Proteins > Sigma non-opioid intracellular receptor 1
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Sigma non-opioid intracellular receptor 1
A sigma non-opioid intracellular receptor 1 that is encoded in the genome of guinea pig. [OMA:Q60492, PRO:DNx]
Synonyms
Sigma 1-type opioid receptor;
Sigma1-receptor;
Sigma1R;
Sterol isomerase-like protein
Research
Bioassay Publications (88)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (17.05) | 29.6817 |
| 2010's | 54 (61.36) | 24.3611 |
| 2020's | 19 (21.59) | 2.80 |
Compounds (71)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| phenethylamine | Cavia porcellus (domestic guinea pig) | Ki | 10.0000 | 1 | 1 |
| 1,3-dipropyl-8-cyclopentylxanthine | Cavia porcellus (domestic guinea pig) | Ki | 0.2600 | 1 | 1 |
| acetazolamide | Cavia porcellus (domestic guinea pig) | Ki | 0.2500 | 1 | 1 |
| 5-aminoisoquinolinone | Cavia porcellus (domestic guinea pig) | IC50 | 0.2400 | 1 | 1 |
| theophylline | Cavia porcellus (domestic guinea pig) | Ki | 7.9000 | 1 | 1 |
| amphetamine | Cavia porcellus (domestic guinea pig) | Ki | 10.0000 | 1 | 1 |
| valproic acid | Cavia porcellus (domestic guinea pig) | Ki | 10.0000 | 1 | 1 |
| donepezil | Cavia porcellus (domestic guinea pig) | Ki | 0.0146 | 2 | 2 |
| fentanyl | Cavia porcellus (domestic guinea pig) | IC50 | 4.9730 | 1 | 1 |
| fentanyl | Cavia porcellus (domestic guinea pig) | Ki | 2.4743 | 1 | 1 |
| fluoxetine | Cavia porcellus (domestic guinea pig) | Ki | 0.0022 | 1 | 1 |
| haloperidol | Cavia porcellus (domestic guinea pig) | Ki | 0.0048 | 36 | 36 |
| ifenprodil | Cavia porcellus (domestic guinea pig) | Ki | 0.1051 | 12 | 12 |
| modafinil | Cavia porcellus (domestic guinea pig) | Ki | 2.0000 | 1 | 1 |
| pentazocine | Cavia porcellus (domestic guinea pig) | Ki | 0.0054 | 1 | 1 |
| vorinostat | Cavia porcellus (domestic guinea pig) | IC50 | 0.0700 | 1 | 1 |
| n,n-dimethyltryptamine | Cavia porcellus (domestic guinea pig) | Ki | 15.0000 | 1 | 1 |
| 1,3-ditolylguanidine | Cavia porcellus (domestic guinea pig) | Ki | 0.0789 | 24 | 24 |
| indopan | Cavia porcellus (domestic guinea pig) | Ki | 10.0000 | 1 | 1 |
| tranylcypromine | Cavia porcellus (domestic guinea pig) | Ki | 1.8000 | 1 | 1 |
| sufentanil | Cavia porcellus (domestic guinea pig) | IC50 | 2.0770 | 1 | 1 |
| staurosporine | Cavia porcellus (domestic guinea pig) | IC50 | 0.0067 | 2 | 2 |
| alfentanil | Cavia porcellus (domestic guinea pig) | IC50 | 10.0000 | 1 | 1 |
| rimcazole | Cavia porcellus (domestic guinea pig) | IC50 | 1.0235 | 2 | 2 |
| rimcazole | Cavia porcellus (domestic guinea pig) | Ki | 0.9080 | 1 | 1 |
| simvastatin | Cavia porcellus (domestic guinea pig) | IC50 | 0.0490 | 1 | 1 |
| eliprodil | Cavia porcellus (domestic guinea pig) | Ki | 0.0670 | 3 | 3 |
| remifentanil | Cavia porcellus (domestic guinea pig) | IC50 | 10.0000 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine | Cavia porcellus (domestic guinea pig) | Ki | 0.0320 | 1 | 1 |
| 4-fluorofentanyl | Cavia porcellus (domestic guinea pig) | IC50 | 0.4953 | 1 | 1 |
| 2,5-dimethoxyamphetamine | Cavia porcellus (domestic guinea pig) | Ki | 4.7200 | 1 | 1 |
| epigallocatechin gallate | Cavia porcellus (domestic guinea pig) | IC50 | 10.0000 | 1 | 1 |
| dioxadrol | Cavia porcellus (domestic guinea pig) | Ki | 0.0350 | 1 | 1 |
| 2-(2,5-dimethoxyphenyl)ethanamine | Cavia porcellus (domestic guinea pig) | Ki | 2.8200 | 1 | 1 |
| bexarotene | Cavia porcellus (domestic guinea pig) | Ki | 0.0210 | 1 | 2 |
| fenpropimorph | Cavia porcellus (domestic guinea pig) | Ki | 0.0000 | 3 | 3 |
| epicatechin gallate | Cavia porcellus (domestic guinea pig) | IC50 | 10.0000 | 1 | 1 |
| marimastat | Cavia porcellus (domestic guinea pig) | IC50 | 0.0031 | 1 | 1 |
| 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol | Cavia porcellus (domestic guinea pig) | Ki | 0.0028 | 3 | 3 |
| 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide | Cavia porcellus (domestic guinea pig) | Ki | 0.0012 | 1 | 1 |
| l 687384 | Cavia porcellus (domestic guinea pig) | Ki | 0.0020 | 1 | 1 |
| ly 293558 | Cavia porcellus (domestic guinea pig) | Ki | 4.2000 | 1 | 1 |
