Proteins > Histone deacetylase 1
Page last updated: 2024-08-07 17:05:49

Histone deacetylase 1

A histone deacetylase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13547]

Synonyms

HD1;
EC 3.5.1.98

Research

Bioassay Publications (578)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (0.17)18.2507
2000's98 (16.96)29.6817
2010's339 (58.65)24.3611
2020's140 (24.22)2.80

Compounds (109)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gamma-aminobutyric acidHomo sapiens (human)Ki8.190011
butyric acidHomo sapiens (human)IC50158.000022
butyric acidHomo sapiens (human)Ki136.000011
acetohydroxamic acidHomo sapiens (human)IC50625.000022
celecoxibHomo sapiens (human)IC501.411022
ci 994Homo sapiens (human)IC5011.80001828
ci 994Homo sapiens (human)Ki0.083824
clioquinolHomo sapiens (human)IC5071.0857114
valproic acidHomo sapiens (human)IC501,262.601477
valproic acidHomo sapiens (human)Ki564.000011
fluconazoleHomo sapiens (human)IC5040.000011
beta-thujaplicinHomo sapiens (human)Ki2.500011
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamideHomo sapiens (human)IC501.542033
entinostatHomo sapiens (human)IC502.501982101
entinostatHomo sapiens (human)Ki0.306022
4-phenylbutyric acidHomo sapiens (human)IC5064.000011
4-phenylbutyric acidHomo sapiens (human)Ki2.800011
pomiferinHomo sapiens (human)IC501.050011
ppm 18Homo sapiens (human)IC50180.000011
pyroxamideHomo sapiens (human)IC505.100022
pyroxamideHomo sapiens (human)Ki0.002711
suberoyl bis-hydroxamic acidHomo sapiens (human)IC506.310011
suberoyl bis-hydroxamic acidHomo sapiens (human)Ki0.019011
scriptaidHomo sapiens (human)IC500.831866
scriptaidHomo sapiens (human)Ki0.001511
4-phenylbutyric acid, sodium saltHomo sapiens (human)IC50162.000011
4-phenylbutyric acid, sodium saltHomo sapiens (human)Ki6.340011
fenofibrateHomo sapiens (human)IC5075.000011
imatinibHomo sapiens (human)IC50100.000011
vorinostatHomo sapiens (human)IC501.4481498540
vorinostatHomo sapiens (human)Ki0.36521113
benzohydroxamic acidHomo sapiens (human)IC5017.527544
acetylcysteineHomo sapiens (human)IC503,160.000011
camptothecinHomo sapiens (human)IC500.050011
2,3-dihydroxypyridineHomo sapiens (human)IC500.020011
daunorubicinHomo sapiens (human)IC500.047011
lovastatinHomo sapiens (human)IC5011.911011
atorvastatinHomo sapiens (human)IC5011.619011
bendamustineHomo sapiens (human)IC500.010011
nicotinohydroxamic acidHomo sapiens (human)IC5034.958011
ubenimexHomo sapiens (human)IC50400.000033
osajinHomo sapiens (human)IC506.530011
8-mercaptoquinolineHomo sapiens (human)IC50200.000011
zm 241385Homo sapiens (human)IC5010.000011
lapatinibHomo sapiens (human)IC5055.000022
n-hydroxy-2,2-diphenylacetamideHomo sapiens (human)IC5013.325746
bortezomibHomo sapiens (human)IC500.620011
trapoxin aHomo sapiens (human)IC500.003544
actinoninHomo sapiens (human)IC5010.000011
e-z cinnamic acidHomo sapiens (human)Ki0.008211
trichostatin aHomo sapiens (human)IC500.4191114134
trichostatin aHomo sapiens (human)Ki0.072377
caffeic acidHomo sapiens (human)IC502,540.000011
caffeic acidHomo sapiens (human)Ki10.840011
curcuminHomo sapiens (human)IC50187.000011
curcuminHomo sapiens (human)Ki50.790011
chlorogenic acidHomo sapiens (human)IC50258.333333
chlorogenic acidHomo sapiens (human)Ki0.135011
zd 6474Homo sapiens (human)IC5010.000033
desmethylanethol trithioneHomo sapiens (human)IC500.450022
5-chloro-7-[(4-ethyl-1-piperazinyl)-(3-pyridinyl)methyl]-8-quinolinolHomo sapiens (human)IC5025.195018
ex 527Homo sapiens (human)IC50100.000011
sodium butyrateHomo sapiens (human)IC50274.000044
sodium butyrateHomo sapiens (human)Ki365.000011
5'-o-caffeoylquinic acidHomo sapiens (human)IC50185.200022
harmineHomo sapiens (human)IC505.500066
aureusidinHomo sapiens (human)IC5028.250022
romidepsinHomo sapiens (human)IC500.44892021
romidepsinHomo sapiens (human)Ki0.000022
carboxycinnamic acid bishydroxamideHomo sapiens (human)IC500.010011
3',4'-dihydroxyauroneHomo sapiens (human)IC509.800022
psammaplin aHomo sapiens (human)IC500.026844
trichostatin cHomo sapiens (human)IC5023.630011
laq824Homo sapiens (human)IC500.05121421
laq824Homo sapiens (human)Ki0.000622
indigo carmineHomo sapiens (human)IC50321.620022
