Page last updated: 2024-08-07 13:40:11
G-protein coupled bile acid receptor 1
A G-protein coupled bile acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDU6]
Synonyms
G-protein coupled receptor GPCR19;
hGPCR19;
Membrane-type receptor for bile acids;
M-BAR;
hBG37;
BG37
Research
Bioassay Publications (25)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 17 (68.00) | 24.3611 |
| 2020's | 5 (20.00) | 2.80 |
Compounds (55)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| magnolol | Homo sapiens (human) | Ki | 1.4400 | 1 | 1 |
| honokiol | Homo sapiens (human) | Ki | 5.6100 | 1 | 1 |
| sr141716 | Homo sapiens (human) | Ki | 0.9000 | 1 | 1 |
| cp-55,940 | Homo sapiens (human) | Ki | 0.0014 | 1 | 1 |
| 4-methoxyhonokiol | Homo sapiens (human) | Ki | 0.0440 | 1 | 1 |
| cholic acid | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| pf 5901 | Homo sapiens (human) | EC50 | 2.5000 | 1 | 1 |
| androsterone | Homo sapiens (human) | EC50 | 6.2200 | 1 | 1 |
| etiocholanolone | Homo sapiens (human) | EC50 | 3.7600 | 1 | 1 |
| dehydroepiandrosterone | Homo sapiens (human) | EC50 | 3.3300 | 1 | 1 |
| taurocholic acid | Homo sapiens (human) | EC50 | 4.9500 | 1 | 1 |
| lithocholic acid | Homo sapiens (human) | EC50 | 2.5180 | 5 | 5 |
| chenodeoxycholic acid | Homo sapiens (human) | EC50 | 15.4820 | 10 | 10 |
| glycocholic acid | Homo sapiens (human) | EC50 | 13.6000 | 1 | 1 |
| oleanolic acid | Homo sapiens (human) | EC50 | 2.2500 | 1 | 1 |
| dihydrotestosterone | Homo sapiens (human) | EC50 | 4.4900 | 1 | 1 |
| glycochenodeoxycholic acid | Homo sapiens (human) | EC50 | 3.8800 | 1 | 1 |
| dehydroepiandrosterone sulfate | Homo sapiens (human) | EC50 | 127.0000 | 1 | 1 |
| 5 alpha-androstane-3 alpha,17 beta-diol | Homo sapiens (human) | EC50 | 7.0100 | 1 | 1 |
| ursodeoxycholic acid | Homo sapiens (human) | EC50 | 46.2633 | 3 | 3 |
| ursolic acid | Homo sapiens (human) | EC50 | 1.4300 | 1 | 1 |
| betulinic acid | Homo sapiens (human) | EC50 | 1.0400 | 1 | 1 |
| platanic acid | Homo sapiens (human) | EC50 | 3.1100 | 1 | 1 |
| betulin | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| alpha-amyrin | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| betulinic acid methyl ester | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| arjunolic acid | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| friedelin | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| lupenone | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| uvaol | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| cholanic acid | Homo sapiens (human) | EC50 | 6.0800 | 1 | 1 |
| 5-alpha-dihydroprogesterone | Homo sapiens (human) | EC50 | 0.2900 | 1 | 1 |
| methyl lithocholate | Homo sapiens (human) | EC50 | 0.5900 | 1 | 1 |
| glycolithocholic acid | Homo sapiens (human) | EC50 | 0.5400 | 1 | 1 |
| asiatic acid | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| taurohyodeoxycholic acid | Homo sapiens (human) | EC50 | 24.2000 | 1 | 1 |
| betulonic acid | Homo sapiens (human) | EC50 | 4.7100 | 1 | 1 |
| 24-norursodeoxycholic acid | Homo sapiens (human) | EC50 | 47.2000 | 1 | 1 |
| cholic acid | Homo sapiens (human) | EC50 | 14.6383 | 6 | 6 |
| deoxycholic acid | Homo sapiens (human) | EC50 | 1.2500 | 1 | 1 |
| epietiocholanolone | Homo sapiens (human) | EC50 | 2.6200 | 1 | 1 |
| taurochenodeoxycholic acid | Homo sapiens (human) | EC50 | 11.2633 | 3 | 3 |
| taurolithocholic acid | Homo sapiens (human) | EC50 | 0.6181 | 4 | 4 |
| epiandrosterone | Homo sapiens (human) | EC50 | 3.2000 | 1 | 1 |
| obeticholic acid | Homo sapiens (human) | EC50 | 4.7990 | 8 | 8 |
| sulfolithocholic acid | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| sodium taurodeoxycholate | Homo sapiens (human) | EC50 | 3.4567 | 3 | 3 |
| glycodeoxycholic acid | Homo sapiens (human) | EC50 | 1.1800 | 1 | 1 |
| hyodeoxycholic acid | Homo sapiens (human) | EC50 | 31.6000 | 1 | 1 |
| 3-ketolithocholic acid | Homo sapiens (human) | EC50 | 0.2700 | 1 | 1 |
| loa | Homo sapiens (human) | EC50 | 102.0000 | 1 | 1 |
| ursodoxicoltaurine | Homo sapiens (human) | EC50 | 61.8833 | 3 | 3 |
| glycoursodeoxycholic acid | Homo sapiens (human) | EC50 | 33.9000 | 1 | 1 |
| beta-Elemonic acid | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| int-777 | Homo sapiens (human) | EC50 | 2.2907 | 12 | 12 |
| unipr129 | Homo sapiens (human) | EC50 | 4.0000 | 1 | 1 |
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| bile acid receptor activity | molecular function | Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile. [GOC:bf, PMID:10334992, PMID:12718893] |
| G protein-coupled bile acid receptor activity | molecular function | Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, PMID:12524422] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| receptor complex | cellular component | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| cell surface bile acid receptor signaling pathway | biological process | The series of molecular signals initiated by binding of a bile acid to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, PMID:12419312, PMID:19442546] |
| positive regulation of ERK1 and ERK2 cascade | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah] |
| cellular response to bile acid | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002] |
| positive regulation of cholangiocyte proliferation | biological process | Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:24434010] |
| regulation of bicellular tight junction assembly | biological process | Any process that modulates the frequency, rate or extent of tight junction assembly. [GOC:BHF] |
| G protein-coupled receptor signaling pathway | biological process | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] |