brivudine profile

brivudine: anti-herpes agent [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	446727
CHEMBL ID	31634
SCHEMBL ID	99350
SCHEMBL ID	141408
MeSH ID	M0073782

Synonym
AKOS015833980
nsc-633770
bromovinyldeoxyuridine
zostex
rp-101
a-176
EU-0100175
LOPAC0_000175
D07249
brivudine (inn)
zostex (tn)
brivudine
ua-618
helpin
69304-47-8
bvdu
brvdurd
nsc633770
(e)-5-(2-bromovinyl)-2'-deoxyuridine
5-[(e)-2-bromovinyl]-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione
(e)-5-(2-bromovinyl)-durd
bv-durd
brivudin
(e)-5-(2-bromovinyl)-deoxyuridine
DB03312
BVD ,
5-bromovinyldeoxyuridine
c11h13brn2o5
trans-5-(2-bromovinyl)-2'-deoxyuridine
brivudina [inn-spanish]
nsc 633770
ccris 2831
uridine, 5-(2-bromoethenyl)-2'-deoxy-, (e)-
brivudine [inn]
brivudinum [inn-latin]
uridine, 5-(2-bromovinyl)-2'-deoxy-, (e)-
NCGC00093656-01
NCGC00093656-02
B 9647
B3404
CHEMBL31634
rp101
5-[(e)-2-bromoethenyl]-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
2m3055079h ,
brivudina
brivudinum
unii-2m3055079h
cas-69304-47-8
dtxsid0045755 ,
tox21_111213
dtxcid8025755
CCG-204270
zerpex
bdbm50366681
bridic
brivox
LP00175
brivudine [mi]
5-((e)-2-bromovinyl)-2'-deoxyuridine
brivudine [who-dd]
brivudine [mart.]
S5009
SCHEMBL99350
SCHEMBL141408
bromovinyldeoxyuridine; 5-[(e)-2-bromoethenyl]-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
J-700153
e-5-(2-bromovinyl)-2'-deoxyuridine
ODZBBRURCPAEIQ-PIXDULNESA-N
uridine, 5-[(1e)-2-bromoethenyl]-2'-deoxy-
SR-01000075726-1
sr-01000075726
CS-6292
HY-13578
5-((e)-2-bromovinyl)-1-((2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1h,3h)-dione
5-[(e)-2-bromoethenyl]-2'-deoxyuridine
ZB0745
5-[(e)-2-bromoethenyl]-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
AS-35234
Q904107
SDCCGSBI-0050163.P002
EN300-7413261
BP-58637

Excerpt	Reference
"Brivudine is an analog of thymidine, and is incorporated into the viral DNA. "	( Rabasseda, X, 2003)

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	56.2341	0.0032	45.4673	12,589.2998	AID2517
Chain A, Cruzipain	Trypanosoma cruzi	Potency	3.1623	0.0020	14.6779	39.8107	AID1476
AR protein	Homo sapiens (human)	Potency	19.9620	0.0002	21.2231	8,912.5098	AID743040; AID743042; AID743054
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	0.0251	0.0355	20.9770	89.1251	AID504332
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	25.1189	0.5406	17.6392	96.1227	AID2364; AID2528
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	84.9214	23.9341	23.9341	23.9341	AID1967
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	11.8832	0.0003	23.4451	159.6830	AID743067
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	14.1254	0.0501	27.0736	89.1251	AID588590
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	0.5103	0.0056	12.3677	36.1254	AID624032
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	25.1189	0.0158	12.3113	615.5000	AID1461
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Thymidine kinase	Macacine alphaherpesvirus 1	IC50 (µMol)	32.3000	0.1500	2.5750	4.2000	AID326127
Thymidine kinase, cytosolic	Homo sapiens (human)	Ki	0.1000	0.0900	1.5213	7.0000	AID210688
Thymidine kinase	Human alphaherpesvirus 1 strain SC16	IC50 (µMol)	1,435.1500	0.1000	1.8491	7.9433	AID210531; AID210698
Thymidine kinase	Human alphaherpesvirus 1 (Herpes simplex virus type 1)	Ki	0.2400	0.2400	0.2400	0.2400	AID326128
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
nucleobase-containing compound metabolic process	Thymidine kinase, cytosolic	Homo sapiens (human)
deoxyribonucleoside monophosphate biosynthetic process	Thymidine kinase, cytosolic	Homo sapiens (human)
thymidine metabolic process	Thymidine kinase, cytosolic	Homo sapiens (human)
thymidine biosynthetic process	Thymidine kinase, cytosolic	Homo sapiens (human)
protein homotetramerization	Thymidine kinase, cytosolic	Homo sapiens (human)
DNA synthesis involved in mitotic DNA replication	Thymidine kinase, cytosolic	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
thymidine kinase activity	Thymidine kinase, cytosolic	Homo sapiens (human)
protein binding	Thymidine kinase, cytosolic	Homo sapiens (human)
ATP binding	Thymidine kinase, cytosolic	Homo sapiens (human)
zinc ion binding	Thymidine kinase, cytosolic	Homo sapiens (human)
identical protein binding	Thymidine kinase, cytosolic	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nucleus	Thymidine kinase, cytosolic	Homo sapiens (human)
cytosol	Thymidine kinase, cytosolic	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1277)

