Page last updated: 2024-08-07 15:43:23
Carbonic anhydrase 3
A carbonic anhydrase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07451]
Synonyms
EC 4.2.1.1;
Carbonate dehydratase III;
Carbonic anhydrase III;
CA-III
Research
Bioassay Publications (64)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (3.13) | 18.7374 |
| 1990's | 2 (3.13) | 18.2507 |
| 2000's | 25 (39.06) | 29.6817 |
| 2010's | 32 (50.00) | 24.3611 |
| 2020's | 3 (4.69) | 2.80 |
Compounds (108)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 4-hydroxybenzoic acid | Homo sapiens (human) | Ki | 295.2006 | 3 | 16 |
| cadaverine | Homo sapiens (human) | Ki | 0.5000 | 1 | 1 |
| catechol | Homo sapiens (human) | Ki | 401.9357 | 3 | 14 |
| coumarin | Homo sapiens (human) | Ki | 102.8000 | 2 | 2 |
| salicylic acid | Homo sapiens (human) | Ki | 224.3786 | 2 | 14 |
| gallic acid | Homo sapiens (human) | Ki | 7.4900 | 1 | 1 |
| 4-aminophenol | Homo sapiens (human) | Ki | 479.5429 | 2 | 14 |
| hydroquinone | Homo sapiens (human) | Ki | 116.9779 | 2 | 14 |
| phenol | Homo sapiens (human) | Ki | 152.7625 | 5 | 16 |
| spermidine | Homo sapiens (human) | Ki | 11.5000 | 1 | 1 |
| spermine | Homo sapiens (human) | Ki | 167.0000 | 1 | 1 |
| catechin | Homo sapiens (human) | Ki | 3.5800 | 1 | 1 |
| acetaminophen | Homo sapiens (human) | Ki | 147.8923 | 2 | 13 |
| acetazolamide | Homo sapiens (human) | IC50 | 1.9500 | 4 | 4 |
| acetazolamide | Homo sapiens (human) | Ki | 74.9860 | 38 | 83 |
| bumetanide | Homo sapiens (human) | Ki | 18.3242 | 1 | 12 |
| celecoxib | Homo sapiens (human) | Ki | 77.1333 | 3 | 3 |
| chlorthalidone | Homo sapiens (human) | Ki | 2.8665 | 2 | 14 |
| coumaphos | Homo sapiens (human) | Ki | 4.6200 | 1 | 1 |
| dichlorphenamide | Homo sapiens (human) | Ki | 187.9782 | 6 | 19 |
| ethoxzolamide | Homo sapiens (human) | Ki | 661.8093 | 7 | 10 |
| furosemide | Homo sapiens (human) | Ki | 471.6824 | 2 | 14 |
| hydrochlorothiazide | Homo sapiens (human) | Ki | 18.6042 | 1 | 12 |
| hydroflumethiazide | Homo sapiens (human) | Ki | 20.3203 | 1 | 12 |
| indapamide | Homo sapiens (human) | Ki | 51.6009 | 2 | 14 |
| mafenide | Homo sapiens (human) | Ki | 681.0000 | 1 | 1 |
| methazolamide | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| methazolamide | Homo sapiens (human) | Ki | 496.6679 | 7 | 9 |
| metolazone | Homo sapiens (human) | Ki | 22.0639 | 1 | 12 |
| resorcinol | Homo sapiens (human) | Ki | 320.9286 | 2 | 14 |
| resveratrol | Homo sapiens (human) | Ki | 6.7500 | 1 | 1 |
| saccharin | Homo sapiens (human) | Ki | 1,000.0000 | 1 | 1 |
| imatinib | Homo sapiens (human) | Ki | 0.5280 | 1 | 1 |
| sulfanilamide | Homo sapiens (human) | Ki | 362.9960 | 3 | 3 |
| sulpiride | Homo sapiens (human) | Ki | 10.6000 | 1 | 1 |
| sulthiame | Homo sapiens (human) | Ki | 52.8233 | 1 | 12 |
| trichlormethiazide | Homo sapiens (human) | Ki | 86.8264 | 2 | 26 |
| trientine | Homo sapiens (human) | Ki | 48.0000 | 1 | 1 |
| zonisamide | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| zonisamide | Homo sapiens (human) | Ki | 442.8417 | 3 | 15 |
| carbostyril | Homo sapiens (human) | Ki | 0.5700 | 2 | 2 |
| 4-toluenesulfonamide | Homo sapiens (human) | Ki | 7.9000 | 1 | 1 |
| quinethazone | Homo sapiens (human) | Ki | 18.1300 | 1 | 2 |
| benzenesulfonamide | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| diethylenetriamine | Homo sapiens (human) | Ki | 117.0000 | 1 | 1 |
| neoprontosil | Homo sapiens (human) | Ki | 2.3000 | 1 | 1 |
| carzenide | Homo sapiens (human) | Ki | 11.3000 | 1 | 1 |
| syringic acid | Homo sapiens (human) | Ki | 8.5800 | 1 | 1 |
| herniarin | Homo sapiens (human) | Ki | 96.0000 | 1 | 1 |
| coumarin-3-carboxylic acid | Homo sapiens (human) | Ki | 6.6000 | 1 | 1 |
| 4-cyanophenol | Homo sapiens (human) | Ki | 202.9649 | 2 | 14 |
| n-(1-naphthyl)ethylenediamine | Homo sapiens (human) | Ki | 0.4200 | 1 | 1 |
| 1,6-diaminohexane | Homo sapiens (human) | Ki | 0.6000 | 1 | 1 |
| benzolamide | Homo sapiens (human) | Ki | 30.8859 | 2 | 5 |
| 7-ethoxycoumarin | Homo sapiens (human) | Ki | 500.0000 | 1 | 1 |
| dobutamine | Homo sapiens (human) | Ki | 7.4000 | 1 | 1 |
| 4-chlorobenzenesulfonamide | Homo sapiens (human) | Ki | 0.0003 | 1 | 1 |
| benzeneboronic acid | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| 4-amino-6-chloro-1,3-benzenedisulfonamide | Homo sapiens (human) | Ki | 9.7000 | 1 | 1 |
| brinzolamide | Homo sapiens (human) | Ki | 110.0000 | 2 | 2 |
| 2,4-disulfamyl-5-trifluoromethylaniline | Homo sapiens (human) | Ki | 1,276.0000 | 1 | 1 |
| methanesulfonamide | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 2-aminobenzenesulfonamide | Homo sapiens (human) | Ki | 887.0000 | 1 | 1 |
| 3,7-diazanonane-1,9-diamine | Homo sapiens (human) | Ki | 63.0000 | 1 | 1 |
| sulfamide | Homo sapiens (human) | Ki | 1,090.0000 | 1 | 1 |
