Page last updated: 2024-09-21

calcium gluconate

Cross-References

ID SourceID
PubMed CID9290
CHEMBL ID2106119
CHEBI ID3309
SCHEMBL ID24132
MeSH IDM0003171

Synonyms (92)

Synonym
d-gluconic acid, calcium salt (2:1)
calciofon
calcium hexagluconate
calglucol
calcipur
einecs 206-075-8
glucobiogen
gluconato di calcio [italian]
calcium gluconate [usan:jan]
kalpren
ccris 1336
hsdb 994
gluconic acid, calcium salt (2:1), d-
calcicol
calcium d-gluconate (1:2)
gluconic acid, calcium salt
ebucin
novocal
dragocal
calglucon
gluconate de calcium [french]
calcium d-gluconate
C08133
299-28-5
calcium gluconate ,
calcium gluconate (usp)
D00935
gluconic acid, calcium salt, d-
calcium bis(d-gluconate)
nsc-744619
G0037
gluconic acid calcium salt
gluconate, calcium
calcii gluconas
ins no.578
calcarea gluconica
e-578
calcium gluconate anhydrous
calcium gluconate hydrate
CHEMBL2106119
calcium di-gluconate
ins-578
calcium gluconate, anhydrous
unii-sqe6vb453k
nsc 744619
gluconate de calcium
sqe6vb453k ,
gluconato di calcio
calcium gluconate [who-dd]
calcium gluconate [fcc]
calcium gluconate anhydrous [usp-rs]
calcium gluconate [vandf]
calcium gluconate [usp impurity]
calcium gluconate [mi]
calcium gluconate, anhydrous [ep monograph]
calcium gluconate [inci]
calcium gluconate [who-ip]
calcium gluconate [orange book]
calcium gluconate [usp monograph]
calcium gluconate [hsdb]
calcii gluconas [who-ip latin]
AKOS015895893
NEEHYRZPVYRGPP-IYEMJOQQSA-L
SCHEMBL24132
CHEBI:3309 ,
W-202243
gluconate calcium
mfcd00064209
2,3,4,5,6-pentahydroxycaproic acid hemicalcium salt
DTXSID2029618 ,
gluconic acid hemicalcium salt
DB11126
calcium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate
Q413739
A876351
F85235
AS-80559
Z2768168188
calgonate calcium gluconate gel2.5%
calcium bis((2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate)
sykes calcium gluconate 23%
dtxcid609618
calcio gluconato
calcium gluconate anhydrous (usp-rs)
calcium gluconate, anhydrous (ep monograph)
calcium di(d-gluconate)
calcium gluconate 23% solution
23% calcium gluconate
calcium glyconate
calgonate calcium gluconate gel
calcium gluconate (usp monograph)
calcium gluconate (usp impurity)

Research Excerpts

Overview

ExcerptReference
"Calcium gluconate extravasation is a process, which, while not common, occurs more frequently in neonatal intensive care units. "( de Toro Santos, FJ; Midón Míguez, J; Pacheco Compaña, FJ, 2017)
"Calcium gluconate extravasation is a process, which, although infrequent, is associated with serious skin and soft-tissue lesions, mainly affecting infants. "( de Toro Santos, FJ; Midón Míguez, J; Pacheco Compaña, FJ, 2017)
"Calcium gluconate extravasation is a process that can cause serious lesions, such as necrosis and calcification of the soft tissues. "( Centeno Cortés, A; de Toro Santos, FJ; López San Martín, P; Midón Míguez, J; Mosquera Osés, JJ; Pacheco Compaña, FJ; Yebra-Pimentel Vidal, MT, 2018)
"Calcium gluconate is a highly sensitive and specific alternative secretagogue to secretin for localisation of pancreatic and duodenal gastrinomas. "( Jackson, JE; Meeran, K; Thakker, RV; Turner, JJ; Wren, AM, 2002)

Treatment

ExcerptReference
"Calcium gluconate treatment is not effective in the prevention of OHSS."( Karakus, C; Ozyurt, R; Turktekin, N, 2022)
"Calcium gluconate treatments increased milk fat concentration, and a tendency was observed for increased milk fat yield and energy-corrected milk yield above levels achieved by CON, with maximal treatment responses of 4.43% (CON 3.81%), 2.089 kg/d (CON 1.760 kg/d), and 51.8 kg/d (CON 47.1 kg/d), respectively."( Carson, M; Doelman, J; McKnight, LL; Metcalf, JA; Nichols, K; Waterman, DF, 2019)
"calcium gluconate for treatment of hypocalcemia."( Adamski, J; Eisenmann, C; Griffin, AC; Milone, MC; Sachais, BS, 2010)
"Post-treatment with calcium gluconate inhibited LPS-induced airway inflammatory injury and the release of inflammatory cytokines."( Dai, L; Liu, F; Liu, L; Liu, P; Wen, F; Xu, D; Yan, H, 2018)
"Treatment with calcium gluconate before exposure to 4000 ppm SO2F2 for 45 min resulted in 80% survival."( Albee, RR; Mattsson, JL; Miller, RR; Nitschke, KD, 1986)

Roles (1)

RoleDescription
nutraceuticalA product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
calcium salt
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (1,052)

TimeframeStudies, This Drug (%)All Drugs %
pre-1990355 (33.75)18.7374
1990's196 (18.63)18.2507
2000's223 (21.20)29.6817
2010's230 (21.86)24.3611
2020's48 (4.56)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials76 (6.50%)5.53%
Reviews66 (5.65%)6.00%
Case Studies349 (29.85%)4.05%
Observational2 (0.17%)0.25%
Other676 (57.83%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research Highlights

Safety/Toxicity (27)

