B2 bradykinin receptor

A B2 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30411]

Synonyms

B2R;
BK-2 receptor

Research

Bioassay Publications (23)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	1 (4.35)	18.7374
1990's	7 (30.43)	18.2507
2000's	8 (34.78)	29.6817
2010's	6 (26.09)	24.3611
2020's	1 (4.35)	2.80

Compounds (13)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
amiodarone	Homo sapiens (human)	IC50	12.9660	1	0
amiodarone	Homo sapiens (human)	Ki	7.6740	1	0
arg-3-hyp-7-phe-bradykinin	Homo sapiens (human)	IC50	0.0113	4	4
bradykinin, leu(8)-des-arg(9)-	Homo sapiens (human)	Ki	0.0100	1	1
bradykinin	Homo sapiens (human)	IC50	0.0018	1	1
bradykinin	Homo sapiens (human)	Ki	0.0005	5	5
tamoxifen	Homo sapiens (human)	IC50	20.3560	1	0
tamoxifen	Homo sapiens (human)	Ki	12.0480	1	0
fr 173657	Homo sapiens (human)	IC50	0.0014	3	3
fr 190997	Homo sapiens (human)	IC50	0.0004	3	3
bradyzide	Homo sapiens (human)	Ki	0.7720	1	1
icatibant	Homo sapiens (human)	IC50	0.0019	4	4
icatibant	Homo sapiens (human)	Ki	0.0001	4	4
rmp 7	Homo sapiens (human)	Ki	0.0190	1	1
cp 195543	Homo sapiens (human)	IC50	0.2800	1	1
cp 105696	Homo sapiens (human)	IC50	76.7000	1	1
nitd 609	Homo sapiens (human)	IC50	30.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bradykinin	Homo sapiens (human)	EC50	0.0000	1	1
icatibant	Homo sapiens (human)	Kd	0.0003	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bradykinin	Homo sapiens (human)	ED50	0.0016	1	1
bradykinin	Homo sapiens (human)	pD	8,780,000.0000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
protease binding	molecular function	Binding to a protease or a peptidase. [GOC:hjd]
phosphatidylinositol phospholipase C activity	molecular function	Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+. [EC:3.1.4.11, RHEA:33179]
bradykinin receptor activity	molecular function	Combining with bradykinin to initiate a change in cell activity. [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
type 1 angiotensin receptor binding	molecular function	Binding to a type 1 angiotensin receptor. [GOC:mah, GOC:nln]
protein heterodimerization activity	molecular function	Binding to a nonidentical protein to form a heterodimer. [GOC:ai]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
endosome	cellular component	A vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]
Golgi apparatus	cellular component	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 16 target(s):

Target	Category	Definition
smooth muscle contraction	biological process	A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732]
inflammatory response	biological process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
cell surface receptor signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]
cell surface receptor protein tyrosine kinase signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
blood circulation	biological process	The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. [GOC:mtg_heart, ISBN:0192800825]
response to salt stress	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. [GOC:jl]
regulation of vasoconstriction	biological process	Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. [GOC:jl]
negative regulation of peptidyl-serine phosphorylation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah]
vasoconstriction	biological process	A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure. [GOC:pr, ISBN:0192800752]
vasodilation	biological process	An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure. [GOC:pr, ISBN:0192800981]
regulation of vascular permeability	biological process	Any process that modulates the extent to which blood vessels can be pervaded by fluid. [GOC:jl]
arachidonic acid secretion	biological process	The controlled release of arachidonic acid from a cell or a tissue. [GOC:ai]
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator. [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598]
intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	biological process	The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of osmotic stress, and ends when the execution phase of apoptosis is triggered. [GOC:krc, GOC:mtg_apoptosis, PMID:16571598]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]