Proteins > Xanthine dehydrogenase/oxidase
Page last updated: 2024-08-07 16:56:05
Xanthine dehydrogenase/oxidase
A xanthine dehydrogenase/oxidase that is encoded in the genome of cow. [PMID:8708081, PRO:HJD]
Synonyms
Research
Bioassay Publications (54)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (3.70) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (9.26) | 29.6817 |
| 2010's | 40 (74.07) | 24.3611 |
| 2020's | 7 (12.96) | 2.80 |
Compounds (55)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| protocatechuic acid | Bos taurus (cattle) | IC50 | 5.8000 | 1 | 1 |
| salicylic acid | Bos taurus (cattle) | Ki | 100,000.0000 | 1 | 1 |
| beta-naphthoflavone | Bos taurus (cattle) | IC50 | 20.0000 | 1 | 1 |
| vanillic acid | Bos taurus (cattle) | IC50 | 8.5000 | 1 | 1 |
| alpha-naphthoflavone | Bos taurus (cattle) | IC50 | 20.0000 | 1 | 1 |
| 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose | Bos taurus (cattle) | IC50 | 3.2000 | 1 | 1 |
| 2,4,6-trihydroxybenzoic acid | Bos taurus (cattle) | IC50 | 6.5000 | 1 | 1 |
| geniposide | Bos taurus (cattle) | IC50 | 161.4000 | 1 | 1 |
| liquiritigenin | Bos taurus (cattle) | IC50 | 11.3000 | 1 | 1 |
| aromadedrin | Bos taurus (cattle) | IC50 | 93.8000 | 1 | 1 |
| febuxostat | Bos taurus (cattle) | IC50 | 0.0166 | 16 | 16 |
| febuxostat | Bos taurus (cattle) | Ki | 0.0005 | 2 | 2 |
| 1-acetyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazole | Bos taurus (cattle) | IC50 | 61.4000 | 1 | 1 |
| geniposidic acid | Bos taurus (cattle) | IC50 | 62.1600 | 1 | 1 |
| ferulic acid | Bos taurus (cattle) | IC50 | 8.2000 | 1 | 1 |
| y-700 | Bos taurus (cattle) | IC50 | 0.0078 | 4 | 4 |
| trans-4-coumaric acid | Bos taurus (cattle) | IC50 | 6.8000 | 1 | 1 |
| 2'-hydroxychalcone | Bos taurus (cattle) | IC50 | 71.3000 | 1 | 1 |
| 2,2'-dihydroxychalcone | Bos taurus (cattle) | IC50 | 87.4000 | 1 | 1 |
| isoliquiritigenin | Bos taurus (cattle) | IC50 | 47.3000 | 1 | 1 |
| 1-benzyl-2-phenylbenzimidazole | Bos taurus (cattle) | IC50 | 9.7000 | 1 | 1 |
| 6-(4-methoxyphenyl)pyrimidine-2,4-diamine | Bos taurus (cattle) | IC50 | 100.0000 | 1 | 1 |
| 2',3-dihydroxychalcone | Bos taurus (cattle) | IC50 | 91.8000 | 1 | 1 |
| quercetin | Bos taurus (cattle) | IC50 | 31.9000 | 1 | 1 |
| quercetin | Bos taurus (cattle) | Ki | 1.2000 | 1 | 1 |
| acacetin | Bos taurus (cattle) | IC50 | 14.1000 | 1 | 1 |
| apigenin | Bos taurus (cattle) | IC50 | 6.8900 | 2 | 2 |
| luteolin | Bos taurus (cattle) | IC50 | 10.2000 | 1 | 1 |
| luteolin | Bos taurus (cattle) | Ki | 1.9000 | 1 | 1 |
| luteolin-7-glucoside | Bos taurus (cattle) | IC50 | 75.9000 | 1 | 1 |
| chrysoeriol | Bos taurus (cattle) | IC50 | 14.0000 | 1 | 1 |
| quercetin 3-o-methyl ether | Bos taurus (cattle) | IC50 | 31.6000 | 1 | 1 |
| 3-methylkaempferol | Bos taurus (cattle) | IC50 | 0.0040 | 1 | 1 |
| genistein | Bos taurus (cattle) | IC50 | 1.7300 | 1 | 1 |
| butein | Bos taurus (cattle) | IC50 | 1.3000 | 1 | 1 |
| okanin | Bos taurus (cattle) | IC50 | 1.2000 | 1 | 1 |
| sulfuretin | Bos taurus (cattle) | IC50 | 3.1000 | 1 | 1 |
| amentoflavone | Bos taurus (cattle) | IC50 | 35.3000 | 1 | 1 |
| baicalein | Bos taurus (cattle) | IC50 | 37.4000 | 2 | 2 |
| chrysin | Bos taurus (cattle) | IC50 | 1.2600 | 1 | 1 |
| norathyriol | Bos taurus (cattle) | IC50 | 21.7300 | 1 | 1 |
| robinetin | Bos taurus (cattle) | IC50 | 4.3000 | 1 | 1 |
| santin | Bos taurus (cattle) | IC50 | 0.2200 | 1 | 1 |
| scutellarein | Bos taurus (cattle) | IC50 | 12.6000 | 1 | 1 |
| wogonin | Bos taurus (cattle) | IC50 | 176.1000 | 1 | 1 |
| 4-hydroxychalcone | Bos taurus (cattle) | IC50 | 224.5000 | 2 | 2 |
| topiroxostat | Bos taurus (cattle) | IC50 | 0.8919 | 6 | 6 |
| topiroxostat | Bos taurus (cattle) | Ki | 0.0057 | 1 | 1 |
| 4',5,7-trihydroxy-3,6-dimethoxyflavone | Bos taurus (cattle) | IC50 | 0.0400 | 2 | 2 |
| 2',4'-dihydroxychalcone | Bos taurus (cattle) | IC50 | 107.0000 | 1 | 1 |
| 4,4'-dihydroxychalcone | Bos taurus (cattle) | IC50 | 117.0000 | 1 | 1 |