tanespimycinHomo sapiens (human)IC501,000.000011
pd 404182Homo sapiens (human)IC504.000011
tubacinHomo sapiens (human)IC501.24501010
tubacinHomo sapiens (human)Ki1.464446
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetroneHomo sapiens (human)IC500.02271919
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetroneHomo sapiens (human)Ki0.000011
belinostatHomo sapiens (human)IC503.08322032
belinostatHomo sapiens (human)Ki0.009233
sk-7041Homo sapiens (human)IC500.172011
panobinostatHomo sapiens (human)IC500.18102937
panobinostatHomo sapiens (human)Ki0.001655
hdac-42Homo sapiens (human)IC500.112033
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideHomo sapiens (human)IC505.72661334
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideHomo sapiens (human)Ki0.125524
n1-(2-aminophenyl)-n7-phenylheptanediamideHomo sapiens (human)IC5026.132733
bml 210Homo sapiens (human)IC5045.31001010
n-(2-amino-5-fluorobenzyl)-4-(n-(pyridine-3-acrylyl)aminomethyl)benzamideHomo sapiens (human)IC5022.34831212
givinostatHomo sapiens (human)IC500.079333
givinostatHomo sapiens (human)Ki0.002022
mocetinostatHomo sapiens (human)IC502.48921727
mocetinostatHomo sapiens (human)Ki0.009011
6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-n-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6s)-Homo sapiens (human)IC5010.000011
methyl 3,5-di-o-caffeoyl quinateHomo sapiens (human)IC506.290022
r 306465Homo sapiens (human)IC500.004222
luotonin aHomo sapiens (human)IC506.400011
di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazoneHomo sapiens (human)IC505.000011
spiruchostatin aHomo sapiens (human)IC500.003311
nutlin-3aHomo sapiens (human)IC50100.000011
psoralenosideHomo sapiens (human)IC504.600011
quisinostatHomo sapiens (human)IC500.000999
quisinostatHomo sapiens (human)Ki0.002633
resminostatHomo sapiens (human)IC500.460022
abexinostatHomo sapiens (human)IC500.021011
abexinostatHomo sapiens (human)Ki0.046538
chidamideHomo sapiens (human)IC500.8760109
hc toxinHomo sapiens (human)IC500.430011
hc toxinHomo sapiens (human)Ki0.190011
azumamide eHomo sapiens (human)IC500.635022
azumamide eHomo sapiens (human)Ki0.067011
cnf 2024Homo sapiens (human)IC501.000022
N-(2-aminophenyl)-2-pyrazinecarboxamideHomo sapiens (human)IC502.151022
pci 34051Homo sapiens (human)IC5029.57741212
cudc 101Homo sapiens (human)IC500.155474
largazoleHomo sapiens (human)IC500.31111010
N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl esterHomo sapiens (human)IC500.643477
trichostatin rkHomo sapiens (human)IC50100.000011
jq1 compoundHomo sapiens (human)IC500.291011
tubastatin aHomo sapiens (human)IC5010.28535362
tubastatin aHomo sapiens (human)Ki2.551622
pracinostatHomo sapiens (human)IC500.088022
pracinostatHomo sapiens (human)Ki0.028011
acy-1215Homo sapiens (human)IC500.08612222
acy-1215Homo sapiens (human)Ki0.074011
cudc-907Homo sapiens (human)IC500.002299
rgfp966Homo sapiens (human)IC507.200033
rg2833Homo sapiens (human)IC500.300011
rg2833Homo sapiens (human)Ki0.032011
mi-192Homo sapiens (human)IC504.800011
acy-738Homo sapiens (human)IC500.094033
2-((1-(3-fluorophenyl)cyclohexyl)amino)-n-hydroxypyrimidine-5-carboxamideHomo sapiens (human)IC502.123022
4-((1-butyl-3-phenylureido)methyl)-n-hydroxybenzamideHomo sapiens (human)IC501.50971111
osimertinibHomo sapiens (human)IC501.000011
santacruzamate aHomo sapiens (human)IC505.000011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
bufexamacHomo sapiens (human)Kd1,000.000011
ci 994Homo sapiens (human)EC503.810011
entinostatHomo sapiens (human)EC501.000022
entinostatHomo sapiens (human)Kd0.219012
imatinibHomo sapiens (human)EC50100.000011
vorinostatHomo sapiens (human)EC502.819788
vorinostatHomo sapiens (human)Kd0.128323
trichostatin aHomo sapiens (human)EC503.500022
trichostatin aHomo sapiens (human)Kd0.013712
romidepsinHomo sapiens (human)EC5036.000011
tubacinHomo sapiens (human)EC50217.000011
belinostatHomo sapiens (human)EC500.035522
panobinostatHomo sapiens (human)EC500.169511
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideHomo sapiens (human)Kd0.046612
kd 5170Homo sapiens (human)EC500.045011
cudc-907Homo sapiens (human)EC500.126211