Assay ID	Title	Year	Journal	Article
AID634748	Antiviral activity against thymidine kinase-deficient acv-resistant Herpes simplex virus 1 KOS infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID161459	Antiviral activity against Vaccinia virus in primary rabbit kidney cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID665388	Cytotoxicity against human HEL cells assessed as change in cell morphology by microscopic analysis	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and antiviral evaluation of C5-substituted-(1,3-diyne)-2'-deoxyuridines.
AID1457769	Cytotoxic activity against HEL cells assessed as alteration of cell morphology after 3 days by microscopic method	2017	Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14	Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
AID296675	Antiviral activity against thymidine kinase deficient VZV YS/R in HEL cells assessed as reduction of virus plaque formation after 5 days	2007	Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16	Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.
AID303210	Antiviral activity against acyclovir-resistant HSV1 KOS TK- in HEL cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID260291	Antiviral activity against TK+ VZV OKA in human embryonic lung cells	2006	Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4	Inactivation of S-adenosyl-L-homocysteine hydrolase by 6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine and 6'-chloro-6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine. Antiviral and cytotoxic effects.
AID84072	Compound was evaluated for antiviral activity against HSV-1(strain KOS)	1984	Journal of medicinal chemistry, Mar, Volume: 27, Issue:3	Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.
AID303214	Antiviral activity against VZV 07-1 TK- in HEL cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID229025	Inhibitory activity against vaccinia virus (VV) replication in E6SM cell cultures of human embryonic skin-muscle	2002	Journal of medicinal chemistry, Dec-05, Volume: 45, Issue:25	A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.
AID1652586	Antiviral activity against HIV2 ROD infected in human CEM/0 cells assessed as inhibition of viral-induced giant cell formation incubated for 4 to 5 days by microscopy
AID63767	The minimum inhibitory concentration was measured on E6SM cells against Vesicular stomatitis virus	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID161451	Antiviral activity against 196 strain of herpes simplex virus-2 in primary rabbit kidney cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID82532	50% Cytostatic concentration required to inhibit human erythroleukemic (HEL) cell proliferation	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID463989	Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID81189	Concentration required to inhibit VZV (YS) induced cytopathogenicity in HEL cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID167881	Antiviral Activity against herpes simplex virus-2 (196) in rabbit kidney cell	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID434310	Antiviral activity against sVesicular stomatitis virus infected in HEL cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID165523	Concentration of compound required to inhibit [1',2'-3H]dUrd incorporation into host cell DNA by 50% in primary rabbit kidney cell cultures	1984	Journal of medicinal chemistry, Mar, Volume: 27, Issue:3	Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.
AID1572736	Antiviral activity against Human cytomegalovirus Davis assessed as reduction in virus-induced cytopathogenicity by microscopic analysis	2019	Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6	Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID1294502	Cytotoxicity against human Jurkat cells assessed as reduction in cell viability after 72 hrs by MTS assay	2016	Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9	L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation.
AID167879	Antiviral Activity against herpes simplex virus-1 TK- VMW 1837 in rabbit kidney cell	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID82896	Tested for the inhibitory concentration required to reduce TK+ Varicella-Zoster virus (TK+ VZV) strain YS plaque formation by 50%	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID1230101	Antiviral activity against thymidine kinase-deficient Varicella-zoster virus infected in HEL cells assessed as reduction of virus-induced plaque formation	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues.
AID303213	Antiviral activity against VZV OKA in HEL cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID66790	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 100 ug/mL of dUrd	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID1652587	Antiviral activity against HIV2 ROD infected in human TK-deficient CEM/TK(-) cells assessed as inhibition of viral-induced giant cell formation incubated for 4 to 5 days by microscopy
AID85716	Antiviral activity against Herpes Simplex Virus-1(KOS)	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis and antitumor and antiviral properties of 5-alkyl-2'-deoxyuridines, 3',5'-cyclic monophosphates, and neutral cyclic triesters.
AID81037	The compound was tested for antiviral activity by measuring the concentration required to reduce plaque formation against cytomegalo virus Davis strain; Not determined	1999	Journal of medicinal chemistry, Jul-15, Volume: 42, Issue:14	Novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis and biological evaluation.
AID1410511	Cytotoxicity against HEL cells assessed as reduction in cell viability after 3 days by coulter counting method	2018	ACS medicinal chemistry letters, Apr-12, Volume: 9, Issue:4	Amidate Prodrugs of Cyclic 9-(
AID87979	Minimum inhibitory concentration causing 50% inhibition of cytopathic effect induced by HSV-1(thymidine kinase deficient) in PRK cells	1988	Journal of medicinal chemistry, Sep, Volume: 31, Issue:9	Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
AID419596	Antiviral activity against thymidine kinase-deficient acyclovir-resistant HSV1 KOS infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity after 3 days	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID64103	Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-1 (KOS) was measured	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID151172	Minimum cytotoxic concentration that causes alterations of VZV infected Osteosarcoma cell morphology	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID1498126	Antiviral activity against thymidine kinase expressing Varicella-Zoster virus infected in HEL cells assessed as reduction in virus plaque formation	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.
AID309810	Antiviral activity against TK+ VZV OKA in HEL cells assessed as reduction of virus plaque formation	2007	Bioorganic & medicinal chemistry, Nov-15, Volume: 15, Issue:22	Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV).
AID434321	Cytotoxicity against african green monkey Vero cells assessed as change in cell morphology	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID83207	The minimum inhibitory concentration was measured on HEL cells against Cytomegalovirus virus (AD-169 strain)	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID280203	Cytotoxicity against E6SM cells assessed as alteration in cell morphology	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID1427837	Cytotoxicity against virus infected HEL cells assessed as alteration in cell morphology by microscopic method
AID1462038	Antiviral activity against Vaccinia virus Lederle infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID156707	Evaluation for antiviral activity against herpes simplex virus-2(G) in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID482705	Antiviral activity against VSV infected in human E6SM cell assessed as inhibition of virus-induced cytopathicity	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	"Viologen" dendrimers as antiviral agents: the effect of charge number and distance.
AID217971	Compound was tested for antiviral activity against Vaccinia virus in primary rabbit kidney cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID658740	Antiviral activity against thymidine kinase-deficient acyclovir-resistant HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID217594	In vitro antiviral activity was determined by plaque-reduction assay in HSV-2 (strain G) infected Vero cell monolayers	1984	Journal of medicinal chemistry, Jan, Volume: 27, Issue:1	Nucleosides. 129. Synthesis of antiviral nucleosides: 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracils.
AID156710	Evaluation for antiviral activity against vesicular stomatitis virus in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID218000	Evaluated for the minimum inhibitory concentration (MIC) in primary rabbit kidney (PRK) by 50% against vaccinia virus	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID85127	Inhibitory activity against HSV-2 (Lyons) replication in E6SM cell cultures of human embryonic skin-muscle	2002	Journal of medicinal chemistry, Dec-05, Volume: 45, Issue:25	A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.
AID85718	Concentration required to reduce HSV-1 virus induced cytopathogenicity in rabbit cell kidney culture (F cells)	1988	Journal of medicinal chemistry, Jan, Volume: 31, Issue:1	Synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2'-deoxycytidine-related compounds.
AID66779	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 1 ug/mL of Urd and 50 ug/mL of 6-aminothymine	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID105822	Minimum inhibitory concentration required to reduce cytopathogenicity of Cytomegalovirus Virus (CMV) in MRC-5 cells by 50%.	1991	Journal of medicinal chemistry, Sep, Volume: 34, Issue:9	The synthesis and antiviral activity of some 4'-thio-2'-deoxy nucleoside analogues.
AID156694	Evaluation in PRK cell cultures for cytotoxicity that is to cause microscopically detectable alteration of normal cell morphology	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID296672	Antiviral activity against TK+ VZV YS in HEL cells assessed as reduction of virus plaque formation after 5 days	2007	Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16	Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.
AID539915	Antiviral activity against Herpes simplex virus-1 KOS infected in human HEL cells assessed as protection against virus-induced cytopathogenicity after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID1572735	Antiviral activity against Human cytomegalovirus AD169 assessed as reduction in virus-induced cytopathogenicity by microscopic analysis	2019	Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6	Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID246464	Concentration required to inhibit Varicella-Zoster virus (strain OKA) induced cytopathogenicity in HEL cells by 50%	2005	Journal of medicinal chemistry, Jul-14, Volume: 48, Issue:14	Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.
AID218132	Evaluation of antiviral activity against Vaccinia virus	1986	Journal of medicinal chemistry, Jul, Volume: 29, Issue:7	Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID257895	Antiviral activity against Reovirus 1 in vero cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID516964	Cytotoxicity against HEL	2010	Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19	Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents.
AID63619	Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-1) strain McIntyre induced cytopathogenicity by 50%.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID539917	Antiviral activity against Vaccinia virus infected in human HEL cells assessed as protection against virus-induced cytopathogenicity after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID85113	Minimum inhibitory concentration was determined against HSV-2 (196) in E6SM cell culture	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID216388	Concentration required to reduce cytopathogenicity of Vesicular stomatitis virus by 50% in primary rabbit kidney (PRK) cells	1984	Journal of medicinal chemistry, Nov, Volume: 27, Issue:11	Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID66000	Tested for the minimum cytotoxic concentration required to cause a microscopically detectable alteration of normal cell morphology in human embryonic skin muscle (E6SM) fibroblast cell cultures.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID65705	Minimum cytotoxic concentration required to cause a microscopically detectable alteration of normal cell morphology	2001	Journal of medicinal chemistry, Aug-02, Volume: 44, Issue:16	Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
AID217899	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against coxsackie B4 virus in Vero cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID81203	Minimum inhibitory concentration required to reduce virus induced plaque formation in HEL cell culture of virus TK- VZV (07-1) was measured	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID167150	Minimum cytotoxic concentration causing toxic effects on uninfected cells in rabbit	1988	Journal of medicinal chemistry, Sep, Volume: 31, Issue:9	Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
AID257889	Antiviral activity against Herpes simplex virus 1 KOS strain in HEL cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID1710790	Antiviral activity against Herpes simplex virus 1 infected in human HEL cells assessed as reduction in virus-induced cytopathic effect incubated for 3 to 6 days by light microscopic analysis	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	Synthesis and antiviral properties of novel indole-based thiosemicarbazides and 4-thiazolidinones.
AID216479	Antiviral activity was tested against TK- Varicella-Zoster virus YS/R which reduces virus plaque formation by 50%	2002	Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19	Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles.
AID567091	Drug absorption in human assessed as human intestinal absorption rate	2011	European journal of medicinal chemistry, Jan, Volume: 46, Issue:1	Prediction of drug intestinal absorption by new linear and non-linear QSPR.
AID84230	Minimum inhibitory concentration was determined against HSV-1 (McIntyre) in E6SM cell culture	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID105823	Minimum inhibitory concentration required to reduce cytopathogenicity of Herpes Virus-1 (HSV-1) in MRC -5 cells by 50%.	1991	Journal of medicinal chemistry, Sep, Volume: 34, Issue:9	The synthesis and antiviral activity of some 4'-thio-2'-deoxy nucleoside analogues.
AID84420	Compound was tested for antiviral activity against herpes simplex virus( HSV-1-McIntyre) strain in primary rabbit kidney cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID120303	In vivo evaluation for the percent survivors in systemic HSV-1 infection of Mice administered through oral route at a dose 25 mg/kg per day	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID280188	Cytotoxicity against HEL cells assessed as inhibition of cell growth after 3 days	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID303232	Antiviral activity against RSV in HeLa cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID260294	Cytotoxicity against HEL cells	2006	Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4	Inactivation of S-adenosyl-L-homocysteine hydrolase by 6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine and 6'-chloro-6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine. Antiviral and cytotoxic effects.
AID1394846	Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as inhibition of plaque formation measured after 6 to 7 days post infection	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates.
AID81053	Concentration required to inhibit CMV (Davis) induced cytopathogenicity in HEL cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID209532	Inhibitory concentration against TK-HSV type 1 strain B2006 in human embryonic skin muscle (ESM) fibroblast cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID257893	Antiviral activity against herpes simplex virus 1 TK- KOS ACVr strain in HEL cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID1402824	Antiviral activity against TK-positive VZV Oka infected in HEL cells assessed as reduction in plaque formation after 5 days	2018	European journal of medicinal chemistry, Jan-20, Volume: 144	Emimycin and its nucleoside derivatives: Synthesis and antiviral activity.
AID120297	In vivo evaluation for the percent survivors in systemic HSV-1 infection of Mice administered through intraperitoneal at a dose 2.5 mg/kg per day; NT=Not tested	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID87197	Antiherpes activity was tested as percent of control of plaque-formation against HSV-1 (KOS) virus by 30 uM of the compound	1985	Journal of medicinal chemistry, Jul, Volume: 28, Issue:7	Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID220079	Antiviral activity against YS strain of thymidine kinase positive(TK+) Varicella-Zoster Virus (VZV)	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID218519	Antiviral activity against HSV-2 (Herpes simplex virus) in vero cells	1994	Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1	S-glucosylated hydantoins as new antiviral agents.
AID275067	Antiviral activity against HSV1 KOS in HEL cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID1251995	Antiviral activity against thymidine kinase-deficient Varicella zoster virus Oka infected in HEL cells assessed as reduction in viral plaque formation	2015	Bioorganic & medicinal chemistry, Nov-01, Volume: 23, Issue:21	Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides.
AID64084	Concentration required to inhibit HSV-1 (KOS) induced cytopathogenicity in E6SM cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID84225	Minimum inhibitory concentration was determined against HSV-1 (KOS) in E6SM cell culture	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID687667	Cytotoxicity against HEL after 3 days	2012	European journal of medicinal chemistry, Nov, Volume: 57	Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4'-phosphono-but-2'-en-1'-yl]purine nucleosides.
AID167744	Antiviral Activity against herpes simplex virus-1 (F) in rabbit kidney cell	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID44365	Compound was evaluated for the cytotoxicity against human T-cell leukemia, CCRF-HSB-2 by using MTT assay.	1999	Bioorganic & medicinal chemistry letters, Mar-22, Volume: 9, Issue:6	Synthesis of novel 4'-C-methyl-pyrimidine nucleosides and their biological activities.
AID63609	Tested for antiviral activity against vaccinia virus in human embryonic skin muscle fibroblast	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID383516	Antiviral activity against Vaccinia virus in human E6SM cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID88195	Cytotoxic concentration required to cause microscopically detectable alteration of normal cell morphology of HeLa cells	1996	Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14	Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.
AID84240	Minimum inhibitory concentration was determined against HSV-1 (TK-/TK+VMW1837) in E6SM cell culture	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID1462036	Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID675211	Antiviral activity against thymidine kinase positive VZV OKa infected in HEL cells by plaque formation assay	2012	European journal of medicinal chemistry, Sep, Volume: 55	Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
AID83192	Minimum inhibitory conc. for 50% inhibition of TK-VZV (YS/R) virus plaque formation in HEL cells	1997	Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9	Carbocyclic oxetanocins lacking the C-3' methylene.
AID1427825	Antiviral activity against thymidine kinase expressing Varicella-Zoster virus OKA infected in HEL cells assessed as reduction in virus plaque formation
AID210531	Inhibitory concentration against Herpes simplex virus type 1 thymidine kinase(HSV-1 TK)	2001	Bioorganic & medicinal chemistry letters, May-21, Volume: 11, Issue:10	Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.
AID167883	Antiviral Activity against herpes simplex virus-2 (G) in rabbit kidney cell	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID553343	Antiviral activity against thymidine kinase-deficient VZV 07/1 infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 5 days	2011	Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1	Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.
AID383507	Antiviral activity against vesicular stomatitis virus in human HeLa cells assessed as inhibition of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID86208	Proliferation of Hep-2 cells by propagation on day 4 by measuring optical density (absorbance) at 30 ug/mL	1987	Journal of medicinal chemistry, Jul, Volume: 30, Issue:7	2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID303234	Antiviral activity against Reovirus 1 in Vero cells reduction of virus-induced cytopathogenicity after 4 days	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID482712	Antiviral activity against Reovirus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathicity	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	"Viologen" dendrimers as antiviral agents: the effect of charge number and distance.
AID291032	Cytotoxicity against HEL cells assessed as cell growth after 7 days	2007	Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13	Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
AID218385	Cytotoxic activity against vero cells was evaluated.	1985	Journal of medicinal chemistry, Jun, Volume: 28, Issue:6	Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents.
AID216247	Minimum inhibitory concentration required to reduce vesicular stomatis virus-induced cytopathogenicity in primary rabbit kidney cell cultures	1981	Journal of medicinal chemistry, Jun, Volume: 24, Issue:6	Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID209957	The compound was tested for its antiviral activity against HSV-1 (KOS) virus in T-21 (LR) cell line	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID118654	Compound was evaluated in nu/nu mice infected with TK- HSV-1 (VMW-1837) to increase the mean survival time when administered intraperitoneally at 100 mg/kg per day after 39 days	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID419591	Cytotoxicity against human HEL cells assessed as alteration in cell morphology	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID216475	Antiviral activity was tested against TK+ Varicella-Zoster virus YS which reduces virus plaque formation by 50%	2002	Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19	Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles.
AID86207	Proliferation of Hep-2 cells by propagation on day 4 by measuring optical density (absorbance) at 100 ug/mL	1987	Journal of medicinal chemistry, Jul, Volume: 30, Issue:7	2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID63751	Tested for the minimum inhibitory concentration required to reduce thymidine kinase deficient herpes simplex virus type 1 (TK- HSV-1) strain B2006 induced cytopathogenicity by 50%.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID1337440	Antiviral activity against thymidine kinase-deficient acyclovir-resistant Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus plaque formation	2016	European journal of medicinal chemistry, Nov-29, Volume: 124	Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor.
AID96607	Compound was tested for antitumor activity against L1210 cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID63623	Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-2) strain G induced cytopathogenicity by 50%.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID85373	Inhibitory concentration against HSV type 1 strain KOS in human embryonic skin muscle (ESM) fibroblast cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID216300	Compound was evaluated for the inhibition of VZV (TK-) thymidine kinases Strain 07	1999	Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22	Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base.
AID432172	Antiviral activity against Vesicular stomatitis virus infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 3 days	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID133911	Mean time survival (MTS) of the mice at the end of 28 or 49 days.	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID85405	Antiviral activity against HSV-1 kinase mutant resistant to SCS(parental) was determined at a conc of 30 uM	1987	Journal of medicinal chemistry, Nov, Volume: 30, Issue:11	Acetylenic nucleosides. 4. 1-beta-D-arabinofuranosyl-5-ethynylcytosine. Improved synthesis and evaluation of biochemical and antiviral properties.
AID539914	Cytotoxicity against human HEL cells assessed as minimum concentration required to cause microscopically detectable alteration after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID434308	Antiviral activity against Herpes simplex virus 2 infected in HEL cells assessed as protection against in virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID87507	Evaluation of antiviral activity against Herpes simplex virus type 1 (HSV-1) strain KOS.	1986	Journal of medicinal chemistry, Jul, Volume: 29, Issue:7	Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID167884	Antiviral Activity against herpes simplex virus-2 (Lyons) in rabbit kidney cell	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID221459	Evaluated for the minimum inhibitory concentration (MIC) in primary rabbit kidney (PRK) by 50% against herpes simplex virus type-2 (HSV-2) with strains Lyons	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID432176	Antiviral activity against HSV1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 3 days	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID87978	Minimum inhibitory concentration causing 50% inhibition of cytopathic effect induced by HSV-1 in PRK cells	1988	Journal of medicinal chemistry, Sep, Volume: 31, Issue:9	Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
AID68278	Inhibitory concentration required for morphologic alteration in normal cell in human embryonic skin muscle (ESM) fibroblast cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID1410504	Antiviral activity against ACV-resistant thymidine kinase deficient Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect measured after 2 to 3 days post-infection	2018	ACS medicinal chemistry letters, Apr-12, Volume: 9, Issue:4	Amidate Prodrugs of Cyclic 9-(
AID224702	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 25 mg/kg at day 9	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID65709	Antiviral activity against herpes simplex virus-1 TK-KOS ACV (HSV-1) in E6SM cell cultures	2001	Journal of medicinal chemistry, Aug-02, Volume: 44, Issue:16	Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
AID156706	Evaluation for antiviral activity against herpes simplex virus-2(196) in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID111522	Tested for the appearance of skin lesions or paralysis of the legs after 52 days when applied topically at 10% after 52 days	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID83047	50% Minimum inhibitory concentration which is required to reduce cytopathogenicity induced by (KOS) strain of HSV-1 virus on human embryonic HEL cells.	1997	Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4	Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.
AID85253	Compound was evaluated for the antiviral activity against Herpes simplex virus type 2 (HSV-2) MS strain by using plaque reduction assay.	1999	Bioorganic & medicinal chemistry letters, Mar-22, Volume: 9, Issue:6	Synthesis of novel 4'-C-methyl-pyrimidine nucleosides and their biological activities.
AID1394852	Cytotoxicity against HEL cells assessed as alteration in cell morphology after 3 days by microscopic analysis	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates.
AID63592	Minimum inhibitory conc. for 50% inhibition of HSV-1 (KOS) virus induced cytopathicity in E6SM cells	1997	Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9	Carbocyclic oxetanocins lacking the C-3' methylene.
AID766699	Antiviral activity against Herpes simplex virus-2 G infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID83049	50% Minimum inhibitory concentration which is required to reduce cytopathogenicity induced by (Mc Intyre) strain of HSV-1 virus on human embryonic HEL cells.	1997	Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4	Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.
AID216200	Tested for cytotoxic activity in African green monkey kidney cells (Vero)	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID110459	Cumulative mortality in percent of HSV-1 infected mice, after peroral administration of 100 mg/kg of compound	1988	Journal of medicinal chemistry, Sep, Volume: 31, Issue:9	Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
AID87191	Concentration that protects by 50% the cytopathic effect induced by herpes simplex virus - 1.	1985	Journal of medicinal chemistry, Jan, Volume: 28, Issue:1	Uridine 5'-diphosphate glucose analogues. Inhibitors of protein glycosylation that show antiviral activity.
AID416777	Antiviral activity against thymidine kinase deficient and acyclovir resistant HSV1 KOS in human HEL cells assessed as protection against virus-induced cytopathicity	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID1684810	Selectivity index, ratio of CC50 for human HEL cells to EC50 for antiviral activity against thymidine kinase deficient Varicella zoster virus 07-1 infected in human HEL cells	2021	ACS medicinal chemistry letters, Jan-14, Volume: 12, Issue:1	Influence of 4'-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2.
AID1572730	Antiviral activity against herpes simplex virus 2 G infected in HEL cells assessed as reduction in virus-induced cytopathogenicity by microscopic analysis	2019	Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6	Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID216158	Anti-viral activity which is required for the inhibition of VZV (Varicella zoster virus )	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and antiviral activity of 3'-deoxy-3'-C-hydroxymethyl nucleosides.
AID284531	Antiviral activity against in Vesicular stomatitis virus-induced cytopathogenicity in E6SM cells	2007	Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2	The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
AID81032	The compound was tested for antiviral activity by measuring the concentration required to reduce plaque formation against Varicella zoster TK-(deficient) YS/R strain	1999	Journal of medicinal chemistry, Jul-15, Volume: 42, Issue:14	Novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis and biological evaluation.
AID218133	Antiviral activity against vaccinia virus	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis and antitumor and antiviral properties of 5-alkyl-2'-deoxyuridines, 3',5'-cyclic monophosphates, and neutral cyclic triesters.
AID66783	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 10 ug/mL of Urd	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID569239	Cytotoxicity against HEL cells after 3 days by coulter counter analysis	2011	European journal of medicinal chemistry, Feb, Volume: 46, Issue:2	Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation.
AID66958	Effective concentration to show 50% of activity was measured on Epstein Barr virus(EBV) cell culture	2000	Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13	Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses.
AID766703	Antiviral activity against thymidine kinase negative Varicella-zoster virus 07-1 infected in human HEL cells assessed as reduction in the virus plaque formation	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID432171	Antiviral activity against Vaccinia virus infected in in human HEL cells assessed as inhibition of virus-induced cytopathicity after 3 days	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID326135	Antiviral activity against Herpes B virus 32425 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID1572734	Antiviral activity against thymidine kinase deficient Varicella-zoster virus 07-1 infected in HEL cells assessed as reduction in virus plaque formation	2019	Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6	Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID1854968	Antiviral activity against Vaccinia virus infected in HEL cells assessed as reduction in virus-induced cytopathic effect by microscopic analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Synthesis and antiviral properties of biomimetic iminosugar-based nucleosides.
AID1684812	Cytotoxicity against human HEL cells assessed as reduce in cell growth incubated for 3 days by coulter counter analysis	2021	ACS medicinal chemistry letters, Jan-14, Volume: 12, Issue:1	Influence of 4'-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2.
AID260292	Antiviral activity against TK- VZV 07/10 in human embryonic lung cells	2006	Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4	Inactivation of S-adenosyl-L-homocysteine hydrolase by 6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine and 6'-chloro-6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine. Antiviral and cytotoxic effects.
AID280941	Cytotoxicity against mouse L1210/0 cells after 48 hrs	2007	Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7	Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
AID42109	The compound was tested for its antiviral activity against HSV-1 (KOS) virus in BS-C-1A cell line	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID634755	Antiviral activity against Parainfluenza-3 virus infected in african green monkey Vero cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID64114	Minimum inhibitory concentration required to to cause a microscopically detectable change in normal cell morphology	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID65708	Antiviral activity against herpes simplex virus-1 KOS (HSV-1) in E6SM cell cultures	2001	Journal of medicinal chemistry, Aug-02, Volume: 44, Issue:16	Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
AID393981	Cytotoxicity against human HEL cells assessed as morphological alteration after 3 days	2009	Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6	4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus.
AID227702	Ratio of ID50 for dThd or dUrd incorporation to ID50 for HSV-1, HSV-2 or VV(whatever was lowest)	1984	Journal of medicinal chemistry, Nov, Volume: 27, Issue:11	Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID1328758	Cytostatic activity against human HeLa cells after 3 days by cell counting method	2016	Bioorganic & medicinal chemistry letters, 12-01, Volume: 26, Issue:23	ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites.
AID167886	Antiviral Activity against vaccinia virus in rabbit kidney cell	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID228285	Cytotoxic concentration that produces 50% inhibition of cell growth.	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID482702	Antiviral activity against HSV1 KOS infected in human E6SM cell assessed as inhibition of virus-induced cytopathicity	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	"Viologen" dendrimers as antiviral agents: the effect of charge number and distance.
AID66004	50% Minimum inhibitory concentration which is required to reduce cytopathogenicity induced by (KOS) strain of HSV-1 virus on human E6SM cells.	1997	Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4	Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.
AID217757	In vitro antiviral activity against HSV-1(strain HFEM) in Vero cells	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Synthesis and antiviral properties of 5-(2-substituted vinyl)-6-aza-2'-deoxyuridines.
AID1462033	Antiviral activity against thymidine kinase-deficient ACV-resistant Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID66939	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against HSV-1 virus in E6SM cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID280204	Cytotoxicity against HeLa cells assessed as alteration in cell morphology	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID68124	Concentration required to reduce vesicular stomatitis virus(VSV) induced cytopathogenicity by 50% in ESM(embryonic skin muscle) cell cultures.	1992	Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12	(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties.
AID120295	In vivo evaluation for the percent survivors in systemic HSV-1 infection of Mice administered through intraperitoneal at a dose 10 mg/kg per day	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID66769	The compound was tested for its antiviral activity against HSV-2 (Lyons) virus in E6SM cell culture	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID84256	Compound was evaluated for the antiviral activity against Herpes simplex virus type 1 (HSV-1) VR-3 strain by using plaque reduction assay.	1999	Bioorganic & medicinal chemistry letters, Mar-22, Volume: 9, Issue:6	Synthesis of novel 4'-C-methyl-pyrimidine nucleosides and their biological activities.
AID553338	Antiviral activity against HSV2 G infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days	2011	Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1	Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.
AID1251996	Antiviral activity against thymidine kinase-positive Varicella zoster virus 07-1 infected in HEL cells assessed as reduction in viral plaque formation	2015	Bioorganic & medicinal chemistry, Nov-01, Volume: 23, Issue:21	Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides.
AID217905	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against sindbis virus in Vero cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID83535	Minimum cytotoxic concentration that causes a microscopically detectable alteration of cell morphology in human embryonic lung cells	1999	Journal of medicinal chemistry, Jul-15, Volume: 42, Issue:14	Novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis and biological evaluation.
AID66770	The compound was tested for its antiviral activity against TK-HSV-1 (B2006) virus in E6SM cell culture	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID120298	In vivo evaluation for the percent survivors in systemic HSV-1 infection of Mice administered through intraperitoneal at a dose 50 mg/kg per day	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID611615	Antiviral activity against Human herpesvirus 1 KOS infected in HEL cells assessed as protection against virus-induced cytopathicity	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	New prodrugs of Adefovir and Cidofovir.
AID675210	Antiviral activity against thymidine kinase positive VZV YS infected in HEL cells by plaque formation assay	2012	European journal of medicinal chemistry, Sep, Volume: 55	Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
AID120293	In vivo evaluation for the percent survivors in systemic HSV-1 infection of Mice administered through at a dose 25 mg/kg per day	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID291029	Antiviral activity against thymidine kinase expressing Varicella-Zoster virus OKA assessed as reduction of plaque formation	2007	Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13	Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
AID1498127	Antiviral activity against thymidine kinase deficient Varicella-Zoster virus infected in HEL cells assessed as reduction in virus plaque formation	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.
AID434319	Antiviral activity against Punta Toro virus infected in african green monkey Vero cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID86023	Inhibition of plaque formation in monolayers of HSV-1 KOSSB(TK-) Vero cells by 50%	2001	Journal of medicinal chemistry, Oct-11, Volume: 44, Issue:21	Synthesis and antiviral activity of novel 5-(1-cyanamido-2-haloethyl) and 5-(1-hydroxy(or methoxy)-2-azidoethyl) analogues of uracil nucleosides.
AID1854967	Antiviral activity against thymidine kinase deficient Varicella zoster-virus O7-1 strain infected in HEL cells assessed as reduction in plaque formation by microscopic analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Synthesis and antiviral properties of biomimetic iminosugar-based nucleosides.
AID217489	Minimal inhibitory concentration to reduce virus-induced cytopathicity against VV	2001	Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24	Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study.
AID1337434	Antiviral activity against thymidine kinase deficient Varicella-Zoster virus 07-1 infected in HEL cells assessed as inhibition of virus plaque formation	2016	European journal of medicinal chemistry, Nov-29, Volume: 124	Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor.
AID1854963	Antiviral activity against thymidine kinase deficient mutant Acyclovir resistant HSV-1 KOS strain infected in HEL cells assessed as reduction in virus-induced cytopathic effect by microscopic analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Synthesis and antiviral properties of biomimetic iminosugar-based nucleosides.
AID1409609	Cytotoxicity of compound against Vero E6 cells by MTT assay.	2020	Nature, 07, Volume: 583, Issue:7816	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
AID84588	Minimal inhibitory concentration to reduce virus-induced cytopathicity against F strain of human Herpes Simplex Virus-1 (HSV-1)	2001	Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24	Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study.
AID209539	Inhibitory concentration against TK-VZV strain YS-R in human embryonic lung (HEL) cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID156685	Inhibitory concentration required to reduce incorporation of 2-deoxythymidine (dThd) into DNA of Primary Rabbit kidney (PRK) cell cultures	1984	Journal of medicinal chemistry, Nov, Volume: 27, Issue:11	Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID85559	Concentration required to reduce the number of viral plaques in vivo cell monolayers of herpes simplex virus type 1.	1989	Journal of medicinal chemistry, Feb, Volume: 32, Issue:2	Synthesis and antiviral activity of phosphonoacetic and phosphonoformic acid esters of 5-bromo-2'-deoxyuridine and related pyrimidine nucleosides and acyclonucleosides.
