A sodium channel protein type 9 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15858]
Neuroendocrine sodium channel;
hNE-Na;
Peripheral sodium channel 1;
PN1;
Sodium channel protein type IX subunit alpha;
Voltage-gated sodium channel subunit alpha Nav1.7
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 20 (83.33) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| phenytoin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| amiodarone | Homo sapiens (human) | IC50 | 4.8000 | 1 | 1 |
| amitriptyline | Homo sapiens (human) | IC50 | 9.3333 | 3 | 3 |
| carbamazepine | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |
| carbamazepine | Homo sapiens (human) | Ki | 32.7000 | 1 | 1 |
| chlorpromazine | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| cifenline | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| haloperidol | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| lidocaine | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| imipramine | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| lamotrigine | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| mexiletine | Homo sapiens (human) | IC50 | 11,290.0000 | 5 | 5 |
| mexiletine | Homo sapiens (human) | Ki | 13.0000 | 1 | 1 |
| nifedipine | Homo sapiens (human) | IC50 | 37.0000 | 1 | 1 |
| nitrendipine | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| tetracaine | Homo sapiens (human) | IC50 | 1.4693 | 6 | 6 |
| tetracaine | Homo sapiens (human) | Ki | 6.2500 | 2 | 2 |
| pimozide | Homo sapiens (human) | IC50 | 0.0540 | 1 | 1 |
| mexiletine hydrochloride | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| diltiazem | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| sertindole | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| mibefradil | Homo sapiens (human) | IC50 | 0.7400 | 2 | 2 |
| tedisamil | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| uk 68798 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| safinamide | Homo sapiens (human) | IC50 | 66.5000 | 2 | 2 |
| senicapoc | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| lacosamide | Homo sapiens (human) | IC50 | 0.1820 | 1 | 1 |
| ica-121431 | Homo sapiens (human) | IC50 | 7.6000 | 2 | 2 |
| tetrodotoxin | Homo sapiens (human) | IC50 | 0.0186 | 1 | 1 |
| 4-(4-fluorophenoxy)benzaldehyde semicarbazone | Homo sapiens (human) | Ki | 0.3600 | 1 | 1 |
| tetrodotoxin | Homo sapiens (human) | IC50 | 0.0203 | 3 | 2 |
| a 803467 | Homo sapiens (human) | IC50 | 16.2733 | 3 | 3 |
| decarbamylsaxitoxin | Homo sapiens (human) | IC50 | 0.1500 | 1 | 1 |
| n-dodecyl-l-lysine amide | Homo sapiens (human) | IC50 | 0.1778 | 1 | 1 |
| saxitoxin | Homo sapiens (human) | IC50 | 0.7020 | 2 | 2 |
| ajmaline | Homo sapiens (human) | IC50 | 8.2000 | 1 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated sodium channel activity | molecular function | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| axon | cellular component | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated sodium channel complex | cellular component | A sodium channel in a cell membrane whose opening is governed by the membrane potential. [ISBN:0198506732] |
This protein is involved in 11 target(s):
| Target | Category | Definition |
|---|---|---|
| sodium ion transport | biological process | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| inflammatory response | biological process | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] |
| circadian rhythm | biological process | Any biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:bf, GOC:go_curators] |
| response to toxic substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr] |
| post-embryonic development | biological process | The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. [GOC:go_curators] |
| sensory perception of pain | biological process | The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. [GOC:curators] |
| sodium ion transmembrane transport | biological process | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw] |
| behavioral response to pain | biological process | Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. [GOC:jid] |
| detection of temperature stimulus involved in sensory perception of pain | biological process | The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos] |
| detection of mechanical stimulus involved in sensory perception | biological process | The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception. [GOC:ai, GOC:dos] |
| cardiac muscle cell action potential involved in contraction | biological process | An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |