chlorpromazine has been researched along with Necrosis in 43 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorpromazine administered to Sprague-Dawley rats 30 minutes prior to elevation of McFarlane back flaps and continued 14 days thereafter resulted in near complete flap survival, compared with 48 percent necrosis in control animals." | 7.67 | Prevention of flap necrosis by chlorpromazine. ( Bibi, R; Ferder, M; Strauch, B, 1986) |
| "The effects of treatment with chlorpromazine (4 mg/kg) and phenoxybenzamine (1 and 5 mg/kg) on renal function and morphology after warm ischemia and contralateral nephrectomy were studied." | 7.66 | Recovery of renal function after warm ischemia. I. The effect of chlorpromazine and phenoxybenzamine. ( Birrell, C; Howden, B; Jablonski, P; Leslie, E; Marshall, VC; Rae, D; Tange, J, 1983) |
| " The dosage was 1." | 5.28 | Can chlorpromazine prevent flap necrosis? ( Höft, HD; Oswald, P; Schumann, D; Tilgner, A, 1990) |
| "In a comparison with non-irradiated cells, significant apoptosis was found in TCSA, bithionol, chlorpromazine, sparfloxacin and enoxacin at 10(-4) or 10(-5)M as well as 8-MOP as assessed by both annexin V and active caspase-3 stainings, while necrosis occurred in most of these chemicals at 10(-4)M." | 3.74 | Induction of keratinocyte apoptosis by photosensitizing chemicals plus UVA. ( Atarashi, K; Kobayashi, M; Kurita, M; Mori, K; Shimauchi, T; Tokura, Y, 2007) |
| "Ca2+ accumulates in the nucleus and DNA undergoes enzymatic cleavage into internucleosome-length fragments before acetaminophen and dimethylnitrosamine produce hepatic necrosis in vivo and toxic cell death in vitro." | 3.68 | Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen. ( Corcoran, GB; Gurule, MW; Kamendulis, LM; Ray, SD; Yorkin, RD, 1993) |
| "The thromboxane A2 (TXA2) plasma level in kappa-carrageenin (KC)-induced acronecrosis in the rat tail has been studied." | 3.68 | Thromboxane plasma level in kappa-carrageenin-induced acronecrosis of the tail in rats. ( Abbas, NA; Hirschelmann, R; Mest, HJ; Taube, C, 1991) |
| "In mongrel dogs with induced pancreatitis we studied the effects of the nonspecific phospholipase A2-inhibitors chlorpromazine, gabexate mesilate and CaNa2EDTA on the course of pancreatogenic shock and the intrapancreatic lysolecithin production." | 3.67 | [Phospholipase A2 inhibitors in hemorrhagic-necrotizing pancreatitis. Animal experiment evaluation of a new treatment concept]. ( Alles, JU; Kahle, M; Klein, U; König, W; Martin, U, 1985) |
| "The effects of treatment with chlorpromazine (4 mg/kg) and phenoxybenzamine (1 and 5 mg/kg) on renal function and morphology after warm ischemia and contralateral nephrectomy were studied." | 3.66 | Recovery of renal function after warm ischemia. I. The effect of chlorpromazine and phenoxybenzamine. ( Birrell, C; Howden, B; Jablonski, P; Leslie, E; Marshall, VC; Rae, D; Tange, J, 1983) |
| "Chlorpromazine (CPZ) is a phenothiazine, antipsychotic drug that has caused several idiosyncratic responses during its therapeutic use." | 1.31 | Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy? ( Buchweitz, JP; Bursian, SJ; Ganey, PE; Roth, RA, 2002) |
| " Pretreatment with CPZ partially protected these organs from the toxic effects of CdCl(2)." | 1.30 | The antagonistic effect of chlorpromazine on cadmium toxicity. ( El-Ashmawy, IM; Youssef, SA, 1999) |
