Proteins > Cyclin-K
Page last updated: 2024-08-07 23:06:41

Cyclin-K

A cyclin-K that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75909]

Synonyms

Research

Bioassay Publications (11)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (54.55)24.3611
2020's5 (45.45)2.80

Compounds (7)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
staurosporineHomo sapiens (human)IC500.094855
alvocidibHomo sapiens (human)IC501.370011
palbociclibHomo sapiens (human)IC501.207011
14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaeneHomo sapiens (human)IC500.003011
abemaciclibHomo sapiens (human)IC500.065011
dinaciclibHomo sapiens (human)IC500.022733
THZ531Homo sapiens (human)IC500.265666

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
cyclin-dependent protein serine/threonine kinase activitymolecular functionCyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
RNA polymerase II CTD heptapeptide repeat kinase activitymolecular functionCatalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II. [EC:2.7.11.23, GOC:mah, PMID:28248323]
protein kinase bindingmolecular functionBinding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
cyclin-dependent protein serine/threonine kinase activator activitymolecular functionBinds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. [GOC:dph, PMID:2569363, PMID:3322810]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 3 target(s):

TargetCategoryDefinition
cyclin K-CDK12 complexcellular componentA protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [PMID:22012619]
cyclin K-CDK13 complexcellular componentA protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [PMID:22012619]
cyclin/CDK positive transcription elongation factor complexcellular componentA transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit. [GOC:bhm, GOC:vw, PMID:10766736, PMID:16721054, PMID:17079683, PMID:19328067, PMID:7759473]

Involved In

This protein is involved in 8 target(s):

TargetCategoryDefinition
regulation of cyclin-dependent protein serine/threonine kinase activitybiological processAny process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. [GOC:go_curators, GOC:pr]
transcription by RNA polymerase IIbiological processThe synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382]
regulation of signal transductionbiological processAny process that modulates the frequency, rate or extent of signal transduction. [GOC:sm]
positive regulation of transcription elongation by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. [GOC:mah, GOC:txnOH]
negative regulation by host of viral genome replicationbiological processA process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral genome replication. [GOC:jl]
cell divisionbiological processThe process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr]
regulation of transcription by RNA polymerase IIbiological processAny process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
positive regulation of DNA-templated transcription, elongationbiological processAny process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. [GOC:mah, GOC:txnOH]