Page last updated: 2024-10-24

celecoxib and Necrosis

celecoxib has been researched along with Necrosis in 13 studies

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
" We report in this study that a clinically available COX-2 inhibitor, celecoxib, exacerbates porcine serum (PS)-induced hepatic fibrosis and induces hepatocellular necrosis in an experimental liver fibrosis model."7.75Celecoxib exacerbates hepatic fibrosis and induces hepatocellular necrosis in rats treated with porcine serum. ( Li, X; Liu, H; Wei, W, 2009)
"Toward improved glioblastoma multiforme treatment, we determined whether celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, could enhance glioblastoma radiosensitivity by inducing tumor necrosis and inhibiting tumor angiogenesis."7.74Enhancement of glioblastoma radioresponse by a selective COX-2 inhibitor celecoxib: inhibition of tumor angiogenesis with extensive tumor necrosis. ( Cheah, ES; Kang, KB; Moore, XL; Wang, TT; Wong, MC; Woon, CT; Zhu, C, 2007)
"Celecoxib and citrate have been shown to possess antitumor activity in a variety of cancer cells."5.42Citrate and celecoxib induce apoptosis and decrease necrosis in synergistic manner in canine mammary tumor cells. ( Farsinejad, A; Panahi, N; Safi, S; Vahidi, R, 2015)
" We recently showed that NSAIDs such as indomethacin and celecoxib have direct cytotoxicity (ability to induce necrosis and apoptosis in gastric mucosal cells) due to their membrane permeabilizing activities, which is involved in NSAID-induced gastric lesions."3.76Low direct cytotoxicity of loxoprofen on gastric mucosal cells. ( Arai, Y; Ishihara, T; Kimoto, A; Mizushima, T; Okamoto, Y; Otsuka, M; Suemasu, S; Tanaka, K; Yamakawa, N; Yokomizo, K, 2010)
" We report in this study that a clinically available COX-2 inhibitor, celecoxib, exacerbates porcine serum (PS)-induced hepatic fibrosis and induces hepatocellular necrosis in an experimental liver fibrosis model."3.75Celecoxib exacerbates hepatic fibrosis and induces hepatocellular necrosis in rats treated with porcine serum. ( Li, X; Liu, H; Wei, W, 2009)
"Toward improved glioblastoma multiforme treatment, we determined whether celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, could enhance glioblastoma radiosensitivity by inducing tumor necrosis and inhibiting tumor angiogenesis."3.74Enhancement of glioblastoma radioresponse by a selective COX-2 inhibitor celecoxib: inhibition of tumor angiogenesis with extensive tumor necrosis. ( Cheah, ES; Kang, KB; Moore, XL; Wang, TT; Wong, MC; Woon, CT; Zhu, C, 2007)
"In 5 random groups of Wistar rats (n = 15 for each group), ulcerogenic doses of NSAIDs COX-1-COX-2 inhibitors such as indomethacin were compared with Celecoxib (COX-2 inhibitor); the production of antrum gastric ulcers and bowel and colon necrotic areas was studied."3.70[Celecoxib vs indomethacin and acute gastric lesions in rats]. ( Aramberry, LJ; Cesolari, JA; Esnarriaga, JM; Laudanno, OM; Maglione, CB; Piombo, G; Rista, L; Sambrano, JS, 2000)
"Celecoxib was tested in combination with imatinib, demonstrating that celecoxib could strengthen the cytotoxicity of imatinib in imatinib-resistant CML cells."1.43Celecoxib suppresses autophagy and enhances cytotoxicity of imatinib in imatinib-resistant chronic myeloid leukemia cells. ( Deng, XB; Fang, ZG; Lin, DJ; Liu, LL; Liu, Q; Liu, SS; Long, ZJ; Lu, Y; Zou, Y, 2016)
"Celecoxib and citrate have been shown to possess antitumor activity in a variety of cancer cells."1.42Citrate and celecoxib induce apoptosis and decrease necrosis in synergistic manner in canine mammary tumor cells. ( Farsinejad, A; Panahi, N; Safi, S; Vahidi, R, 2015)
"A new non-cytotoxic therapy that SOM230 (pasireotide),a somatostatin analogue (SSTA) combined with celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor was tested in nude mice bearing HepG2 xenografts."1.37SOM230 combined with celecoxib prolongs the survival in nude mice with HepG-2 xenografts. ( Chen, S; Tang, CW; Wang, CH; Xie, Y, 2011)
" However, the tumors administered with a initial dose of CX at 24-h post-PDT had no tumor control."1.33Anti-angiogenic effects of Hypericin-photodynamic therapy in combination with Celebrex in the treatment of human nasopharyngeal carcinoma. ( Olivo, M; Soo, KC; Yee, KK, 2005)
"Colitis was induced by intracolonic administration of trinitrobenzene sulfonic acid."1.31Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis. ( Ajuebor, MN; Singh, A; Wallace, JL, 2000)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (46.15)29.6817
2010's7 (53.85)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Uram, Ł1
Misiorek, M1
Pichla, M1
Filipowicz-Rachwał, A1
Markowicz, J1
Wołowiec, S1
Wałajtys-Rode, E1
Vahidi, R1
Safi, S1
Farsinejad, A1
Panahi, N1
Lu, Y2
Liu, LL2
Liu, SS1
Fang, ZG1
Zou, Y1
Deng, XB1
Long, ZJ1
Liu, Q1
Lin, DJ1
Liu, XF1
Liu, TR1
Fan, RF1
Xu, YC1
Zhang, XZ1
Liu, H1
Wei, W1
Li, X1
Yamakawa, N1
Suemasu, S1
Kimoto, A1
Arai, Y1
Ishihara, T1
Yokomizo, K1
Okamoto, Y1
Otsuka, M1
Tanaka, K1
Mizushima, T1
Washino, Y1
Koga, E1
Kitamura, Y1
Kamikawa, C1
Kobayashi, K1
Nakagawa, T1
Nakazaki, C1
Ichi, I1
Kojo, S1
Xie, Y1
Chen, S1
Wang, CH1
Tang, CW1
Kang, KB2
Wang, TT2
Woon, CT2
Cheah, ST1
Lim, YK1
Moore, XL2
Wong, MC2
Yee, KK1
Soo, KC1
Olivo, M1
Cheah, ES1
Zhu, C1
Ajuebor, MN1
Singh, A1
Wallace, JL1
Laudanno, OM1
Esnarriaga, JM1
Cesolari, JA1
Maglione, CB1
Aramberry, LJ1
Sambrano, JS1
Piombo, G1
Rista, L1

