Progesterone receptor

A progesterone receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06401]

Synonyms

PR;
Nuclear receptor subfamily 3 group C member 3

Research

Bioassay Publications (94)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	10 (10.64)	18.2507
2000's	45 (47.87)	29.6817
2010's	35 (37.23)	24.3611
2020's	4 (4.26)	2.80

Compounds (43)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bicalutamide	Homo sapiens (human)	IC50	1.8190	1	1
raloxifene	Homo sapiens (human)	IC50	0.1000	1	1
prednisolone	Homo sapiens (human)	IC50	6.0133	6	6
prednisolone	Homo sapiens (human)	Ki	5.4286	7	7
spironolactone	Homo sapiens (human)	IC50	3.3400	5	5
spironolactone	Homo sapiens (human)	Ki	0.3997	1	1
norethindrone	Homo sapiens (human)	IC50	0.0032	1	1
norethindrone	Homo sapiens (human)	Ki	0.0019	1	1
medroxyprogesterone acetate	Homo sapiens (human)	IC50	2.5081	4	4
medroxyprogesterone acetate	Homo sapiens (human)	Ki	0.0005	8	8
cyproterone acetate	Homo sapiens (human)	IC50	1.0000	1	1
dihydrotestosterone	Homo sapiens (human)	IC50	7.3000	1	1
promegestone	Homo sapiens (human)	IC50	0.0002	1	1
mifepristone	Homo sapiens (human)	IC50	0.1347	42	45
mifepristone	Homo sapiens (human)	Ki	0.0045	13	13
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol	Homo sapiens (human)	IC50	50.0004	2	2
hydroxyflutamide	Homo sapiens (human)	IC50	2.0130	1	1
fulvestrant	Homo sapiens (human)	IC50	50.0001	2	2
ulipristal acetate	Homo sapiens (human)	IC50	0.0002	1	1
ru 58841	Homo sapiens (human)	IC50	1.0000	1	1
metribolone	Homo sapiens (human)	Ki	0.0005	1	1
eplerenone	Homo sapiens (human)	IC50	12.0000	5	5
eplerenone	Homo sapiens (human)	Ki	19.9526	1	1
fluticasone propionate	Homo sapiens (human)	IC50	0.0210	1	1
tamoxifen	Homo sapiens (human)	IC50	50.0644	2	2
tanaproget	Homo sapiens (human)	IC50	0.0005	1	1
pulmicort	Homo sapiens (human)	IC50	0.0280	1	1
baicalein	Homo sapiens (human)	IC50	15.0000	1	1
afimoxifene	Homo sapiens (human)	IC50	0.1000	1	1
gw 5638	Homo sapiens (human)	IC50	51.9905	2	2
onapristone	Homo sapiens (human)	IC50	0.0026	6	6
onapristone	Homo sapiens (human)	Ki	0.0180	5	5
pregna-4,17-diene-3,16-dione	Homo sapiens (human)	IC50	50.6000	2	2
pregna-4,17-diene-3,16-dione	Homo sapiens (human)	Ki	0.2010	1	1
pregna-4,17-diene-3,16-dione, (17z)-isomer	Homo sapiens (human)	IC50	0.7400	1	1
pregna-4,17-diene-3,16-dione, (17z)-isomer	Homo sapiens (human)	Ki	0.2240	1	1
lonaprisan	Homo sapiens (human)	IC50	0.0000	2	2
asoprisnil	Homo sapiens (human)	IC50	0.0003	3	3
gw 7604	Homo sapiens (human)	IC50	15.8174	2	2
zk 216348	Homo sapiens (human)	IC50	0.0195	2	2
fluticasone furoate	Homo sapiens (human)	IC50	0.0210	1	1
way-362450	Homo sapiens (human)	IC50	10.0000	1	1
metapristone	Homo sapiens (human)	IC50	0.0001	3	3
lgd 2226	Homo sapiens (human)	Ki	1.0000	1	1
way 252623	Homo sapiens (human)	IC50	1.0000	1	1
pf 998425	Homo sapiens (human)	IC50	10.0000	1	1
pf-03882845	Homo sapiens (human)	IC50	0.4160	2	2
bay 94-8862	Homo sapiens (human)	IC50	10.0000	1	1
azd9496	Homo sapiens (human)	IC50	0.9284	4	4

