Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 5904 |
| CHEMBL ID | 29 |
| CHEBI ID | 18208 |
| SCHEMBL ID | 3783 |
| MeSH ID | M0016133 |
| Synonym |
|---|
| BRD-K55191674-236-03-7 |
| BRD-K55191674-237-02-7 |
| free penicillin ii |
| liquacillin |
| cilloral |
| penicillin, (phenylmethyl)- |
| cilopen |
| pradupen |
| nsc-193396 |
| cosmopen |
| free benzylpenicillin |
| benzylpenicillinic acid |
| penicillinic acid, (phenylmethyl)- |
| specilline g |
| gelacillin |
| pharmacillin |
| free penicillin g |
| dropcillin |
| benzylpenicillin g |
| CHEBI:18208 , |
| benzylpenicillinum |
| 2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylic acid |
| (2s,5r,6r)-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| bensylpenicillin |
| bencilpenicilina |
| 6-(2-phenylacetamido)penicillanic acid |
| benzyl benicillin |
| benzylpenicilline |
| DIVK1C_000316 |
| KBIO1_000316 |
| SPECTRUM_000933 |
| BSPBIO_001096 |
| SPECTRUM5_001108 |
| BSPBIO_002183 |
| PRESTWICK3_001078 |
| PRESTWICK2_001078 |
| phenylacetyl-6-aminopenicillanic acid |
| ursopen |
| 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- [2s-(2alpha,5alpha,6beta)]- |
| 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-, (2s,5r,6r)- |
| cillora |
| 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenylacetamido)- |
| (5r,6r)-benzylpenicillin |
| C05551 |
| 61-33-6 |
| benzylpenicillin |
| penicillin g |
| bicillin (*benzathine salt, tetrahydrate*) |
| penicillin-g potassium |
| benzyl penicillin |
| 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2s,5r,6r)- |
| (2s,5r,6r)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| DB01053 |
| NCGC00159348-02 |
| D02336 |
| benzylpenicillin (inn) |
| IDI1_000316 |
| benzylpenicillin [inn:ban] |
| (2s,5r,6r)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid |
| brn 0044740 |
| 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)-, (2s-(2alpha,5alpha,6beta))- |
| nsc 193396 |
| 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6- (2-phenylacetamido)- |
| pencillin g |
| benzylpenicillinum [latin] |
| hsdb 3166 |
| benzylpenicilline [french] |
| einecs 200-506-3 |
| 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)- (2s-(2alpha,5alpha,6beta))- |
| bencilpenicilina [spanish] |
| 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenylacetamido)- |
| KBIO3_001683 |
| KBIO2_001413 |
| KBIO2_006549 |
| KBIOSS_001413 |
| KBIOGR_000942 |
| KBIO2_003981 |
| SPBIO_002998 |
| SPECTRUM2_000518 |
| SPECTRUM4_000471 |
| PRESTWICK1_001078 |
| SPECTRUM3_000542 |
| PRESTWICK0_001078 |
| NINDS_000316 |
| SPBIO_000475 |
| BPBIO1_001206 |
| smr000538912 |
| MLS001173382 |
| PENICILLIN-G , |
| MLS000766897 |
| MLS001032123 |
| CHEMBL29 |
| j01ce01 |
| 3,3-dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid(penicillin g) |
| (2s,5r,6r)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid |
| 3,3-dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid anion (penicillin g) |
| bdbm50022787 |
| (+)-3,3-dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid(penicillin g) |
| (2s,5r,6r)-3,3-dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid |
| 3,3-dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid |
| (2s,5r,6r)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| A833169 |
| NCGC00159348-03 |
| HMS2875L09 |
| AKOS005203091 |
| unii-q42t66vg0c |
| q42t66vg0c , |
| 4-27-00-05861 (beilstein handbook reference) |
| phenoxymethylpenicillin (benzathine) tetrahydrate impurity a [ep impurity] |
| phenoxymethylpenicillin impurity a [ep impurity] |
| penicillin g [mi] |
| benzylpenicillin [inn] |
| benzylpenicillin [who-dd] |
| penicillin g [vandf] |
| penicillin g [hsdb] |
| phenoxymethylpenicillin potassium impurity a [ep impurity] |
| benzylpenicillin [mart.] |
| EPITOPE ID:114070 |
| gtpl4796 |
| SCHEMBL3783 |
| penicilling |
| JGSARLDLIJGVTE-MBNYWOFBSA-N |
| DTXSID5046934 , |
| W-109262 |
| benzylpenicillin, antibiotic for culture media use only |
| SBI-0051476.P003 |
| (2s,5r,6r)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| (2s,5r,6r)-3,3-dimethyl-7-oxo-6- |
| (2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0] |
| penicillin,(s) |
| Q258450 |
| BRD-K55191674-237-12-6 |
| (2s,5r,6r)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid |
| EN300-19631164 |
| 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2s,5r,6r)- |
| CS-0013727 |
| HY-N7139 |
| dtxcid3026934 |
| benzylpenicillinum (latin) |
| benzylpenicillin (mart.) |
| phenoxymethylpenicillin impurity a (ep impurity) |
| GLXC-25718 |
| benzylpenicillin 1000 microg/ml in acetonitrile:water |
Penicillin G is an unstable thioether that degrades in a range of pathways. It is one of the most predominant drug residues in animal-derived food products.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Penicillin G is an unstable thioether that degrades in a range of pathways." | ( Reactions of cisplatin and oxaliplatin with penicillin G: implications for drug inactivation and biological activity. Prokes, I; Sadler, PJ; Shi, H; Song, L; Wang, FX, 2022) | 1.7 |
| "Penicillin G is a widely used antimicrobial in food-producing animals, and one of the most predominant drug residues in animal-derived food products. " | ( Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment. Gehring, R; Li, M; Lin, Z; Riviere, JE, 2017) | 2.12 |
| "Penicillin G (PEN) is a widely used antibiotic whose mechanism of action is related to the interference with the synthesis of bacteria cell wall. " | ( Interaction of penicillin G with the human erythrocyte membrane and models. Aguilar, F; Sotomayor, CP; Suwalsky, M; Villena, F, ) | 1.93 |
Pencillin G has little effect on the SAD process. Penicillin G (PNG) has been demonstrated to elicit T-cell responsiveness in vitro in allergic patients by means of a lymphocyte transformation test (LTT)
| Excerpt | Reference | Relevance |
|---|---|---|
| "Penicillin G has little effect on the SAD process." | ( Simultaneous ANAMMOX and denitrification (SAD) process in batch tests. Jia, XS; Zhong, YM, 2013) | 1.11 |
| "Penicillin G (PenG) has successfully been used for therapy of dermal fibrosis in patients suffering from systemic sclerosis (SSc). " | ( Penicillin G does not alter collagen type I metabolism of dermal fibroblasts in culture. Anderegg, U; Haustein, UF; Wilczek, A, 2000) | 3.19 |
| "Penicillin G (PNG) has been demonstrated to elicit T-cell responsiveness in vitro in allergic patients by means of a lymphocyte transformation test (LTT). " | ( Penicillin-allergic patients react to penicillin-modified "self". Bell, SJ; Pichler, WJ, 1989) | 1.72 |
Pencillin G treatment slightly diminished the local tissue metabolic deterioration and significantly reduced the amount of debrided tissue as compared to untreated animals. In penicillin G-treated animals, the dermal lesions became smaller as early as day 3 of treatment and almost disappeared during the therapy.
Less toxic TunR1 and TunR2 both enhance the antibacterial activity of β-lactams: oxacillin by 32- to 64-fold. Extralabel use of penicillin G is common, which may lead to violative residues in edible tissues.
Mean values for elimination half-life and mean residence time of penicillin G were significantly higher in emus than in ostriches. No significant differences in antipyrine pharmacokinetics between species were demonstrated. Pharmacokinetic analysis determined that the disposition of peniillin G was best described by a two-compartment open model.
| Excerpt | Reference | Relevance |
|---|---|---|
| " The biological half-life of SBPC in the serum was shortened in pretreatment with GM and prolonged in posttreatment with GM, while that of GM did not vary in pre- or post-treatment with SBPC." | ( [Fundamental studies on combination of antibiotics; especially on pharmacokinetics. I. Combination of gentamicin with sulbenicillin or cephacetrile (author's transl)]. Aratani, H; Nakatsuka, M, 1976) | 0.26 |
| " In the case of sulbenicillin, the mean serum concentration at 1 hr was 157 plus or minus 25 mug/ml, the mean serum half-life was 70 plus or minus 10 min, the renal clearance was 95 plus or minus 25 ml/min, and the total urinary recovery after 24 hr was about 80% of the dose." | ( Pharmacokinetics of sulbenicillin, a new broad-spectrum semisynthetic penicillin. Hansen, IB; Jacobsen, E; Weis, J, 1975) | 0.25 |
| " Furthermore, pharmacokinetic analysis of the data obtained from in vivo and in vitro experiments indicated that PCG reduced the permeability of [14C]CDZM across the sinusoidal and bile canalicular membranes to 32% and 40% of the control value, respectively." | ( Effect of benzylpenicillin on the disposition of cefodizime in rats: no net effect on total clearance due to decreased hepatobiliary clearance and increased renal clearance. Hanano, M; Iga, T; Kawaguchi, Y; Matsushita, H; Sawada, Y; Sugiyama, Y; Suzuki, H, 1992) | 0.28 |
| "01) in Cmax and AUC occurred." | ( Effects of experimentally induced Streptococcus suis infection on the pharmacokinetics of penicillin G in pigs. Fung, KF; Zeng, ZL, 1990) | 0.5 |
| " There was a significant difference between the areas under the curve with change of posture but not between any of the other pharmacokinetic variables." | ( The effects of posture on the pharmacokinetics of intramuscular benzylpenicillin. Roberts, MS; Rumble, RH; Scott, AR, 1988) | 0.27 |
| "In order to assess pharmacokinetic differences between sulbenicillin (S) and piperacillin (P), two penicillin derivatives, 24 in-patients, 12 males and 12 females mean age 59." | ( Comparison between sulbenicillin and piperacillin levels in serum and in bronchial secretions--a pharmacokinetic study. Bichisao, E; Fraschini, F; Gaffuri Riva, V; Marchi, E; Scaglione, F; Scarpazza, G; Scarpazza, P, 1987) | 0.27 |
| " There were no significant differences between any of these pharmacokinetic variables with the change in posture." | ( The effect of posture on the pharmacokinetics of intravenous benzylpenicillin. Roberts, MS; Rumble, RH; Scott, AR, 1986) | 0.27 |
| " The mean penicillin plasma peak concentration and bioavailability were highest after the drug was injected in the neck and biceps musculature." | ( Effect of the injection site on the pharmacokinetics of procaine penicillin G in horses. Driessens, F; Firth, EC; Klein, WR; Nouws, JF; Peperkamp, K; Schmaetz, P, 1986) | 0.51 |
| "Sulbactam, a new beta-lactamase inhibitor, has pharmacokinetic characteristics in humans similar to those of ampicillin and amoxicillin." | ( Pharmacokinetics of sulbactam in humans. Foulds, G; Hayes, SL; Marshall, DC; McMahon, FG; O'Brien, MM; Stankewich, JP; Weidler, DJ, 1983) | 0.27 |
| " The half-life (t1/2 beta), however, did not change significantly over the 15-day period of the study." | ( Clearance of penicillin G in the newborn calf. Powers, JD; Powers, TE; Short, CR; Varma, KJ; White, MB, 1984) | 0.64 |
| " The aim of the present study was to establish the pharmacokinetic parameters of benzylpenicillin and cloxacillin administration in patients receiving high-dose benzylpenicillin or cloxacillin therapy by continuous infusion." | ( Clinical pharmacokinetics of continuous intravenous administration of penicillins. Arnouts, P; Mattie, H; van den Broek, PJ; van Furth, R; Visser, LG, 1993) | 0.29 |
| " Pharmacokinetic analysis determined that the disposition of penicillin G was best described by a two-compartment open model with penicillin concentrations in plasma (Cp) defined by two biexponential equations, Cp = 170." | ( Pharmacokinetics of penicillin G in plasma and interstitial fluid collected with dialysis fiber bundles in sheep. Bevill, RP; Cooke, IM; Koritz, GD; Nelson, DR, 1996) | 0.86 |
| "The pharmacodynamic effects of benzylpenicillin against Streptococcus pyogenes were studied in a new in vitro kinetic model in which bacterial outflow was prevented by a filter membrane." | ( Pharmacodynamic effects of sub-MICs of benzylpenicillin against Streptococcus pyogenes in a newly developed in vitro kinetic model. Bengtsson, S; Cars, O; Löwdin, E; Odenholt, I, 1996) | 0.29 |
| " Penicillin-G in serum was analysed by a microbiological method and pharmacokinetic parameters were calculated by model-independent methods." | ( Pharmacokinetics of penicillin-G in ewes and cows in late pregnancy and in early lactation. Bengtsson, B; Franklin, A; Jacobsson, SO; Luthman, J, 1997) | 0.3 |
| "The correlation between pharmacokinetic parameters and the in-vivo effect of antibiotics in relation to bacterial growth phases was evaluated using the mouse peritonitis model with a penicillin-resistant pneumococcus." | ( Pharmacodynamics of penicillin are unaffected by bacterial growth phases of Streptococcus pneumoniae in the mouse peritonitis model. Espersen, F; Frimodt-Møller, N; Knudsen, JD, 1998) | 0.3 |
| " The pharmaceutic and pharmacokinetic relevance of the chemical and physical factors as well as the influence of the particle size of the active principle were demonstrated with benzylpenicillin potassium in the in vitro model of the isolated perfused bovine udder." | ( [Pharmacokinetic aspects of mastitis therapy]. Ehinger, AM; Kietzmann, M, 1998) | 0.3 |
| " Mean values for elimination half-life and mean residence time of penicillin G were significantly higher in emus than in ostriches; no significant differences in antipyrine pharmacokinetics between species were demonstrated." | ( Intravenous pharmacokinetics of penicillin G and antipyrine in ostriches (Struthio camelus) and emus (Dromaius novaehollandiae). Clarke, CR; Cudd, LA; Kocan, AA; Wang, Z; Webb, AI, 2001) | 0.83 |
| "7%) and a prolongation of the elimination half-life of penicillin (17." | ( Effect of Tomanol on the pharmacokinetics and tissue distribution of penicillin G in dairy cows. Hekman, P; Nouws, JF; van Ginneken, CA, 1982) | 0.5 |
| " The aim of the present study was to develop a semimechanistic pharmacokinetic (PK)/pharmacodynamic (PD) model characterizing the events seen in a bacterial system when it is exposed to antibacterial agents with different mechanisms of action." | ( Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments. Cars, O; Karlsson, MO; Löwdin, E; Nielsen, EI; Sandström, M; Viberg, A, 2007) | 0.34 |
| " The pharmacokinetics of penicillin G were best described by a two-compartment pharmacokinetic model." | ( Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks. Bult, Y; Danhof, M; DeJongh, J; Goessens, WH; Mouton, JW; Muller, AE; van den Anker, JN, 2007) | 0.97 |
| " pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic data." | ( Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Lombardo, F; Obach, RS; Waters, NJ, 2008) | 0.35 |
| " The sigmoid maximum-threshold-of-efficacy (E(max)) model fit the survival data, in which the free-drug area under the concentration-time curve (fAUC)/MIC ratio, the maximum concentration of free drug in plasma (fC(max))/MIC ratio, and the cumulative percentage of a 24-h period that the free-drug concentration exceeds the MIC under steady-state pharmacokinetic conditions (f %T(MIC)) were each evaluated." | ( Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. Ambrose, PG; Bassett, J; Beaudry, A; Bhavnani, SM; Critchley, I; Gill, SC; Heine, HS; Janjic, N; Li, J; Miller, L; Rubino, CM; Stone, KC, 2010) | 0.36 |
| "We performed a post-hoc analysis of a pharmacokinetic (PK) study of penicillin-G, enrolling 18 neonates with a birth weight of <1,200 g, gestational age of <28 weeks and postnatal age of <5 days, with a risk of early onset sepsis." | ( Blood loss related to participation in pharmacokinetic study in preterm neonates. Heidmets, LT; Ilmoja, ML; Lutsar, I; Metsvaht, T; Oselin, K; Pisarev, H, 2011) | 0.37 |
| " Pharmacokinetic parameters were comparable to those reported for eutherians of equivalent size and suggest that the practice of adjusting allometrically scaled doses to account for the lower metabolic rate of marsupials may not be valid." | ( Single-dose pharmacokinetics of oxytetracycline and penicillin G in tammar wallabies (Macropus eugenii). Barker, IK; Crawshaw, G; Hinds, LA; Johnson, R; McLelland, DJ; Spilsbury, L, 2011) | 0.62 |
| " There are, however, no population pharmacokinetic studies of penicillin G for food animals." | ( Interspecies mixed-effect pharmacokinetic modeling of penicillin G in cattle and swine. Baynes, R; Gehring, R; Huang, Q; Li, M; Riviere, JE; Tell, L, 2014) | 0.89 |
| " Pharmacodynamic models describing the relationship between the concentration of antimicrobials and the minimum growth rate of the bacteria provide more detailed information than the MIC only." | ( Time-kill curve analysis and pharmacodynamic modelling for in vitro evaluation of antimicrobials against Neisseria gonorrhoeae. Althaus, CL; Foerster, S; Hathaway, LJ; Low, N; Unemo, M, 2016) | 0.43 |
| " The experimental time-kill curves were analysed and quantified with a previously established pharmacodynamic model." | ( Time-kill curve analysis and pharmacodynamic modelling for in vitro evaluation of antimicrobials against Neisseria gonorrhoeae. Althaus, CL; Foerster, S; Hathaway, LJ; Low, N; Unemo, M, 2016) | 0.43 |
| " gonorrhoeae time-kill curve experiments analysed with a pharmacodynamic model have potential for in vitro evaluation of new and existing antimicrobials." | ( Time-kill curve analysis and pharmacodynamic modelling for in vitro evaluation of antimicrobials against Neisseria gonorrhoeae. Althaus, CL; Foerster, S; Hathaway, LJ; Low, N; Unemo, M, 2016) | 0.43 |
| "Organic anion transporters (OATs) are important in the renal secretion, and thus, the clearance, of many drugs; and their functional change can result in pharmacokinetic variability." | ( Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach. Feng, B; Litchfield, J; Mathialagan, S; Piotrowski, MA; Tess, DA; Varma, MV, 2017) | 0.46 |
| " This study aimed to develop a physiologically based pharmacokinetic (PBPK) model to predict drug residues in edible tissues and estimate extended withdrawal intervals for penicillin G in swine and cattle." | ( Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment. Gehring, R; Li, M; Lin, Z; Riviere, JE, 2017) | 0.87 |
| " Modern pediatric pharmacokinetic study protocols frequently favor opportunistic, "scavenged" sampling." | ( Development of a Novel Multipenicillin Assay and Assessment of the Impact of Analyte Degradation: Lessons for Scavenged Sampling in Antimicrobial Pharmacokinetic Study Design. Barker, CIS; Johnston, A; Kipper, K; Sharland, M; Standing, JF, 2018) | 0.48 |
| " Pharmacokinetic data for non-ICU hospitalized populations are lacking." | ( Pharmacokinetics and Pharmacodynamic Target Attainment of Benzylpenicillin in an Adult Severely Ill Sub-Saharan African Patient Population. Beirão, JC; Bos, JC; Lang, CN; Mathôt, RAA; Mistício, MC; Nunguiane, G; Prins, JM; van Hest, RM, 2018) | 0.48 |
| "We performed a population pharmacokinetic (PPK) study in an adult Mozambican hospital population treated intravenously with PEN from October 2014 through November 2015." | ( Pharmacokinetics and Pharmacodynamic Target Attainment of Benzylpenicillin in an Adult Severely Ill Sub-Saharan African Patient Population. Beirão, JC; Bos, JC; Lang, CN; Mathôt, RAA; Mistício, MC; Nunguiane, G; Prins, JM; van Hest, RM, 2018) | 0.48 |
| " Physiologically based pharmacokinetic (PBPK) models are useful tools to predict withdrawal intervals and tissue residues of drugs in food animals to ensure food safety, especially for extralabel drug use due to the scarcity of experimental data after extralabel administrations." | ( Probabilistic Physiologically Based Pharmacokinetic Model for Penicillin G in Milk From Dairy Cows Following Intramammary or Intramuscular Administrations. Gehring, R; Li, M; Lin, Z; Riviere, JE, 2018) | 0.72 |
| " The collected new data and other available data from the literature were used to develop a population physiologically based pharmacokinetic (PBPK) model for penicillin G in heavy sows." | ( An integrated experimental and physiologically based pharmacokinetic modeling study of penicillin G in heavy sows. Coetzee, JF; Gehring, R; Karriker, LA; Li, M; Lin, Z; Mainquist-Whigham, C; Riviere, JE; Wulf, LW; Zeng, D, 2019) | 0.93 |
| " Great efforts have been made to develop physiologically based pharmacokinetic (PBPK) models for estimating withdrawal intervals (WDIs) for extralabel prescribed drugs in food animals." | ( An Interactive Generic Physiologically Based Pharmacokinetic (igPBPK) Modeling Platform to Predict Drug Withdrawal Intervals in Cattle and Swine: A Case Study on Flunixin, Florfenicol, and Penicillin G. Baynes, RE; Chou, WC; Davis, JL; Lin, Z; Maunsell, FP; Riviere, JE; Tell, LA, 2022) | 0.91 |
When administered with penicillin G, tobramycin given once daily was as efficacious and safe as tobramYcin given three times daily in patients with febrile neutropenia.
| Excerpt | Reference | Relevance |
|---|---|---|
| "An experimental dog model was used to reproduce the clinical picture of bilateral arteriole and choriocapillaris occlusion from a unilateral intracarotid injection of long-acting corticosteroids combined with other drugs including lidocaine, epinephrine, and penicillin." | ( Bilateral retinal artery and choriocapillaris occlusion following the injection of long-acting corticosteroid suspensions in combination with other drugs: II. Animal experimental studies. McGrew, RN; White, HJ; Wilson, RS, 1978) | 0.26 |
| "The dynamics of penicillin concentrations in the blood and lung tissue of animals with chronic experimental pneumonia after its repeated administration in combination with prednisolone was studied." | ( [Penicillin distribution in the body of animals with experimental chronic pneumonia when administered repeatedly in combination with prednisolone]. Sazonov, VF, 1976) | 0.26 |
| "Fifteen strains of Enterococcus faecalis, all clinical blood culture isolates from patients with endocarditis, were studied by kill-kinetic experiments using penicillin G, ampicillin and amoxicillin alone and in combination with tobramycin." | ( Bactericidal effect of penicillin, ampicillin, and amoxicillin alone and in combination with tobramycin against Enterococcus faecalis as determined by kill-kinetic studies. Frimodt-Møller, N; Gutschik, E; Westh, H, ) | 0.33 |
| "In this study penicillin alone versus penicillin combined with anti-anthrax serum were compared in the treatment of experimental anthrax of mice." | ( [Evaluation of penicillin alone and penicillin combined with anti-anthrax serum in experimental anthrax in mice]. Doğanay, M; Hanağasi, R; Zora, A, 1985) | 0.27 |
| "If a bactericidal drug is combined with an agent which is only bacteristatic, the killing effect may be antagonized, since many bactericidal drugs only kill rapidly multiplying cells." | ( Drug combinations in antibacterial chemotherapy. Barber, M, 1965) | 0.24 |
| "The in vitro bactericidal interactions of penicillin G, cefotaxime, or vancomycin in combination with gentamicin were compared against 20 group G streptococci by the timed kill curve method." | ( In vitro bactericidal synergy of gentamicin combined with penicillin G, vancomycin, or cefotaxime against group G streptococci. Bayer, AS; Lam, K, 1984) | 0.78 |
| "The activities of moxalactam and cefotaxime, alone and combined with ampicillin or penicillin, against 40 isolates of group B streptococci were assessed by using the microtiter broth dilution, checkerboard, and time-kill techniques." | ( Activity of moxalactam and cefotaxime alone and in combination with ampicillin or penicillin against group B streptococci. Cherubin, CE; Corrado, ML; Landesman, SH; Sierra, MF, 1981) | 0.26 |
| " This study demonstrated the efficacy of penicillin and clavulanic acid in the treatment of infections caused by Bacteroides fragilis alone or in combination with beta-lactamase-producing aerobic bacteria." | ( Antibiotic and clavulanic acid treatment of subcutaneous abscesses caused by Bacteroides fragilis alone or in combination with aerobic bacteria. Brook, I; Coolbaugh, JC; Walker, RI, 1983) | 0.27 |
| "Since the optimal antimicrobial therapy for infections caused by Listeria monocytogenes, particularly in patients allergic to penicillin, is uncertain, we investigated the in vitro effects of erythromycin, alone and in combination with other antibiotics, on listeriae." | ( Effects of erythromycin in combination with penicillin, ampicillin, or gentamicin on the growth of Listeria monocytogenes. Penn, RL; Steigbigel, RT; Ward, TT, 1982) | 0.26 |
| " The clinical picture was markedly mitigated by the early initiation of silybin therapy, in combination with penicillin and cortisone." | ( [Treatment of Amanita phalloides poisoning with silybin in combination with penicillin and cortisone]. Egermann, G; Hofer, JF; Mach, K; Sommer, K, 1983) | 0.27 |
| "For the individual determination of residual drug concentrations in meat when using penicillin-G (PC-G) in combination with one of the aminoglycoside antibiotics, the differentiation of PC-G and the aminoglycoside groups was easily accomplished by incubation of the individual drug with penicillinase (PCase)." | ( Simple bacteriological and thin-layer chromatographic methods for determination of individual drug concentrations treated with penicillin-G in combination with one of the aminoglycosides. Kondo, F; Lin, SY, 1994) | 0.29 |
| "We examined the efficacy of gentamicin combined with beta-lactam antibiotics against penicillin-resistant Streptococcus pneumoniae (PRSP) in a noncompromised mouse model of pneumonia." | ( Efficacy of beta-lactam antibiotics combined with gentamicin against penicillin-resistant pneumococcal pneumonia in CBA/J mice. Matsumoto, T; Miyazaki, S; Tateda, K; Yamaguchi, K, 1999) | 0.3 |
| "The objective of the present study was to evaluate the therapeutic potential of bovine lactoferrin or lactoferricin in combination with penicillin G against Staphylococcus aureus." | ( Effect of lactoferrin in combination with penicillin on the morphology and the physiology of Staphylococcus aureus isolated from bovine mastitis. Diarra, MS; Lacasse, P; Petitclerc, D, 2002) | 0.52 |
| "Convulsant activity of pazufloxacin mesilate (PZFX mesilate), a new quinolone antibacterial agent for intravenous use, in combination with nonsteroidal anti-inflammatory drug (NSAID) was investigated in mice after intravenous or intracerebroventricular administration." | ( [Drug interactions between nonsteroidal anti-inflammatory drug and pazufloxacin mesilate, a new quinolone antibacterial agent for intravenous use: convulsions in mice after intravenous or intracerebroventricular administration]. Fukuda, H; Kawamura, Y, 2002) | 0.31 |
| " In this study, we have investigated the effects of bovine lactoferrin alone or in combination with penicillin G on the phagocytic activity of bovine polymorphonuclear leukocytes against Staphylococcus aureus." | ( Lactoferrin against Staphylococcus aureus Mastitis. Lactoferrin alone or in combination with penicillin G on bovine polymorphonuclear function and mammary epithelial cells colonisation by Staphylococcus aureus. Deschênes, E; Diarra, MS; Grondin, G; Lacasse, P; Lessard, N; Petitclerc, D; Talbot, BG, 2003) | 0.75 |
| " After the short-term treatment of low dose of corticosteroid combined with continuous antibiotics, high fever and renal insufficiency were dramatically improved." | ( Successful recovery of infective endocarditis-induced rapidly progressive glomerulonephritis by steroid therapy combined with antibiotics: a case report. Haneda, M; Kikkawa, R; Koya, D; Shibuya, K, 2004) | 0.32 |
| " Although the participation of the particular transporters in observed drug-drug interactions can be difficult to confirm in humans, this review focuses mainly on pharmacokinetic interactions of clinically important drugs." | ( Transporter-mediated Drug Interactions. Tsuji, A, 2002) | 0.31 |
| "When administered with penicillin G, tobramycin given once daily was as efficacious and safe as tobramycin given three times daily in cancer patients with febrile neutropenia in Norway, provided the regimen was modified according to the clinical response." | ( Tobramycin once versus three times daily, given with penicillin G, to febrile neutropenic cancer patients in Norway: a prospective, randomized, multicentre trial. Bø, K; Grøttum, K; Holte, H; Høiby, EA; Jacobsen, AB; Kvaløy, S; Lauritzsen, GF; Meyer, P; Olsen, H; Sandstad, B; Tangen, JM; Torfoss, D; Weyde, K, 2007) | 0.9 |
| "The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug-drug interactions." | ( Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR, 2012) | 0.38 |
| " Synergism was reported and therapeutic efficacy was significantly enhanced when DM3 was formulated in combination with penicillin (PEN)." | ( In vivo efficacy and molecular docking of designed peptide that exhibits potent antipneumococcal activity and synergises in combination with penicillin. Hassan, MA; Isa, DM; Le, CF; Lee, VS; Sekaran, SD; Yusof, MY, 2015) | 0.42 |
| " This mechanistic static approach was further applied to quantitatively predict renal drug-drug interactions (AFE ∼1." | ( Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach. Feng, B; Litchfield, J; Mathialagan, S; Piotrowski, MA; Tess, DA; Varma, MV, 2017) | 0.46 |
| " Continuous-infusion benzylpenicillin via a 24 h elastomeric infusor, combined with either once-daily gentamicin or ceftriaxone, requires only one nursing encounter daily and is commonly used in New Zealand." | ( Outpatient continuous-infusion benzylpenicillin combined with either gentamicin or ceftriaxone for enterococcal endocarditis. Bhally, H; Briggs, S; Broom, M; Duffy, E; Everts, G; Everts, R; Lowe, B; McBride, S, 2021) | 0.62 |
| "A retrospective observational case series from multiple hospitals of patients aged 15 years or over with enterococcal endocarditis diagnosed between July 2013 and June 2019 who received at least 14 days of outpatient continuous-infusion benzylpenicillin combined with either gentamicin or ceftriaxone for synergy." | ( Outpatient continuous-infusion benzylpenicillin combined with either gentamicin or ceftriaxone for enterococcal endocarditis. Bhally, H; Briggs, S; Broom, M; Duffy, E; Everts, G; Everts, R; Lowe, B; McBride, S, 2021) | 0.62 |
| "Outpatient treatment of enterococcal endocarditis with continuous-infusion benzylpenicillin combined with either once-daily gentamicin or ceftriaxone following a period of inpatient treatment is usually effective." | ( Outpatient continuous-infusion benzylpenicillin combined with either gentamicin or ceftriaxone for enterococcal endocarditis. Bhally, H; Briggs, S; Broom, M; Duffy, E; Everts, G; Everts, R; Lowe, B; McBride, S, 2021) | 0.62 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Intestinal absorption rate constants of amoxicillin, ampicillin, epicillin, cyclacillin and azidocillin, by means of a static in situ intestinal perfusion method has been estimated." | ( Intestinal absorption kinetics of a series of aminopenicillins and azidocillin. A comparative study in the rat. Margarit, F; Moreno-Dalmau, J; Obach, R; Peraire, C; Plá-Delfina, JM, 1991) | 0.28 |
| " The mean penicillin plasma peak concentration and bioavailability were highest after the drug was injected in the neck and biceps musculature." | ( Effect of the injection site on the pharmacokinetics of procaine penicillin G in horses. Driessens, F; Firth, EC; Klein, WR; Nouws, JF; Peperkamp, K; Schmaetz, P, 1986) | 0.51 |
| "In a comparative kinetic study of the serum concentrations of two penicillin complexes--medium-long-acting (benethamine penicillin) and long-acting (benzathine bipenicillin)--after a single injection in young adults and elderly people, the following results were confirmed statistically: (a) age was a major factor in the variations in serum penicillin concentrations and in their persistence in the serum; (b) the penicillin was absorbed faster in young than in elderly subjects even when a long-acting complex was used; (c) serum concentrations below the level regarded as lethal for treponemes appeared much earlier and more frequently in young than in old people; and (d) the bioequivalence between penicillin preparations could not be estimated solely for the number of units of the agent used but from the bioavailability of the chosen formulation." | ( Kinetic study of serum penicillin concentrations after single doses of benzathine and benethamine penicillins in young and old people. Collart, P; Durel, J; Herlin, A; Milovanovic, A; Poitevin, M, 1980) | 0.26 |
| " The absorption rate for benzylpenicillin from the mammary gland was reduced by probenecid, as measured by the ratio of benzylpenicillin to urea absorption half-life, which was increased by 40-50% in the presence of probenecid." | ( Active transport of benzylpenicillin across the blood-milk barrier. Frey, HH; Merck, CC; Nielsen, P; Rasmussen, F; Schadewinkel-Scherkl, AM, 1993) | 0.29 |
| " The rate of absorption (t1/2ab and Tmax) was slower after subcutaneous compared to intramuscular injection, but the extent of absorption (AUC) was similar for both routes of administration." | ( Influence of injection site on the absorption of benzylpenicillin sodium in the dromedary. Oukessou, M, 1995) | 0.29 |
| " The success of systemic treatment is influenced by the bioavailability of the chemotherapeutic agent." | ( [Pharmacokinetic aspects of mastitis therapy]. Ehinger, AM; Kietzmann, M, 1998) | 0.3 |
| "Many beta lactams are well absorbed by the small intestine, although the reasons for this are poorly understood." | ( Characterisation of penicillin G uptake in human small intestinal brush border membrane vesicles. Fairclough, PD; Hammond, SM; Poschet, JF, 1999) | 0.63 |
| " Bioavailability was 10." | ( Bioavailability and disposition of sodium and procaine penicillin G (benzylpenicillin) administered orally with milk to calves. Anderson, KL; Musser, JM, 2001) | 0.56 |
| "The utilization of the membrane transport protein PEPT1 as a drug delivery system is a promising strategy to enhance the oral bioavailability of drugs." | ( Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. Biegel, A; Brandsch, M; Gebauer, S; Hartrodt, B; Neubert, K; Thondorf, I, 2005) | 0.33 |
| " Human oral bioavailability is an important pharmacokinetic property, which is directly related to the amount of drug available in the systemic circulation to exert pharmacological and therapeutic effects." | ( Hologram QSAR model for the prediction of human oral bioavailability. Andricopulo, AD; Moda, TL; Montanari, CA, 2007) | 0.34 |
| " The poor intracellular bioavailability of antibiotics reduces the efficency of many treatments and thereby promotes resistances." | ( An efficient system for intracellular delivery of beta-lactam antibiotics to overcome bacterial resistance. Abed, N; Couvreur, P; Desmaële, D; Gref, R; Mougin, J; Nicolas, V; Saïd-Hassane, F; Zouhiri, F, 2015) | 0.42 |
The daily dosage of penicillin G ranged from 110,000 to 165,000 U/kg. The dosage of ampicillin varied from 77 to 110 mg/kg (35-50 mg/lb) Addition of peniillin G-resistant microorganisms together with the antibiotic dosage into the wild culture prevented death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Rosaramicin at 100 mg/kg per day intramuscularly for 5 days cured only 5 of 15 rabbits with meningitis, but a higher dosage regimen of that drug (250 mg/kg per day intramuscularly) produced acute, fulminant enterocecitis and death within 48 h in seven of eight rabbits." | ( Rosaramicin versus penicillin G in experimental Pneumococcal meningitis. Monson, TP; Nolan, CM; Ulmer, WC, 1979) | 0.59 |
| " Failure to suppress allergic manifestations was reported in 11 cases, among which some may have been due to insufficient dosage of inhibiting hapten." | ( Clinical trial of Ro 6-0787, a monovalent specific hapten inhibitor of penicillin allergy. De Weck, AL; Girard, JP; Grilliat, JP; Jeunet, F; Juhlin, L; Louis, P; Moneret-Vautrin, D; Scheiffarth, F; Schulz, KH; Spengler, H; Storck, H; Virgaay, SR; Warnatz, H; Wortmann, F; Wuthrich, B, 1975) | 0.25 |
| " The penicillin type shows almost no improvement in bactericidal activity despite increasing the dosage above a certain level." | ( [Bactericidal dosie-activity relationships with E. coli, K. pneumoniae and Staph. aureus (author's transl)]. Shah, PM; Stille, W, 1976) | 0.26 |
| " In a comprehensive series of experiments, various dosage schedules were explored." | ( Cytochrome C as antidote in mice poisoned with the mushroom toxin alpha-amanitin. Floersheim, GL, 1977) | 0.26 |
| " Bacterial lysis by penicillin was concentration-dependent and showed an optimal dosage effect which was very marked for one of the strains." | ( The response of Staphylococcus aureus to benzylpenicillin. Elliott, TS; Greenwood, D; O'Grady, F; Rodgers, FG, 1979) | 0.26 |
| " The daily dosage of penicillin G ranged from 110,000 to 165,000 U/kg (50,000-75,000 U/lb), and the dosage of ampicillin varied from 77 to 110 mg/kg (35-50 mg/lb)." | ( Penicillin G or ampicillin for oral treatment of canine urinary tract infections. Gilmore, CJ; Ling, GV, 1977) | 2.02 |
| " It is pointed out, that in a modern treatment there must be given Penicillin-G-Natrium in high dosage as early as possible, also in cases of questionableness." | ( [Mushroom poisoning in childhood]. Gudowski, G; Koloc, C; Rechlin, R, 1979) | 0.26 |
| "Five patients suffering from dementia paralytica who failed to improve or deteriorated after one or several high dosage courses of penicillin, had pneumoencephalographic patterns suggesting communicating hydrocephalus." | ( Dementia paralytica: deterioration from communicating hydrocephalus. Benito, C; Giménez-Roldán, S; Martin, M, 1979) | 0.26 |
| " The present observations and those of other authors working in this area are discussed and an approach to drug dosage of renally excreted drugs in kwashiorkor has been proposed." | ( Penicillin pharmacokinetics in kwashiorkor. Buchanan, N; Eyberg, C; Koornhof, HJ; Robinson, R, 1979) | 0.26 |
| "A novel computerized automated system is described which conforms to the basic requirements set forth in the compendia for testing the dissolution characteristics of solid dosage forms." | ( ADS-12: an automated programmable 12-tablet dissolution testing system. Bendrot, H; Cioffi, FJ; Martynovych, S, 1979) | 0.26 |
| " Daily dosage of SBPC was 10g in two divided doses in most cases given by the intravenous infusion." | ( [Chemotherapy of peritonitis with particular reference to concentrations of sulbenicillin in human ascites (author's transl)]. Fujii, K; Hikasa, Y; Honda, K; Izukura, T; Jujo, H; Kobayashi, N; Maruyama, K; Nishijima, Y; Nomoto, S; Okabayashi, H; Sekiya, T; Setoyama, M; Tanimura, H; Yasumoto, H, 1978) | 0.26 |
| " Penicillin was given at a daily intramuscular dosage of 40,000 units procaine penicillin G beginning 2 days prior to exposure and continuing through the third day after exposure." | ( Protective effect of prophylactic penicillin on splenectomized mice exposed to an aerosolized suspension of type III Streptococcus pneumoniae. Bolton, E; Chalmer, BJ; Coil, JA; Dickerman, JD; Jakab, GJ, 1979) | 0.49 |
| "The alterations of early syphilitic infection occuring in the course of high dosage penicillin (120 mega IU, 36 h) as clinical experimental trial has been studied both from the clinical and the electron microscopical views." | ( Treponema pallidum in early syphilitic lesions in humans during high-dosage penicillin therapy. An electron microscopical study. Bartunek, J; Stüttgen, G; Wecke, J, 1976) | 0.26 |
| "Data on 40 patients with Staphylococcus aureus endocarditis treated with appropriate antibiotics in adequate dosage at the University of Cincinnati Medical Center hospitals between January 1961 and June 1975 were analyzed." | ( Prognostic factors in Staphylococcus aureus endocarditis and results of therapy with a penicillin and gentamicin. Baird, IM; Watanakunakorn, C, ) | 0.13 |
| " Penicillin G in the dosage studied is adequate therapy for most streptococcal and meningococcal meningitis in children; an increased dosage may be necessary when the minimal inhibitory concentration of penicillin to the etiologic agent is unusually high." | ( A pharmacologic evaluation of penicillin in children with purulent meningitis. Hieber, JP; Nelson, JD, 1977) | 1.17 |
| "Prophylactic (preventive) antibiotic therapy initiated preoperatively, with antibiotics administered in moderately high dosage for short periods, is recommended on the basis of experimental and prospective, randomized clinical trials for patients who require surgery that is likely to expose tissue planes to contamination." | ( Prophylactic antibiotic therapy in surgery. MacLean, LD, 1975) | 0.25 |
| " Both these antimicrobials seem appropriate for the treatment of meningitis caused by penicillin G-resistant pneumococci provided their dosage is adjusted to achieve adequate drug levels in the cerebrospinal fluid." | ( [Bacteriostatic activity and killing curves of eight antibiotics against seven strains of penicillin G-resistant pneumococci]. Barakett, V; Burghoffer, B; Delisle, F; Guidet, B; Lesage, D; Offenstadt, G; Petit, JC; Richard, G; Vergez, P, 1992) | 0.73 |
| "The aqueous suspensions for intramuscular administration belong to the group of the dosage forms, that have a sustained release behaviour." | ( In vitro evaluation of the dissolution rate of crystalline suspensions destined to intramuscular administration. Burgos, ML; Cadorniga, R; Molina, IT; Negro, S; Nernanez, MT; Pastoriza, P, 1991) | 0.28 |
| " The study presented here was designed to compare cefotaxime at a dosage of 2 x 3 g/day with penicillin G at a dosage of 2 x 10 megaunits/day, for ten days in a prospective randomized trial." | ( Cefotaxime versus penicillin in the late stage of Lyme disease--prospective, randomized therapeutic study. Hassler, D; Haude, M; Heinrich, F; Hufnagel, HD; Sonntag, HG; Zöller, L, ) | 0.35 |
| " It was concluded that benzylpenicillin elimination occurs more slowly in the dromedary than in sheep and that use of the same dosage regimen for the two ruminant species may lead to significant differences in plasma concentrations and therapeutic efficacy." | ( Comparative benzylpenicillin pharmacokinetics in the dromedary Camelus dromedarius and in sheep. Hossaini, J; Oukessou, M; Toutain, PL; Zine-Filali, R, 1990) | 0.28 |
| " These modifications in benzylpenicillin kinetics were explained in terms of fluid balance adjustments and renal function adaptation observed during pregnancy and lactation, and it is suggested that an appropriate dosage regimen for benzylpenicillin should take into account the physiological status of the animal." | ( Benzylpenicillin kinetics in the ewe: influence of pregnancy and lactation. Benlamlih, S; Oukessou, M; Toutain, PL, 1990) | 0.28 |
| " If a PAE is present in vivo, antibiotic levels in tissue at the site of infection may decrease below the MIC without bacterial regrowth in the latter portion of the dosing interval." | ( Postantibiotic effect of penicillin plus gentamicin versus Enterococcus faecalis in vitro and in vivo. Hessen, MT; Levison, ME; Pitsakis, PG, 1989) | 0.28 |
| " Addition of penicillin G-resistant microorganisms together with the antibiotic dosage into the wild culture prevented death." | ( Growth kinetics of Streptococcus thermophilus at subbacteriostatic penicillin G concentrations. Bozoglu, TF; Ozilgen, M; Yöndem, F, 1989) | 0.88 |
| " Each antimicrobial agent was diluted with sterile water for injection to a concentration representative of the most common dosage when administered via a portable infusion pump." | ( Stability of cefazolin sodium, cefoxitin sodium, ceftazidime, and penicillin G sodium in portable pump reservoirs. Allen, LV; Stiles, ML; Tu, YH, 1989) | 0.51 |
| " The effects of subinhibitory concentrations on streptococci previously exposed to penicillin may therefore be a more important factor in determining dosage intervals than the PAE." | ( Effects of benzylpenicillin on Streptococcus pyogenes during the postantibiotic phase in vitro. Cars, O; Holm, SE; Odenholt, I, 1989) | 0.28 |
| " In contrast, clindamycin was highly effective over a broad dosing range (8." | ( Comparison of clindamycin, rifampin, tetracycline, metronidazole, and penicillin for efficacy in prevention of experimental gas gangrene due to Clostridium perfringens. Laine, BM; Maier, KA; Mitten, JE; Stevens, DL, 1987) | 0.27 |
| " There was a striking association between tolerance and Eagle's optimum dosage effect, particularly among strains that displayed tolerance in both the stationary and the logarithmic growth phases." | ( Tolerance to penicillin in streptococci of viridans group. Greenwood, D; Meeson, J; Powley, L, 1989) | 0.28 |