| " The dosage was 1." | 1.28 | Can chlorpromazine prevent flap necrosis? ( Höft, HD; Oswald, P; Schumann, D; Tilgner, A, 1990) |
| "Chlorpromazine pretreatment was associated with significant (p less than 0." | 1.27 | Effect of chlorpromazine on myocardial damage in the calcium paradox. ( Rabkin, SW, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (76.74) | 18.7374 |
| 1990's | 7 (16.28) | 18.2507 |
| 2000's | 2 (4.65) | 29.6817 |
| 2010's | 1 (2.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vatakuti, S | 1 |
| Pennings, JL | 1 |
| Gore, E | 1 |
| Olinga, P | 1 |
| Groothuis, GM | 1 |
| GERBER, EL | 1 |
| KUBAT, K | 1 |
| PETZOLD, H | 1 |
| ZIMMERMANN, S | 1 |
| AMER, S | 1 |
| LEVKOVICH-SOKOLOVA, AP | 1 |
| Kurita, M | 1 |
| Shimauchi, T | 1 |
| Kobayashi, M | 1 |
| Atarashi, K | 1 |
| Mori, K | 1 |
| Tokura, Y | 1 |
| Selye, H | 3 |
| Pahk, US | 1 |
| Somogyi, A | 1 |
| Brumback, RA | 1 |
| Empting, L | 1 |
| Susag, ME | 1 |
| Staton, RD | 1 |
| Senoo, Y | 1 |
| Murakami, T | 1 |
| Kawakami, S | 1 |
| Teramoto, S | 1 |
| Jablonski, P | 1 |
| Howden, B | 1 |
| Leslie, E | 1 |
| Rae, D | 1 |
| Birrell, C | 1 |
| Marshall, VC | 1 |
| Tange, J | 1 |
| Godoy, HM | 1 |
| Diaz Gomez, MI | 1 |
| Castro, JA | 2 |
| O'Connor, M | 1 |
| Marzi, A | 1 |
| de Toranzo, EG | 1 |
| Faucher, L | 1 |
| Marcoux, D | 1 |
| Lucas-Heron, B | 1 |
| Schmitt, N | 1 |
| Ollivier, B | 1 |
| Ray, SD | 1 |
| Kamendulis, LM | 1 |
| Gurule, MW | 1 |
| Yorkin, RD | 1 |
| Corcoran, GB | 1 |
| El-Ashmawy, IM | 1 |
| Youssef, SA | 1 |
| Buchweitz, JP | 1 |
| Ganey, PE | 1 |
| Bursian, SJ | 1 |
| Roth, RA | 1 |
| Gopinath, G | 1 |
| Ford, EJ | 1 |
| Bianchi, L | 1 |
| De Groote, J | 1 |
| Desmet, V | 1 |
| Gedigk, P | 1 |
| Korb, G | 1 |
| Popper, H | 1 |
| Poulsen, H | 1 |
| Scheuer, PJ | 1 |
| Schmid, M | 1 |
| Thaler, H | 1 |
| Wepler, W | 1 |
| Abbas, NA | 1 |
| Taube, C | 1 |
| Hirschelmann, R | 1 |
| Mest, HJ | 1 |
| Zheng, JW | 1 |
| Höft, HD | 1 |
| Oswald, P | 1 |
| Tilgner, A | 1 |
| Schumann, D | 1 |
| Rabkin, SW | 1 |
| Davy, CW | 1 |
| Fulleylove, M | 1 |
| Edmunds, JG | 1 |
| Eichler, DA | 1 |
| Rushton, B | 1 |
| Tudor, RJ | 1 |
| Walker, JM | 1 |
| Kahle, M | 2 |
| König, H | 1 |
| Filler, RD | 1 |
| Sadanaga, KK | 1 |
| Ohnishi, ST | 1 |
| Brewton, RG | 1 |
| MacCabe, JA | 1 |
| Kaplowitz, N | 1 |
| Aw, TY | 1 |
| Simon, FR | 1 |
| Stolz, A | 1 |
| Laudanno, OM | 1 |
| Bodini, OA | 1 |
| San Miguel, P | 1 |
| Cesolari, JA | 1 |
| Capdopon, E | 1 |
| Bibi, R | 1 |
| Ferder, M | 1 |
| Strauch, B | 1 |
| Klein, U | 1 |
| König, W | 1 |
| Martin, U | 1 |
| Alles, JU | 1 |
| Wheatley, DN | 1 |
| Sims, P | 1 |
| Tartarini, S | 1 |
| Bartoli, GM | 1 |
| Gaudiano, A | 2 |
| Montorsi, F | 1 |
| Petti, G | 2 |
| Polizzi, M | 2 |
| Zimmerman, HJ | 1 |
| Bednár, B | 1 |
| Broch, E | 1 |
| Netkovszky, K | 1 |
| Severini, G | 1 |
| Bree, MM | 1 |
| Cohen, BJ | 1 |
| Abrams, GD | 1 |
| Tarján, G | 1 |
| Czeizel, E | 1 |
| Görgényi, F | 1 |
| Székesi, J | 1 |
| Ter-Grigorova, EN | 1 |
| Afanas'eva, VM | 1 |
| Ivanovskaia, TE | 1 |
| McLaughlin, RF | 1 |
| Tyler, WS | 1 |
| Edwards, DW | 1 |
| Crenshaw, GL | 1 |
| Canada, RO | 1 |
| Fowler, MA | 1 |
| Parker, EA | 1 |
| Reifenstein, GH | 1 |
3 reviews available for chlorpromazine and Necrosis
| Article | Year |
|---|---|
[MORPHOLOGICAL FINDINGS IN THE MYOCARDIUM AND SOME OTHER ORGANS AFTER DIRECT HYPOTHERMIA IN RATS AND DOGS].
