Proteins > Sterol 14-alpha demethylase
Page last updated: 2024-08-07 18:45:12

Sterol 14-alpha demethylase

A protein that is a translation product of any of the 2 copies of the CYP51 gene in Trypanosoma cruzi strain CL Brener. [PRO:DNx, UniProtKB:Q7Z1V1]

Synonyms

Tc14DM;
EC 1.14.14.154;
Cytochrome P450 51;
Lanosterol 14-alpha demethylase

Research

Bioassay Publications (8)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's4 (50.00)24.3611
2020's3 (37.50)2.80

Compounds (10)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
fluconazoleTrypanosoma cruzi strain CL BrenerIC500.880011
cordycepinTrypanosoma cruzi strain CL BrenerIC50100.000010
tebuconazoleTrypanosoma cruzi strain CL BrenerIC500.125910
corydalineTrypanosoma cruzi strain CL BrenerIC5079.432810
albaconazoleTrypanosoma cruzi strain CL BrenerIC500.001011
ketoconazoleTrypanosoma cruzi strain CL BrenerIC500.014011
posaconazoleTrypanosoma cruzi strain CL BrenerIC500.464022
N-(1,3-benzodioxol-5-yl)-2-[[3-(2-methoxyphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]thio]acetamideTrypanosoma cruzi strain CL BrenerIC5063.095710
2-(1,3-benzodioxol-5-yl)-5-[[2-(4-methoxyphenyl)-4,5-dihydrothiazol-5-yl]methylthio]-1,3,4-oxadiazoleTrypanosoma cruzi strain CL BrenerIC5010.000010
formycin bTrypanosoma cruzi strain CL BrenerIC50100.000010

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
fluconazoleTrypanosoma cruzi strain CL BrenerKd0.257534
ketoconazoleTrypanosoma cruzi strain CL BrenerKd1.160012
posaconazoleTrypanosoma cruzi strain CL BrenerKd0.039022