Page last updated: 2024-08-07 12:52:45
Proto-oncogene tyrosine-protein kinase LCK
A tyrosine-protein kinase Lck that is encoded in the genome of mouse. [OMA:P06240, PRO:CNA]
Synonyms
EC 2.7.10.2;
Leukocyte C-terminal Src kinase;
LSK;
Lymphocyte cell-specific protein-tyrosine kinase;
p56-LCK
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (11)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 1-NA-PP1 | Mus musculus (house mouse) | IC50 | 0.6600 | 1 | 1 |
| ag 1879 | Mus musculus (house mouse) | IC50 | 0.0310 | 1 | 1 |
| zm 336372 | Mus musculus (house mouse) | IC50 | 0.5700 | 1 | 1 |
| repsox | Mus musculus (house mouse) | IC50 | 16.0000 | 1 | 1 |
| dasatinib | Mus musculus (house mouse) | IC50 | 0.0004 | 1 | 1 |
| dasatinib | Mus musculus (house mouse) | Ki | 0.0001 | 1 | 1 |
| 1-tert-butyl-3-naphthalen-1-ylmethyl-1h-pyrazolo(3,4-d)pyrimidin-4-ylemine | Mus musculus (house mouse) | IC50 | 0.4600 | 1 | 1 |
| su 6656 | Mus musculus (house mouse) | IC50 | 0.1500 | 1 | 1 |
| N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide | Mus musculus (house mouse) | Ki | 5.4000 | 1 | 1 |
| gw 2580 | Mus musculus (house mouse) | IC50 | 10.0000 | 1 | 1 |
| cgp 57380 | Mus musculus (house mouse) | IC50 | 2.5000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| a 770041 | Mus musculus (house mouse) | EC50 | 0.0780 | 1 | 1 |