| " Antibiotic therapy initially at a high dosage followed by prolonged oral therapy is generally recommended." | ( Ureteric obstruction secondary to pelvic actinomycosis. Jackson, AE; Parry, JR; Shah, PJ, 1988) | 0.27 |
| "2 million U intramuscularly daily for 20 days is as effective as a dosage schedule which requires admission to hospital for intravenous administration." | ( Treatment of neurosyphilis. A comparison of penicillin regimens. Callanan, JJ; Forder, AA; Philcox, DV, 1987) | 0.27 |
| " Conformity to Beer's law enabled the assay of dosage forms of these drugs." | ( Utility of chloranil in assay of naphazoline, clemizole, penicillin G sodium, and piperazine. Abdel-Hamid, ME; Abdine, H; Belal, S; Elsayed, MA, 1981) | 0.51 |
| "We introduce a kinetic method for determining whether the descending limb of a biphasic histamine release dose-response curve is the result of insufficient cross-linking, and delineate conditions under which it is applicable." | ( A method for determining whether the descending limb of a biphasic histamine release curve reflects insufficient cross-linking. Delisi, C; Perelson, AS; Siraganian, RP, 1982) | 0.26 |
| " A significant relationship was observed between tolerance and Eagle's optimum dosage effect: 71% of tolerant strains examined displayed the Eagle effect, whereas only 17% of non-tolerant strains exhibited the effect." | ( Detection of penicillin tolerance in streptococci. Greenwood, D; Slater, GJ, 1983) | 0.27 |
| "This review considers the five major principles governing optimal dosing of beta-lactam antibiotics in therapy for bacterial meningitis: off the entry of passage of antibiotics into CSF, (2) the antimicrobial activity of beta-lactams within the purulent CSF in vivo, (3) the bactericidal activity within the CSF, (4) the route and mode of drug administration together with the postantibiotic effect, and (5) the duration of therapy." | ( Rationale for optimal dosing of beta-lactam antibiotics in therapy for bacterial meningitis. Scheld, WM, 1984) | 0.27 |
| "Twenty-one adult horses were randomly assigned into 7 groups of 3 and were treated for 5 days with procaine penicillin G, benzathine penicillin , or phenylbutazone in various combinations and dosage schedules." | ( Serum concentration of penicillin in the horse after repeated intramuscular injections of procaine penicillin G alone or in combination with benzathine penicillin and/or phenylbutazone. Messer, NT; Nelson, L; Sullins, KE, 1984) | 0.7 |
| "3%; when the dosage was increased to 600,000 U/day, the mortality ws 37." | ( Is penicillin alone effective in enterococcal endocarditis? An experimental study in rabbits. Bach, VT; Mandal, AK; Rambhatla, K; Thadepalli, H, 1981) | 0.26 |
| " As a result of the experiments the following dosage regimes could be recommended for each drug." | ( Serum concentrations of penicillin in the horse after administration of a variety of penicillin preparations. Bailey, M; Love, DN; Martin, IC; Rose, RJ, 1983) | 0.27 |
| " dosage were 57-60% for the tablets and 64% for the suspension." | ( Pharmacokinetics of azidocillin in healthy adults. Bergan, T; Sørensen, G, 1980) | 0.26 |
| " Of the 493 women in the study, 254 received dosed of 2 million IU of penicillin G intermuscularly 1/2 hour before and 3 hours after the procedure, followed by 350 mg of pivampicillin 3 times daily for 4 days, and 239 women received corresponding doses of placebo." | ( Prophylactic antibiotics in first-trimester abortions: a clinical, controlled trial. Andersen, JT; Dyring-Andersen, K; Hebjøorn, S; Heisterberg, L; Hejl, BL; Sonne-Holm, S, 1981) | 0.5 |
| " Combination of spore treatment with antibiotic chemotherapy in dosage able to prevent oncolysis or in dosage to reduce them corresponds with loss of clostridial multiplication or with reduced vegetative multiplication respectively." | ( Measurement of specific multiplication of an oncolytic and a nononcolytic strain of Clostridium butyricum inside the tumour UVT 15264 of the mouse. Bräuniger, H; Mehnert, WH; Schlechte, H; Schulze, B; Schwabe, K, 1981) | 0.26 |
| " The usually recommended dosage schedule is 1 g every 6 hours." | ( The influence of renal function on the elimination kinetics of sulbenicillin in man. Borghetti, A; Borghi, L; Canali, M; Coruzzi, P; Montanari, A; Novarini, A, 1980) | 0.26 |
| " Thus a uniform and standard penicillin dosage allowing no safety margin may help in the superficial healing of a syphilitic chancre or the resolution of a roseola but it will certainly be insufficient to kill Treponema pallidum." | ( Kinetic study of serum penicillin concentrations after single doses of benzathine and benethamine penicillins in young and old people. Collart, P; Durel, J; Herlin, A; Milovanovic, A; Poitevin, M, 1980) | 0.26 |
| " The enchancement of killing by pretreatment with cell wall-active antibiotics was present in a dose-response fashion to 1/16th the MIC." | ( Interactions between antibiotics and human neutrophils in the killing of staphylococci. Isturiz, R; Malech, HL; Metcalf, JA; Molavi, A; Root, RK, 1981) | 0.26 |
| " The in-vitro activities, indications, side effects and dosage recommendations of the first choice (clindamycin, metronidazole and ornidazole, cefoxitin, penicillin G) and second choice antibiotics (chloramphenicol, ticarcillin) are discussed." | ( [Therapy of anaerobic infections]. Eijsten, A; Lüthy, R, 1980) | 0.46 |
| "5 min, respectively) and a dosage interval of 6-8 h would be suitable to treat infections caused by susceptible bacteria." | ( Disposition of penicillin G sodium following intravenous and oral administration to Equidae. Horspool, LJ; McKellar, QA, ) | 0.48 |
| " The presence of the postantibiotic sub-MIC effect may be an important factor in determining the dosing regimen for infective endocarditis." | ( Postantibiotic effects and postantibiotic sub-MIC effects of benzylpenicillin on viridans streptococci isolated from patients with infective endocarditis. Enari, T; Haruki, K; Hasegawa, H; Katahira, J; Kikuchi, K; Minami, S; Shibata, Y; Shimizu, K; Totsuka, K, 1994) | 0.29 |
| " The dosage of 360 units/mL penicillin-G had only a modest effect on the growth of the microorganism." | ( Penicillin-G enhanced production of thuringiensin by Bacillus thuringiensis sp. darmstadiensis. Tzeng, YM; Young, YH, ) | 0.13 |
| "Plasma concentration of penicillin G was evaluated in beef steers after administration of either a combination of benzathine penicillin G and procaine penicillin G in a 1:1 mixture at a dosage of 9,000 U/kg of body weight, IM (n = 5), 24,000 U/kg, IM (n = 5), or 8,800 U/kg, SC (n = 5), or benzathine penicillin G alone at a dosage of 12,000 U/kg, IM (n = 7)." | ( Disposition of penicillin G after administration of benzathine penicillin G, or a combination of benzathine penicillin G and procaine penicillin G in cattle. Boison, JO; Janzen, ED; Korsrud, GO; Landry, DA; MacNeil, JD; McKinnon, JJ; Papich, MG; Yates, WD, 1994) | 0.95 |
| " The dose-response curve for GABA in the presence of 10(-3) M PC-G was shifted rightward and there was a decrease in maximum response." | ( Effect of penicillin on GABA-gated chloride ion influx. Ito, M; Kishi, K; Mori, C; Shiraishi, H; Tsuda, A; Tsuda, H, 1994) | 0.29 |
| " Aqueous penicillin G (A-PEN), 100,000 U/kg per day, was used in 23 infant, and a dosage of 200,000 U/kg per day was used in 40 patients; procaine penicillin G (P-PEN), 50,000 U/kg per day, was used in 100 children." | ( Concentrations of procaine and aqueous penicillin in the cerebrospinal fluid of infants treated for congenital syphilis. Azimi, PH; Berman, SM; Berne, P; Franklin, L; Fulroth, R; Janner, D; Lvoff, V, 1994) | 0.71 |
| " After operation the patient became asymptomatic on treatment with low dosage pyridostigmine (3 x 30 mg)." | ( [Myasthenia gravis in AIDS and neurosyphilis]. Hagenah, R; Schneider, U; Wüllenweber, M, 1993) | 0.29 |
| " For each drug, 13-18 groups (n = 5-10 individuals/group) of the dosed animals were killed at different post-dosing times." | ( Comparative plasma and tissue pharmacokinetics and drug residue profiles of different chemotherapeutants in fowls and rabbits. Guo, WX; Hu, GZ; Li, SF; Li, SY; Li, T; Meng, FD; Qiao, GL; Qiu, YS; Yie, HL; Zhang, XY, 1995) | 0.29 |
| " Thirty -six pigs were treated with trimethoprim/sulfatroxazole IM in the nec k at a dosage of 16 mg/kg body weight for five days." | ( [Study of the elimination of residues and local tissue injury following intramuscular injection of a solution of the combination trimethoprim/sulfatroxazole in pigs]. Edwards, HJ; Kissmeyer, AM; Pott, JM; Skov, B; Szancer, J, 1996) | 0.29 |
| " The method was further validated on kidney, liver, and muscle tissues from 2 sheep dosed with Aquacaine G suspension (containing benzylpenicillin)." | ( Liquid chromatographic determination of benzylpenicillin and cloxacillin in animal tissues and its application to a study of the stability at -20 degrees C of spiked and incurred residues of benzylpenicillin in ovine liver. Gee, HE; Ho, KB; Toothill, J, ) | 0.13 |
| " Once-daily dosing (ODD) of aminoglycosides can be recommended in penicillin-sensitive streptococcal endocarditis." | ( [Aminoglycosides in the treatment of infectious endocarditis]. Malinverni, R, 1996) | 0.29 |
| " Our results suggest that, if the label withdrawal period of 10 days is observed, an increase in the dosage of up to three times the recommended rate is unlikely to increase significantly the risk that residues would occur in the tissues of treated hogs at concentrations which exceed MRLs." | ( Residue depletion in tissues and fluids from swine fed sulfamethazine, chlortetracycline and penicillin G in combination. Fesser, AC; Korsrud, GO; MacNeil, JD; Papich, MG; Salisbury, CD, 1996) | 0.51 |
| " The sheep were then dosed intravenously with 26." | ( Pharmacokinetics of penicillin G in plasma and interstitial fluid collected with dialysis fiber bundles in sheep. Bevill, RP; Cooke, IM; Koritz, GD; Nelson, DR, 1996) | 0.62 |
| " three times daily) and tobramycin (80 mg three times daily) for two weeks, followed by penicillin G in the same dosage for four more weeks." | ( [Infectious thyroiditis as initial manifestation of embolizing endocarditis of the aortic valve]. Heufelder, AE; Hofbauer, LC; Spitzweg, C; Tammen, AR, 1996) | 0.52 |
| " Yield increases have been achieved by increasing the dosage of the biosynthetic genes cefEF (deacetoxycephalosporin C expandase/hydroxylase) and cefG (deacetylcephalosporin C acetyltransferase) or enhancing the oxygen uptake by expressing a bacterial oxygen-binding heme protein (Vitreoscilla hemoglobin)." | ( Recombinant Acremonium chrysogenum strains for the industrial production of cephalosporin. Barredo, JL; Díez, B; Fouces, R; Mellado, E; Rodríguez, M, 1996) | 0.29 |
| " The PME may prove to be a more reliable factor than the in vitro postantibiotic effect or postantibiotic sub-MIC effect for the design of optimal dosing schedules, since the PME, like the in vivo postantibiotic effect, includes the effects of subinhibitory concentrations and therefore better reflects the clinical situation with fluctuating antibiotic concentrations." | ( Pharmacodynamic effects of sub-MICs of benzylpenicillin against Streptococcus pyogenes in a newly developed in vitro kinetic model. Bengtsson, S; Cars, O; Löwdin, E; Odenholt, I, 1996) | 0.29 |
| " Concentrations in TCF remained above the minimum inhibitory concentration of Streptococcus zooepidemicus for the proposed dosing intervals of 8, 12 and 24 h for ampicillin sodium, pivampicillin and procaine penicillin G respectively." | ( Distribution of penicillins into subcutaneous tissue chambers in ponies. Barneveld, A; Ensink, JM; Klein, WR; Tukker, JJ; Van Miert, AS; Vulto, AG, 1996) | 0.48 |
| " It is concluded that in both ewes and cows pharmacokinetic parameters of penicillin-G are altered from late pregnancy to early lactation but that these changes have little practical impact and do not call for a revised dosage regime of the studied drug." | ( Pharmacokinetics of penicillin-G in ewes and cows in late pregnancy and in early lactation. Bengtsson, B; Franklin, A; Jacobsson, SO; Luthman, J, 1997) | 0.3 |
| " A third explanation for the infrequent use of penicillin is lack of clear consensus dosing guidelines." | ( Penicillin dosing for pneumococcal pneumonia. Bryan, CS; Stinson, MS; Talwani, R, 1997) | 0.3 |
| " The dosage of beta-lactamase during the exponential growth phase has revealed that the strain BS3 produces a maximal amount of this enzyme." | ( [Thermophilic bacteria resistant to antibiotics in traditional public baths]. Filali, FR; Frere, JM; Zaid, A; Zekhnini, Z, 1997) | 0.3 |
| " Different 8 h dosing regimens were applied, with different total doses and initiated at different times during the bacterial growth phase." | ( Pharmacodynamics of penicillin are unaffected by bacterial growth phases of Streptococcus pneumoniae in the mouse peritonitis model. Espersen, F; Frimodt-Møller, N; Knudsen, JD, 1998) | 0.3 |
| "Direct current and differential pulse polarography DPP were used for the determination of three penicillins, namely, ampicillin, benzylpenicillin and carbenicillin, in pure form and in their dosage forms." | ( Polarographic determination of some penicillins through nitrosation. Belal, F; Eid, M; Rizk, MS, 1998) | 0.3 |
| " A dose-response profile for penicillin G was constructed by analysis of spiked milk samples." | ( A novel rapid enzyme immunoassay (Fluorophos BetaScreen) for detection of beta-lactam residues in ex-farm raw milk. Johnsson, G; Sternesjö, A, 1998) | 0.59 |
| " Group 2 received placebo in a similar dosing schedule." | ( Antibiotic prophylaxis in orthognathic surgery: a 1-day versus 5-day regimen. Aiello, GA; Bentley, KC; Head, TW, 1999) | 0.3 |
| " Although the appropriate selection of mouse strains and drug dosage levels has to be considered, these results suggest that the PLNA may be an appropriate screening system for prediction of the allergic or autoimmunity-inducing potentials of low-molecular-weight drugs." | ( Mouse popliteal lymph node assay for assessment of allergic and autoimmunity-inducing potentials of low-molecular-weight drugs. Iwaki, Y; Kamimura, Y; Kuninishi, Y; Maki, E; Nakamura, K; Nishida, H; Shinkai, K; Suzuki, R; Takahashi, K; Takahashi, M; Tsutsui, N; Vohr, HW, 1999) | 0.3 |
| "PenG did not alter the expression of the investigated mRNA, independently of the dosage and the incubation times used." | ( Penicillin G does not alter collagen type I metabolism of dermal fibroblasts in culture. Anderegg, U; Haustein, UF; Wilczek, A, 2000) | 1.75 |
| "Although the efficacy of penicillin treatment for syphilis has been amply demonstrated, the optimal, curative dosage is still undefined." | ( Treatment of latent and tertiary syphilis. Augenbraun, M, 2000) | 0.31 |
| " The dosing interval should be 4 hours to ensure anti-GBS activity in all patients." | ( Optimal dosing of penicillin G in the third trimester of pregnancy for prophylaxis against group B Streptococcus. Cho, E; Colombo, DF; Fan-Havard, P; Gardner, D; Johnson, JR; Shellhaas, CS, 2001) | 0.64 |
| " In addition, concurrent dosing of BPAA (1 microgram/body) did not reduce the convulsion-inducing dose of PZFX mesilate." | ( [Drug interactions between nonsteroidal anti-inflammatory drug and pazufloxacin mesilate, a new quinolone antibacterial agent for intravenous use: convulsions in mice after intravenous or intracerebroventricular administration]. Fukuda, H; Kawamura, Y, 2002) | 0.31 |
| "Optimizing pharmacokinetic/pharmacodynamic indices of antibiotics to obtain clinical and microbiological efficacy is essential, but dosing regimens must also be tailored to minimize the risk for emergence of resistance." | ( Suboptimal antibiotic dosage as a risk factor for selection of penicillin-resistant Streptococcus pneumoniae: in vitro kinetic model. Cars, O; Gustafsson, I; Löwdin, E; Odenholt, I, 2003) | 0.32 |
| " In the control group, 20 sows were intramuscularly injected with a standard dosage of penicillin G (400,000 IU/head) once a day for 3 consecutive days." | ( Therapeutic effect of bee venom in sows with hypogalactia syndrome postpartum. Choi, SH; Kang, SS, 2001) | 0.53 |
| " Rabbits were immunosuppressed with cyclosporin A (CsA) at a dosage of 15 mg/kg/day, decreased to 10 mg/kg/day after the fourth week." | ( Efficacy of five human melanocytic cell lines in experimental rabbit choroidal melanoma. Almaraz, A; Blanco, G; Fernández, N; López-Velasco, R; Morilla-Grasa, A; Ordóñez, JL; Rábano, G; Saornil-Alvarez, MA, 2005) | 0.33 |
| " These methods were applied to the analysis of plasma, urine, and kidney biopsy samples taken from standing animals that had been dosed with penicillin." | ( LC/MS/MS measurement of penicillin G in bovine plasma, urine, and biopsy samples taken from kidneys of standing animals. Chiesa, OA; Heller, DN; Smith, ML, 2006) | 0.64 |
| " The semimechanistic model that was developed might, after further refinement, serve as a tool for the development of optimal dosing strategies for antibacterial agents." | ( Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments. Cars, O; Karlsson, MO; Löwdin, E; Nielsen, EI; Sandström, M; Viberg, A, 2007) | 0.34 |
| " Repeated dosing was administered intraperitoneally every 4 to 6 hours for 48 hours." | ( Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model. Betten, DP; Clark, RF; Favata, M; Hernandez, M; Richardson, WH; Riffenburgh, RH; Tanen, DA; Tong, TC, 2007) | 0.34 |
| " Regardless of the response to penicillin skin testing, patients received the usual 1-day dosage of penicillin and amoxicillin, on 2 separate occasions." | ( Skin testing and oral penicillin challenge in patients with a history of remote penicillin allergy. Confino-Cohen, R; Goldberg, A, 2008) | 0.35 |
| "This study was designed to evaluate the penicillin-induced epilepsy model in terms of dose-response relationship of penicillin used to induce epilepsy seizure on hippocampal neuron number and hippocampal volume in Sprague-Dawley rats." | ( Penicillin-induced epilepsy model in rats: dose-dependant effect on hippocampal volume and neuron number. Adiguzel, E; Akdogan, I; Ozdemir, MB; Sahiner, M; Tufan, AC; Yilmaz, I, 2008) | 0.35 |
| " The results demonstrated that simultaneous administration of α-AMA and each of tested antidotes (BPCN, CEFT, RIFSV) effectively protected human hepatocytes; however, in the group dosed with BPCN, the highest hepatocyte viability was observed." | ( Comparative antidotal efficacy of benzylpenicillin, ceftazidime and rifamycin in cultured human hepatocytes intoxicated with α-amanitin. Dziędgiel, P; Gomułkiewicz, A; Magdalan, J; Ostrowska, A; Piotrowska, A; Szeląg, A, 2009) | 0.35 |
| " In both man and rabbit, penicillin X provided higher and more sustained blood levels than did penicillins F or G similarly administered in equal dosage (0." | ( THE VARYING BLOOD LEVELS AFFORDED BY PENICILLINS F, G, K, AND X IN RABBITS AND MAN. Eagle, H, 1947) | 0.23 |
| " To determine if antibiotic residue levels are dependent upon muscle type, seven culled dairy cows were dosed with penicillin G (Pen G) from 1 to 3 days and then sacrificed on day 1, 2, or 5 of withdrawal." | ( Distribution of penicillin G residues in culled dairy cow muscles: implications for residue monitoring. Mastovska, K; Schneider, MJ; Solomon, MB, 2010) | 0.92 |
| "Streptomycin has been available for over 60 years, yet optimal dosing in hemodialysis (HD) patients is not well defined." | ( A successful strategy for the use of synergistic intravenous streptomycin in a hemodialysis patient with refractory Enterococcus faecalis bacteremia. Belknap, R; Jenkins, TC; Swartwood, CJ; Young, H, 2011) | 0.37 |
| " The selection and magnitude of the PK/PD index were, however, shown to be sensitive to differences in PK in subpopulations, uncertainty in MICs, and investigated dosing intervals." | ( Pharmacokinetic/pharmacodynamic (PK/PD) indices of antibiotics predicted by a semimechanistic PKPD model: a step toward model-based dose optimization. Cars, O; Friberg, LE; Nielsen, EI, 2011) | 0.37 |
| " Results of the part I (internal) and part II (independent laboratory) dose-response studies employing spiked samples were in close agreement." | ( Validation study of the BetaStar plus lateral flow assay for detection of beta-lactam antibiotics in milk. Abouzied, M; Ankrapp, D; Driksna, D; Klein, F; Mozola, M; Rice, J; Sarzynski, M; Walsh, A; Walsh, C, ) | 0.13 |
| "The results achieved with 80% reduction in the incidence of early-onset neonatal group B streptococcal (GBS) sepsis following the implementation of the preliminary (1996, 2002) and subsequently the revised (2010) guidelines for intrapartum antibiotic prophylaxis imposed the discussion on a large scale of the updated:--algorithms for GBS screening (35-37 weeks of gestation) with the recommended dosage of penicillin-G for intrapartum antibiotic prophylaxis for women having normal labor and delivery;--algorithms for GBS screening and intrapartum antibiotic prophylaxis for women with preterm labor (PPROM) or premature rupture of membranes (PROM);--intrapartum antibiotic prophylaxis regimens for women with penicillin allergy;--algorithm for management of newborns with respect to risk of early-onset GBS disease." | ( [A study on early-onset group "B" streptococcal neonatal infection]. Decheva, A; Dimitrova, N; Dobreva, A; Kraleva, I; Takova, Ts; Todorova, M; Vacheva, R; Yarakova, N, 2012) | 0.38 |
| " When treating enterococci, therapeutic drug monitoring should be applied to optimize penicillin G dosing and exposure." | ( Penicillin G Treatment in Infective Endocarditis Patients - Does Standard Dosing Result in Therapeutic Plasma Concentrations? Bibby, BM; Brock, B; Hardlei, TF; Jensen, K; Kragh Thomsen, M; Öbrink-Hansen, K; Petersen, E; Wiggers, H, 2017) | 2.12 |
| " The pharmacodynamic parameters based on a wide range of concentrations below and above the MIC provide information that could support improving future dosing strategies to treat gonorrhoea." | ( Time-kill curve analysis and pharmacodynamic modelling for in vitro evaluation of antimicrobials against Neisseria gonorrhoeae. Althaus, CL; Foerster, S; Hathaway, LJ; Low, N; Unemo, M, 2016) | 0.43 |
| " Beta-lactam chemical instability in plasma can cause misleading pharmacokinetic modeling results, which could impact upon model-based dosing recommendations and the forthcoming era of beta-lactam therapeutic drug monitoring." | ( Development of a Novel Multipenicillin Assay and Assessment of the Impact of Analyte Degradation: Lessons for Scavenged Sampling in Antimicrobial Pharmacokinetic Study Design. Barker, CIS; Johnston, A; Kipper, K; Sharland, M; Standing, JF, 2018) | 0.48 |
| "1% would have a PENu concentration greater than the MIC during half of the dosing interval (fT > MIC = 50%), whereas this was 24." | ( Pharmacokinetics and Pharmacodynamic Target Attainment of Benzylpenicillin in an Adult Severely Ill Sub-Saharan African Patient Population. Beirão, JC; Bos, JC; Lang, CN; Mathôt, RAA; Mistício, MC; Nunguiane, G; Prins, JM; van Hest, RM, 2018) | 0.48 |
| " In this setting, dosing data for antibiotics like benzylpenicillin are lacking." | ( Pharmacokinetics of Benzylpenicillin (Penicillin G) during Prolonged Intermittent Renal Replacement Therapy. Allen, C; Chang, T; Cheng, V; Dyer, J; Fox, E; Hoad, K; Litton, E; Page, MM; Rawlins, M; Roberts, JA, 2019) | 0.78 |
| " We determined that when mice were administered intermittent subtherapeutic dosing of benzylpenicillin, the strain with a Pro601Leu amino acid replacement in PBP2X that confers reduced β-lactam susceptibility in vitro was more fit, as assessed by the magnitude of colony-forming units recovered from disease tissue." | ( A Single Amino Acid Replacement in Penicillin-Binding Protein 2X in Streptococcus pyogenes Significantly Increases Fitness on Subtherapeutic Benzylpenicillin Treatment in a Mouse Model of Necrotizing Myositis. Musser, JM; Olsen, RJ; Zhu, L, 2020) | 0.56 |
| "Adequate dosage recommendations are imperative for successful treatment of invasive infections." | ( Benzylpenicillin Serum Concentrations in Neonates With Group B Streptococci Sepsis or Meningitis: A Descriptive Cohort Study. Bekker, V; Bredius, RGM; Jansen, SJ; Lopriore, E; Moes, DJAR; van der Beek, MT, 2021) | 0.62 |
| " Outcomes included numbers of sub- and supratherapeutic concentrations, and dose adjustments, clinical evolution, and dosing recommendations from six pediatric reference sources." | ( Benzylpenicillin Serum Concentrations in Neonates With Group B Streptococci Sepsis or Meningitis: A Descriptive Cohort Study. Bekker, V; Bredius, RGM; Jansen, SJ; Lopriore, E; Moes, DJAR; van der Beek, MT, 2021) | 0.62 |
| " Substantial variation in dosing recommendations (50,000-400,000 IE/kg/d) was present between reference sources." | ( Benzylpenicillin Serum Concentrations in Neonates With Group B Streptococci Sepsis or Meningitis: A Descriptive Cohort Study. Bekker, V; Bredius, RGM; Jansen, SJ; Lopriore, E; Moes, DJAR; van der Beek, MT, 2021) | 0.62 |
| "Our data reveal that under current dosage recommendations, the predefined target serum or CSF concentrations of BPEN are not achieved in all children." | ( Benzylpenicillin Serum Concentrations in Neonates With Group B Streptococci Sepsis or Meningitis: A Descriptive Cohort Study. Bekker, V; Bredius, RGM; Jansen, SJ; Lopriore, E; Moes, DJAR; van der Beek, MT, 2021) | 0.62 |
| "Treatment regimens requiring multiple daily dosing for enterococcal endocarditis are challenging to deliver in the outpatient setting." | ( Outpatient continuous-infusion benzylpenicillin combined with either gentamicin or ceftriaxone for enterococcal endocarditis. Bhally, H; Briggs, S; Broom, M; Duffy, E; Everts, G; Everts, R; Lowe, B; McBride, S, 2021) | 0.62 |
| " The doses or dosing intervals of antimicrobials administered to horses undergoing anesthesia may need to be adjusted to ensure maintenance of safe and effective plasma concentrations." | ( Potassium penicillin and gentamicin pharmacokinetics in healthy conscious and anesthetized horses. Bogers, SH; Council-Troche, RM; Davis, JL; Wilson, KE, 2023) | 0.91 |
| " Each participant's penicillin pharmacokinetic parameters will be established prior to the challenge, to ensure accurate dosing for the continuous infusion." | ( Study protocol for controlled human infection for penicillin G against Barr, R; Batty, KT; Carapetis, J; Enkel, SL; Hla, TK; Kado, J; Manning, L; Marsh, JA; McCarthy, J; Osowicki, J; Salman, S; Snelling, TL; Steer, AC, 2022) | 0.97 |
| Role | Description |
|---|---|
| antibacterial drug | A drug used to treat or prevent bacterial infections. |
| epitope | The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds. |
| drug allergen | Any drug which causes the onset of an allergic reaction. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| penicillin | Any member of the group of substituted penams containing two methyl substituents at position 2, a carboxylate substituent at position 3 and a carboxamido group at position 6. |
| penicillin allergen | Any penicillin which causes the onset of an allergic reaction. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 44.6684 | 1.9953 | 25.5327 | 50.1187 | AID624287 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 1,049.0000 | 1.6000 | 5.7440 | 10.0000 | AID678786; AID679489 |
| Solute carrier family 22 member 8 | Mus musculus (house mouse) | IC50 (µMol) | 89.4000 | 3.0200 | 3.0200 | 3.0200 | AID1209730 |
| Bile salt export pump | Homo sapiens (human) | IC50 (µMol) | 10.0000 | 0.1100 | 7.1903 | 10.0000 | AID1449628 |
| Solute carrier family 15 member 1 | Homo sapiens (human) | Ki | 30,000.0000 | 0.1800 | 3.3933 | 9.8000 | AID238858; AID681115 |
| Beta-lactamase TEM | Escherichia coli | Ki | 20.0000 | 0.0270 | 1.8234 | 7.3000 | AID43582 |
| Solute carrier family 15 member 2 | Homo sapiens (human) | Ki | 10,982.3999 | 0.7943 | 4.2210 | 8.0000 | AID612540 |
| Solute carrier family 15 member 2 | Rattus norvegicus (Norway rat) | Ki | 11,100.0000 | 3.0000 | 6.4778 | 8.5000 | AID681114 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | Ki | 97.6000 | 0.0400 | 4.2297 | 9.0000 | AID681372 |
| Solute carrier family 22 member 8 | Rattus norvegicus (Norway rat) | Ki | 52.8000 | 3.0900 | 5.5400 | 9.1000 | AID679175 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| streptokinase A precursor | Streptococcus pyogenes M1 GAS | EC50 (µMol) | 0.0600 | 0.0600 | 8.9128 | 130.5170 | AID1902 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Beta-lactamase | Citrobacter freundii | Km | 16.0000 | 5.0000 | 7.0000 | 9.0000 | AID405084 |
| Beta-lactamase | Citrobacter gillenii | Km | 51.0000 | 10.0000 | 10.0000 | 10.0000 | AID285442 |
| Beta-lactamase | Escherichia coli | Km | 3.8000 | 1.1000 | 4.7667 | 9.4000 | AID394487 |
| Beta-lactamase | Aeromonas caviae | Km | 206.0000 | 7.0000 | 7.0000 | 7.0000 | AID374363 |
| Beta-lactamase | Shouchella clausii | Km | 12.0000 | 0.0100 | 3.0050 | 6.0000 | AID373209 |
| Beta-lactamase | Acinetobacter baumannii | Km | 3.0000 | 3.0000 | 5.6667 | 9.0000 | AID567279 |
| Beta-lactamase | Burkholderia cenocepacia | Km | 25.0000 | 10.0000 | 10.0000 | 10.0000 | AID541022 |
| Metallo-beta-lactamase type 2 | Klebsiella pneumoniae | Km | 16.0000 | 8.0000 | 9.3333 | 10.0000 | AID563972 |
| Metallo-beta-lactamase VIM-11 | Pseudomonas aeruginosa | Km | 15.3000 | 4.5000 | 7.0000 | 9.4000 | AID520385 |
| Beta-lactamase | Klebsiella pneumoniae | Km | 4.9000 | 3.2000 | 5.8250 | 10.0000 | AID562754 |
| Metallo-beta-lactamase VIM-2 | Pseudomonas aeruginosa | Km | 19.1000 | 5.5000 | 7.8750 | 9.9000 | AID520386 |
| Beta-lactamase | Pseudomonas aeruginosa | Km | 4.0000 | 0.3000 | 2.0063 | 8.0000 | AID495661 |
| Beta-lactamase | Aeromonas allosaccharophila | Km | 200.0000 | 1.5000 | 6.3000 | 10.0000 | AID584846 |
| Metallo-beta-lactamase | Stutzerimonas stutzeri | Km | 90.0000 | 3.5000 | 4.7500 | 6.0000 | AID518728 |
| Beta-lactamase | Acinetobacter baumannii | Km | 12.0000 | 6.0000 | 7.6667 | 10.0000 | AID567280 |
| Solute carrier family 22 member 8 | Mus musculus (house mouse) | Km | 40.0000 | 0.0539 | 2.4065 | 5.5000 | AID681168 |
| Beta-lactamase | Staphylococcus aureus | Km | 7.7000 | 1.0000 | 2.2000 | 3.4000 | AID368313; AID44042 |
| Beta-lactamase | Enterobacter cloacae | Km | 5.9250 | 2.9000 | 6.4364 | 9.8000 | AID368498; AID368523; AID368527; AID495693 |
| Beta-lactamase SHV-1 | Klebsiella pneumoniae | Km | 19.5000 | 4.2000 | 4.2500 | 4.3000 | AID368307; AID495687; AID519746; AID519983 |
| Beta-lactamase OXA-10 | Pseudomonas aeruginosa | Km | 7.9000 | 7.9000 | 7.9000 | 7.9000 | AID495694 |
| Beta-lactamase | Serratia marcescens | Km | 2.1000 | 2.1000 | 2.1000 | 2.1000 | AID368725 |
| Beta-lactamase | Pseudomonas aeruginosa PAO1 | Km | 18.4833 | 0.5000 | 4.2444 | 8.0000 | AID368539; AID368543; AID368547; AID368729; AID495692; AID546426 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | Km | 51.0000 | 10.0000 | 10.0000 | 10.0000 | AID285442 |
| Beta-lactamase TEM | Escherichia coli | Km | 33.0000 | 5.4000 | 6.3000 | 7.2000 | AID238095; AID368309; AID495686 |
| Beta-lactamase | Morganella morganii | Km | 7.9000 | 7.9000 | 7.9000 | 7.9000 | AID368531 |
| B2 metallo-beta-lactamase | Chryseobacterium indologenes | Km | 20.0000 | 3.0000 | 3.0000 | 3.0000 | AID562337 |
| Beta-lactamase | Klebsiella pneumoniae | Km | 8.7000 | 8.7000 | 8.7000 | 8.7000 | AID562755 |
| Beta-lactamase | Salmonella enterica subsp. enterica serovar Westhampton | Km | 10.0000 | 10.0000 | 10.0000 | 10.0000 | AID556340 |
| Efflux transporter | Salmonella enterica subsp. enterica serovar Newport | Km | 0.3000 | 0.1000 | 3.8750 | 10.0000 | AID540966 |
| Metallo-beta-lactamase VIM-2 | Klebsiella pneumoniae | Km | 49.0000 | 5.0000 | 7.5000 | 10.0000 | AID563976 |
| Beta-lactamase | Klebsiella pneumoniae | Km | 0.3000 | 0.1000 | 3.0250 | 7.3000 | AID540967 |
| Beta-lactamase | Klebsiella pneumoniae | Km | 5.0000 | 5.0000 | 7.1667 | 10.0000 | AID519982 |
| Beta-lactamase | Escherichia coli | Km | 2.2000 | 0.0046 | 1.4149 | 4.5000 | AID495691 |
| Beta-lactamase | Pseudomonas luteola | Km | 8.0000 | 7.0000 | 7.5000 | 8.0000 | AID495635 |
| Beta-lactamase | Serratia marcescens | Km | 2.2000 | 2.2000 | 4.6000 | 8.2000 | AID368509; AID495696 |
| Beta-lactamase | Klebsiella pneumoniae | Km | 700.0000 | 1.0000 | 4.4500 | 7.9000 | AID1320835 |
| Beta-lactamase IMP-1 | Pseudomonas aeruginosa | Km | 550.0000 | 6.5000 | 6.5000 | 6.5000 | AID495698 |
| BlaVIM-1 | Escherichia coli | Km | 850.0000 | 1.5000 | 1.5000 | 1.5000 | AID495914 |
| Beta-lactamase | Pseudomonas aeruginosa | Km | 35.0000 | 0.5000 | 2.7500 | 5.0000 | AID546429 |
| Beta-lactamase | Escherichia coli | Km | 8.7000 | 7.1000 | 8.1667 | 8.7000 | AID368492; AID495688 |
| Carbapenem-hydrolyzing beta-lactamase KPC | Klebsiella pneumoniae | Km | 30.0000 | 1.6000 | 3.8000 | 6.0000 | AID495695 |
| Beta-lactamase class B VIM-2 | Pseudomonas aeruginosa | Km | 130.0000 | 2.0000 | 6.6500 | 9.4000 | AID368514; AID495697; AID529659; AID531315 |
| Beta-lactamase | Acinetobacter baumannii | Km | 20.0000 | 1.3000 | 3.8000 | 9.6000 | AID495699; AID495700 |
| Solute carrier family 22 member 8 | Rattus norvegicus (Norway rat) | Km | 82.6000 | 0.7390 | 1.5395 | 2.3400 | AID681390 |
| Beta-lactamase VIM-1 | Pseudomonas aeruginosa | Km | 1,303.0000 | 4.0000 | 4.0000 | 4.0000 | AID530340 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID562610 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID278681 | Antibacterial activity against Enterococcus faecium isolate 5752 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID495693 | Activity of Enterobacter cloacae AmpC | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID573583 | Antibacterial activity against beta-lactamase producing Bacteroides caccae assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1054741 | Antibacterial activity against Pseudomonas aeruginosa ATCC 13525 assessed as growth inhibition after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Schiff's base derivatives bearing nitroimidazole moiety: new class of antibacterial, anticancer agents and potential EGFR tyrosine kinase inhibitors. |
| AID511291 | Activity of Pseudomonas aeruginosa GES-13 beta lactamase assessed as hydrolysis by spectrometry | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID528730 | Antibacterial activity against penicillin resistant Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID587963 | Activity of Escherichia coli beta-lactamase Toho-1 D240S mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID770972 | Antibacterial activity against Staphylococcus epidermidis MTCC 435 by broth dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Demonic axe-like conjugated alkynes in combating microbes. |
| AID588119 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID150757 | P-gp activity was measured by a direct transport assay, using polarized LLC-MDR1 epithelial cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID559057 | Antibacterial activity against Lancefield Streptococcus sp. 'group G' by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID418560 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents. |
| AID1287890 | Antimicrobial activity against Bacillus sphaericus MTCC 11 after 24 hrs by serial two-fold broth dilution method | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline-thiazolidine-based hybrids. |
| AID418557 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis ATCC 51625 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents. |
| AID573138 | Antibacterial activity against erythromycin-susceptible Streptococcus agalactiae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID524881 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA, penB, ponA and mtrR mutant gene assessed as incidence of resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID542628 | Antimicrobial activity against streptomycin-resistant Streptococcus pneumoniae R6 harboring PBP2x2349 mutant gene and Janus disruption at PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID569342 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID522643 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis Sterne by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID399188 | Antibacterial activity against Staphylococcus aureus ATCC 6538 P at below 625 ug/mL after 24 hrs by broth microdilution method | 2004 | Journal of natural products, Jan, Volume: 67, Issue:1 | Africane-type sesquiterpenoids from the Argentine liverwort Porella swartziana and their antibacterial activity. |
| AID379709 | Antibacterial activity against Bacillus cereus by modified microtiter plate assay | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Bioactive natural and semisynthetic latrunculins. |
| AID557489 | Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID520725 | Activity of Acinetobacter baumannii MAD beta-lactamase assessed per mg of protein at 100 uM | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID531452 | Antibacterial activity against Streptococcus pneumoniae serotype 22 assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID531315 | Activity of Pseudomonas aeruginosa beta-lactamase VIM-2 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID509630 | Antimicrobial activity against Staphylococcus aureus RN4220 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID335712 | Antibacterial activity against Bacillus subtilis ATCC 9372 after 2 days by twofold serial dilution method | 1992 | Journal of natural products, Oct, Volume: 55, Issue:10 | Antibacterial activity of totarol and its potentiation. |
| AID559058 | Antibacterial activity against levofloxacin-susceptible Streptococcus pneumoniae by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID575946 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae assessed as susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. |
| AID609860 | Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Unprecedented C-2 arylation of indole with diazonium salts: Syntheses of 2,3-disubstituted indoles and their antimicrobial activity. |
| AID557514 | Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID340769 | Increase in pbp1B gene expression in penicillin-resistant Streptococcus gordonii with penicillin binding protein PR1_2 evolved mutation assessed as relative luciferase units relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID625530 | Antimicrobial activity against Pseudomonas aeruginosa MTCC 741 by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Iodine-catalyzed conjugate addition of indoles onto en-1,4-dione: a novel synthesis of 3-(1-(1H-indol-3-yl)-2-oxo-2-phenylethyl)indolin-2-ones as antibacterial and antifungal agents. |
| AID529663 | Activity of Pseudomonas aeruginosa 166301 beta-lactamase VIM-16 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID573594 | Antibacterial activity against Fusobacterium varium assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID520392 | Antibacterial activity against mef and erm(B) positive Streptococcus pneumoniae isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID528523 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC 12403 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID531313 | Activity of Pseudomonas aeruginosa beta-lactamase VIM-7 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID572273 | Antimicrobial activity against Streptococcus pneumoniae ATCC 6303 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID679518 | TP_TRANSPORTER: inhibition of PAH uptake (PAH: 2 uM, PCG: 2000 uM) in Xenopus laevis oocytes | 1999 | The American journal of physiology, 01, Volume: 276, Issue:1 | Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. |
| AID1565596 | Antibacterial activity against Bacillus subtilis ATCC 23857 after 18 hrs by CLSI based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity. |
| AID269445 | Antibacterial activity against MRSA Staphylococcus aureus 134/93 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID573152 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID545144 | Activity of CMY-2 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID508382 | Antibacterial activity against Streptococcus pyogenes harboring erm(B) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID372626 | Ratio of Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-12 to Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-158 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID495694 | Activity of Pseudomonas aeruginosa OXA-10 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID562411 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group G clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID341522 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 52 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID279187 | Ratio of kcat to Km of Enterobacter cloacae S3 isolate beta lactamase LAP1 expressed in Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID295110 | Antibacterial activity against Bacillus cereus ATCC 7064 at 10 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID322511 | AUC (0 to 12) in human adults at 600 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID368507 | Ratio of Kcat to Km of Escherichia coli KPC2 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID519995 | Antimicrobial activity against Streptococcus pneumoniae harboring erm(B) and mef(A) gene | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID625282 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID587733 | Ratio of Kcat to Km for Pseudomonas aeruginosa strain PS 297 metallo-beta-lactamase IMP-1 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis using 100 uM nitrocefin | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID573149 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID770969 | Antibacterial activity against Klebsiella pneumoniae MTCC 618 by broth dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Demonic axe-like conjugated alkynes in combating microbes. |
| AID1548179 | Anti-chlamydial activity against Chlamydia trachomatis Serovar LGV-L2 infected in Hep2 cells assessed as reduction in chlamydial inclusion growth by measuring appearance of small and irregular inclusions at 3 ug/ml treated at 8 hrs post-infection and 24 h | 2020 | Journal of medicinal chemistry, 04-23, Volume: 63, Issue:8 | Synthesis and Antichlamydial Activity of Molecules Based on Dysregulators of Cylindrical Proteases. |
| AID341347 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 1 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID368515 | Ratio of Kcat to Km of Pseudomonas aeruginosa IMP1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID531565 | Antibacterial activity against Enterococcus faecalis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID322496 | Cmin in human very low birth weight preterm neonates at 28 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID528728 | Antibacterial activity against Streptococcus pyogenes group A clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID558536 | Antibacterial activity against bla gene-negative and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P854 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID351189 | Apparent peripheral volume of distribution in preterm neonates with septicemia or invasive infections with gestational age of less than 32 weeks at 50000 U/kg, iv administered every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks. |
| AID94369 | In vitro antimicrobial activity against Klebsiella pneumoniae NCTC 418 was determined | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Design, synthesis, and SAR of novel carbapenem antibiotics with high stability to Xanthomonas maltophilia oxyiminocephalosporinase type II. |
| AID558325 | Antibacterial activity against bla gene-negative and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P850 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID584846 | Activity at Aeromonas allosaccharophila AL-1 beta-lactamase PER6 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID557268 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae 3413 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID531458 | Antibacterial activity against Streptococcus pneumoniae serotype 23A assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID565734 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group C clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID531573 | Antibacterial activity against Staphylococcus intermedius obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1279016 | Antibacterial activity against Escherichia coli CCM 4517 after 48 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID332339 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 375 after 18 hrs by microbroth dilution method | 2003 | Journal of natural products, Feb, Volume: 66, Issue:2 | Antibacterial diterpenes from Calceolaria pinifolia. |
