simvastatin has been researched along with Necrosis in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 4 (13.79) | 18.2507 |
| 2000's | 13 (44.83) | 29.6817 |
| 2010's | 10 (34.48) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Arnaboldi, F; Bitto, N; Colombo, M; Denti, L; Dondossola, D; Gagliano, N; La Mura, V; Latini, R; Liguori, E; Peyvandi, F; Procacci, P; Ristagno, G; Salerno, F; Sartori, P; Tripodi, A | 1 |
| Alupei, MC; Banciu, M; Cristian, FB; Licarete, E | 1 |
| Alves-Júnior, MJ; Anhê, GF; de Moraes Schenka, NG; De Souza, PC; de Souza, VB; Hyslop, S; Jampietro, J; Rennó, AL; Rocha, RM; Schenka, AA; Soares, FA; Vassallo, J | 1 |
| Almasan, A; Babcook, MA; Daneshgari, F; Fujioka, H; Gupta, S; Nanavaty, RR; Shukla, S; Sramkoski, RM | 1 |
| Gandhi, HP; Patel, SS; Rathod, SP; Trivedi, JI; Variya, BC | 1 |
| Ding, HJ; Ong, SG | 1 |
| Bläuer, M; Murtola, TJ; Pennanen, P; Savinainen, K; Syvälä, H; Tammela, TLJ; Ylikomi, T | 1 |
| Buerke, M; Buerke, U; Carter, JM; Grandel, U; Grimminger, F; Mueller-Werdan, U; Russ, M; Schlitt, A; Schmidt, H; Seeger, W; Sibelius, U; Werdan, K | 1 |
| Lóopez-Marure, R; Massó, FA; Montaño, LF; Páez, A; Rodríguez, E; Sánchez, CA; Varela, E; Zapata, E | 1 |
| Balduini, W; Buonocore, G; Carloni, S | 1 |
| de Carvalho, M; Evangelista, T; Ferro, J; Pereira, P | 1 |
| Hong, MK; Kang, DH; Kim, JJ; Kim, YH; Lee, CW; Lee, SW; Park, DW; Park, SJ; Park, SW; Song, JK | 1 |
| McDaniel, MC; Samady, H | 1 |
| Bababeygy, SR; Hou, LC; Polevaya, NV; Prugpichailers, T; Steinman, L; Sun, A; Tse, V; Veeravagu, A; Xiong, A; Youssef, S | 1 |
| Garcia-Garcia, HM; Okamura, T; Serruys, PW; Shin, ES | 1 |
| Constantin-Teodosiu, D; Davies, WJ; Glaves, PD; Greenhaff, PL; Mallinson, JE; Martin, EA; Sidaway, JE; Westwood, FR | 1 |
| Darshan, J; Gadola, SD; Gallagher, PJ; Green, B; Shaw, E | 1 |
| Costa, RA; de Souza-Pinto, NC; Fernandes, MP; Vercesi, AE | 1 |
| Drucker, L; Gronich, N; Lishner, M; Radnay, J; Shapiro, H; Yarkoni, S | 1 |
| Iwano, C; Matsuyama, K; Matzno, S; Nishikata, M; Yasuda, N | 1 |
| Cakmak, A; Demirpençe, E; Deniz Dinçer, U; Köksoy, A; Köksoy, C; Okcu-Heper, A; Oziş, E; Yazgan, U | 1 |
| Andrews, B; Ramdass, MJ; Singh, G | 1 |
| Boltan, DD; Bouffard, JP; Khetan, A; Lachar, W; Roberts, WC | 1 |
| Assie, N; Bruniquel, F; Degryse, AD; Delhon, A; Oms, P; van Haverbeke, G | 1 |
| Fujiyama, J; Higuchi, I; Kuriyama, M; Nakagawa, H; Nakahara, K; Osame, M; Sonoda, Y; Yoshidome, H | 1 |
| Farvid, AR; Gibson, MF; Hoffmeyer, MR; Jones, SP; Lefer, AM; Lefer, DJ; Scalia, R; Sharp, BR | 1 |
| Eydelloth, RS; Germershausen, JI; Grossman, SJ; MacDonald, JS; Schwartz, MS; Smith, PF; Stubbs, RJ | 1 |
| Desager, JP; Harvengt, C; Horsmans, Y | 1 |
| Alberts, AW; Bokelman, DL; Gerson, RJ; Kornbrust, DJ; MacDonald, JS; Majka, JA; Stubbs, RJ | 1 |
1 review(s) available for simvastatin and Necrosis
| Article | Year |
|---|---|
Animal safety and toxicology of simvastatin and related hydroxy-methylglutaryl-coenzyme A reductase inhibitors.
