Proteins > Bifunctional dihydrofolate reductase-thymidylate synthase
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Bifunctional dihydrofolate reductase-thymidylate synthase
[no definition available]
Synonyms
DHFR-TS
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (2)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| trimethoprim | Plasmodium berghei ANKA | IC50 | 0.1200 | 5 | 5 |
| diaveridine | Plasmodium berghei ANKA | IC50 | 0.2100 | 1 | 1 |
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes.Journal of medicinal chemistry, , Volume: 30, Issue:2, 1987
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 8. The 3,4,5-triethyl isostere of trimethoprim. A study of specificity.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 2. C-Alkylation of pyrimidines with Mannich bases and application to the synthesis of trimethoprim and analogues.Journal of medicinal chemistry, , Volume: 23, Issue:4, 1980
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 4. 6-Substituted trimethoprim derivatives from phenolic Mannich intermediates. Application to the synthesis of trimethoprim and 3,5-dialkylbenzyl analogues.Journal of medicinal chemistry, , Volume: 23, Issue:5, 1980