Proteins > Retinoic acid receptor RXR-alpha
Page last updated: 2024-08-07 17:01:07
Retinoic acid receptor RXR-alpha
A retinoic acid receptor RXR-alpha that is encoded in the genome of rat. [OMA:Q05343, PRO:DNx]
Synonyms
Nuclear receptor subfamily 2 group B member 1;
Retinoid X receptor alpha
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| lg 100268 | Rattus norvegicus (Norway rat) | Ki | 0.0180 | 1 | 1 |
| lg 1506 | Rattus norvegicus (Norway rat) | IC50 | 0.0080 | 1 | 1 |
| lg 1506 | Rattus norvegicus (Norway rat) | Ki | 0.0030 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| lg 100268 | Rattus norvegicus (Norway rat) | EC50 | 0.0110 | 1 | 1 |
| bexarotene | Rattus norvegicus (Norway rat) | EC50 | 0.0400 | 1 | 1 |
| alitretinoin | Rattus norvegicus (Norway rat) | EC50 | 0.1150 | 2 | 2 |
| uab 30 | Rattus norvegicus (Norway rat) | EC50 | 0.6100 | 2 | 2 |
Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids.Journal of medicinal chemistry, , Sep-11, Volume: 46, Issue:19, 2003
Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity.Journal of medicinal chemistry, , Jun-26, Volume: 57, Issue:12, 2014
Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids.Journal of medicinal chemistry, , Sep-11, Volume: 46, Issue:19, 2003
Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity.Journal of medicinal chemistry, , Jun-26, Volume: 57, Issue:12, 2014
Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014