Proteins > Phosphoribosyl pyrophosphate synthase-associated protein 2
Page last updated: 2024-08-07 19:25:30
Phosphoribosyl pyrophosphate synthase-associated protein 2
A phosphoribosyl pyrophosphate synthase-associated protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60256]
Synonyms
PRPP synthase-associated protein 2;
41 kDa phosphoribosypyrophosphate synthetase-associated protein;
PAP41
Research
Bioassay Publications (1)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (1)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| adefovir | Homo sapiens (human) | Ki | 3,000.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| adefovir | Homo sapiens (human) | Km | 1,500.0000 | 1 | 1 |
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|
| magnesium ion binding | molecular function | Binding to a magnesium (Mg) ion. [GOC:ai] |
| enzyme inhibitor activity | molecular function | Binds to and stops, prevents or reduces the activity of an enzyme. [GOC:ai, GOC:ebc] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| ribose phosphate diphosphokinase activity | molecular function | Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+. [EC:2.7.6.1, RHEA:15609] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| ribose phosphate diphosphokinase complex | cellular component | A protein complex having ribose phosphate diphosphokinase activity. [GO:hjd, PMID:9348095] |
Involved In
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|
| nucleobase-containing compound metabolic process | biological process | Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:ai] |
| bone development | biological process | The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. [GOC:dph] |
| 5-phosphoribose 1-diphosphate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate. [GOC:ai] |
| purine nucleotide biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732] |