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamideHomo sapiens (human)AC502.100011
pyroxamideHomo sapiens (human)AC507.900011
vorinostatHomo sapiens (human)AC503.100011
vorinostatHomo sapiens (human)INH0.188522
vorinostatHomo sapiens (human)Inhibition0.080011
trapoxin aHomo sapiens (human)AC500.010011
trichostatin aHomo sapiens (human)AC500.400011
trichostatin aHomo sapiens (human)Inhibition0.003511
romidepsinHomo sapiens (human)INH0.024411
laq824Homo sapiens (human)Occ500.006011
largazoleHomo sapiens (human)INH0.572011

Enables

This protein enables 18 target(s):

TargetCategoryDefinition
RNA polymerase II cis-regulatory region sequence-specific DNA bindingmolecular functionBinding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]
RNA polymerase II core promoter sequence-specific DNA bindingmolecular functionBinding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene. [GOC:pg, GOC:txnOH, PMID:12381658]
core promoter sequence-specific DNA bindingmolecular functionBinding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. [GOC:pg, GOC:txnOH]
transcription corepressor bindingmolecular functionBinding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. [GOC:krc]
p53 bindingmolecular functionBinding to one of the p53 family of proteins. [GOC:hjd]
transcription corepressor activitymolecular functionA transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
histone deacetylase activitymolecular functionCatalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. [PMID:9893272, RHEA:58196]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
enzyme bindingmolecular functionBinding to an enzyme, a protein with catalytic activity. [GOC:jl]
protein lysine deacetylase activitymolecular functionCatalysis of the reaction: H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]. [PMID:27296530, RHEA:58108]
Krueppel-associated box domain bindingmolecular functionBinding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors. [InterPro:IPR001909]
histone deacetylase bindingmolecular functionBinding to histone deacetylase. [GOC:jl]
NF-kappaB bindingmolecular functionBinding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. [GOC:ai]
RNA polymerase II-specific DNA-binding transcription factor bindingmolecular functionBinding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. [GOC:dph, GOC:vw]
E-box bindingmolecular functionBinding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. [GOC:BHF, GOC:vk, PMID:11812799]
DNA-binding transcription factor bindingmolecular functionBinding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. [GOC:txnOH-2018]
histone decrotonylase activitymolecular functionCatalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] = (2E)-2-butenoate + L-lysyl-[histone]. [PMID:28497810]
promoter-specific chromatin bindingmolecular functionBinding to a section of chromatin that is associated with gene promoter sequences of DNA. [PMID:19948729]