| AID528729 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID561513 | Antibacterial activity against Beta-hemolytic Streptococcus group B by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID372617 | Activity of Escherichia coli CF0042 beta-lactamase TEM-35 by microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID368725 | Activity of Serratia marcescens AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID535762 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 05-042 expressing beta-lactamase TEM-1, MLST type ST-1588 and MAST type ST-4012 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID542621 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring wild type PBP2x, disruption in PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID1601847 | Antibacterial activity against Escherichia coli CMCC 25922 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID573581 | Antibacterial activity against beta-lactamase producing Bacteroides caccae by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID625280 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID524042 | Antibacterial activity against methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID341523 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 15 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID1191511 | Antibacterial activity against Staphylococcus aureus CCM 4516/08 after 24 hrs by broth microdilution method | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates. |
| AID451352 | Antimicrobial activity against Escherichia coli ATCC 11775 after 24 hrs by broth dilution method | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. |
| AID535647 | Antimicrobial activity against Group B Streptococcus serotype V 2603 V/R harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID368531 | Activity of Morganella morganii AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID564229 | Ratio of Kcat to Km for Escherichia coli TOP10 beta-lactamase OXA-143 | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID1755807 | Antibacterial activity against Bacillus subtilis ATCC 6633 incubated for 24 hrs by two fold serial dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID573397 | Antibacterial activity against beta-lactamase producing Bacteroides thetaiotaomicron by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID558535 | Antibacterial activity against bla gene-negative and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P843 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID561342 | Antibacterial activity against Beta-hemolytic Streptococcus group A by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID437461 | Antimicrobial activity Streptococcus faecalis ATCC 9790 by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors. |
| AID531578 | Antibacterial activity against Lactococcus lactis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID543284 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x, pbp2b, murM and Streptococcus pneumoniae 72521 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID532677 | Antimicrobial activity against ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates assessed as intermediate resistant isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal. |
| AID1072983 | Antimicrobial activity against Escherichia coli MB 5746 harboring envA/tolC gene after 20 hrs by 2-fold serial broth dilution method | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Isolation, structure elucidation, and biological activity of altersolanol P using Staphylococcus aureus fitness test based genome-wide screening. |
| AID1647684 | Antibacterial activity against Staphylococcus aureus ATCC 12600 assessed as reduction in microbial growth after 24 hrs by agar well diffusion assay | 2020 | Journal of natural products, 02-28, Volume: 83, Issue:2 | Isolation, Identification, and Decomposition of Antibacterial Dialkylresorcinols from a Chinese |
| AID508302 | Inhibition of PBP1 in wild type Enterococcus faecium D63 membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID1191528 | Selectivity index, ratio of IC50 for human HepG2 cells to MIC for Staphylococcus aureus CCM 4516/08 | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates. |
| AID531445 | Antibacterial activity against Streptococcus pneumoniae serotype 6A/C assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID562375 | Antimicrobial activity against erythromycin-susceptible Streptococcus pyogenes clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID585178 | Activity of Beta-lactamase GES-5 E104, S170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID1870129 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4461/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID522661 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis K1938 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID511443 | Antimicrobial activity against Streptococcus uberis ATCC 8749 harboring PAP1A R273H, PBP2B N366I/T402I and PBP2X E381K/Q554E mutation after 16 passages assessed as inhibition of visible growth by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID559704 | Antimicrobial activity against Pseudomonas aeruginosa AB92037 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID529319 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae serotype 23 URA3558 harboring mutant PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID524065 | Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID278560 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium bifidum BB12 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID528727 | Antibacterial activity against Streptococcus agalactiae group B clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID558338 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1730 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID554876 | Antimicrobial activity against Streptococcus pneumoniae serotype 4 ST 205 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID559517 | Antibacterial activity against Streptococcus bovis assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID572271 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus NB01021 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID531569 | Antibacterial activity against Streptococcus sp. 'group C' obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID588118 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB G120K, A121D mutant gene, PBP2 XXXVI pattern, deletion of nucleotide A from mtrA promoter, MAST 3596 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID322506 | Volume of distribution at steady state in human term neonates at 15 mg/kg, im administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID295098 | Antibacterial activity against Staphylococcus aureus ATCC 6538 at 10 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID559076 | Antibacterial activity against ciprofloxacin-susceptible Haemophilus influenzae by CLSI M7-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID560702 | Activity of Escherichia coli MC4100 Beta-Lactamase CMY-2 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID599147 | Antibacterial activity against Escherichia coli after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Mar, Volume: 43, Issue:3 | Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. |
| AID634232 | Antibacterial activity against Fusobacterium nucleatum ATCC 25586 assessed as growth inhibition at 0.00625 to 2.5 ug/ml ug/ml after 24 hrs by microplate dilution assay | 2011 | Journal of natural products, Dec-27, Volume: 74, Issue:12 | Isoflavonoids and coumarins from Glycyrrhiza uralensis: antibacterial activity against oral pathogens and conversion of isoflavans into isoflavan-quinones during purification. |
| AID679174 | TP_TRANSPORTER: uptake in OATP-D-expressing HEK293 cells | 2000 | Biochemical and biophysical research communications, Jun-24, Volume: 273, Issue:1 | Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. |
| AID373210 | Ratio of Kcat to Km for Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID535642 | Antimicrobial activity against Group B streptococcus serotype VI N4 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID335713 | Antibacterial activity against Brevibacterium ammoniagenes ATCC 6872 after 2 days by twofold serial dilution method | 1992 | Journal of natural products, Oct, Volume: 55, Issue:10 | Antibacterial activity of totarol and its potentiation. |
| AID573823 | Antibacterial activity against beta-lactamase producing Clostridium paraputrificum by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1254302 | Antibacterial activity against Staphylococcus epidermidis H 6966/08 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID681035 | TP_TRANSPORTER: inhibition of Ochratoxin A uptake (OTA: 1 uM, PCG: 200 uM) in OAT3-expressing S2 cells | 2001 | Life sciences, Sep-21, Volume: 69, Issue:18 | Characterization of ochratoxin A transport by human organic anion transporters. |
| AID493654 | Antimicrobial activity against Staphylococcus aureus ATCC 6538 by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors. |
| AID531446 | Antibacterial activity against Streptococcus pneumoniae serotype 3 assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1511410 | Antibacterial activity against Staphylococcus aureus assessed as reduction in bacterial cell growth incubated for 24 hrs by filter paper assay | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21 | Synthesis and biological evaluation of calycanthaceous alkaloid analogs. |
| AID558318 | Antibacterial activity against Campylobacter jejuni by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID219756 | In vitro antimicrobial activity against Xanthomonas maltophilia GN 12873 was determined | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Design, synthesis, and SAR of novel carbapenem antibiotics with high stability to Xanthomonas maltophilia oxyiminocephalosporinase type II. |
| AID619679 | Antimicrobial activity against Enterococcus faecalis ATCC 29212 by broth microdilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives. |
| AID372900 | Antibacterial activity against Enterobacter cloacae ATCC 13047 after 24 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Apr, Volume: 44, Issue:4 | Synthesis, characterization and structure-activity relationship analysis of novel depsides as potential antibacterials. |
| AID1638906 | Antimicrobial activity against multidrug-resistant Pseudomonas aeruginosa ATCC BAA-2108 measured after 18 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action. |
| AID561254 | Antibacterial activity against Streptococcus pyogenes assessed as susceptible isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID521825 | Antimicrobial activity against beta-lactam resistant Streptococcus pneumoniae clinical isolate by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID1180452 | Antimicrobial activity against Enterococcus sp. J 14365/08 after 48 hrs by microdilution method | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates. |
| AID1180449 | Antimicrobial activity against Staphylococcus epidermidis H 6966/08 after 24 hrs by microdilution method | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates. |
| AID530510 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 6138-03 expressing pbp2x Q557E mutant and multilocus sequence type ST19 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID530512 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 8607-03 expressing pbp2x Q557E mutant and multilocus sequence type ST19 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID495708 | Kcat/Km ratio of Enterobacter cloacae AmpC | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID524984 | Antibacterial activity against penicillin susceptible Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID520414 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID324848 | Antimicrobial activity against Neisseria gonorrhoeae 90 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID447053 | Antibacterial activity against Escherichia coli ATCC 11230 at 10 IU after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID1076534 | Cytotoxicity against human macrophages after 24 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity. |
| AID287376 | Antibacterial activity against Proteus vulgaris after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID425867 | Antimicrobial activity against Carnobacterium divergens BM4490 expressing beta-lactamase CAD1 at 0.5 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID495718 | Activity of Escherichia coli CTX-M-15 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID559514 | Antibacterial activity against non-levofloxacin susceptible Streptococcus pneumoniae assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID508383 | Antibacterial activity against Streptococcus pyogenes harboring mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID573156 | Antibacterial activity against vancomycin-resistant Enterococcus faecium assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID587964 | Activity of Escherichia coli beta-lactamase Toho-1 D240A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID1237608 | Antibacterial activity against Pseudomonas aeruginosa ATCC2785 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID548534 | Antimicrobial activity against viridans group Streptococcus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID574050 | Antibacterial activity against beta-lactamase producing Finegoldia magna by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID520883 | Activity of Achromobacter xylosoxidans CIP69598 beta-lactamase OXA-114a expressed in Escherichia coli TOP10 assessed as compound hydrolysis | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID171257 | Concentration of compound in rat liver after intravenous injection of 20 mg/kg benzyl-penicillin after 1 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID533929 | Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus NRS127 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID495714 | Kcat/Km ratio of Pseudomonas aeruginosa SPM-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID1347491 | Antibacterial activity against Escherichia coli assessed as zone of inhibition after 24 to 48 hrs by well diffusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations. |
| AID520385 | Activity at Pseudomonas aeruginosa M5109 metallo-beta-lactamase VIM-11 by spectrometry | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID666778 | Antibacterial activity against Escherichia coli at 0.05 mg by agar diffusion test | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13 | Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. |
| AID519631 | Activity of Brachyspira pilosicoli beta-lactamase OXA-63 expressed in Escherichia coli BL21 (DE3) assessed as compound hydrolysis by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID560703 | Ratio of Kcat to Km for Escherichia coli MC4100 Beta-Lactamase CMY-2 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID278566 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum P/N 601377 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID522663 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis SPS 0053 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID585177 | Activity of Beta-lactamase GES-2 E104, N170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID278684 | Antibacterial activity against Enterococcus faecalis isolate 5746 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID557524 | Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID558323 | Antibacterial activity against Campylobacter jejuni isolate P270 harboring blaOXA-61::cat gene by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID625290 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID171110 | Concentration of compound in rat blood after intravenous injection of 20 mg/kg benzyl-penicillin after 3 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID559519 | Antibacterial activity against Streptococcus intermedius assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID599148 | Antibacterial activity against Pseudomonas fluorescens after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Mar, Volume: 43, Issue:3 | Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. |
| AID494345 | Antibacterial activity against Bacillus subtilis by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis, characterization and antimicrobial studies of 2-(4-methoxy-phenyl)-5-methyl-4-(2-arylsulfanyl-ethyl)-2,4-dihydro-[1,2,4] triazolo-3-ones and their corresponding sulfones. |
| AID528608 | Ratio of Kcat to Km for Escherichia coli 2138 beta-lactamase KPC-2 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID422496 | Activity of Carnobacterium divergens BM4489 penicillinase Cad-1 assessed as initial rate of hydrolysis by spectrophotometer | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID520723 | Activity of Acinetobacter baumannii phenotype 1 beta-lactamase assessed per mg of protein at 100 uM | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID573134 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus pyogenes by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID625289 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID569344 | Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID322517 | Effect on glomerular filtration in human very low birth weight preterm neonates urine assessed as drug clearance at 15 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID508369 | Antibacterial activity against Streptococcus pneumoniae harboring erm(B) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID575146 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate NRS123 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID531424 | Antibacterial activity against Streptococcus pneumoniae serotype 33 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID587965 | Activity of Escherichia coli beta-lactamase Toho-1 C69A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID395345 | Antibacterial activity against Bacillus cereus ATCC 7064 at 10 units after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID524974 | Antibacterial activity against Streptococcus sp. Group C clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID381177 | Antibacterial activity against Escherichia coli after 24 to 72 hrs by disk diffusion method | 1999 | Journal of natural products, Sep, Volume: 62, Issue:9 | Antimicrobial and antitumor activities of mycosporulone. |
| AID1565593 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 18 hrs by CLSI based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity. |
| AID533880 | Antibacterial activity against cefotaxime-intermediate Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID495687 | Activity of Klebsiella pneumoniae SHV-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID520408 | Antimicrobial activity against trimethoprim-sulfamethoxazole-resistant Streptococcus pneumoniae by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID1870121 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4880/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID530517 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype V isolate 3386-05 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID559510 | Antibacterial activity against Lancefield Streptococcus sp. 'group C' assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID368727 | Ratio of Kcat to Km of Serratia marcescens AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID577461 | Inhibition of Bocillin FL binding to PBP2b Thr446Ala mutant in laboratory-derived Streptococcus pneumoniae isolate R6 | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID511533 | Antimicrobial activity against Streptococcus uberis isolate 20592 harboring and PBP2X E381K/Q554E mutation assessed as inhibition of visible growth after 24 hrs by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID559059 | Antibacterial activity against non-levofloxacin susceptible Streptococcus pneumoniae by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID495744 | Kcat/Km ratio of Pseudomonas aeruginosa SPM-1 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID69322 | MIC against aerobic organism Escherichia coli strain 2891 | 1982 | Journal of medicinal chemistry, Apr, Volume: 25, Issue:4 | Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain. |
| AID562371 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group C clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID588105 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB G120K, A121D mutant gene, PBP1 L421P mutant gene, PBP2 XXXVIII pattern, deletion of nucleotide A from mtrA promoter, MAST 3563 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID285266 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM151 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID540209 | Volume of distribution at steady state in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID519012 | Activity of Beta-lactamase TEM-10 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID573783 | Antibacterial activity against Prevotella buccae by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID278555 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum P/N 601377 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID324845 | Antimicrobial activity against Neisseria gonorrhoeae 59 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID340848 | Increase in pbp2X gene expression in penicillin-resistant Streptococcus gordonii with penicillin binding protein PR1_2 evolved mutation assessed as relative luciferase units relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID278432 | Antibacterial activity against Streptococcus pyogenes M12 by time-kill curve assay | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments. |
| AID495690 | Activity of Klebsiella pneumoniae Beta-lactamase TEM-26 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID1287891 | Antimicrobial activity against Staphylococcus aureus MTCC 96 after 24 hrs by serial two-fold broth dilution method | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline-thiazolidine-based hybrids. |
| AID1870125 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4566/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID368488 | Ratio of Kcat to Km of Escherichia coli TEM1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID381181 | Antibacterial activity against Streptococcus faecalis after 24 to 72 hrs by disk diffusion method | 1999 | Journal of natural products, Sep, Volume: 62, Issue:9 | Antimicrobial and antitumor activities of mycosporulone. |
| AID682277 | TP_TRANSPORTER: inhibition of Carnitine uptake (Carnitine: 0.02 uM, PCG: 2500 uM) in OCTN2-expressing HeLa cells | 2000 | The Journal of biological chemistry, Jan-21, Volume: 275, Issue:3 | beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. |
| AID529315 | Antibacterial activity against tetracycline- erythromycin- clindamycin-resistant Streptococcus pneumoniae serotype 6B URA4376 harboring mutant PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID278567 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium thermophilum ATCC 25866 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID483192 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by microbroth dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID558626 | Antimicrobial activity against Streptococcus pneumoniae isolate 3481 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1245117 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 13525 after 18 hrs by broth microdilution method | 2015 | Bioorganic & medicinal chemistry, Sep-15, Volume: 23, Issue:18 | Design, synthesis and molecular docking of salicylic acid derivatives containing metronidazole as a new class of antimicrobial agents. |
| AID571186 | Antibacterial activity against Neisseria gonorrhoeae harboring wild-type GA and wild-type penA genes by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID495843 | Ratio of Kcat to Km for Escherichia coli DH10B beta-lactamase VIM-2 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID575082 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID524647 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA, penB and ponA mutant gene assessed as incidence of susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID405084 | Activity of Citrobacter freundii PER2 beta lactamase | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID561249 | Antibacterial activity against Streptococcus pneumoniae by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID495686 | Activity of Escherichia coli TEM-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID518728 | Activity of Pseudomonas stutzeri beta-lactamase DIM-1 by UV-spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID573116 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1243291 | Antimicrobial activity against Escherichia coli ATCC 25922 by standard broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Synthesis and biological evaluation of levofloxacin core-based derivatives with potent antibacterial activity against resistant Gram-positive pathogens. |
| AID540177 | Antibacterial activity against Bacillus subtilis NCIM 2439 after 24 hrs by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and anti-tubercular and antimicrobial activities of some 2r,4c-diaryl-3-azabicyclo[3.3.1]nonan-9-one N-isonicotinoylhydrazone derivatives. |
| AID528705 | Antibacterial activity against Streptococcus mitis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID661940 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 24 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11 | Synthesis and antimicrobial activities of structurally novel S,S'-bis(heterosubstituted) disulfides. |
| AID620346 | Antibacterial activity against Staphylococcus aureus RCMB 000106 at 30 ug/ml after 24 hrs by diffusion agar technique | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Synthesis and anti-microbial activity of some 1- substituted amino-4,6-dimethyl-2-oxo-pyridine-3-carbonitrile derivatives. |
| AID625447 | Antimicrobial activity against Staphylococcus epidermidis by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Iodine-catalyzed conjugate addition of indoles onto en-1,4-dione: a novel synthesis of 3-(1-(1H-indol-3-yl)-2-oxo-2-phenylethyl)indolin-2-ones as antibacterial and antifungal agents. |
| AID533934 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus CM/05 3067 harboring chromosomal cfr gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID524662 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA mutant gene assessed as percentage intermediate isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID285268 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM152 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID573819 | Antibacterial activity against Veillonella parvula by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID588110 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB G120K, A121D mutant gene, PBP2 XXXVIII pattern, deletion of nucleotide A from mtrA promoter, MAST 3158 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID682061 | TP_TRANSPORTER: uptake in OATP-C-expressing HEK293 cells | 2000 | Biochemical and biophysical research communications, Jun-24, Volume: 273, Issue:1 | Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. |
| AID1191512 | Antibacterial activity against Staphylococcus aureus CCM 4516/08 after 48 hrs by broth microdilution method | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates. |
| AID577452 | Antimicrobial activity against penicillin resistant Streptococcus pneumoniae isolate 8819 harboring PBP2b 443SSNA mutant by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID1191514 | Antibacterial activity against methicillin-resistant Staphylococcus aureus H 5996/08 after 48 hrs by broth microdilution method | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates. |
| AID519203 | Antibacterial activity against Streptococcus pneumoniae assessed as susceptible isolates by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | In vitro activity of AR-709 against Streptococcus pneumoniae. |
| AID1254311 | Antibacterial activity against ESBL-positive Klebsiella pneumoniae J 14368/08 after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID533938 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus 425 harboring G2447U in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID634233 | Antibacterial activity against Porphyromonas gingivalis ATCC 33277 assessed as growth inhibition at 0.00625 to 2.5 ug/ml ug/ml after 24 hrs by microplate dilution assay | 2011 | Journal of natural products, Dec-27, Volume: 74, Issue:12 | Isoflavonoids and coumarins from Glycyrrhiza uralensis: antibacterial activity against oral pathogens and conversion of isoflavans into isoflavan-quinones during purification. |
| AID524983 | Antibacterial activity against Streptococcus sp. clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID1546105 | Antimicrobial activity against Bacillus subtilis | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID520729 | Activity of Acinetobacter baumannii CIP7010 beta-lactamase OXA-97 assessed per mg of protein at 100 uM | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID559083 | Antibacterial activity against Neisseria meningitidis by CLSI M7-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID562755 | Activity of Klebsiella pneumoniae AH27 CTX-M-15 beta-lactamase | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID571179 | Antibacterial activity against Neisseria gonorrhoeae harboring wild-type GA gene by disk agar diffusion method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID245438 | Minimum inhibitory concentration against Bacillus subtilis (Gram-positive) was determined by by broth dilution method | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of 2,4,6-tri substituted s-triazines. |
| AID561257 | Antibacterial activity against Streptococcus agalactiae by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID336566 | Antibacterial activity against penicillin-susceptible Staphylococcus aureus ATCC 12598 after 2 days by twofold serial dilution method | 1992 | Journal of natural products, Oct, Volume: 55, Issue:10 | Antibacterial activity of totarol and its potentiation. |
| AID341345 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 4 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID508384 | Antibacterial activity against Streptococcus pyogenes harboring erm(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID545143 | Ratio of Kcat to Km for Klebsiella pneumoniae cephalosporinase CMY-36 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID511441 | Antimicrobial activity against Streptococcus uberis ATCC 19436 harboring PAP1A A227T/G386R, PBP2B N366I/T402I and PBP2X E381K/D524A/Q554E mutation after 30 passages assessed as inhibition of visible growth by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID1076536 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity. |
| AID520730 | Activity of Escherichia coli DH10B beta-lactamase assessed per mg of protein at 100 uM | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID559064 | Antibacterial activity against Streptococcus intermedius by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID546426 | Activity at Pseudomonas aeruginosa PDC-1 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID368509 | Activity of Serratia marcescens SME3 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID529575 | Activity of Erwinia carotovora subsp. atroseptica DSM 30184 beta-lactamase CAR-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID278858 | Antiproliferative effect against MG63 cells assessed as BrdU incorporation into DNA after 48 hrs after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID658950 | Antibacterial activity against Staphylococcus aureus 155554A at 100 mg/ml after 24 hrs by agar-well diffusion technique | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | 2-Aminothiophenes as building blocks in heterocyclic synthesis: synthesis and antimicrobial evaluation of a new class of pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and pyridin-2-one derivatives. |
| AID573784 | Antibacterial activity against Prevotella bivia by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID564228 | Activity of Escherichia coli TOP10 beta-lactamase OXA-143 | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID625445 | Antimicrobial activity against Bacillus subtilis MTCC 441 by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Iodine-catalyzed conjugate addition of indoles onto en-1,4-dione: a novel synthesis of 3-(1-(1H-indol-3-yl)-2-oxo-2-phenylethyl)indolin-2-ones as antibacterial and antifungal agents. |
| AID535765 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 08-041 expressing beta-lactamase TEM-1, MLST type ST-1584 and MAST type ST-1478 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID171268 | Concentration of compound in rat lung after intravenous injection of 20 mg/kg benzyl-penicillin after 40 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID565728 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group F clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID728909 | Antibacterial activity against levofloxacin-intermediate and levofloxacin-resistant Streptococcus pneumoniae after 18 hrs by microbroth dilution method | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5 | Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens. |
| AID1698705 | Antibacterial activity against genotype penicillin-resistant Streptococcus pneumoniae by CLSI method | 2020 | Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22 | Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. |
| AID573597 | Antibacterial activity against Fusobacterium necrophorum assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID322509 | AUC (0 to 12) in human very low birth weight preterm neonates at 14 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID368497 | Activity of Klebsiella oxytoca beta-lactamase K1assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID530505 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype II isolate 3776-04 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID1601841 | Antibacterial activity against Staphylococcus aureus CMCC(B) 26003 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID1546168 | Antimicrobial activity against Streptococcus pneumoniae | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID495735 | Kcat/Km ratio of Klebsiella pneumoniae Beta-lactamase TEM-26 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID559054 | Antibacterial activity against Streptococcus agalactiae by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID574949 | Antimicrobial activity against Streptococcus pneumoniae serotype 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID372613 | Activity of Escherichia coli DH5alpha beta-lactamase TEM-158 by microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID368548 | Activity of Pseudomonas aeruginosa MK-1184 AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID681168 | TP_TRANSPORTER: uptake in Oat3-expressing oocyte cells | 2004 | The Journal of pharmacology and experimental therapeutics, Jun, Volume: 309, Issue:3 | Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. |
| AID373055 | Antimicrobial activity against Escherichia coli BL21(DE3) by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID511442 | Antimicrobial activity against Streptococcus uberis ATCC 8749 harboring PBP2B N366I/T402I/V570A/P575S and PBP2X A492E mutation assessed as inhibition of visible growth by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID573591 | Antibacterial activity against Fusobacterium nucleatum by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID558645 | Antimicrobial activity against compound-intermediate Streptococcus pneumoniae by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID542626 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338G and PBP1a2349 mutant gene and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID511536 | Antimicrobial activity against Streptococcus uberis ATCC 9529 harboring PAP1A R273P, PBP2B N366I/T402I and PBP2X E381K/Q554E mutation after 28 passages assessed as inhibition of visible growth by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID565741 | Antimicrobial activity against erythromycin-susceptible Streptococcus agalactiae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1063962 | Antibacterial activity against Staphylococcus epidermidis H 6966/08 after 48 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID1347487 | Antibacterial activity against Staphylococcus epidermidis assessed as zone of inhibition after 24 to 48 hrs by well diffusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations. |
| AID533875 | Antibacterial activity against penicillin-nonsusceptible Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID519980 | Ratio of Kcat to Km for Klebsiella pneumoniae Beta-Lactamase SHV-55 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID573802 | Antibacterial activity against Prevotella melaninogenica assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID209571 | In vitro Minimum inhibitory concentration against Streptococcus faecium ATCC 8043-2 | 1981 | Journal of medicinal chemistry, Oct, Volume: 24, Issue:10 | Synthesis and evaluation of ureido- and vinylureidopenicillins as inhibitors of intraruminal lactic acid production. |
| AID543276 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID496403 | Antimicrobial activity against Borrelia burgdorferi N40 | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Ineffectiveness of tigecycline against persistent Borrelia burgdorferi. |
| AID529659 | Activity of Pseudomonas aeruginosa COL-1 beta-lactamase VIM-2 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID585175 | Activity of Beta-lactamase GES-1 E104, G170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID1870131 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4502/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID418553 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents. |
| AID573786 | Antibacterial activity against Prevotella melaninogenica by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID422493 | Antimicrobial activity against Carnobacterium divergens BM4490 expressing beta-lactamase CAD1 at 3 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID573118 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID511450 | Antimicrobial activity against Streptococcus uberis isolate BL246 harboring PBP2B N366I/T402I and PBP2X E381K/Q554E mutation assessed as inhibition of visible growth after 24 hrs by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID588111 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB G120K, A121D mutant gene, PBP1 L421P mutant gene, PBP2 XXXIV pattern, deletion of nucleotide A from mtrA promoter, MAST 225 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID1091741 | Antibacterial activity against Staphylococcus aureus MTCC 96 assessed as growth arrest at 37 degC for 24 hr | 2009 | Chemical & pharmaceutical bulletin, Jul, Volume: 57, Issue:7 | Synthesis, nematicidal and antimicrobial properties of Bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2H-pyrazolo[3,4-d]thiazol-5-yl]phenyl]methanes. |
| AID1765579 | Antibacterial activity against Klebsiella pneumoniae ATCC 700603 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID368547 | Activity of Pseudomonas aeruginosa MK-1184 AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID295095 | Antibacterial activity against Escherichia coli ATCC 11230 at 10 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID368308 | Ratio of Kcat to Km of Escherichia coli TEM1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID617969 | Antibacterial activity against Pseudomonas aeruginosa ATCC 13525 after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino) phenyl-N'-phenyl-thiourea. |
| AID279186 | Activity of Enterobacter cloacae S3 isolate beta lactamase LAP1 expressed in Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID573122 | Antibacterial activity against coagulase-negative and oxacillin-resistant Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID565730 | Antimicrobial activity against Streptococcus Group F clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID278674 | Antibacterial activity against Enterococcus faecalis isolate 5744 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID300057 | Antibacterial activity against Staphylococcus aureus ATCC 25923 at 10U by disc diffusion method | 2007 | Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15 | Synthesis, characterization and antimicrobial activity of new aliphatic sulfonamide. |
| AID375921 | Antibacterial activity against Bacteroides fragilis ATCC 23745 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents. |
| AID585186 | Ratio of Kcat to Km for Beta-lactamase GES-13 K104, N170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID556341 | Ratio of Kcat/Km for Salmonella enterica serotype Westhampton beta-lactamase CTX-M-53 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID558327 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P285 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID531460 | Antibacterial activity against Streptococcus pneumoniae serotype 33 assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID438303 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 5259 | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19 | Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening. |
| AID609855 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus BAA-44 assessed as growth inhibition after 18 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Unprecedented C-2 arylation of indole with diazonium salts: Syntheses of 2,3-disubstituted indoles and their antimicrobial activity. |
| AID278551 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium infantis ATCC 15697 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID561736 | Antibacterial activity against Beta-hemolytic Streptococcus group B assessed as susceptible isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID1180447 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus H 5996/08 after 24 hrs by microdilution method | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates. |
| AID209756 | Minimum inhibitory concentration against aerobic organism Streptococcus pyogenes strain 3124 | 1982 | Journal of medicinal chemistry, Apr, Volume: 25, Issue:4 | Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain. |
| AID562377 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus agalactiae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID483193 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 by microbroth dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID1437662 | Antibacterial activity against Streptococcus pyogenes ATCC 19615 after 20 to 24 hrs by two-fold microdilution method | |||
| AID573563 | Antibacterial activity against beta-lactamase producing Bacteroides vulgatus by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID534086 | Antibacterial activity against levofloxacin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID757812 | Antibacterial activity against Pseudomonas aeruginosa ATCC 13525 after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | Design, synthesis and antibacterial activity studies of thiazole derivatives as potent ecKAS III inhibitors. |
| AID561738 | Antibacterial activity against Beta-hemolytic Streptococcus group A assessed as resistant isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID324834 | Antimicrobial activity against Neisseria gonorrhoeae 119 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID522665 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis BA0018 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID1902630 | Antibacterial activity against Methicillin-drug resistant Staphylococcus aureus C0621 incubated for 18 hrs by by disc diffusion method | 2022 | ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2 | Antibacterial Activity of Metergoline Analogues: Revisiting the Ergot Alkaloid Scaffold for Antibiotic Discovery. |
| AID1428254 | Antibacterial activity against Pseudomonas aeruginosa RCMB 000103 assessed as zone of inhibition at 30 ug/ml | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold. |
