A dual specificity protein phosphatase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16690]
EC 3.1.3.16;
EC 3.1.3.48;
Dual specificity protein phosphatase hVH3
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| suramin | Homo sapiens (human) | Ki | 0.0250 | 1 | 1 |
| nsc-87877 | Homo sapiens (human) | IC50 | 1,700.0000 | 1 | 0 |
This protein enables 8 target(s):
| Target | Category | Definition |
|---|---|---|
| protein tyrosine phosphatase activity | molecular function | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| protein tyrosine/serine/threonine phosphatase activity | molecular function | Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [GOC:mah] |
| phosphatase activity | molecular function | Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions. [GOC:curators, GOC:pg] |
| myosin phosphatase activity | molecular function | Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. [EC:3.1.3.16] |
| MAP kinase tyrosine phosphatase activity | molecular function | Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate. [GOC:mah] |
| protein tyrosine/threonine phosphatase activity | molecular function | Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [GOC:mah] |
| MAP kinase tyrosine/serine/threonine phosphatase activity | molecular function | Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate. [GOC:mah, PMID:12184814] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| MAPK cascade | biological process | An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. [PMID:20811974, PMID:9561267] |
| protein dephosphorylation | biological process | The process of removing one or more phosphoric residues from a protein. [GOC:hb] |
| dephosphorylation | biological process | The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. [ISBN:0198506732] |
| peptidyl-tyrosine dephosphorylation | biological process | The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. [GOC:bf] |
| peptidyl-threonine dephosphorylation | biological process | The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine. [GOC:bf] |
| ERK1 and ERK2 cascade | biological process | A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development. [PMID:20811974, PMID:23125017, PMID:28903453] |
| endoderm formation | biological process | The formation of the endoderm during gastrulation. [GOC:go_curators] |
| negative regulation of MAPK cascade | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. [GOC:go_curators] |