Page last updated: 2024-08-07 13:16:20
Phospholipase A2 group V
A phospholipase A2 group V that is encoded in the genome of human. [PRO:DNx, UniProtKB:P39877]
Synonyms
EC 3.1.1.4;
PLA2-10;
Phosphatidylcholine 2-acylhydrolase 5
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| varespladib | Homo sapiens (human) | IC50 | 0.2738 | 5 | 5 |
| ym 26734 | Homo sapiens (human) | IC50 | 0.1100 | 1 | 1 |
| indoxam | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 3-octylthio-1,1,1-trifluoro-2-propanone | Homo sapiens (human) | XI50 | 0.0001 | 1 | 1 |
| varespladib | Homo sapiens (human) | XI50 | 0.0010 | 7 | 7 |
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| calcium-independent phospholipase A2 activity | molecular function | Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+. [EC:3.1.1.4] |
| calcium-dependent phospholipase A2 activity | molecular function | Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+. [EC:3.1.1.4] |
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
| phospholipid binding | molecular function | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732] |
Located In
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| Golgi apparatus | cellular component | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| early phagosome | cellular component | A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis. [GOC:mah, PMID:12388753] |
| phagolysosome | cellular component | A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes. [GOC:mah, PMID:12388753, PMID:14733906] |
| recycling endosome | cellular component | An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044] |
Involved In
This protein is involved in 17 target(s):
| Target | Category | Definition |
|---|---|---|
| fatty acid metabolic process | biological process | The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684] |
| positive regulation of phospholipase activity | biological process | Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. [GOC:BHF, GOC:dph, GOC:tb] |
| positive regulation of macrophage derived foam cell differentiation | biological process | Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:dph, GOC:tb] |
| leukotriene biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. [GOC:go_curators] |
| low-density lipoprotein particle remodeling | biological process | The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] |
| phosphatidylcholine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:jp] |
| cardiolipin acyl-chain remodeling | biological process | Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids. [GOC:bf, GOC:rb, PMID:19244244] |
| positive regulation of phagocytosis | biological process | Any process that activates or increases the frequency, rate or extent of phagocytosis. [GOC:ai] |
| positive regulation of ERK1 and ERK2 cascade | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah] |
| positive regulation of immune complex clearance by monocytes and macrophages | biological process | Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages. [GOC:BHF] |
| phagosome-lysosome fusion | biological process | The creation of a phagolysosome from a phagosome and a lysosome. [GOC:kmv, GOC:tb] |
| positive regulation of opsonization | biological process | Any process that activates or increases the frequency, rate or extent of opsonization. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22333221] |
| positive regulation of antifungal innate immune response | biological process | Any process that activates or increases the frequency, rate or extent of an antifungal innate immune response. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487] |
| positive regulation of phagosome maturation | biological process | Any process that activates or increases the frequency, rate or extent of phagosome maturation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] |
| phospholipid metabolic process | biological process | The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732] |
| negative regulation of T cell proliferation | biological process | Any process that stops, prevents or reduces the rate or extent of T cell proliferation. [GOC:jl] |
| arachidonic acid secretion | biological process | The controlled release of arachidonic acid from a cell or a tissue. [GOC:ai] |