| n-(n-benzylpiperidin-4-yl)-4-iodobenzamide | Cavia porcellus (domestic guinea pig) | Ki | 0.0017 | 1 | 1 |
| l 741626 | Cavia porcellus (domestic guinea pig) | Ki | 0.1040 | 1 | 1 |
| 3-methoxyamphetamine | Cavia porcellus (domestic guinea pig) | Ki | 10.0000 | 1 | 1 |
| besonprodil | Cavia porcellus (domestic guinea pig) | Ki | 0.0300 | 1 | 1 |
| n-desmethylmethoxyphenamine | Cavia porcellus (domestic guinea pig) | Ki | 10.0000 | 1 | 1 |
| (-)-gallocatechin gallate | Cavia porcellus (domestic guinea pig) | IC50 | 10.0000 | 1 | 1 |
| pentazocine | Cavia porcellus (domestic guinea pig) | Ki | 0.0052 | 9 | 9 |
| bd 1063 | Cavia porcellus (domestic guinea pig) | Ki | 0.0140 | 1 | 1 |
| vesamicol | Cavia porcellus (domestic guinea pig) | Ki | 0.0738 | 1 | 1 |
| 2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-1-benzopyran-4-one | Cavia porcellus (domestic guinea pig) | IC50 | 0.7400 | 1 | 1 |
| naloxone | Cavia porcellus (domestic guinea pig) | Ki | 0.1030 | 1 | 1 |
| dextromethorphan | Cavia porcellus (domestic guinea pig) | IC50 | 0.1236 | 2 | 2 |
| dextromethorphan | Cavia porcellus (domestic guinea pig) | Ki | 0.0365 | 2 | 2 |
| gw843682x | Cavia porcellus (domestic guinea pig) | IC50 | 0.0020 | 1 | 1 |
| lu 28-179 | Cavia porcellus (domestic guinea pig) | Ki | 0.0170 | 2 | 2 |
| sa 4503 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0170 | 1 | 1 |
| sa 4503 | Cavia porcellus (domestic guinea pig) | Ki | 0.0043 | 1 | 1 |
| bibr 1532 | Cavia porcellus (domestic guinea pig) | IC50 | 7.5850 | 2 | 2 |
| LSM-1328 | Cavia porcellus (domestic guinea pig) | Ki | 5.0050 | 1 | 2 |
| 77-lh-28-1 | Cavia porcellus (domestic guinea pig) | Ki | 0.0072 | 1 | 1 |
| n-cyclopropyl adenosine-5'-carboxamide | Cavia porcellus (domestic guinea pig) | Ki | 4.1200 | 1 | 1 |
| PB28 | Cavia porcellus (domestic guinea pig) | Ki | 0.0004 | 4 | 4 |
| lapatinib ditosylate | Cavia porcellus (domestic guinea pig) | IC50 | 0.0163 | 1 | 1 |
| e-52862 | Cavia porcellus (domestic guinea pig) | Ki | 0.0067 | 3 | 3 |
| wms 1410 | Cavia porcellus (domestic guinea pig) | Ki | 0.1940 | 2 | 2 |
| n,n-diallyl-5-methoxytryptamine | Cavia porcellus (domestic guinea pig) | Ki | 0.3991 | 1 | 2 |
| dolutegravir | Cavia porcellus (domestic guinea pig) | Ki | 0.0975 | 2 | 2 |
| olanzapine | Cavia porcellus (domestic guinea pig) | Ki | 0.0090 | 1 | 1 |
Drugs with Activation Measurements
1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation, and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives.Journal of medicinal chemistry, , Dec-15, Volume: 48, Issue:25, 2005
1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation, and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives.Journal of medicinal chemistry, , Dec-15, Volume: 48, Issue:25, 2005
[no title available]Journal of medicinal chemistry, , 09-22, Volume: 65, Issue:18, 2022
Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil.European journal of medicinal chemistry, , Jul-05, Volume: 237, 2022
[no title available]European journal of medicinal chemistry, , Feb-15, Volume: 230, 2022
[no title available]Journal of medicinal chemistry, , 09-22, Volume: 65, Issue:18, 2022
Synthesis of 8-aminomorphans with high KOR affinity.European journal of medicinal chemistry, , Feb-15, Volume: 230, 2022
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.European journal of medicinal chemistry, , Feb-15, Volume: 230, 2022
Haloperidol Metabolite II Valproate Ester (Journal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021
[no title available]European journal of medicinal chemistry, , Jul-05, Volume: 219, 2021
Novel σEuropean journal of medicinal chemistry, , Jan-15, Volume: 210, 2021
Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.Journal of medicinal chemistry, , 01-14, Volume: 64, Issue:1, 2021
[no title available]European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
[no title available]European journal of medicinal chemistry, , Mar-15, Volume: 190, 2020
[no title available]Bioorganic & medicinal chemistry, , 12-01, Volume: 27, Issue:23, 2019
