A sodium channel protein type 8 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UQD0]
Sodium channel protein type VIII subunit alpha;
Voltage-gated sodium channel subunit alpha Nav1.6
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| amiodarone | Homo sapiens (human) | IC50 | 4.8000 | 1 | 1 |
| amitriptyline | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| chlorpromazine | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| cifenline | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| haloperidol | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| imipramine | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| mexiletine | Homo sapiens (human) | IC50 | 43.0000 | 1 | 1 |
| nifedipine | Homo sapiens (human) | IC50 | 37.0000 | 1 | 1 |
| nitrendipine | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| tetracaine | Homo sapiens (human) | IC50 | 0.5200 | 1 | 1 |
| pimozide | Homo sapiens (human) | IC50 | 0.0540 | 1 | 1 |
| diltiazem | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| sertindole | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| mibefradil | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| tedisamil | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| uk 68798 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| senicapoc | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| ica-121431 | Homo sapiens (human) | IC50 | 10.1500 | 2 | 2 |
| tetrodotoxin | Homo sapiens (human) | IC50 | 0.0161 | 2 | 2 |
| cnv1014802 | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| saxitoxin | Homo sapiens (human) | IC50 | 0.0011 | 1 | 1 |
| ajmaline | Homo sapiens (human) | IC50 | 8.2000 | 1 | 1 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated sodium channel activity | molecular function | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| sodium ion binding | molecular function | Binding to a sodium ion (Na+). [GOC:mah] |
This protein is located in 12 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| Z disc | cellular component | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. [GOC:mtg_muscle, ISBN:0815316194] |
| cell junction | cellular component | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264] |
| axon | cellular component | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732] |
| cytoplasmic vesicle | cellular component | A vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles] |
| node of Ranvier | cellular component | An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. [GOC:mh] |
| axon initial segment | cellular component | Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. [GOC:nln, GOC:sl, PMID:1754851, PMID:21551097] |
| presynaptic active zone membrane | cellular component | The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters. [PMID:12812759, PMID:12923177, PMID:3152289] |
| parallel fiber to Purkinje cell synapse | cellular component | An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells. [PMID:16623829, PMID:3209740] |
| postsynaptic density membrane | cellular component | The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos] |
| glutamatergic synapse | cellular component | A synapse that uses glutamate as a neurotransmitter. [GOC:dos] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated sodium channel complex | cellular component | A sodium channel in a cell membrane whose opening is governed by the membrane potential. [ISBN:0198506732] |
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| sodium ion transport | biological process | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| nervous system development | biological process | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh] |
| peripheral nervous system development | biological process | The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. [GOC:go_curators, UBERON:0000010] |
| neuronal action potential | biological process | An action potential that occurs in a neuron. [GOC:dph, GOC:isa_complete, GOC:tb] |
| optic nerve development | biological process | The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] |
| myelination | biological process | The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. [GOC:dgh, GOC:mah] |
| sodium ion transmembrane transport | biological process | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw] |
| cardiac muscle cell action potential involved in contraction | biological process | An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |