celecoxib has been researched along with Necrosis in 13 studies
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report in this study that a clinically available COX-2 inhibitor, celecoxib, exacerbates porcine serum (PS)-induced hepatic fibrosis and induces hepatocellular necrosis in an experimental liver fibrosis model." | 7.75 | Celecoxib exacerbates hepatic fibrosis and induces hepatocellular necrosis in rats treated with porcine serum. ( Li, X; Liu, H; Wei, W, 2009) |
| "Toward improved glioblastoma multiforme treatment, we determined whether celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, could enhance glioblastoma radiosensitivity by inducing tumor necrosis and inhibiting tumor angiogenesis." | 7.74 | Enhancement of glioblastoma radioresponse by a selective COX-2 inhibitor celecoxib: inhibition of tumor angiogenesis with extensive tumor necrosis. ( Cheah, ES; Kang, KB; Moore, XL; Wang, TT; Wong, MC; Woon, CT; Zhu, C, 2007) |
| "Celecoxib and citrate have been shown to possess antitumor activity in a variety of cancer cells." | 5.42 | Citrate and celecoxib induce apoptosis and decrease necrosis in synergistic manner in canine mammary tumor cells. ( Farsinejad, A; Panahi, N; Safi, S; Vahidi, R, 2015) |
| " We recently showed that NSAIDs such as indomethacin and celecoxib have direct cytotoxicity (ability to induce necrosis and apoptosis in gastric mucosal cells) due to their membrane permeabilizing activities, which is involved in NSAID-induced gastric lesions." | 3.76 | Low direct cytotoxicity of loxoprofen on gastric mucosal cells. ( Arai, Y; Ishihara, T; Kimoto, A; Mizushima, T; Okamoto, Y; Otsuka, M; Suemasu, S; Tanaka, K; Yamakawa, N; Yokomizo, K, 2010) |
| " We report in this study that a clinically available COX-2 inhibitor, celecoxib, exacerbates porcine serum (PS)-induced hepatic fibrosis and induces hepatocellular necrosis in an experimental liver fibrosis model." | 3.75 | Celecoxib exacerbates hepatic fibrosis and induces hepatocellular necrosis in rats treated with porcine serum. ( Li, X; Liu, H; Wei, W, 2009) |
| "Toward improved glioblastoma multiforme treatment, we determined whether celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, could enhance glioblastoma radiosensitivity by inducing tumor necrosis and inhibiting tumor angiogenesis." | 3.74 | Enhancement of glioblastoma radioresponse by a selective COX-2 inhibitor celecoxib: inhibition of tumor angiogenesis with extensive tumor necrosis. ( Cheah, ES; Kang, KB; Moore, XL; Wang, TT; Wong, MC; Woon, CT; Zhu, C, 2007) |
| "In 5 random groups of Wistar rats (n = 15 for each group), ulcerogenic doses of NSAIDs COX-1-COX-2 inhibitors such as indomethacin were compared with Celecoxib (COX-2 inhibitor); the production of antrum gastric ulcers and bowel and colon necrotic areas was studied." | 3.70 | [Celecoxib vs indomethacin and acute gastric lesions in rats]. ( Aramberry, LJ; Cesolari, JA; Esnarriaga, JM; Laudanno, OM; Maglione, CB; Piombo, G; Rista, L; Sambrano, JS, 2000) |
| "Celecoxib was tested in combination with imatinib, demonstrating that celecoxib could strengthen the cytotoxicity of imatinib in imatinib-resistant CML cells." | 1.43 | Celecoxib suppresses autophagy and enhances cytotoxicity of imatinib in imatinib-resistant chronic myeloid leukemia cells. ( Deng, XB; Fang, ZG; Lin, DJ; Liu, LL; Liu, Q; Liu, SS; Long, ZJ; Lu, Y; Zou, Y, 2016) |
| "Celecoxib and citrate have been shown to possess antitumor activity in a variety of cancer cells." | 1.42 | Citrate and celecoxib induce apoptosis and decrease necrosis in synergistic manner in canine mammary tumor cells. ( Farsinejad, A; Panahi, N; Safi, S; Vahidi, R, 2015) |
| "A new non-cytotoxic therapy that SOM230 (pasireotide)，a somatostatin analogue (SSTA) combined with celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor was tested in nude mice bearing HepG2 xenografts." | 1.37 | SOM230 combined with celecoxib prolongs the survival in nude mice with HepG-2 xenografts. ( Chen, S; Tang, CW; Wang, CH; Xie, Y, 2011) |
| " However, the tumors administered with a initial dose of CX at 24-h post-PDT had no tumor control." | 1.33 | Anti-angiogenic effects of Hypericin-photodynamic therapy in combination with Celebrex in the treatment of human nasopharyngeal carcinoma. ( Olivo, M; Soo, KC; Yee, KK, 2005) |
