Page last updated: 2024-08-07 18:45:12
Sterol 14-alpha demethylase
A protein that is a translation product of any of the 2 copies of the CYP51 gene in Trypanosoma cruzi strain CL Brener. [PRO:DNx, UniProtKB:Q7Z1V1]
Synonyms
Tc14DM;
EC 1.14.14.154;
Cytochrome P450 51;
Lanosterol 14-alpha demethylase
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
Compounds (10)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| fluconazole | Trypanosoma cruzi strain CL Brener | IC50 | 0.8800 | 1 | 1 |
| cordycepin | Trypanosoma cruzi strain CL Brener | IC50 | 100.0000 | 1 | 0 |
| tebuconazole | Trypanosoma cruzi strain CL Brener | IC50 | 0.1259 | 1 | 0 |
| corydaline | Trypanosoma cruzi strain CL Brener | IC50 | 79.4328 | 1 | 0 |
| albaconazole | Trypanosoma cruzi strain CL Brener | IC50 | 0.0010 | 1 | 1 |
| ketoconazole | Trypanosoma cruzi strain CL Brener | IC50 | 0.0140 | 1 | 1 |
| posaconazole | Trypanosoma cruzi strain CL Brener | IC50 | 0.4640 | 2 | 2 |
| N-(1,3-benzodioxol-5-yl)-2-[[3-(2-methoxyphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]thio]acetamide | Trypanosoma cruzi strain CL Brener | IC50 | 63.0957 | 1 | 0 |
| 2-(1,3-benzodioxol-5-yl)-5-[[2-(4-methoxyphenyl)-4,5-dihydrothiazol-5-yl]methylthio]-1,3,4-oxadiazole | Trypanosoma cruzi strain CL Brener | IC50 | 10.0000 | 1 | 0 |
| formycin b | Trypanosoma cruzi strain CL Brener | IC50 | 100.0000 | 1 | 0 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| fluconazole | Trypanosoma cruzi strain CL Brener | Kd | 0.2575 | 3 | 4 |
| ketoconazole | Trypanosoma cruzi strain CL Brener | Kd | 1.1600 | 1 | 2 |
| posaconazole | Trypanosoma cruzi strain CL Brener | Kd | 0.0390 | 2 | 2 |