| 5-amino-1,3,4-thiadiazole-2-sulfonamide | Homo sapiens (human) | Ki | 149.0000 | 2 | 2 |
| valdecoxib | Homo sapiens (human) | Ki | 433.0000 | 2 | 2 |
| 1-naphthylacetylspermine | Homo sapiens (human) | Ki | 11.6000 | 1 | 1 |
| chlorzolamide | Homo sapiens (human) | Ki | 14.6000 | 1 | 1 |
| 4-(2-aminoethyl)benzenesulfonamide | Homo sapiens (human) | Ki | 1,600.0000 | 1 | 1 |
| n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide | Homo sapiens (human) | Ki | 10.4000 | 1 | 1 |
| lacosamide | Homo sapiens (human) | Ki | 0.3740 | 1 | 1 |
| bortezomib | Homo sapiens (human) | Ki | 4.5700 | 1 | 1 |
| resveratrol | Homo sapiens (human) | Ki | 9.0900 | 1 | 1 |
| ferulic acid | Homo sapiens (human) | Ki | 11.1000 | 1 | 1 |
| hydroxyphenethylferulate | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| 2-hydroxycinnamic acid | Homo sapiens (human) | Ki | 1,000.0000 | 1 | 1 |
| trans-4-coumaric acid | Homo sapiens (human) | Ki | 7.5700 | 1 | 1 |
| s 1033 | Homo sapiens (human) | Ki | 0.4430 | 1 | 1 |
| caffeic acid | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| 7-methoxy-2-oxo-1-benzopyran-3-carboxylic acid ethyl ester | Homo sapiens (human) | Ki | 71.7000 | 1 | 1 |
| 2,6-dibromosulfanilamide | Homo sapiens (human) | Ki | 10.7000 | 1 | 1 |
| quercetin | Homo sapiens (human) | Ki | 8.1000 | 1 | 1 |
| ellagic acid | Homo sapiens (human) | Ki | 10.5000 | 1 | 1 |
| dorzolamide | Homo sapiens (human) | Ki | 196.6686 | 5 | 16 |
| topiramate | Homo sapiens (human) | Ki | 244.1792 | 5 | 16 |
| irosustat | Homo sapiens (human) | Ki | 108.2698 | 2 | 13 |
| famotidine | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| dodoneine | Homo sapiens (human) | Ki | 10.3500 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.Journal of medicinal chemistry, , Jan-14, Volume: 53, Issue:1, 2010
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.Journal of medicinal chemistry, , 02-11, Volume: 64, Issue:3, 2021
Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Famotidine, an Antiulcer Agent, Strongly Inhibits ACS medicinal chemistry letters, , Oct-11, Volume: 9, Issue:10, 2018
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases.Journal of medicinal chemistry, , Sep-24, Volume: 58, Issue:18, 2015
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Dec-15, Volume: 22, Issue:24, 2014
Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.Journal of medicinal chemistry, , Nov-26, Volume: 57, Issue:22, 2014
Inhibition of human carbonic anhydrase isoforms I-XIV with sulfonamides incorporating fluorine and 1,3,5-triazine moieties.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition.Bioorganic & medicinal chemistry, , Apr-15, Volume: 21, Issue:8, 2013
Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 22, Issue:4, 2012
Acetaldehyde-derived modifications on cytosolic human carbonic anhydrases.Journal of enzyme inhibition and medicinal chemistry, , Volume: 26, Issue:6, 2011
Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.Bioorganic & medicinal chemistry, , Jun-15, Volume: 19, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 18, Issue:14, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Acetazolamide-like carbonic anhydrase inhibitors with topical ocular hypotensive activity.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
N-Substituted sulfonamide carbonic anhydrase inhibitors with topical effects on intraocular pressure.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies.Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:4, 2014
Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.Bioorganic & medicinal chemistry, , Jun-15, Volume: 19, Issue:12, 2011
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.Bioorganic & medicinal chemistry, , Jun-15, Volume: 19, Issue:12, 2011
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Substituted thieno[2,3-b]thiophenes and related congeners: Synthesis, β-glucuronidase inhibition activity, crystal structure, and POM analyses.Bioorganic & medicinal chemistry, , Dec-01, Volume: 22, Issue:23, 2014
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?Chemical biology & drug design, , Volume: 74, Issue:3, 2009
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| carbonate dehydratase activity | molecular function | Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. [EC:4.2.1.1] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| nickel cation binding | molecular function | Binding to a nickel (Ni) cation. [GOC:ai] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
Involved In
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|
| response to bacterium | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. [GOC:hb] |
| one-carbon metabolic process | biological process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. [GOC:hjd, GOC:mah, GOC:pde] |