A serum paraoxonase/arylesterase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P27169]
PON 1;
EC 3.1.1.2;
EC 3.1.1.81;
EC 3.1.8.1;
Aromatic esterase 1;
A-esterase 1;
K-45;
Serum aryldialkylphosphatase 1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-nitrophenylphosphate | Homo sapiens (human) | IC50 | 18,500.0000 | 1 | 1 |
| acetazolamide | Homo sapiens (human) | Ki | 743.0000 | 1 | 1 |
| diclofenac sodium | Homo sapiens (human) | Ki | 805.0000 | 1 | 1 |
| furosemide | Homo sapiens (human) | Ki | 702.0000 | 1 | 1 |
| ifosfamide | Homo sapiens (human) | Ki | 8,973.0000 | 1 | 1 |
| indomethacin | Homo sapiens (human) | Ki | 97.0000 | 1 | 1 |
| ketoprofen | Homo sapiens (human) | Ki | 13,010.0000 | 1 | 1 |
| mafenide | Homo sapiens (human) | Ki | 340.0000 | 1 | 1 |
| sulfacetamide | Homo sapiens (human) | Ki | 86.0000 | 1 | 1 |
| phenylphosphate | Homo sapiens (human) | IC50 | 3,250.0000 | 1 | 1 |
| paclitaxel | Homo sapiens (human) | Ki | 16.5000 | 1 | 1 |
| etoposide | Homo sapiens (human) | Ki | 131.0000 | 1 | 1 |
| 5-amino-1,3,4-thiadiazole-2-sulfonamide | Homo sapiens (human) | Ki | 2,001.0000 | 1 | 1 |
| docetaxel anhydrous | Homo sapiens (human) | Ki | 291.0000 | 1 | 1 |
| clindamycin phosphate | Homo sapiens (human) | Ki | 35,800.0000 | 1 | 1 |
| lincomycin | Homo sapiens (human) | Ki | 18,300.0000 | 1 | 1 |
| t-tucb | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| oxytetracycline, anhydrous | Homo sapiens (human) | Ki | 200.0000 | 1 | 1 |
| mobiflex | Homo sapiens (human) | Ki | 306.0000 | 1 | 1 |
| lornoxicam | Homo sapiens (human) | Ki | 9.0000 | 1 | 1 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| aryldialkylphosphatase activity | molecular function | Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol. [EC:3.1.8.1] |
| arylesterase activity | molecular function | Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. [EC:3.1.1.2] |
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
| phospholipid binding | molecular function | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| acyl-L-homoserine-lactone lactonohydrolase activity | molecular function | Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone = H+ + an N-acyl-L-homoserine. [EC:3.1.1.81] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| blood microparticle | cellular component | A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. [GOC:BHF, GOC:mah, PMID:16373184] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
This protein is part of 2 target(s):
| Target | Category | Definition |
|---|---|---|
| high-density lipoprotein particle | cellular component | A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:pde, GOC:rl] |
| spherical high-density lipoprotein particle | cellular component | A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT). [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] |
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| cholesterol metabolic process | biological process | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. [ISBN:0198506732] |
| response to toxic substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr] |
| positive regulation of cholesterol efflux | biological process | Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:BHF, GOC:dph, GOC:tb] |
| carboxylic acid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. [ISBN:0198506732] |
| organophosphate catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound. [GOC:ai] |
| phosphatidylcholine metabolic process | biological process | The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. [ISBN:0198506732] |
| lactone catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of lactone. [GOC:TermGenie] |