Topics: Adrenal Glands; Animals; Brain; Chlorpromazine; Dogs; Hypothermia; Hypothermia, Induced; Kidney; Liv | 1963 |
[Prevention and treatment of flap necrosis by drugs].
Topics: Animals; Chlorpromazine; Graft Survival; Humans; Necrosis; Pentoxifylline; Reserpine; Skin; Surgical | 1990 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Bile; Bile Acids and Salts; Biotransformation; Cell Survival; Chemical and Drug Induc | 1986 |
40 other studies available for chlorpromazine and Necrosis
| Article | Year |
|---|---|
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.
Topics: Acetaminophen; Aged; Benzofurans; Bile Acids and Salts; Chloramphenicol; Chlorpromazine; Cholestasis | 2016 |
[A CASE OF NECROTIC NEPHROSIS IN AMINAZIN THERAPY].
Topics: Chlorpromazine; Geriatrics; Hypertension; Necrosis; Nephrosis; Obesity; Pathology; Shock; Shock, Sep | 1963 |
[THE EFFECT OF DIFFERENT SUBSTANCES ON ACUTE CARBON TETRACHLORIDE NECROSIS OF THE RAT LIVER].
Topics: Aspartate Aminotransferases; Blood Chemical Analysis; Carbon Tetrachloride; Carbon Tetrachloride Poi | 1965 |
[Morphological changes in a bullo-necrotic form of aminazin toxicodermatitis].
Topics: Chlorpromazine; Dermatitis; Drug Eruptions; Humans; Immune System Diseases; Necrosis | 1960 |
Induction of keratinocyte apoptosis by photosensitizing chemicals plus UVA.
Topics: Anesthetics, Local; Anti-Infective Agents, Local; Antipsychotic Agents; Antitubercular Agents; Apopt | 2007 |
Acute cutaneous necrosis following sensitization by heterologous blood.
Topics: Acetates; Animals; Blood Group Incompatibility; Blood Transfusion; Cats; Cattle; Chlorpromazine; Cri | 1967 |
Prevention of renal necrosis by stress.
Topics: Animals; Chlorpromazine; Cyproheptadine; Ischemia; Kidney Diseases; Necrosis; Rats; Stress, Physiolo | 1967 |
Muscle fibrosis associated with intramuscular chlorpromazine administration. A preliminary report.
Topics: Animals; Chlorpromazine; Humans; Injections, Intramuscular; Male; Middle Aged; Muscular Diseases; Ne | 1982 |
Changes in systemic redistribution of blood flow by vasodilators.
Topics: Animals; Blood Circulation; Blood Gas Analysis; Blood Pressure; Cardiac Output; Chlorpromazine; Dogs | 1984 |
Recovery of renal function after warm ischemia. I. The effect of chlorpromazine and phenoxybenzamine.
Topics: Animals; Chlorpromazine; Creatinine; Dose-Response Relationship, Drug; Glomerular Filtration Rate; I | 1983 |
Relationship between dimethylnitrosamine metabolism or activation and its ability to induce liver necrosis in rats.
Topics: Animals; Biotransformation; Chlorpromazine; Cystamine; Dimethylnitrosamine; Diphenhydramine; In Vitr | 1980 |
Muscle necrosis induced by intramuscular chlorpromazine.
Topics: Adult; Chlorpromazine; Humans; Injections, Intramuscular; Male; Muscles; Necrosis | 1980 |
Mechanism of chlorpromazine prevention of carbon tetrachloride-induced liver necrosis.
Topics: Animals; Body Temperature; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; C | 1980 |
What syndrome is this? Nicolau syndrome.
Topics: Child, Preschool; Chlorpromazine; Drug Eruptions; Erythema; Humans; Injections, Intramuscular; Leg U | 1995 |
Mdx mouse skeletal muscle: could a mitochondrial factor be responsible for the absence of progressive necrosis?
Topics: Animals; Calcium; Calcium Radioisotopes; Calcium-Binding Proteins; Calsequestrin; Chlorpromazine; El | 1994 |
Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen.
Topics: Acetaminophen; Animals; Biotransformation; Calcium; Calcium Channel Blockers; Cell Death; Chlorproma | 1993 |
The antagonistic effect of chlorpromazine on cadmium toxicity.
Topics: Animals; Cadmium Chloride; Chlorpromazine; Edema; Hemoglobins; Hemorrhage; Liver; Male; Necrosis; Or | 1999 |
Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy?
Topics: Animals; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; | 2002 |
The influence of hepatic microsomal amidopyrine demethylase activity on halothane hepatotoxicity in the horse.
Topics: Aminopyrine N-Demethylase; Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chlorp | 1976 |
[Rules for the histological evaluation of drug-induced liver lesions].
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Contraceptives, Oral; F | 1975 |
Thromboxane plasma level in kappa-carrageenin-induced acronecrosis of the tail in rats.