| 2,4,2'-trihydroxychalcone | Bos taurus (cattle) | IC50 | 56.8000 | 1 | 1 |
| 3-nitrobenzaldehyde isonicotinoylhydrazone | Bos taurus (cattle) | IC50 | 173.5600 | 1 | 1 |
| sesone | Bos taurus (cattle) | Ki | 47.5000 | 2 | 2 |
| allopurinol | Bos taurus (cattle) | IC50 | 13.7520 | 42 | 42 |
| allopurinol | Bos taurus (cattle) | Ki | 1.8000 | 2 | 2 |
| 2-amino-4-hydroxy-6-formylpteridine | Bos taurus (cattle) | Ki | 0.0018 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| allopurinol | Bos taurus (cattle) | Kd | 0.0005 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| xanthine | Bos taurus (cattle) | Km | 21.4000 | 1 | 1 |
| 5-bromocytosine | Bos taurus (cattle) | Km | 32.5000 | 2 | 2 |
| silybin | Bos taurus (cattle) | Km | 55.4500 | 4 | 4 |
| quercetin | Bos taurus (cattle) | Km | 65.3000 | 4 | 4 |
| luteolin | Bos taurus (cattle) | Km | 32.3500 | 4 | 4 |
| allopurinol | Bos taurus (cattle) | Km | 58.3750 | 4 | 4 |
Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site.Bioorganic & medicinal chemistry, , 05-15, Volume: 38, 2021
Synthesis and bioevaluation of 1-phenylimidazole-4-carboxylic acid derivatives as novel xanthine oxidoreductase inhibitors.European journal of medicinal chemistry, , Jan-15, Volume: 186, 2020
Switching a Xanthine Oxidase Inhibitor to a Dual-Target Antagonist of P2YJournal of medicinal chemistry, , 12-24, Volume: 63, Issue:24, 2020
Design, synthesis and bioevaluation of 3-oxo-6-aryl-2,3-dihydropyridazine-4-carbohydrazide derivatives as novel xanthine oxidase inhibitors.Bioorganic & medicinal chemistry, , 05-01, Volume: 27, Issue:9, 2019
Benzoflavone derivatives as potent antihyperuricemic agents.MedChemComm, , Jan-01, Volume: 10, Issue:1, 2019
Targeting the subpocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Design, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Discovery of 2-phenylthiazole-4-carboxylic acid, a novel and potent scaffold as xanthine oxidase inhibitors.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 29, Issue:4, 2019
Synthesis and bioevaluation of 1-phenyl-pyrazole-4-carboxylic acid derivatives as potent xanthine oxidoreductase inhibitors.European journal of medicinal chemistry, , Nov-10, Volume: 140, 2017
Carboxylated aurone derivatives as potent inhibitors of xanthine oxidase.Bioorganic & medicinal chemistry, , 07-15, Volume: 25, Issue:14, 2017
Development of 2-(Substituted Benzylamino)-4-Methyl-1, 3-Thiazole-5-Carboxylic Acid Derivatives as Xanthine Oxidase Inhibitors and Free Radical Scavengers.Chemical biology & drug design, , Volume: 87, Issue:4, 2016
Synthesis and evaluation of 1-hydroxy/methoxy-4-methyl-2-phenyl-1H-imidazole-5-carboxylic acid derivatives as non-purine xanthine oxidase inhibitors.European journal of medicinal chemistry, , Oct-20, Volume: 103, 2015
Synthesis and bioevaluation of 2-phenyl-4-methyl-1,3-selenazole-5-carboxylic acids as potent xanthine oxidase inhibitors.European journal of medicinal chemistry, , Oct-06, Volume: 85, 2014
Microwave assisted synthesis of naphthopyrans catalysed by silica supported fluoroboric acid as a new class of non purine xanthine oxidase inhibitors.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
X-ray crystal structure of a xanthine oxidase complex with the flavonoid inhibitor quercetin.Journal of natural products, , Jul-25, Volume: 77, Issue:7, 2014
Lead optimization of isocytosine-derived xanthine oxidase inhibitors.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 23, Issue:3, 2013
Synthesis of some 5-phenylisoxazole-3-carboxylic acid derivatives as potent xanthine oxidase inhibitors.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
Synthesis and bioevaluation of 1-phenyl-pyrazole-4-carboxylic acid derivatives as potent xanthine oxidoreductase inhibitors.European journal of medicinal chemistry, , Nov-10, Volume: 140, 2017
Synthesis and evaluation of 1-phenyl-1H-1,2,3-triazole-4-carboxylic acid derivatives as xanthine oxidase inhibitors.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 27, Issue:16, 2017
Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-09, Volume: 11, Issue:7, 2001
Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin.Journal of natural products, , Volume: 72, Issue:4, 2009
Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Synthesis, screening and docking of fused pyrano[3,2-d]pyrimidine derivatives as xanthine oxidase inhibitor.European journal of medicinal chemistry, , May-05, Volume: 131, 2017
Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin.Journal of natural products, , Volume: 72, Issue:4, 2009
Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 27, Issue:15, 2017
Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengers.Bioorganic & medicinal chemistry, , Feb-15, Volume: 24, Issue:4, 2016
Design, synthesis and biological evaluation of N-(3-(1H-tetrazol-1-yl)phenyl)isonicotinamide derivatives as novel xanthine oxidase inhibitors.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Discovery of 2-phenylthiazole-4-carboxylic acid, a novel and potent scaffold as xanthine oxidase inhibitors.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 29, Issue:4, 2019
Design, synthesis and biological evaluation of 1-hydroxy-2-phenyl-4-pyridyl-1H-imidazole derivatives as xanthine oxidase inhibitors.European journal of medicinal chemistry, , Feb-25, Volume: 146, 2018
Synthesis and bioevaluation of 1-phenyl-pyrazole-4-carboxylic acid derivatives as potent xanthine oxidoreductase inhibitors.European journal of medicinal chemistry, , Nov-10, Volume: 140, 2017
Design, synthesis and biological evaluation of N-(4-alkoxy-3-cyanophenyl)isonicotinamide/nicotinamide derivatives as novel xanthine oxidase inhibitors.European journal of medicinal chemistry, , Dec-01, Volume: 141, 2017
Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 - a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia [corrected].Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 19, Issue:21, 2009
Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 60, 2022
Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis.European journal of medicinal chemistry, , Jul-05, Volume: 237, 2022
Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site.Bioorganic & medicinal chemistry, , 05-15, Volume: 38, 2021
Arylsulfonyl histamine derivatives as powerful and selective α-glucosidase inhibitors.RSC medicinal chemistry, , Apr-01, Volume: 11, Issue:4, 2020
Design, synthesis and biological evaluation of 1-alkyl-5/6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.European journal of medicinal chemistry, , Mar-15, Volume: 190, 2020
Design, synthesis and bioevaluation of 3-oxo-6-aryl-2,3-dihydropyridazine-4-carbohydrazide derivatives as novel xanthine oxidase inhibitors.Bioorganic & medicinal chemistry, , 05-01, Volume: 27, Issue:9, 2019
Benzoflavone derivatives as potent antihyperuricemic agents.MedChemComm, , Jan-01, Volume: 10, Issue:1, 2019
Targeting the subpocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Design, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Propolis Components from Stingless Bees Collected on South Sulawesi, Indonesia, and Their Xanthine Oxidase Inhibitory Activity.Journal of natural products, , 02-22, Volume: 82, Issue:2, 2019
Design, synthesis and biological evaluation of novel xanthine oxidase inhibitors bearing a 2-arylbenzo[b]furan scaffold.European journal of medicinal chemistry, , May-10, Volume: 151, 2018
Synthesis, structure-activity relationships, and mechanistic studies of 5-arylazo-tropolone derivatives as novel xanthine oxidase (XO) inhibitors.Bioorganic & medicinal chemistry, , 01-15, Volume: 26, Issue:2, 2018
Xanthine oxidase inhibitory activity of natural and hemisynthetic flavonoids from Gardenia oudiepe (Rubiaceae) in vitro and molecular docking studies.European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Design, synthesis and biological evaluation of N-(4-alkoxy-3-cyanophenyl)isonicotinamide/nicotinamide derivatives as novel xanthine oxidase inhibitors.European journal of medicinal chemistry, , Dec-01, Volume: 141, 2017
