Proteins > Tyrosine-protein kinase Fgr
Page last updated: 2024-08-07 15:49:47

Tyrosine-protein kinase Fgr

A tyrosine-protein kinase Fgr that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09769]

Synonyms

EC 2.7.10.2;
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog;
Proto-oncogene c-Fgr;
p55-Fgr;
p58-Fgr;
p58c-Fgr

Research

Bioassay Publications (19)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (47.37)29.6817
2010's9 (47.37)24.3611
2020's1 (5.26)2.80

Compounds (125)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
1,4-diaminoanthraquinoneHomo sapiens (human)IC5024.000011
staurosporineHomo sapiens (human)IC500.000922
birb 796Homo sapiens (human)IC508.500011
bosutinibHomo sapiens (human)IC500.001111
a 770041Homo sapiens (human)IC5014.100011
abt 869Homo sapiens (human)IC50500.000011
crizotinibHomo sapiens (human)IC5010.000011
amg 458Homo sapiens (human)IC500.328011
pci 32765Homo sapiens (human)IC500.002122
gdc 0980Homo sapiens (human)IC500.697011
rn486Homo sapiens (human)IC500.180011
ceritinibHomo sapiens (human)IC501.947011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
fasudilHomo sapiens (human)Kd30.000011
sb 202190Homo sapiens (human)Kd10.000011
imatinibHomo sapiens (human)Kd11.600033
triciribine phosphateHomo sapiens (human)Kd30.000012
staurosporineHomo sapiens (human)Kd0.021333
gefitinibHomo sapiens (human)Kd14.200033
lestaurtinibHomo sapiens (human)Kd10.034733
vatalanibHomo sapiens (human)Kd16.666733
ruboxistaurinHomo sapiens (human)Kd10.000022
canertinibHomo sapiens (human)Kd2.433333
birb 796Homo sapiens (human)Kd10.000022
cyc 202Homo sapiens (human)Kd20.000022
sb 203580Homo sapiens (human)Kd10.000022
enzastaurinHomo sapiens (human)Kd10.000011
erlotinibHomo sapiens (human)Kd10.733333
lapatinibHomo sapiens (human)Kd16.666733
sorafenibHomo sapiens (human)Kd9.266733
pd 173955Homo sapiens (human)Kd0.002411
s 1033Homo sapiens (human)Kd0.320011
bms 387032Homo sapiens (human)Kd10.000022
tandutinibHomo sapiens (human)Kd15.000044
vx-745Homo sapiens (human)Kd1.266733
dasatinibHomo sapiens (human)Kd0.002033
zd 6474Homo sapiens (human)Kd8.185044
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamideHomo sapiens (human)Kd10.000011
sirolimusHomo sapiens (human)Kd30.000011
alvocidibHomo sapiens (human)Kd16.666733
bosutinibHomo sapiens (human)Kd0.006311
orantinibHomo sapiens (human)Kd30.000011
su 11248Homo sapiens (human)Kd0.484766
jnj-7706621Homo sapiens (human)Kd2.000011
vx680Homo sapiens (human)Kd10.526733
cyc 116Homo sapiens (human)Kd30.000011
everolimusHomo sapiens (human)Kd30.000011
ekb 569Homo sapiens (human)Kd0.950011
axitinibHomo sapiens (human)Kd1.221022
temsirolimusHomo sapiens (human)Kd30.000011
pd 184352Homo sapiens (human)Kd10.000011
on 01910Homo sapiens (human)Kd30.000011
cp 547632Homo sapiens (human)Kd30.000011
bms345541Homo sapiens (human)Kd10.000011
pd 0325901Homo sapiens (human)Kd30.000011
midostaurinHomo sapiens (human)Kd0.730033
osi 930Homo sapiens (human)Kd30.000011
ki 20227Homo sapiens (human)Kd1.800011
cp 724714Homo sapiens (human)Kd10.000011
pi103Homo sapiens (human)Kd10.000022
hmn-214Homo sapiens (human)Kd30.000011
hki 272Homo sapiens (human)Kd1.900011
tofacitinibHomo sapiens (human)Kd10.000022
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamideHomo sapiens (human)Kd10.000011
cediranibHomo sapiens (human)Kd15.550022
masitinibHomo sapiens (human)Kd0.640011
pazopanibHomo sapiens (human)Kd1.600022
azd 6244Homo sapiens (human)Kd20.000022
su 14813Homo sapiens (human)Kd10.260033
bibw 2992Homo sapiens (human)Kd20.000022
binimetinibHomo sapiens (human)Kd30.000011
saracatinibHomo sapiens (human)Kd0.956011
tg100-115Homo sapiens (human)Kd20.000022
volasertibHomo sapiens (human)Kd30.000011
pha 665752Homo sapiens (human)Kd1.900011
regorafenibHomo sapiens (human)Kd30.000011
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd0.033011
brivanibHomo sapiens (human)Kd20.000022
at 7519Homo sapiens (human)Kd10.000011
bi 2536Homo sapiens (human)Kd20.000022
nvp-ast487Homo sapiens (human)Kd0.190022
kw 2449Homo sapiens (human)Kd0.440011
abt 869Homo sapiens (human)Kd10.000022
gw 2580Homo sapiens (human)Kd10.000022
idelalisibHomo sapiens (human)Kd30.000012
crizotinibHomo sapiens (human)Kd15.335022
chir-265Homo sapiens (human)Kd10.000022
motesanibHomo sapiens (human)Kd6.900022
trametinibHomo sapiens (human)Kd30.000011
mln8054Homo sapiens (human)Kd10.146733
GDC-0879Homo sapiens (human)Kd10.000011
bgt226Homo sapiens (human)Kd30.000011
gsk 461364Homo sapiens (human)Kd20.000022
azd 1152-hqpaHomo sapiens (human)Kd10.000022
nvp-tae684Homo sapiens (human)Kd0.120011
enmd 2076Homo sapiens (human)Kd30.000011
e 7050Homo sapiens (human)Kd30.000011
azd8330Homo sapiens (human)Kd30.000011
fedratinibHomo sapiens (human)Kd0.082011
gsk690693Homo sapiens (human)Kd20.000022
pf 04217903Homo sapiens (human)Kd30.000011
gdc 0941Homo sapiens (human)Kd20.000022
icotinibHomo sapiens (human)Kd30.000011
ph 797804Homo sapiens (human)Kd30.000011
kx-01Homo sapiens (human)Kd30.000011
plx 4720Homo sapiens (human)Kd0.062011
mk 5108Homo sapiens (human)Kd30.000011
cudc 101Homo sapiens (human)Kd30.000011
sgx 523Homo sapiens (human)Kd10.000011
ponatinibHomo sapiens (human)Kd0.038011
AMG-208Homo sapiens (human)Kd30.000011
quizartinibHomo sapiens (human)Kd16.666733
at13148Homo sapiens (human)Kd30.000011
dcc-2036Homo sapiens (human)Kd30.000011
incb-018424Homo sapiens (human)Kd20.000022
gsk 1838705aHomo sapiens (human)Kd10.000011
azd2014Homo sapiens (human)Kd30.000011
plx4032Homo sapiens (human)Kd30.000011
gsk 1363089Homo sapiens (human)Kd0.040011
as 703026Homo sapiens (human)Kd30.000011
dabrafenibHomo sapiens (human)Kd1.549011
pha 793887Homo sapiens (human)Kd30.000011
mk-8776Homo sapiens (human)Kd30.000011
gsk 1070916Homo sapiens (human)Kd30.000011
jnj38877605Homo sapiens (human)Kd30.000011
alectinibHomo sapiens (human)Kd30.000011
debio 1347Homo sapiens (human)Kd30.000011
at 9283Homo sapiens (human)Kd1.537011
chir 258Homo sapiens (human)Kd15.095034
nintedanibHomo sapiens (human)Kd15.150022
pp242Homo sapiens (human)Kd0.160011