| AID503223 | Antibacterial activity against penicillin-sensitive Streptococcus pneumoniae R6 by microscopy | 2007 | Nature chemical biology, Sep, Volume: 3, Issue:9 | Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. |
| AID556340 | Activity of Salmonella enterica serotype Westhampton beta-lactamase CTX-M-53 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID378411 | Antimicrobial activity against Yarrowia lipolytica HT20after 24 hrs | 2006 | Journal of natural products, Aug, Volume: 69, Issue:8 | Carneic acids A and B, chemotaxonomically significant antimicrobial agents from the xylariaceous ascomycete Hypoxylon carneum. |
| AID511440 | Antimicrobial activity against Streptococcus uberis ATCC 19436 harboring PAP1A A227T, PBP2B N366I/T402I and PBP2X E381K/D524A/Q554E mutation after 18 passages assessed as inhibition of visible growth by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID519997 | Antimicrobial activity against Streptococcus pneumoniae ribosomal mutant | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID519983 | Activity of Klebsiella pneumoniae Beta-Lactamase SHV-1 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID1437663 | Antibacterial activity against Streptococcus pneumoniae ATCC 6305 after 20 to 24 hrs by two-fold microdilution method | |||
| AID398237 | Antimicrobial activity against Bacillus subtilis 327 after 18 hrs by twofold serial microbroth dilution method | 2003 | Journal of natural products, Dec, Volume: 66, Issue:12 | A novel antibacterial iridoid and triterpene from Caiophora coronata. |
| AID340736 | Activity of Chryseobacterium indologenes metallo-beta-lactamase IND-5 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID573137 | Antibacterial activity against erythromycin-susceptible Streptococcus agalactiae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID665395 | Antibacterial activity against Bacillus subtilis MTCC 441 after 24 hrs by serial dilution technique | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Synthesis, characterization, antimicrobial activities and QSAR studies of some 10a-phenylbenzo[b]indeno[1,2-e][1,4]thiazin-11(10aH)-ones. |
| AID531571 | Antibacterial activity against Streptococcus constellatus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1402237 | Hemolytic activity in human erythrocytes at 10 to 200 ug/ml after 3 hrs relative to control | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Hetero-Diels-Alder reactions of novel 3-triazolyl-nitrosoalkenes as an approach to functionalized 1,2,3-triazoles with antibacterial profile. |
| AID1601853 | Antibacterial activity against multidrug-resistant Escherichia coli ATCC BAA-196 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID554673 | Antimicrobial activity against Streptococcus pneumoniae serotype 9V ST 156 harboring ERY-resistant erm(B) or mef(E) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID559708 | Antimicrobial activity against penicillin-resistant Staphylococcus epidermidis P1389 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID1366138 | Antibacterial activity against Staphylococcus aureus assessed as diameter of inhibition zone at 1 mg/ml | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22 | Antibacterial constituents of the plant family Amaryllidaceae. |
| AID495689 | Activity of Klebsiella oxytoca Beta-lactamase K1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID559520 | Antibacterial activity against Streptococcus mitis assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID586082 | Antimicrobial activity against multidrug-resistant Neisseria gonorrhoeae isolates harboring mosaic penicillin-binding protein 2 penA assessed as resistant isolates by disk susceptibility test | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characteristics and dissemination of mosaic penicillin-binding protein 2-harboring multidrug-resistant Neisseria gonorrhoeae isolates with reduced cephalosporin susceptibility in northern Taiwan. |
| AID490132 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents. |
| AID562359 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID535635 | Antimicrobial activity against Group B streptococcus serotype VI R5 harboring F395L, V405A, R433H, H438Y, and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID495736 | Kcat/Km ratio of Escherichia coli CMY-2 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID531576 | Antibacterial activity against Gemella morbillorum obtained from complicated skin and skin structure infections by RapID ANA system | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID368542 | Ratio of Kcat to Km of Pseudomonas aeruginosa 4352 AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1091749 | Antibacterial activity against Bacillus subtilis MTCC 441 assessed as inhibition zones at 100 ug/disk at 37 degC for 24 hr | 2009 | Chemical & pharmaceutical bulletin, Jul, Volume: 57, Issue:7 | Synthesis, nematicidal and antimicrobial properties of Bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2H-pyrazolo[3,4-d]thiazol-5-yl]phenyl]methanes. |
| AID573599 | Antibacterial activity against Fusobacterium nucleatum assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID559077 | Antibacterial activity against non-ciprofloxacin-susceptible Haemophilus influenzae by CLSI M7-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID399189 | Antibacterial activity against Staphylococcus aureus F7 at below 625 ug/mL after 24 hrs by broth microdilution method | 2004 | Journal of natural products, Jan, Volume: 67, Issue:1 | Africane-type sesquiterpenoids from the Argentine liverwort Porella swartziana and their antibacterial activity. |
| AID560497 | Activity of Escherichia coli MC4100 Beta-Lactamase CMY-30 harboring Val211?Gly211 mutation | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID532984 | Antibacterial activity against Escherichia coli MG1655 in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID1191517 | Antibacterial activity against Enterococcus sp. J 14365/08 after 24 hrs by broth microdilution method | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates. |
| AID524054 | Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID498369 | Antimicrobial activity against wild type streptomycin-susceptible Streptococcus gordonii harboring P438R mutation in ptsI assessed as bacterial count at 2 ug/ml after 24 hrs by macrodilution technique | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | A single mutation in enzyme I of the sugar phosphotransferase system confers penicillin tolerance to Streptococcus gordonii. |
| AID395347 | Antibacterial activity against Listeria monocytogenes ATCC 15313 at 10 units after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID171266 | Concentration of compound in rat lung after intravenous injection of 20 mg/kg benzyl-penicillin after 20 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID533931 | Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus NRS120 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID519996 | Antimicrobial activity against Streptococcus pneumoniae harboring mef(A) gene | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID587969 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 N104A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID661939 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 after 24 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11 | Synthesis and antimicrobial activities of structurally novel S,S'-bis(heterosubstituted) disulfides. |
| AID373215 | Activity of Bacillus cereus beta-lactamase BcI | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID171112 | Concentration of compound in rat blood after intravenous injection of 20 mg/kg benzyl-penicillin after 5 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID612540 | Binding affinity to human PepT2 in SKTP cells | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping. |
| AID324837 | Antimicrobial activity against Neisseria gonorrhoeae 201 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID341342 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 34 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID1243286 | Antimicrobial activity against Streptococcus pneumoniae ATCC 49619 by standard broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Synthesis and biological evaluation of levofloxacin core-based derivatives with potent antibacterial activity against resistant Gram-positive pathogens. |
| AID542618 | Antimicrobial activity against streptomycin-resistant Streptococcus pneumoniae R6 harboring PBP2x T338G and PBP1a2349 mutant gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID529326 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae serotype 15A URA5779 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID558611 | Antimicrobial activity against Streptococcus pneumoniae isolate 1564 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID573131 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID278680 | Antibacterial activity against Enterococcus faecium isolate 5751 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID521347 | Antimicrobial activity against Streptococcus pneumoniae isolate k-598 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID1063964 | Antibacterial activity against methicillin-resistant Staphylococcus aureus H 5996/08 after 48 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID565737 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus pyogenes clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID372615 | Activity of Escherichia coli DH5alpha beta-lactamase TEM-12 by microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID619675 | Antimicrobial activity against Salmonella paratyphi B CMCC 50094 by broth microdilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives. |
| AID442479 | Antibacterial activity against Staphylococcus epidermidis MTCC 435 by broth dilution method | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1 | Click chemistry: studies on the synthesis of novel fluorous tagged triazol-4-yl substituted quinazoline derivatives and their biological evaluation--theoretical and experimental validation. |
| AID508372 | Antibacterial activity against Streptococcus pneumoniae harboring erm(B) and mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID558631 | Antimicrobial activity against Streptococcus pneumoniae isolate 4755 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1659472 | Antimicrobial activity against Escherichia coli ATCC 25922 assessed as induction of changes in mass spectral profile of bacteria 1 times MIC uM by MALDI-TOF MS analysis | 2020 | Journal of medicinal chemistry, 08-27, Volume: 63, Issue:16 | Machine Learning in Mass Spectrometry: A MALDI-TOF MS Approach to Phenotypic Antibacterial Screening. |
| AID524061 | Binding affinity to methicillin-, vancomycin-susceptible Staphylococcus aureus ATCC 29213 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID528723 | Antibacterial activity against Streptococcus constellatus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID543278 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x and Streptococcus pneumoniae 72521 pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID520726 | Activity of Escherichia coli TOP10 beta-lactamase OXA-58 assessed per mg of protein at 100 uM | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID495717 | Activity of Klebsiella pneumoniae SHV-1 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID532675 | Antimicrobial activity against ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal. |
| AID573595 | Antibacterial activity against Fusobacterium nucleatum assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1601852 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID554864 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F ST 271 harboring ERY-resistant erm(B) and mef(E) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID524972 | Antibacterial activity against Streptococcus pyogenes clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID535353 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as susceptible isolates by by based on parenterally dosed broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID1193568 | Antibacterial activity against Enterococcus faecalis ATCC 14506 at 100 ug after 24 hrs | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. |
| AID451354 | Antimicrobial activity against Salmonella enteritidis OPS10 after 24 hrs by broth dilution method | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. |
| AID1076539 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity. |
| AID322500 | Clearance in human very low birth weight preterm neonates at 28 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID573801 | Antibacterial activity against Prevotella intermedia assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1287893 | Antimicrobial activity against Klebsiella aerogenes MTCC 39 after 24 hrs by serial two-fold broth dilution method | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline-thiazolidine-based hybrids. |
| AID781325 | pKa (acid-base dissociation constant) as determined by Liao ref: J Chem Info Model 2009 | 2014 | Pharmaceutical research, Apr, Volume: 31, Issue:4 | Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. |
| AID519632 | Activity of beta-lactamase FUS1 assessed as compound hydrolysis by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID524638 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea assessed as incidence of susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID508370 | Antibacterial activity against Streptococcus pneumoniae harboring mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID580180 | Antimicrobial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5 | Synthesis, structure, molecular docking, and structure-activity relationship analysis of enamines: 3-aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials. |
| AID533928 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus 1652 harboring U2500A mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID373052 | Antimicrobial activity against Escherichia coli DH10B carrying pJIM2246 expressing Bacillus clausii NR beta-lactamase BCL1 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID531453 | Antibacterial activity against Streptococcus pneumoniae serotype 19A assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1309202 | Antibacterial activity against Pseudomonas lachrymans by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Four new minor brominated indole related alkaloids with antibacterial activities from Laurencia similis. |
| AID567279 | Activity of Acinetobacter baumannii ADC-33 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID1128827 | Antibacterial activity against Bacillus subtilis SCSIO BS01 after 18 hrs by broth microdilution method | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Spiromastixones A-O, antibacterial chlorodepsidones from a deep-sea-derived Spiromastix sp. fungus. |
| AID425335 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. |
| AID559513 | Antibacterial activity against levofloxacin susceptible Streptococcus pneumoniae assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID565732 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group G clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID524066 | Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID278538 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium breve R0070 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID611680 | Antifungal activity against Septoria tritici at 0.05 mg by agar diffusion method | 2011 | Journal of natural products, Jul-22, Volume: 74, Issue:7 | Bioactive 11,20-epoxy-3,5(16)-diene briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. |
| AID1245114 | Antimicrobial activity against Bacillus subtilis ATCC 6633 after 18 hrs by broth microdilution method | 2015 | Bioorganic & medicinal chemistry, Sep-15, Volume: 23, Issue:18 | Design, synthesis and molecular docking of salicylic acid derivatives containing metronidazole as a new class of antimicrobial agents. |
| AID1882851 | Binding affinity to Staphylococcus aureus ATCC 43300 50S ribosomal subunit assessed as equilibrium dissociation constant by surface plasmon resonance analysis | |||
| AID278526 | Antimicrobial activity against Bifidobacterium infantis ATCC 15697 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID29160 | Dissociation constant of the compound | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. Synthesis and properties of some dihydropyridine and dihydroiosquinoline derivatives of benzylpenicillin. |
| AID522648 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis Africa 33 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID205978 | In Vitro minimal inhibitory concentration against Staphylococcus aureus (FDA 209P) | 1998 | Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24 | Syntheses of new isodethiaazacephems as potent antibacterial agents. |
| AID1191518 | Antibacterial activity against Enterococcus sp. J 14365/08 after 48 hrs by broth microdilution method | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates. |
| AID559056 | Antibacterial activity against Lancefield Streptococcus sp. group F by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID770973 | Antibacterial activity against Staphylococcus aureus MTCC 96 by broth dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Demonic axe-like conjugated alkynes in combating microbes. |
| AID520728 | Activity of Acinetobacter baumannii CIP7010 beta-lactamase assessed per mg of protein at 100 uM | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID573785 | Antibacterial activity against Prevotella intermedia by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID508367 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID528724 | Antibacterial activity against Streptococcus oralis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID529655 | Activity of Pseudomonas aeruginosa 9551 beta-lactamase VIM-15 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID571175 | Antibacterial activity against Neisseria gonorrhoeae assessed as susceptible isolates by disk agar diffusion method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID495697 | Activity of Pseudomonas aeruginosa VIM-2 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID573825 | Antibacterial activity against beta-lactamase producing Clostridium tertium by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID508378 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae harboring mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID532983 | Antibacterial activity against Escherichia coli W3110 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID1279009 | Antibacterial activity against methicillin-resistant Staphylococcus aureus H 5996/08 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID558537 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter coli isolate P321 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID1237617 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC510019 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID508373 | Antibacterial activity against Streptococcus pneumoniae harboring mutation in L4 ribosomal protein after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID524648 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA, penB, ponA and mtrR mutant gene assessed as incidence of susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID171115 | Concentration of compound in rat brain after intravenous injection of 20 mg/kg benzyl-penicillin after 10 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID534088 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID524257 | Ratio of Kcat to Km in Escherichia coli beta-lactamase SHV-1 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID1254301 | Antibacterial activity against methicillin-resistant Staphylococcus aureus H 5996/08 after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID486256 | Antibacterial activity against Staphylococcus aureus NCIM 2120 after 24 hrs by disc diffusion method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Synthesis and biological evaluation of beta-chloro vinyl chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity. |
| AID574948 | Antimicrobial activity against Streptococcus pneumoniae serotype 19A by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1546647 | Antibacterial activity against Staphylococcus epidermidis assessed as reduction in microbial growth after 24 hrs by CLSI based microdilution method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1 | Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents. |
| AID245519 | Minimum inhibitory concentration against Chromobacterium violaceum (Gram-negative) was determined by broth dilution method | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of 2,4,6-tri substituted s-triazines. |
| AID542615 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338G mutant gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID524043 | Antibacterial activity against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID508375 | Antibacterial activity against quinolone-susceptible Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID356754 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 310 after 18 hrs by microbroth dilution method | 2001 | Journal of natural products, Jul, Volume: 64, Issue:7 | Biological and mechanistic activities of xanthorrizol and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol isolated from Iostephane heterophylla. |
| AID559060 | Antibacterial activity against Streptococcus pyogenes by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID1112105 | Antialgal activity against 'Chlorella' fusca by agar diffusion test | 2012 | Fitoterapia, Apr, Volume: 83, Issue:3 | Pyrenocines J-M: four new pyrenocines from the endophytic fungus, Phomopsis sp. |
| AID524047 | Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID373050 | Antimicrobial activity against Bacillus clausii NR expressing beta-lactamase BCL1 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID351193 | Clearance in iv dosed neonates with gestational age of 27 to 40 weeks | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks. |
| AID558620 | Antimicrobial activity against Streptococcus pneumoniae isolate 3282 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID524875 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA and penB mutant gene assessed as incidence of resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID171261 | Concentration of compound in rat liver after intravenous injection of 20 mg/kg benzyl-penicillin after 40 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID520397 | Antibacterial activity against erm(B) and mef(E)-positive Streptococcus pneumoniae isolate Spain 6B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID1072989 | Antimicrobial activity against Staphylococcus aureus Smith MB 2865 after 20 hrs by 2-fold serial broth dilution method | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Isolation, structure elucidation, and biological activity of altersolanol P using Staphylococcus aureus fitness test based genome-wide screening. |
| AID679535 | TP_TRANSPORTER: inhibition of Ochratoxin A uptake (OTA: 1 uM, PCG: 200 uM) in OAT1-expressing S2 cells | 2001 | Life sciences, Sep-21, Volume: 69, Issue:18 | Characterization of ochratoxin A transport by human organic anion transporters. |
| AID1072991 | Antibacterial activity against Streptococcus mutans ATCC 35668 after 24 hrs by microbroth dilution assay | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Pyrano-isoflavans from Glycyrrhiza uralensis with antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis. |
| AID625284 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID70750 | In Vitro minimal inhibitory concentration against Escherichia coli (ATCC 39188) | 1998 | Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24 | Syntheses of new isodethiaazacephems as potent antibacterial agents. |
| AID498377 | Antimicrobial activity against penicillin- and streptomycin-resistant Streptococcus gordonii Tol1 harboring Tol1 mutation infected in Wistar rat assessed as protection against bacterial infection at 300000 U/kg, sc administered 16 hrs after infection ever | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | A single mutation in enzyme I of the sugar phosphotransferase system confers penicillin tolerance to Streptococcus gordonii. |
| AID573141 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus agalactiae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID372895 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Apr, Volume: 44, Issue:4 | Synthesis, characterization and structure-activity relationship analysis of novel depsides as potential antibacterials. |
| AID341521 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 29 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID524663 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing mtrR mutant gene assessed as percentage intermediate isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID529899 | Antimicrobial activity against Leptospira weilii isolate 8 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID322507 | Volume of distribution at steady state in human adults at 600 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID520396 | Antibacterial activity against mef(E) and mef(A)-positive Streptococcus pneumoniae isolate CC-6B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID529898 | Antimicrobial activity against Leptospira weilii isolate 6 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID561734 | Antibacterial activity against Beta-hemolytic Streptococcus group B assessed as resistant isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID573120 | Antibacterial activity against coagulase-negative and oxacillin-susceptible Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID654972 | Competitive inhibition of pig PAP using para-nitrophenol as substrate at pH 4.9 preincubated for 10 mins by UV-visible spectrophotometry | 2012 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7 | Penicillin inhibitors of purple acid phosphatase. |
| AID658946 | Antibacterial activity against Escherichia coli 124300 at 100 mg/ml after 24 hrs by agar-well diffusion technique | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | 2-Aminothiophenes as building blocks in heterocyclic synthesis: synthesis and antimicrobial evaluation of a new class of pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and pyridin-2-one derivatives. |
| AID654973 | Uncompetitive inhibition of pig PAP using para-nitrophenol as substrate at pH 4.9 preincubated for 10 mins by UV-visible spectrophotometry | 2012 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7 | Penicillin inhibitors of purple acid phosphatase. |
| AID533941 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis 412 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID1348082 | Antimicrobial activity against Candida tropicalis ATCC 13803 assessed as zone of inhibition at 50 ug per disc after 48 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID210030 | Antibacterial activity was determined against clinically isolated penicillin resistant Streptococcus pneumoniae (PRSP) strains (50 strains); Range= 1-4 | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6 | Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents. |
| AID554867 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F ST 3245 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID1079941 | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | |||
| AID573119 | Antibacterial activity against coagulase-negative and oxacillin-susceptible Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID520412 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID490134 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents. |
| AID1209731 | Drug uptake by mouse OAT3 expressed in CHO cells at 100 uM after 25 mins by HPLC/UV detection method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4 | Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. |
| AID1128826 | Antibacterial activity against Bacillus thuringiensis SCSIO BT01 after 18 hrs by broth microdilution method | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Spiromastixones A-O, antibacterial chlorodepsidones from a deep-sea-derived Spiromastix sp. fungus. |
| AID520393 | Antibacterial activity against mef-positive Streptococcus pneumoniae isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID1149038 | Antibacterial activity against Salmonella schottmuelleri assessed as growth inhibition incubated for 24 hrs using acid chloride | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 | Beta-lactam antibiotics with N-oxide side chains. 1. Quinoxaline N-oxides. |
| AID562361 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1091746 | Antibacterial activity against Pseudomonas aeruginosa MTCC 741 assessed as inhibition zones at 100 ug/disk at 37 degC for 24 hr | 2009 | Chemical & pharmaceutical bulletin, Jul, Volume: 57, Issue:7 | Synthesis, nematicidal and antimicrobial properties of Bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2H-pyrazolo[3,4-d]thiazol-5-yl]phenyl]methanes. |
| AID322493 | Cmax in human very low birth weight preterm neonates at 14 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID529895 | Antimicrobial activity against Leptospira interrogans serovar Icterohaemorrhagiae isolate 3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID351188 | Volume of distribution in central compartment in preterm neonates with septicemia or invasive infections with gestational age of less than 32 weeks at 50000 U/kg, iv administered every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks. |
| AID562583 | Antimicrobial activity against Streptococcus pyogenes clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1161139 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID467612 | Fraction unbound in human plasma | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. |
| AID557269 | Antimicrobial activity against Streptococcus pneumoniae 1394 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID591663 | Antimicrobial activity against multidrug-resistant Streptococcus pneumoniae after 18 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7 | A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold. Synthesis and antibacterial properties. |
| AID558627 | Antimicrobial activity against Streptococcus pneumoniae isolate 3587 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID557469 | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae 3009 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID563976 | Activity of Klebsiella pneumoniae 05-560 beta-lactamase VIM2 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID1079939 | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | |||
| AID1565590 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by CLSI based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity. |
| AID1091739 | Antibacterial activity against Enterobacter aerogenes MTCC 39 assessed as growth arrest at 37 degC for 24 hr | 2009 | Chemical & pharmaceutical bulletin, Jul, Volume: 57, Issue:7 | Synthesis, nematicidal and antimicrobial properties of Bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2H-pyrazolo[3,4-d]thiazol-5-yl]phenyl]methanes. |
| AID200682 | In Vitro minimal inhibitory concentration against Salmonella typhi (O-901) | 1998 | Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24 | Syntheses of new isodethiaazacephems as potent antibacterial agents. |
| AID571185 | Antibacterial activity against Neisseria gonorrhoeae harboring KD gene by disk agar diffusion method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID1126515 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry, Apr-15, Volume: 22, Issue:8 | Synthesis, molecular docking and biological evaluation of metronidazole derivatives containing piperazine skeleton as potential antibacterial agents. |
| AID666595 | Antibacterial activity against Escherichia coli after 16 hrs by broth dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Facile synthesis, cytotoxic and antimicrobial activity studies of a new group of 6-aryl-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines. |
| AID554871 | Antimicrobial activity against Streptococcus pneumoniae serotype 6B ST 90 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID573574 | Antibacterial activity against beta-lactamase producing Bacteroides uniformis assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID503226 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 38030509 by microscopy | 2007 | Nature chemical biology, Sep, Volume: 3, Issue:9 | Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. |
| AID573590 | Antibacterial activity against Fusobacterium varium by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID521348 | Antimicrobial activity against Streptococcus pneumoniae isolate 187 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID575079 | Antimicrobial activity against Streptococcus pneumoniae serotype 7F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID573824 | Antibacterial activity against beta-lactamase producing Clostridium septicum by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1191513 | Antibacterial activity against methicillin-resistant Staphylococcus aureus H 5996/08 after 24 hrs by broth microdilution method | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates. |
| AID1254305 | Antibacterial activity against Enterococcus sp. J 14365/08 after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID522649 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis Colorado by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID524689 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID591665 | Antimicrobial activity against multidrug-resistant Moraxella catarrhalis after 18 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7 | A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold. Synthesis and antibacterial properties. |
| AID524256 | Activity at Escherichia coli beta-lactamase SHV-1 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID522668 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis B126 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID519747 | Activity of Klebsiella pneumoniae Beta-Lactamase SHV-72 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID1191515 | Antibacterial activity against Staphylococcus epidermidis H 6966/08 after 24 hrs by broth microdilution method | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates. |
| AID508376 | Antibacterial activity against quinolone-resistant Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID587967 | Activity of Escherichia coli beta-lactamase Toho-1 G232A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID1129598 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Apr-09, Volume: 76 | Design, synthesis and molecular modeling of pyrazole-quinoline-pyridine hybrids as a new class of antimicrobial and anticancer agents. |
| AID1601849 | Antibacterial activity against Pseudomonas aeruginosa CMCC 27853 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID425339 | Antibacterial activity against azithromycin-resistant Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. |
| AID451350 | Antimicrobial activity against Staphylococcus aureus NBRC13276 after 24 hrs by broth dilution method | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. |
| AID559706 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus P1374 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID577451 | Antimicrobial activity against penicillin intermediate resistant Streptococcus pneumoniae isolate 8009 harboring PBP2b 443SSNA mutant by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID335495 | Antimicrobial activity against Staphylococcus aureus 375 after 18 to 20 hrs by standard broth microdilution method | 2002 | Journal of natural products, Jun, Volume: 65, Issue:6 | New antimicrobial cycloartane triterpenes from Acalypha communis. |
| AID395340 | Antibacterial activity against Escherichia coli ATCC 11230 at 10 units after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID1149036 | Antibacterial activity against Staphylococcus aureus assessed as growth inhibition incubated for 24 hrs using acid chloride | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 | Beta-lactam antibiotics with N-oxide side chains. 1. Quinoxaline N-oxides. |
| AID573797 | Antibacterial activity against Prevotella intermedia assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID573115 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1237616 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC515992 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID368545 | Ratio of Kcat to Km of Pseudomonas aeruginosa 18SH AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID559522 | Antibacterial activity against Streptococcus salivarius assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID495662 | Ratio of Kcat to Km for Pseudomonas aeruginosa 531 beta-lactamase BEL-2 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID574950 | Antimicrobial activity against Streptococcus pneumoniae serotype 35B by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID559044 | Antibacterial activity against Listeria monocytogenes by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID522645 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis Texas by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID619775 | Antibacterial activity against Escherichia coli RCMB 000103 at 30 mg/ml after 24 hrs by agar well diffusion method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Design and synthesis of some new thiophene, thienopyrimidine and thienothiadiazine derivatives of antipyrine as potential antimicrobial agents. |
| AID569260 | Antimicrobial activity against Staphylococcus aureus | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. |
| AID582967 | Antimicrobial activity against beta-lactamase B-deficient Yersinia enterocolitica GY5542 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID587966 | Activity of Escherichia coli beta-lactamase Toho-1 F160T mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID368493 | Activity of Escherichia coli CTX-M-15 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID322488 | Half life in human very low birth weight preterm neonates at 28 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID1237614 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC51033 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID531455 | Antibacterial activity against Streptococcus pneumoniae serotype 3 assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID530504 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype IB isolate 5436-03 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID373054 | Antimicrobial activity against Escherichia coli BL21(DE3) carrying pET9a expressing Bacillus clausii beta-lactamase BCL1 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID431315 | Antibacterial activity against Bacillus cereus ATCC 11778 | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis and structure-activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents. |
| AID1079942 | Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] | |||
| AID368314 | Activity of Staphylococcus aureus betalactamase PC1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID561099 | Antibacterial activity against Pasteurella multocida ATCC 43137 by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID1072982 | Antimicrobial activity against Haemophilus influenzae MB 4572 after 20 hrs by 2-fold serial broth dilution method | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Isolation, structure elucidation, and biological activity of altersolanol P using Staphylococcus aureus fitness test based genome-wide screening. |
| AID522667 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis K8091 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID378410 | Antimicrobial activity against Bacillus subtilis ATCC 6633 after 18 hrs | 2006 | Journal of natural products, Aug, Volume: 69, Issue:8 | Carneic acids A and B, chemotaxonomically significant antimicrobial agents from the xylariaceous ascomycete Hypoxylon carneum. |
| AID559067 | Antibacterial activity against Streptococcus salivarius by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | |||
| AID278521 | Antimicrobial activity against Bifidobacterium animalis ATCC 27536 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID368723 | Ratio of Kcat to Km of Pseudomonas aeruginosa MK-1184 AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID425341 | Antibacterial activity against quinolone-resistant Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. |
| AID577453 | Inhibition of Bocillin FL binding to Streptococcus pneumoniae isolate 8865 PBP2b | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID171258 | Concentration of compound in rat liver after intravenous injection of 20 mg/kg benzyl-penicillin after 10 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID574041 | Antibacterial activity against beta-lactamase producing Peptoniphilus asaccharolyticus by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID522662 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis K7038 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID569346 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID573593 | Antibacterial activity against Fusobacterium necrophorum by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID520388 | Ratio of Kcat to Km for Pseudomonas aeruginosa COL-1 metallo-beta lactamase VIM-2 | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID533878 | Antibacterial activity against amoxicillin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID511449 | Antimicrobial activity against Streptococcus uberis isolate ALP 8144 harboring PBP2X E381K/Q554E mutation assessed as inhibition of visible growth after 24 hrs by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID529657 | Activity of Pseudomonas aeruginosa 166301 beta-lactamase VIM-16 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID511532 | Antimicrobial activity against Streptococcus uberis isolate 20568 harboring PAP1A G386R, PBP2B N366I/T402I/V570A/P575S and PBP2X E381K/Q554E mutation assessed as inhibition of visible growth after 24 hrs by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID425393 | Antibacterial activity against mucosa-associated Escherichia coli isolates isolated from patients with Crohn's disease by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics. |
| AID531570 | Antibacterial activity against Streptococcus sp. 'group G' obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID278677 | Antibacterial activity against Enterococcus faecium isolate 2547 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID493655 | Antimicrobial activity against Streptococcus faecalis ATCC 9790 by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors. |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | |||
| AID1091743 | Antibacterial activity against Bacillus subtilis MTCC 441 assessed as growth arrest at 37 degC for 24 hr | 2009 | Chemical & pharmaceutical bulletin, Jul, Volume: 57, Issue:7 | Synthesis, nematicidal and antimicrobial properties of Bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2H-pyrazolo[3,4-d]thiazol-5-yl]phenyl]methanes. |
| AID524981 | Antibacterial activity against Streptococcus oralis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID418563 | Antibacterial activity against Bacteroides fragilis ATCC 23745 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents. |
| AID525546 | Antimicrobial activity against Haemophilus influenzae Rd KW20 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID529321 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae serotype 6B URA4566 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID531604 | Activity of Escherichia coli Inhibitor-resistant beta-lactamase SHV-56 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID619681 | Antifungal activity against Candida albicans ATCC 10231 by broth microdilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives. |
| AID573114 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID574023 | Antibacterial activity against beta-lactamase producing Peptostreptococcus anaerobius by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID508295 | Inhibition of PBP1 in penicillin-resistant Enterococcus faecium D63r membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID524977 | Antibacterial activity against Streptococcus bovis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID1112107 | Antimicrobial activity against Bacillus megaterium by agar diffusion test | 2012 | Fitoterapia, Apr, Volume: 83, Issue:3 | Pyrenocines J-M: four new pyrenocines from the endophytic fungus, Phomopsis sp. |