Discovery and biological evaluation of some (1H-1,2,3-triazol-4-yl)methoxybenzaldehyde derivatives containing an anthraquinone moiety as potent xanthine oxidase inhibitors.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 27, Issue:4, 2017
Synthesis and bioevaluation of 1-phenyl-pyrazole-4-carboxylic acid derivatives as potent xanthine oxidoreductase inhibitors.European journal of medicinal chemistry, , Nov-10, Volume: 140, 2017
Synthesis and evaluation of 1-phenyl-1H-1,2,3-triazole-4-carboxylic acid derivatives as xanthine oxidase inhibitors.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 27, Issue:16, 2017
Xanthine oxidase inhibitory activity of nicotino/isonicotinohydrazides: A systematic approach from in vitro, in silico to in vivo studies.Bioorganic & medicinal chemistry, , 04-15, Volume: 25, Issue:8, 2017
Synthesis, screening and docking of fused pyrano[3,2-d]pyrimidine derivatives as xanthine oxidase inhibitor.European journal of medicinal chemistry, , May-05, Volume: 131, 2017
Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 27, Issue:15, 2017
Anti-gout nor-oleanane triterpenoids from the leaves of Stauntonia brachyanthera.Bioorganic & medicinal chemistry letters, , 06-15, Volume: 26, Issue:12, 2016
Synthesis and xanthine oxidase inhibitory activity of 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives.Bioorganic chemistry, , Volume: 57, 2014
Antioxidant, α-glucosidase and xanthine oxidase inhibitory activity of bioactive compounds from maize (Zea mays L.).Chemical biology & drug design, , Volume: 83, Issue:1, 2014
Design, synthesis and molecular modeling of aloe-emodin derivatives as potent xanthine oxidase inhibitors.European journal of medicinal chemistry, , Mar-21, Volume: 75, 2014
Microwave assisted synthesis of naphthopyrans catalysed by silica supported fluoroboric acid as a new class of non purine xanthine oxidase inhibitors.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
In vitro evaluation of selected benzimidazole derivatives as an antioxidant and xanthine oxidase inhibitors.Chemical biology & drug design, , Volume: 82, Issue:3, 2013
Lead optimization of isocytosine-derived xanthine oxidase inhibitors.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 23, Issue:3, 2013
Synthesis, biological evaluation, and molecular docking of N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl}-benzamide/amide derivatives as xanthine oxidase and tyrosinase inhibitors.Bioorganic & medicinal chemistry, , Sep-15, Volume: 20, Issue:18, 2012
Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits.Bioorganic & medicinal chemistry, , May-01, Volume: 20, Issue:9, 2012
Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives.Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
N-(1,3-Diaryl-3-oxopropyl)amides as a new template for xanthine oxidase inhibitors.Bioorganic & medicinal chemistry, , Sep-15, Volume: 19, Issue:18, 2011
A rational approach for the design and synthesis of 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles as a new class of potential non-purine xanthine oxidase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin.Journal of natural products, , Volume: 72, Issue:4, 2009
Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 - a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia [corrected].Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 19, Issue:21, 2009
Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-09, Volume: 11, Issue:7, 2001
2-pyridylimidazoles as inhibitors of xanthine oxidase.Journal of medicinal chemistry, , Volume: 20, Issue:9, 1977
Synthesis and enzymic activity of some novel xanthine oxidase inhibitors. 3-Substituted 5,7-dihydroxypyrazolo(1,5-alpha)pyrimidines.Journal of medicinal chemistry, , Volume: 19, Issue:2, 1976
Pentagalloylglucose, a xanthine oxidase inhibitor from a Paraguayan crude drug, "Molle-i" (Schinus terebinthifolius).Journal of natural products, , Volume: 52, Issue:1