In Vitro Techniques; Liver; Microscopy, Fluorescence; Necrosis; Triglycerides | 1972 |