| AID562372 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group C clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID546428 | Activity at Pseudomonas aeruginosa PDC-3 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID528725 | Antibacterial activity against Streptococcus intermedius clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID372899 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Apr, Volume: 44, Issue:4 | Synthesis, characterization and structure-activity relationship analysis of novel depsides as potential antibacterials. |
| AID498374 | Antimicrobial activity against wild type streptomycin-susceptible Streptococcus gordonii harboring P438R mutation in ptsI assessed as decrease in [14C]glucose uptake at 2 ug/ml after 60 mins by liquid scintillation counting | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | A single mutation in enzyme I of the sugar phosphotransferase system confers penicillin tolerance to Streptococcus gordonii. |
| AID591664 | Antimicrobial activity against multidrug-resistant Haemophilus influenzae after 18 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7 | A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold. Synthesis and antibacterial properties. |
| AID293929 | Inhibition of cell wall biosynthesis in Staphylococcus aureus assessed as cytoplasmic membrane rupture | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6 | N-thiolated beta-lactams: Studies on the mode of action and identification of a primary cellular target in Staphylococcus aureus. |
| AID573552 | Antibacterial activity against Bacteroides fragilis assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID585179 | Activity of Beta-lactamase GES-6 K104, S170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID557209 | Antibacterial activity against Beta-lactamase-negative Neisseria meningitidis assessed as percent susceptible isolates by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. |
| AID573143 | Antibacterial activity against penicillin-susceptible Streptococcus viridans by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID508365 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID522391 | Inhibition of Aeromonas enteropelogenes Beta-lactamase TRU1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID563972 | Activity of Klebsiella pneumoniae 05-560 beta-lactamase NDM-1 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID562606 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID493653 | Antimicrobial activity against Bacillus subtilis ATCC 6633 by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors. |
| AID535763 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 06-041 expressing beta-lactamase TEM-1, MLST type ST-1588 and MAST type ST-4012 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID546427 | Activity at Pseudomonas aeruginosa PDC-2 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID554858 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 2306 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID557495 | Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID565739 | Antimicrobial activity against Streptococcus pyogenes clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID381180 | Antibacterial activity against Staphylococcus aureus after 24 to 72 hrs by disk diffusion method | 1999 | Journal of natural products, Sep, Volume: 62, Issue:9 | Antimicrobial and antitumor activities of mycosporulone. |
| AID395341 | Antibacterial activity against Staphylococcus aureus ATCC 6538 at 10 units after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID565738 | Antimicrobial activity against erythromycin-susceptible Streptococcus pyogenes clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | |||
| AID542627 | Antimicrobial activity against streptomycin-resistant Streptococcus pneumoniae R6 harboring PBP2x T338G and PBP1a2349 mutant gene and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID681415 | TP_TRANSPORTER: inhibition of Homovanillic acid uptake (HVA: 0.2 uM, PCG: 1000 uM) in Xenopus laevis oocytes | 2003 | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Apr, Volume: 23, Issue:4 | Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. |
| AID573155 | Antibacterial activity against vancomycin-resistant Enterococcus faecium by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID520404 | Antimicrobial activity against macrolide-resistant Streptococcus pneumoniae by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID520405 | Antimicrobial activity against quinolone-susceptible Streptococcus pneumoniae by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID1647683 | Antibacterial activity against Staphylococcus epidermidis ATCC 14990 assessed as reduction in microbial growth after 24 hrs by agar well diffusion assay | 2020 | Journal of natural products, 02-28, Volume: 83, Issue:2 | Isolation, Identification, and Decomposition of Antibacterial Dialkylresorcinols from a Chinese |
| AID373209 | Activity of Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID573146 | Antibacterial activity against penicillin-nonsusceptible Streptococcus viridans by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID336568 | Antibacterial activity against Streptococcus mutans ATCC 25175 after 2 days by twofold serial dilution method | 1992 | Journal of natural products, Oct, Volume: 55, Issue:10 | Antibacterial activity of totarol and its potentiation. |
| AID557506 | Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID374681 | Antimicrobial activity against kanamycin-resistant Escherichia coli K-12 M1 W3110 deltarapA mutant flow cell-generated 24 hrs biofilms at 350 ug/ml after 1 hr using BacLight staining by CSLM | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID508379 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae harboring erm(B) and mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID559068 | Antibacterial activity against Streptococcus sanguinis by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID334154 | Antimicrobial activity against Staphylococcus aureus at 10 units by antimicrobial disk assay | 1997 | Journal of natural products, Nov, Volume: 60, Issue:11 | New phomopsolides from a Penicillium sp. |
| AID486251 | Cytotoxicity against human CCK8 cells at 10 uM | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Synthesis and biological evaluation of beta-chloro vinyl chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity. |
| AID495721 | Activity of Escherichia coli CMY-2 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID278561 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium breve ATCC 15700 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID341527 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 42 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID534396 | Ratio of Kcat to Km for Escherichia coli JM109 harboring recombinant pKHM-1 Beta-lactamase KHM-1 assessed as compound hydrolysis by UV-visible spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate. |
| AID559065 | Antibacterial activity against Streptococcus mitis by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID374685 | Antimicrobial activity against kanamycin-resistant Escherichia coli K-12 M2 W3110 deltayhcQ mutant 24 hrs biolflim at 350 ug/ml after 1 hr using BacLight staining | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID1546648 | Antibacterial activity against Bacillus subtilis MTCC 441 assessed as reduction in microbial growth after 24 hrs by CLSI based microdilution method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1 | Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents. |
| AID575944 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. |
| AID585185 | Ratio of Kcat to Km for Beta-lactamase GES-6 K104, S170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID394488 | Activity of Hafnia alvei beta-lactamase ACC-1 assessed as nmol of compound hydrolysis per ug of protein | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID557504 | Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1638895 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 measured after 18 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action. |
| AID532987 | Antibacterial activity against Pseudomonas aeruginosa NCIM 5029 in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID287375 | Antibacterial activity against Micrococcus luteus after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID1091748 | Antibacterial activity against Lysinibacillus sphaericus MTCC 11 assessed as inhibition zones at 100 ug/disk at 37 degC for 24 hr | 2009 | Chemical & pharmaceutical bulletin, Jul, Volume: 57, Issue:7 | Synthesis, nematicidal and antimicrobial properties of Bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2H-pyrazolo[3,4-d]thiazol-5-yl]phenyl]methanes. |
| AID398235 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus 375 after 18 hrs by twofold serial microbroth dilution method | 2003 | Journal of natural products, Dec, Volume: 66, Issue:12 | A novel antibacterial iridoid and triterpene from Caiophora coronata. |
| AID322489 | Half life in human very low birth weight preterm neonates at 14.3 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID1601843 | Antibacterial activity against Streptococcus pyogenes CMCC 32067 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID1279017 | Antibacterial activity against Klebsiella pneumoniae D 11750/08 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID557512 | Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID351187 | Clearance in preterm neonates with septicemia or invasive infections with gestational age of less than 32 weeks at 50000 U/kg, iv administered every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks. |
| AID530339 | Activity of Pseudomonas aeruginosa VIM-13 beta-lactamase | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID1546640 | Antibacterial activity against Staphylococcus aureus MTCC 96 assessed as diameter of zone of inhibition at 200 ug/ml after 24 hrs by agar well diffusion method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1 | Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents. |
| AID522389 | Activity of Aeromonas caviae Beta-lactamase CAV1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID373051 | Antimicrobial activity against Bacillus clausii ATCC 21537 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID531423 | Antibacterial activity against Streptococcus pneumoniae serotype 15A by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID437460 | Antimicrobial activity Staphylococcus aureus ATCC 6538 by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors. |
| AID524640 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing mtrR mutant gene assessed as incidence of susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID524246 | Antimicrobial activity against Escherichia coli DH5alpha expressing SHV-84 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID558329 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P305 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID1638898 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 measured after 18 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action. |
| AID522656 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis 17T5 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID574032 | Antibacterial activity against beta-lactamase producing Micromonas micros by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID74714 | Inhibition of gram positive bacteria growth. | 1989 | Journal of medicinal chemistry, Jun, Volume: 32, Issue:6 | Synthesis and antimicrobial properties of substituted beta-aminoxypropionyl penicillins and cephalosporins. |
| AID398236 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 310 after 18 hrs by twofold serial microbroth dilution method | 2003 | Journal of natural products, Dec, Volume: 66, Issue:12 | A novel antibacterial iridoid and triterpene from Caiophora coronata. |
| AID529893 | Antimicrobial activity against Leptospira interrogans serovar Bataviae isolate 1 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID534084 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID543280 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp2b and Streptococcus pneumoniae 3191 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID1546644 | Antibacterial activity against Pseudomonas aeruginosa MTCC 741 assessed as diameter of zone of inhibition at 200 ug/ml after 24 hrs by agar well diffusion method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1 | Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents. |
| AID1449628 | Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-taurocholate transport into vesicles incubated for 5 mins by Topcount based rapid filtration method | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12 | Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. |
| AID531572 | Antibacterial activity against Streptococcus mitis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID573121 | Antibacterial activity against coagulase-negative and oxacillin-susceptible Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID524980 | Antibacterial activity against Streptococcus mitis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID529334 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae serotype 14 URA4203 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID428134 | Antimicrobial activity against penicillin-resistant Streptococcus gordonii PR1_2 mutant assessed as logarithmic reduction in viability at stationary phase of growth after 70 hrs | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory. |
| AID438297 | Inhibition of penicillin-sensitive Streptococcus pneumoniae R6 PBP2X preincubated for 1 hr before addition of substrate (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19 | Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening. |
| AID530519 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype V isolate 5677-04 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID486727 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Synthesis, structure and structure-activity relationship analysis of caffeic acid amides as potential antimicrobials. |
| AID1237609 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC43300 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID525547 | Antimicrobial activity against ampicillin resistant nontypeable Haemophilus influenzae isolate BB1050 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID531579 | Antibacterial activity against Micrococcus spp. obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID565731 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group G clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID368546 | Ratio of Kcat to Km of Pseudomonas aeruginosa 18SH AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1870120 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4883/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID1348089 | Antimicrobial activity against Bacillus subtilis subsp. subtilis ATCC 6051 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID559710 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus P1386 at 500 ug/ml after 9 hrs by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID565729 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group F clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID285267 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM29 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID341528 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 14 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID508304 | Inhibition of PBP3 in wild type Enterococcus faecium D63 membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID559532 | Antibacterial activity against non-ciprofloxacin-susceptible Haemophilus influenzae assessed as percent susceptible isolates by CLSI M7-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID524031 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 1564 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID530340 | Activity of Pseudomonas aeruginosa VIM-1 beta-lactamase | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID368498 | Activity of Enterobacter cloacae 4092 AmpC (E2) assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID295119 | Antibacterial activity against Micrococcus luteus La 2971 at 10 ug by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID524976 | Antibacterial activity against Streptococcus sp. Group G clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID569340 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID1852760 | Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 assessed as bacterial growth inhibition by broth microdilution assay | 2022 | RSC medicinal chemistry, Sep-21, Volume: 13, Issue:9 | Design and evaluation of poly-nitrogenous adjuvants capable of potentiating antibiotics in Gram-negative bacteria. |
| AID307354 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by broth dilution assay | 2007 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 17, Issue:12 | Penicillin-bound polyacrylate nanoparticles: restoring the activity of beta-lactam antibiotics against MRSA. |
| AID508294 | Antimicrobial activity against Enterococcus faecium D63 assessed as bacterial killing at 4 times MIC by time kill curve method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID558319 | Antibacterial activity against Campylobacter coli by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID535632 | Antimicrobial activity against Group B streptococcus R8 harboring T77I, S353F and A514V in PBP 2X; V80A and G613R in PBP 2B; and L45P, N163K, N723S and G527V in PBP 1A by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID524258 | Activity at Escherichia coli beta-lactamase SHV-84 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID519981 | Ratio of Kcat to Km for Klebsiella pneumoniae Beta-Lactamase SHV-1 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID530518 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype V isolate 4857-03 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID574955 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19F by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID554862 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F ST 671 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID522650 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis K7978 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID565740 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus agalactiae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID495691 | Activity of Escherichia coli CMY-2 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID531314 | Ratio of Kcat to Km for Pseudomonas aeruginosa beta-lactamase VIM-7 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID322492 | Cmax in human very low birth weight preterm neonates at 28 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID322490 | Half life in human term neonates at 15 mg/kg, im administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID575081 | Antimicrobial activity against Streptococcus pneumoniae serotype 6C assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID495661 | Activity at Pseudomonas aeruginosa 531 beta-lactamase BEL-2 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID528731 | Antibacterial activity against penicillin intermediate Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID356755 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by microbroth dilution method | 2001 | Journal of natural products, Jul, Volume: 64, Issue:7 | Biological and mechanistic activities of xanthorrizol and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol isolated from Iostephane heterophylla. |
| AID620349 | Antibacterial activity against Escherichia coli RCMB 000103 at 30 ug/ml after 24 hrs by diffusion agar technique | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Synthesis and anti-microbial activity of some 1- substituted amino-4,6-dimethyl-2-oxo-pyridine-3-carbonitrile derivatives. |
| AID634231 | Antibacterial activity against Streptococcus sobrinus ATCC 33478 assessed as growth inhibition at 0.00625 to 2.5 ug/ml after 24 hrs by microplate dilution assay | 2011 | Journal of natural products, Dec-27, Volume: 74, Issue:12 | Isoflavonoids and coumarins from Glycyrrhiza uralensis: antibacterial activity against oral pathogens and conversion of isoflavans into isoflavan-quinones during purification. |
| AID554866 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F ST 2917 harboring ERY-resistant erm(B) and mef(E) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID340766 | Antibacterial activity against wild type penicillin-susceptible Streptococcus gordonii at 2 times MIC | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID422497 | Ratio of Kcat to Km of Carnobacterium divergens BM4489 penicillinase Cad-1 | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID757813 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | Design, synthesis and antibacterial activity studies of thiazole derivatives as potent ecKAS III inhibitors. |
| AID1180448 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus H 5996/08 after 48 hrs by microdilution method | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates. |
| AID530506 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype II isolate 9051-04 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID528722 | Antibacterial activity against Streptococcus viridans clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID524871 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea assessed as incidence of resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID528521 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC BAA-611 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID534082 | Antibacterial activity against cefotaxime-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID573394 | Antibacterial activity against Bacteroides fragilis by by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID524646 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA, ponA and mtrR mutant gene assessed as incidence of susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID528709 | Antibacterial activity against penicillin resistant Streptococcus pneumoniae clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID325444 | Antibacterial activity against Escherichia coli K12 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID611682 | Antifungal activity against Microbotryum violaceum at 0.05 mg by agar diffusion method | 2011 | Journal of natural products, Jul-22, Volume: 74, Issue:7 | Bioactive 11,20-epoxy-3,5(16)-diene briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. |
| AID576902 | Antimicrobial activity against Bacillus anthracis Sterne 7702 selected at 80 uM after 6 passages by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Oligochlorophens are potent inhibitors of Bacillus anthracis. |
| AID577450 | Antimicrobial activity against penicillin intermediate resistant Streptococcus pneumoniae isolate 8882 harboring PBP2b 443SSNA mutant by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID1546641 | Antibacterial activity against Staphylococcus epidermidis assessed as diameter of zone of inhibition at 200 ug/ml after 24 hrs by agar well diffusion method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1 | Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents. |
| AID534087 | Antibacterial activity against levofloxacin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID1638896 | Antimicrobial activity against penicillin-resistant Staphylococcus aureus ATCC 29213 measured after 18 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action. |
| AID520406 | Antimicrobial activity against quinolone-resistant Streptococcus pneumoniae by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID519627 | Antimicrobial activity against Brachyspira pilosicoli 80.10 without producing beta-lactamase OXA-63 by disc diffusion method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID278534 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium animalis ATCC 27536 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID529894 | Antimicrobial activity against Leptospira interrogans serovar Grippotyphosa isolate 2 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID557471 | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae 1077 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID278675 | Antibacterial activity against Enterococcus faecalis isolate 5743 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID573385 | Antibacterial activity against beta lactamase-positive Moraxella catarrhalis by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID368307 | Activity of Klebsiella pneumoniae SHV1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID495664 | Ratio of Kcat to Km for Pseudomonas aeruginosa 51170 beta-lactamase BEL-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID554877 | Antimicrobial activity against Streptococcus pneumoniae serotype 6B ST 138 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID540968 | Ratio of Kcat to Km for Salmonella enterica serotype Newport AM17274 cephalosporinase CMY-31 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID524046 | Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID530507 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 3444-99 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID531575 | Antibacterial activity against Bacillus spp. obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1072986 | Antimicrobial activity against Streptococcus pneumoniae CL 2883 grown in iso sensitet medium after 20 hrs by 2-fold serial broth dilution method | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Isolation, structure elucidation, and biological activity of altersolanol P using Staphylococcus aureus fitness test based genome-wide screening. |
| AID604261 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT colorimetric method | 2011 | Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13 | 4-alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation. |
| AID486254 | Antibacterial activity against Escherichia coli NCIM 2065 after 24 hrs by disc diffusion method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Synthesis and biological evaluation of beta-chloro vinyl chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity. |
| AID495842 | Hydrolytic activity of Escherichia coli DH10B beta-lactamase VIM-2 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID210403 | In vitro Minimum inhibitory concentration against Streptococcus pyogenes ATCC 8668 | 1981 | Journal of medicinal chemistry, Oct, Volume: 24, Issue:10 | Synthesis and evaluation of ureido- and vinylureidopenicillins as inhibitors of intraruminal lactic acid production. |
| AID1054742 | Antibacterial activity against Escherichia coli ATCC 35218 assessed as growth inhibition after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Schiff's base derivatives bearing nitroimidazole moiety: new class of antibacterial, anticancer agents and potential EGFR tyrosine kinase inhibitors. |
| AID406553 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 24 hrs by serial dilution method | 2008 | Bioorganic & medicinal chemistry, Jul-01, Volume: 16, Issue:13 | Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis. |
| AID529327 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae serotype 6B ATCC 700670 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID28559 | Concentration of compound in human blood tissues after intravenous administration of 2 g dose | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. Synthesis and properties of some dihydropyridine and dihydroiosquinoline derivatives of benzylpenicillin. |
| AID420258 | Inhibition of Streptococcus pneumoniae 5204 PBP2x assessed as residual activity at 100 uM after 16 hrs | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Large ring 1,3-bridged 2-azetidinones: experimental and theoretical studies. |
| AID619773 | Antibacterial activity against Pseudomonas aeruginosa RCMB 000102 at 30 mg/ml after 24 hrs by agar well diffusion method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Design and synthesis of some new thiophene, thienopyrimidine and thienothiadiazine derivatives of antipyrine as potential antimicrobial agents. |
| AID524973 | Antibacterial activity against Streptococcus agalactiae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID557394 | Antibacterial activity against Beta-lactamase-negative Neisseria meningitidis assessed as percent resistant isolates by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. |
| AID368525 | Ratio of Kcat to Km of Enterobacter cloacae 4080 AmpC (P99) assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID533930 | Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus NRS119 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID554874 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 2678 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID625446 | Antimicrobial activity against Staphylococcus aureus MTCC 96 by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Iodine-catalyzed conjugate addition of indoles onto en-1,4-dione: a novel synthesis of 3-(1-(1H-indol-3-yl)-2-oxo-2-phenylethyl)indolin-2-ones as antibacterial and antifungal agents. |
| AID557267 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae 24 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID574951 | Antimicrobial activity against Streptococcus pneumoniae serotype 7F by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID587962 | Activity of Escherichia coli beta-lactamase Toho-1 N104A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID171270 | Concentration of compound in rat lung after intravenous injection of 20 mg/kg benzyl-penicillin after 60 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID1870119 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4862/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID562374 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus pyogenes clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID21916 | Relative hydrolysis rate (RHR) was evaluated against Staphylococcus aureus with the strain FS108 | 1984 | Journal of medicinal chemistry, Mar, Volume: 27, Issue:3 | Dependence of beta-lactamase stability on substructures within beta-lactam antibiotics. |
| AID528704 | Antibacterial activity against Streptococcus intermedius clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID420256 | Inhibition of methicillin-resistant Staphylococcus aureus ATCC 433000 PBP2a assessed as residual activity at 100 uM after 16 hrs | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Large ring 1,3-bridged 2-azetidinones: experimental and theoretical studies. |
| AID495710 | Kcat/Km ratio of Klebsiella pneumoniae KPC-2 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID558616 | Antimicrobial activity against Streptococcus pneumoniae isolate 2880 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID776440 | Antibacterial activity against Bacillus cereus ATCC 14579 after 24 hrs by microdilution technique | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives. |
| AID278535 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium bifidum R0071 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID322505 | Volume of distribution at steady state in human very low birth weight preterm neonates at 14 mg/kg, iv | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID565815 | Antimicrobial activity against Neisseria gonorrhoeae assessed as resistant isolates by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Update on fusidic acid (CEM-102) tested against Neisseria gonorrhoeae and Chlamydia trachomatis. |
| AID558610 | Antimicrobial activity against Streptococcus pneumoniae isolate 1424 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID573124 | Antibacterial activity against coagulase-negative and oxacillin-resistant Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID524690 | Antibacterial activity against penicillin-nonsusceptible Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID451349 | Antimicrobial activity against Bacillus subtilis NBRC3134 after 24 hrs by broth dilution method | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. |
| AID542613 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338A mutant gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID278922 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID562586 | Antimicrobial activity against Streptococcus agalactiae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1321402 | Bactericidal activity against Staphylococcus aureus ATCC 29213 by broth microdilution method | 2016 | Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19 | The Rational Design, Synthesis, and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine Kinases. |
| AID278525 | Antimicrobial activity against Bifidobacterium breve ATCC 15700 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID524975 | Antibacterial activity against Streptococcus sp. Group F clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID207700 | In vitro antimicrobial activity against Staphylococcus aureus FDA 209P was determined | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Design, synthesis, and SAR of novel carbapenem antibiotics with high stability to Xanthomonas maltophilia oxyiminocephalosporinase type II. |
| AID278537 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium breve ATCC 15700 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID520407 | Antimicrobial activity against trimethoprim-sulfamethoxazole-susceptible Streptococcus pneumoniae by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID540212 | Mean residence time in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID374669 | Antimicrobial activity against tetracycline-resistant Escherichia coli U1 rapA mutant grown as planktonic cells after 24 hrs by spectrophotometric method | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID520387 | Ratio of Kcat to Km for Pseudomonas aeruginosa M5109 metallo-beta-lactamase VIM-11 | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID557492 | Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID573600 | Antibacterial activity against Fusobacterium mortiferum assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID498378 | Antimicrobial activity against erythromycin- and streptomycin-resistant Streptococcus gordonii Tol1 harboring R483P mutation in ptsI infected in Wistar rat assessed as protection against bacterial infection at 300000 U/kg, sc administered 16 hrs after inf | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | A single mutation in enzyme I of the sugar phosphotransferase system confers penicillin tolerance to Streptococcus gordonii. |
| AID150758 | P-gp activity was measured by a direct transport assay, using polarized LLC-PK1 epithelial cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID576741 | Antimicrobial activity against Bacillus anthracis by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Oligochlorophens are potent inhibitors of Bacillus anthracis. |
| AID571189 | Antibacterial activity against Neisseria gonorrhoeae harboring Asp-345a insertion in penA and DA G101D mutant genes by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID1063966 | Antibacterial activity against Staphylococcus aureus CCM 4516/08 after 48 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID528606 | Activity of Escherichia coli 2138 beta-lactamase KPC-2 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID520413 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID541022 | Activity at Burkholderia cenocepacia 07-34 beta-lactamase PenB1 expressed in Escherichia coli Top10 by UV-spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID565810 | Antimicrobial activity against Neisseria meningitidis by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Determination of CEM-101 activity tested against clinical isolates of Neisseria meningitidis from a worldwide collection. |
| AID573132 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID163928 | In vitro antimicrobial activity against Pseudomonas aeruginosa 18S-H was determined | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Design, synthesis, and SAR of novel carbapenem antibiotics with high stability to Xanthomonas maltophilia oxyiminocephalosporinase type II. |
| AID369007 | Sensitivity of Staphylococcus aureus isolated from lactating Holstein bovine subclinical mastitis model at 10 ug/disk after 20 hrs | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Therapeutic effect of nisin Z on subclinical mastitis in lactating cows. |
| AID1309203 | Antibacterial activity against Ralstonia solanacearum by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Four new minor brominated indole related alkaloids with antibacterial activities from Laurencia similis. |
| AID561253 | Antibacterial activity against Streptococcus pyogenes by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID770971 | Antibacterial activity against Escherichia coli MTCC 443 by broth dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Demonic axe-like conjugated alkynes in combating microbes. |
| AID368729 | Activity of Pseudomonas aeruginosa AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID535643 | Antimicrobial activity against Group B streptococcus serotype III N3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID1237613 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC62202 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID562366 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group F clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID557481 | Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID425336 | Antibacterial activity against penicillin-intermediate Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. |
| AID574952 | Antimicrobial activity against Streptococcus pneumoniae serotype 11A by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID287371 | Antibacterial activity against Escherichia coli after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID519008 | Activity of Beta-lactamase TEM-149 expressed in Escherichia coli HB101 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID519994 | Antimicrobial activity against Streptococcus pneumoniae harboring erm(B) gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID561106 | Antibacterial activity against Pasteurella multocida BB1040 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID531567 | Antibacterial activity against Streptococcus agalactiae obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID278679 | Antibacterial activity against Enterococcus faecium isolate 5750 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID1237604 | Antibacterial activity against Staphylococcus epidermidis ATCC12228 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID1706286 | Protein binding in plasma (unknown origin) | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | β-lactam antibiotics: An overview from a medicinal chemistry perspective. |
| AID171113 | Concentration of compound in rat blood after intravenous injection of 20 mg/kg benzyl-penicillin after 60 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID575076 | Antimicrobial activity against Streptococcus pneumoniae serotype 19A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1348085 | Antimicrobial activity against Klebsiella oxytoca ATCC 8724 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID519013 | Ratio of Kcat to Km for Beta-lactamase TEM-10 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID666596 | Antibacterial activity against Staphylococcus aureus after 16 hrs by broth dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Facile synthesis, cytotoxic and antimicrobial activity studies of a new group of 6-aryl-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines. |
| AID394490 | Ratio of Vmax to Km for Hafnia alvei beta-lactamase ACC-1 | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID776433 | Antibacterial activity against Staphylococcus aureus ATCC 12600 at 10 mg/ml after 48 hrs by disc-diffusion method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives. |
| AID245437 | Minimum inhibitory concentration against Bacillus sphaericus (Gram-positive) was determined by broth dilution method | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of 2,4,6-tri substituted s-triazines. |
| AID269450 | Antibacterial activity against ampC beta-lactamase Enterobacter cloacae P99 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID573592 | Antibacterial activity against Fusobacterium mortiferum by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID171114 | Concentration of compound in rat brain after intravenous injection of 20 mg/kg benzyl-penicillin after 1 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID540184 | Antibacterial activity against Pseudomonas aeruginosa NCIM 2035 after 24 hrs by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and anti-tubercular and antimicrobial activities of some 2r,4c-diaryl-3-azabicyclo[3.3.1]nonan-9-one N-isonicotinoylhydrazone derivatives. |
| AID524661 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea assessed as percentage intermediate isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID561496 | Antibacterial activity against Moraxella catarrhalis by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID1279007 | Antibacterial activity against Staphylococcus aureus CCM 4516/08 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID520403 | Antimicrobial activity against macrolide-susceptible Streptococcus pneumoniae by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID548746 | Antimicrobial activity against viridans group Streptococcus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID585176 | Activity of Beta-lactamase GES-7 K104, G170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID1765576 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID540966 | Activity of Salmonella enterica serotype Newport AM17274 cephalosporinase CMY-31 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID565735 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group C clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID535636 | Antimicrobial activity against Group B streptococcus serotype VI R4 harboring Q557E mutation in PBP 2X and T567I, Y262N mutations in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID1354713 | Antimicrobial activity against Staphylococcus aureus subsp. aureus Rosenbach ATCC 25923 after 24 hrs by serial dilution method | |||
| AID341348 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 22 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID543275 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x and pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID567281 | Ratio of Kcat to Km for Acinetobacter baumannii ADC-33 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID543270 | Antimicrobial activity against Streptococcus pneumoniae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID368526 | Ratio of Kcat to Km of Enterobacter cloacae 4080 AmpC (P99) assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID575338 | Antimicrobial activity against Listeria monocytogenes EGD-e at 5 ug after 16 hrs by disk diffusion assay | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics. |
| AID521352 | Antimicrobial activity against Streptococcus pneumoniae ATCC BAA-612 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID521831 | Antimicrobial activity against Streptococcus pneumoniae isolated from meningitis patient assessed as percent resistant isolates by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID1193541 | Antibacterial activity against Escherichia coli ATCC 25922 at 100 ug after 24 hrs | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. |
| AID285271 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM1 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID511534 | Antimicrobial activity against Streptococcus uberis isolate 20618 harboring PAP1A G386R and PBP2X E381K/Q554E mutation assessed as inhibition of visible growth after 24 hrs by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID571182 | Antibacterial activity against Neisseria gonorrhoeae harboring ponA L421P mutant gene by disk agar diffusion method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID495731 | Kcat/Km ratio of Escherichia coli TEM-1 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID574956 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 6B by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1437661 | Antibacterial activity against Staphylococcus haemolyticus CICC 10373 after 20 to 24 hrs by two-fold microdilution method | |||