ArticleYear
Analysis of Factors Contributing to the Occurrence of Systemic Toxicity in Patients with Hydrofluoric Acid Skin Exposure Injury: An Individual Participant Data Meta-Analysis of 125 Clinical Cases from 1979 to 2020.
Journal of burn care & research : official publication of the American Burn Association, 03-02, Volume: 44, Issue: 2
2023
Effectiveness of supplemental oral calcium drink in preventing citrate-related adverse effects in peripheral blood progenitor cell collection.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, Volume: 60, Issue: 4
2021
Infant Parenteral Nutrition Remains a Significant Source for Aluminum Toxicity.
JPEN. Journal of parenteral and enteral nutrition, Volume: 41, Issue: 7
2017
Prophylactic low dose continuous calcium infusion during peripheral blood stem cell (PBSC) collections to reduce citrate related toxicity.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, Volume: 54, Issue: 3
2016
Refining calcium test for the diagnosis of medullary thyroid cancer: cutoffs, procedures, and safety.
The Journal of clinical endocrinology and metabolism, Volume: 99, Issue: 5
2014
Safety of compounded calcium chloride admixtures for peripheral intravenous administration in the setting of a calcium gluconate shortage.
Journal of pharmacy practice, Volume: 27, Issue: 5
2014
Comparison of side effects of pentagastrin test and calcium stimulation test in patients with increased basal calcitonin concentration: the gender-specific differences.
Endocrine, Volume: 46, Issue: 3
2014
Single oral dose toxicity test of polycalcium, a mixed composition of polycan and calcium lactate-gluconate 1:9 (G/G) in SD rat.
Pakistan journal of pharmaceutical sciences, Volume: 26, Issue: 6
2013
Safety and efficacy of polycalcium for improving biomarkers of bone metabolism: a 4-week open-label clinical study.
Journal of medicinal food, Volume: 16, Issue: 3
2013
Safety and efficacy of two potassium cocktail formulations for treatment of neonatal hyperkalemia.
The Annals of pharmacotherapy, Volume: 45, Issue: 11
2011
Intravenous calcium and magnesium for oxaliplatin-induced sensory neurotoxicity in adjuvant colon cancer: NCCTG N04C7.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Feb-01, Volume: 29, Issue: 4
2011
[Assessment of the protective effect of calcium-magnesium infusion and glutathione on oxaliplatin-induced neurotoxicity].
Zhonghua zhong liu za zhi [Chinese journal of oncology], Volume: 32, Issue: 3
2010
Intravenous ceftriaxone and calcium in the neonate: assessing the risk for cardiopulmonary adverse events.
Pediatrics, Volume: 123, Issue: 4
2009
Continuous infusion of calcium gluconate in 5% albumin is safe and prevents most hypocalcemic reactions during therapeutic plasma exchange.
Journal of clinical apheresis, Volume: 22, Issue: 5
2007
Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and doxorubicin.
Pediatric hematology and oncology, Volume: 24, Issue: 6
2007
Management of beta-adrenergic blocker and calcium channel antagonist toxicity.
Emergency medicine clinics of North America, Volume: 25, Issue: 2
2007
Safety and feasibility of autologous myoblast transplantation in patients with ischemic cardiomyopathy: four-year follow-up.
Circulation, Sep-20, Volume: 112, Issue: 12
2005
Prevention of oxaliplatin-related neurotoxicity by calcium and magnesium infusions: a retrospective study of 161 patients receiving oxaliplatin combined with 5-Fluorouracil and leucovorin for advanced colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research, Jun-15, Volume: 10, Issue: 12 Pt 1
2004
The effect of Calcicol as calcium tonic on delayed neurotoxicity induced by organophosphorus compounds.
Toxicology letters, Jun-05, Volume: 143, Issue: 1
2003
[Effect of calcium gluconate on the toxicity and antitumor of doxorubicin in mice].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], Volume: 44, Issue: 1
1999
[The effect of calcium gluconate on the acute and chronic toxicity of doxorubicin in mice].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], Volume: 42, Issue: 1
1997
Calcium supplementation and ototoxicity in patients receiving cisplatin.
British journal of clinical pharmacology, Volume: 42, Issue: 2
1996
Effect of nicardipine on the reversal of magnesium toxicity by calcium gluconate in nonpregnant rabbits.
Obstetrics and gynecology, Volume: 82, Issue: 1
1993
The adverse effects of high oral osmolal mixtures in neonates. A review and a study of the osmolality of calcium preparations.
Clinical pediatrics, Volume: 23, Issue: 9
1984
Acute intravenous infusion of disodium dihydrogen (1-hydroxyethylidene)diphosphonate: mechanism of toxicity.
Journal of pharmaceutical sciences, Volume: 73, Issue: 8
1984
Examination of toxicity of diisopropylammonium dichloracetate (DADA), remedies for cardiac diseases, toward isolated rat hepatocytes.
Meikai Daigaku shigaku zasshi = The Journal of Meikai University School of Dentistry, Volume: 19, Issue: 1
1990
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Long-term Use (3)

ArticleYear
[Sinus bradycardia with junctional rhythm escape reverted with calcium gluconate].
Arquivos brasileiros de cardiologia, Volume: 62, Issue: 5
1994
Suppression of secondary hyperparathyroidism in uraemia: acute and chronic studies.
British medical journal (Clinical research ed.), Jan-21, Volume: 288, Issue: 6412
1984
Effect of calcium and calcium blockers in hypertension.
International journal of clinical pharmacology, therapy, and toxicology, Volume: 28, Issue: 11
1990
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (4)

ArticleYear
ECG manifestations of multiple electrolyte imbalance: peaked T wave to P wave ("tee-pee sign").
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, Volume: 14, Issue: 2
2009
Pharmacokinetics of calcium from calcium supplements in healthy volunteers.
Pakistan journal of pharmaceutical sciences, Volume: 21, Issue: 2
2008
Reduction of adverse citrate reactions during autologous large-volume PBPC apheresis by continuous infusion of calcium-gluconate.
Transfusion, Volume: 43, Issue: 11
2003
Pharmacokinetics of oxytetracycline in presence of calcium gluconate in goats.
Indian journal of physiology and pharmacology, Volume: 36, Issue: 2
1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (10)

