nimesulide has been researched along with Necrosis in 8 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The diagnosis of toxic hepatitis due to nimesulide was supported by the time-course of drug usage, sex, age, absence of other causes of liver disease, a compatible liver biopsy and the improvement after drug withdrawal." | 5.31 | [Bleeding gastric ulcers and acute hepatitis: 2 simultaneous adverse reactions due to nimesulide in a case]. ( Meneses, M; Reyes, H; Tejos, S; Torrejón, N, 2000) |
| "Nimesulide-induced liver injury can present with hepatocellular necrosis or with pure cholestasis." | 3.70 | Nimesulide-induced acute hepatitis: evidence from six cases. ( Büscher, H; De Bondt, J; Desmet, V; Laporta, T; Peeters, P; Roskams, T; Staessen, D; Van Steenbergen, W, 1998) |
| "Nimesulide can cause toxicity to mitochondria in vitro, although it is unlikely that the high concentrations required are therapeutically relevant." | 2.41 | Nimesulide and hepatic adverse effects: roles of reactive metabolites and host factors. ( Boelsterli, UA, 2002) |
| "The diagnosis of toxic hepatitis due to nimesulide was supported by the time-course of drug usage, sex, age, absence of other causes of liver disease, a compatible liver biopsy and the improvement after drug withdrawal." | 1.31 | [Bleeding gastric ulcers and acute hepatitis: 2 simultaneous adverse reactions due to nimesulide in a case]. ( Meneses, M; Reyes, H; Tejos, S; Torrejón, N, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Farooq, M | 1 |
| Khan, AA | 1 |
| Boelsterli, UA | 1 |
| Saeed, SA | 2 |
| Ahmed, S | 2 |
| Seed, MP | 1 |
| Freemantle, CN | 1 |
| Alam, CA | 1 |
| Colville-Nash, PR | 1 |
| Brown, JR | 1 |
| Papworth, JL | 1 |
| Somerville, KW | 1 |
| Willoughby, DA | 1 |
| Van Steenbergen, W | 1 |
| Peeters, P | 1 |
| De Bondt, J | 1 |
| Staessen, D | 1 |
| Büscher, H | 1 |
| Laporta, T | 1 |
| Roskams, T | 1 |
| Desmet, V | 1 |
| Schattner, A | 1 |
| Sokolovskaya, N | 1 |
| Cohen, J | 1 |
| Tejos, S | 1 |
| Torrejón, N | 1 |
| Reyes, H | 1 |
| Meneses, M | 1 |
1 review available for nimesulide and Necrosis
| Article | Year |
|---|---|
Nimesulide and hepatic adverse effects: roles of reactive metabolites and host factors.
Topics: Biotransformation; Cyclooxygenase Inhibitors; Humans; Incidence; Liver; Mitochondria, Liver; Necrosi | 2002 |
7 other studies available for nimesulide and Necrosis
| Article | Year |
|---|---|
Evaluation of histo-toxicity of nimesulide in Black Kites (Milvus migrans): a pharmacodynamic study.
Topics: Adult; Animals; Birds; Body Weight; Humans; Male; Necrosis; Raptors; Uric Acid | 2023 |
Anti-ischemic effects of nimesulide, a cyclooxygenase-2 inhibitor on the ischemic model of rabbit induced by isoproterenol.
Topics: Adrenergic beta-Agonists; Animals; Coronary Circulation; Creatine Kinase; Cyclooxygenase 2 Inhibitor | 2006 |
New aspects of cyclooxygenase-2 inhibition in myocardial infarction and ischaemia.
Topics: Adrenergic beta-Agonists; Animals; Cardiotonic Agents; Creatine Kinase; Cyclooxygenase 2; Cyclooxyge | 2005 |
Apoptosis induction and inhibition of colon-26 tumour growth and angiogenesis: findings on COX-1 and COX-2 inhibitors in vitro & in vivo and topical diclofenac in hyaluronan.
Topics: Administration, Topical; Animals; Apoptosis; Aspirin; Cell Division; Cell Survival; Colonic Neoplasm | 1997 |
Nimesulide-induced acute hepatitis: evidence from six cases.
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver | 1998 |
Fatal hepatitis and renal failure during treatment with nimesulide.
Topics: Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Bacteremia; Chemical and Drug In | 2000 |
[Bleeding gastric ulcers and acute hepatitis: 2 simultaneous adverse reactions due to nimesulide in a case].
Topics: Acute Disease; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury | 2000 |