| AID285442 | Activity of Citrobacter gillenii CIP 106783 Beta-lactamase GIL1 expressed in Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID496405 | Antimicrobial activity against Borrelia burgdorferi B31 | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Ineffectiveness of tigecycline against persistent Borrelia burgdorferi. |
| AID559859 | Antimicrobial activity against Streptococcus agalactiae clinical isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Capsular type and antibiotic resistance in Streptococcus agalactiae isolates from patients, ranging from newborns to the elderly, with invasive infections. |
| AID1157278 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus by resazurin-based assay | 2014 | Journal of natural products, May-23, Volume: 77, Issue:5 | Mahorones, highly brominated cyclopentenones from the red alga Asparagopsis taxiformis. |
| AID1601845 | Antibacterial activity against Enterococcus faecalis CMCC 29212 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID428137 | Antimicrobial activity against penicillin-resistant Streptococcus gordonii PR1_2evolved mutant co-cultured with wild type Streptococcus gordoni assessed as loss of viability at stationary phase of growth at 0.5 ug/mL after 70 hrs relative to wild type | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory. |
| AID341337 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 83 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID557487 | Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID565813 | Antimicrobial activity against Neisseria gonorrhoeae assessed as susceptible isolates by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Update on fusidic acid (CEM-102) tested against Neisseria gonorrhoeae and Chlamydia trachomatis. |
| AID524665 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA and penB mutant gene assessed as percentage intermediate isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID662526 | Antimicrobial activity against Escherichia coli ATCC 25922 after 18 to 20 hrs by spectrophotometry | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12 | Discovery of potent antimicrobial peptide analogs of Ixosin-B. |
| AID534394 | Activity of Beta-lactamase KHM-1 in Escherichia coli JM109 harboring recombinant pKHM-1 assessed as compound hydrolysis by UV-visible spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate. |
| AID542625 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x2349 mutant gene, disruption in PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID322513 | Effect on glomerular filtration in human very low birth weight preterm neonates urine assessed as creatinine excretion at 15 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID200524 | Minimum inhibitory concentration against aerobic organism Salmonella schottmuelleri 2837 | 1982 | Journal of medicinal chemistry, Apr, Volume: 25, Issue:4 | Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain. |
| AID534154 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis 3124 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID1454343 | Antibacterial activity Escherichia coli MTCC 443 by agar well method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis and biological evaluation of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thioglycosides. |
| AID524048 | Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID532678 | Antimicrobial activity against ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates assessed as resistant isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal. |
| AID285270 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM36 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID428126 | Antimicrobial activity against wild type Streptococcus gordonii | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory. |
| AID524641 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penB mutant gene assessed as incidence of susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID375920 | Antibacterial activity against Bacillus cereus ATCC 11778 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents. |
| AID486416 | Antibacterial activity against Proteus vulgaris NCIM 2813 after 24 hrs by disc diffusion method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Synthesis and biological evaluation of beta-chloro vinyl chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity. |
| AID483191 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by microbroth dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID368517 | Ratio of Kcat to Km of Pseudomonas aeruginosa VIM2 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1237612 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC513045 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID378415 | Antimicrobial activity against Trichoderma harzianum ATCC 64870 after 24 hrs | 2006 | Journal of natural products, Aug, Volume: 69, Issue:8 | Carneic acids A and B, chemotaxonomically significant antimicrobial agents from the xylariaceous ascomycete Hypoxylon carneum. |
| AID493656 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 13525 by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors. |
| AID495703 | Kcat/Km ratio of Escherichia coli CTX-M-15 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID508387 | Antibacterial activity against macrolide-resistant Streptococcus pyogenes harboring mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID368532 | Activity of Morganella morganii AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1870124 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4482/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID619674 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 by broth microdilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives. |
| AID324361 | Activity of Acinetobacter johnsonii SCO1 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. |
| AID374363 | Activity of Aeromonas caviae A324R metallo-beta-lactamase IMP-19 expressed in Escherichia coli DH5alpha by computerized microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France. |
| AID495739 | Kcat/Km ratio of Pseudomonas aeruginosa OXA-10 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID1454342 | Antibacterial activity Staphylococcus epidermidis MTCC 9041 by agar well method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis and biological evaluation of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thioglycosides. |
| AID529666 | Ratio of Kcat to Km for Pseudomonas aeruginosa COL-1 beta-lactamase VIM-2 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID548533 | Antimicrobial activity against Beta-hemolytic Streptococcus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID278552 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum ATCC 15707 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1279019 | Antibacterial activity against ESBL-positive Klebsiella pneumoniae J 14368/08 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID418564 | Antibacterial activity against Clostridium perfringens ATCC 10388 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents. |
| AID442478 | Antibacterial activity against Staphylococcus aureus MTCC 96 by broth dilution method | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1 | Click chemistry: studies on the synthesis of novel fluorous tagged triazol-4-yl substituted quinazoline derivatives and their biological evaluation--theoretical and experimental validation. |
| AID368514 | Activity of Pseudomonas aeruginosa VIM2 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID207408 | Minimum protective concentration against beta-lactamase of Staphylococcus aureus 95 | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Design, synthesis, and SAR of novel carbapenem antibiotics with high stability to Xanthomonas maltophilia oxyiminocephalosporinase type II. |
| AID68518 | Minimum inhibitory concentration against aerobic organism Enterobacter cloacae 2646 | 1982 | Journal of medicinal chemistry, Apr, Volume: 25, Issue:4 | Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain. |
| AID322516 | Effect on glomerular filtration in human very low birth weight preterm neonates urine assessed as drug clearance at 30 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID1870126 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4504/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID368505 | Activity of Escherichia coli KPC2 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID519009 | Ratio of Kcat to Km for Beta-lactamase TEM-149 expressed in Escherichia coli HB101 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID508380 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae harboring mutation in L4 ribosomal protein after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID575147 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus VRS1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID524642 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA and penB mutant gene assessed as incidence of susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID558324 | Antibacterial activity against bla gene-negative and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P835 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID573572 | Antibacterial activity against beta-lactamase producing Bacteroides uniformis by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID508388 | Antibacterial activity against macrolide-resistant Streptococcus pyogenes harboring erm(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID543282 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp1a, pbp2b genes and Streptococcus pneumoniae 3191 genomic DNA by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID368511 | Ratio of Kcat to Km of Serratia marcescens SME3 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID520383 | Antimicrobial activity Escherichia coli DH5alpha expressing metallo-beta-lactamase VIM-11 by agar macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID559063 | Antibacterial activity against Streptococcus constellatus by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID1638907 | Antimicrobial activity against Ampc beta-lactamase expressing Enterobacter cloacae ATCC BAA-1143 measured after 18 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action. |
| AID508291 | Antimicrobial activity against Enterococcus faecium D63 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID495724 | Activity of Pseudomonas aeruginosa OXA-10 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID372618 | Ratio of Kcat to Km for Escherichia coli CF0042 beta-lactamase TEM-35 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID524978 | Antibacterial activity against Streptococcus constellatus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID532986 | Antibacterial activity against Pseudomonas aeruginosa NCIM 5029 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID557499 | Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID533874 | Antibacterial activity against penicillin-nonsusceptible Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID395402 | Antibacterial activity against Pseudomonas aeruginosa MTCC 1688 at 20 ug after 24 hrs by cup diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis of new series of 5,6-dihydro-4H-1,2-oxazines via hetero Diels-Alder reaction and evaluation of antimicrobial activity. |
| AID554865 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F ST 2694 harboring ERY-resistant mef(E) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID524664 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penB mutant gene assessed as percentage intermediate isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID546431 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-2 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID495692 | Activity of Pseudomonas aeruginosa AmpC | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID519205 | Antibacterial activity against Streptococcus pneumoniae by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | In vitro activity of AR-709 against Streptococcus pneumoniae. |
| AID1271949 | Antibacterial activity against Staphylococcus aureus assessed as growth inhibition at 10 mg/ml by drug sensitive assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Novel skeleton compound Allomyrinanoid A and two purine alkaloids from the adult of Allomyrina dichotoma L. |
| AID558614 | Antimicrobial activity against Streptococcus pneumoniae isolate 2688 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1072980 | Antimicrobial activity against vancomycin-sensitive Enterococcus faecalis CL 8516 after 20 hrs by 2-fold serial broth dilution method | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Isolation, structure elucidation, and biological activity of altersolanol P using Staphylococcus aureus fitness test based genome-wide screening. |
| AID543274 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2b, pbp1a and murM genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID539693 | Antifungal activity against Escherichia coli MTCC 443 by broth dilution method | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | Indium(III) chloride catalyzed three-component coupling reaction: a novel synthesis of 2-substituted aryl(indolyl)kojic acid derivatives as potent antifungal and antibacterial agents. |
| AID558644 | Antimicrobial activity against compound-susceptible Streptococcus pneumoniae by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID558332 | Antibacterial activity against Campylobacter jejuni isolate P338 harboring blaOXA-61::cat gene by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID368312 | Ratio of Kcat to Km of Staphylococcus aureus betalactamase PC1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID660261 | Ratio of MIC for wild type Escherichia coli JC7623 to MIC for acrAB-deficient Escherichia coli JZM120 | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID522654 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis K4539 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID1279011 | Antibacterial activity against Staphylococcus epidermidis H 6966/08 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID557470 | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae 1076 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID269455 | Antibacterial activity against Klebsiella pneumoniae ATCC 8308 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID554868 | Antimicrobial activity against Streptococcus pneumoniae serotype 23F ST 81 harboring ERY-resistant mef(E) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID543285 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 genomic DNA, pbp2x, pbp1a, pbp2b and Streptococcus pneumoniae 3191 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID534089 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID451357 | Antimicrobial activity against Saccharomyces cerevisiae NBRC10114 after 24 hrs by broth dilution method | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. |
| AID569345 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID520395 | Antibacterial activity against erm(B) and mef(E)-positive Streptococcus pneumoniae isolate Sweden 15A-25 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID558333 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P790 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID1638903 | Antimicrobial activity against NDM1 beta -lactamse expressing Escherichia coli ATCC BAA-2469 measured after 18 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action. |
| AID529662 | Ratio of Kcat to Km for Pseudomonas aeruginosa 9551 beta-lactamase VIM-15 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID531568 | Antibacterial activity against Streptococcus pyogenes obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID530500 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype IA isolate 5662-05 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID340762 | Antibacterial activity against Streptococcus gordonii with non penicillin binding protein mutation | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID528534 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B503 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID746785 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 18 to 20 hrs by macrobroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, May-15, Volume: 23, Issue:10 | Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide. |
| AID533881 | Antibacterial activity against cefotaxime-intermediate Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID535633 | Antimicrobial activity against Group B streptococcus serotype Ia R7 harboring T77I, F395V and S353F in PBP 2X; V80A and G613R in PBP 2B; and L45P, N163K, N723S and Y470F in PBP 1A by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID619677 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 by broth microdilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives. |
| AID1778126 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus assessed as microbial growth inhibition by CLSI-protocol based broth microdilution assay | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4 | Opportunities and Limitations for Assigning Relative Configurations of Antibacterial Bislactones using GIAO NMR Shift Calculations. |
| AID495729 | Activity of Pseudomonas aeruginosa SPM-1 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID531450 | Antibacterial activity against Streptococcus pneumoniae serotype 15A assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID565811 | Antimicrobial activity against Neisseria meningitidis assessed as susceptible isolate by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Determination of CEM-101 activity tested against clinical isolates of Neisseria meningitidis from a worldwide collection. |
| AID574953 | Antimicrobial activity against Streptococcus pneumoniae serotype 6C by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID557494 | Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1870122 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4460/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID531574 | Antibacterial activity against Aerococcus viridans obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID428131 | Ratio of generation time for wild type Streptococcus gordonii to generation time for penicillin-resistant Streptococcus gordonii PR1_2 mutant at mid-logarithmic phase of growth | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory. |
| AID535646 | Antimicrobial activity against Group B Streptococcus serotype III NEM 316 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID531456 | Antibacterial activity against Streptococcus pneumoniae serotype 19F assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID171263 | Concentration of compound in rat liver after intravenous injection of 20 mg/kg benzyl-penicillin after 60 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID278542 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium longum P/N 601377 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1454344 | Antibacterial activity Pseudomonas aeruginosa MTCC 1688 by agar well method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis and biological evaluation of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thioglycosides. |
| AID386908 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 13150 after 20 hrs by microdilution assay | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Functionalized chalcones with basic functionalities have antibacterial activity against drug sensitive Staphylococcus aureus. |
| AID368520 | Activity of Enterobacter cloacae 4092 AmpC (E2) assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID422494 | Antimicrobial activity against Escherichia coli BL21 (DE3) by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID524053 | Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID210363 | In vitro antibacterial activity against the gram-positive bacteria, penicillin resistant Streptococcus pneumoniae (4630) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7 | New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID325443 | Antibacterial activity against Escherichia coli K10 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID1054727 | Antibacterial activity against Staphylococcus aureus Rosenbach ATCC 9144 after overnight incubation by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Pahangensin A and B, two new antibacterial diterpenes from the rhizomes of Alpinia pahangensis Ridley. |
| AID1245115 | Antimicrobial activity against Staphylococcus aureus ATCC 6538 after 18 hrs by broth microdilution method | 2015 | Bioorganic & medicinal chemistry, Sep-15, Volume: 23, Issue:18 | Design, synthesis and molecular docking of salicylic acid derivatives containing metronidazole as a new class of antimicrobial agents. |
| AID340853 | Effect on pbp2X gene expression in penicillin-resistant Streptococcus gordonii with penicillin binding protein PR1_2 evolved mutation assessed as relative luciferase units relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID573150 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID258714 | Antibacterial activity against gram negative Klebsiella aerogenes(MTCC 39) | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1 | Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents. |
| AID372616 | Ratio of Kcat to Km for Escherichia coli DH5alpha beta-lactamase TEM-12 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID531566 | Antibacterial activity against Enterococcus faecium obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID466788 | Antibacterial activity against Pseudomonas aeruginosa ATCC 2785 | 2010 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6 | Design and synthesis of novel deoxybenzoin derivatives as FabH inhibitors and anti-inflammatory agents. |
| AID519011 | Ratio of Kcat to Km for Beta-lactamase TEM-149 T182M mutant expressed in Escherichia coli HB101 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID588107 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB G120K, A121D mutant gene, PBP1 L421P mutant gene, PBP2 XXXVIII pattern, deletion of nucleotide A from mtrA promoter, MAST 3158 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID569261 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 873 | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. |
| AID206456 | In vitro antibacterial activity against the gram-positive bacteria, penicillin resistant Staphylococcus aureus (2619) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7 | New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | |||
| AID495701 | Kcat/Km ratio of Escherichia coli TEM-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID219758 | Minimum protective concentration against beta-lactamase of Xanthomonas maltophilia GN 12873 (CXase-II) | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Design, synthesis, and SAR of novel carbapenem antibiotics with high stability to Xanthomonas maltophilia oxyiminocephalosporinase type II. |
| AID395401 | Antibacterial activity against Escherichia coli MTCC 443 at 20 ug after 24 hrs by cup diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis of new series of 5,6-dihydro-4H-1,2-oxazines via hetero Diels-Alder reaction and evaluation of antimicrobial activity. |
| AID757810 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | Design, synthesis and antibacterial activity studies of thiazole derivatives as potent ecKAS III inhibitors. |
| AID1243288 | Antimicrobial activity against Streptococcus pyogenes ATCC 19615 by standard broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Synthesis and biological evaluation of levofloxacin core-based derivatives with potent antibacterial activity against resistant Gram-positive pathogens. |
| AID679543 | TP_TRANSPORTER: inhibition of MTX uptake (MTX: 1 uM, PCG: 1000 uM) in OAT1-expressing S2 cells | 2002 | The Journal of pharmacology and experimental therapeutics, Aug, Volume: 302, Issue:2 | Characterization of methotrexate transport and its drug interactions with human organic anion transporters. |
| AID206460 | In vitro antibacterial activity against the gram-positive bacteria, penicillin sensitive Staphylococcus aureus (3849) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7 | New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID558646 | Antimicrobial activity against compound-resistant Streptococcus pneumoniae by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID572269 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 49951 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID542614 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338P mutant gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID210362 | In vitro antibacterial activity against the gram-positive bacteria, penicillin resistant Streptococcus pneumoniae (4629) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7 | New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID522653 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis K9724 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID530508 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 7037-99 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID524044 | Binding affinity to methicillin-, vancomycin-susceptible Staphylococcus aureus ATCC 29213 PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID529665 | Activity of Pseudomonas aeruginosa COL-1 beta-lactamase VIM-2 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID428129 | Antimicrobial activity against penicillin-resistant Streptococcus gordonii PR1_2 mutant assessed as generation time at mid-logarithmic phase of growth | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory. |
| AID573157 | Antibacterial activity against vancomycin-resistant Enterococcus faecium assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1054726 | Antibacterial activity against Bacillus subtilis (Ehrenberg) Cohn ATCC 6051 after overnight incubation by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Pahangensin A and B, two new antibacterial diterpenes from the rhizomes of Alpinia pahangensis Ridley. |
| AID368528 | Activity of Enterobacter cloacae 908R AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID503228 | Ratio of MIC for penicillin-resistant Streptococcus pneumoniae 38040505 to MIC for penicillin-sensitive Streptococcus pneumoniae R6 | 2007 | Nature chemical biology, Sep, Volume: 3, Issue:9 | Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. |
| AID508374 | Antibacterial activity against Streptococcus pneumoniae harboring mutation in 23S rRNA after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID466786 | Antibacterial activity against Escherichia coli ATCC 35218 | 2010 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6 | Design and synthesis of novel deoxybenzoin derivatives as FabH inhibitors and anti-inflammatory agents. |
| AID356760 | Antimicrobial activity against Escherichia coli 442 after 18 hrs by microbroth dilution method | 2001 | Journal of natural products, Jul, Volume: 64, Issue:7 | Biological and mechanistic activities of xanthorrizol and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol isolated from Iostephane heterophylla. |
| AID171254 | Concentration of compound in rat kidney after intravenous injection of 20 mg/kg benzyl-penicillin after 5 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID587960 | Activity of Escherichia coli beta-lactamase Toho-1 A237A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID528703 | Antibacterial activity against Streptococcus oralis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1054724 | Antibacterial activity against Salmonella sp. ATCC 700623 after overnight incubation by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Pahangensin A and B, two new antibacterial diterpenes from the rhizomes of Alpinia pahangensis Ridley. |
| AID171111 | Concentration of compound in rat blood after intravenous injection of 20 mg/kg benzyl-penicillin after 40 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID503227 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 5204 by microscopy | 2007 | Nature chemical biology, Sep, Volume: 3, Issue:9 | Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. |
| AID531421 | Antibacterial activity against Streptococcus pneumoniae serotype 35B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID568432 | Antimicrobial activity against Staphylococcus aureus MTCC 96 after 24 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Stereoselective first total synthesis, confirmation of the absolute configuration and bioevaluation of botryolide-E. |
| AID518729 | Ratio of Kcat to Km for Pseudomonas stutzeri beta-lactamase DIM-1by UV-spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID368513 | Activity of Pseudomonas aeruginosa VIM2 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID521350 | Antimicrobial activity against Streptococcus pneumoniae isolate 40 obtained from blood of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID335496 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 310 after 18 to 20 hrs by standard broth microdilution method | 2002 | Journal of natural products, Jun, Volume: 65, Issue:6 | New antimicrobial cycloartane triterpenes from Acalypha communis. |
| AID573564 | Antibacterial activity against beta-lactamase producing Bacteroides vulgatus assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID609856 | Antimicrobial activity against low-level vancomycin-resistant Enterococcus faecalis ATCC 51299 assessed as growth inhibition after 18 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Unprecedented C-2 arylation of indole with diazonium salts: Syntheses of 2,3-disubstituted indoles and their antimicrobial activity. |
| AID699541 | Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake at 20 uM incubated for 5 mins by scintillation counting | 2012 | Journal of medicinal chemistry, May-24, Volume: 55, Issue:10 | Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. |
| AID1129597 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Apr-09, Volume: 76 | Design, synthesis and molecular modeling of pyrazole-quinoline-pyridine hybrids as a new class of antimicrobial and anticancer agents. |
| AID150759 | P-gp activity was measured by a direct transport assay, using polarized LLC-mdr1a epithelial cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID368530 | Ratio of Kcat to Km of Enterobacter cloacae 908R AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID508366 | Antibacterial activity against penicillin-intermediate Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID572270 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 13709 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID524880 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA, penB and ponA mutant gene assessed as incidence of resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID528528 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B10 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID522394 | Ratio of Kcat Km for Escherichia coli K-12 Beta-lactamase AmpC | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID715625 | Antibacterial activity against Staphylococcus aureus MTCC 7443 after 24 hrs by serial dilution method | 2012 | European journal of medicinal chemistry, Nov, Volume: 57 | Synthesis, characterization, biological evaluation and QSAR studies of 11-p-substituted phenyl-12-phenyl-11a,12-dihydro-11H-indeno[2,1-c][1,5]benzothiazepines as potential antimicrobial agents. |
| AID529331 | Antibacterial activity against penicillin-cefotaxime- ceftriaxone-resistant Streptococcus pneumoniae serotype 14 URA3543 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID351195 | Half life in iv dosed neonates with gestational age of 27 to 40 weeks | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks. |
| AID493657 | Antimicrobial activity against Escherichia coli ATCC 35218 by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors. |
| AID278556 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium pseudolongum ATCC 25562 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID532988 | Antibacterial activity against Klebsiella aerogenes NCIM 2281 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID368731 | Ratio of Kcat to Km of Pseudomonas aeruginosa AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID559531 | Antibacterial activity against ciprofloxacin-susceptible Haemophilus influenzae assessed as percent susceptible isolates by CLSI M7-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID448315 | Antibacterial activity against Staphylococcus aureus MTCC 11 by broth dilution method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, photochemical E (trans)-->Z (cis) isomerization and antimicrobial activity of 2-chloro-5-methylpyridine-3-olefin derivatives. |
| AID559518 | Antibacterial activity against Streptococcus constellatus assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID524259 | Ratio of Kcat to Km in Escherichia coli beta-lactamase SHV-84 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID715627 | Antibacterial activity against Pseudomonas aeruginosa MTCC 7952 after 24 hrs by serial dilution method | 2012 | European journal of medicinal chemistry, Nov, Volume: 57 | Synthesis, characterization, biological evaluation and QSAR studies of 11-p-substituted phenyl-12-phenyl-11a,12-dihydro-11H-indeno[2,1-c][1,5]benzothiazepines as potential antimicrobial agents. |
| AID278562 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium breve R0070 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID369011 | Resistance of Staphylococcus aureus isolated from lactating Holstein bovine subclinical mastitis model at 10 ug/disk after 20 hrs | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Therapeutic effect of nisin Z on subclinical mastitis in lactating cows. |
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| AID245016 | Minimum inhibitory concentration against Klebsiella aerogenes (Gram-negative) in broth | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of 2,4,6-tri substituted s-triazines. |
| AID1254304 | Antibacterial activity against Enterococcus sp. J 14365/08 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID1149037 | Antibacterial activity against Staphylococcus aureus assessed as growth inhibition incubated for 24 hrs using mixed anhydride | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 | Beta-lactam antibiotics with N-oxide side chains. 1. Quinoxaline N-oxides. |
| AID543271 | Antimicrobial activity against Streptococcus pneumoniae 3191 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID678979 | TP_TRANSPORTER: uptake in OATP-E-expressing HEK293 cells | 2000 | Biochemical and biophysical research communications, Jun-24, Volume: 273, Issue:1 | Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. |
| AID562365 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group F clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID573798 | Antibacterial activity against Prevotella melaninogenica assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID509631 | Antimicrobial activity against Staphylococcus aureus RN4220 transformant carrying plasmid pKKS25 and expressing erm(T), dfrK and tet(L) genes by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID340768 | Increase in pbp1A gene expression in penicillin-resistant Streptococcus gordonii with penicillin binding protein PR1_2 evolved mutation assessed as relative luciferase units relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID529312 | Antibacterial activity against Streptococcus pneumoniae R6 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID335497 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium 379 after 18 to 20 hrs by standard broth microdilution method | 2002 | Journal of natural products, Jun, Volume: 65, Issue:6 | New antimicrobial cycloartane triterpenes from Acalypha communis. |
| AID368501 | Activity of Klebsiella pneumoniae TEM26 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID532981 | Antibacterial activity against Escherichia coli DH5alpha | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID588212 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID495636 | Ratio of kcat/Km for Pseudomonas luteola LAM Beta-lactamase LUT-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID558533 | Antibacterial activity against bla gene-positive and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P1698 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID368543 | Activity of Pseudomonas aeruginosa 18SH AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID565733 | Antimicrobial activity against Streptococcus Group G clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID573822 | Antibacterial activity against beta-lactamase producing Clostridium perfringens by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID562579 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group C clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1063965 | Antibacterial activity against methicillin-resistant Staphylococcus aureus H 5996/08 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID275134 | Antibacterial activity against Pseudomonas aeruginosa IAM1058 | 2007 | Journal of natural products, Jan, Volume: 70, Issue:1 | Antimicrobial arylcoumarins from Asphodelus microcarpus. |
| AID522946 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID533936 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus 131-6952X harboring plasmid borne cfr gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID529313 | Antibacterial activity against Streptococcus pneumoniae serotype 4 ATCC BAA-334 harboring mutant PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID540211 | Fraction unbound in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID447054 | Antibacterial activity against Staphylococcus aureus ATCC 6538 at 10 IU after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID573800 | Antibacterial activity against Prevotella bivia assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID558609 | Antimicrobial activity against Streptococcus pneumoniae isolate 1397 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID533942 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis 413 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID1076537 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity. |
| AID1778128 | Antimicrobial activity against Escherichia coli assessed as microbial growth inhibition by CLSI-protocol based broth microdilution assay | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4 | Opportunities and Limitations for Assigning Relative Configurations of Antibacterial Bislactones using GIAO NMR Shift Calculations. |
| AID238095 | Binding affinity for TEM-1 beta-lactamase | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3 | Molecular dynamics simulations of the TEM-1 beta-lactamase complexed with cephalothin. |
| AID436377 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT method | 2009 | European journal of medicinal chemistry, Oct, Volume: 44, Issue:10 | Synthesis, structure and structure-activity relationship analysis of 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives as potential antibacterial agents. |
| AID565742 | Antimicrobial activity against Streptococcus agalactiae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID398240 | Antimicrobial activity against Escherichia coli 389 after 18 hrs by twofold serial microbroth dilution method | 2003 | Journal of natural products, Dec, Volume: 66, Issue:12 | A novel antibacterial iridoid and triterpene from Caiophora coronata. |
| AID1254313 | Antibacterial activity against Pseudomonas aeruginosa CCM 1961 after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID603189 | Antibacterial activity against Bacillus subtilis MTCC 441 by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 21, Issue:13 | Efficient synthesis, structural characterization and anti-microbial activity of chiral aryl boronate esters of 1,2-O-isopropylidene-α-D-xylofuranose. |
| AID699540 | Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake at 20 uM incubated for 5 mins by scintillation counting | 2012 | Journal of medicinal chemistry, May-24, Volume: 55, Issue:10 | Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. |
| AID324835 | Antimicrobial activity against Neisseria gonorrhoeae 158 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID528526 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B7 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID543262 | Antimicrobial activity against Streptococcus pneumoniae R6 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID1168787 | Cytotoxicity against human macrophages assessed as cell viability after 24 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21 | Synthesis, molecular docking and biological evaluation of coumarin derivatives containing piperazine skeleton as potential antibacterial agents. |
| AID340765 | Antibacterial activity against wild type penicillin-susceptible Streptococcus gordonii at 4 times MIC | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID525548 | Antimicrobial activity against ampicillin resistant nontypeable Haemophilus influenzae isolate BB1051 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID585184 | Ratio of Kcat to Km for Beta-lactamase GES-5 E104, S170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID563974 | Activity of Klebsiella pneumoniae 05-560 beta-lactamase IMP1 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID1091742 | Antibacterial activity against Lysinibacillus sphaericus MTCC 11 assessed as growth arrest at 37 degC for 24 hr | 2009 | Chemical & pharmaceutical bulletin, Jul, Volume: 57, Issue:7 | Synthesis, nematicidal and antimicrobial properties of Bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2H-pyrazolo[3,4-d]thiazol-5-yl]phenyl]methanes. |
| AID431313 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis and structure-activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents. |
| AID528535 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B513 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID558328 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P286 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID1279008 | Antibacterial activity against Staphylococcus aureus CCM 4516/08 after 48 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID519066 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae ATCC 49619 by CLSI microdilution susceptibility testing method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Activity of the Diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America. |
| AID562376 | Antimicrobial activity against Streptococcus pyogenes clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID278530 | Antimicrobial activity against Bifidobacterium longum P/N 601377 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID565736 | Antimicrobial activity against Streptococcus Group C clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1870116 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4557/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID603193 | Antibacterial activity against Pseudomonas aeruginosa MTCC 741 by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 21, Issue:13 | Efficient synthesis, structural characterization and anti-microbial activity of chiral aryl boronate esters of 1,2-O-isopropylidene-α-D-xylofuranose. |
| AID559699 | Antimicrobial activity against Micrococcus luteus AB93113 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID1279013 | Antibacterial activity against Enterococcus sp. J 14365/08 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID278539 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium infantis ATCC 15697 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID398241 | Antimicrobial activity against Candida albicans 54 after 18 hrs by agar diffusion method | 2003 | Journal of natural products, Dec, Volume: 66, Issue:12 | A novel antibacterial iridoid and triterpene from Caiophora coronata. |
