Page last updated: 2024-08-07 16:23:34
Nitric oxide synthase, brain
A nitric oxide synthase 1 that is encoded in the genome of rat. [OMA:P29476, PRO:DNx]
Synonyms
EC 1.14.13.39;
BNOS;
Constitutive NOS;
NC-NOS;
NOS type I;
Neuronal NOS;
N-NOS;
nNOS;
Peptidyl-cysteine S-nitrosylase NOS1
Research
Bioassay Publications (21)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 9 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (21)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 1-(2-trifluoromethylphenyl)imidazole | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| n-(3-(aminomethyl)benzyl)acetamidine | Rattus norvegicus (Norway rat) | IC50 | 7.5500 | 2 | 2 |
| 2-amino-4-picoline | Rattus norvegicus (Norway rat) | IC50 | 0.0400 | 1 | 1 |
| 3-bromo-7-nitroindazole | Rattus norvegicus (Norway rat) | IC50 | 1.8000 | 1 | 1 |
| 7-nitroindazole | Rattus norvegicus (Norway rat) | IC50 | 11.1040 | 5 | 5 |
| econazole | Rattus norvegicus (Norway rat) | IC50 | 20.1450 | 1 | 0 |
| econazole | Rattus norvegicus (Norway rat) | Ki | 10.9880 | 1 | 0 |
| citrulline | Rattus norvegicus (Norway rat) | Ki | 2,350.0000 | 1 | 2 |
| alpha-aminopyridine | Rattus norvegicus (Norway rat) | IC50 | 9.0000 | 2 | 2 |
| n-(4-nitrophenacyl)imidazole | Rattus norvegicus (Norway rat) | Ki | 105.0000 | 1 | 1 |
| 3-indazolinone | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| 2-aminoimidazole | Rattus norvegicus (Norway rat) | IC50 | 65.0000 | 1 | 1 |
| s-methylthiocitrulline | Rattus norvegicus (Norway rat) | IC50 | 0.0600 | 1 | 1 |
| s-methylthiocitrulline | Rattus norvegicus (Norway rat) | Ki | 0.0500 | 1 | 1 |
| n(g)-iminoethylornithine | Rattus norvegicus (Norway rat) | Ki | 495.8500 | 1 | 2 |
| n,n-dimethylarginine | Rattus norvegicus (Norway rat) | Ki | 0.7000 | 1 | 1 |
| omega-n-methylarginine | Rattus norvegicus (Norway rat) | IC50 | 7.5000 | 1 | 1 |
| omega-n-methylarginine | Rattus norvegicus (Norway rat) | Ki | 503.8667 | 2 | 6 |
| nitroarginine | Rattus norvegicus (Norway rat) | IC50 | 4.1200 | 5 | 5 |
| nitroarginine | Rattus norvegicus (Norway rat) | Ki | 4.5500 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| guanethidine | Rattus norvegicus (Norway rat) | Activity | 0.1000 | 1 | 1 |
| arginine | Rattus norvegicus (Norway rat) | Km | 2.7000 | 1 | 1 |
| guanoxan | Rattus norvegicus (Norway rat) | Activity | 0.1000 | 1 | 1 |
| guanadrel | Rattus norvegicus (Norway rat) | Activity | 0.1000 | 1 | 1 |
| 4-nitrocatechol | Rattus norvegicus (Norway rat) | Km | 16.0000 | 1 | 1 |