Proteins > 7-dehydrocholesterol reductase
Page last updated: 2024-08-07 13:47:45

7-dehydrocholesterol reductase

A 7-dehydrocholesterol reductase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBM7]

Synonyms

7-DHC reductase;
EC 1.3.1.21;
Delta7-sterol reductase;
Sterol Delta(7)-reductase;
Sterol reductase SR-2

Research

Bioassay Publications (3)

TimeframeStudies on this Protein(%)All Drugs %
pre-19901 (33.33)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Compounds (2)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
chrysamine gHomo sapiens (human)Ki0.000411
tamoxifenHomo sapiens (human)IC500.012011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
tamoxifenHomo sapiens (human)Kd0.001011

Enables

This protein enables 3 target(s):

TargetCategoryDefinition
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
7-dehydrocholesterol reductase activitymolecular functionCatalysis of the reaction: cholesterol + NADP+ = 7-dehydrocholesterol + H+ + NADPH. [RHEA:23984]
NADP bindingmolecular functionBinding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. [GOC:ai]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
nuclear outer membranecellular componentThe outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. [ISBN:0198547684]
endoplasmic reticulumcellular componentThe irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
endoplasmic reticulum membranecellular componentThe lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
endoplasmic reticulum membranecellular componentThe lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

Involved In

This protein is involved in 4 target(s):

TargetCategoryDefinition
cholesterol biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:ai]
cholesterol biosynthetic process via desmosterolbiological processThe chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate desmosterol. [GOC:mah, MetaCyc:PWY66-4]
cholesterol biosynthetic process via lathosterolbiological processThe chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol. [GOC:mah, MetaCyc:PWY66-341]
brassinosteroid biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. [ISBN:0192801023]