Topics: Animals; Cataract; Dogs; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Male; Necrosis; Rabbits; Rats; Simvastatin; Species Specificity; Stomach; Testis | 1989 |
1 trial(s) available for simvastatin and Necrosis
| Article | Year |
|---|---|
Effects of statin treatments on coronary plaques assessed by volumetric virtual histology intravascular ultrasound analysis.
Topics: Aged; Calcinosis; Coronary Angiography; Coronary Artery Disease; Female; Fibrosis; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Necrosis; Predictive Value of Tests; Pyrimidines; Rosuvastatin Calcium; Severity of Illness Index; Simvastatin; Sulfonamides; Time Factors; Treatment Outcome; Ultrasonography, Interventional; User-Computer Interface | 2009 |
27 other study(ies) available for simvastatin and Necrosis
| Article | Year |
|---|---|
Simvastatin Prevents Liver Microthrombosis and Sepsis Induced Coagulopathy in a Rat Model of Endotoxemia.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Endotoxemia; Fibrin; Hemostatics; Lipopolysaccharides; Liver Diseases; Male; Necrosis; Rats; Rats, Wistar; Sepsis; Simvastatin; Thrombosis; von Willebrand Factor | 2022 |
Cytotoxicity of lipophilic statins depends on their combined actions on HIF-1α expression and redox status in B16.F10 melanoma cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit; Melanoma, Experimental; Mice; Necrosis; Oxidation-Reduction; Oxidative Stress; Pravastatin; Simvastatin | 2014 |
Decreased expression of stem cell markers by simvastatin in 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, CD; Biomarkers; Biomarkers, Tumor; Carcinogens; Disease Progression; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Mammary Neoplasms, Experimental; Necrosis; Neoplastic Stem Cells; Rats; Rats, Sprague-Dawley; Simvastatin | 2015 |
Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Autophagy; Cell Line, Tumor; Chloroquine; Drug Combinations; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; HMGB1 Protein; Humans; Imidazoles; Indoles; Male; Metformin; Microtubule-Associated Proteins; Necrosis; Prostate; Prostatic Neoplasms, Castration-Resistant; Receptor-Interacting Protein Serine-Threonine Kinases; RNA, Small Interfering; Sequestosome-1 Protein; Signal Transduction; Simvastatin | 2014 |
Comparative evaluation of HMG CoA reductase inhibitors in experimentally-induced myocardial necrosis: Biochemical, morphological and histological studies.
Topics: Adenosine Triphosphatases; Animals; Atorvastatin; Blood Glucose; Cardiotonic Agents; Catalase; Cholesterol; Fatty Acids, Monounsaturated; Fluvastatin; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Isoproterenol; Male; Myocardial Infarction; Myocardium; Necrosis; Pravastatin; Rats, Wistar; Rosuvastatin Calcium; Simvastatin; Superoxide Dismutase; Triglycerides | 2015 |
Patient with statin-associated immune-mediated necrotizing myopathy presenting with subcutaneous edema, persistent bulbar weakness and absent anti-HMGCR.
Topics: Aged; Autoantibodies; Azathioprine; Biopsy; Bulbar Palsy, Progressive; Edema; Glucocorticoids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Male; Muscle Weakness; Muscle, Skeletal; Muscular Diseases; Necrosis; Prednisolone; Recovery of Function; Simvastatin; Treatment Outcome | 2017 |
The effects of metformin and simvastatin on the growth of LNCaP and RWPE-1 prostate epithelial cell lines.