ArticleYear
Fabrication and characterization of the nano-composite of whey protein hydrolysate chelated with calcium.
Food & function, Volume: 6, Issue: 3
2015
Spontaneous supersaturation of calcium D-gluconate during isothermal dissolution of calcium L-lactate in aqueous sodium D-gluconate.
Food & function, Volume: 5, Issue: 1
2014
Pharmacokinetics of calcium from calcium supplements in healthy volunteers.
Pakistan journal of pharmaceutical sciences, Volume: 21, Issue: 2
2008
Excipient-excipient interaction in the design of sustained-release theophylline tablets: in vitro and in vivo evaluation.
Drug development and industrial pharmacy, Volume: 27, Issue: 6
2001
The large intestine compensates for insufficient calcium absorption in the small intestine in rats.
Journal of nutritional science and vitaminology, Volume: 44, Issue: 6
1998
Calcium requirements in humans. Report of original data and a review.
Clinical orthopaedics and related research, Issue: 184
1984
Influence of accompanying anion on intestinal radiocalcium absorption.
Calcified tissue international, Volume: 40, Issue: 1
1987
[Intestinal absorption of calcium gluconate and oseine-mineral complex: an evaluation by conventional analyses].
Schweizerische medizinische Wochenschrift, Dec-13, Volume: 116, Issue: 50
1986
Consumer vinegar test for determining calcium disintegration.
American journal of hospital pharmacy, Volume: 49, Issue: 9
1992
Effect of calcium and antacids on phenytoin bioavailability.
Archives of neurology, Volume: 36, Issue: 7
1979
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (35)