AID434315	Antiviral activity against Parainfluenza-3 virus infected in african green monkey Vero cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID87826	Evaluation of antiviral activity against Herpes simplex virus type 2 (HSV-2) strain 196.	1986	Journal of medicinal chemistry, Jul, Volume: 29, Issue:7	Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID432170	Antiviral activity against HSV2 G infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 3 days	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID464178	Cytotoxicity against Herpes simplex virus 1 KOS infected HEL cells by trypan blue exclusion method	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID258994	Cytotoxic activity against cultured human embryonic lung (HEL) cells	2006	Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1	Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivatives.
AID85423	Minimal inhibitory concentration to reduce virus-induced cytopathicity against Lyons strain of human Herpes Simplex Virus-2	2001	Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24	Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study.
AID392512	Antiviral activity against Herpes simplex virus 2	2009	Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2	Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
AID280180	Antiviral activity against TK- VZV 07-1 in HEL cells assessed as inhibition of plaque formation	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID607907	Antiviral activity against acyclovir-resistant TK-deficient Herpes simplex virus-1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis	2011	Bioorganic & medicinal chemistry, Jul-15, Volume: 19, Issue:14	Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
AID383527	Antiviral activity against TK+ VZV OKA infected HEL cells assessed as reduction in virus plaque formation	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID87147	Evaluation for antiviral activity against polio virus-1 in HeLa cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID120299	In vivo evaluation for the percent survivors in systemic HSV-1 infection of Mice administered through intraperitoneal at a dose 5 mg/kg per day	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID768207	Cytotoxicity against human HEL cells	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID1661187	Antiviral activity against Cytomegalovirus AD169 infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity measured after 6 to 7 days	2020	ACS medicinal chemistry letters, Jul-09, Volume: 11, Issue:7	Amidate Prodrugs of
AID392515	Antiviral activity against Human cytomegalovirus	2009	Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2	Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
AID434307	Antiviral activity against HSV1 KOS infected in HEL cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID482707	Antiviral activity against VSV infected in human HeLa cell assessed as inhibition of virus-induced cytopathicity	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	"Viologen" dendrimers as antiviral agents: the effect of charge number and distance.
AID83332	The minimum inhibitory concentration was measured on HEL cells against Varicella zoster virus (YS strain)	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID1462039	Cytotoxicity against HEL cells assessed as alteration of cell morphology by microscopic analysis	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID167140	Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against Vesicular stomatitis virus	1983	Journal of medicinal chemistry, Apr, Volume: 26, Issue:4	Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID1409608	AUC (viral infection %) for SARS-CoV-2 in the Vero E6 cell line at 48 h by immunofluorescence-based assay (detecting the viral NP protein in the nucleus of the Vero E6 cells).	2020	Nature, 07, Volume: 583, Issue:7816	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
AID87322	Antiherpes activity was tested as percent of control of plaque-formation against HSV-2 (333) virus by 30 uM of the compound	1985	Journal of medicinal chemistry, Jul, Volume: 28, Issue:7	Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID275087	Cytotoxicity against HEL cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID291037	Antiviral activity against coxsackie B4 virus in HeLa cells assessed as reduction of virus plaque formation after 7 days	2007	Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13	Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
AID85717	Antiviral activity against Herpes Simplex Virus-1 (McIntyre)	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis and antitumor and antiviral properties of 5-alkyl-2'-deoxyuridines, 3',5'-cyclic monophosphates, and neutral cyclic triesters.
AID224695	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 100 mg/kg at day 6	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID66005	50% Minimum inhibitory concentration which is required to reduce cytopathogenicity induced by (Lyons) strain of HSV-2 virus on human E6SM cells.	1997	Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4	Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.
AID83183	Concentration required to reduce varicella zoster virus(VZV)OKA plaque formation by 50% at 20 plaque forming units(PFU) in human embryonic lung (HEL) cell cultures.	1992	Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12	(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties.
AID1457770	Cytotoxic activity against HEL cells assessed as reduction in cell proliferation after 3 days by coulter counting method	2017	Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14	Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
AID64108	Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-2 (G) was measured	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID68121	Concentration required to reduce HSV-1(KOS) induced cytopathogenicity by 50% in ESM(embryonic skin muscle) cell cultures.	1992	Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12	(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties.
AID464181	Cytotoxicity against VSV infected HEL cells by trypan blue exclusion method	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID63597	Minimum inhibitory conc. for 50% inhibition of HSV-2 (Lyons) virus induced cytopathicity in E6SM cells	1997	Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9	Carbocyclic oxetanocins lacking the C-3' methylene.
AID1427827	Cytotoxicity against HEL cells infected with Varicella-Zoster virus assessed as alteration in cell morphology by microscopic method
AID85374	Inhibitory concentration against HSV type 1 strain Mc Intyre in human embryonic skin muscle (ESM) fibroblast cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID288940	Inhibition of proliferation of VZV thymidine kinase expressing OSTtk-/VZVtk+ -b cells	2007	Journal of medicinal chemistry, Jun-14, Volume: 50, Issue:12	5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
AID167887	Antiviral Activity against vesicular stomatitis virus in rabbit kidney cell	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID275071	Antiviral activity against Coxsackie B4 virus in HeLa cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID383531	Antiviral activity against Reo virus 1 in african green monkey Vero cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID217904	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against semliki forest virus in Vero cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID297312	Antiviral activity against VSV in HeLa cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID81898	The compound was tested for its antiviral activity against HSV-1 (KOS) virus in HEp-2M cell line	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID229235	Inhibitory activity against vesicular stomatitis virus (VSV) replication in E6SM cell cultures of human embryonic skin-muscle	2002	Journal of medicinal chemistry, Dec-05, Volume: 45, Issue:25	A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.
AID291036	Antiviral activity against Punta Toro virus in Vero cells assessed as reduction of virus plaque formation after 7 days	2007	Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13	Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
AID1684811	Selectivity index, ratio of CC50 for human HEL cells to EC50 for antiviral activity against thymidine kinase positive Varicella zoster virus OKA infected in human HEL cells	2021	ACS medicinal chemistry letters, Jan-14, Volume: 12, Issue:1	Influence of 4'-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2.
AID296679	Cytotoxicity against HEL cells after 3 days	2007	Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16	Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.
AID66942	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against vaccinia virus in E6SM cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID393982	Cytotoxicity against human HEL cells assessed as reduction of growth after 3 days	2009	Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6	4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus.
AID1410507	Antiviral activity against thymidine kinase deficient Varicella-Zoster virus 07-1 assessed as inhibition of plaque formation measured after 5 days post-infection	2018	ACS medicinal chemistry letters, Apr-12, Volume: 9, Issue:4	Amidate Prodrugs of Cyclic 9-(
AID1325061	Cytotoxicity against HEL cells assessed as alteration of cell morphology after 3 days by microscopic analysis	2016	Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21	First discovery of novel 3-hydroxy-quinazoline-2,4(1H,3H)-diones as specific anti-vaccinia and adenovirus agents via 'privileged scaffold' refining approach.
AID83897	Minimum inhibitory concentration required to reduce herpes simplex virus-1 (HSV-1 (McIntyre)) virus-induced cytopathicity by 50%	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID222129	Minimum concentration required to cause a microscopically detectable alteration of cell morphology	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID87194	Antiherpes activity was tested as percent of control of plaque-formation against HSV-1 (CL101) virus by 30 uM of the compound	1985	Journal of medicinal chemistry, Jul, Volume: 28, Issue:7	Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID156709	Evaluation for antiviral activity against vaccinia virus in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID90777	Antiviral activity against human cytomegalovirus Davis which reduces virus plaque formation by 50%; ND denotes no data	2002	Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19	Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles.
AID280193	Antiviral activity against VSV in HeLa cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID224696	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 100 mg/kg at day 9	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID482710	Cytotoxicity against human HeLa cells by MTT assay	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	"Viologen" dendrimers as antiviral agents: the effect of charge number and distance.
AID83044	Tested for cytotoxic activity in human embryonic lung fibroblast (HEL)	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID218513	Effective concentration required to reduce vesicular stomatitis virus (VSV)-induced cytopathicity in vero cells	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID65710	Antiviral activity against herpes simplex virus-1 TK-VMW 1837 (HSV-1) in E6SM cell cultures	2001	Journal of medicinal chemistry, Aug-02, Volume: 44, Issue:16	Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
AID167747	Antiviral Activity against herpes simplex virus-1 (McIntyre) in rabbit kidney cell	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID1230104	Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as reduction of virus-induced cytopathogenicity	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues.
AID81038	The compound was tested for cytotoxic concentration required to reduce human embryonic lung cell growth by 50%	1999	Journal of medicinal chemistry, Jul-15, Volume: 42, Issue:14	Novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis and biological evaluation.
AID1113471	Antiviral activity against Human herpesvirus 1 strain KOS infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID286286	Cytotoxicity against Kaposi's sarcoma-associated herpesvirus infected BC2 cells after 120 hrs by MTT assay	2007	Journal of medicinal chemistry, May-03, Volume: 50, Issue:9	9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus.
AID85828	Antiviral activity against herpes simplex virus type 1 (HSV-1) determined in baby hamster kidney cells	1983	Journal of medicinal chemistry, Sep, Volume: 26, Issue:9	Structural requirements of olefinic 5-substituted deoxyuridines for antiherpes activity.
AID516966	Antiviral activity against acyclovir-resistant HSV1 KOS infected in HEL assessed as reduction in virus-induce cytopathicity	2010	Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19	Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents.
AID297316	Antiviral activity against Vaccinia virus in HEL cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID216153	Effective concentration against TK+ Varicella-Zoster Virus (VZV) OKA strain	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID246311	Effective concentration required to reduce CMV AD169 strain virus plaque formation by 50% in HEL cell culture	2004	Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22	6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains.
AID291031	Cytotoxicity against HEL cells assessed as cell morphology after 7 days	2007	Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13	Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
AID1727355	Cytotoxicity against human HEL cells assessed as reduction in cell growth incubated for 3 days by coulter counter method	2021	European journal of medicinal chemistry, Jan-01, Volume: 209	Extension of furopyrimidine nucleosides with 5-alkynyl substituent: Synthesis, high fluorescence, and antiviral effect in the absence of free ribose hydroxyl groups.
AID217419	Proliferation of Vero cells by propagation on day 4 by measuring optical density (absorbance) at 100 ug/mL	1987	Journal of medicinal chemistry, Jul, Volume: 30, Issue:7	2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID429201	Cytotoxicity against human HEL cells assessed as microscopically detectable morphological alterations after 3 days	2009	European journal of medicinal chemistry, Aug, Volume: 44, Issue:8	Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl}guanine analogues.
AID81028	The compound was tested for antiviral activity by measuring the concentration required to reduce plaque formation against Varicella zoster TK+YS strain	1999	Journal of medicinal chemistry, Jul-15, Volume: 42, Issue:14	Novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis and biological evaluation.
AID63748	Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 2 (HSV-2) strain 196 induced cytopathogenicity by 50%.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID429202	Cytotoxicity against human HEL cells assessed as reduction in cell growth after 3 days	2009	European journal of medicinal chemistry, Aug, Volume: 44, Issue:8	Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl}guanine analogues.
AID221799	Compound was tested for antitumor activity against thymidine kinase deficient human B-lymphoblast Raji/0 cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID516962	Cytotoxicity against HEL assessed as change in cell morphology	2010	Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19	Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents.
AID84086	Minimum inhibitory concentration was determined against HSV-1 (G) in E6SM cell culture	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID81058	Concentration required to inhibit TK-VZV (YSR) induced cytopathogenicity in HEL cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID304888	Inhibition of VZV-TK catalyzed dThd phosphorylation	2007	Journal of medicinal chemistry, Dec-27, Volume: 50, Issue:26	Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines.
AID1337433	Antiviral activity against thymidine Kinase expressing Varicella-Zoster virus OKA infected in HEL cells assessed as inhibition of virus plaque formation	2016	European journal of medicinal chemistry, Nov-29, Volume: 124	Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor.
AID68252	Minimum inhibitory concentration required for antiviral activity to reduce HSV-1 (KOS) induced cytopathicity in human embryonic skin-muscle cells (ESM)	1994	Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9	Synthesis and antiviral activities of 8-alkynyl-, 8-alkenyl-, and 8-alkyl-2'-deoxyadenosine analogues.
AID85884	50% effective concentration required to reduce herpes simplex virus-2 (HSV-2 G strain)-induced cytopathicity	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID85378	Inhibitory concentration against HSV type 2 strain 196 in human embryonic skin muscle (ESM) fibroblast cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID607906	Antiviral activity against Herpes simplex virus 1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis	2011	Bioorganic & medicinal chemistry, Jul-15, Volume: 19, Issue:14	Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
AID87444	Concentration that induces 50% cell toxicity was determined using monolayers of uninfected HeLa cells	1985	Journal of medicinal chemistry, Jan, Volume: 28, Issue:1	Uridine 5'-diphosphate glucose analogues. Inhibitors of protein glycosylation that show antiviral activity.
AID83046	50% Minimum inhibitory concentration which is required to reduce cytopathogenicity induced by (G) strain of HSV-2 virus on human embryonic HEL cells.	1997	Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4	Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.
AID718735	Antiviral activity against Vesicular stomatitis virus infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities.
AID64105	Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-1( F) was measured	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID210698	Binding affinity towards HSV-1 thymidine kinase	1996	Journal of medicinal chemistry, Nov-22, Volume: 39, Issue:24	Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.
AID383509	Antiviral activity against respiratory syncytial virus in human HeLa cells assessed as inhibition of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID280197	Antiviral activity against parainfluenza3 virus in Vero cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID284539	Antiviral activity against Punta Toro virus-induced cytopathogenicity in Vero cells	2007	Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2	The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
AID246308	Effective concentration required to reduce HSV-2 strain G virus plaque formation by 50% in E6SM Cell Culture	2004	Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22	6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains.
AID224699	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 25 mg/kg at day 20	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID1782673	Antiviral activity against thymidine kinase deficient Varicella zoster virus	2021	European journal of medicinal chemistry, Aug-05, Volume: 220	Phenoxazine nucleoside derivatives with a multiple activity against RNA and DNA viruses.
AID303229	Antiviral activity against VSV in HeLa cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID658618	Antiviral activity against HSV2 G infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID45814	Dose that inhibited 50% cell growth of human T-lymphoid CEM cells compared with untreated control	2000	Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13	Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses.
AID83331	The minimum inhibitory concentration was measured on HEL cells against Varicella zoster virus (OKA strain)	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID1869612	Antiviral activity against VZV TK+ infected in HEL cells assessed as reduction in virus plaque formation	2022	Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13	Reshaping an Acyclic Nucleoside Phosphonate into a Selective Anti-hepatitis B Virus Compound.
AID218254	Evaluation for antiviral activity against parainfluenza-3 virus in Vero cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID85420	Compound was tested for antiviral activity against herpes simplex virus( HSV-2-lyons) strain in primary rabbit kidney cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID611617	Antiviral activity against Human herpesvirus 2 G infected in HEL cells assessed as protection against virus-induced cytopathicity	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	New prodrugs of Adefovir and Cidofovir.
AID1462034	Antiviral activity against wild type thymidine kinase expressing Varicella-Zoster virus Oka infected in HEL cells assessed as inhibition of virus-induced plaque formation	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID634751	Antiviral activity against Human cytomegalovirus AD169 infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID482704	Antiviral activity against Vaccina virus infected in human E6SM cell assessed as inhibition of virus-induced cytopathicity	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	"Viologen" dendrimers as antiviral agents: the effect of charge number and distance.
AID1337435	Antiviral activity against thymidine kinase deficient Varicella-Zoster virus YS-R infected in HEL cells assessed as inhibition of virus plaque formation	2016	European journal of medicinal chemistry, Nov-29, Volume: 124	Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor.
AID303236	Antiviral activity against Punta Toro virus in Vero cells reduction of virus-induced cytopathogenicity after 4 days	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID28488	Catalytic rate constant was determined; ND: Not determined	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID257890	Antiviral activity against Herpes simplex virus 2 G strain in HEL cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID245891	Cytotoxic concentration required to reduce HEL cell growth	2005	Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7	From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors.
AID85372	Inhibitory concentration against HSV type 1 strain F in human embryonic skin muscle (ESM) fibroblast cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID1427831	Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as reduction in virus-induced cytopathogenicity
AID68123	Concentration required to reduce vaccinia virus(VV) induced cytopathogenicity by 50% in ESM(embryonic skin muscle) cell cultures.	1992	Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12	(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties.
AID87842	Effect on thymidine kinase in the herpes simplex type-1 infected cells	1985	Journal of medicinal chemistry, Jun, Volume: 28, Issue:6	Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents.
AID434306	Cytotoxicity against human HeLa cells assessed as change in cell morphology	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID217760	Cytotoxicity was measured by determining the incorporation of [methyl-3H]thymidine into DNA of Vero cells	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Synthesis and antiviral properties of 5-(2-substituted vinyl)-6-aza-2'-deoxyuridines.
AID607912	Cytotoxicity against cat CRFK cells by colorimetric formazan-based MTS assay	2011	Bioorganic & medicinal chemistry, Jul-15, Volume: 19, Issue:14	Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
AID63762	The minimum inhibitory concentration was measured on E6SM cells against Herpes simplex virus type 2 (G strain)	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID216408	Antiviral activity against vesicular stomatitis virus	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID1113470	Cytotoxicity against Homo sapiens (human) HEL cells assessed as change in cellular morphology	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID64109	Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-2 (Lyons) was measured.	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID246414	Concentration required to inhibit herpes simplex virus type 1 induced cytopathogenicity in HEL cells by 50%	2005	Journal of medicinal chemistry, Jul-14, Volume: 48, Issue:14	Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.
AID84950	Ability to reduce plaque formation of herpes simplex virus type 2 (HSV-2) by 50% in human embryonic lung fibroblast (HELF) cell cultures	1988	Journal of medicinal chemistry, Feb, Volume: 31, Issue:2	Synthesis and biological activities of 4-O-(difluoromethyl)-5-substituted-uracil nucleoside analogues.
AID303224	Cytotoxicity against HEL cells assessed as cell growth after 3 days	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID63948	Tested for minimum cytotoxic concentration on virus-induced cytopathicity in E6SM cells	1993	Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20	Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents.
AID85720	Concentration required to reduce HSV-1 virus induced cytopathogenicity in rabbit cell kidney culture (McIntyre cells)	1988	Journal of medicinal chemistry, Jan, Volume: 31, Issue:1	Synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2'-deoxycytidine-related compounds.
AID1498113	Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathicity	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.
AID1869613	Antiviral activity against VZV TK- infected in HEL cells assessed as reduction in virus plaque formation	2022	Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13	Reshaping an Acyclic Nucleoside Phosphonate into a Selective Anti-hepatitis B Virus Compound.
AID611621	Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as protection against virus-induced cytopathicity	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	New prodrugs of Adefovir and Cidofovir.
AID221320	Evaluated for the minimum inhibitory concentration (MIC) in primary rabbit kidney (PRK) by 50% against herpes simplex virus type-1 (HSV-1) with strains McIntyre	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID1409614	Overall antiviral activity against SARS-CoV-2 (isolate France/IDF0372/2020) in the Vero E6 cell line at 48 h based on three assays 1) detection of viral RNA by qRT-PCR (targeting the N-gene), 2) plaque assay using lysate 3 days after addition of compound	2020	Nature, 07, Volume: 583, Issue:7816	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
AID1661191	Cytotoxicity against human HEL cells assessed as minimum cytotoxic concentration for change in cellular morphology incubated for 3 days by microscopic analysis	2020	ACS medicinal chemistry letters, Jul-09, Volume: 11, Issue:7	Amidate Prodrugs of
AID165784	Inhibitory activity against Raji cell line	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID216346	Tested for antiviral activity against Punta toro virus in African green monkey kidney cell (Vero)	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID416775	Antiviral activity against Vaccinia virus Lederle in human HEL cells assessed as protection against virus-induced cytopathicity	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID217806	Evaluated for the anti-VZV, the concentration of compounds in uM required to reduce VZVTK-YS-R ( thymidine kinase-deficient strain ) plaque formation after 5 days in HEL cell cultures compared to untreated controls.	2000	Journal of medicinal chemistry, Dec-28, Volume: 43, Issue:26	Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain.
AID303233	Antiviral activity against Parainfluenza 3 in Vero cells reduction of virus-induced cytopathogenicity after 4 days	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID63602	Minimum inhibitory concentration required to effect a microscopically visible change of cell morphology in human embryonic skin-muscle (E6SM) cell culture.	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID216303	Compound was evaluated for the inhibition of VZV strains of YS	1999	Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22	Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base.
AID217659	Evaluated for the anti-VZV activity, the concentration of compounds in uM required to reduce VZV OKA Plaque formation after 5 days in HEL cell cultures compared to untreated controls.	2000	Journal of medicinal chemistry, Dec-28, Volume: 43, Issue:26	Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain.
AID687661	Antiviral activity against HSV1 KOS infected in HEL assessed as inhibition of virus-induced cytopathicity after 3 days	2012	European journal of medicinal chemistry, Nov, Volume: 57	Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4'-phosphono-but-2'-en-1'-yl]purine nucleosides.
AID246626	Effective concentration required to inhibit human cytomegalo virus AD-169 induced cytopathicity in HEL fibroblast cell line after 7 days of postinfection	2005	Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7	From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors.
AID217510	Minimum inhibitory concentration required to reduce Varicella-Zoster virus (VZV (Oka)) virus-induced cytopathicity by 50%	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID246470	Effective concentration required to reduce Varicella-Zoster virus OKA(TK) plaque formation after 5 days in HEL fibroblast cell line	2005	Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7	From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors.
AID463991	Antiviral activity against Vaccinia virus infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID1394851	Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as inhibition of plaque formation measured after 2 to 3 days post infection	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates.
AID246532	Concentration required to inhibit human immunodeficiency virus-1 (strain IIIb) induced cytopathogenicity in CEM cells by 50%	2005	Journal of medicinal chemistry, Jul-14, Volume: 48, Issue:14	Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.
AID84762	Antiviral activity against Herpes Simplex Virus-2(Lyons)	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID217503	cytostatic concentration required to reduce the HEL cell number by 50%. after 5 days in the absence of virus	2000	Journal of medicinal chemistry, Dec-28, Volume: 43, Issue:26	Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain.
AID90775	Antiviral activity against human cytomegalovirus AD-169 which reduces virus plaque formation by 50%; ND denotes no data	2002	Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19	Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles.
AID111521	Tested for the appearance of skin lesions or paralysis of the legs after 39 days when administered intraperitoneally at 100 mg/kg per day	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID687663	Antiviral activity against acyclovir-resistant thymidine kinase deficient HSV1 KOS infected in HEL assessed as inhibition of virus-induced cytopathicity after 3 days	2012	European journal of medicinal chemistry, Nov, Volume: 57	Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4'-phosphono-but-2'-en-1'-yl]purine nucleosides.
AID216539	Evaluation of antiviral activity against Vesicular stomatitis virus.	1986	Journal of medicinal chemistry, Jul, Volume: 29, Issue:7	Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID387854	Cytotoxicity against HEL cells assessed as alteration in cell morphology by MTS assay	2008	Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18	Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure.
AID280195	Antiviral activity against coxsackie B4 virus in Vero cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID244773	Minimum cytotoxic concentration required to cause a microscopically visible alteration of HEL fibroblast cell morphology	2005	Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7	From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors.
AID218374	Inhibitory dose required to reduce the growth of vero cells by 50% over a 4 day period.	1996	Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3	Synthesis and anti-herpes virus activity of 2'-deoxy-4'-thiopyrimidine nucleosides.
AID87843	Antiviral activity against herpes simplex type-1 expressed as ED50	1985	Journal of medicinal chemistry, Jun, Volume: 28, Issue:6	Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents.
AID85883	50% effective concentration required to reduce herpes simplex virus-1 (HSV-1 KOS strain)-induced cytopathicity	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID383532	Antiviral activity against Sindbis virus in african green monkey Vero cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID84760	Antiviral activity against Herpes Simplex Virus-2(196)	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID217483	Inhibitory concentration against VSV in human embryonic skin muscle (ESM) fibroblast cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID482709	Cytotoxicity against human E6SM cells by MTT assay	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	"Viologen" dendrimers as antiviral agents: the effect of charge number and distance.
AID87827	Evaluation of antiviral activity against Herpes simplex virus type 2 (HSV-2) strain G	1986	Journal of medicinal chemistry, Jul, Volume: 29, Issue:7	Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID85120	Inhibitory activity against HSV-2 (G) replication in E6SM cell cultures of human embryonic skin-muscle	2002	Journal of medicinal chemistry, Dec-05, Volume: 45, Issue:25	A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.
AID634831	Antiviral activity against Respiratory syncytial virus infected in human HeLa cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID216302	Compound was evaluated for the inhibition of VZV strains of OKA	1999	Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22	Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base.
AID218511	Effective concentration required to reduce reovirus-1-induced cytopathicity in vero cells	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID83052	50% Minimum inhibitory concentration which is required to reduce cytopathogenicity induced by TK-(B2006) strain of HSV-1 virus on human embryonic HEL cells.	1997	Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4	Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.
AID304886	Cytotoxicity against HEL cells assessed as alteration in cell morphology	2007	Journal of medicinal chemistry, Dec-27, Volume: 50, Issue:26	Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines.
AID1394845	Antiviral activity against thymidine kinase deficient Varicella-Zoster virus 07-1 infected in HEL cells assessed as inhibition of plaque formation measured after 5 days post infection	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates.
AID1652588	Cytotoxicity in human CEM/0 cells assessed as reduction in cell viability incubated for 4 to 5 days
AID221325	Evaluated for the minimum inhibitory concentration (MIC) in primary rabbit kidney (PRK) by 50% against herpes simplex virus type-2 (HSV-2) with strains 196	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID1382164	Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as reduction in viral cytopathic effect	2018	European journal of medicinal chemistry, Feb-25, Volume: 146	Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.
AID675222	Cytotoxicity against HEL cells assessed as effect on cell growth incubated for 3 days by Coulter counter assay	2012	European journal of medicinal chemistry, Sep, Volume: 55	Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
AID297319	Antiviral activity against Sindbis virus in Vero cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID1382169	Selectivity index, ratio of CC50 for HEL cells to EC50 for Varicella zoster virus Oka infected in HEL cells	2018	European journal of medicinal chemistry, Feb-25, Volume: 146	Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.
AID1462040	Cytotoxicity against HEL cells assessed as reduction in cell growth after 3 days by coulter counter method	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID297315	Antiviral activity against HSV2 G in HEL cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID81056	Concentration required to inhibit TK-VZV (07-1) induced cytopathogenicity in HEL cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID288916	Antiviral activity against HSV1 KOS in E6SM cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Jun-14, Volume: 50, Issue:12	5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
AID553337	Antiviral activity against HSV1 KOS infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days	2011	Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1	Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.
AID607916	Antiviral activity against thymidine kinase-deficient Varicella-zoster virus YS/R infected in human HEL cells assessed as reduction in the virus plaque formation	2011	Bioorganic & medicinal chemistry, Jul-15, Volume: 19, Issue:14	Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
AID221967	Compound was tested for antitumor activity against human T-lymphoblast Molt/4F cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID280205	Cytotoxicity against Vero cells assessed as alteration in cell morphology	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID1410503	Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect measured after 2 to 3 days post-infection	2018	ACS medicinal chemistry letters, Apr-12, Volume: 9, Issue:4	Amidate Prodrugs of Cyclic 9-(
AID217657	Minimum inhibitory concentration was determined against VZV (YS) in HEL cells	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID217508	Inhibition of viral cytopathic effect in infected human foreskin fibroblast cell in monolayers of VZV Ellen Vero cells by 50%	2001	Journal of medicinal chemistry, Oct-11, Volume: 44, Issue:21	Synthesis and antiviral activity of novel 5-(1-cyanamido-2-haloethyl) and 5-(1-hydroxy(or methoxy)-2-azidoethyl) analogues of uracil nucleosides.
AID607908	Antiviral activity against Feline herpesvirus infected in cat CRFK cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis	2011	Bioorganic & medicinal chemistry, Jul-15, Volume: 19, Issue:14	Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
AID216347	Tested for antiviral activity against Reo-1 virus in African green monkey kidney cell (Vero)	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID280179	Antiviral activity against VZV OKA in HEL cells assessed as inhibition of plaque formation	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID245943	Concentration required to inhibit cell proliferation in HEL cells by 50%	2005	Journal of medicinal chemistry, Jul-14, Volume: 48, Issue:14	Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.
AID87984	Minimum inhibitory concentration which is active against herpes simplex virus type-1 (HSV-1); value ranges from 0.007-0.01 ug/mL	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and antiviral activity of 3'-deoxy-3'-C-hydroxymethyl nucleosides.
AID217829	Concentration required to reduce cytopathogenicity of vaccinia virus by 50% in primary rabbit kidney (PRK) cells	1984	Journal of medicinal chemistry, Nov, Volume: 27, Issue:11	Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID83182	Concentration required to reduce VZV-YS/R-TK- plaque formation by 50% in human embryonic lung (HEL) cell cultures.	1992	Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12	(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties.
AID284535	Cytotoxicity against E6SM cells	2007	Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2	The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
AID257901	Antiviral activity against Vesicular stomatitis virus in HeLa cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID388919	Antiviral activity against thymidine kinase deficient Varicella-Zoster virus 07/1 in HEL cells assessed as inhibition of viral cytopathicity	2008	Bioorganic & medicinal chemistry, Nov-01, Volume: 16, Issue:21	Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): part II.
AID569234	Antiviral activity against VZV OKA expressing thymidine kinase infected in HEL cells assessed as inhibition of plaque formation	2011	European journal of medicinal chemistry, Feb, Volume: 46, Issue:2	Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation.
AID1610166	Antiviral activity against Vaccinia virus infected in human HELF cells assessed as reduction in virus-induced cytopathogenicity incubated for 7 days by microscopic analysis	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID258991	Antiviral activity against Varicella-Zoster virus YS/R strain	2006	Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1	Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivatives.
AID768204	Antiviral activity against Herpes simplex virus-1 KOS infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID217484	Minimal inhibitory concentration to reduce virus-induced cytopathicity against VSV	2001	Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24	Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study.
AID297314	Antiviral activity against HSV1 KOS in HEL cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID66780	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 1 ug/mL of dUrd	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID464180	Cytotoxicity against Vaccinia virus infected HEL cells by trypan blue exclusion method	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID634833	Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID1409607	IC50 for antiviral activity against SARS-CoV-2 in the Vero E6 cell line at 48 h by immunofluorescence-based assay (detecting the viral NP protein in the nucleus of the Vero E6 cells).	2020	Nature, 07, Volume: 583, Issue:7816	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
AID548425	Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID63598	Minimum inhibitory conc. for 50% inhibition of TK HSV-1 (B2006) virus induced cytopathicity in E6SM cells	1997	Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9	Carbocyclic oxetanocins lacking the C-3' methylene.
AID224704	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 250 mg/kg at day 12	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID66002	50% Minimum inhibitory concentration which is required to reduce cytopathogenicity induced by (F) strain of HSV-1 virus on human E6SM cells.	1997	Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4	Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.
AID209374	Evaluated for the minimum inhibitory concentration (MIC) in primary rabbit kidney (PRK) by 50% against TK- herpes simplex virus type 1 (TK- HSV-1) with strain VMW 1837	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID235596	Ratio of ID50/ID90 in HSV-2 infected cells	1985	Journal of medicinal chemistry, Jun, Volume: 28, Issue:6	Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents.
AID63593	Minimum inhibitory conc. for 50% inhibition of HSV-1 (McIntyre) virus induced cytopathicity in E6SM cells	1997	Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9	Carbocyclic oxetanocins lacking the C-3' methylene.
