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Carbonic anhydrase 14
A carbonic anhydrase 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9ULX7]
Synonyms
EC 4.2.1.1;
Carbonate dehydratase XIV;
Carbonic anhydrase XIV;
CA-XIV
Research
Bioassay Publications (88)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (2.27) | 18.7374 |
| 1990's | 2 (2.27) | 18.2507 |
| 2000's | 30 (34.09) | 29.6817 |
| 2010's | 50 (56.82) | 24.3611 |
| 2020's | 4 (4.55) | 2.80 |
Compounds (135)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| protocatechuic acid | Homo sapiens (human) | Ki | 0.6900 | 1 | 1 |
| 4-hydroxybenzoic acid | Homo sapiens (human) | Ki | 253.8162 | 3 | 16 |
| cadaverine | Homo sapiens (human) | Ki | 0.5000 | 1 | 1 |
| catechol | Homo sapiens (human) | Ki | 407.0643 | 3 | 14 |
| coumarin | Homo sapiens (human) | Ki | 100.0240 | 2 | 2 |
| salicylic acid | Homo sapiens (human) | Ki | 164.7214 | 2 | 14 |
| gallic acid | Homo sapiens (human) | Ki | 7.0300 | 1 | 1 |
| 4-aminophenol | Homo sapiens (human) | Ki | 479.5857 | 2 | 14 |
| hydroquinone | Homo sapiens (human) | Ki | 119.3921 | 2 | 14 |
| phenol | Homo sapiens (human) | Ki | 154.9625 | 5 | 16 |
| spermidine | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| spermine | Homo sapiens (human) | Ki | 0.8600 | 1 | 1 |
| catechin | Homo sapiens (human) | Ki | 11.5500 | 1 | 1 |
| beta-resorcylic acid | Homo sapiens (human) | Ki | 70.0000 | 1 | 1 |
| acetaminophen | Homo sapiens (human) | Ki | 148.1615 | 2 | 13 |
| acetazolamide | Homo sapiens (human) | IC50 | 0.1830 | 4 | 4 |
| acetazolamide | Homo sapiens (human) | Ki | 6.4966 | 49 | 93 |
| bumetanide | Homo sapiens (human) | Ki | 18.3242 | 1 | 12 |
| celecoxib | Homo sapiens (human) | Ki | 0.6890 | 2 | 2 |
| chlorthalidone | Homo sapiens (human) | Ki | 1.8850 | 2 | 14 |
| coumaphos | Homo sapiens (human) | Ki | 4.1400 | 1 | 1 |
| dichlorphenamide | Homo sapiens (human) | Ki | 26.2747 | 12 | 35 |
| ethoxzolamide | Homo sapiens (human) | Ki | 7.7156 | 14 | 26 |
| furosemide | Homo sapiens (human) | Ki | 14.5469 | 2 | 14 |
| 2,5-dihydroxybenzoic acid | Homo sapiens (human) | Ki | 67.0000 | 1 | 1 |
| hydrochlorothiazide | Homo sapiens (human) | Ki | 18.6042 | 1 | 12 |
| hydroflumethiazide | Homo sapiens (human) | Ki | 20.3203 | 1 | 12 |
| indapamide | Homo sapiens (human) | Ki | 19.4509 | 2 | 14 |
| mafenide | Homo sapiens (human) | Ki | 3.2000 | 2 | 2 |
| methazolamide | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| methazolamide | Homo sapiens (human) | Ki | 8.9986 | 11 | 23 |
| metolazone | Homo sapiens (human) | Ki | 22.0639 | 1 | 12 |
| resorcinol | Homo sapiens (human) | Ki | 278.4786 | 2 | 14 |
| resveratrol | Homo sapiens (human) | Ki | 1.9500 | 1 | 1 |
| saccharin | Homo sapiens (human) | Ki | 0.7730 | 1 | 1 |
| imatinib | Homo sapiens (human) | Ki | 0.4680 | 1 | 1 |
| sulfanilamide | Homo sapiens (human) | Ki | 5.4000 | 4 | 4 |
| sulthiame | Homo sapiens (human) | Ki | 52.8233 | 1 | 12 |
| trichlormethiazide | Homo sapiens (human) | Ki | 44.0148 | 2 | 26 |
| trientine | Homo sapiens (human) | Ki | 12.1000 | 1 | 1 |
| zonisamide | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| zonisamide | Homo sapiens (human) | Ki | 126.0486 | 6 | 18 |
| sulfamic acid | Homo sapiens (human) | Ki | 1,090.0000 | 1 | 1 |
| carbostyril | Homo sapiens (human) | Ki | 0.0360 | 2 | 2 |
| quinethazone | Homo sapiens (human) | Ki | 18.1300 | 1 | 2 |
| veratrole | Homo sapiens (human) | Ki | 6.8300 | 1 | 1 |
| veratric acid | Homo sapiens (human) | Ki | 0.7400 | 1 | 1 |
| benzenearsonic acid | Homo sapiens (human) | Ki | 84.0000 | 1 | 1 |