| AID378412 | Antimicrobial activity against Mucor hiemalis DSM 63298 after 24 hrs | 2006 | Journal of natural products, Aug, Volume: 69, Issue:8 | Carneic acids A and B, chemotaxonomically significant antimicrobial agents from the xylariaceous ascomycete Hypoxylon carneum. |
| AID524667 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA, penB and mtrR mutant gene assessed as percentage intermediate isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID565814 | Antimicrobial activity against Neisseria gonorrhoeae assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Update on fusidic acid (CEM-102) tested against Neisseria gonorrhoeae and Chlamydia trachomatis. |
| AID322497 | Cmin in human very low birth weight preterm neonates at 14 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID495712 | Kcat/Km ratio of Pseudomonas aeruginosa VIM-2 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID508293 | Antimicrobial activity against penicillin-resistant Enterococcus faecium D63r assessed as bacterial killing at 4 times MIC by time kill curve method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID519628 | Antimicrobial activity against beta-lactamase OXA-63 producing Brachyspira pilosicoli isolate BM4442 isolated from feces of patient with diarrhea by disc diffusion method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID372896 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Apr, Volume: 44, Issue:4 | Synthesis, characterization and structure-activity relationship analysis of novel depsides as potential antibacterials. |
| AID486414 | Antibacterial activity against Klebsiella pneumoniae NCIM 5082 after 24 hrs by disc diffusion method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Synthesis and biological evaluation of beta-chloro vinyl chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity. |
| AID776432 | Antibacterial activity against Bacillus cereus ATCC 14579 at 10 mg/ml after 48 hrs by disc-diffusion method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives. |
| AID1428255 | Antibacterial activity against Escherichia coli RCMB 000106 assessed as zone of inhibition at 30 ug/ml | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold. |
| AID395403 | Antibacterial activity against Staphylococcus aureus MTCC 737 at 20 ug after 24 hrs by cup diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis of new series of 5,6-dihydro-4H-1,2-oxazines via hetero Diels-Alder reaction and evaluation of antimicrobial activity. |
| AID368489 | Activity of Klebsiella pneumoniae SHV1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID372619 | Activity of Escherichia coli DH5alpha beta-lactamase TEM-1 by microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID559062 | Antibacterial activity against Streptococcus bovis by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID567280 | Activity of Acinetobacter baumannii ADC-11 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID368503 | Ratio of Kcat to Km of Klebsiella pneumoniae TEM26 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID582268 | Ratio of MIC for Bacillus cereus ATCC 4342 selected after 20 daily cycles of drug selection followed by 5 days of nonselective growth to MIC for Bacillus cereus ATCC 4342 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Efficacy of oritavancin in a murine model of Bacillus anthracis spore inhalation anthrax. |
| AID524045 | Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID558337 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1650 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID269454 | Antibacterial activity against Salmonella enterica ATCC 13311 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID418555 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents. |
| AID451360 | Antimicrobial activity against Paecilomyces variotii NBRC4855 after 24 hrs by broth dilution method | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. |
| AID278565 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum R0175 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID322491 | Half life in human adults at 600 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID535356 | Antimicrobial activity against Streptococcus pyogenes clinical isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID554873 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 13 harboring ERY-resistant mef(E) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID531316 | Ratio of Kcat to Km for Pseudomonas aeruginosa beta-lactamase VIM-2 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID1437660 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 20 to 24 hrs by two-fold microdilution method | |||
| AID325446 | Antibacterial activity against Salmonella enterica serovar Typhimurium LT2 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID562368 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group G clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID524056 | Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP2a by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID322515 | Effect on glomerular filtration in human very low birth weight preterm neonates urine assessed as creatinine clearance at 15 mg/kg, iv administered every 12 hr after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID625286 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID368309 | Activity of Escherichia coli TEM1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID557516 | Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID548745 | Antimicrobial activity against Beta-hemolytic Streptococcus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID425337 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. |
| AID1129599 | Antibacterial activity against Pseudomonas aeruginosa ATCC 13525 after 24 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Apr-09, Volume: 76 | Design, synthesis and molecular modeling of pyrazole-quinoline-pyridine hybrids as a new class of antimicrobial and anticancer agents. |
| AID524982 | Antibacterial activity against Streptococcus sanguinis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID447060 | Antibacterial activity against Listeria monocytogenes ATCC 15313 at 10 IU after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID522390 | Activity of Escherichia coli K-12 Beta-lactamase AmpC | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID558603 | Antimicrobial activity against Streptococcus pneumoniae isolate 37 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1161141 | Antimicrobial activity against Escherichia coli isolate 1 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID1254310 | Antibacterial activity against ESBL-positive Klebsiella pneumoniae J 14368/08 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID558539 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter coli isolate P1826 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID1309198 | Antibacterial activity against Bacillus subtilis by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Four new minor brominated indole related alkaloids with antibacterial activities from Laurencia similis. |
| AID1349908 | Antimicrobial activity against Bacillus subtilis DSM10 after 16 to 48 hrs by serial dilution method | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Cysteine-Derived Pleurotin Congeners from the Nematode-Trapping Basidiomycete Hohenbuehelia grisea. |
| AID356758 | Antimicrobial activity against Bacillus subtilis 327 after 18 hrs by microbroth dilution method | 2001 | Journal of natural products, Jul, Volume: 64, Issue:7 | Biological and mechanistic activities of xanthorrizol and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol isolated from Iostephane heterophylla. |
| AID425866 | Antimicrobial activity against Carnobacterium divergens BM4489 expressing beta-lactamase CAD1 at 3 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID575419 | Antimicrobial activity against Listeria monocytogenes EGD-e assessed as growth inhibition after 16 hrs by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics. |
| AID1063963 | Antibacterial activity against Staphylococcus epidermidis H 6966/08 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID529896 | Antimicrobial activity against Leptospira interrogans serovar Pomona isolate 4 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID524039 | Antibacterial activity against methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID1309204 | Antibacterial activity against Xanthomonas vesicatoria by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Four new minor brominated indole related alkaloids with antibacterial activities from Laurencia similis. |
| AID495716 | Activity of Escherichia coli TEM-1 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID44042 | Stability against beta-lactamase of Staphylococcus aureus | 1984 | Journal of medicinal chemistry, Mar, Volume: 27, Issue:3 | Dependence of beta-lactamase stability on substructures within beta-lactam antibiotics. |
| AID519288 | Activity of beta lactamase OXA23 in Acinetobacter baumannii Ab13 assessed as compound hydrolysis rate per mg of protein by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Acinetobacter radioresistens as a silent source of carbapenem resistance for Acinetobacter spp. |
| AID278550 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium breve R0070 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID278678 | Antibacterial activity against Enterococcus faecium isolate 5749 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID242844 | Rate of catalysis against TEM-1 beta-lactamase | 2005 | Journal of medicinal chemistry, Feb-10, Volume: 48, Issue:3 | Molecular dynamics simulations of the TEM-1 beta-lactamase complexed with cephalothin. |
| AID340849 | Increase in pbp1A gene expression in penicillin-resistant Streptococcus gordonii with penicillin binding protein PR1_2 evolved mutation at 1/2 times MIC assessed as relative luciferase units relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID425340 | Antibacterial activity against quinolone-susceptible Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. |
| AID1437929 | Antibacterial activity against Streptococcus mutans ATCC 25175 after 24 hrs | 2017 | Journal of natural products, 01-27, Volume: 80, Issue:1 | Dibenzofurans and Pseudodepsidones from the Lichen Stereocaulon paschale Collected in Northern Quebec. |
| AID1254307 | Antibacterial activity against Escherichia coli CCM4517 after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID323866 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 459 at pH 5.5 | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin. |
| AID1210969 | Ratio of drug level in brain to plasma of 5/6 nephrectomized Sprague-Dawley rat chronic renal failure model at 1 mg/kg, im after 2 hrs by beta-counting method relative to control | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 40, Issue:1 | Effects of chronic renal failure on brain drug transporters in rats. |
| AID625292 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1546111 | Antimicrobial activity against Salmonella typhimurium | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID498375 | Antimicrobial activity against wild type streptomycin-susceptible Streptococcus gordonii infected in Wistar rat assessed as decrease in bacterial infection at 300000 U/kg, sc administered 16 hrs after infection every 12 hrs for 2 days measured within 3 da | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | A single mutation in enzyme I of the sugar phosphotransferase system confers penicillin tolerance to Streptococcus gordonii. |
| AID561108 | Antibacterial activity against Pasteurella multocida BB1042 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID374675 | Antimicrobial activity against tetracycline-resistant Escherichia coli U1 rapA mutant 24 hrs biofilms assessed as viability at 350 ug/ml after 1 hr by microtiter plate count method | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID495726 | Activity of Serratia marcescens SME-3 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID322498 | Cmin in human term neonates at 15 mg/kg, im administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID503224 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 38040505 by microscopy | 2007 | Nature chemical biology, Sep, Volume: 3, Issue:9 | Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. |
| AID508300 | Inhibition of low-affinity PBP5fm in penicillin-resistant Enterococcus faecium D63r membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID368512 | Ratio of Kcat to Km of Serratia marcescens SME3 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID530503 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype IA isolate 9012-04 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID535764 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 08-003 expressing beta-lactamase TEM-135, MLST type ST-7823 and MAST type ST-4013 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID442481 | Antibacterial activity against Pseudomonas aeruginosa MTCC 741 by broth dilution method | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1 | Click chemistry: studies on the synthesis of novel fluorous tagged triazol-4-yl substituted quinazoline derivatives and their biological evaluation--theoretical and experimental validation. |
| AID521353 | Antimicrobial activity against Streptococcus pneumoniae isolate k-421 obtained from ear of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID278554 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum R0175 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID562337 | Activity at Chryseobacterium indologenes 597 metallo-beta-lactamase IND-6 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID495723 | Activity of Enterobacter cloacae AmpC relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID557480 | Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID520382 | Antimicrobial activity Escherichia coli DH5alpha harboring bacteriophage T4 plasmid alpha omega by agar macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID324362 | Ratio of kcat to Km for Acinetobacter johnsonii SCO1 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. |
| AID529314 | Antibacterial activity against Streptococcus pneumoniae serotype 9V URA4929 harboring mutant PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID557521 | Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID524247 | Antimicrobial activity against Escherichia coli INSRA4590 expressing SHV-84 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID557523 | Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID554869 | Antimicrobial activity against Streptococcus pneumoniae serotype 23F ST 961 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID543273 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID495688 | Activity of Escherichia coli CTX-M-15 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID278549 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium breve ATCC 15700 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID431311 | Antibacterial activity against Streptococcus pneumoniae ATCC 6301 | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis and structure-activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents. |
| AID535640 | Antimicrobial activity against Group B streptococcus serotype Ib C2 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID562402 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID529328 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae serotype 19A ATCC 700673 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID542622 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338A mutant gene, disruption at PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID554675 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F ST 156 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID561258 | Antibacterial activity against Streptococcus agalactiae assessed as susceptible isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID540967 | Activity of Klebsiella pneumoniae HP205 cephalosporinase CMY-36 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID325445 | Antibacterial activity against Escherichia coli C921-61 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID368730 | Activity of Pseudomonas aeruginosa AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID495698 | Activity of Pseudomonas aeruginosa IMP-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID587732 | Activity of Pseudomonas aeruginosa strain PS 297 metallo-beta-lactamase IMP-1 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis using 100 uM nitrocefin | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID1638902 | Antimicrobial activity against Escherichia coli ATCC 25922 measured after 18 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action. |
| AID529316 | Antibacterial activity against Streptococcus pneumoniae serotype 3 URA3537 harboring mutant PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID1180455 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates. |
| AID587730 | Activity of Pseudomonas aeruginosa strain PS 297 metallo-beta-lactamase IMP-18 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis using 100 uM nitrocefin | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID1128825 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 18 hrs by broth microdilution method | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Spiromastixones A-O, antibacterial chlorodepsidones from a deep-sea-derived Spiromastix sp. fungus. |
| AID1366168 | Antibacterial activity against Staphylococcus aureus by agar dilution method | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22 | Antibacterial constituents of the plant family Amaryllidaceae. |
| AID164883 | In Vitro minimal inhibitory concentration against Pseudomonas aeruginosa (1101-75) | 1998 | Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24 | Syntheses of new isodethiaazacephems as potent antibacterial agents. |
| AID278559 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium bifidum R0071 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID558326 | Antibacterial activity against bla gene-negative and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P1962 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID373053 | Antimicrobial activity against Escherichia coli DH10B by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID171107 | Concentration of compound in rat blood after intravenous injection of 20 mg/kg benzyl-penicillin after 1 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID554879 | Antimicrobial activity against Streptococcus pneumoniae serotype 17 ST 3248 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID1183299 | Antibacterial activity against Pseudomonas aeruginosa | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Design, synthesis and anti-mycobacterial activity of 1,2,3,5-tetrasubstituted pyrrolyl-N-acetic acid derivatives. |
| AID545508 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC 34404 by microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | The synthesis of phenylalanine-derived C5-substituted rhodanines and their activity against selected methicillin-resistant Staphylococcus aureus (MRSA) strains. |
| AID448314 | Antibacterial activity against Bacillus subtilis MTCC 441 by broth dilution method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, photochemical E (trans)-->Z (cis) isomerization and antimicrobial activity of 2-chloro-5-methylpyridine-3-olefin derivatives. |
| AID565816 | Antimicrobial activity against Neisseria gonorrhoeae assessed as resistant isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Update on fusidic acid (CEM-102) tested against Neisseria gonorrhoeae and Chlamydia trachomatis. |
| AID557511 | Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID577457 | Antimicrobial activity against laboratory-derived Streptococcus pneumoniae isolate R6 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID520731 | Activity of Escherichia coli DH10B beta-lactamase OXA-97 assessed per mg of protein at 100 uM | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID522658 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis V770-NP1-R by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID368724 | Ratio of Kcat to Km of Pseudomonas aeruginosa MK-1184 AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID324847 | Antimicrobial activity against Neisseria gonorrhoeae 82 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID1870128 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4738/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID522392 | Ratio of Kcat Km for Aeromonas enteropelogenes Beta-lactamase TRU1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID1193540 | Antibacterial activity against Staphylococcus aureus ATCC 25923 at 100 ug after 24 hrs | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. |
| AID757811 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | Design, synthesis and antibacterial activity studies of thiazole derivatives as potent ecKAS III inhibitors. |
| AID569348 | Antibacterial activity against Haemophilus influenzae by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID508298 | Inhibition of PBP4 in penicillin-resistant Enterococcus faecium D63r membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID559538 | Antibacterial activity against Neisseria meningitidis assessed as percent susceptible isolates by CLSI M7-A7 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID521354 | Antimicrobial activity against Streptococcus pneumoniae isolate 4134 obtained from sputum of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID322502 | Clearance in human term neonates at 15 mg/kg, im administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID573113 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID557266 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae 2527 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID522651 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis K5926 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID374677 | Antimicrobial activity against tetracycline-resistant Escherichia coli U1 rapA mutant flow cell-generated 24 hrs biofilms using BacLight staining by CSLM | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID519635 | Activity of Brachyspira pilosicoli beta-lactamase OXA-63 expressed in Escherichia coli BL21 (DE3) assessed as compound hydrolysis by spectrophotometry relative to oxacillin | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID263113 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USF658 by agar disk diffusion method | 2006 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8 | N-thiolated 2-oxazolidinones: a new family of antibacterial agents for methicillin-resistant Staphylococcus aureus and Bacillus anthracis. |
| AID373214 | Ratio of Kcat to Km for Bacillus clausii NR beta-lactamase BCL1 to ratio of Kcat/Km for Bacillus anthracis beta-lactamase Bla1 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID1161142 | Antimicrobial activity against Escherichia coli isolate 2 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID1250522 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hr by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Synthesis and evaluation of new tyrosyl-tRNA synthetase inhibitors as antibacterial agents based on a N2-(arylacetyl)glycinanilide scaffold. |
| AID573799 | Antibacterial activity against Prevotella buccae assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1054723 | Antibacterial activity against Salmonella typhimurium (Loeffler) Castellani and Chalmers ATCC 14028 after overnight incubation by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Pahangensin A and B, two new antibacterial diterpenes from the rhizomes of Alpinia pahangensis Ridley. |
| AID557477 | Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID571191 | Antibacterial activity against Neisseria gonorrhoeae harboring wild-type penA and porB1a genes by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID522824 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis NH by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID425338 | Antibacterial activity against azithromycin-susceptible Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. |
| AID351196 | Volume of distribution in neonates | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks. |
| AID522669 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis B133 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID524244 | Antimicrobial activity against Escherichia coli DH5alpha | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID336567 | Antibacterial activity against penicillin-resistant Staphylococcus aureus ATCC 29247 after 2 days by twofold serial dilution method | 1992 | Journal of natural products, Oct, Volume: 55, Issue:10 | Antibacterial activity of totarol and its potentiation. |
| AID588213 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID528741 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC BAA-611 harboring PBP-2X V405A mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID495700 | Activity of Acinetobacter baumannii OXA-23 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID495841 | Ratio of Kcat to Km for beta-lactamase VIM-1 in Escherichia coli DH5alpha expressing pBCLL/39H by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID529897 | Antimicrobial activity against Leptospira interrogans serovar Pyrogenes isolate 5 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID562357 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID557488 | Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1279018 | Antibacterial activity against Klebsiella pneumoniae D 11750/08 after 48 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID1076535 | Inhibition of Escherichia coli N-terminal His-tagged FabH expressed in Escherichia coli BL21(DE3) using holo-acyl carrier protein as substrate preincubated for 1 min followed by acetyl-CoA addition measured after 25 mins by liquid scintillation counting a | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity. |
| AID1180451 | Antimicrobial activity against Enterococcus sp. J 14365/08 after 24 hrs by microdilution method | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates. |
| AID529454 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae serotype 19F URA3699 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID577449 | Antimicrobial activity against penicillin sensitive Streptococcus pneumoniae isolate 8865 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID528532 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B68 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID588109 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring PBP2 XXXV pattern, deletion of nucleotide A from mtrA promoter, MAST 546 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID508377 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae harboring erm(B) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID406551 | Antibacterial activity against Bacillus anthracis assessed as inhibition zone diameter at 20 ug after 24 hrs by Kirby-Bauer test | 2008 | Bioorganic & medicinal chemistry, Jul-01, Volume: 16, Issue:13 | Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis. |
| AID263108 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USF653 by agar disk diffusion method | 2006 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8 | N-thiolated 2-oxazolidinones: a new family of antibacterial agents for methicillin-resistant Staphylococcus aureus and Bacillus anthracis. |
| AID1209736 | Inhibition of human OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake at 500 uM over 20 mins relative to untreated-control | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4 | Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. |
| AID483195 | Antibacterial activity against Escherichia coli ATCC 25922 by microbroth dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID588113 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates assessed as percent resistant isolates after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID519010 | Activity of Beta-lactamase TEM-149 T182M mutant expressed in Escherichia coli HB101 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID666779 | Antibacterial activity against Bacillus megaterium at 0.05 mg by agar diffusion test | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13 | Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. |
| AID534155 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis 3128 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID498371 | Antimicrobial activity against wild type streptomycin-susceptible Streptococcus gordonii after 24 hrs by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | A single mutation in enzyme I of the sugar phosphotransferase system confers penicillin tolerance to Streptococcus gordonii. |
| AID1870138 | Antibacterial activity against wild type methicillin resistant Staphylococcus aureus 4968/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID1091738 | Antibacterial activity against Chromobacterium violaceum MTCC 2656 assessed as growth arrest at 37 degC for 24 hr | 2009 | Chemical & pharmaceutical bulletin, Jul, Volume: 57, Issue:7 | Synthesis, nematicidal and antimicrobial properties of Bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2H-pyrazolo[3,4-d]thiazol-5-yl]phenyl]methanes. |
| AID374679 | Antimicrobial activity against tetracycline-resistant Escherichia coli U1 rapA mutant nylon membrane cultivated 24 hrs biofilms at 350 ug/ml after 1 hr | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID428132 | Ratio of generation time for wild type Streptococcus gordonii to generation time for penicillin-resistant Streptococcus gordonii PR1_2evolved mutant at mid-logarithmic phase of growth | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory. |
| AID447059 | Antibacterial activity against Mycobacterium smegmatis CCM 2067 at 10 IU after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID278861 | Inhibition of metabolic activity in HeLa cells assessed as MTT reduction after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID561740 | Antibacterial activity against Beta-hemolytic Streptococcus group A assessed as susceptible isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID665396 | Antibacterial activity against Staphylococcus aureus MTCC 7443 after 24 hrs by serial dilution technique | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Synthesis, characterization, antimicrobial activities and QSAR studies of some 10a-phenylbenzo[b]indeno[1,2-e][1,4]thiazin-11(10aH)-ones. |
| AID573388 | Antibacterial activity against Pasteurella multocida by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID451351 | Antimicrobial activity against Bacillus mycoides ATCC 11778 after 24 hrs by broth dilution method | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. |
| AID341529 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 19 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID559055 | Antibacterial activity against Lancefield Streptococcus sp. 'group C' by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID531449 | Antibacterial activity against Streptococcus pneumoniae serotype 23A assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID625529 | Antimicrobial activity against Escherichia coli MTCC 443 by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Iodine-catalyzed conjugate addition of indoles onto en-1,4-dione: a novel synthesis of 3-(1-(1H-indol-3-yl)-2-oxo-2-phenylethyl)indolin-2-ones as antibacterial and antifungal agents. |
| AID74719 | Inhibition of gram positive (resistant) bacteria growth. | 1989 | Journal of medicinal chemistry, Jun, Volume: 32, Issue:6 | Synthesis and antimicrobial properties of substituted beta-aminoxypropionyl penicillins and cephalosporins. |
| AID335499 | Antimicrobial activity against Bacillus subtilis PY79 after 18 to 20 hrs by standard broth microdilution method | 2002 | Journal of natural products, Jun, Volume: 65, Issue:6 | New antimicrobial cycloartane triterpenes from Acalypha communis. |
| AID368540 | Activity of Pseudomonas aeruginosa 4352 AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID285158 | Antimicrobial susceptibility of tetracycline-resistant Streptococcus pneumoniae from respiratory tract disease patient assessed as percent resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. |
| AID557476 | Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1546170 | Antimicrobial activity against Rhodococcus equi | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID620347 | Antibacterial activity against Bacillus subtilis RCMB 000107 at 30 ug/ml after 24 hrs by diffusion agar technique | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Synthesis and anti-microbial activity of some 1- substituted amino-4,6-dimethyl-2-oxo-pyridine-3-carbonitrile derivatives. |
| AID368529 | Ratio of Kcat to Km of Enterobacter cloacae 908R AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID324841 | Antimicrobial activity against Neisseria gonorrhoeae 30 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID375911 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents. |
| AID322501 | Clearance in human very low birth weight preterm neonates at 14 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID495914 | Hydrolytic activity of beta-lactamase VIM-1 expressed in Escherichia coli TOP10 by spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID562363 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID559061 | Antibacterial activity against Streptococcus anginosus by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID368311 | Ratio of Kcat to Km of Staphylococcus aureus betalactamase PC1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1347490 | Antibacterial activity against Pseudomonas aeruginosa assessed as zone of inhibition after 24 to 48 hrs by well diffusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations. |
| AID495711 | Kcat/Km ratio of Serratia marcescens SME-3 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID619676 | Antimicrobial activity against hemolytic Streptococcus Group B CMCC 32210 by broth microdilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives. |
| AID1209732 | Drug uptake by mouse OAT3 expressed in CHO cells at 100 uM after 25 mins by HPLC/UV detection method in presence of probenecid | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4 | Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. |
| AID1354714 | Antimicrobial activity against Erysipelothrix rhusiopathiae ATCC 19414 after 24 hrs by serial dilution method | |||
| AID557208 | Antibacterial activity against Beta-lactamase-negative Neisseria meningitidis by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. |
| AID356756 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium 379 after 18 hrs by microbroth dilution method | 2001 | Journal of natural products, Jul, Volume: 64, Issue:7 | Biological and mechanistic activities of xanthorrizol and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol isolated from Iostephane heterophylla. |
| AID1565594 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by CLSI based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity. |
| AID269448 | Antibacterial activity against wild type Escherichia coli DC0 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID531318 | Ratio of Kcat to Km for Escherichia coli beta-lactamase VIM-1 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID558613 | Antimicrobial activity against Streptococcus pneumoniae isolate 2686 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID495839 | Ratio of Kcat to Km for Escherichia coli BL21 DE3 beta-lactamase VIM-19 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID587968 | Ratio of Kcat to Km for Escherichia coli wild type beta-lactamase Toho-1 assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID559523 | Antibacterial activity against Streptococcus sanguinis assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID1309199 | Antibacterial activity against Bacillus thuringiensis by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Four new minor brominated indole related alkaloids with antibacterial activities from Laurencia similis. |
| AID278860 | Antiproliferative effect against HeLa cells after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID425653 | Renal clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID585183 | Ratio of Kcat to Km for Beta-lactamase GES-2 E104, N170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID529324 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae serotype 14 URA4731 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID562339 | Ratio of Kcat to Km for Chryseobacterium indologenes 597 metallo-beta-lactamase IND-5 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID368728 | Ratio of Kcat to Km of Serratia marcescens AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID557483 | Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID171252 | Concentration of compound in rat kidney after intravenous injection of 20 mg/kg benzyl-penicillin after 3 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID533876 | Antibacterial activity against amoxicillin-intermediate Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID557519 | Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID571180 | Antibacterial activity against Neisseria gonorrhoeae harboring porB1b and DA G101D mutant genes by disk agar diffusion method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID356762 | Antimicrobial activity against Klebsiella pneumoniae 425 after 18 hrs by microbroth dilution method | 2001 | Journal of natural products, Jul, Volume: 64, Issue:7 | Biological and mechanistic activities of xanthorrizol and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol isolated from Iostephane heterophylla. |
| AID619673 | Antimicrobial activity against Escherichia coli ATCC 25922 by broth microdilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives. |
| AID508381 | Antibacterial activity against macrolide-susceptible Streptococcus pyogenes after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID571178 | Antibacterial activity against Neisseria gonorrhoeae harboring porB1a gene by disk agar diffusion method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID245455 | Minimum inhibitory concentration against Staphylococcus aureus (Gram-positive) was determined by broth dilution method | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of 2,4,6-tri substituted s-triazines. |
| AID375913 | Antibacterial activity against methicillin-resistan Staphylococcus aureus ATCC 33591 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents. |
| AID543484 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x, pbp2b, pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID533935 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus 004-737X harboring plasmid borne cfr gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID574954 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19A by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID269447 | Antibacterial activity against wild type Mycobacterium vaccae IMET10670 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID535348 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates by by based on po dosed broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID1243293 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 by standard broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Synthesis and biological evaluation of levofloxacin core-based derivatives with potent antibacterial activity against resistant Gram-positive pathogens. |
| AID486252 | Antibacterial activity against Bacillus subtilis NCIM 2546 after 24 hrs by disc diffusion method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Synthesis and biological evaluation of beta-chloro vinyl chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity. |
| AID562404 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1601844 | Antibacterial activity against Streptococcus pneumoniae CMCC 31968 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID520394 | Antibacterial activity against mef(E)-positive Streptococcus pneumoniae isolate Spain 9V-3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID1287889 | Antimicrobial activity against Bacillus subtilis MTCC 441 after 24 hrs by serial two-fold broth dilution method | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline-thiazolidine-based hybrids. |
| AID524057 | Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP2a by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID575100 | Antimicrobial activity against Streptococcus pneumoniae serotype 22F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID562582 | Antimicrobial activity against erythromycin-susceptible Streptococcus pyogenes clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID557501 | Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID524032 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 2688 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID545510 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC 700698 by microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | The synthesis of phenylalanine-derived C5-substituted rhodanines and their activity against selected methicillin-resistant Staphylococcus aureus (MRSA) strains. |
| AID599149 | Antibacterial activity against Staphylococcus aureus after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Mar, Volume: 43, Issue:3 | Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. |
| AID511447 | Antimicrobial activity against Streptococcus uberis ATCC 9529 harboring PAP1A A227T/G386R, PBP2B N366I/T402I and PBP2X E381K/D524A/Q554E mutation after 39 passages assessed as inhibition of visible growth by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID554674 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 156 harboring ERY-resistant mef(E) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID680397 | TP_TRANSPORTER: inhibition of TEA uptake (TEA: 60 uM, PCG: 5000 uM) in Xenopus laevis oocytes | 1999 | The Journal of pharmacology and experimental therapeutics, May, Volume: 289, Issue:2 | Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. |
| AID368313 | Activity of Staphylococcus aureus betalactamase PC1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID562412 | Antimicrobial activity against Streptococcus Group G clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID207407 | In vitro antimicrobial activity against Staphylococcus aureus 95 (methicillin-resistant strain) was determined | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Design, synthesis, and SAR of novel carbapenem antibiotics with high stability to Xanthomonas maltophilia oxyiminocephalosporinase type II. |
| AID322514 | Effect on glomerular filtration in human very low birth weight preterm neonates urine assessed as creatinine clearance at 30 mg/kg, iv administered every 12 hr after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID340737 | Ratio of Kcat to Km of Chryseobacterium indologenes metallo-beta-lactamase IND-5 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID1765578 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID508368 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID341526 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 23 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID364064 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Enamines as novel antibacterials and their structure-activity relationships. |
| AID531448 | Antibacterial activity against Streptococcus pneumoniae serotype 35B assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID569343 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID269452 | Antibacterial activity against Escherichia coli X580 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID573135 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus pyogenes assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID438304 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae SP328 | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19 | Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening. |
| AID575149 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus VRS3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID375914 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents. |
| AID558336 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1618 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID375918 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents. |