AID87299	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in HeLa cell culture by 50% in presence of specified concentrations of 6-aminothymine	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID309814	Cytotoxicity against HEL cells assessed as alteration in cell morphology after 3 days	2007	Bioorganic & medicinal chemistry, Nov-15, Volume: 15, Issue:22	Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV).
AID82551	Tested for the cytotoxic concentration, required to reduce cell growth by 50% in human embryonic lung (HEL) cells.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID280200	Antiviral activity against punta toro virus in Vero cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID83526	Anti-VZV activity against YS TK+ in HEL cells	1998	Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25	Synthesis of imidazo[1,2-a]pyridines as antiviral agents.
AID63760	The minimum inhibitory concentration was measured on E6SM cells against Herpes simplex virus type 1 (McIntyre strain)	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID87821	Antiviral activity expressed as minimum HSV-2 (Lyons) strain-induced cytopathogenicity in primary rabbit kidney cell cultures	1981	Journal of medicinal chemistry, Jun, Volume: 24, Issue:6	Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID280192	Antiviral activity against VSV in E6SM cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID1230099	Cytotoxicity against HEL cells assessed as alternation of cell morphology by microscopic analysis	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues.
AID66775	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in absence of dUrd	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID718734	Antiviral activity against thymidine kinase deficient and acyclovir-resistant HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities.
AID66938	Cytotoxicity concentration required to microscopically detectable alteration of cell morphology in E6SM	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID66773	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in absence of Urd	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID1328757	Cytostatic activity against thymidine kinase deficient human CD4-positive CEM cells after 3 days by cell counting method	2016	Bioorganic & medicinal chemistry letters, 12-01, Volume: 26, Issue:23	ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites.
AID165527	Concentration required to reduce Herpes simplex virus type 2 induced cytopathogenicity in primary rabbit kidney (PRK) cell cultures	1983	Journal of medicinal chemistry, May, Volume: 26, Issue:5	Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.
AID167137	Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against HSV-2 (G)	1983	Journal of medicinal chemistry, Apr, Volume: 26, Issue:4	Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID658741	Cytotoxicity against human HEL cells assessed as minimum compound concentration required to causes microscopically detectable alteration of normal cell morphology	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID303212	Antiviral activity against HSV2 G in HEL cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID280189	Antiviral activity against HIV1 3B in human CEM cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID81024	The compound was tested for anti CMV (Cytomegalovirus- virus) activity against AD-169 strain in HEL cells;d ='not determined'	1998	Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25	Synthesis of imidazo[1,2-a]pyridines as antiviral agents.
AID383510	Cytotoxicity against human E6SM cells	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID83198	Minimum inhibitory concentration required for antiviral activity to reduce TK Varicella Zoster virus (VZV) (07/1) induced cytopathicity in human embryonic lung cells (HEL)	1994	Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9	Synthesis and antiviral activities of 8-alkynyl-, 8-alkenyl-, and 8-alkyl-2'-deoxyadenosine analogues.
AID658755	Antiviral activity against VSV OKA expressing thymidine kinase infected in HEL cells assessed as reduction of virus plaque formation after 4 days	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID303209	Antiviral activity against HSV1 KOS in HEL cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID85418	Compound was tested for antiviral activity against herpes simplex virus( HSV-2-196 strain in primary rabbit kidney cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID63599	Minimum inhibitory conc. for 50% inhibition of alteration of morphology in E6SM cells	1997	Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9	Carbocyclic oxetanocins lacking the C-3' methylene.
AID66767	The compound was tested for its antiviral activity against HSV-2 (196) virus in E6SM cell culture	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID63757	The compound was tested for antiviral activity against thymidine kinase-deficient (TK-HSV-1)virus in E6SM cell line(human embryonic skin-muscle fibroblasts)	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID161457	Antiviral activity against McIntyre strain of herpes simplex virus-1 in primary rabbit kidney cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID84766	Antiviral activity against Herpes Simplex Virus-2(Lyons)	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis and antitumor and antiviral properties of 5-alkyl-2'-deoxyuridines, 3',5'-cyclic monophosphates, and neutral cyclic triesters.
AID482715	Cytotoxicity against african green monkey Vero cells by MTT assay	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	"Viologen" dendrimers as antiviral agents: the effect of charge number and distance.
AID393979	Antiviral activity against thymidine kinase expressing Varicella zoster virus Oka infected in human HEL cells assessed reduction in viral plaque formation	2009	Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6	4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus.
AID432169	Cytotoxicity against HEL cells assessed as minimum cytotoxic concentration required to cause microscopically detectable alteration in normal cell morphology	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID665385	Antiviral activity against thymidine kinase-deficient Varicella-zoster virus 07/1 infected in HEL cells assessed as reduction in virus-induced cytopathicity	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and antiviral evaluation of C5-substituted-(1,3-diyne)-2'-deoxyuridines.
AID167877	Antiviral Activity against herpes simplex virus-1 TK- B2006 in rabbit kidney cell	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID85714	Antiviral activity against Herpes Simplex Virus-1 (McIntyre)	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID569238	Antiviral activity against Vaccinia virus infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2011	European journal of medicinal chemistry, Feb, Volume: 46, Issue:2	Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation.
AID68256	Minimum inhibitory concentration required for antiviral activity to reduce Vesicular stomatitis virus (VSV) induced cytopathicity in human embryonic skin-muscle cells (ESM)	1994	Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9	Synthesis and antiviral activities of 8-alkynyl-, 8-alkenyl-, and 8-alkyl-2'-deoxyadenosine analogues.
AID246314	Concentration required to inhibit vaccinia virus induced cytopathogenicity in HEL cells by 50%	2005	Journal of medicinal chemistry, Jul-14, Volume: 48, Issue:14	Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.
AID291030	Antiviral activity against thymidine kinase deficient Varicella-Zoster virus 07/1 assessed as reduction of plaque formation	2007	Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13	Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
AID548423	Cytotoxicity against human HEL cells assessed as altered cell morphology	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID304887	Cytotoxicity against HEL cells	2007	Journal of medicinal chemistry, Dec-27, Volume: 50, Issue:26	Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines.
AID221326	Evaluated for the minimum inhibitory concentration (MIC) in primary rabbit kidney (PRK) by 50% against herpes simplex virus type-2 (HSV-2) with strains G	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID1727353	Antiviral activity against thymidine kinase deficient Varicella zoster virus 07-1 infected in human HEL cells assessed as reduction in virus-induced cytopathogenic effect measured after 3 days coulter counter method	2021	European journal of medicinal chemistry, Jan-01, Volume: 209	Extension of furopyrimidine nucleosides with 5-alkynyl substituent: Synthesis, high fluorescence, and antiviral effect in the absence of free ribose hydroxyl groups.
AID63765	The minimum inhibitory concentration was measured on E6SM cells against TK-Herpes simplex virus type 1 (B2006 strain)	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID83022	Tested for the inhibitory concentration required to reduce cytomegalovirus (CMV) strain Davis plaque formation by 50%.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID284540	Antiviral activity against in Vesicular stomatitis virus- induced cytopathogenicity in HeLa cells	2007	Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2	The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
AID217674	Inhibitory concentration against VZV strain YS in human embryonic lung (HEL) cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID383515	Antiviral activity against HSV2 G in human HEL cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID112441	Inhibitory activity against incorporation of deoxy-[methyl.3H-]-thymidine (dThd) into the DNA of murine leukemia L1210 cell cultures	1983	Journal of medicinal chemistry, May, Volume: 26, Issue:5	Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.
AID1457768	Antiviral activity against thymidine kinase deficient Varicella-Zoster virus 07-1 infected in HEL cells assessed as inhibition of plaque formation	2017	Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14	Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
AID1782676	Cytotoxicity against human HEL cells assessed as reduction in cell viability measured after 3 days by beckman coulter counting method	2021	European journal of medicinal chemistry, Aug-05, Volume: 220	Phenoxazine nucleoside derivatives with a multiple activity against RNA and DNA viruses.
AID392511	Antiviral activity against Herpes simplex virus 1	2009	Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2	Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
AID66003	50% Minimum inhibitory concentration which is required to reduce cytopathogenicity induced by (G) strain of HSV-2 virus on human E6SM cells.	1997	Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4	Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.
AID84243	Minimum inhibitory concentration was determined against HSV-1 (TK-KOS ACV) in E6SM cell culture	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID86492	Tested for antiviral activity against coxsackie-B4 virus in human epithelial cell line	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID634756	Antiviral activity against Reovirus-1 infected in african green monkey Vero cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID607919	Cytotoxicity against human HEL cells by colorimetric formazan-based MTS assay	2011	Bioorganic & medicinal chemistry, Jul-15, Volume: 19, Issue:14	Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
AID1684815	Antiviral activity against Human cytomegalovirus AD169 infected in human HEL cells assessed as reduction in virus plaque formation measured on day 6 to 7 post-viral infection	2021	ACS medicinal chemistry letters, Jan-14, Volume: 12, Issue:1	Influence of 4'-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2.
AID84604	Concentration required to reduce cytopathogenicity of Herpes simplex virus type 2 (strain G) by 50% in primary rabbit kidney (PRK) cells	1984	Journal of medicinal chemistry, Nov, Volume: 27, Issue:11	Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID85112	Inhibitory activity against HSV-2 (196) replication in E6SM cell cultures of human embryonic skin-muscle	2002	Journal of medicinal chemistry, Dec-05, Volume: 45, Issue:25	A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.
AID72044	Inhibitory activity against FM3A/0 cell line	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID1251997	Cytotoxicity against Varicella zoster virus infected HEL cells assessed as alteration of cell morphology incubated for 3 days by microscopy	2015	Bioorganic & medicinal chemistry, Nov-01, Volume: 23, Issue:21	Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides.
AID66020	Compound was evaluated for the minimum inhibition concentration required to reduce virus-induced cytopathogenicity by 50%, determined against KOS,F,McIntyre strains of HSV-1 virus.	1998	Journal of medicinal chemistry, Oct-22, Volume: 41, Issue:22	5-Substituted pyrimidines with a 1,5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase.
AID383523	Antiviral activity against Coxsackie virus B4 in african green monkey Vero cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID216533	Evaluated for the minimum inhibitory concentration (MIC) in primary rabbit kidney (PRK) by 50% against vesicular stomatitis virus	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID85402	Antiviral activity against HSV-1 kinase mutant resistant to B3(BVdU) was determined at a conc of 30 uM	1987	Journal of medicinal chemistry, Nov, Volume: 30, Issue:11	Acetylenic nucleosides. 4. 1-beta-D-arabinofuranosyl-5-ethynylcytosine. Improved synthesis and evaluation of biochemical and antiviral properties.
AID85379	Inhibitory concentration against HSV type 2 strain G in human embryonic skin muscle (ESM) fibroblast cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID85421	Minimal inhibitory concentration to reduce virus-induced cytopathicity against 196 strain of human Herpes Simplex Virus-2	2001	Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24	Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study.
AID85407	Antiviral activity against HSV-1 kinase mutant resistant to Tr7(ACV) was determined at a conc of 30 uM	1987	Journal of medicinal chemistry, Nov, Volume: 30, Issue:11	Acetylenic nucleosides. 4. 1-beta-D-arabinofuranosyl-5-ethynylcytosine. Improved synthesis and evaluation of biochemical and antiviral properties.
AID482711	Antiviral activity against Parainfluenza virus 3 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathicity	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	"Viologen" dendrimers as antiviral agents: the effect of charge number and distance.
AID718736	Antiviral activity against Vaccinia virus infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities.
AID106002	Inhibitory activity against human cytomegalovirus (HCMV) strain AD169 in MRC-5 cells.	1996	Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3	Synthesis and anti-herpes virus activity of 2'-deoxy-4'-thiopyrimidine nucleosides.
AID167746	Antiviral Activity against herpes simplex virus-1 (KOS) in rabbit kidney cell	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID120302	In vivo evaluation for the percent survivors in systemic HSV-1 infection of Mice administered through oral route at a dose 2.5 mg/kg per day	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID83195	Minimum inhibitory conc. for 50% inhibition of growth in HEL cells	1997	Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9	Carbocyclic oxetanocins lacking the C-3' methylene.
AID63607	Tested for antiviral activity against thymidine kinase-deficient (TK-HSV-2G) virus in E6SM cell line(human embryonic skin-muscle fibroblasts)	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID1710792	Antiviral activity against Vaccinia virus infected in human HEL cells assessed as reduction in virus-induced cytopathic effect incubated for 3 to 6 days by light microscopic analysis	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	Synthesis and antiviral properties of novel indole-based thiosemicarbazides and 4-thiazolidinones.
AID63591	Minimum inhibitory conc. for 50% inhibition of HSV-1 (F) virus induced cytopathicity in E6SM cells	1997	Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9	Carbocyclic oxetanocins lacking the C-3' methylene.
AID675216	Antiviral activity against thymidine kinase negative and ACV resistant HSV1 KOS infected in HEL cells by viral CPE assay	2012	European journal of medicinal chemistry, Sep, Volume: 55	Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
AID66777	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 1 ug/mL dThd	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID216509	The compound was tested for its antiviral activity against HSV-1 (KOS) virus in vero cell line	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID81025	The compound was tested for anti CMV (Cytomegalovirus- virus) activity against Davis strain in HEL cells;d ='not determined'	1998	Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25	Synthesis of imidazo[1,2-a]pyridines as antiviral agents.
AID387602	Cytotoxicity against human HeLa cells assessed as alteration in cell morphology by MTS assay	2008	Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18	Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure.
AID416772	Cytotoxicity against human HEL cells assessed as drug level causing microscopically detectable alteration of normal cell morphology after 3 days	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID167139	Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against Vaccinia virus	1983	Journal of medicinal chemistry, Apr, Volume: 26, Issue:4	Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID156702	Evaluation for antiviral activity against herpes simplex virus-1(F) in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID1610151	Antiviral activity against thymidine kinase deficient Varicella zoster virus infected in human HELF cells assessed as reduction in virus-induced cytopathogenicity incubated for 7 days by Giemsa staining based microscopic analysis	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID64120	Tested for minimum inhibitory concentration against Vaccinia virus in E6SM cells	1993	Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20	Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents.
AID463993	Antiviral activity against acyclovir-sensitive Herpes simplex virus 1 KOS infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID87993	Effect on thymidine kinase in the herpes simplex type-2 infected cells	1985	Journal of medicinal chemistry, Jun, Volume: 28, Issue:6	Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents.
AID87153	Evaluated for minimum inhibitory concentration against HeLa cells (human carcinoma) infected with VSV, Coxs, B4, polio-1 virus	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one.
AID66934	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of specified concentrations of benzylacyclouridine	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID303221	Cytotoxicity against HEL cells assessed as alteration in morphology after 3 days	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID167135	Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against HSV-1 (McIntyre)	1983	Journal of medicinal chemistry, Apr, Volume: 26, Issue:4	Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID1410506	Antiviral activity against thymidine kinase expressing Varicella-Zoster virus Oka assessed as inhibition of plaque formation measured after 5 days post-infection	2018	ACS medicinal chemistry letters, Apr-12, Volume: 9, Issue:4	Amidate Prodrugs of Cyclic 9-(
AID217888	Antiviral activity against HSV-1 (Brand) in Vero cells	1987	Journal of medicinal chemistry, Jul, Volume: 30, Issue:7	2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID434313	Antiviral activity against Coxsackievirus B4 infected in human HeLa cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID64089	Concentration required to inhibit HSV-2(lyons) induced cytopathogenicity in E6SM cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID66006	50% Minimum inhibitory concentration which is required to reduce cytopathogenicity induced by (Mc Intyre) strain of HSV-1 virus on human E6SM cells.	1997	Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4	Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.
AID134101	Topical treatment of intracutaneous TK- herpes simplex virus type 1 of strain VMW 1837 infection of Nu/nu mice for mean day of appearance of skin lesions and/or paralysis of the hind legs at 3% concentration (v/v in DMSO)	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID1382163	Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as reduction in viral cytopathic effect	2018	European journal of medicinal chemistry, Feb-25, Volume: 146	Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.
AID64087	Concentration required to inhibit HSV-2(196) induced cytopathogenicity in E6SM cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID280176	Antiviral activity against ACV-resistant TK- HSV1 KOS in HEL cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID658617	Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID1610154	Cytotoxicity against human HELF cells assessed as reduction in cell viability incubated for 3 days by coulter counter method	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID1337442	Cytotoxicity against HEL cells assessed as alteration of cell morphology after 3 days by microscopic method	2016	European journal of medicinal chemistry, Nov-29, Volume: 124	Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor.
AID217758	In vitro antiviral activity against HSV-2(strain 196) in Vero cells	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Synthesis and antiviral properties of 5-(2-substituted vinyl)-6-aza-2'-deoxyuridines.
AID1661189	Antiviral activity against thymidine kinase positive Varicella zoster virus OKA infected in human HEL cells assessed as reduction in plaque formation measured after 5 days	2020	ACS medicinal chemistry letters, Jul-09, Volume: 11, Issue:7	Amidate Prodrugs of
AID1652585	Antiviral activity against HIV1 3B infected in human CEM/0 cells assessed as inhibition of viral-induced giant cell formation incubated for 4 to 5 days by microscopy
AID296678	Cytotoxicity against HEL cells assessed as alteration in cell morphology after 3 days	2007	Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16	Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.
AID634754	Antiviral activity against thymidine kinase-deficient Varicella Zoster virus 07/1 infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID539918	Antiviral activity against Vesicular stomatitis virus infected in human HEL cells assessed as protection against virus-induced cytopathogenicity after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID1462031	Antiviral activity against wild type Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID63604	Tested for antiviral activity against VSV-virus in human embryonic skin muscle fibroblasts	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID553336	Cytotoxicity against human HEL cells after 3 days	2011	Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1	Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.
AID309812	Antiviral activity against HCMV AD169 in HEL cells assessed as reduction of virus plaque formation after 5 days	2007	Bioorganic & medicinal chemistry, Nov-15, Volume: 15, Issue:22	Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV).
AID120296	In vivo evaluation for the percent survivors in systemic HSV-1 infection of Mice administered through intraperitoneal at a dose 1 mg/kg per day	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID217889	Antiviral activity against HSV-2 (K979) in Vero cells	1987	Journal of medicinal chemistry, Jul, Volume: 30, Issue:7	2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID463990	Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID463992	Antiviral activity against VSV infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 1 to 2 days by MTT assay	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID221319	Evaluated for the minimum inhibitory concentration (MIC) in primary rabbit kidney (PRK) by 50% against herpes simplex virus type-1 (HSV-1) with strains KOS	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID280191	Antiviral activity against MSV in mouse C3H cells assessed as inhibition of virus-induced transformation after 6 days	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID83329	The minimum inhibitory concentration was measured on HEL cells against TK-Varicella zoster virus (YS-R strain)	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID84217	Inhibitory activity against HSV-1 (KOS) replication in E6SM cell cultures of human embryonic skin-muscle	2002	Journal of medicinal chemistry, Dec-05, Volume: 45, Issue:25	A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.
AID83194	Minimum inhibitory conc. for 50% inhibition of VZV (YS) virus plaque formation in HEL cells	1997	Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9	Carbocyclic oxetanocins lacking the C-3' methylene.
AID634838	Antiviral activity against Human immunodeficiency virus 1 infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopic analysis	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID81191	Concentration required to inhibit VZV (oka) induced cytopathogenicity in HEL cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID85556	Antiviral activity against various strains of Herpes Simplex virus type I	1982	Journal of medicinal chemistry, Nov, Volume: 25, Issue:11	Synthesis and antiviral properties of some 2'-deoxy-5-(fluoroalkenyl)uridines.
AID232770	Selectivity index against HSV-1 was determined as CD50/ED50 ratio	1994	Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1	S-glucosylated hydantoins as new antiviral agents.
AID766700	Antiviral activity against Herpes simplex virus-1 KOS infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID1422441	Antiviral activity against Vaccinia virus infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by microscopic method	2018	Bioorganic & medicinal chemistry letters, 11-15, Volume: 28, Issue:21	Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents.
AID83197	Minimum inhibitory concentration required for antiviral activity to reduce Cytomegalovirus (CMV) (Davis) induced cytopathicity in human embryonic lung cells (HEL)	1994	Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9	Synthesis and antiviral activities of 8-alkynyl-, 8-alkenyl-, and 8-alkyl-2'-deoxyadenosine analogues.
AID87828	Evaluation of antiviral activity against Herpes simplex virus type 2 (HSV-2) strain Lyons	1986	Journal of medicinal chemistry, Jul, Volume: 29, Issue:7	Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID66781	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 1 ug/mL of dUrd and 50 ug/mL of 6-aminothymine	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID288918	Antiviral activity against Vaccinia virus in E6SM cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Jun-14, Volume: 50, Issue:12	5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
AID284529	Antiviral activity against Vaccinia virus-induced cytopathogenicity in E6SM cells	2007	Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2	The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
AID217421	Proliferation of Vero cells by propagation on day 4 by measuring optical density (absorbance) at 330 ug/mL	1987	Journal of medicinal chemistry, Jul, Volume: 30, Issue:7	2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID1610163	Antiviral activity against Herpes simplex virus 1 KOS infected in human HELF cells assessed as reduction in virus-induced cytopathogenicity incubated for 7 days by microscopic analysis	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID210688	Binding affinity constant against HSV-1 thymidine kinase	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID72045	Compound was tested for antitumor activity against FM3A/0 mammary carcinoma cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID607915	Antiviral activity against thymidine kinase-deficient Varicella-zoster virus 07-1 infected in human HEL cells assessed as reduction in the virus plaque formation	2011	Bioorganic & medicinal chemistry, Jul-15, Volume: 19, Issue:14	Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
AID383522	Cytotoxicity against african green monkey Vero cells	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID161455	Antiviral activity against KOS strain of herpes simplex virus-1 in primary rabbit kidney cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID63768	The minimum inhibitory concentration was measured on E6SM cells for morphological alteration	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID66007	50% Minimum inhibitory concentration which is required to reduce cytopathogenicity induced by TK-(B2006) strain of HSV-1 virus on human E6SM cells.	1997	Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4	Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.
AID1113469	Antiviral activity against Human herpesvirus 2 strain G infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID326138	Cytotoxicity against african green monkey Vero cells after 2 days	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID85715	Antiviral activity against Herpes Simplex Virus-1(F)	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis and antitumor and antiviral properties of 5-alkyl-2'-deoxyuridines, 3',5'-cyclic monophosphates, and neutral cyclic triesters.
AID81200	Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus VV was measured	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID326132	Activity of Herpes B virus recombinant thymidine kinase at 1 mM	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID275072	Antiviral activity against RSV in HeLa cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID217504	Minimal cytotoxic concentration, the concentration required to cause a microscopically visible alteration of normal cell morphology.	2000	Journal of medicinal chemistry, Dec-28, Volume: 43, Issue:26	Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain.
AID257897	Antiviral activity against Coxsackie virus B4 in vero cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID1382173	Antiviral activity against Human simplex virus 2 G infected in HEL cells assessed as reduction in viral cytopathic effect	2018	European journal of medicinal chemistry, Feb-25, Volume: 146	Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.
AID258992	Antiviral activity against human cytomegalovirus AD169 strain	2006	Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1	Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivatives.
AID1427826	Antiviral activity against thymidine kinase deficient Varicella-Zoster virus 07-1 infected in HEL cells assessed as reduction in virus plaque formation
AID66788	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 100 ug/mL of Urd	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID84418	Compound was tested for antiviral activity against herpes simplex virus( HSV-1-KOS) strain in primary rabbit kidney cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID65712	Antiviral activity against vesicular simplex virus-1 in E6SM cell cultures	2001	Journal of medicinal chemistry, Aug-02, Volume: 44, Issue:16	Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
AID66786	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 10 ug/mL of dUrd and 50 ug/mL of 6-aminothymine	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID1854966	Antiviral activity against Varicella zoster-virus OKA strain harboring thymidine kinase infected in HEL cells assessed as reduction in plaque formation by microscopic analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Synthesis and antiviral properties of biomimetic iminosugar-based nucleosides.
AID634759	Antiviral activity against Punta Toro virus infected in african green monkey Vero cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID569232	Antiviral activity against thymidine kinase deficient acyclovir-resistant HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2011	European journal of medicinal chemistry, Feb, Volume: 46, Issue:2	Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation.
AID167889	Evaluated for the minimum cytotoxic concentration (MCC) upon preincubation of rabbit kidney cells in medium containing 10% fetal calf serum at 37 degree Celsius for 24 hr	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID309813	Antiviral activity against HCMV Davis in HEL cells assessed as reduction of virus plaque formation after 5 days	2007	Bioorganic & medicinal chemistry, Nov-15, Volume: 15, Issue:22	Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV).
AID1402829	Cytotoxicity against HEL cells assessed as reduction in cell viability after 3 days by coulter counting method	2018	European journal of medicinal chemistry, Jan-20, Volume: 144	Emimycin and its nucleoside derivatives: Synthesis and antiviral activity.
AID217663	Compound was evaluated for the antiviral activity against Varicella-Zoster virus (VZV) Oka strain by using plaque reduction assay.	1999	Bioorganic & medicinal chemistry letters, Mar-22, Volume: 9, Issue:6	Synthesis of novel 4'-C-methyl-pyrimidine nucleosides and their biological activities.
AID1361088	Cytostatic activity against human HEL cells after 3 days by coulter counter method	2018	European journal of medicinal chemistry, Jul-15, Volume: 155	Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation.
AID553342	Antiviral activity against VZV OKA expressing thymidine kinase infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 5 days	2011	Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1	Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.
AID218227	Cytotoxicity concentration required to microscopically detectable alteration of cell morphology in Vero	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID1402826	Antiviral activity against HSV1 KOS infected in HEL cells assessed as reduction in virus-induced cytopathic effect after 2 to 3 days	2018	European journal of medicinal chemistry, Jan-20, Volume: 144	Emimycin and its nucleoside derivatives: Synthesis and antiviral activity.
AID103155	The compound was tested for its antiviral activity against HSV-1 (KOS) virus in M-21 (GM137) cell line,	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID275070	Antiviral activity against vesicular somatitis virus in HEL cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID1382171	Antiviral activity against Human simplex virus 1 KOS infected in HEL cells assessed as reduction in viral cytopathic effect	2018	European journal of medicinal chemistry, Feb-25, Volume: 146	Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.
AID52056	Minimum inhibitory concentration required to reduce virus-induced cell growth by 50%	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID209373	Evaluated for the minimum inhibitory concentration (MIC) in primary rabbit kidney (PRK) by 50% against TK- herpes simplex virus type 1 (TK- HSV-1) with strain B2006	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID1394850	Cytostatic activity against HEL cells after 3 days by Coulter counting method	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates.
AID1361087	Antiviral activity against thymidine kinase deficient Varicella-Zoster virus 07-1 infected in human HEL cells assessed as reduction in plaque formation after 5 days	2018	European journal of medicinal chemistry, Jul-15, Volume: 155	Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation.
AID1572732	Cytotoxicity against HEL cells assessed as effect on cell morphology at 0.32 to 200 uM by microscopic analysis	2019	Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6	Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID1782698	Antiviral activity against Varicella zoster virus assessed as inhibition of viral replication	2021	European journal of medicinal chemistry, Aug-05, Volume: 220	Phenoxazine nucleoside derivatives with a multiple activity against RNA and DNA viruses.
AID1498115	Antiviral activity against acyclovir-resistant thymidine kinase deficient Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathicity	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.
AID83524	Anti-VZV activity against OKA strain TK+ in HEL cells	1998	Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25	Synthesis of imidazo[1,2-a]pyridines as antiviral agents.
AID65516	The compound was tested for its antiviral activity against HSV-1 (KOS) virus in E1SM cell line	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID84417	Compound was tested for antiviral activity against herpes simplex virus( HSV-1-F) strain in primary rabbit kidney cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID87159	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against respiratory syncytial virus in HeLa cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID569233	Antiviral activity against HSV2 G infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2011	European journal of medicinal chemistry, Feb, Volume: 46, Issue:2	Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation.
AID1727352	Antiviral activity against thymidine kinase positive Varicella zoster virus OKA infected in human HEL cells assessed as reduction in virus-induced cytopathogenic effect measured after 3 days coulter counter method	2021	European journal of medicinal chemistry, Jan-01, Volume: 209	Extension of furopyrimidine nucleosides with 5-alkynyl substituent: Synthesis, high fluorescence, and antiviral effect in the absence of free ribose hydroxyl groups.
AID63947	Tested for cytotoxic activity in human embryonic skin muscle fibroblast (E6SM)	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID291033	Antiviral activity against parainfluenza 3 virus in Vero cells assessed as reduction of virus plaque formation after 7 days	2007	Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13	Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
AID246450	Concentration required to inhibit human cytomegalovirus strain AD169 induced cytopathogenicity in HEL cells by 50%	2005	Journal of medicinal chemistry, Jul-14, Volume: 48, Issue:14	Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.
AID84953	Compound was evaluated for antiviral activity against HSV-2(strain G)	1984	Journal of medicinal chemistry, Mar, Volume: 27, Issue:3	Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.
AID217648	Minimum inhibitory concentration was determined against VZV (OKA) in HEL cells	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID634761	Antiviral activity against Coxsackievirus B4 infected in human HeLa cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID1854965	Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as reduction in virus-induced cytopathic effect by microscopic analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Synthesis and antiviral properties of biomimetic iminosugar-based nucleosides.
AID658619	Antiviral activity against Vaccinia virus infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID217807	Minimum inhibitory concentration required to reduce vaccinia virus-induced cytopathogenicity in primary rabbit kidney cell cultures	1981	Journal of medicinal chemistry, Jun, Volume: 24, Issue:6	Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID85422	Minimal inhibitory concentration to reduce virus-induced cytopathicity against G strain of human Herpes Simplex Virus-2	2001	Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24	Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study.
AID634832	Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID87160	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against vesicular stomatitis virus in HeLa cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID309811	Antiviral activity against TK- VZV 07/1 in HEL cells assessed as reduction of virus plaque formation	2007	Bioorganic & medicinal chemistry, Nov-15, Volume: 15, Issue:22	Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV).
AID634747	Antiviral activity against Herpes simplex virus 2 G infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID65844	Cytotoxic concentration required to cause microscopically detectable alteration of normal cell morphology of E6SM cells	1996	Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14	Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.
AID45931	Inhibitory concentration against CMV strain AD169 in human embryonic lung (HEL) cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID297320	Antiviral activity against Coxsackie virus B4 in Vero cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID83522	Anti-VZV activity against 07/1 TK- in HEL cells	1998	Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25	Synthesis of imidazo[1,2-a]pyridines as antiviral agents.
AID718738	Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities.
AID90761	50% effective concentration required to reduce cytomegalovirus (CMV Davis strain)-induced cytopathicity	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID216473	Antiviral activity was tested against TK+ Varicella-Zoster virus OKA which reduces virus plaque formation by 50%	2002	Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19	Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles.
AID1410510	Cytotoxicity against HEL cells assessed as morphological changes after 3 days by microscopic analysis	2018	ACS medicinal chemistry letters, Apr-12, Volume: 9, Issue:4	Amidate Prodrugs of Cyclic 9-(
AID84239	50% effective concentration required to reduce herpes simplex virus-1 (HSV- (TK-) VMW 1837 strain)-induced cytopathicity	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID83146	Antiviral activity against VZV (Ellen) in human lung fibroblast (HLF-1) cells	1987	Journal of medicinal chemistry, Jul, Volume: 30, Issue:7	2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID216301	Compound was evaluated for the inhibition of VZV (TK-) thymidine kinases Strain YS-R	1999	Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22	Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base.
AID134099	Topical treatment of intracutaneous TK- herpes simplex virus type 1 of strain VMW 1837 infection of Nu/nu mice for mean day of appearance of skin lesions and/or paralysis of the hind legs at 0.3% concentration (v/v in DMSO)	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID303238	Cytotoxicity against Vero cells assessed as alteration in morphology after 3 days	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID84223	Effective concentration to show 50% of activity was measured on herpes simplex virus-1 KOS strain cell culture.	2000	Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13	Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses.