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
spironolactone	Homo sapiens (human)	EC50	20.0000	1	1
norethindrone	Homo sapiens (human)	EC50	0.0022	1	1
norethindrone	Homo sapiens (human)	Kd	0.0004	1	1
medroxyprogesterone acetate	Homo sapiens (human)	EC50	0.6252	16	16
dihydrotestosterone	Homo sapiens (human)	EC50	8.2000	1	1
levonorgestrel	Homo sapiens (human)	EC50	0.0010	2	2
promegestone	Homo sapiens (human)	Kd	0.0004	1	1
mifepristone	Homo sapiens (human)	EC50	5.0002	2	2
ulipristal acetate	Homo sapiens (human)	EC50	0.1000	1	1
mometasone furoate	Homo sapiens (human)	Kd	0.0001	1	1
eplerenone	Homo sapiens (human)	EC50	20.0000	1	1
tanaproget	Homo sapiens (human)	EC50	0.0001	1	1
onapristone	Homo sapiens (human)	EC50	3.3346	3	3
pregna-4,17-diene-3,16-dione	Homo sapiens (human)	EC50	1.9000	1	1
asoprisnil	Homo sapiens (human)	EC50	0.1000	1	1
norgestomet	Homo sapiens (human)	EC50	0.0045	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
prednisolone	Homo sapiens (human)	Activity	5.0000	1	1
mifepristone	Homo sapiens (human)	Activity	0.0013	1	1
mifepristone	Homo sapiens (human)	Kif	0.0118	1	1

Enables

This protein enables 15 target(s):

Target	Category	Definition
RNA polymerase II cis-regulatory region sequence-specific DNA binding	molecular function	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]
DNA-binding transcription factor activity, RNA polymerase II-specific	molecular function	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
transcription coactivator binding	molecular function	Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. [GOC:krc]
DNA-binding transcription activator activity, RNA polymerase II-specific	molecular function	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]
DNA binding	molecular function	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
nuclear steroid receptor activity	molecular function	Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. [GOC:signaling, PMID:14708019]
G protein-coupled receptor activity	molecular function	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
steroid binding	molecular function	Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
ATPase binding	molecular function	Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. [GOC:ai]
estrogen response element binding	molecular function	Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. [GOC:ecd, PMID:15036253, PMID:17975005]
nuclear receptor activity	molecular function	A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
mitochondrial outer membrane	cellular component	The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
chromatin	cellular component	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]

Involved In

This protein is involved in 18 target(s):

Target	Category	Definition
ovulation from ovarian follicle	biological process	The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus. [GOC:mtg_sensu, https://www.ncbi.nlm.nih.gov/books/NBK279054/]
glandular epithelial cell maturation	biological process	The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. [GOC:dph]
regulation of DNA-templated transcription	biological process	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
cell-cell signaling	biological process	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah]
positive regulation of gene expression	biological process	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
negative regulation of gene expression	biological process	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
paracrine signaling	biological process	The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other. [GOC:mtg_signaling_feb11, ISBN:3527303782]
negative regulation of phosphorylation	biological process	Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. [GOC:jl]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
lung alveolus development	biological process	The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. [GOC:mtg_lung, PMID:9751757]
regulation of epithelial cell proliferation	biological process	Any process that modulates the frequency, rate or extent of epithelial cell proliferation. [GOC:ai]
progesterone receptor signaling pathway	biological process	The series of molecular signals initiated by progesterone binding to its receptor in the cytoplasm. [GOC:ai, GOC:mah, PMID:14744870]
maintenance of protein location in nucleus	biological process	Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. [GOC:ai]
tertiary branching involved in mammary gland duct morphogenesis	biological process	The branching process in which the mammary gland ducts form tertiary branches off of the secondary branches as part of diestrus and pregnancy. [GOC:dph, PMID:18614704]
regulation of transcription by RNA polymerase II	biological process	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
intracellular steroid hormone receptor signaling pathway	biological process	The series of molecular signals initiated by a steroid binding to an intracellular steroid hormone receptor. [GOC:mah, GOC:signaling]