Topics: Adenosine Triphosphate; Apoptosis; Autophagy; Cell Count; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Interactions; Epithelial Cells; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Male; Metformin; Necrosis; Prostate; Simvastatin | 2016 |
Apoptosis contributes to septic cardiomyopathy and is improved by simvastatin therapy.
Topics: Animals; Apoptosis; Cardiomyopathies; Exotoxins; Heart; Hemodynamics; In Situ Nick-End Labeling; In Vitro Techniques; Myocardium; Necrosis; Rats; Sepsis; Simvastatin; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2008 |
Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Atorvastatin; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Proliferation; DNA Replication; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Membrane Potential, Mitochondrial; Necrosis; Oxidative Stress; Pyrroles; Reactive Oxygen Species; Simvastatin | 2008 |
Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury.
Topics: Adenine; Analysis of Variance; Androstadienes; Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Cell Count; Cerebral Cortex; Hippocampus; Hypoxia-Ischemia, Brain; Immunohistochemistry; In Situ Nick-End Labeling; Necrosis; Neurons; Rats; Rats, Sprague-Dawley; Simvastatin; Sirolimus; Wortmannin | 2008 |
A case of asymptomatic cytoplasmic body myopathy revealed by sinvastatin.
Topics: Aged; Biopsy; Creatine Kinase; Cytoplasm; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inclusion Bodies; Male; Muscle Weakness; Muscle, Skeletal; Muscular Diseases; Necrosis; Pain; Pyrimidines; Rhabdomyolysis; Rosuvastatin Calcium; Simvastatin; Sulfonamides | 2009 |
Can statins alter coronary plaque composition assessed by radiofrequency backscatter intravascular ultrasound?
Topics: Calcinosis; Coronary Artery Disease; Fatty Acids, Monounsaturated; Fibrosis; Fluorobenzenes; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Necrosis; Observer Variation; Predictive Value of Tests; Pyrimidines; Radiography; Rosuvastatin Calcium; Severity of Illness Index; Simvastatin; Sulfonamides; Time Factors; Treatment Outcome; Ultrasonography, Interventional; User-Computer Interface | 2009 |
HMG-CoA reductase inhibition causes increased necrosis and apoptosis in an in vivo mouse glioblastoma multiforme model.
Topics: Acyl Coenzyme A; Animals; Apoptosis; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelium, Vascular; Glioblastoma; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoenzyme Techniques; Mice; Mice, Inbred C57BL; Necrosis; Neoplasms, Experimental; Neovascularization, Physiologic; Simvastatin | 2009 |
Effect of statins on coronary bifurcation atherosclerosis: an intravascular ultrasound virtual histology study.
Topics: Aged; Chi-Square Distribution; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Disease Progression; Female; Fibrosis; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Logistic Models; Male; Middle Aged; Necrosis; Odds Ratio; Plaque, Atherosclerotic; Predictive Value of Tests; Pyrimidines; Retrospective Studies; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Time Factors; Treatment Outcome; Ultrasonography, Interventional; Vascular Calcification | 2012 |
Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.
Topics: Acetylcarnitine; Animals; Body Weight; Carbohydrate Metabolism; Cathepsin L; Cytoprotection; Dichloroacetic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Enzyme Activation; Enzyme Activators; Female; Forkhead Transcription Factors; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle Proteins; Muscle, Skeletal; Muscular Diseases; Necrosis; Oxidation-Reduction; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Rats; Rats, Wistar; RNA, Messenger; Simvastatin; SKP Cullin F-Box Protein Ligases; Time Factors | 2012 |
Intestinal ischaemia and mesenteric necrosis in a heavy smoker.
Topics: Abdominal Pain; Aspirin; Diarrhea; Humans; Jejunal Diseases; Male; Mesenteric Arteries; Middle Aged; Necrosis; Simvastatin; Smoking Cessation; Thromboangiitis Obliterans; Treatment Outcome; Weight Loss | 2013 |
Protective effects of l-carnitine and piracetam against mitochondrial permeability transition and PC3 cell necrosis induced by simvastatin.