| benzenesulfonamide | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| alpha-resorcylic acid | Homo sapiens (human) | Ki | 0.6500 | 1 | 1 |
| methylparaben | Homo sapiens (human) | Ki | 4.1000 | 1 | 1 |
| diethylenetriamine | Homo sapiens (human) | Ki | 10.1000 | 1 | 1 |
| ethyl-p-hydroxybenzoate | Homo sapiens (human) | Ki | 7.7000 | 1 | 1 |
| carzenide | Homo sapiens (human) | Ki | 0.7800 | 1 | 1 |
| 1,4-dimethoxybenzene | Homo sapiens (human) | Ki | 6.7900 | 1 | 1 |
| gamma-resorcylic acid | Homo sapiens (human) | Ki | 6.5000 | 1 | 1 |
| syringic acid | Homo sapiens (human) | Ki | 9.1400 | 1 | 1 |
| herniarin | Homo sapiens (human) | Ki | 9.0000 | 1 | 1 |
| coumarin-3-carboxylic acid | Homo sapiens (human) | Ki | 8.2000 | 1 | 1 |
| 3-aminophenol | Homo sapiens (human) | Ki | 7.2000 | 1 | 1 |
| 4-cyanophenol | Homo sapiens (human) | Ki | 204.5649 | 2 | 14 |
| n-(1-naphthyl)ethylenediamine | Homo sapiens (human) | Ki | 0.5900 | 1 | 1 |
| 2,6-dimethoxybenzoic acid | Homo sapiens (human) | Ki | 0.5500 | 1 | 1 |
| 1,6-diaminohexane | Homo sapiens (human) | Ki | 0.6400 | 1 | 1 |
| benzolamide | Homo sapiens (human) | Ki | 28.0325 | 2 | 5 |
| 7-ethoxycoumarin | Homo sapiens (human) | Ki | 8.9000 | 1 | 1 |
| dobutamine | Homo sapiens (human) | Ki | 12.0200 | 1 | 1 |
| foscarnet sodium | Homo sapiens (human) | Ki | 3,600.0000 | 1 | 1 |
| succinylsulfanilamide | Homo sapiens (human) | Ki | 0.0061 | 1 | 1 |
| 4-chlorobenzenesulfonamide | Homo sapiens (human) | Ki | 0.0003 | 1 | 1 |
| benzeneboronic acid | Homo sapiens (human) | Ki | 71.0000 | 2 | 2 |
| 4-amino-6-chloro-1,3-benzenedisulfonamide | Homo sapiens (human) | Ki | 0.5700 | 1 | 1 |
| 1,2,4-trimethoxybenzene | Homo sapiens (human) | Ki | 0.6300 | 1 | 1 |
| zoledronic acid | Homo sapiens (human) | IC50 | 0.0920 | 2 | 2 |
| brinzolamide | Homo sapiens (human) | Ki | 0.0240 | 6 | 6 |
| 2,4-disulfamyl-5-trifluoromethylaniline | Homo sapiens (human) | Ki | 0.6800 | 1 | 1 |
| methanesulfonamide | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 2-aminobenzenesulfonamide | Homo sapiens (human) | Ki | 6.5000 | 1 | 1 |
| methyl gentisate | Homo sapiens (human) | Ki | 0.8000 | 1 | 1 |
| ethyl protocatechuate | Homo sapiens (human) | Ki | 0.8600 | 1 | 1 |
| 3,7-diazanonane-1,9-diamine | Homo sapiens (human) | Ki | 36.0000 | 1 | 1 |
| sulfamide | Homo sapiens (human) | Ki | 750.0000 | 2 | 2 |
| 5-amino-1,3,4-thiadiazole-2-sulfonamide | Homo sapiens (human) | Ki | 0.2800 | 2 | 2 |
| valdecoxib | Homo sapiens (human) | Ki | 0.1070 | 1 | 1 |
| 1-naphthylacetylspermine | Homo sapiens (human) | Ki | 1.0300 | 1 | 1 |
| 4-(2-aminoethyl)benzenesulfonamide | Homo sapiens (human) | Ki | 2.9000 | 2 | 2 |
| n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide | Homo sapiens (human) | Ki | 0.1040 | 2 | 3 |
| lacosamide | Homo sapiens (human) | Ki | 0.4730 | 1 | 1 |
| methyl 3,4-dihydroxybenzoate | Homo sapiens (human) | Ki | 0.8900 | 1 | 1 |
| bortezomib | Homo sapiens (human) | Ki | 3.2800 | 1 | 1 |
| resveratrol | Homo sapiens (human) | Ki | 0.8300 | 1 | 1 |
| rwj 37947 | Homo sapiens (human) | Ki | 0.0360 | 1 | 1 |
| ferulic acid | Homo sapiens (human) | Ki | 9.4300 | 2 | 2 |
| hydroxyphenethylferulate | Homo sapiens (human) | Ki | 0.7200 | 1 | 1 |
| 2-hydroxycinnamic acid | Homo sapiens (human) | Ki | 1,000.0000 | 1 | 1 |
| trans-4-coumaric acid | Homo sapiens (human) | Ki | 6.6800 | 2 | 2 |
| s 1033 | Homo sapiens (human) | Ki | 0.2230 | 1 | 1 |
| ethyl coumarate | Homo sapiens (human) | Ki | 0.8000 | 1 | 1 |
| caffeic acid | Homo sapiens (human) | Ki | 8.7100 | 2 | 2 |
| ethyl 2,4-dihydroxybenzoate | Homo sapiens (human) | Ki | 0.7400 | 1 | 1 |
| 7-methoxy-2-oxo-1-benzopyran-3-carboxylic acid ethyl ester | Homo sapiens (human) | Ki | 6.1000 | 1 | 1 |