AID71873	Inhibitory activity against FM3A TK- cell line	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID84590	Minimal inhibitory concentration to reduce virus-induced cytopathicity against KOS strain of human Herpes Simplex Virus -1	2001	Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24	Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study.
AID1382167	Cytotoxicity against HEL cells assessed as alteration of cell morphology by microscopic method	2018	European journal of medicinal chemistry, Feb-25, Volume: 146	Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.
AID284527	Antiviral activity against HSV2 G-induced cytopathogenicity in E6SM cells	2007	Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2	The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
AID156542	The compound was tested for its antiviral activity against HSV-1 (KOS) virus in PRK cell line	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID634749	Antiviral activity against Vaccinia virus infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID84963	Minimum inhibitory concentration required to reduce herpes simplex virus-2 (HSV-2 (196)) virus-induced cytopathicity by 50%	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID304885	Antiviral activity against TK- VZV YS in HEL cells after 5 days	2007	Journal of medicinal chemistry, Dec-27, Volume: 50, Issue:26	Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines.
AID83035	Minimum cytotoxic concentration to reduce the HEL cell proliferation by 50%	1996	Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14	Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.
AID1113467	Antiviral activity against Vesicular stomatitis virus infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID64085	Concentration required to inhibit HSV-1 (McIntyre) induced cytopathogenicity in E6SM cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID257886	Antiviral activity against HEL cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID1457765	Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2017	Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14	Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
AID1410505	Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as inhibition of virus-induced cytopathic effect measured after 2 to 3 days post-infection	2018	ACS medicinal chemistry letters, Apr-12, Volume: 9, Issue:4	Amidate Prodrugs of Cyclic 9-(
AID161458	Antiviral activity against VMW 1837 strain of thymidine kinase deficient (TK-) herpes simplex virus-1 in primary rabbit kidney cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID83716	Ability to reduce plaque formation of herpes simplex virus type 1 (HSV-1) by 50% in human embryonic lung fibroblast (HELF) cell cultures	1988	Journal of medicinal chemistry, Feb, Volume: 31, Issue:2	Synthesis and biological activities of 4-O-(difluoromethyl)-5-substituted-uracil nucleoside analogues.
AID63945	Inhibition of virus-induced cytopathicity in E6SM cell cultures of human embryonic skin-muscle	2002	Journal of medicinal chemistry, Dec-05, Volume: 45, Issue:25	A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.
AID1684816	Antiviral activity against thymidine kinase deficient Varicella zoster virus 07-1 infected in human HEL cells assessed as reduction in virus plaque formation measured on day 5 post-viral infection	2021	ACS medicinal chemistry letters, Jan-14, Volume: 12, Issue:1	Influence of 4'-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2.
AID257898	Antiviral activity against Punta Toro virus in vero cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID280198	Antiviral activity against reovirus1 in Vero cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID72158	Inhibitory activity against FMBA TK-/HSV-2 TK+ cell line	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID161454	Antiviral activity against G strain of herpes simplex virus-2 in primary rabbit kidney cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID165542	Inhibitory activity against incorporation of deoxy-[1',2'-3H]uridine (dUrd) into the DNA of uninfected primary rabbit kidney (PRK) cell cultures	1983	Journal of medicinal chemistry, May, Volume: 26, Issue:5	Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.
AID434311	Antiviral activity against acyclovir-resistant thymidine kinase-deficient HSV1 KOS infected in human HEL cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID326134	Antiviral activity against Herpes B virus 24105 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID482708	Antiviral activity against RSV infected in human HeLa cell assessed as inhibition of virus-induced cytopathicity	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	"Viologen" dendrimers as antiviral agents: the effect of charge number and distance.
AID766697	Antiviral activity against Vesicular stomatitis virus infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID1402827	Antiviral activity against acyclovir-resistant HSV1 KOS harboring TK- mutant infected in HEL cells assessed as reduction in virus-induced cytopathic effect after 2 to 3 days	2018	European journal of medicinal chemistry, Jan-20, Volume: 144	Emimycin and its nucleoside derivatives: Synthesis and antiviral activity.
AID86500	The compound was tested for antiviral activity against VSV-virus in human epithelial cells	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID84961	Minimum inhibitory concentration against HSV-2.	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID1230103	Antiviral activity against thymidine kinase-deficient acyclovir-resistant Herpes simplex virus 1 KOS infected in HEL cells assessed as reduction of virus-induced cytopathogenicity	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues.
AID63755	Tested for the minimum inhibitory concentration required to reduce vesicular stomatitis virus(VSV) induced cytopathogenicity by 50%	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID88278	Evaluated for minimum inhibitory concentration against TK-B2006 strain of Herpes simplex virus (HSV-1) in primary rabbit kidney cells	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one.
AID1294506	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by MTS assay	2016	Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9	L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation.
AID611624	Cytotoxicity against human HEL cells assessed as alteration of cell morphology after 3 days by microscopy	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	New prodrugs of Adefovir and Cidofovir.
AID81196	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against TK- VZV virus in HEL cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID217480	Minimum inhibitory concentration required to reduce VSV virus-induced cytopathicity by 50%	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID217654	Minimum inhibitory concentration was determined against VZV (TK-YS/R) in HEL cells	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID63764	The minimum inhibitory concentration was measured on E6SM cells against TK+/TK-Herpes simplex virus type 1 (VMW1837 strain)	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID216540	Antiviral activity against vesicular stomatitis virus	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis and antitumor and antiviral properties of 5-alkyl-2'-deoxyuridines, 3',5'-cyclic monophosphates, and neutral cyclic triesters.
AID83325	The minimum inhibitory concentration was measured on HEL cells against Cytomegalovirus virus (Davis strain)	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID81757	Minimum toxic effect against HEp-2 cells.	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID156705	Evaluation for antiviral activity against herpes simplex virus-1(TK-) (B2006) in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID217488	Inhibitory concentration against VV in human embryonic skin muscle (ESM) fibroblast cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID216348	Tested for antiviral activity against Sindbis virus in African green monkey kidney cell (Vero)	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID303235	Antiviral activity against Sindbis virus in Vero cells reduction of virus-induced cytopathogenicity after 4 days	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID1294503	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTS assay	2016	Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9	L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation.
AID766698	Antiviral activity against Vaccinia virus Lederle infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID85432	Inhibition constant against HSV-1 TK	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID766704	Antiviral activity against thymidine kinase positive Varicella-zoster virus OKA infected in human HEL cells assessed as reduction in virus plaque formation	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID1337439	Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus plaque formation	2016	European journal of medicinal chemistry, Nov-29, Volume: 124	Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor.
AID84965	Minimum inhibitory concentration required to reduce herpes simplex virus-2 (HSV-2 (Lyons)) virus-induced cytopathicity by 50%	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID66001	50% Minimum inhibitory concentration which is required to reduce cytopathogenicity induced by (196) strain of HSV-2 virus on human E6SM cells.	1997	Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4	Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.
AID326127	Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylation	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID326128	Inhibition of Herpes simplex virus 1 recombinant thymidine kinase	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID634834	Antiviral activity against Influenza B virus infected in MDCK cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID1337441	Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as inhibition of virus plaque formation	2016	European journal of medicinal chemistry, Nov-29, Volume: 124	Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor.
AID1382174	Antiviral activity against Vaccinia virus infected in HEL cells assessed as reduction in viral cytopathic effect	2018	European journal of medicinal chemistry, Feb-25, Volume: 146	Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.
AID548428	Antiviral activity against thymidine kinase deficient acyclovir-resistant Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID64117	Tested for minimum inhibitor concentration against vesicular stomatitis virus (VSV) in E6SM cells.	1993	Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20	Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents.
AID85246	The compound was tested for its antiviral activity against HSV-1 (KOS) virus in HSF (VGS) cell line	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID86216	Antiviral activity against HSV-2 (K979) in human epithelial (Hep-2) cells	1987	Journal of medicinal chemistry, Jul, Volume: 30, Issue:7	2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID83191	Minimum inhibitory conc. for 50% inhibition of TK VZV (07/1) virus plaque formation in HEL cells	1997	Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9	Carbocyclic oxetanocins lacking the C-3' methylene.
AID87824	Minimum inhibitory concentration required to reduce HSV-2 (G) strain-induced cytopathogenicity in primary rabbit kidney cell cultures	1981	Journal of medicinal chemistry, Jun, Volume: 24, Issue:6	Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID634757	Antiviral activity against Sindbis virus infected in african green monkey Vero cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID156701	Antiviral activity against HSV-2 (G) in Primary Rabbit Kidney (PRK) cells	1987	Journal of medicinal chemistry, Jul, Volume: 30, Issue:7	2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID86022	Inhibition of plaque formation in monolayers of HSV-1 KOS Vero cells by 50%	2001	Journal of medicinal chemistry, Oct-11, Volume: 44, Issue:21	Synthesis and antiviral activity of novel 5-(1-cyanamido-2-haloethyl) and 5-(1-hydroxy(or methoxy)-2-azidoethyl) analogues of uracil nucleosides.
AID81202	Minimum inhibitory concentration required to reduce virus induced plaque formation in HEL cell culture of virus CMV (Davis) was measured	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID165526	Concentration required to reduce Herpes simplex virus type 1 induced cytopathogenicity in primary rabbit kidney (PRK) cell cultures	1983	Journal of medicinal chemistry, May, Volume: 26, Issue:5	Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.
AID388921	Antiviral activity against human cytomegalovirus Davis in HEL cells assessed as inhibition of viral cytopathicity	2008	Bioorganic & medicinal chemistry, Nov-01, Volume: 16, Issue:21	Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): part II.
AID275076	Antiviral activity against Punta Toro virus in Vero cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID85893	Inhibition of plaque formation in monolayers of HSV-1 E-377 Vero cells by 50%	2001	Journal of medicinal chemistry, Oct-11, Volume: 44, Issue:21	Synthesis and antiviral activity of novel 5-(1-cyanamido-2-haloethyl) and 5-(1-hydroxy(or methoxy)-2-azidoethyl) analogues of uracil nucleosides.
AID1869614	Cytotoxicity against human HEL cells assessed as change in cell morphology measured after 3 days by coulter counting method	2022	Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13	Reshaping an Acyclic Nucleoside Phosphonate into a Selective Anti-hepatitis B Virus Compound.
AID68118	Concentration required to cause a microscopically detectable alteration of normal ESM cell morphology.	1992	Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12	(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties.
AID434314	Antiviral activity against RSV infected in human HeLa cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID156700	Antiviral activity against HSV-1 (KOS) in Primary Rabbit Kidney (PRK) cells	1987	Journal of medicinal chemistry, Jul, Volume: 30, Issue:7	2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID257888	Antiviral activity against HeLa cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID303211	Antiviral activity against HSV2 Lyons in HEL cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID1422438	Antiviral activity against Herpes simplex virus 1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by microscopic method	2018	Bioorganic & medicinal chemistry letters, 11-15, Volume: 28, Issue:21	Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents.
AID217593	In vitro antiviral activity was determined by plaque-reduction assay in HSV-1(strain 2931) infected Vero cell monolayers	1984	Journal of medicinal chemistry, Jan, Volume: 27, Issue:1	Nucleosides. 129. Synthesis of antiviral nucleosides: 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracils.
AID87995	Antiviral activity against herpes simplex type-2 expressed as ED90	1985	Journal of medicinal chemistry, Jun, Volume: 28, Issue:6	Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents.
AID134097	Topical treatment of intracutaneous HSV-1(KOS) herpes simplex virus type 1 infection of Nu/nu mice for mean day of appearance of skin lesions and/or paralysis of the hind legs at 1% concentration (v/v in DMSO)	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID766711	Cytotoxicity against human HEL cells assessed as morphological changes	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID675220	Antiviral activity against Vaccinia virus Lederie infected in HEL cells by viral CPE assay	2012	European journal of medicinal chemistry, Sep, Volume: 55	Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
AID139990	Inhibition constant assumed to reflect the affinity for the transport site in mouse erythrocytes	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID88277	Evaluated for minimum inhibitory concentration against KOS, F, McIntyre strains of Herpes simplex virus (HSV-1) in primary rabbit kidney cells	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one.
AID1394847	Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as inhibition of plaque formation measured after 6 to 7 days post infection	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates.
AID83500	Cytotoxic concentration to reduce HEL cell growth by 50%; ND denotes no data	2002	Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19	Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles.
AID766696	Antiviral activity against thymidine kinase negative acyclovir positive Herpes simplex virus-1 KOS infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID1610164	Antiviral activity against Herpes simplex virus 2 G infected in human HELF cells assessed as reduction in virus-induced cytopathogenicity incubated for 7 days by microscopic analysis	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID1230102	Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as reduction of virus-induced cytopathogenicity	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues.
AID83895	Minimum inhibitory concentration required to reduce herpes simplex virus-1 (HSV-1 (F)) virus-induced cytopathicity by 50%	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID81030	The compound was tested for antiviral activity by measuring the concentration required to reduce plaque formation against Varicella zoster TK-(deficient) 07/1 strain	1999	Journal of medicinal chemistry, Jul-15, Volume: 42, Issue:14	Novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis and biological evaluation.
AID84761	Antiviral activity against Herpes Simplex Virus-2(G)	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID288919	Antiviral activity against thymidine kinase-deficient HSV1 B2006 in E6SM cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Jun-14, Volume: 50, Issue:12	5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
AID156686	Inhibitory concentration required to reduce incorporation of 2-deoxyuridine (dUrd) into DNA of Primary Rabbit kidney (PRK) cell cultures	1984	Journal of medicinal chemistry, Nov, Volume: 27, Issue:11	Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID464179	Cytotoxicity against Herpes simplex virus 2 G infected HEL cells by trypan blue exclusion method	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID87994	Antiviral activity against herpes simplex type-2 expressed as ED50	1985	Journal of medicinal chemistry, Jun, Volume: 28, Issue:6	Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents.
AID569235	Antiviral activity against VZV 07-1 infected in HEL cells assessed as inhibition of plaque formation	2011	European journal of medicinal chemistry, Feb, Volume: 46, Issue:2	Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation.
AID221318	Evaluated for the minimum inhibitory concentration (MIC) in primary rabbit kidney (PRK) by 50% against herpes simplex virus type-1 (HSV-1) with strains F	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID82895	Tested for the inhibitory concentration required to reduce TK+ Varicella-Zoster virus (TK+ VZV) strain OKA plaque formation by 50%.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID1661190	Antiviral activity against thymidine kinase deficient Varicella zoster virus 07-1 infected in human HEL cells assessed as reduction in plaque formation measured after 5 days	2020	ACS medicinal chemistry letters, Jul-09, Volume: 11, Issue:7	Amidate Prodrugs of
AID611622	Antiviral activity against Feline herpesvirus infected in CRFK cells assessed as protection against virus-induced cytopathicity	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	New prodrugs of Adefovir and Cidofovir.
AID68122	Concentration required to reduce HSV-2(G) induced cytopathogenicity by 50% in ESM(embryonic skin muscle) cell cultures.	1992	Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12	(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties.
AID83528	Anti-VZV activity against YS/R TK- in HEL cells	1998	Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25	Synthesis of imidazo[1,2-a]pyridines as antiviral agents.
AID84765	Antiviral activity against Herpes Simplex Virus-2(G)	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis and antitumor and antiviral properties of 5-alkyl-2'-deoxyuridines, 3',5'-cyclic monophosphates, and neutral cyclic triesters.
AID1328754	Cytostatic activity against mouse L1210 cells after 2 days by cell counting method	2016	Bioorganic & medicinal chemistry letters, 12-01, Volume: 26, Issue:23	ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites.
AID548424	Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID84767	Concentration required to reduce HSV-2 virus induced cytopathogenicity in rabbit cell kidney culture (196 cells)	1988	Journal of medicinal chemistry, Jan, Volume: 31, Issue:1	Synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2'-deoxycytidine-related compounds.
AID64090	Concentration required to inhibit TK-HSV-1 (B2006) induced cytopathogenicity in E6SM cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID434312	Antiviral activity against Vesicular stomatitis virus infected in human HeLa cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID81206	Minimum inhibitory concentration required to reduce virus induced plaque formation in HEL cell culture of virus VZS (YS) was measured	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID85712	Antiviral activity against Herpes Simplex Virus-1 (F)	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID1427833	Antiviral activity against thymidine kinase-deficient acyclovir-resistant Herpes simplex virus 1 KOS infected in HEL cells assessed as reduction in virus-induced cytopathogenicity
AID246487	Effective concentration required to reduce Varicella-Zoster virus 07/1(TK-) plaque formation after 5 days in HEL fibroblast cell line	2005	Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7	From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors.
AID383518	Antiviral activity against in Vesicular stomatitis virus in human E6SM cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID83020	Tested for the inhibitory concentration required to reduce cytomegalovirus (CMV) strain AD-169 plaque formation by 50%.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID1661188	Antiviral activity against Cytomegalovirus Davis infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity measured after 6 to 7 days	2020	ACS medicinal chemistry letters, Jul-09, Volume: 11, Issue:7	Amidate Prodrugs of
AID675213	Antiviral activity against thymidine kinase negative VZV YS/R infected in HEL cells by plaque formation assay	2012	European journal of medicinal chemistry, Sep, Volume: 55	Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
AID611626	Cytotoxicity against cat CRFK cells assessed as growth inhibition after 3 days by coulter counter	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	New prodrugs of Adefovir and Cidofovir.
AID383530	Antiviral activity against Parainfluenza 3 virus in african green monkey Vero cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID611625	Cytotoxicity against human HEL cells assessed as growth inhibition after 3 days by coulter counter	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	New prodrugs of Adefovir and Cidofovir.
AID81218	Cytotoxicity concentration required to microscopically detectable alteration of cell morphology HEL	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID218509	Effective concentration required to reduce coxsackie virus B4-induced cytopathicity in vero cells	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID66772	The compound was tested for its antiviral activity against vesicular stomatitis virus in E6SM cell culture	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID83048	50% Minimum inhibitory concentration which is required to reduce cytopathogenicity induced by (Lyons) strain of HSV-2 virus on human embryonic HEL cells.	1997	Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4	Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.
AID516967	Antiviral activity against acyclovir-resistant HSV2 strain G infected in HEL assessed as reduction in virus-induce cytopathicity	2010	Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19	Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents.
AID66943	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against vesicular stomatitis virus in E6SM cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID83893	Minimum inhibitory concentration against HSV-1.	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID66766	The compound was tested for its antiviral activity against HSV-1 (McIntyre) virus in E6SM cell culture	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID84228	Inhibitory activity against HSV-1 (McIntyre) replication in E6SM cell cultures of human embryonic skin-muscle	2002	Journal of medicinal chemistry, Dec-05, Volume: 45, Issue:25	A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.
AID216155	Effective concentration against TK- Varicella-Zoster Virus (VZV) 07/1 strain	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID419592	Antiviral activity against HSV1 KOS infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity after 3 days	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID288938	Inhibition of proliferation of thymidine kinase deficient OST cells	2007	Journal of medicinal chemistry, Jun-14, Volume: 50, Issue:12	5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
AID297321	Antiviral activity against Punta Toro virus in Vero cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID516969	Antiviral activity against acyclovir-resistant VZV 07/1 infected in HEL assessed as reduction in virus-induce cytopathicity	2010	Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19	Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents.
AID224697	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 25 mg/kg at day 0	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID84415	Compound was tested for antiviral activity against herpes simplex virus (thymidine kinase deficient herpes simplex virus ( HSV-1 (B2006) in primary rabbit kidney cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID64111	Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus TK- HSV-1 (VMW1837) was measured	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID675217	Antiviral activity against HCMV AD169 infected in HEL cells by viral CPE assay	2012	European journal of medicinal chemistry, Sep, Volume: 55	Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
AID1661192	Cytotoxicity against human HEL cells assessed as reduction in cell proliferation incubated for 3 days by Coulter counter method	2020	ACS medicinal chemistry letters, Jul-09, Volume: 11, Issue:7	Amidate Prodrugs of
AID1251998	Cytotoxicity against Varicella zoster virus infected HEL cells assessed as cell growth inhibition incubated for 3 days by coulter counter method	2015	Bioorganic & medicinal chemistry, Nov-01, Volume: 23, Issue:21	Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides.
AID1422440	Antiviral activity against acyclovir-resistant TK-defecient Herpes simplex virus 1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by microscopic method	2018	Bioorganic & medicinal chemistry letters, 11-15, Volume: 28, Issue:21	Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents.
AID217819	Concentration required to reduce vaccinia virus induced cytopathogenicity in rabbit cell kidney culture	1988	Journal of medicinal chemistry, Jan, Volume: 31, Issue:1	Synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2'-deoxycytidine-related compounds.
AID161452	Antiviral activity against B2006 strain of thymidine kinase deficient (TK-) herpes simplex virus-1 in primary rabbit kidney cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID68119	Concentration required to reduce HSV-1 thymidine kinase deficient (TK-)(B2006) induced cytopathogenicity by 50% in ESM(embryonic skin muscle) cell cultures.	1992	Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12	(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties.
AID224693	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 100 mg/kg at day 20	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID516965	Antiviral activity against HSV1 KOS infected in HEL assessed as reduction in virus-induce cytopathicity	2010	Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19	Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents.
AID83499	Cytotoxic concentration reducing HEL cell growth by 50%.	2002	Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19	Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles.
AID280178	Antiviral activity against HSV2 G in HEL cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID280206	Cytotoxicity against C3H cells assessed as alteration in cell morphology	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID209538	Inhibitory concentration against TK-VZV strain 07-1 in human embryonic lung (HEL) cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID1710791	Antiviral activity against Herpes simplex virus 2 infected in human HEL cells assessed as reduction in virus-induced cytopathic effect incubated for 3 to 6 days by light microscopic analysis	2016	Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2	Synthesis and antiviral properties of novel indole-based thiosemicarbazides and 4-thiazolidinones.
AID83205	Tested for antiviral activity against thymidine kinase wild type Varicella zoster virus in human embryonic lung fibroblast	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID288917	Antiviral activity against HSV2 G in E6SM cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Jun-14, Volume: 50, Issue:12	5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
AID120304	In vivo evaluation for the percent survivors in systemic HSV-1 infection of Mice administered through oral route at a dose 50 mg/kg per day	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID84768	Concentration required to reduce HSV-2 virus induced cytopathogenicity in rabbit cell kidney culture (G cells)	1988	Journal of medicinal chemistry, Jan, Volume: 31, Issue:1	Synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2'-deoxycytidine-related compounds.
AID218512	Effective concentration required to reduce sindbis virus-induced cytopathicity in vero cells	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID326131	Activity of Herpes B virus recombinant thymidine kinase at 100 uM	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID224692	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 100 mg/kg at day 12	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID66795	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 3 ug/mL dThd	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID1869611	Antiviral activity against HCMV Davis infected in HEL cells assessed as reduction in virus plaque formation	2022	Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13	Reshaping an Acyclic Nucleoside Phosphonate into a Selective Anti-hepatitis B Virus Compound.
AID416773	Antiviral activity against HSV1 KOS in human HEL cells assessed as protection against virus-induced cytopathicity	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID84964	Minimum inhibitory concentration required to reduce herpes simplex virus-2 (HSV-2 (G)) virus-induced cytopathicity by 50%	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID304884	Antiviral activity against TK- VZV 07 in HEL cells after 5 days	2007	Journal of medicinal chemistry, Dec-27, Volume: 50, Issue:26	Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines.
AID383514	Antiviral activity against HSV2 G in human E6SM cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID1854960	Cytotoxicity against HEL cells assessed as alteration of cell morphology by microscopic analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Synthesis and antiviral properties of biomimetic iminosugar-based nucleosides.
AID221302	Compound was tested for antiviral activity against herpes simplex Vassicular stomatitis in primary rabbit kidney cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID665383	Antiviral activity against thymidine kinase-positive Varicella-zoster virus YS infected in HEL cells assessed as reduction in virus-induced cytopathicity	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and antiviral evaluation of C5-substituted-(1,3-diyne)-2'-deoxyuridines.
AID66765	The compound was tested for its antiviral activity against HSV-1 (KOS) virus in E6SM cell culture	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID151170	Cytotoxic concentration that causes growth inhibition of VZV infected Osteosarcoma cells	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID257899	Antiviral activity against Respiratory syncytial virus in HeLa cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID216410	Evaluated for minimum inhibitory concentration against Vesicular stomatitis virus (VSV) in primary rabbit kidney cells	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one.
AID288939	Inhibition of proliferation of VZV thymidine kinase expressing OSTtk-/VZVtk+ -a cells	2007	Journal of medicinal chemistry, Jun-14, Volume: 50, Issue:12	5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
AID1410508	Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as inhibition of virus-induced cytopathic effect measured after 6 to 7 days post-infection	2018	ACS medicinal chemistry letters, Apr-12, Volume: 9, Issue:4	Amidate Prodrugs of Cyclic 9-(
AID304883	Antiviral activity against TK+ VZV YS in HEL cells after 5 days	2007	Journal of medicinal chemistry, Dec-27, Volume: 50, Issue:26	Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines.
AID84085	Minimum inhibitory concentration was determined against HSV-1 (F) in E6SM cell culture	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID118655	Compound was evaluated in nu/nu mice infected with TK- HSV-1 (VMW-1837) to increase the mean survival time when applied topically at 10% after 52 days	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID84409	Minimal inhibitory concentration to reduce virus-induced cytopathicity against TK-/TK+ HSV-1 of VMW 837	2001	Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24	Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study.
AID246562	Effective concentration required to reduce TK+ (thymidine kinase deficient) VZV strain YS/R virus plaque formation by 50% in HEL cell culture	2004	Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22	6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains.
AID607911	Cytotoxicity against human HEL cells assessed as alteration of normal cell morphology by microscopic analysis	2011	Bioorganic & medicinal chemistry, Jul-15, Volume: 19, Issue:14	Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
AID87149	Evaluation for antiviral activity against vesicular stomatitis virus in HeLa cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID156860	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in PRK cell culture by 50% in presence of specified concentrations of 6-aminothymine	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID297313	Antiviral activity against Parainfluenza 3 virus in Vero cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID434317	Antiviral activity against Sindbis virus infected in african green monkey Vero cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID284538	Antiviral activity against Coxsackie virus B4-induced cytopathogenicity in Vero cells	2007	Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2	The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
AID85419	Compound was tested for antiviral activity against herpes simplex virus( HSV-2-G) strain in primary rabbit kidney cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID68255	Minimum inhibitory concentration required for antiviral activity to reduce Vaccinia virus (VV) induced cytopathicity in human embryonic skin-muscle cells (ESM)	1994	Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9	Synthesis and antiviral activities of 8-alkynyl-, 8-alkenyl-, and 8-alkyl-2'-deoxyadenosine analogues.
AID167134	Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against HSV-1 (F)	1983	Journal of medicinal chemistry, Apr, Volume: 26, Issue:4	Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID81049	Concentration required to cause 50% reduction in HEL cell growth.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID516968	Antiviral activity against acyclovir-resistant VZV OKA infected in HEL assessed as reduction in virus-induce cytopathicity	2010	Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19	Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents.
AID1402822	Antiviral activity against HCMV AD169 infected in HEL cells assessed as reduction in virus-induced cytopathic effect after 6 to 7 days	2018	European journal of medicinal chemistry, Jan-20, Volume: 144	Emimycin and its nucleoside derivatives: Synthesis and antiviral activity.
AID569231	Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2011	European journal of medicinal chemistry, Feb, Volume: 46, Issue:2	Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation.
AID165524	Concentration of compound required to inhibit [methyl-3H]dThd incorporation into host cell DNA by 50% in primary rabbit kidney cell cultures	1984	Journal of medicinal chemistry, Mar, Volume: 27, Issue:3	Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.
AID83534	Minimum cytotoxic concentration against HEL cell morphology; ND denotes no data	2002	Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19	Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles.
AID216172	Minimum Inhibition Concentration (MIC) for activity against Varicella-Zoster Virus(VZV) using YS/R (TK-) strain.	1996	Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14	Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.
AID83184	Concentration required to reduce varicella zoster virus (VZV)YS-TK-PFU plaque formation by 50% in human embryonic lung (HEL) cell cultures.	1992	Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12	(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties.
AID768206	Antiviral activity against TK-positive Varicella-zoster virus OKA infected in human HEL cells assessed as reduction of plaque formation	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID81219	Cytotoxicity concentration required to reduce cell growth by 50% in HEL	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID284537	Antiviral activity against Sindbis virus-induced cytopathogenicity in Vero cells	2007	Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2	The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
AID66789	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 100 ug/mL of Urd and 50 ug/mL of 6-aminothymine	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID275075	Antiviral activity against Sindbis virus in Vero cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID66778	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 1 ug/mL of Urd	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID81035	The compound was tested for antiviral activity by measuring the concentration required to reduce plaque formation against cytomegalo virus AD-169 strain; Not determined	1999	Journal of medicinal chemistry, Jul-15, Volume: 42, Issue:14	Novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis and biological evaluation.
AID718733	Toxicity in HEL cells assessed as induction of cell morphology changes	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities.
AID156704	Evaluation for antiviral activity against herpes simplex virus-1 (McIntyre) in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID63617	Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-1) strain KOS induced cytopathogenicity by 50%.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID84071	Compound was evaluated for antiviral activity against HSV-1(TK-, strain B2006)	1984	Journal of medicinal chemistry, Mar, Volume: 27, Issue:3	Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.
AID86209	Proliferation of Hep-2 cells by propagation on day 4 by measuring optical density (absorbance) at 330 ug/mL	1987	Journal of medicinal chemistry, Jul, Volume: 30, Issue:7	2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID244774	Minimum cytotoxic concentration that caused a microscopically detectable alteration of cell morphology in E6SM Cell Culture	2004	Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22	6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains.
AID1382166	Antiviral activity against thymidine kinase deficient Varicella zoster virus 07/1 infected in HEL cells assessed as reduction in viral plaque formation	2018	European journal of medicinal chemistry, Feb-25, Volume: 146	Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.
AID1610152	Antiviral activity against thymidine kinase positive Varicella zoster virus infected in human HELF cells assessed as reduction in virus-induced cytopathogenicity incubated for 7 days by Giemsa staining based microscopic analysis	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID87823	Minimum inhibitory concentration required to reduce HSV-2 (196) strain-induced cytopathogenicity in primary rabbit kidney cell cultures	1981	Journal of medicinal chemistry, Jun, Volume: 24, Issue:6	Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID658739	Antiviral activity against Vesicular stomatitis virus infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID388922	Cytotoxicity against HEL cells assessed as morphological alteration after 3 days	2008	Bioorganic & medicinal chemistry, Nov-01, Volume: 16, Issue:21	Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): part II.
AID68253	Minimum inhibitory concentration required for antiviral activity to reduce HSV-2 (G) induced cytopathicity in human embryonic skin-muscle cells (ESM)	1994	Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9	Synthesis and antiviral activities of 8-alkynyl-, 8-alkenyl-, and 8-alkyl-2'-deoxyadenosine analogues.
AID105824	Minimum inhibitory concentration required to reduce cytopathogenicity of Varicella Zoster Virus (VZV) in MRC-5 cells by 50%.	1991	Journal of medicinal chemistry, Sep, Volume: 34, Issue:9	The synthesis and antiviral activity of some 4'-thio-2'-deoxy nucleoside analogues.
AID675215	Antiviral activity against HSV2 G infected in HEL cells by viral CPE assay	2012	European journal of medicinal chemistry, Sep, Volume: 55	Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
AID87157	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against coxsackie B4 virus in HeLa cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID548427	Antiviral activity against Vesicular stomatitis virus infected in HEL cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID286285	Cytotoxicity against Kaposi's sarcoma-associated herpesvirus infected BC3 cells after 120 hrs by MTT assay	2007	Journal of medicinal chemistry, May-03, Volume: 50, Issue:9	9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus.