ArticleYear
Comparison of neuromuscular blockade recovery co-administered with neostigmine and different doses of calcium gluconate: a randomized control trial.
BMC anesthesiology, 03-29, Volume: 21, Issue: 1
2021
Comparatively Evaluating Medication Preparation Sequences for Treatment of Hyperkalemia in Pediatric Cardiac Arrest: A Prospective, Randomized, Simulation-Based Study.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, Volume: 16, Issue: 7
2015
Effects of Dulaglutide on Thyroid C Cells and Serum Calcitonin in Male Monkeys.
Endocrinology, Volume: 156, Issue: 7
2015
Physical Compatibility of Sodium Glycerophosphate and Calcium Gluconate in Pediatric Parenteral Nutrition Solutions.
JPEN. Journal of parenteral and enteral nutrition, Volume: 39, Issue: 6
2015
Improved time to treatment failure with an intermittent oxaliplatin strategy: results of CONcePT.
Annals of oncology : official journal of the European Society for Medical Oncology, Volume: 25, Issue: 6
2014
Single oral dose toxicity test of polycalcium, a mixed composition of polycan and calcium lactate-gluconate 1:9 (G/G) in SD rat.
Pakistan journal of pharmaceutical sciences, Volume: 26, Issue: 6
2013
A novel dosing regimen for calcium infusion in a patient of massive overdose of sustained-release nifedipine.
The American journal of the medical sciences, Volume: 345, Issue: 3
2013
Biochemical, histopathological and clinical evaluation of delayed effects caused by methamidophos isoforms and TOCP in hens: ameliorative effects using control of calcium homeostasis.
Toxicology, Dec-08, Volume: 302, Issue: 1
2012
High-dose calcium reduces early-onset hyperkalemia in extremely preterm neonates.
Pediatrics international : official journal of the Japan Pediatric Society, Volume: 54, Issue: 6
2012
'Fatal 2,4-dinitrophenol poisoning... coming to a hospital near you'.
Emergency medicine journal : EMJ, Volume: 27, Issue: 8
2010
Intravenous ceftriaxone and calcium in the neonate: assessing the risk for cardiopulmonary adverse events.
Pediatrics, Volume: 123, Issue: 4
2009
Aqueous solvent system for the solubilization of azole compounds.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Feb-15, Volume: 36, Issue: 2-3
2009
Successful amelioration of oxaliplatin-induced hyperexcitability syndrome with the antiepileptic pregabalin in a patient with pancreatic cancer.
Cancer chemotherapy and pharmacology, Volume: 61, Issue: 3
2008
Dose-dependent characteristics of intravenous calcium therapy for hypocalcemic critically ill trauma patients receiving specialized nutritional support.
Nutrition (Burbank, Los Angeles County, Calif.), Volume: 23, Issue: 1
2007
Enhancement of enrofloxacin serum antibacterial activity by calcium primed broilers.
Research in veterinary science, Volume: 82, Issue: 1
2007
Easily reversible hypoxemia and hypotension induced by nimodipine.
European journal of emergency medicine : official journal of the European Society for Emergency Medicine, Volume: 11, Issue: 5
2004
Prevention of oxaliplatin-related neurotoxicity by calcium and magnesium infusions: a retrospective study of 161 patients receiving oxaliplatin combined with 5-Fluorouracil and leucovorin for advanced colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research, Jun-15, Volume: 10, Issue: 12 Pt 1
2004
The effect of Calcicol as calcium tonic on delayed neurotoxicity induced by organophosphorus compounds.
Toxicology letters, Jun-05, Volume: 143, Issue: 1
2003
The use of calcium carbonate in nelfinavir-associated diarrhoea in HIV-1-infected patients.
HIV medicine, Volume: 4, Issue: 1
2003
Calcimimetic compound NPS R-568 stimulates calcitonin secretion but selectively targets parathyroid gland Ca(2+) receptor in rats.
The Journal of pharmacology and experimental therapeutics, Volume: 290, Issue: 2
1999
Effect of intravenous calcium administration on gentamicin-induced nephrotoxicosis in ponies.
American journal of veterinary research, Volume: 59, Issue: 8
1998
[The suitability of 1-alpha-hydroxycholecalciferol for the prevention of recurrent parturient paresis in dairy cows].
Tierarztliche Praxis, Volume: 21, Issue: 1
1993
[Calcitriol administration during pregnancy in a partial DiGeorge anomaly].
Deutsche medizinische Wochenschrift (1946), Dec-23, Volume: 119, Issue: 51-52
1994
Clinical features and management of nifedipine overdosage in a patient with renal insufficiency.
Journal of toxicology. Clinical toxicology, Volume: 22, Issue: 4
1984
Studies of antidote therapy for nisoldipine intoxication in experimental animals.
Arzneimittel-Forschung, Volume: 40, Issue: 7
1990
The effect of a standard oral calcium load given in two different forms on plasma ionized calcium and serum PTH.
Annals of clinical biochemistry, Volume: 28 ( Pt 5)
1991
Hydrofluoric acid dermal burns. An assessment of treatment efficacy using an experimental pig model.
Journal of occupational medicine. : official publication of the Industrial Medical Association, Volume: 34, Issue: 9
1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (4)

ArticleYear
Comparison of neuromuscular blockade recovery co-administered with neostigmine and different doses of calcium gluconate: a randomized control trial.
BMC anesthesiology, 03-29, Volume: 21, Issue: 1
2021
[Treatment of patients with postmenopausal and steroid-induced osteoporosis using sodium fluoride combined with vitamin D2 and calcium gluconate].
Vutreshni bolesti, Volume: 29, Issue: 1
1990
Termination of second trimester pregnancy with intraamniotic administration of 16-phenoxy-omega-tetranor-PgE2-methylsulfonamide (SHB 286) alone and combined with oxytocin and calcium gluconate.
Contraception, Volume: 18, Issue: 6
1978
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]