Located In

This protein is located in 5 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
neuronal cell bodycellular componentThe portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 7 target(s):

TargetCategoryDefinition
NuRD complexcellular componentAn approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins. [PMID:10589671, PMID:11743021, PMID:17289569]
Sin3-type complexcellular componentAny of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. [PMID:15565322, PMID:18292778]
histone deacetylase complexcellular componentA protein complex that possesses histone deacetylase activity. [GOC:mah]
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]
heterochromatincellular componentA compact and highly condensed form of chromatin that is refractory to transcription. [PMID:32017156]
transcription repressor complexcellular componentA protein complex that possesses activity that prevents or downregulates transcription. [GOC:mah]
protein-containing complexcellular componentA stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]

Involved In

This protein is involved in 40 target(s):

TargetCategoryDefinition
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
chromatin organizationbiological processThe assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. [PMID:20404130]
chromatin remodelingbiological processA dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
DNA methylation-dependent heterochromatin formationbiological processRepression of transcription by methylation of DNA, leading to the formation of heterochromatin. [GOC:mah]
regulation of transcription by RNA polymerase IIbiological processAny process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
protein deacetylationbiological processThe removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:ai]
endoderm developmentbiological processThe process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. [GOC:dph, GOC:tb]
positive regulation of cell population proliferationbiological processAny process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
epidermal cell differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]
positive regulation of gene expressionbiological processAny process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
negative regulation of gene expressionbiological processAny process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
hippocampus developmentbiological processThe progression of the hippocampus over time from its initial formation until its mature state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420, UBERON:0002421]
neuron differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of a neuron. [GOC:mah]
negative regulation of cell migrationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cell migration. [GOC:go_curators]
negative regulation of transforming growth factor beta receptor signaling pathwaybiological processAny process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. [GOC:mah]
circadian regulation of gene expressionbiological processAny process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. [GOC:mah]
cellular response to platelet-derived growth factor stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. [GOC:yaf]
odontogenesis of dentin-containing toothbiological processThe process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. [GOC:cjm, GOC:mah, GOC:mtg_sensu, PMID:10333884, PMID:15355794]
regulation of cell fate specificationbiological processAny process that mediates the adoption of a specific fate by a cell. [GOC:go_curators]
embryonic digit morphogenesisbiological processThe process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. [GOC:bf, GOC:jl, UBERON:0002544]
negative regulation of apoptotic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of canonical NF-kappaB signal transductionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
negative regulation by host of viral transcriptionbiological processAny process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription. [GOC:jl]
negative regulation of gene expression, epigeneticbiological processAn epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation. [PMID:22243696]
negative regulation of DNA-templated transcriptionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of DNA-templated transcriptionbiological processAny process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
positive regulation of smooth muscle cell proliferationbiological processAny process that activates or increases the rate or extent of smooth muscle cell proliferation. [CL:0000192, GOC:ebc]
oligodendrocyte differentiationbiological processThe process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. [GOC:vp, PMID:15139015]
positive regulation of oligodendrocyte differentiationbiological processAny process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation. [GOC:vp, PMID:15139015]
negative regulation of androgen receptor signaling pathwaybiological processAny process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway. [GOC:dph]
hair follicle placode formationbiological processThe developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud. [GOC:dph, GOC:sdb_2009, GOC:tb]
eyelid development in camera-type eyebiological processThe progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye. [GOC:dph, GOC:yaf]
fungiform papilla formationbiological processThe developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue. [GOC:dph]
negative regulation of canonical Wnt signaling pathwaybiological processAny process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:dph, GOC:tb]
negative regulation of stem cell population maintenancebiological processAny process that stops, prevents or reduces the frequency, rate or extent of stem cell population maintenance. [GOC:hjd, GOC:TermGenie, PMID:22969033]
positive regulation of stem cell population maintenancebiological processAny process that activates or increases the frequency, rate or extent of stem cell population maintenance. [GOC:hjd, GOC:TermGenie, PMID:22969033]
regulation of stem cell differentiationbiological processAny process that modulates the frequency, rate or extent of stem cell differentiation. [GOC:obol]
negative regulation of intrinsic apoptotic signaling pathwaybiological processAny process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]
heterochromatin formationbiological processAn epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. [PMID:25192661, PMID:33827924]