Other Studies

13 other studies available for celecoxib and Necrosis

ArticleYear
The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPARγ Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro.
    Molecules (Basel, Switzerland), 2019, Oct-22, Volume: 24, Issue:20

    Topics: Antineoplastic Agents; Apoptosis; Biotinylation; Celecoxib; Cell Line, Tumor; Cell Movement; Cell Pr

2019
Citrate and celecoxib induce apoptosis and decrease necrosis in synergistic manner in canine mammary tumor cells.
    Cellular and molecular biology (Noisy-le-Grand, France), 2015, Oct-16, Volume: 61, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Celecoxib; Cell Line, Tumor; Cell Proliferation; Cell Sur

2015
Celecoxib suppresses autophagy and enhances cytotoxicity of imatinib in imatinib-resistant chronic myeloid leukemia cells.
    Journal of translational medicine, 2016, 09-20, Volume: 14

    Topics: Adult; Apoptosis; Autophagy; Celecoxib; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; G1 Phas

2016
Celecoxib exerts antitumor effects in HL-60 acute leukemia cells and inhibits autophagy by affecting lysosome function.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 84

    Topics: Antineoplastic Agents; Apoptosis; Autophagy; Celecoxib; Cell Proliferation; Chloroquine; HL-60 Cells

2016
Celecoxib exacerbates hepatic fibrosis and induces hepatocellular necrosis in rats treated with porcine serum.
    Prostaglandins & other lipid mediators, 2009, Volume: 88, Issue:3-4

    Topics: Animals; Body Weight; Celecoxib; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2 Inhibitors

2009
Low direct cytotoxicity of loxoprofen on gastric mucosal cells.
    Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:3

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis;

2010
Effect of celecoxib, a selective cyclooxygenase-2 inhibitor on carbon tetrachloride intoxication in rats.
    Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:4

    Topics: Alanine Transaminase; Animals; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; Carbon Tetr

2010
SOM230 combined with celecoxib prolongs the survival in nude mice with HepG-2 xenografts.
    Cancer biology & therapy, 2011, Jul-01, Volume: 12, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Celec

2011
Celecoxib enhances brain tumour cell radiosensitivity leading to massive tumour necrosis.
    Annals of the Academy of Medicine, Singapore, 2004, Volume: 33, Issue:5 Suppl

    Topics: Angiopoietin-1; Angiopoietin-2; Animals; Brain Neoplasms; Celecoxib; Cell Survival; Cyclooxygenase I

2004
Anti-angiogenic effects of Hypericin-photodynamic therapy in combination with Celebrex in the treatment of human nasopharyngeal carcinoma.
    International journal of molecular medicine, 2005, Volume: 16, Issue:6

    Topics: Angiogenesis Inhibitors; Animals; Anthracenes; Celecoxib; Cyclooxygenase 2; Drug Therapy, Combinatio

2005
Enhancement of glioblastoma radioresponse by a selective COX-2 inhibitor celecoxib: inhibition of tumor angiogenesis with extensive tumor necrosis.
    International journal of radiation oncology, biology, physics, 2007, Mar-01, Volume: 67, Issue:3

    Topics: Angiopoietin-1; Angiopoietin-2; Animals; Brain Neoplasms; Celecoxib; Cell Line, Tumor; Combined Moda

2007
Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis.
    American journal of physiology. Gastrointestinal and liver physiology, 2000, Volume: 279, Issue:1

    Topics: Animals; Blotting, Western; Celecoxib; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclo

2000
[Celecoxib vs indomethacin and acute gastric lesions in rats].
    Medicina, 2000, Volume: 60, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Digestive Sy

2000