Enables

This protein enables 9 target(s):

TargetCategoryDefinition
phosphotyrosine residue bindingmolecular functionBinding to a phosphorylated tyrosine residue within a protein. [PMID:14636584]
protein tyrosine kinase activitymolecular functionCatalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [RHEA:10596]
non-membrane spanning protein tyrosine kinase activitymolecular functionCatalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. [EC:2.7.10.2]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
protein kinase bindingmolecular functionBinding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
immunoglobulin receptor bindingmolecular functionBinding to one or more specific sites on an immunoglobulin receptor molecule. [GOC:BHF, GOC:vk]
Fc-gamma receptor I complex bindingmolecular functionBinding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG. [GOC:BHF, GOC:vk]
signaling receptor bindingmolecular functionBinding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]

Located In

This protein is located in 8 target(s):

TargetCategoryDefinition
extracellular regioncellular componentThe space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
mitochondrial inner membranecellular componentThe inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]
mitochondrial intermembrane spacecellular componentThe region between the inner and outer lipid bilayers of the mitochondrial envelope. [GOC:mah]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
aggresomecellular componentAn inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. [PMID:11121744]
secretory granule lumencellular componentThe volume enclosed by the membrane of a secretory granule. [GOC:rph]
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 24 target(s):

TargetCategoryDefinition
positive regulation of cytokine productionbiological processAny process that activates or increases the frequency, rate or extent of production of a cytokine. [GOC:add, ISBN:0781735149]
immune response-regulating cell surface receptor signaling pathwaybiological processThe series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response. [GOC:add, ISBN:0781735149, PMID:15771571]
negative regulation of inflammatory response to antigenic stimulusbiological processAny process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. [GOC:add]
protein phosphorylationbiological processThe process of introducing a phosphate group on to a protein. [GOC:hb]
integrin-mediated signaling pathwaybiological processThe series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
regulation of cell shapebiological processAny process that modulates the surface configuration of a cell. [GOC:dph, GOC:go_curators, GOC:tb]
response to virusbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. [GOC:hb]
peptidyl-tyrosine phosphorylationbiological processThe phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. [RESID:AA0039]
bone mineralizationbiological processThe deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. [GOC:mah, PMID:22936354]
positive regulation of cell migrationbiological processAny process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
negative regulation of natural killer cell activationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation. [GOC:mah]
Fc-gamma receptor signaling pathway involved in phagocytosisbiological processAn Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes. [GOC:phg, PMID:12488490, PMID:15466916]
positive regulation of mast cell degranulationbiological processAny process that activates or increases the frequency, rate or extent of mast cell degranulation. [ISBN:0781735149]
regulation of innate immune responsebiological processAny process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. [GOC:ebc]
regulation of protein kinase activitybiological processAny process that modulates the frequency, rate or extent of protein kinase activity. [GOC:go_curators]
protein autophosphorylationbiological processThe phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). [ISBN:0198506732]
skeletal system morphogenesisbiological processThe process in which the anatomical structures of the skeleton are generated and organized. [GOC:dph, GOC:dsf, GOC:jid, GOC:tb]
regulation of phagocytosisbiological processAny process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. [GOC:ai]
defense response to Gram-positive bacteriumbiological processReactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. [GOC:ai]
myoblast proliferationbiological processThe multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:ai, GOC:mtg_muscle]
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionbiological processAny process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
cell surface receptor protein tyrosine kinase signaling pathwaybiological processThe series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]
cell differentiationbiological processThe cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
innate immune responsebiological processInnate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]