Topics: Animals; Aspirin; Carrageenan; Chlorpromazine; Dexamethasone; Heparin; Imidazoles; Naphthalenes; Nec | 1991 |
Can chlorpromazine prevent flap necrosis?
Topics: Animals; Chlorpromazine; Female; Graft Survival; Necrosis; Postoperative Complications; Rats; Rats, | 1990 |
Effect of chlorpromazine on myocardial damage in the calcium paradox.
Topics: Animals; Calcium; Chlorpromazine; Female; Myocardial Infarction; Myocardium; Necrosis; Rabbits | 1987 |
The diagnostic usefulness of isocitrate dehydrogenase (ICDH) in the marmoset (Callithrix jacchus).
Topics: Alanine Transaminase; Amino Acid Oxidoreductases; Animals; Aspartate Aminotransferases; Callithrix; | 1989 |
Lysolecithin concentration in pancreatic tissue during therapy with phospholipase A2-inhibitors in acute necrotizing pancreatitis.
Topics: Acute Disease; Animals; Chlorpromazine; Dogs; Dose-Response Relationship, Drug; Edetic Acid; Female; | 1989 |
Chlorpromazine protects rat spinal cord against contusion injury.
Topics: Animals; Arachnoid; Chlorpromazine; Contusions; Dura Mater; Male; Motor Activity; Necrosis; Permeabi | 1989 |
In vitro effects of calmodulin antagonists on macrophage function in the posterior necrotic zone of the chick wing.
Topics: Animals; Calmodulin; Cell Survival; Chick Embryo; Chlorpromazine; Culture Techniques; Macrophages; M | 1988 |
[Cytoprotection of gastric mucosa induced by tripotassium-dicitrato bismuthate against ethanol stress. Dependent mechanisms of sulfhydryl, dopaminergic and endogenous prostaglandin].
Topics: Acetazolamide; Animals; Chlorpromazine; Domperidone; Ethanol; Female; Gastric Mucosa; Indomethacin; | 1986 |
Prevention of flap necrosis by chlorpromazine.
Topics: Animals; Chlorpromazine; Graft Survival; Injections, Subcutaneous; Male; Necrosis; Rats; Rats, Inbre | 1986 |
[Phospholipase A2 inhibitors in hemorrhagic-necrotizing pancreatitis. Animal experiment evaluation of a new treatment concept].
Topics: Acute Disease; Animals; Chlorpromazine; Dogs; Edetic Acid; Female; Gabexate; Guanidines; Hemodynamic | 1985 |
Comparison of the efficacy of pretreatment protection against adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz(a)anthracene and by 7-methyl-12-methylbenz(a)anthracene in rats.
Topics: Adrenal Glands; Aminoglutethimide; Animals; Azo Compounds; Benz(a)Anthracenes; Chlorpromazine; Color | 1969 |
[Study of the changes of some enzyme activities in the liver of rats subjected to acute intoxication with allyl alcohol and of the effect of the preventive administration of chlorpromazine].
Topics: Alcohols; Animals; Cathepsins; Chemical and Drug Induced Liver Injury; Chlorpromazine; Electron Tran | 1968 |
The spectrum of hepatotoxicity.
Topics: Aminosalicylic Acids; Anti-Bacterial Agents; Antimetabolites; Benzene Derivatives; Carbon Tetrachlor | 1968 |
[Pathomorphology of toxic liver lesions].
Topics: Adult; Aflatoxins; Aged; Animals; Biopsy; Chemical and Drug Induced Liver Injury; Child; Chlorpromaz | 1973 |
[Action of some drugs on experimental liver necrosis].
Topics: Animals; Chlorpromazine; Cysteine; Injections, Intraperitoneal; Ischemia; Liver Diseases; Necrosis; | 1971 |
Injection lesions following intramuscular administration of chlorpromazine in rabbits.
Topics: Animals; Chlorpromazine; Inflammation; Injections, Intramuscular; Male; Muscular Diseases; Necrosis; | 1971 |
Ischemic necrosis: prevention by stress.
Topics: Animals; Chlorpromazine; Cold Temperature; Cordotomy; Epinephrine; Female; Hydrocortisone; Ischemia; | 1967 |
[Medicamentous prevention of endotoxin-induced mortality of pregnant animals].
Topics: Aminocaproates; Animals; Aprotinin; Chlorpromazine; Female; Fetal Death; Liver Diseases; Maternal Mo | 1967 |
[Pathology of therapy and pathomorphosis of some diseases in children].
Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Anti-Bacterial Agents; Antimetabolites; Bone and Bon | 1967 |
Chlorpromazine-induced emphysema. Results of an initial study in the horse.
Topics: Animals; Atrophy; Bronchial Arteries; Bronchial Diseases; Chlorpromazine; Endarteritis; Horses; Inje | 1965 |