| "Colitis was induced by intracolonic administration of trinitrobenzene sulfonic acid." | 1.31 | Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis. ( Ajuebor, MN; Singh, A; Wallace, JL, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (46.15) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uram, Ł | 1 |
| Misiorek, M | 1 |
| Pichla, M | 1 |
| Filipowicz-Rachwał, A | 1 |
| Markowicz, J | 1 |
| Wołowiec, S | 1 |
| Wałajtys-Rode, E | 1 |
| Vahidi, R | 1 |
| Safi, S | 1 |
| Farsinejad, A | 1 |
| Panahi, N | 1 |
| Lu, Y | 2 |
| Liu, LL | 2 |
| Liu, SS | 1 |
| Fang, ZG | 1 |
| Zou, Y | 1 |
| Deng, XB | 1 |
| Long, ZJ | 1 |
| Liu, Q | 1 |
| Lin, DJ | 1 |
| Liu, XF | 1 |
| Liu, TR | 1 |
| Fan, RF | 1 |
| Xu, YC | 1 |
| Zhang, XZ | 1 |
| Liu, H | 1 |
| Wei, W | 1 |
| Li, X | 1 |
| Yamakawa, N | 1 |
| Suemasu, S | 1 |
| Kimoto, A | 1 |
| Arai, Y | 1 |
| Ishihara, T | 1 |
| Yokomizo, K | 1 |
| Okamoto, Y | 1 |
| Otsuka, M | 1 |
| Tanaka, K | 1 |
| Mizushima, T | 1 |
| Washino, Y | 1 |
| Koga, E | 1 |
| Kitamura, Y | 1 |
| Kamikawa, C | 1 |
| Kobayashi, K | 1 |
| Nakagawa, T | 1 |
| Nakazaki, C | 1 |
| Ichi, I | 1 |
| Kojo, S | 1 |
| Xie, Y | 1 |
| Chen, S | 1 |
| Wang, CH | 1 |
| Tang, CW | 1 |
| Kang, KB | 2 |
| Wang, TT | 2 |
| Woon, CT | 2 |
| Cheah, ST | 1 |
| Lim, YK | 1 |
| Moore, XL | 2 |
| Wong, MC | 2 |
| Yee, KK | 1 |
| Soo, KC | 1 |
| Olivo, M | 1 |
| Cheah, ES | 1 |
| Zhu, C | 1 |
| Ajuebor, MN | 1 |
| Singh, A | 1 |
| Wallace, JL | 1 |
| Laudanno, OM | 1 |
| Esnarriaga, JM | 1 |
| Cesolari, JA | 1 |
| Maglione, CB | 1 |
| Aramberry, LJ | 1 |
| Sambrano, JS | 1 |
| Piombo, G | 1 |
| Rista, L | 1 |
13 other studies available for celecoxib and Necrosis
| Article | Year |
|---|---|
The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPARγ Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro.
Topics: Antineoplastic Agents; Apoptosis; Biotinylation; Celecoxib; Cell Line, Tumor; Cell Movement; Cell Pr | 2019 |
Citrate and celecoxib induce apoptosis and decrease necrosis in synergistic manner in canine mammary tumor cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Celecoxib; Cell Line, Tumor; Cell Proliferation; Cell Sur | 2015 |
Celecoxib suppresses autophagy and enhances cytotoxicity of imatinib in imatinib-resistant chronic myeloid leukemia cells.
Topics: Adult; Apoptosis; Autophagy; Celecoxib; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; G1 Phas | 2016 |
Celecoxib exerts antitumor effects in HL-60 acute leukemia cells and inhibits autophagy by affecting lysosome function.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Celecoxib; Cell Proliferation; Chloroquine; HL-60 Cells | 2016 |
Celecoxib exacerbates hepatic fibrosis and induces hepatocellular necrosis in rats treated with porcine serum.
Topics: Animals; Body Weight; Celecoxib; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2 Inhibitors | 2009 |
Low direct cytotoxicity of loxoprofen on gastric mucosal cells.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; | 2010 |
Effect of celecoxib, a selective cyclooxygenase-2 inhibitor on carbon tetrachloride intoxication in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; Carbon Tetr | 2010 |
SOM230 combined with celecoxib prolongs the survival in nude mice with HepG-2 xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Celec | 2011 |
Celecoxib enhances brain tumour cell radiosensitivity leading to massive tumour necrosis.
Topics: Angiopoietin-1; Angiopoietin-2; Animals; Brain Neoplasms; Celecoxib; Cell Survival; Cyclooxygenase I | 2004 |
Anti-angiogenic effects of Hypericin-photodynamic therapy in combination with Celebrex in the treatment of human nasopharyngeal carcinoma.
Topics: Angiogenesis Inhibitors; Animals; Anthracenes; Celecoxib; Cyclooxygenase 2; Drug Therapy, Combinatio | 2005 |
Enhancement of glioblastoma radioresponse by a selective COX-2 inhibitor celecoxib: inhibition of tumor angiogenesis with extensive tumor necrosis.
Topics: Angiopoietin-1; Angiopoietin-2; Animals; Brain Neoplasms; Celecoxib; Cell Line, Tumor; Combined Moda | 2007 |
Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis.
Topics: Animals; Blotting, Western; Celecoxib; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclo | 2000 |
[Celecoxib vs indomethacin and acute gastric lesions in rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Digestive Sy | 2000 |