AID156703	Evaluated for antiviral activity against herpes simplex virus-1(KOS) in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID218375	Cytotoxic dose of compound required to reduce the viability of normal uninfected vero cells by 50%.	1994	Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1	S-glucosylated hydantoins as new antiviral agents.
AID383519	Antiviral activity against in Vesicular stomatitis virus in human HEL cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID66784	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 10 ug/mL of Urd and 50 ug/mL of 6-aminothymine,	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID429196	Antiviral activity against Varicella zoster virus YS infected in human HEL cells assessed as inhibition of virus induced cytopathicity after 5 days	2009	European journal of medicinal chemistry, Aug, Volume: 44, Issue:8	Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl}guanine analogues.
AID43638	Antiherpes activity was tested as percent of control of plaque-formation against BVdUr virus by 30 uM of the compound	1985	Journal of medicinal chemistry, Jul, Volume: 28, Issue:7	Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID87506	Evaluation of antiviral activity against Herpes simplex virus type 1 (HSV-1) strain F	1986	Journal of medicinal chemistry, Jul, Volume: 29, Issue:7	Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID65995	Compound was evaluated for the minimum cytotoxic concentration required to cause a microscopically detectable alteration of normal cell morphology.	1998	Journal of medicinal chemistry, Oct-22, Volume: 41, Issue:22	5-Substituted pyrimidines with a 1,5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase.
AID607910	Antiviral activity against Vaccinia virus infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis	2011	Bioorganic & medicinal chemistry, Jul-15, Volume: 19, Issue:14	Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
AID216349	Tested for antiviral activity against coxsackie B-4 virus in African green monkey kidney cell (Vero)	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID548426	Antiviral activity against Vaccinia virus infected in HEL cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID217900	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against junin virus in Vero cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID63763	The minimum inhibitory concentration was measured on E6SM cells against Herpes simplex virus type 2 (Lyons strain)	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID1382168	Cytostatic activity against HEL cells after 3 days by Coulter counting method	2018	European journal of medicinal chemistry, Feb-25, Volume: 146	Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.
AID275069	Antiviral activity against vaccinia virus in HEL cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID553339	Antiviral activity against acyclovir-resistant thymidine kinase deficient HSV1 KOS infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days	2011	Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1	Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.
AID71878	Concentration required to cause a microscopically detectable alteration of normal cell morphology	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID134100	Topical treatment of intracutaneous TK- herpes simplex virus type 1 of strain VMW 1837 infection of Nu/nu mice for mean day of appearance of skin lesions and/or paralysis of the hind legs at 1% concentration (v/v in DMSO)	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID217420	Proliferation of Vero cells by propagation on day 4 by measuring optical density (absorbance) at 30 ug/mL	1987	Journal of medicinal chemistry, Jul, Volume: 30, Issue:7	2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID63601	Minimum inhibitory conc. for 50% inhibition of vesicular stomatitis virus induced cytopathicity in E6SM cells	1997	Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9	Carbocyclic oxetanocins lacking the C-3' methylene.
AID67101	Effective concentration for the inhibition of Epstein-Barr virus EBV-DNA synthesis in human lymphoblastoid P3HR-1 cells	2002	Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23	CycloSal-BVDUMP pronucleotides: how to convert an antiviral-inactive nucleoside analogue into a bioactive compound against EBV.
AID675218	Antiviral activity against HCMV Davis infected in HEL cells by viral CPE assay	2012	European journal of medicinal chemistry, Sep, Volume: 55	Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
AID1230105	Antiviral activity against Vaccinia virus infected in HEL cells assessed as reduction of virus-induced cytopathogenicity	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues.
AID258989	Antiviral activity against Varicella-Zoster virus YS strain	2006	Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1	Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivatives.
AID134096	Topical treatment of intracutaneous HSV-1(KOS) herpes simplex virus type 1 infection of Nu/nu mice for mean day of appearance of skin lesions and/or paralysis of the hind legs at 0.3% concentration (v/v in DMSO)	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID156708	Evaluation for antiviral activity against herpes simplex virus-2(Lyons) in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID718737	Antiviral activity against HSV2 G infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities.
AID224707	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 250 mg/kg at day 6	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID392537	Antiviral activity against Varicella zoster virus	2009	Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2	Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
AID246523	Effective concentration required to reduce TK+ (thymidine kinase presence) VZV strain YS virus plaque formation by 50% in HEL cell culture	2004	Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22	6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains.
AID64104	Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-1 (Mc Intyre) was measured	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID120300	In vivo evaluation for the percent survivors in systemic HSV-1 infection of Mice administered through oral route at a dose 100 mg/kg per day; NT=Not tested	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID66763	oncentration required to inhibit VV induced cytopathogenicity in E6SM cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID388923	Cytotoxicity against HEL cells assessed as reduction of growth after 3 days	2008	Bioorganic & medicinal chemistry, Nov-01, Volume: 16, Issue:21	Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): part II.
AID66787	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 100 ug/mL dThd	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID611623	Antiviral activity against Vaccinia virus infected in HEL cells assessed as protection against virus-induced cytopathicity	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	New prodrugs of Adefovir and Cidofovir.
AID84084	Inhibitory activity against HSV-1 (F) replication in E6SM cell cultures of human embryonic skin-muscle	2002	Journal of medicinal chemistry, Dec-05, Volume: 45, Issue:25	A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.
AID216038	Inhibitory activity against herpes simplex virus type 1 (HSV-1) strain SC16 in Vero cells.	1996	Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3	Synthesis and anti-herpes virus activity of 2'-deoxy-4'-thiopyrimidine nucleosides.
AID1872793	Antiviral activity against VZV strain Oka bearing wild type thymidine kinase assessed as reduction in virus induced cytopathogenicity	2022	European journal of medicinal chemistry, Apr-15, Volume: 234	Recent applications of vinyl sulfone motif in drug design and discovery.
AID66933	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of specified concentrations of 6-aminothymine	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID87137	Evaluation in HeLa cell cultures for cytotoxicity that is to cause microscopically detectable alteration of normal cell morphology	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID280190	Antiviral activity against HIV2 ROD in human CEM cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID104933	The compound was tested for its antiviral activity against HSV-1 (KOS) virus in MO cell line	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID66019	Compound was evaluated for the minimum inhibition concentration required to reduce virus-induced cytopathogenicity by 50%, determined against HSV-2 virus as means of G, 196, and Lyons strains	1998	Journal of medicinal chemistry, Oct-22, Volume: 41, Issue:22	5-Substituted pyrimidines with a 1,5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase.
AID68257	Minimum inhibitory concentration to reduce cytopathicity by 50% in morphology of human embryonic skin-muscle cells (ESM)	1994	Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9	Synthesis and antiviral activities of 8-alkynyl-, 8-alkenyl-, and 8-alkyl-2'-deoxyadenosine analogues.
AID112423	Concentration required to reduce leukemia L1210 cell growth in mice	1983	Journal of medicinal chemistry, May, Volume: 26, Issue:5	Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.
AID84407	Minimal inhibitory concentration to reduce virus-induced cytopathicity against Thymidine kinase deficient(TK-) HSV-1 of Acyclovir	2001	Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24	Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study.
AID84218	Inhibitory activity against TK-deficient HSV-1 (KOS) replication in E6SM cell cultures of human embryonic skin-muscle	2002	Journal of medicinal chemistry, Dec-05, Volume: 45, Issue:25	A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.
AID607909	Antiviral activity against Herpes simplex virus-2 G infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis	2011	Bioorganic & medicinal chemistry, Jul-15, Volume: 19, Issue:14	Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
AID383517	Antiviral activity against Vaccinia virus in human HEL cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID275068	Antiviral activity against HSV2 in HEL cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID280199	Antiviral activity against sindbis virus in Vero cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID134098	Topical treatment of intracutaneous HSV-1(KOS) herpes simplex virus type 1 infection of Nu/nu mice for mean day of appearance of skin lesions and/or paralysis of the hind legs at 3% concentration (v/v in DMSO)	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
AID81199	Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus VSV was measured	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID224694	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 100 mg/kg at day 3	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID63761	The minimum inhibitory concentration was measured on E6SM cells against Herpes simplex virus type 2 (196 strain)	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID81204	Minimum inhibitory concentration required to reduce virus induced plaque formation in HEL cell culture of virus TK- VZV (YS-R) was measured	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID634746	Antiviral activity against Herpes simplex virus 1 KOS infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID257887	Antiviral activity against vero cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID83034	Compound was evaluated for the cytotoxicity against HEL cells	1999	Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22	Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base.
AID217903	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against reo type 1 virus in Vero cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID81197	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against VZV virus in HEL cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID63605	Tested for antiviral activity against herpes simplex virus type 1(KOS) in E6SM cell line(human embryonic skin-muscle fibroblasts)	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID634750	Antiviral activity against Vesicular stomatitis virus infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID1422437	Cytotoxicity against HEL cells assessed as alteration in cell morphology after 3 days by microscopic method	2018	Bioorganic & medicinal chemistry letters, 11-15, Volume: 28, Issue:21	Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents.
AID1325059	Antiviral activity against Vaccinia virus infected in HEL cells assessed as inhibition of virus-induced cytopathicity	2016	Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21	First discovery of novel 3-hydroxy-quinazoline-2,4(1H,3H)-diones as specific anti-vaccinia and adenovirus agents via 'privileged scaffold' refining approach.
AID1402828	Antiviral activity against HSV2 strain G infected in HEL cells assessed as reduction in virus-induced cytopathic effect after 2 to 3 days	2018	European journal of medicinal chemistry, Jan-20, Volume: 144	Emimycin and its nucleoside derivatives: Synthesis and antiviral activity.
AID246614	Effective concentration required to inhibit human cytomegalo virus Davis induced cytopathicity in HEL fibroblast cell line after 7 days of postinfection	2005	Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7	From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors.
AID634835	Antiviral activity against Felid herpesvirus 1 infected in CrFK cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID96824	Inhibitory activity against L1210 cell line	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID3058	Antiviral activity against 07/1 strain of thymidine kinase negative (TK-) Varicella-Zoster Virus (VZV)	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID275073	Antiviral activity against para influenza 3 virus in Vero cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID416776	Antiviral activity against VSV in human HEL cells assessed as protection against virus-induced cytopathicity	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID383521	Antiviral activity against thymidine kinase deficient and acyclovir resistant HSV1 KOS in human HEL cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID429198	Antiviral activity against thymidine kinase deficient Varicella zoster virus 07/1 infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 5 days	2009	European journal of medicinal chemistry, Aug, Volume: 44, Issue:8	Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl}guanine analogues.
AID87505	Minimum inhibitory concentration required to reduce HSV-1 (McIntyre) strain-induced cytopathogenicity in primary rabbit kidney cell cultures	1981	Journal of medicinal chemistry, Jun, Volume: 24, Issue:6	Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID83896	Minimum inhibitory concentration required to reduce herpes simplex virus-1 (HSV-1 (KOS)) virus-induced cytopathicity by 50%	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID1854961	Antiviral activity against HSV-1 KOS infected in HEL cells assessed as reduction in virus-induced cytopathic effect by microscopic analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Synthesis and antiviral properties of biomimetic iminosugar-based nucleosides.
AID63780	The compound was tested for its antiviral activity against HSV-1 (KOS) virus in E6SM cell line	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID30875	Antiherpes activity was tested as percent of control of plaque-formation against ACG (Tr7) virus by 30 uM of the compound	1985	Journal of medicinal chemistry, Jul, Volume: 28, Issue:7	Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID687662	Antiviral activity against HSV2 G infected in HEL assessed as inhibition of virus-induced cytopathicity after 3 days	2012	European journal of medicinal chemistry, Nov, Volume: 57	Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4'-phosphono-but-2'-en-1'-yl]purine nucleosides.
AID246316	Effective concentration required to reduce HSV-1 strain KOS virus plaque formation by 50% in E6SM Cell Culture	2004	Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22	6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains.
AID303230	Antiviral activity against Coxsackie virus B4 in HeLa cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID634753	Antiviral activity against thymidine kinase-positive Varicella Zoster virus Oka infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID64110	Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus TK- HSV-1 (B2006) was measured	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID607913	Antiviral activity against Varicella-zoster virus YS expressing thymidine kinase infected in human HEL cells assessed as reduction in the virus plaque formation	2011	Bioorganic & medicinal chemistry, Jul-15, Volume: 19, Issue:14	Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
AID228733	Minimum cytotoxic concentration which causes microscopically detectable alteration of normal cell morphology after 2 days of incubation.	1997	Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4	Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.
AID64088	Concentration required to inhibit HSV-2(G) induced cytopathogenicity in E6SM cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID217497	Effective concentration to show 50% of activity was measured on varicella zoster virus(VZV) cell culture	2000	Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13	Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses.
AID221798	Compound was tested for antitumor activity against human B-lymphoblast Raji/0 cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID147625	Antiviral activity against OKA strain of thymidine kinase positive(TK+) Varicella-Zoster Virus (VZV)	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID66771	The compound was tested for its antiviral activity against vaccinia virus in E6SM cell culture	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID687664	Antiviral activity against VZV OKA expressing thymidine kinase infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 3 days	2012	European journal of medicinal chemistry, Nov, Volume: 57	Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4'-phosphono-but-2'-en-1'-yl]purine nucleosides.
AID218510	Effective concentration required to reduce parainfluenza-3-induced cytopathicity in vero cells	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID66764	The compound was tested for its antiviral activity against HSV-1 (F) virus in E6SM cell culture	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID1462037	Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID1869615	Cytotoxicity against human HEL cells assessed as reduction in cell growth measured after 3 days by coulter counting method	2022	Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13	Reshaping an Acyclic Nucleoside Phosphonate into a Selective Anti-hepatitis B Virus Compound.
AID634760	Antiviral activity against Vesicular stomatitis virus infected in human Hela cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID1854969	Antiviral activity against Human adenovirus 2 infected in HEL cells assessed as reduction in virus-induced cytopathic effect by microscopic analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Synthesis and antiviral properties of biomimetic iminosugar-based nucleosides.
AID66799	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 50 ug/mL of 6-aminothymine	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID81201	Minimum inhibitory concentration required to reduce virus induced plaque formation in HEL cell culture of virus CMV (AD169) was measured	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID675219	Antiviral activity against Feline herpesvirus infected in CRFK cells by viral CPE assay	2012	European journal of medicinal chemistry, Sep, Volume: 55	Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
AID416774	Antiviral activity against HSV2 G in human HEL cells assessed as protection against virus-induced cytopathicity	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID167133	Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against HSV-1 ((KOS)	1983	Journal of medicinal chemistry, Apr, Volume: 26, Issue:4	Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID393980	Antiviral activity against thymidine kinase deficient Varicella zoster virus 07/1 infected in human HEL cells assessed reduction in viral plaque formation	2009	Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6	4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus.
AID297317	Antiviral activity against RSV in HeLa cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID209530	Minimum inhibitory concentration required to reduce thymidine kinase deficient-HSV-1 (B2006) virus-induced cytopathicity by 50%	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID521220	Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay	2007	Nature chemical biology, May, Volume: 3, Issue:5	Chemical genetics reveals a complex functional ground state of neural stem cells.
AID66791	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 100 ug/mL of dUrd and 50 ug/mL of 6-aminothymine	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID81371	Inhibitory dose for HELF cell proliferation during 3-day treatment period	1988	Journal of medicinal chemistry, Feb, Volume: 31, Issue:2	Synthesis and biological activities of 4-O-(difluoromethyl)-5-substituted-uracil nucleoside analogues.
AID1610153	Cytotoxicity against human HELF cells assessed as minimum cytotoxic concentration by observing alteration in cell morphology incubated for 3 days by microscopic analysis	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID1498130	Cytotoxicity against HEL cells assessed as alteration of cell morphology by microscopic analysis	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.
AID216169	Minimum Inhibition Concentration (MIC) for activity against Varicella-Zoster Virus(VZV) using 07/1 (TK-) strain.	1996	Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14	Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.
AID1394849	Antiviral activity against thymidine kinase-deficient ACV-resistant Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of plaque formation measured after 2 to 3 days post infection	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates.
AID429197	Antiviral activity against Varicella zoster virus OKA infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 5 days	2009	European journal of medicinal chemistry, Aug, Volume: 44, Issue:8	Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl}guanine analogues.
AID63766	The minimum inhibitory concentration was measured on E6SM cells against Vaccinia virus	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID85129	Minimum inhibitory concentration was determined against HSV-2 (Lyons) in E6SM cell culture	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID257891	Antiviral activity against Vaccinia virus in HEL cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID257894	Antiviral activity against Parainfluenza-3 virus in vero cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID246529	Effective concentration required to reduce TK+ (thymidine kinase presence) VZV strain OKA virus plaque formation by 50% in HEL cell culture	2004	Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22	6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains.
AID63595	Minimum inhibitory conc. for 50% inhibition of HSV-2 (196) virus induced cytopathicity in E6SM cells	1997	Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9	Carbocyclic oxetanocins lacking the C-3' methylene.
AID291034	Antiviral activity against reovirus1 virus in Vero cells assessed as reduction of virus plaque formation after 7 days	2007	Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13	Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
AID83201	Minimum inhibitory concentration to reduce cytopathicity by 50% in proliferation of human embryonic lung cells (HEL)	1994	Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9	Synthesis and antiviral activities of 8-alkynyl-, 8-alkenyl-, and 8-alkyl-2'-deoxyadenosine analogues.
AID154154	Cytotoxic concentration for the inhibition of P3HR-1 cell growth	2002	Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23	CycloSal-BVDUMP pronucleotides: how to convert an antiviral-inactive nucleoside analogue into a bioactive compound against EBV.
AID66018	Compound was evaluated for the minimum inhibition concentration required to reduce virus-induced cytopathogenicity by 50%, determined against HSV-1 (TK-B2006) virus	1998	Journal of medicinal chemistry, Oct-22, Volume: 41, Issue:22	5-Substituted pyrimidines with a 1,5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase.
AID161450	Minimum cytotoxic concentration required to cause a microscopically detectable alteration of rabbit kidney cell morphology	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID85713	Antiviral activity against Herpes Simplex Virus-1 (KOS)	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID218050	Minimum inhibitory concentration required to reduce cytopathogenicity of Herpes Virus-2 (HSV-2) in vero cells by 50%.	1991	Journal of medicinal chemistry, Sep, Volume: 34, Issue:9	The synthesis and antiviral activity of some 4'-thio-2'-deoxy nucleoside analogues.
AID83024	Tested for the inhibitory concentration required to reduce thymidine kinase deficient Varicella-Zoster virus (TK- VZV) strain YS/R plaque formation by 50%.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID84591	Minimal inhibitory concentration to reduce virus-induced cytopathicity against McIntyre strain of human Herpes Simplex Virus-1	2001	Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24	Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study.
AID388920	Antiviral activity against human cytomegalovirus AD169 in HEL cells assessed as inhibition of viral cytopathicity	2008	Bioorganic & medicinal chemistry, Nov-01, Volume: 16, Issue:21	Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): part II.
AID675214	Antiviral activity against HSV1 KOS infected in HEL cells by viral CPE assay	2012	European journal of medicinal chemistry, Sep, Volume: 55	Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
AID217983	Compound was evaluated for its antiviral activity against vaccinia	1984	Journal of medicinal chemistry, Mar, Volume: 27, Issue:3	Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.
AID88297	Evaluated for minimum inhibitory concentration against G,196, Lyons strains of Herpes simplex virus (HSV-2) in primary rabbit kidney cells	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one.
AID217995	Antiviral activity against vaccinia virus	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID658756	Antiviral activity against thymidine kinase-deficient VSV 07-1 infected in HEL cells assessed as reduction of virus plaque formation after 4 days	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID161456	Antiviral activity against Lyons strain of herpes simplex virus-2 in primary rabbit kidney cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID224703	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 250 mg/kg at day 0	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID86514	The compound was tested for its antiviral activity against HSV-1 (KOS) virus in HeLa cell line	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID275086	Antiviral activity against HSV1 KOS in HEL cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID246356	Effective concentration required to reduce HSV-1 strain KOS ACV virus plaque formation by 50% in E6SM Cell Culture	2004	Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22	6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains.
AID1113466	Antiviral activity against acyclovir-resistant thymidine kinase negative Human herpesvirus 1 strain KOS infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID260293	Cytotoxicity as determined by alteration in the cell morphology of HEL cells	2006	Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4	Inactivation of S-adenosyl-L-homocysteine hydrolase by 6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine and 6'-chloro-6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine. Antiviral and cytotoxic effects.
AID1394848	Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of plaque formation measured after 2 to 3 days post infection	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates.
AID611619	Antiviral activity against VZV 07/1 infected in HEL cells assessed as protection against virus-induced cytopathicity	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	New prodrugs of Adefovir and Cidofovir.
AID280196	Antiviral activity against RSV Long in HeLa cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID1113468	Antiviral activity against Vaccinia virus infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID83328	The minimum inhibitory concentration was measured on HEL cells against TK-Varicella zoster virus (07/1 strain)	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID1462032	Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID296673	Antiviral activity against TK+ VZV OKA in HEL cells assessed as reduction of virus plaque formation after 5 days	2007	Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16	Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.
AID1328759	Cytostatic activity against thymidine kinase deficient human HeLa cells after 3 days by cell counting method	2016	Bioorganic & medicinal chemistry letters, 12-01, Volume: 26, Issue:23	ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites.
AID161453	Antiviral activity against F strain of herpes simplex virus-1 in primary rabbit kidney cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID258990	Antiviral activity against Varicella-Zoster virus 07/1 strain	2006	Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1	Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivatives.
AID687660	Antiviral activity against Vaccinia virus infected in HEL assessed as inhibition of virus-induced cytopathicity after 3 days	2012	European journal of medicinal chemistry, Nov, Volume: 57	Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4'-phosphono-but-2'-en-1'-yl]purine nucleosides.
AID275074	Antiviral activity against reovirus 1 in Vero cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID65707	Antiviral activity against Vaccinia virus in E6SM cell cultures	2001	Journal of medicinal chemistry, Aug-02, Volume: 44, Issue:16	Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
AID220080	Antiviral activity against YS/R strain of thymidine kinase negative(TK-) Varicella-Zoster Virus (VZV)	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID82854	Compound was evaluated for the anti-viral activity against HEL cells	1999	Journal of medicinal chemistry, Nov-04, Volume: 42, Issue:22	Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base.
AID1854964	Antiviral activity against Human cytomegalovirus AD-169 infected in HEL cells assessed as reduction in virus-induced cytopathic effect by microscopic analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Synthesis and antiviral properties of biomimetic iminosugar-based nucleosides.
AID66941	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against TK- HSV-1 virus in E6SM cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID244771	Concentration required to cause a microscopically visible alteration of cell morphology in HEL cells	2005	Journal of medicinal chemistry, Jul-14, Volume: 48, Issue:14	Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.
AID286287	Cytotoxicity against DG75 cells after 120 hrs by MTT assay	2007	Journal of medicinal chemistry, May-03, Volume: 50, Issue:9	9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus.
AID81046	In vitro antiviral activity and cytotoxicity, and minimum inhibitory concentration required to reduce cell growth by 50% in HEL cell culture	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID165543	Inhibitory activity against incorporation of deoxy-[methyl.3H-]-thymidine (dThd) into the DNA of uninfected primary rabbit kidney (PRK) cell cultures	1983	Journal of medicinal chemistry, May, Volume: 26, Issue:5	Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.
AID63615	Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-1) strain F induced cytopathogenicity by 50%.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID64118	Tested for minimum inhibitory concentration against HSV-1 (KOS strain) in E6SM cells	1993	Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20	Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents.
AID216171	Minimum Inhibition Concentration (MIC) for activity against Varicella-Zoster Virus(VZV) using YS(TK+) strain.	1996	Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14	Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.
AID434320	Cytotoxicity against HEL cells assessed as change in cell morphology	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID434316	Antiviral activity against Reovirus 1 infected in african green monkey Vero cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID304882	Antiviral activity against TK+ VZV OKA in HEL cells after 5 days	2007	Journal of medicinal chemistry, Dec-27, Volume: 50, Issue:26	Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines.
AID388918	Antiviral activity against thymidine kinase expressing Varicella-Zoster virus Oka in HEL cells assessed as inhibition of viral cytopathicity	2008	Bioorganic & medicinal chemistry, Nov-01, Volume: 16, Issue:21	Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): part II.
AID383520	Antiviral activity against thymidine kinase deficient and acyclovir resistant HSV1 KOS in human E6SM cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID216382	Concentration required to reduce vesicular stomatitis virus induced cytopathogenicity in rabbit cell kidney culture	1988	Journal of medicinal chemistry, Jan, Volume: 31, Issue:1	Synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2'-deoxycytidine-related compounds.
AID296677	Antiviral activity against HCMV Davis in HEL cells assessed as reduction of virus plaque formation after 7 days	2007	Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16	Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.
AID85719	Concentration required to reduce HSV-1 virus induced cytopathogenicity in rabbit cell kidney culture (KOS cells)	1988	Journal of medicinal chemistry, Jan, Volume: 31, Issue:1	Synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2'-deoxycytidine-related compounds.
AID383524	Antiviral activity against Punta Toro virus in african green monkey Vero cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID167138	Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against HSV-2 (Lycons)	1983	Journal of medicinal chemistry, Apr, Volume: 26, Issue:4	Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID209372	Compound was tested for antitumor activity against HSV-1 TK gene transformed TK deficient FM3A cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID275089	Cytotoxicity against Vero cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID218251	Evaluation for antiviral activity against Coxsackie virus B4 in Vero cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID216472	Antiviral activity was tested against TK- Varicella-Zoster virus 07/1 which reduces virus plaque formation by 50%	2002	Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19	Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles.
AID228729	Minimal cytotoxic concentration (MCC) to cause a microscopically detectable change in normal cell morphology	2001	Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24	Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study.
AID83023	Tested for the inhibitory concentration required to reduce thymidine kinase deficient Varicella-Zoster virus (TK- VZV) strain 07/1 plaque formation by 50%.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID87144	Tested for cytotoxic activity in human epithelial cell line (HeLa)	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID216040	Inhibitory activity against herpes simplex virus type 2 (HSV 2) strain 186 in Vero cells.	1996	Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3	Synthesis and anti-herpes virus activity of 2'-deoxy-4'-thiopyrimidine nucleosides.
AID209537	Minimum inhibitory concentration required to reduce TK-VZV (YS/R) virus-induced cytopathicity by 50%	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID120301	In vivo evaluation for the percent survivors in systemic HSV-1 infection of Mice administered through oral route at a dose 10 mg/kg per day; NT=Not tested	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID482703	Antiviral activity against HSV2 G infected in human E6SM cell assessed as inhibition of virus-induced cytopathicity	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	"Viologen" dendrimers as antiviral agents: the effect of charge number and distance.
AID675221	Cytotoxicity against HEL cells assessed as effect on cell morphology incubated for 3 days by microscopy	2012	European journal of medicinal chemistry, Sep, Volume: 55	Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
AID1572729	Antiviral activity against herpes simplex virus 1 KOS infected in HEL cells assessed as reduction in virus-induced cytopathogenicity by microscopic analysis	2019	Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6	Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID768201	Antiviral activity against Vesicular stomatitis virus infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID217768	Inhibitory dose required to reduce the viability of vero cells by 50%	1991	Journal of medicinal chemistry, Sep, Volume: 34, Issue:9	The synthesis and antiviral activity of some 4'-thio-2'-deoxy nucleoside analogues.
AID45932	Inhibitory concentration against CMV strain Davis in human embryonic lung (HEL) cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID1402825	Antiviral activity against TK-defecient VZV 07-1 infected in HEL cells assessed as reduction in plaque formation after 5 days	2018	European journal of medicinal chemistry, Jan-20, Volume: 144	Emimycin and its nucleoside derivatives: Synthesis and antiviral activity.
AID81051	Concentration required to inhibit CMV (AD-169) induced cytopathogenicity in HEL cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID87503	Minimum inhibitory concentration required to reduce HSV-1 (F) strain-induced cytopathogenicity in primary rabbit kidney cell cultures	1981	Journal of medicinal chemistry, Jun, Volume: 24, Issue:6	Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID81026	The compound was tested for antiviral activity by measuring the concentration required to reduce plaque formation against Varicella zoster TK+OKA strain	1999	Journal of medicinal chemistry, Jul-15, Volume: 42, Issue:14	Novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis and biological evaluation.
AID297307	Antiviral activity against thymidine kinase deficient VZV 07/1 in human HEL cells after 7 days	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID383508	Antiviral activity against Coxsackie virus B4 in human HeLa cells assessed as inhibition of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID81205	Minimum inhibitory concentration required to reduce virus induced plaque formation in HEL cell culture of virus VZS (OKA) was measured	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID1409613	Selectivity ratio: ratio of AUC (viral infection %) of SARS-CoV-2 in the Vero E6 cell line compared to AUC (cytotoxicity %) of compound against Vero E6 cells by MTT assay.	2020	Nature, 07, Volume: 583, Issue:7816	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
AID246524	Concentration required to inhibit human immunodeficiency virus-1 (strain ROD) induced cytopathogenicity in CEM cells by 50%	2005	Journal of medicinal chemistry, Jul-14, Volume: 48, Issue:14	Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.
AID66785	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 10 ug/mL of dUrd	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID1328756	Cytostatic activity against human CD4-positive CEM cells after 3 days by cell counting method	2016	Bioorganic & medicinal chemistry letters, 12-01, Volume: 26, Issue:23	ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites.
AID1572731	Antiviral activity against thymidine kinase deficient and aciclovir resistant herpes simplex virus 1 KOS infected in HEL cells assessed as reduction in virus-induced cytopathogenicity by microscopic analysis	2019	Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6	Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID246451	Concentration required to inhibit human cytomegalovirus strain Davis induced cytopathogenicity in HEL cells by 50%	2005	Journal of medicinal chemistry, Jul-14, Volume: 48, Issue:14	Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.
AID768200	Antiviral activity against TK-negative Herpes simplex virus 1 KOS infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID218369	Cytotoxic concentration required to cause microscopically detectable alteration of normal cell morphology of Vero cells	1996	Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14	Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.
AID284533	Antiviral activity against HSV1 TK- KOS ACV-induced cytopathogenicity in E6SM cells	2007	Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2	The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
AID1402830	Cytotoxicity against HEL cells assessed as alteration in cell morphology after 3 days by microscopic method	2018	European journal of medicinal chemistry, Jan-20, Volume: 144	Emimycin and its nucleoside derivatives: Synthesis and antiviral activity.
AID90760	50% effective concentration required to reduce cytomegalovirus (CMV AD-169 strain)-induced cytopathicity	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID85119	Effective concentration to show 50% of activity was measured on herpes simplex virus-2 333 strain cell culture.	2000	Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13	Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses.
AID1684813	Cytotoxicity against human HEL cells assessed as alteration in cell morphology incubated for 3 days by microscopic analysis	2021	ACS medicinal chemistry letters, Jan-14, Volume: 12, Issue:1	Influence of 4'-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2.