[no title available]European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
2-Methyltetrahydro-3-benzazepin-1-ols - The missing link in SAR of GluN2B selective NMDA receptor antagonists.Bioorganic & medicinal chemistry, , 01-15, Volume: 26, Issue:2, 2018
[no title available]European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
[no title available]Bioorganic & medicinal chemistry, , 04-15, Volume: 25, Issue:8, 2017
Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors.European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.Bioorganic & medicinal chemistry letters, , 12-01, Volume: 26, Issue:23, 2016
New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation.Bioorganic & medicinal chemistry, , 07-15, Volume: 24, Issue:14, 2016
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells.Journal of medicinal chemistry, , 11-10, Volume: 59, Issue:21, 2016
Improving selectivity preserving affinity: new piperidine-4-carboxamide derivatives as effective sigma-1-ligands.European journal of medicinal chemistry, , Jan-27, Volume: 90, 2015
Synthesis and biological evaluation of a novel sigma-1 receptor antagonist based on 3,4-dihydro-2(1H)-quinolinone scaffold as a potential analgesic.European journal of medicinal chemistry, , May-22, Volume: 79, 2014
From NMDA receptor antagonists to discovery of selective σ₂ receptor ligands.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
Identification, pharmacological evaluation and binding mode analysis of novel chromene and chromane based σ1 receptor ligands.European journal of medicinal chemistry, , Aug-18, Volume: 83, 2014
New combination of pharmacophoric elements of potent σ₁ ligands: design, synthesis and σ receptor affinity of aminoethyl substituted tetrahydrobenzothiophenes.European journal of medicinal chemistry, , Volume: 69, 2013
Thiophene bioisosteres of spirocyclic σ receptor ligands: relationships between substitution pattern and σ receptor affinity.Journal of medicinal chemistry, , Jun-14, Volume: 55, Issue:11, 2012
Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with high σ₁ receptor affinity.Journal of medicinal chemistry, , Oct-13, Volume: 54, Issue:19, 2011
Synthesis and pharmacological evaluation of fluorine-containing D₃ dopamine receptor ligands.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Design, synthesis and pharmacological evaluation of spirocyclic σ(1) receptor ligands with exocyclic amino moiety (increased distance 1).Bioorganic & medicinal chemistry, , May-15, Volume: 19, Issue:10, 2011
Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Synthesis of sigma receptor ligands with unsymmetrical spiro connection of the piperidine moiety.European journal of medicinal chemistry, , Volume: 44, Issue:11, 2009
Relationships between the structure of 6-substituted 6,8-diazabicyclo[3.2.2]nonan-2-ones and their sigma receptor affinity and cytotoxic activity.Bioorganic & medicinal chemistry, , Feb-15, Volume: 17, Issue:4, 2009
Synthesis and structure-activity relationships of N-(3-phenylpropyl)-N'-benzylpiperazines: Potent ligands for sigma1 and sigma2 receptors.Bioorganic & medicinal chemistry, , Jan-15, Volume: 16, Issue:2, 2008
[no title available]Journal of medicinal chemistry, , 09-22, Volume: 65, Issue:18, 2022
[no title available]European journal of medicinal chemistry, , Mar-15, Volume: 190, 2020
[no title available]Bioorganic & medicinal chemistry, , 12-01, Volume: 27, Issue:23, 2019
Synthesis and receptor binding of thiophene bioisosteres of potent GluN2B ligands with a benzo[7]annulene-scaffold.MedChemComm, , Feb-01, Volume: 10, Issue:2, 2019
2-Methyltetrahydro-3-benzazepin-1-ols - The missing link in SAR of GluN2B selective NMDA receptor antagonists.Bioorganic & medicinal chemistry, , 01-15, Volume: 26, Issue:2, 2018
Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
[no title available]European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
Pyridine bioisosteres of potent GluN2B subunit containing NMDA receptor antagonists with benzo[7]annulene scaffold.European journal of medicinal chemistry, , Sep-05, Volume: 157, 2018
Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors.European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
Synthesis, GluN2B affinity and selectivity of benzo[7]annulen-7-amines.Bioorganic & medicinal chemistry, , Dec-01, Volume: 22, Issue:23, 2014
From NMDA receptor antagonists to discovery of selective σ₂ receptor ligands.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
[no title available]European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety.Journal of medicinal chemistry, , 11-08, Volume: 61, Issue:21, 2018
Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil.European journal of medicinal chemistry, , Jul-05, Volume: 237, 2022
[no title available]European journal of medicinal chemistry, , Feb-15, Volume: 230, 2022
[no title available]Journal of medicinal chemistry, , 09-22, Volume: 65, Issue:18, 2022
Synthesis and RSC medicinal chemistry, , Mar-04, Volume: 12, Issue:2, 2021
[no title available]European journal of medicinal chemistry, , Jul-05, Volume: 219, 2021
Novel σEuropean journal of medicinal chemistry, , Jan-15, Volume: 210, 2021
[no title available]Journal of medicinal chemistry, , 04-25, Volume: 62, Issue:8, 2019
[no title available]Bioorganic & medicinal chemistry, , 12-01, Volume: 27, Issue:23, 2019
[no title available]European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
2-Methyltetrahydro-3-benzazepin-1-ols - The missing link in SAR of GluN2B selective NMDA receptor antagonists.Bioorganic & medicinal chemistry, , 01-15, Volume: 26, Issue:2, 2018
Synthesis of 3-aza[4.4.3]propellanes with high σBioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
[no title available]European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
[no title available]Bioorganic & medicinal chemistry, , 04-15, Volume: 25, Issue:8, 2017
Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors.European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
Identification, pharmacological evaluation and binding mode analysis of novel chromene and chromane based σ1 receptor ligands.European journal of medicinal chemistry, , Aug-18, Volume: 83, 2014
New combination of pharmacophoric elements of potent σ₁ ligands: design, synthesis and σ receptor affinity of aminoethyl substituted tetrahydrobenzothiophenes.European journal of medicinal chemistry, , Volume: 69, 2013
Thiophene bioisosteres of spirocyclic σ receptor ligands: relationships between substitution pattern and σ receptor affinity.Journal of medicinal chemistry, , Jun-14, Volume: 55, Issue:11, 2012
Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with high σ₁ receptor affinity.Journal of medicinal chemistry, , Oct-13, Volume: 54, Issue:19, 2011
Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
Synthesis and NMDA receptor affinity of fluorinated dioxadrol analogues.Bioorganic & medicinal chemistry, , Jun-01, Volume: 18, Issue:11, 2010
Synthesis of sigma receptor ligands with unsymmetrical spiro connection of the piperidine moiety.European journal of medicinal chemistry, , Volume: 44, Issue:11, 2009
Relationships between the structure of 6-substituted 6,8-diazabicyclo[3.2.2]nonan-2-ones and their sigma receptor affinity and cytotoxic activity.Bioorganic & medicinal chemistry, , Feb-15, Volume: 17, Issue:4, 2009
Novel sigma receptor ligands: synthesis and biological profile.Journal of medicinal chemistry, , Mar-08, Volume: 50, Issue:5, 2007
Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents.European journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Synthesis and structure-activity relationships of N-(3-phenylpropyl)-N'-benzylpiperazines: Potent ligands for sigma1 and sigma2 receptors.Bioorganic & medicinal chemistry, , Jan-15, Volume: 16, Issue:2, 2008
Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil.European journal of medicinal chemistry, , Jul-05, Volume: 237, 2022
[no title available]European journal of medicinal chemistry, , Feb-15, Volume: 230, 2022
Synthesis, GluN2B affinity and selectivity of benzo[7]annulen-7-amines.Bioorganic & medicinal chemistry, , Dec-01, Volume: 22, Issue:23, 2014
Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Reevaluation of fenpropimorph as a σ receptor ligand: Structure-affinity relationship studies at human σBioorganic & medicinal chemistry letters, , 07-01, Volume: 27, Issue:13, 2017
Structure of the σ1 receptor and its ligand binding site.Journal of medicinal chemistry, , Dec-27, Volume: 56, Issue:24, 2013
Synthesis and characterization of N,N-dialkyl and N-alkyl-N-aralkyl fenpropimorph-derived compounds as high affinity ligands for sigma receptors.Bioorganic & medicinal chemistry, , Jun-15, Volume: 18, Issue:12, 2010
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.European journal of medicinal chemistry, , Feb-15, Volume: 230, 2022
Haloperidol Metabolite II Valproate Ester (Journal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells.Journal of medicinal chemistry, , 11-10, Volume: 59, Issue:21, 2016
Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil.European journal of medicinal chemistry, , Jul-05, Volume: 237, 2022
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σEuropean journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
[no title available]European journal of medicinal chemistry, , Feb-15, Volume: 230, 2022
Synthesis of 8-aminomorphans with high KOR affinity.European journal of medicinal chemistry, , Feb-15, Volume: 230, 2022
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.European journal of medicinal chemistry, , Feb-15, Volume: 230, 2022
Synthesis and RSC medicinal chemistry, , Mar-04, Volume: 12, Issue:2, 2021
[no title available]European journal of medicinal chemistry, , Jul-05, Volume: 219, 2021
Novel σEuropean journal of medicinal chemistry, , Jan-15, Volume: 210, 2021
Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.Journal of medicinal chemistry, , 01-14, Volume: 64, Issue:1, 2021
Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.Journal of medicinal chemistry, , 01-14, Volume: 64, Issue:1, 2021
Synthesis and structure-activity relationships of N-(3-phenylpropyl)-N'-benzylpiperazines: Potent ligands for sigma1 and sigma2 receptors.Bioorganic & medicinal chemistry, , Jan-15, Volume: 16, Issue:2, 2008
Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety.Journal of medicinal chemistry, , 11-08, Volume: 61, Issue:21, 2018
Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands.Journal of medicinal chemistry, , May-22, Volume: 57, Issue:10, 2014
Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.Journal of medicinal chemistry, , 12-24, Volume: 63, Issue:24, 2020
Synthesis and structure-activity relationships of N-(3-phenylpropyl)-N'-benzylpiperazines: Potent ligands for sigma1 and sigma2 receptors.Bioorganic & medicinal chemistry, , Jan-15, Volume: 16, Issue:2, 2008
Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety.Journal of medicinal chemistry, , 11-08, Volume: 61, Issue:21, 2018
Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells.Journal of medicinal chemistry, , Aug-25, Volume: 54, Issue:16, 2011
Arylamides hybrids of two high-affinity σ2 receptor ligands as tools for the development of PET radiotracers.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).Journal of medicinal chemistry, , Dec-10, Volume: 52, Issue:23, 2009
[no title available]European journal of medicinal chemistry, , Nov-05, Volume: 241, 2022
Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.Journal of medicinal chemistry, , 01-14, Volume: 64, Issue:1, 2021
Synthesis and biological evaluation of a novel sigma-1 receptor antagonist based on 3,4-dihydro-2(1H)-quinolinone scaffold as a potential analgesic.European journal of medicinal chemistry, , May-22, Volume: 79, 2014
2-Methyltetrahydro-3-benzazepin-1-ols - The missing link in SAR of GluN2B selective NMDA receptor antagonists.Bioorganic & medicinal chemistry, , 01-15, Volume: 26, Issue:2, 2018
Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.European journal of medicinal chemistry, , Feb-15, Volume: 230, 2022
Improving selectivity preserving affinity: new piperidine-4-carboxamide derivatives as effective sigma-1-ligands.European journal of medicinal chemistry, , Jan-27, Volume: 90, 2015