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Nitric oxide synthase, brain
A nitric oxide synthase 1 that is encoded in the genome of rat. [OMA:P29476, PRO:DNx]
Synonyms
EC 1.14.13.39;
BNOS;
Constitutive NOS;
NC-NOS;
NOS type I;
Neuronal NOS;
N-NOS;
nNOS;
Peptidyl-cysteine S-nitrosylase NOS1
Research
Bioassay Publications (21)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 9 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (21)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| guanethidine | Rattus norvegicus (Norway rat) | Activity | 0.1000 | 1 | 1 |
| arginine | Rattus norvegicus (Norway rat) | Km | 2.7000 | 1 | 1 |
| guanoxan | Rattus norvegicus (Norway rat) | Activity | 0.1000 | 1 | 1 |
| guanadrel | Rattus norvegicus (Norway rat) | Activity | 0.1000 | 1 | 1 |
| 4-nitrocatechol | Rattus norvegicus (Norway rat) | Km | 16.0000 | 1 | 1 |
Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.European journal of medicinal chemistry, , Volume: 44, Issue:7, 2009
Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.Bioorganic & medicinal chemistry, , Jun-01, Volume: 16, Issue:11, 2008
4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 17, Issue:11, 2007
Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles.Bioorganic & medicinal chemistry letters, , May-07, Volume: 11, Issue:9, 2001
A new class of selective and potent inhibitors of neuronal nitric oxide synthase.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 9, Issue:17, 1999
Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.Biochemistry, , Sep-15, Volume: 48, Issue:36, 2009
Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.Journal of medicinal chemistry, , Apr-25, Volume: 56, Issue:8, 2013
Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.Biochemistry, , Sep-15, Volume: 48, Issue:36, 2009
Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.Journal of medicinal chemistry, , Jul-02, Volume: 41, Issue:14, 1998
Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.Journal of medicinal chemistry, , Nov-11, Volume: 53, Issue:21, 2010
L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.Journal of medicinal chemistry, , Jul-23, Volume: 52, Issue:14, 2009
Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.Journal of medicinal chemistry, , Jul-02, Volume: 41, Issue:14, 1998