AID257896	Antiviral activity against Sindbis virus in vero cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID1337436	Cytotoxicity against HEL cells assessed as growth inhibition after 3 days by coulter counter method	2016	European journal of medicinal chemistry, Nov-29, Volume: 124	Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor.
AID87508	Evaluation of antiviral activity against Herpes simplex virus type 1 (HSV-1) strain McIntyre	1986	Journal of medicinal chemistry, Jul, Volume: 29, Issue:7	Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID634836	Antiviral activity against Feline coronavirus infected in CrFK cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID482714	Antiviral activity against Punta Toro virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathicity	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	"Viologen" dendrimers as antiviral agents: the effect of charge number and distance.
AID63954	Concentration required to inhibit HSV-1 (F) induced cytopathogenicity in E6SM cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID1684817	Antiviral activity against thymidine kinase positive Varicella zoster virus OKA infected in human HEL cells assessed as reduction in virus plaque formation measured on day 5 post-viral infection	2021	ACS medicinal chemistry letters, Jan-14, Volume: 12, Issue:1	Influence of 4'-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2.
AID768202	Antiviral activity against Vaccinia virus infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID161460	Antiviral activity against Vesicular stomatitis virus in primary rabbit kidney cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID84238	50% effective concentration required to reduce herpes simplex virus-1 (HSV- (TK-) B2006 strain)-induced cytopathicity	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID217485	Minimum inhibitory concentration required to reduce vesicular somatitis virus (VSV (YS)) virus-induced cytopathicity by 50%	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID83333	The minimum inhibitory concentration was measured on HEL cells in cell growth	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID64091	Concentration required to inhibit TK-HSV-1 (VMW1837) induced cytopathogenicity in E6SM cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID120294	In vivo evaluation for the percent survivors in systemic HSV-1 infection of Mice administered through intraperitoneal at a dose 100 mg/kg per day	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID280186	Cytotoxicity against HEL cells assessed as alteration in cell morphology after 3 days	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID675212	Antiviral activity against thymidine kinase negative VZV 07/01 infected in HEL cells by plaque formation assay	2012	European journal of medicinal chemistry, Sep, Volume: 55	Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
AID87478	Tested for in vitro anti-HSV-1 activity; active	1990	Journal of medicinal chemistry, Feb, Volume: 33, Issue:2	Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.
AID88117	Minimum inhibitory concentration causing 50% inhibition of cytopathic effect induced by HSV-2 in PRK cells	1988	Journal of medicinal chemistry, Sep, Volume: 31, Issue:9	Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
AID246312	Effective concentration required to reduce CMV davis strain virus plaque formation by 50% in HEL cell culture	2004	Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22	6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains.
AID66774	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in absence of dThd	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID63746	Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (TK- / TK+ HSV-1) strain VMW-1837 induced cytopathogenicity by 50%.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID218376	Evaluation for antiviral activity against reo virus-1 in Vero cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID84769	Concentration required to reduce HSV-2 virus induced cytopathogenicity in rabbit cell kidney culture (Lyons cells)	1988	Journal of medicinal chemistry, Jan, Volume: 31, Issue:1	Synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2'-deoxycytidine-related compounds.
AID66776	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence 0 ug/mL of 50 ug/mL of 6-aminothymine	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID167136	Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against HSV-2 (196)	1983	Journal of medicinal chemistry, Apr, Volume: 26, Issue:4	Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID1402823	Antiviral activity against HCMV Davis infected in HEL cells assessed as reduction in virus-induced cytopathic effect after 6 to 7 days	2018	European journal of medicinal chemistry, Jan-20, Volume: 144	Emimycin and its nucleoside derivatives: Synthesis and antiviral activity.
AID68120	Concentration required to reduce HSV-1 thymidine kinase deficient (TK-)(VMW 1837) induced cytopathogenicity in by 50% ESM(embryonic skin muscle) cell cultures.	1992	Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12	(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties.
AID66782	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 10 ug/mL dThd	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID83181	Concentration required to reduce VZV-07/1-TK- plaque formation by 50% in human embryonic lung (HEL) cell cultures.	1992	Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12	(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties.
AID165528	Concentration required to reduce Vaccinia virus induced cytopathogenicity in primary rabbit kidney (PRK) cell cultures	1983	Journal of medicinal chemistry, May, Volume: 26, Issue:5	Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.
AID1410509	Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as inhibition of virus-induced cytopathic effect measured after 6 to 7 days post-infection	2018	ACS medicinal chemistry letters, Apr-12, Volume: 9, Issue:4	Amidate Prodrugs of Cyclic 9-(
AID257892	Antiviral activity against Vesicular stomatitis virus in HEL cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID1328755	Cytostatic activity against thymidine kinase deficient mouse L1210 cells after 2 days by cell counting method	2016	Bioorganic & medicinal chemistry letters, 12-01, Volume: 26, Issue:23	ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites.
AID309815	Cytotoxicity against HEL cells assessed as reduction of cell growth after 3 days	2007	Bioorganic & medicinal chemistry, Nov-15, Volume: 15, Issue:22	Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV).
AID235555	Ratio of Cytotoxicity concentration to that of virus-inhibitory concentration;d ='not determined'.	1998	Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25	Synthesis of imidazo[1,2-a]pyridines as antiviral agents.
AID224701	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 25 mg/kg at day 6	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID224698	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 25 mg/kg at day 12	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID1854962	Antiviral activity against HSV-2 G strain infected in HEL cells assessed as reduction in virus-induced cytopathic effect by microscopic analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Synthesis and antiviral properties of biomimetic iminosugar-based nucleosides.
AID84763	Antiviral activity against Herpes Simplex Virus-2(196)	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	Synthesis and antitumor and antiviral properties of 5-alkyl-2'-deoxyuridines, 3',5'-cyclic monophosphates, and neutral cyclic triesters.
AID1610165	Antiviral activity against Herpes simplex virus 1 TK-KOS-ACV infected in human HELF cells assessed as reduction in virus-induced cytopathogenicity incubated for 7 days by microscopic analysis	2019	European journal of medicinal chemistry, Dec-15, Volume: 184	Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
AID280194	Antiviral activity against coxsackie B4 virus in HeLa cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID87844	Antiviral activity against herpes simplex type-1 expressed as ED90	1985	Journal of medicinal chemistry, Jun, Volume: 28, Issue:6	Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents.
AID66797	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 300 ug/mL dThd	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID216166	Minimum inhibitory concentration which is active against Varicella zoster virus (VZV); value ranges from 0.0002-0.003 ug/mL	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and antiviral activity of 3'-deoxy-3'-C-hydroxymethyl nucleosides.
AID217975	50% effective concentration required to reduce vaccinia virus-induced cytopathicity	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID297310	Cytotoxicity against human HEL cells assessed as alteration in cell morphology	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID30872	Antiherpes activity was tested as percent of control of plaque-formation against ACG (S1) virus by 30 uM of the compound	1985	Journal of medicinal chemistry, Jul, Volume: 28, Issue:7	Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID768203	Antiviral activity against Herpes simplex virus-2 G infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID288915	Cytotoxicity against E6SM cells assessed as alteration in cell morphology	2007	Journal of medicinal chemistry, Jun-14, Volume: 50, Issue:12	5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
AID217998	Evaluated for minimum inhibitory concentration against Vaccinia virus (VV) in primary rabbit kidney cells	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one.
AID41208	The compound was tested for its antiviral activity against HSV-1 (KOS) virus in BALB/3T3 cell line	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID217890	Evaluated for minimum inhibitory concentration against Vero cells (African green monkey) infected with PV-3, RV-1, SV, Coxs B4, SFV virus	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one.
AID539916	Antiviral activity against Herpes simplex virus-2 G infected in human HEL cells assessed as protection against virus-induced cytopathogenicity after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID303231	Antiviral activity against Coxsackie virus B4 in Vero cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID63625	Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-2) strain Lyons induced cytopathogenicity by 50%.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID87504	Minimum inhibitory concentration required to reduce HSV-1 (KOS) strain-induced cytopathogenicity in primary rabbit kidney cell cultures	1981	Journal of medicinal chemistry, Jun, Volume: 24, Issue:6	Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID1457766	Antiviral activity against HCMV Davis strain infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	2017	Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14	Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
AID1427828	Cytotoxicity against HEL cells infected with Varicella-Zoster virus assessed as growth inhibition
AID553340	Antiviral activity against Vaccinia virus infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days	2011	Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1	Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.
AID634837	Antiviral activity against Human immunodeficiency virus 2 infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopic analysis	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID1498114	Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as inhibition of virus-induced cytopathicity	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.
AID224691	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 100 mg/kg at day 0	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID216156	Effective concentration against TK- Varicella-Zoster Virus (VZV) YS/R strain	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID66940	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against HSV-2 virus in E6SM cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID81193	Inhibitory concentration required to inhibit cell growth by 50% in human embryonic lung (HEL) cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID64093	Concentration required to inhibit VSV induced cytopathogenicity in E6SM cells by 50%.	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID768205	Antiviral activity against TK-positive Varicella-zoster virus 07-1 infected in human HEL cells assessed as reduction of plaque formation	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID72048	Compound was tested for antitumor activity against FM3A/TK- cells	1987	Journal of medicinal chemistry, Aug, Volume: 30, Issue:8	Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID216154	Effective concentration against TK+ Varicella-Zoster Virus (VZV)YS strain	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID66768	The compound was tested for its antiviral activity against HSV-2 (G) virus in E6SM cell culture	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID83199	Minimum inhibitory concentration required for antiviral activity to reduce Varicella Zoster virus (VZV) (Oka) induced cytopathicity in human embryonic lung cells (HEL)	1994	Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9	Synthesis and antiviral activities of 8-alkynyl-, 8-alkenyl-, and 8-alkyl-2'-deoxyadenosine analogues.
AID1422439	Antiviral activity against Human herpesvirus 2 strain G infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by microscopic method	2018	Bioorganic & medicinal chemistry letters, 11-15, Volume: 28, Issue:21	Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents.
AID235593	Ratio of ID50/ID90 in HSV-1 infected cells	1985	Journal of medicinal chemistry, Jun, Volume: 28, Issue:6	Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents.
AID63754	Tested for the minimum inhibitory concentration required to reduce vaccinia virus(VV) induced cytopathogenicity by 50%.	1995	Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5	Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID383528	Antiviral activity against TK- VZV 07/1 infected HEL cells assessed as reduction in virus plaque formation	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID634752	Antiviral activity against Human cytomegalovirus Davis infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID383506	Cytotoxicity against human HeLa cells	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID224706	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 250 mg/kg at day 3	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID246561	Effective concentration required to reduce TK+ (thymidine kinase deficient) VZV strain 07/1 virus plaque formation by 50% in HEL cell culture	2004	Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22	6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains.
AID218249	Evaluation in Vero cell cultures for cytotoxicity that is to cause microscopically detectable alteration of normal cell morphology	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID297311	Cytotoxicity against human HEL cells assessed as reduction of cell growth	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID45815	The mitochondrial toxicity was measured on human T-lymphoid CEM cells.	2000	Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13	Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses.
AID1230100	Antiviral activity against Varicella-zoster virus expressing thymidine kinase infected in HEL cells assessed as reduction of virus-induced plaque formation	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues.
AID280175	Antiviral activity against HSV1 KOS in HEL cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID383512	Antiviral activity against HSV1 KOS in human E6SM cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID209531	Minimum inhibitory concentration required to reduce thymidine kinase deficient-HSV-1 (VMW 1837) virus-induced cytopathicity by 50%	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID634758	Antiviral activity against Coxsackievirus B4 infected in african green monkey Vero cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID607914	Antiviral activity against Varicella-zoster virus OKA expressing thymidine kinase infected in human HEL cells assessed as reduction in the virus plaque formation	2011	Bioorganic & medicinal chemistry, Jul-15, Volume: 19, Issue:14	Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
AID539919	Antiviral activity against acyclovir-resistant TK deficient Herpes simplex virus-1 KOS infected in human HEL cells assessed as protection against virus-induced cytopathogenicity after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID83193	Minimum inhibitory conc. for 50% inhibition of VZV (OKA) virus plaque formation in HEL cells	1997	Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9	Carbocyclic oxetanocins lacking the C-3' methylene.
AID106003	Inhibitory activity against varicella zoster virus (VZV) strain G31 in MRC-5 cells.	1996	Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3	Synthesis and anti-herpes virus activity of 2'-deoxy-4'-thiopyrimidine nucleosides.
AID303228	Antiviral activity against VSV in HEL cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID246415	Concentration required to inhibit herpes simplex virus type 2 induced cytopathogenicity in HEL cells by 50%	2005	Journal of medicinal chemistry, Jul-14, Volume: 48, Issue:14	Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.
AID658754	Cytotoxicity against human HeLa cells assessed as cell viability by colorimetric formazan-based MTS assay	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID232771	Selectivity index against HSV-2 was determined as CD50/ED50 ratio	1994	Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1	S-glucosylated hydantoins as new antiviral agents.
AID87146	Evaluation for antiviral activity against Coxsackie virus B4 in HeLa cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID303237	Cytotoxicity against HeLa cells assessed as alteration in morphology after 3 days	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID434309	Antiviral activity against Vaccinia virus infected in human HEL cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID85558	Concentration required to reduce cytopathogenicity of Herpes simplex virus type 1 (strain KOS) by 50% in primary rabbit kidney (PRK) cells	1984	Journal of medicinal chemistry, Nov, Volume: 27, Issue:11	Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID120305	In vivo evaluation for the percent survivors in systemic HSV-1 infection of Mice administered through oral route at a dose 5 mg/kg per day	1985	Journal of medicinal chemistry, Nov, Volume: 28, Issue:11	5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID125368	Inhibitory activity against Molt/4F cell line	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.
AID383513	Antiviral activity against HSV1 KOS in human HEL cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID64107	Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-2 (196) was measured.	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
AID27595	Partition coefficient (logP)	2002	Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23	CycloSal-BVDUMP pronucleotides: how to convert an antiviral-inactive nucleoside analogue into a bioactive compound against EBV.
AID224705	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 250 mg/kg at day 20	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID687666	Cytotoxicity against HEL assessed as minimum compound concentration causes microscopically detectable alteration of cell morphology after 3 days	2012	European journal of medicinal chemistry, Nov, Volume: 57	Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4'-phosphono-but-2'-en-1'-yl]purine nucleosides.
AID1294505	Cytotoxicity against human Ramos cells assessed as reduction in cell viability after 72 hrs by MTS assay	2016	Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9	L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation.
AID464182	Cytotoxicity against acyclovir-sensitive Herpes simplex virus 1 KOS infected HEL cells by trypan blue exclusion method	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID63596	Minimum inhibitory conc. for 50% inhibition of HSV-2 (G) virus induced cytopathicity in E6SM cells	1997	Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9	Carbocyclic oxetanocins lacking the C-3' methylene.
AID296674	Antiviral activity against thymidine kinase deficient VZV 07/1 in HEL cells assessed as reduction of virus plaque formation after 5 days	2007	Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16	Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.
AID83204	Tested for antiviral activity against thymidine kinase deficient Varicella zoster virus in human embryonic lung fibroblasts	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID84605	Concentration required to reduce the number of viral plaques in vivo cell monolayers of herpes simplex virus type 2.	1989	Journal of medicinal chemistry, Feb, Volume: 32, Issue:2	Synthesis and antiviral activity of phosphonoacetic and phosphonoformic acid esters of 5-bromo-2'-deoxyuridine and related pyrimidine nucleosides and acyclonucleosides.
AID68254	Minimum inhibitory concentration required for antiviral activity to reduce TK-HSV-1 (B2006) induced cytopathicity in human embryonic skin-muscle cells (ESM)	1994	Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9	Synthesis and antiviral activities of 8-alkynyl-, 8-alkenyl-, and 8-alkyl-2'-deoxyadenosine analogues.
AID246259	Effective concentration required to reduce vaccinia virus plaque formation by 50% in E6SM Cell Culture	2004	Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22	6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains.
AID65711	Antiviral activity against herpes simplex virus-2 G (HSV-2) in E6SM cell cultures	2001	Journal of medicinal chemistry, Aug-02, Volume: 44, Issue:16	Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
AID611618	Antiviral activity against VZV OKA infected in HEL cells assessed as protection against virus-induced cytopathicity	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	New prodrugs of Adefovir and Cidofovir.
AID1782672	Antiviral activity against thymidine kinase positive Varicella zoster virus	2021	European journal of medicinal chemistry, Aug-05, Volume: 220	Phenoxazine nucleoside derivatives with a multiple activity against RNA and DNA viruses.
AID1294504	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by MTS assay	2016	Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9	L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation.
AID482713	Antiviral activity against Sindbis virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathicity	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	"Viologen" dendrimers as antiviral agents: the effect of charge number and distance.
AID1727354	Cytotoxicity against human HEL cells assessed as concentration required to cause visible alteration in cell morphology incubated for 3 days by coulter counter method	2021	European journal of medicinal chemistry, Jan-01, Volume: 209	Extension of furopyrimidine nucleosides with 5-alkynyl substituent: Synthesis, high fluorescence, and antiviral effect in the absence of free ribose hydroxyl groups.
AID166985	Minimum cytotoxic concentration causing microscopically detectable alteration of normal cell morphology of rabbit kidney cells	1988	Journal of medicinal chemistry, Jan, Volume: 31, Issue:1	Synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2'-deoxycytidine-related compounds.
AID63600	Minimum inhibitory conc. for 50% inhibition of vaccinia virus induced cytopathicity in E6SM cells	1997	Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9	Carbocyclic oxetanocins lacking the C-3' methylene.
AID218518	Antiviral activity against HSV-1 (Herpes simplex virus) in vero cells	1994	Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1	S-glucosylated hydantoins as new antiviral agents.
AID434318	Antiviral activity against Coxsackievirus B4 infected in african green monkey Vero cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID63759	The minimum inhibitory concentration was measured on E6SM cells against Herpes simplex virus type 1 (F strain)	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID275088	Cytotoxicity against HeLa cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID326136	Antiviral activity against Herpes B virus E90-136 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID246474	Concentration required to inhibit Varicella-Zoster virus (strain 07/1) induced cytopathogenicity in HEL cells by 50%	2005	Journal of medicinal chemistry, Jul-14, Volume: 48, Issue:14	Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.
AID224708	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 250 mg/kg at day 9	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID217670	Evaluated for the anti-VZV activity, the concentration of compounds in uM required to reduce VZV TS plaque formation after 5 days in HEL cell cultures compared to untreated controls.	2000	Journal of medicinal chemistry, Dec-28, Volume: 43, Issue:26	Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain.
AID217673	Inhibitory concentration against VZV strain OKA in human embryonic lung (HEL) cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID83196	Minimum inhibitory concentration required for antiviral activity to reduce Cytomegalovirus (CMV) (AD-169) induced cytopathicity in human embryonic lung cells (HEL)	1994	Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9	Synthesis and antiviral activities of 8-alkynyl-, 8-alkenyl-, and 8-alkyl-2'-deoxyadenosine analogues.
AID611620	Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as protection against virus-induced cytopathicity	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	New prodrugs of Adefovir and Cidofovir.
AID84933	Inhibition of viral cytopathic effect in infected human foreskin fibroblast cell in monolayers of HSV-2 AD Vero cells by 50%	2001	Journal of medicinal chemistry, Oct-11, Volume: 44, Issue:21	Synthesis and antiviral activity of novel 5-(1-cyanamido-2-haloethyl) and 5-(1-hydroxy(or methoxy)-2-azidoethyl) analogues of uracil nucleosides.
AID297306	Antiviral activity against thymidine kinase-positive VZV OKA in human HEL cells after 7 days	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID1457767	Antiviral activity against thymidine kinase expressing Varicella-Zoster virus Oka strain assessed as inhibition of plaque formation	2017	Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14	Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
AID81040	Minimum cytotoxic concentration against HEL cell morphology.	2002	Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19	Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles.
AID217496	The effective concentration to show 50% of activity was measured on varicella zoster virus(Ellen) cell culture	2000	Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13	Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses.
AID216350	Tested for antiviral activity against parainfluenza virus in african green monkey kidney cell (Vero)	2002	Bioorganic & medicinal chemistry letters, Mar-11, Volume: 12, Issue:5	New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
AID63758	The minimum inhibitory concentration was measured against Herpes simplex virus type 1 (KOS strain) on E6SM cells	1994	Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19	Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID218252	Evaluation for antiviral activity against forest virus in Vero cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID288920	Antiviral activity against thymidine kinase deficient HSV1 VMW1837 in E6SM cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Jun-14, Volume: 50, Issue:12	5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
AID1394844	Antiviral activity against thymidine kinase expressing Varicella-Zoster virus Oka infected in HEL cells assessed as inhibition of plaque formation measured after 5 days post infection	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates.
AID218253	Evaluation for antiviral activity against Sindbis virus in Vero cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)	1992	Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17	Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID1382170	Selectivity index, ratio of CC50 for HEL cells to EC50 for thymidine kinase deficient Varicella zoster virus 07/1 infected in HEL cells	2018	European journal of medicinal chemistry, Feb-25, Volume: 146	Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.
AID83497	Inhibition of cell proliferation expressed as CC50	1998	Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25	Synthesis of imidazo[1,2-a]pyridines as antiviral agents.
AID210687	Catalytic turnover constant of compound against HSV-1 thymidine kinase; ND denotes not determined	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID63953	Concentration required to cause a microscopically detectable alteration of normal cell morphology in E6SM cells	1991	Journal of medicinal chemistry, Aug, Volume: 34, Issue:8	5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
AID687665	Antiviral activity against thymidine kinase-deficient VZV 07/1 infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 3 days	2012	European journal of medicinal chemistry, Nov, Volume: 57	Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4'-phosphono-but-2'-en-1'-yl]purine nucleosides.
AID246409	Concentration required to inhibit vesicular stomatitis virus induced cytopathogenicity in HEL cells by 50%	2005	Journal of medicinal chemistry, Jul-14, Volume: 48, Issue:14	Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.
AID1684814	Antiviral activity against Human cytomegalovirus Davis infected in human HEL cells assessed as reduction in virus plaque formation measured on 6 to 7 post-viral infection	2021	ACS medicinal chemistry letters, Jan-14, Volume: 12, Issue:1	Influence of 4'-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2.
AID387582	Cytotoxicity against african green monkey Vero cells assessed as alteration in cell morphology by MTS assay	2008	Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18	Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure.
AID228732	Minimum cytotoxic concentration that causes microscopically detectable alterations of cell morphology	2003	Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23	Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID553341	Antiviral activity against HCMV AD169/Davis infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days	2011	Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1	Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.
AID419595	Antiviral activity against VSV infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity after 3 days	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID209536	Minimum inhibitory concentration required to reduce TK-VZV (07-1) virus-induced cytopathicity by 50%	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID1382165	Antiviral activity against Varicella zoster virus Oka infected in HEL cells assessed as reduction in viral plaque formation	2018	European journal of medicinal chemistry, Feb-25, Volume: 146	Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.
AID1462035	Antiviral activity against wild type thymidine kinase-deficient Varicella-Zoster virus 07-1 infected in HEL cells assessed as inhibition of virus-induced plaque formation	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID1382172	Antiviral activity against thymidine kinase deficient acyclovir-resistant Human simplex virus 1 KOS infected in HEL cells assessed as reduction in viral cytopathic effect	2018	European journal of medicinal chemistry, Feb-25, Volume: 146	Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.
AID419593	Antiviral activity against HSV2 G infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity after 3 days	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID326137	Antiviral activity against Herpes simplex virus 1 F infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID284525	Antiviral activity against HSV1 KOS-induced cytopathogenicity in E6SM cells	2007	Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2	The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
AID383511	Cytotoxicity against human HEL cells assessed as alteration of cell morphology	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID297318	Antiviral activity against Reovirus 1 in Vero cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID86215	Antiviral activity against HSV-1 (Brand) in human epithelial (Hep-2) cells	1987	Journal of medicinal chemistry, Jul, Volume: 30, Issue:7	2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID1572733	Antiviral activity against Varicella-zoster virus Oka harboring thymidine kinase infected in HEL cells assessed as reduction in virus plaque formation	2019	Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6	Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID419594	Antiviral activity against Vaccinia virus infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity after 3 days	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID217490	Minimum inhibitory concentration required to reduce vaccinia virus (VV) virus-induced cytopathicity by 50%	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID1427832	Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as reduction in virus-induced cytopathogenicity
AID1409611	AUC (cytotoxicity %) of compound against Vero E6 cells by MTT assay.	2020	Nature, 07, Volume: 583, Issue:7816	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
AID392536	Antiviral activity against Vaccinia virus	2009	Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2	Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
AID87456	Cytotoxicity concentration required to microscopically detectable alteration of cell morphology in HeLa	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID665389	Cytostatic against human HEL cells assessed as reduction in cell growth after 3 days by coulter counter	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and antiviral evaluation of C5-substituted-(1,3-diyne)-2'-deoxyuridines.
AID66796	The concentration required to reduce the cytopathogenicity of HSV-1 (KOS) in E6SM cell culture by 50% in presence of 30 ug/mL dThd	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
AID296676	Antiviral activity against HCMV AD169 in HEL cells assessed as reduction of virus plaque formation after 7 days	2007	Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16	Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.
AID216170	Minimum Inhibition Concentration (MIC) for activity against Varicella-Zoster Virus(VZV) using OKA (TK+) strain	1996	Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14	Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.
AID224700	Survival of mice after intraperitoneal infection with HSV-1 (KOS) and oral administration of 25 mg/kg at day 3	1993	Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5	Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
AID217651	Minimum inhibitory concentration was determined against VZV (TK-07/1) in HEL cells	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
AID66021	Compound was evaluated for the minimum inhibition concentration required to reduce virus-induced cytopathogenicity by 50%, determined against Varicella-Zoster virus (YS)	1998	Journal of medicinal chemistry, Oct-22, Volume: 41, Issue:22	5-Substituted pyrimidines with a 1,5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase.
AID280177	Antiviral activity against HSV2 Lyons in HEL cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID611616	Antiviral activity against acyclovir-resistant Human herpesvirus 1 KOS infected in HEL cells assessed as protection against virus-induced cytopathicity	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	New prodrugs of Adefovir and Cidofovir.
AID1498116	Antiviral activity against Vaccinia virus infected in HEL cells assessed as inhibition of virus-induced cytopathicity	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.
AID665384	Antiviral activity against thymidine kinase-positive Varicella-zoster virus OKA infected in HEL cells assessed as reduction in virus-induced cytopathicity	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and antiviral evaluation of C5-substituted-(1,3-diyne)-2'-deoxyuridines.
AID291035	Antiviral activity against sindbis virus in Vero cells assessed as reduction of virus plaque formation after 7 days	2007	Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13	Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
AID85380	Inhibitory concentration against HSV type 2 strain Lyons in human embryonic skin muscle (ESM) fibroblast cell culture	1993	Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14	Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID257900	Antiviral activity against Coxsackie virus B4 in HeLa cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID432173	Antiviral activity against thymidine kinase-deficient ACV-resistant HSV1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 3 days	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID1361086	Antiviral activity against thymidine kinase expressing Varicella-Zoster virus Oka infected in human HEL cells assessed as reduction in plaque formation after 5 days	2018	European journal of medicinal chemistry, Jul-15, Volume: 155	Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation.
AID217665	Evaluated for the anti-VZV, the concentration of compounds in uM required to reduce VZVTK-07 ( thymidine kinase-deficient strain ) plaque formation after 5 days in HEL cell cultures compared to untreated controls.	2000	Journal of medicinal chemistry, Dec-28, Volume: 43, Issue:26	Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain.
AID217901	Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against measles virus in Vero cells	1992	Journal of medicinal chemistry, Sep-04, Volume: 35, Issue:18	Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.
AID1869610	Antiviral activity against HCMV AD-169 infected in HEL cells assessed as reduction in virus plaque formation	2022	Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13	Reshaping an Acyclic Nucleoside Phosphonate into a Selective Anti-hepatitis B Virus Compound.
AID482706	Antiviral activity against TK-deficient acyclovir-resistant HSV1 KOS infected in human E6SM cell assessed as inhibition of virus-induced cytopathicity	2010	Journal of medicinal chemistry, May-13, Volume: 53, Issue:9	"Viologen" dendrimers as antiviral agents: the effect of charge number and distance.
AID258993	Antiviral activity against human cytomegalovirus Davis strain	2006	Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1	Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivatives.
AID504749	qHTS profiling for inhibitors of Plasmodium falciparum proliferation	2011	Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043	Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1159607	Screen for inhibitors of RMI FANCM (MM2) intereaction	2016	Journal of biomolecular screening, Jul, Volume: 21, Issue:6	A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	226 (45.29)	18.7374
1990's	85 (17.03)	18.2507
2000's	105 (21.04)	29.6817
2010's	72 (14.43)	24.3611
2020's	11 (2.20)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	17 (3.30%)	5.53%
Reviews	38 (7.38%)	6.00%
Case Studies	29 (5.63%)	4.05%
Observational	0 (0.00%)	0.25%
Other	431 (83.69%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Trial			Phase	Enrollment	Study Type	Start Date	Status
A Phase I/II Study Of NB1011 Administered Intravenously Daily For 5 Days Every 4 Weeks In Fluoropyrimidine-Resistant Metastatic Or Relapsed Colorectal Cancers[NCT00031616]			Phase 1/Phase 2	0 participants	Interventional	2001-12-31	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Separating host and microbiome contributions to drug pharmacokinetics and toxicity. Science (New York, N.Y.), 02-08, Volume: 363, Issue: 6427	2019
Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5'-deoxy-5-fluorouridine against adenocarcinoma 755 in mice. Correlation with pharmacokinetics of plasma 5-fluorouracil levels. Biochemical pharmacology, Jun-15, Volume: 38, Issue: 12	1989
Pharmacokinetics of E-5-(2-bromovinyl)-2'-deoxyuridine in mice. Antimicrobial agents and chemotherapy, Volume: 16, Issue: 2	1979
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Article	Year
β-l-1-[5-(E-2-bromovinyl)-2-(hydroxymethyl)-1,3-(dioxolan-4-yl)] uracil (l-BHDU) prevents varicella-zoster virus replication in a SCID-Hu mouse model and does not interfere with 5-fluorouracil catabolism. Antiviral research, Volume: 110	2014
Antivirals for management of herpes zoster including ophthalmicus: a systematic review of high-quality randomized controlled trials. Antiviral therapy, Volume: 17, Issue: 2	2012
Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. Drugs of today (Barcelona, Spain : 1998), Volume: 39, Issue: 5	2003
Herpes zoster guideline of the German Dermatology Society (DDG). Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, Volume: 26, Issue: 3	2003
Treatment of experimental herpes simplex virus encephalitis with (E)-5-(2-bromovinyl)-2'-deoxyuridine in mice. Antimicrobial agents and chemotherapy, Volume: 22, Issue: 3	1982
Oral (E)-5-(2-bromovinyl)-2'-deoxyuridine treatment of severe herpes zoster in cancer patients. European journal of cancer & clinical oncology, Volume: 20, Issue: 4	1984
Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on several parameters of Epstein-Barr virus infection. The Journal of general virology, Volume: 65 ( Pt 1)	1984
E-5-(2-bromovinyl)-2'-deoxyuridine vs. interferon in the systemic treatment of infection with herpes simplex virus of athymic nude mice. The Journal of infectious diseases, Volume: 143, Issue: 6	1981
Combined antiviral effects of acyclovir or bromovinyldeoxyuridine and human immunoglobulin in herpes simplex virus-infected mice. Antiviral research, Volume: 7, Issue: 4	1987
Oral bromovinyldeoxyuridine therapy for herpes simplex and varicella-zoster virus infections in severely immunosuppressed patients: a preliminary clinical trial. Journal of medical virology, Volume: 18, Issue: 1	1986
The chronic toxicity of bromovinyldeoxyuridine in beagle dogs. Fundamental and applied toxicology : official journal of the Society of Toxicology, Volume: 11, Issue: 1	1988
Topical BVDU plus low-dosage steroids in the treatment of chronic relapsing zoster keratouveitis. A pilot study. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, Volume: 227, Issue: 2	1989
Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on life-span and 5-fluorouracil metabolism in mice with hepatic metastases. European journal of cancer (Oxford, England : 1990), Volume: 26, Issue: 10	1990
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