| N1-[4-(aminosulfonyl)phenyl]-2,2-dimethylpropanamide | Homo sapiens (human) | Ki | 0.7300 | 1 | 1 |
| quercetin | Homo sapiens (human) | Ki | 5.4100 | 1 | 1 |
| ellagic acid | Homo sapiens (human) | Ki | 8.9100 | 1 | 1 |
| dorzolamide | Homo sapiens (human) | Ki | 43.6256 | 8 | 19 |
| topiramate | Homo sapiens (human) | Ki | 23.8591 | 14 | 34 |
| irosustat | Homo sapiens (human) | Ki | 54.4817 | 2 | 13 |
| methyl-p-coumarate | Homo sapiens (human) | Ki | 0.8300 | 1 | 1 |
| 3-cyano-7-hydroxycoumarin | Homo sapiens (human) | Ki | 48.2209 | 1 | 11 |
| famotidine | Homo sapiens (human) | Ki | 0.6772 | 1 | 1 |
| 6-hydroxybenzothiazide-2-sulfonamide | Homo sapiens (human) | Ki | 0.0480 | 1 | 1 |
| dodoneine | Homo sapiens (human) | Ki | 9.3400 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.Journal of medicinal chemistry, , Jan-14, Volume: 53, Issue:1, 2010
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 17, Issue:3, 2007
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.Journal of medicinal chemistry, , 02-11, Volume: 64, Issue:3, 2021
Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
[no title available]ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
Famotidine, an Antiulcer Agent, Strongly Inhibits ACS medicinal chemistry letters, , Oct-11, Volume: 9, Issue:10, 2018
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-15, Volume: 24, Issue:2, 2016
Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action.Bioorganic & medicinal chemistry, , Feb-15, Volume: 24, Issue:4, 2016
PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas.Journal of medicinal chemistry, , 05-26, Volume: 59, Issue:10, 2016
An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C.Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases.Journal of medicinal chemistry, , Sep-24, Volume: 58, Issue:18, 2015
Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.Journal of medicinal chemistry, , Nov-12, Volume: 58, Issue:21, 2015
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Dec-15, Volume: 22, Issue:24, 2014
Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.Journal of medicinal chemistry, , Nov-26, Volume: 57, Issue:22, 2014
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.European journal of medicinal chemistry, , Volume: 71, 2014
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 24, Issue:8, 2014
A prodrug approach toward cancer-related carbonic anhydrase inhibition.Journal of medicinal chemistry, , Dec-12, Volume: 56, Issue:23, 2013
Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Synthesis and carbonic anhydrase inhibitory properties of sulfamides structurally related to dopamine.Bioorganic & medicinal chemistry, , Jun-01, Volume: 21, Issue:11, 2013
Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Apr-26, Volume: 55, Issue:8, 2012
Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , May-15, Volume: 19, Issue:10, 2011
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.Journal of medicinal chemistry, , Jun-09, Volume: 54, Issue:11, 2011
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.Journal of medicinal chemistry, , Mar-25, Volume: 53, Issue:6, 2010
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 19, Issue:20, 2009
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 18, Issue:14, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.European journal of medicinal chemistry, , Volume: 43, Issue:12, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 17, Issue:4, 2007
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.Bioorganic & medicinal chemistry letters, , May-15, Volume: 17, Issue:10, 2007
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Acetazolamide-like carbonic anhydrase inhibitors with topical ocular hypotensive activity.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
N-Substituted sulfonamide carbonic anhydrase inhibitors with topical effects on intraocular pressure.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies.Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:4, 2014
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , May-15, Volume: 19, Issue:10, 2011
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 17, Issue:4, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.European journal of medicinal chemistry, , Volume: 71, 2014
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , May-15, Volume: 19, Issue:10, 2011
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 17, Issue:4, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 17, Issue:4, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Substituted thieno[2,3-b]thiophenes and related congeners: Synthesis, β-glucuronidase inhibition activity, crystal structure, and POM analyses.Bioorganic & medicinal chemistry, , Dec-01, Volume: 22, Issue:23, 2014
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Apr-26, Volume: 55, Issue:8, 2012
Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry, , Dec-01, Volume: 19, Issue:23, 2011
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.Journal of medicinal chemistry, , Jun-09, Volume: 54, Issue:11, 2011
Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.Journal of medicinal chemistry, , Mar-25, Volume: 53, Issue:6, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?Chemical biology & drug design, , Volume: 74, Issue:3, 2009
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 17, Issue:17, 2007
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 24, Issue:8, 2014
Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 17, Issue:4, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Inhibition of mammalian carbonic anhydrase isoforms I-XIV with a series of phenolic acid esters.Bioorganic & medicinal chemistry, , Nov-15, Volume: 23, Issue:22, 2015
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Inhibition of mammalian carbonic anhydrase isoforms I-XIV with a series of phenolic acid esters.Bioorganic & medicinal chemistry, , Nov-15, Volume: 23, Issue:22, 2015
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Inhibition of mammalian carbonic anhydrase isoforms I-XIV with a series of phenolic acid esters.Bioorganic & medicinal chemistry, , Nov-15, Volume: 23, Issue:22, 2015
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 17, Issue:4, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Apr-26, Volume: 55, Issue:8, 2012
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.Journal of medicinal chemistry, , Jun-09, Volume: 54, Issue:11, 2011
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.Journal of medicinal chemistry, , Mar-25, Volume: 53, Issue:6, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 17, Issue:10, 2009
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.European journal of medicinal chemistry, , Volume: 43, Issue:12, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.Bioorganic & medicinal chemistry letters, , May-15, Volume: 17, Issue:10, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| carbonate dehydratase activity | molecular function | Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. [EC:4.2.1.1] |
Located In
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 1 target(s):
| Target | Category | Definition |
|---|
| one-carbon metabolic process | biological process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. [GOC:hjd, GOC:mah, GOC:pde] |