A lysine-specific demethylase 5D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BY66]
EC 1.14.11.67;
Histocompatibility Y antigen;
H-Y;
Histone demethylase JARID1D;
Jumonji/ARID domain-containing protein 1D;
Protein SmcY;
[histone H3]-trimethyl-L-lysine(4) demethylase 5D
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2,4-pyridinedicarboxylic acid | Homo sapiens (human) | IC50 | 8.6000 | 1 | 8 |
| oxalylglycine | Homo sapiens (human) | IC50 | 17.0633 | 1 | 9 |
| 3-[[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-4-pyrimidinyl]amino]propanoic acid | Homo sapiens (human) | IC50 | 16.9300 | 1 | 7 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| DNA binding | molecular function | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| histone demethylase activity | molecular function | Catalysis of the removal of a methyl group from a histone. [GOC:mah] |
| histone H3K4 demethylase activity | molecular function | Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein. [GOC:mah] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| nuclear androgen receptor binding | molecular function | Binding to a nuclear androgen receptor. [GOC:ai] |
| histone H3K4me/H3K4me2/H3K4me3 demethylase activity | molecular function | Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:17550896, PMID:22473470] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| fibrillar center | cellular component | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. [PMID:10754561] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| chromatin | cellular component | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130] |
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| T cell antigen processing and presentation | biological process | The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GOC:add, PMID:11417857, PMID:15120183] |
| regulation of androgen receptor signaling pathway | biological process | Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway. [GOC:dph] |
| regulation of DNA-templated transcription | biological process | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH] |
| chromatin remodeling | biological process | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] |