brivudine

Description

Cross-References

Synonyms (82)

Research Excerpts

Overview

Protein Targets (14)

Potency Measurements

Inhibition Measurements

Biological Processes (6)

Molecular Functions (5)

Ceullar Components (2)

Bioassays (1277)

Research

Studies (499)

Study Types

Clinical Trials (1)

Trial Overview

Research Highlights

Safety/Toxicity (6)

Pharmacokinetics (3)

Bioavailability (5)

Dosage (13)

Interactions (6)

Article	Year
Separating host and microbiome contributions to drug pharmacokinetics and toxicity. Science (New York, N.Y.), 02-08, Volume: 363, Issue: 6427	2019
Cytotoxic effects of adenovirus- and lentivirus-mediated expression of Drosophila melanogaster deoxyribonucleoside kinase on Bcap37 breast cancer cells. Oncology reports, Volume: 29, Issue: 3	2013
Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones. European journal of medicinal chemistry, Volume: 45, Issue: 11	2010
(E)-5-(2-bromovinyl)-2'-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase--expressing cells. Cancer gene therapy, Volume: 8, Issue: 5	2001
5-Iodo-2'-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine: selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies. Molecular pharmacology, Volume: 47, Issue: 6	1995
An in vitro study of ophthalmic antiviral agent toxicity on rabbit corneal epithelium. Antiviral research, Volume: 9, Issue: 4	1988
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Article	Year
Efficacy of lentivirus‑mediated Drosophila melanogaster deoxyribonucleoside kinase combined with (E)‑5‑(2‑bromovinyl)‑2'‑deoxyuridine or 1‑β‑D‑arabinofuranosylthymine therapy in human keloid fibroblasts. Molecular medicine reports, Volume: 18, Issue: 2	2018
Potent anticancer effects of lentivirus encoding a Drosophila melanogaster deoxyribonucleoside kinase mutant combined with brivudine. Asian Pacific journal of cancer prevention : APJCP, Volume: 13, Issue: 5	2012
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks. Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue: 2	2009
Effect of acyclovir combined with other antiherpetic agents on varicella zoster virus in vitro. The American journal of medicine, Jul-20, Volume: 73, Issue: 1A	1982
Antiherpes virus activity and effect on deoxyribonucleoside triphosphate pools of (E)-5-(2-bromovinyl)-2'-deoxycytidine in combination with deaminase inhibitors. Antiviral research, Volume: 13, Issue: 3	1990
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Description	Relationhip Strength	Studies	Trials	Classes	Roles
ribavirin	[no description available]	medium	55	0	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide	anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
acyclovir	[no description available]	medium	220	0	2-aminopurines; oxopurine	antimetabolite; antiviral drug
acyclovir	[no description available]	medium	220	7	2-aminopurines; oxopurine	antimetabolite; antiviral drug
ganciclovir	[no description available]	medium	115	0	2-aminopurines; oxopurine	antiinfective agent; antiviral drug
3-deazaaristeromycin	[no description available]	medium	2	0
neplanocin a	[no description available]	medium	1	0
5'-noraristeromycin	[no description available]	medium	1	0
4'-thiothymidine	[no description available]	medium	1	0
zidovudine	[no description available]	medium	15	0	azide; pyrimidine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor
2'-deoxyaristeromycin	[no description available]	medium	1	0
fluorouracil	[no description available]	medium	25	0	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
deoxyuridine	[no description available]	medium	33	0	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
melphalan	[no description available]	medium	3	0	L-phenylalanine derivative; nitrogen mustard; non-proteinogenic L-alpha-amino acid; organochlorine compound	alkylating agent; antineoplastic agent; carcinogenic agent; drug allergen; immunosuppressive agent
5-(2-chloroethyl)-2'-deoxyuridine	[no description available]	medium	8	0	pyrimidine 2'-deoxyribonucleoside
5-(2-iodovinyl)-2'-deoxyuridine	[no description available]	medium	2	0
phosphonoacetic acid	[no description available]	medium	25	0	monocarboxylic acid; phosphonic acids	antiviral agent; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor
phosphonoacetic acid	[no description available]	medium	25	1	monocarboxylic acid; phosphonic acids	antiviral agent; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor
foscarnet	[no description available]	medium	29	0	carboxylic acid; one-carbon compound; phosphonic acids	antiviral drug; geroprotector; HIV-1 reverse transcriptase inhibitor; sodium-dependent Pi-transporter inhibitor
idoxuridine	[no description available]	medium	66	0	organoiodine compound; pyrimidine 2'-deoxyribonucleoside	antiviral drug; DNA synthesis inhibitor
idoxuridine	[no description available]	medium	66	1	organoiodine compound; pyrimidine 2'-deoxyribonucleoside	antiviral drug; DNA synthesis inhibitor
bromodeoxyuridine	[no description available]	medium	382	0	pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent
bromodeoxyuridine	[no description available]	medium	382	15	pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent
vidarabine	[no description available]	medium	38	0	beta-D-arabinoside; purine nucleoside	antineoplastic agent; bacterial metabolite; nucleoside antibiotic
vidarabine	[no description available]	medium	38	2	beta-D-arabinoside; purine nucleoside	antineoplastic agent; bacterial metabolite; nucleoside antibiotic
thymine arabinoside	[no description available]	medium	18	0	N-glycosyl compound
edoxudin	[no description available]	medium	10	0	pyrimidine 2'-deoxyribonucleoside
5-vinyl-2'-deoxyuridine	[no description available]	medium	4	0
5-ethynyl-2'-deoxyuridine	[no description available]	medium	5	0
bromodeoxycytidine	[no description available]	medium	5	0
carbocyclic 5-iodo-2'-deoxyuridine	[no description available]	medium	2	0
thymidine	[no description available]	medium	42	0	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
cytarabine	[no description available]	medium	22	0	beta-D-arabinoside; monosaccharide derivative; pyrimidine nucleoside	antimetabolite; antineoplastic agent; antiviral agent; immunosuppressive agent
deoxycytidine	[no description available]	medium	11	0	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
5-(2-bromovinyl)uridine	[no description available]	medium	3	0
amantadine	[no description available]	medium	17	0	adamantanes; primary aliphatic amine	analgesic; antiparkinson drug; antiviral drug; dopaminergic agent; NMDA receptor antagonist; non-narcotic analgesic
amantadine	[no description available]	medium	17	1	adamantanes; primary aliphatic amine	analgesic; antiparkinson drug; antiviral drug; dopaminergic agent; NMDA receptor antagonist; non-narcotic analgesic
1,5-anhydroglucitol	[no description available]	medium	1	0	anhydro sugar	human metabolite
5-(2-bromovinyl)uracil	[no description available]	medium	6	0
bromouracil	[no description available]	medium	8	0	nucleobase analogue; pyrimidines	mutagen
fluorodeoxyuridylate	[no description available]	medium	3	0	pyrimidine 2'-deoxyribonucleoside 5'-monophosphate

brivudine

Description

Cross-References

Synonyms (82)

Research Excerpts

Overview

Protein Targets (14)

Potency Measurements

Inhibition Measurements

Biological Processes (6)

Molecular Functions (5)

Ceullar Components (2)

Bioassays (1277)

Research

Studies (499)

Study Types

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