Topics: Carnitine; Cell Line, Tumor; Cyclosporine; Drug Synergism; Humans; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Necrosis; Piracetam; Simvastatin; Superoxides | 2013 |
Simvastatin induces death of multiple myeloma cell lines.
Topics: Anticholesteremic Agents; Antineoplastic Agents; Apoptosis; Calcium; Cell Cycle; Cell Death; Cell Line, Tumor; Humans; Interleukin-6; Multiple Myeloma; Necrosis; Phosphorylation; Simvastatin; Tyrosine | 2004 |
Evaluation of apoptosis and necrosis induced by statins using fluorescence-enhanced flow cytometry.
Topics: Apoptosis; Atorvastatin; Avidin; Biotin; Cell Line; Cell Separation; Cells, Cultured; Drug Industry; Drug Screening Assays, Antitumor; Fatty Acids, Monounsaturated; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Leukemia; Microscopy, Fluorescence; Necrosis; Pharmaceutical Preparations; Pravastatin; Propidium; Pyridines; Pyrroles; Simvastatin; Time Factors | 2005 |
Simvastatin pretreatment reduces the severity of limb ischemia in an experimental diabetes model.
Topics: Animals; Diabetes Mellitus, Experimental; Edema; Glutathione; Hindlimb; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemia; Male; Malondialdehyde; Muscle, Skeletal; Necrosis; Peroxidase; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Severity of Illness Index; Simvastatin; Time Factors; Tourniquets | 2007 |
Simvastatin-induced bilateral leg compartment syndrome and myonecrosis associated with hypothyroidism.
Topics: Anticholesteremic Agents; Compartment Syndromes; Humans; Hypercholesterolemia; Hypothyroidism; Male; Middle Aged; Muscle, Skeletal; Necrosis; Simvastatin; Thyroxine | 2007 |
Fatal and widespread skeletal myopathy confirmed morphologically years after initiation of simvastatin therapy.
Topics: Calcinosis; Deglutition Disorders; Dysarthria; Dyspnea; Fatal Outcome; Fibrosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Male; Middle Aged; Muscle Fibers, Skeletal; Muscle Weakness; Muscular Diseases; Necrosis; Simvastatin | 2007 |
Biochemical changes and morphological alterations of liver and kidney in hamsters after administration of the HMG-coenzyme A reductase inhibitor, simvastatin: prevention and reversibility by mevalonate.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Cricetinae; Dietary Fats; Eating; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Liver; Lovastatin; Male; Mevalonic Acid; Necrosis; Simvastatin | 1995 |
Myopathy induced by HMG-CoA reductase inhibitors in rabbits: a pathological, electrophysiological, and biochemical study.
Topics: Animals; Cholesterol; Creatine Kinase; Electromyography; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Microscopy, Electron; Mitochondria, Muscle; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Diseases; Myotonia; Necrosis; Phospholipids; Pravastatin; Rabbits; Simvastatin; Tissue Distribution; Ubiquinone | 1998 |
HMG-CoA reductase inhibition protects the diabetic myocardium from ischemia-reperfusion injury.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemotaxis, Leukocyte; Diabetes Mellitus, Type 2; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Models, Biological; Myocardial Ischemia; Myocardial Reperfusion Injury; Necrosis; Neutrophils; Nitric Acid; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; RNA, Messenger; Simvastatin | 2001 |
Myopathy associated with HMG-CoA reductase inhibitors (HMGRIs) and cyclosporin A: evaluation in a rat model.
Topics: Animals; Anticholesteremic Agents; Cyclosporine; Drug Synergism; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Muscles; Muscular Diseases; Necrosis; Pravastatin; Rats; Rats, Inbred Strains; Simvastatin; Structure-Activity Relationship | 1992 |
Biochemical changes and morphological alterations of the liver in guinea-pigs after administration of simvastatin (HMG CoA reductase-inhibitor).
Topics: Aminopyrine N-Demethylase; Animals; Bile Ducts; Body Weight; Cholesterol; Colestipol; Cytochrome P-450 Enzyme System; Eating; Guinea Pigs; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Male; Necrosis; Simvastatin | 1990 |