Lysine-specific demethylase 5D

A lysine-specific demethylase 5D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BY66]

Synonyms

EC 1.14.11.67;
Histocompatibility Y antigen;
H-Y;
Histone demethylase JARID1D;
Jumonji/ARID domain-containing protein 1D;
Protein SmcY;
[histone H3]-trimethyl-L-lysine(4) demethylase 5D

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (3)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2,4-pyridinedicarboxylic acid	Homo sapiens (human)	IC50	8.6000	1	8
oxalylglycine	Homo sapiens (human)	IC50	17.0633	1	9
3-[[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-4-pyrimidinyl]amino]propanoic acid	Homo sapiens (human)	IC50	16.9300	1	7

Enables

This protein enables 7 target(s):

Target	Category	Definition
DNA binding	molecular function	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
histone demethylase activity	molecular function	Catalysis of the removal of a methyl group from a histone. [GOC:mah]
histone H3K4 demethylase activity	molecular function	Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein. [GOC:mah]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
nuclear androgen receptor binding	molecular function	Binding to a nuclear androgen receptor. [GOC:ai]
histone H3K4me/H3K4me2/H3K4me3 demethylase activity	molecular function	Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:17550896, PMID:22473470]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
fibrillar center	cellular component	A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. [PMID:10754561]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
chromatin	cellular component	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]

Involved In

This protein is involved in 4 target(s):

Target	Category	Definition
T cell antigen processing and presentation	biological process	The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GOC:add, PMID:11417857, PMID:15120183]
regulation of androgen receptor signaling pathway	biological process	Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway. [GOC:dph]
regulation of DNA-templated transcription	biological process	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
chromatin remodeling	biological process	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]

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