| AID554880 | Antimicrobial activity against Streptococcus pneumoniae serotype 6B ST 3249 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID543065 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ST398 | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Identification of a novel trimethoprim resistance gene, dfrK, in a methicillin-resistant Staphylococcus aureus ST398 strain and its physical linkage to the tetracycline resistance gene tet(L). |
| AID625283 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1511409 | Antibacterial activity against Bacillus cereus assessed as reduction in bacterial cell growth incubated for 24 hrs by filter paper assay | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21 | Synthesis and biological evaluation of calycanthaceous alkaloid analogs. |
| AID495912 | Hydrolytic activity of beta-lactamase VIM-19 expressed in Escherichia coli TOP10 by spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID498368 | Antimicrobial activity against penicillin- and streptomycin-resistant Streptococcus gordonii Tol1 harboring Tol1 mutation in ptsI assessed as bacterial count at 2 ug/ml after 24 hrs by macrodilution assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | A single mutation in enzyme I of the sugar phosphotransferase system confers penicillin tolerance to Streptococcus gordonii. |
| AID542617 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x2349 and PBP1a2349 mutant gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID561111 | Antibacterial activity against Pasteurella multocida BB1045 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID1638894 | Antibacterial activity against Bacillus subtilis 168 measured after 18 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action. |
| AID287373 | Antibacterial activity against Klebsiella pneumoniae after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID543281 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 genomic DNA, pbp2x, pbp1a and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID1064507 | Antibacterial activity against Staphylococcus epidermidis H 6966/08 after 48 hrs by microdilution broth method | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Alkylamino derivatives of pyrazinamide: synthesis and antimycobacterial evaluation. |
| AID573154 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1271947 | Antibacterial activity against Bacillus subtilis assessed as growth inhibition at 10 mg/ml by drug sensitive assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Novel skeleton compound Allomyrinanoid A and two purine alkaloids from the adult of Allomyrina dichotoma L. |
| AID278543 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium pseudolongum ATCC 25562 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID559700 | Antimicrobial activity against Bacillus thuringiensis AB93066 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID301805 | Antibacterial activity against Staphylococcus aureus ATCC 29213 | 2007 | Bioorganic & medicinal chemistry, Dec-01, Volume: 15, Issue:23 | Direct diazo-transfer reaction on beta-lactam: synthesis and preliminary biological activities of 6-triazolylpenicillanic acids. |
| AID515292 | Antibacterial activity against Staphylococcus aureus MTCC 96 by broth dilution method | 2010 | European journal of medicinal chemistry, Oct, Volume: 45, Issue:10 | Stereoselective synthesis and biological evaluation of (R)-rugulactone, (6R)-((4R)-hydroxy-6-phenyl-hex-2-enyl)-5,6-dihydro-pyran-2-one and its 4S epimer. |
| AID1347486 | Antibacterial activity against Streptococcus pyogenes assessed as zone of inhibition after 24 to 48 hrs by well diffusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations. |
| AID746787 | Antimicrobial activity against Escherichia coli ATCC 25922 after 18 to 20 hrs by macrobroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, May-15, Volume: 23, Issue:10 | Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide. |
| AID238858 | Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13 | Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. |
| AID519633 | Ratio of Kcat to Km for Brachyspira pilosicoli beta-lactamase OXA-63 expressed in Escherichia coli BL21 (DE3) assessed as compound hydrolysis by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID368506 | Activity of Escherichia coli KPC2 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID368533 | Ratio of Kcat to Km of Morganella morganii AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID531457 | Antibacterial activity against Streptococcus pneumoniae serotype 35B assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID531447 | Antibacterial activity against Streptococcus pneumoniae serotype 19F assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1191516 | Antibacterial activity against Staphylococcus epidermidis H 6966/08 after 48 hrs by broth microdilution method | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates. |
| AID1755808 | Antibacterial activity against Staphylococcus aureus ATCC 6538 incubated for 24 hrs by two fold serial dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID561109 | Antibacterial activity against Pasteurella multocida BB1043 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID495799 | Ratio of Kcat to Km of KPC-2 using nitrocefin hydrolysis | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID523002 | Cytotoxicity against human 5637 cells assessed as mild induction of cell death by LDH release assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. |
| AID575148 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus VRS2 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID1091740 | Antibacterial activity against Pseudomonas aeruginosa MTCC 741 assessed as growth arrest at 37 degC for 24 hr | 2009 | Chemical & pharmaceutical bulletin, Jul, Volume: 57, Issue:7 | Synthesis, nematicidal and antimicrobial properties of Bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2H-pyrazolo[3,4-d]thiazol-5-yl]phenyl]methanes. |
| AID573153 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID368541 | Ratio of Kcat to Km of Pseudomonas aeruginosa 4352 AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID531577 | Antibacterial activity against Gemella spp. obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID336569 | Antibacterial activity against Propionibacterium acnes ATCC 11827 after 2 days by twofold serial dilution method | 1992 | Journal of natural products, Oct, Volume: 55, Issue:10 | Antibacterial activity of totarol and its potentiation. |
| AID368538 | Ratio of Kcat to Km of Providencia stuartii AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1759748 | Binding affinity to Staphylococcus aureus ATCC 43300 50S ribosome assessed as association constant by SPR analysis | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Design, synthesis and biological evaluation of novel pleuromutilin derivatives as potent anti-MRSA agents targeting the 50S ribosome. |
| AID1072987 | Antimicrobial activity against Streptococcus pneumoniae CL 2883 grown in 2.5 % lysed horse blood medium after 20 hrs by 2-fold serial broth dilution method | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Isolation, structure elucidation, and biological activity of altersolanol P using Staphylococcus aureus fitness test based genome-wide screening. |
| AID324842 | Antimicrobial activity against Neisseria gonorrhoeae 64 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID609857 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 assessed as growth inhibition after 18 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Unprecedented C-2 arylation of indole with diazonium salts: Syntheses of 2,3-disubstituted indoles and their antimicrobial activity. |
| AID519204 | Antibacterial activity against Streptococcus pneumoniae assessed as resistant isolates by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | In vitro activity of AR-709 against Streptococcus pneumoniae. |
| AID658948 | Antibacterial activity against Serratia marcescens 155449 at 100 mg/ml after 24 hrs by agar-well diffusion technique | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | 2-Aminothiophenes as building blocks in heterocyclic synthesis: synthesis and antimicrobial evaluation of a new class of pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and pyridin-2-one derivatives. |
| AID495838 | Hydrolytic activity of Escherichia coli BL21 DE3 beta-lactamase VIM-19 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID582968 | Antimicrobial activity against beta-lactamase A and B-deficient Yersinia enterocolitica GY5718 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID379710 | Antibacterial activity against Staphylococcus aureus ATCC 6535 by modified microtiter plate assay | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Bioactive natural and semisynthetic latrunculins. |
| AID572274 | Antimicrobial activity against multiple drug-resistant Streptococcus pneumoniae ATCC 700677 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID557272 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae 3676 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID559509 | Antibacterial activity against Streptococcus agalactiae assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID529900 | Antimicrobial activity against Leptospira interrogans serovar Icterohaemorrhagiae isolate 9 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID603192 | Antibacterial activity against Escherichia coli MTCC 443 by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 21, Issue:13 | Efficient synthesis, structural characterization and anti-microbial activity of chiral aryl boronate esters of 1,2-O-isopropylidene-α-D-xylofuranose. |
| AID508386 | Antibacterial activity against macrolide-resistant Streptococcus pyogenes harboring erm(B) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID524671 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA, penB, ponA and mtrR mutant gene assessed as percentage intermediate isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID746786 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 after 18 to 20 hrs by macrobroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, May-15, Volume: 23, Issue:10 | Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide. |
| AID1366137 | Antibacterial activity against Escherichia coli assessed as diameter of inhibition zone at 1 mg/ml | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22 | Antibacterial constituents of the plant family Amaryllidaceae. |
| AID486725 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Synthesis, structure and structure-activity relationship analysis of caffeic acid amides as potential antimicrobials. |
| AID573796 | Antibacterial activity against Prevotella bivia assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID508292 | Antimicrobial activity against penicillin-resistant Enterococcus faecium D63r by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID372614 | Ratio of Kcat to Km for Escherichia coli DH5alpha beta-lactamase TEM-158 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID520885 | Ratio of Kcat to Km for Achromobacter xylosoxidans CIP69598 beta-lactamase OXA-114a expressed in Escherichia coli TOP10 | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID437464 | Antimicrobial activity Enterobacter cloacae ATCC 13047 by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors. |
| AID341534 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 9 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID431312 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis and structure-activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents. |
| AID531419 | Antibacterial activity against Streptococcus pneumoniae serotype 3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID558617 | Antimicrobial activity against Streptococcus pneumoniae isolate 3260 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID495738 | Kcat/Km ratio of Enterobacter cloacae AmpC relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID368500 | Ratio of Kcat to Km of Klebsiella oxytoca beta-lactamase K1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1647686 | Antibacterial activity against Streptococcus mutans ATCC 25175 assessed as reduction in microbial growth after 24 hrs by agar well diffusion assay | 2020 | Journal of natural products, 02-28, Volume: 83, Issue:2 | Isolation, Identification, and Decomposition of Antibacterial Dialkylresorcinols from a Chinese |
| AID509632 | Antimicrobial activity against Staphylococcus aureus 25 transformant carrying plasmid pKKS25 and expressing erm(T), dfrKtet(L), tet(K), tet(M), mecA and blaZ genes by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID533940 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis 411 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID171253 | Concentration of compound in rat kidney after intravenous injection of 20 mg/kg benzyl-penicillin after 40 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID776431 | Antibacterial activity against Escherichia coli ATCC 11775 at 10 mg/ml after 48 hrs by disc-diffusion method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives. |
| AID557478 | Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID495720 | Activity of Klebsiella pneumoniae Beta-lactamase TEM-26 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID431316 | Antibacterial activity against Bacillus fragilis ATCC 23745 | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis and structure-activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents. |
| AID559066 | Antibacterial activity against Streptococcus oralis by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID368490 | Ratio of Kcat to Km of Klebsiella pneumoniae SHV1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1309200 | Antibacterial activity against Staphylococcus aureus by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Four new minor brominated indole related alkaloids with antibacterial activities from Laurencia similis. |
| AID1161138 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID528524 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID524979 | Antibacterial activity against Streptococcus intermedius clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID557522 | Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID588104 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring PBP2 XXXIV pattern, MAST 51 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID1546110 | Antimicrobial activity against Proteus vulgaris | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID535352 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates by by based on parenterally dosed broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID285156 | Antimicrobial activity against Streptococcus pneumoniae ATCC 49619 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. |
| AID1287892 | Antimicrobial activity against Pseudomonas aeruginosa MTCC 741 after 24 hrs by serial two-fold broth dilution method | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline-thiazolidine-based hybrids. |
| AID619680 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 by broth microdilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives. |
| AID575101 | Antimicrobial activity against Streptococcus pneumoniae serotype 23B assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID535638 | Antimicrobial activity against Group B streptococcus serotype VI R2 harboring F395L, V405A, R433H, H438Y, and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID523003 | Antibacterial activity against uropathogenic Escherichia coli UTI89 assessed as inhibition of biofilm formation after 24 hrs by microtiterplate-based assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. |
| AID689076 | Antibacterial activity against Escherichia coli assessed as zone of inhibition at 0.05 mg by agar diffusion method | 2012 | Journal of natural products, Sep-28, Volume: 75, Issue:9 | Sinularosides A and B, bioactive 9,11-secosteroidal glycosides from the South China Sea soft coral Sinularia humilis Ofwegen. |
| AID1126516 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry, Apr-15, Volume: 22, Issue:8 | Synthesis, molecular docking and biological evaluation of metronidazole derivatives containing piperazine skeleton as potential antibacterial agents. |
| AID1072988 | Antimicrobial activity against Staphylococcus aureus Smith MB 2865 after 20 hrs by 2-fold serial broth dilution method in presence of 50 % human serum | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Isolation, structure elucidation, and biological activity of altersolanol P using Staphylococcus aureus fitness test based genome-wide screening. |
| AID573557 | Antibacterial activity against beta-lactamase producing Bacteroides thetaiotaomicron assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID324849 | Antimicrobial activity against Neisseria gonorrhoeae 91 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID558621 | Antimicrobial activity against Streptococcus pneumoniae isolate 3346 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID529335 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae serotype 14 URA5128 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID557271 | Antimicrobial activity against Streptococcus pneumoniae 2688 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID588211 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | |||
| AID666598 | Antibacterial activity against Bacillus cereus after 16 hrs by broth dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Facile synthesis, cytotoxic and antimicrobial activity studies of a new group of 6-aryl-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines. |
| AID562399 | Antimicrobial activity against Streptococcus Group F clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID557467 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae 3243 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID559511 | Antibacterial activity against Lancefield Streptococcus sp. group F assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID495730 | Activity of Acinetobacter baumannii OXA-23 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID498373 | Antimicrobial activity against wild type streptomycin-susceptible Streptococcus gordonii assessed as decrease in [14C]glucose uptake at 2 ug/ml after 60 mins by liquid scintillation counting | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | A single mutation in enzyme I of the sugar phosphotransferase system confers penicillin tolerance to Streptococcus gordonii. |
| AID587959 | Activity of Escherichia coli beta-lactamase Toho-1 N104D mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID535359 | Antimicrobial activity against Streptococcus pyogenes clinical isolates assessed as resistant isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID417433 | Antibacterial activity against Bacillus subtilis after 24 hrs by MTT method | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis and biological evaluation of novel luteolin derivatives as antibacterial agents. |
| AID1254309 | Antibacterial activity against Klebsiella pneumoniae D 11750/08 after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID587971 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 A237A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID1882849 | Binding affinity to Staphylococcus aureus ATCC 43300 50S ribosomal subunit assessed as association rate constant by surface plasmon resonance analysis | |||
| AID540181 | Antibacterial activity against Escherichia coli NCIM 2345 after 24 hrs by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and anti-tubercular and antimicrobial activities of some 2r,4c-diaryl-3-azabicyclo[3.3.1]nonan-9-one N-isonicotinoylhydrazone derivatives. |
| AID557518 | Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID666597 | Antibacterial activity against Pseudomonas aeruginosa after 16 hrs by broth dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Facile synthesis, cytotoxic and antimicrobial activity studies of a new group of 6-aryl-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines. |
| AID1428253 | Antibacterial activity against Bacillus subtilis RCMB 000109 assessed as zone of inhibition at 30 ug/ml | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold. |
| AID575084 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 6B assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID210364 | In vitro antibacterial activity against the gram-positive bacteria, penicillin resistant Streptococcus pneumoniae (4635) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7 | New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID524038 | Antibacterial activity against methicillin-, vancomycin-susceptible Staphylococcus aureus ATCC 29213 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID689074 | Antifungal activity against Microbotryum violaceum assessed as zone of inhibition at 0.05 mg by agar diffusion method | 2012 | Journal of natural products, Sep-28, Volume: 75, Issue:9 | Sinularosides A and B, bioactive 9,11-secosteroidal glycosides from the South China Sea soft coral Sinularia humilis Ofwegen. |
| AID428128 | Antimicrobial activity against wild type Streptococcus gordonii assessed as generation time at mid-logarithmic phase of growth | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory. |
| AID207836 | Minimum inhibitory concentration against aerobic organism Staphylococcus aureus strain 2868 | 1982 | Journal of medicinal chemistry, Apr, Volume: 25, Issue:4 | Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain. |
| AID1546164 | Antimicrobial activity against Staphylococcus aureus assessed as zone of inhibition at 5 mg/ml after 24 to 48 hrs by well diffusion method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID368518 | Ratio of Kcat to Km of Pseudomonas aeruginosa VIM2 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1237605 | Antibacterial activity against Bacillus subtilis ATCC6633 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID495635 | Activity of Pseudomonas luteola LAM Beta-lactamase LUT-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID1054744 | Antibacterial activity against Bacillus subtilis ATCC 6633 assessed as growth inhibition after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Schiff's base derivatives bearing nitroimidazole moiety: new class of antibacterial, anticancer agents and potential EGFR tyrosine kinase inhibitors. |
| AID529892 | Antimicrobial activity against Leptospira interrogans isolate 7 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID557515 | Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID206457 | In vitro antibacterial activity against the gram-positive bacteria, penicillin resistant Staphylococcus aureus (2672) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7 | New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID562378 | Antimicrobial activity against erythromycin-susceptible Streptococcus agalactiae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID386910 | Toxicity in sheep erythrocytes assessed as hemolysis at 100 uM after 90 mins | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Functionalized chalcones with basic functionalities have antibacterial activity against drug sensitive Staphylococcus aureus. |
| AID171267 | Concentration of compound in rat lung after intravenous injection of 20 mg/kg benzyl-penicillin after 3 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID278557 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium thermophilum ATCC 25866 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID561101 | Antibacterial activity against Pasteurella multocida BB1035 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB1005 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID437462 | Antimicrobial activity Escherichia coli ATCC 35218 by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors. |
| AID587731 | Ratio of Kcat to Km for Pseudomonas aeruginosa strain PS 297 metallo-beta-lactamase IMP18 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis using 100 uM nitrocefin | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID611681 | Antibacterial activity against Escherichia coli at 0.05 mg by agar diffusion method | 2011 | Journal of natural products, Jul-22, Volume: 74, Issue:7 | Bioactive 11,20-epoxy-3,5(16)-diene briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. |
| AID534156 | Antimicrobial activity against linezolid-resistant Enterococcus faecium 854 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID1870139 | Antibacterial activity against wild type methicillin resistant Staphylococcus aureus 5017/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID287379 | Antibacterial activity against Pseudomonas aeruginosa after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID573148 | Antibacterial activity against penicillin-nonsusceptible Streptococcus viridans assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID561251 | Antibacterial activity against Streptococcus pneumoniae assessed as intermediate isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID557498 | Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID531459 | Antibacterial activity against Streptococcus pneumoniae serotype 15A assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID263109 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USF654 by agar disk diffusion method | 2006 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8 | N-thiolated 2-oxazolidinones: a new family of antibacterial agents for methicillin-resistant Staphylococcus aureus and Bacillus anthracis. |
| AID332341 | Antimicrobial activity against Escherichia coli imp 389 after 18 hrs by microbroth dilution method | 2003 | Journal of natural products, Feb, Volume: 66, Issue:2 | Antibacterial diterpenes from Calceolaria pinifolia. |
| AID533939 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus 480 harboring G2447U in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID557475 | Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID483196 | Antibacterial activity against Escherichia coli ATCC 35218 by microbroth dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID258712 | Antibacterial activity against gram positive Staphylococcus aureus(MTCC 96) | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1 | Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents. |
| AID535760 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 00-027 expressing beta-lactamase TEM-1, MLST type ST-1921 and MAST type ST-1817 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID530509 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 3789-04 expressing pbp2x Q557E mutant and multilocus sequence type ST19 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID533877 | Antibacterial activity against amoxicillin-intermediate Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID571192 | Antibacterial activity against Neisseria gonorrhoeae harboring Asp-345a insertion in penA and porB1a genes by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID1870137 | Antibacterial activity against wild type methicillin resistant Staphylococcus aureus 4561/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID534085 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID406552 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by serial dilution method | 2008 | Bioorganic & medicinal chemistry, Jul-01, Volume: 16, Issue:13 | Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis. |
| AID406554 | Antibacterial activity against Bacillus anthracis after 24 hrs by serial dilution method | 2008 | Bioorganic & medicinal chemistry, Jul-01, Volume: 16, Issue:13 | Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis. |
| AID528701 | Antibacterial activity against Streptococcus viridans clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID395344 | Antibacterial activity against Proteus vulgaris ATCC 8427 at 10 units after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID587961 | Activity of Escherichia coli wild type beta-lactamase Toho-1 assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID325447 | Antibacterial activity against Staphylococcus aureus N315 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID561100 | Antibacterial activity against Pasteurella multocida BB1034 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB1001 bearing tetB gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID557502 | Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID436379 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT method | 2009 | European journal of medicinal chemistry, Oct, Volume: 44, Issue:10 | Synthesis, structure and structure-activity relationship analysis of 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives as potential antibacterial agents. |
| AID278548 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium bifidum BB12 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID573144 | Antibacterial activity against penicillin-susceptible Streptococcus viridans assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID356753 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus 375 after 18 hrs by microbroth dilution method | 2001 | Journal of natural products, Jul, Volume: 64, Issue:7 | Biological and mechanistic activities of xanthorrizol and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol isolated from Iostephane heterophylla. |
| AID378414 | Antimicrobial activity against Stachybotrys chartarum DSM 2144 after 24 hrs | 2006 | Journal of natural products, Aug, Volume: 69, Issue:8 | Carneic acids A and B, chemotaxonomically significant antimicrobial agents from the xylariaceous ascomycete Hypoxylon carneum. |
| AID524059 | Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP2a by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID1112106 | Antimicrobial activity against Escherichia coli by agar diffusion test | 2012 | Fitoterapia, Apr, Volume: 83, Issue:3 | Pyrenocines J-M: four new pyrenocines from the endophytic fungus, Phomopsis sp. |
| AID571181 | Antibacterial activity against Neisseria gonorrhoeae harboring GS A102S mutant gene by disk agar diffusion method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID634230 | Antibacterial activity against Streptococcus mutans ATCC 25175 assessed as growth inhibition at 0.00625 to 2.5 ug/ml after 24 hrs by microplate dilution assay | 2011 | Journal of natural products, Dec-27, Volume: 74, Issue:12 | Isoflavonoids and coumarins from Glycyrrhiza uralensis: antibacterial activity against oral pathogens and conversion of isoflavans into isoflavan-quinones during purification. |
| AID340763 | Antibacterial activity against Streptococcus gordonii with penicillin binding protein mutation | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID163929 | Minimum protective concentration against beta-lactamase of Pseudomonas aeruginosa 18S-H | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Design, synthesis, and SAR of novel carbapenem antibiotics with high stability to Xanthomonas maltophilia oxyiminocephalosporinase type II. |
| AID515293 | Antibacterial activity against Staphylococcus epidermidis MTCC 437 by broth dilution method | 2010 | European journal of medicinal chemistry, Oct, Volume: 45, Issue:10 | Stereoselective synthesis and biological evaluation of (R)-rugulactone, (6R)-((4R)-hydroxy-6-phenyl-hex-2-enyl)-5,6-dihydro-pyran-2-one and its 4S epimer. |
| AID1271946 | Antibacterial activity against Bacillus subtilis assessed as growth inhibition at 1 mg/ml by drug sensitive assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Novel skeleton compound Allomyrinanoid A and two purine alkaloids from the adult of Allomyrina dichotoma L. |
| AID206458 | In vitro antibacterial activity against the gram-positive bacteria, penicillin resistant Staphylococcus aureus (853) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7 | New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID374671 | Antimicrobial activity against wild type Escherichia coli isolate AMG1 grown as biofilms after 24 hrs by spectrophotometric method | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID451358 | Antimicrobial activity against Aspergillus fumigatus NBRC4400 after 24 hrs by broth dilution method | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. |
| AID573117 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1720710 | Antibacterial activity against Pseudomonas aeruginosa GKCW120 harboring P6 deletion mutant assessed as growth inhibition incubated for 24 hrs by micro dilution assay | 2020 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 30, Issue:16 | Short chain α-pyrones capable of potentiating penicillin G against Pseudomonas aeruginosa. |
| AID278857 | Inhibition of metabolic activity in primary human osteoblasts assessed as MTT reduction after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID495699 | Activity of Pseudomonas aeruginosa SPM-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID372897 | Antibacterial activity against Streptococcus faecalis ATCC 9790 after 24 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Apr, Volume: 44, Issue:4 | Synthesis, characterization and structure-activity relationship analysis of novel depsides as potential antibacterials. |
| AID1720709 | Antibacterial activity against Pseudomonas aeruginosa GKCW120 harboring P6 deletion mutant assessed as growth inhibition incubated for 8 hrs by micro dilution assay | 2020 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 30, Issue:16 | Short chain α-pyrones capable of potentiating penicillin G against Pseudomonas aeruginosa. |
| AID351190 | Intercompartmental clearance in preterm neonates with septicemia or invasive infections with gestational age of less than 32 weeks at 50000 U/kg, iv administered every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks. |
| AID364061 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Enamines as novel antibacterials and their structure-activity relationships. |
| AID1653059 | Antibacterial activity against Pseudomonas aeruginosa | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Isatin derivatives and their anti-bacterial activities. |
| AID558624 | Antimicrobial activity against Streptococcus pneumoniae isolate 3455 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID575144 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate NRS1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID1870127 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4717/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID1168781 | Antibacterial against Bacillus subtilis ATCC 530 after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21 | Synthesis, molecular docking and biological evaluation of coumarin derivatives containing piperazine skeleton as potential antibacterial agents. |
| AID356764 | Antimicrobial activity against Candida albicans 54 after 18 hrs by microbroth dilution method | 2001 | Journal of natural products, Jul, Volume: 64, Issue:7 | Biological and mechanistic activities of xanthorrizol and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol isolated from Iostephane heterophylla. |
| AID436380 | Antibacterial activity against Pseudomonas aeruginosa ATCC 13525 after 24 hrs by MTT method | 2009 | European journal of medicinal chemistry, Oct, Volume: 44, Issue:10 | Synthesis, structure and structure-activity relationship analysis of 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives as potential antibacterial agents. |
| AID522646 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis Ohio by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID323867 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 459 at pH 7.4 | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin. |
| AID532985 | Antibacterial activity against Escherichia coli MG1655 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID577458 | Antimicrobial activity against laboratory-derived Streptococcus pneumoniae isolate R6 harboring Thr446Ala mutant gene by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID297186 | Antibacterial activity against multidrug resistant Staphylococcus aureus 49589 | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Structure-activity relationships of phenyl-furanyl-rhodanines as inhibitors of RNA polymerase with antibacterial activity on biofilms. |
| AID395348 | Antibacterial activity against Micrococcus luteus La 2971 at 10 units after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | |||
| AID647399 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 to 24 hrs by serial broth microdilution susceptibility test | 2012 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 22, Issue:3 | Novel dendrimeric lipopeptides with antifungal activity. |
| AID1870135 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 78/CF assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID662527 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 after 18 to 20 hrs by spectrophotometry | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12 | Discovery of potent antimicrobial peptide analogs of Ixosin-B. |
| AID278532 | Antimicrobial activity against Bifidobacterium thermophilum ATCC 25866 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID573123 | Antibacterial activity against coagulase-negative and oxacillin-resistant Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID528740 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC BAA-611 harboring PBP-2X Q557E mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID562369 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group G clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID557509 | Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID519067 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae ATCC 49619 assessed as resistant strains by CLSI microdilution susceptibility testing method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Activity of the Diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America. |
| AID524063 | Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID258710 | Antibacterial activity against gram positive Bacillus subtilis MTCC 441 | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1 | Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents. |
| AID619771 | Antibacterial activity against Bacillus subtilis RCMB 000107 at 30 mg/ml after 24 hrs by agar well diffusion method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Design and synthesis of some new thiophene, thienopyrimidine and thienothiadiazine derivatives of antipyrine as potential antimicrobial agents. |
| AID368510 | Activity of Serratia marcescens SME3 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID609854 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 assessed as growth inhibition after 18 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Unprecedented C-2 arylation of indole with diazonium salts: Syntheses of 2,3-disubstituted indoles and their antimicrobial activity. |
| AID571188 | Antibacterial activity against Neisseria gonorrhoeae harboring wild-type penA and DA G101D mutant genes by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID324836 | Antimicrobial activity against Neisseria gonorrhoeae 188 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID1254312 | Antibacterial activity against Pseudomonas aeruginosa CCM 1961 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID666781 | Antifungal activity against Septoria tritici at 0.05 mg by agar diffusion test | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13 | Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. |
| AID1161140 | Antimicrobial activity against Staphylococcus epidermidis after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID278524 | Antimicrobial activity against Bifidobacterium bifidum BB12 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID332340 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 310 after 18 hrs by microbroth dilution method | 2003 | Journal of natural products, Feb, Volume: 66, Issue:2 | Antibacterial diterpenes from Calceolaria pinifolia. |
| AID1638899 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 measured after 18 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action. |
| AID418562 | Antibacterial activity against Bacillus cereus ATCC 11778 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents. |
| AID557468 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae 3665 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID520386 | Activity at Pseudomonas aeruginosa COL-1 metallo-beta lactamase VIM-2 by spectrometry | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID586081 | Antimicrobial activity against multidrug-resistant Neisseria gonorrhoeae isolates assessed as resistant isolates by disk susceptibility test | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characteristics and dissemination of mosaic penicillin-binding protein 2-harboring multidrug-resistant Neisseria gonorrhoeae isolates with reduced cephalosporin susceptibility in northern Taiwan. |
| AID278523 | Antimicrobial activity against Bifidobacterium bifidum ATCC 15696 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1348090 | Antimicrobial activity against Escherichia coli ATCC 25922 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID1126517 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry, Apr-15, Volume: 22, Issue:8 | Synthesis, molecular docking and biological evaluation of metronidazole derivatives containing piperazine skeleton as potential antibacterial agents. |
| AID438298 | Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2X preincubated for 4 hrs before addition of substrate (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19 | Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening. |
| AID524878 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA and ponA mutant gene assessed as incidence of resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID559707 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus P1369 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID1546643 | Antibacterial activity against Escherichia coli MTCC 443 assessed as diameter of zone of inhibition at 200 ug/ml after 24 hrs by agar well diffusion method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1 | Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents. |
| AID658947 | Antibacterial activity against Pseudomonas aeruginosa 155250A at 100 mg/ml after 24 hrs by agar-well diffusion technique | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | 2-Aminothiophenes as building blocks in heterocyclic synthesis: synthesis and antimicrobial evaluation of a new class of pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and pyridin-2-one derivatives. |
| AID263104 | Antibacterial activity against Staphylococcus aureus 849 ATCC 25923 by agar disk diffusion method | 2006 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8 | N-thiolated 2-oxazolidinones: a new family of antibacterial agents for methicillin-resistant Staphylococcus aureus and Bacillus anthracis. |
| AID529320 | Antibacterial activity against Streptococcus pneumoniae serotype 19F URA4087 harboring mutant PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID258711 | Antibacterial activity against gram positive Bacillus sphaericus (MTCC 11) | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1 | Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents. |
| AID557482 | Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID569255 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. |
| AID531461 | Antibacterial activity against Streptococcus pneumoniae serotype 22 assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID660263 | Ratio of MIC for wild type Salmonella typhimurium SH5014 to MIC for Salmonella typhimurium SH7616 harboring missense mutation in acrA/acrB gene by two-fold serial dilution method | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID543277 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID1546171 | Antimicrobial activity against Bacillus thuringiensis | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID529325 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae serotype 23F URA5391 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID1870134 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4788/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID773425 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700698 by microdilution technique | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20 | The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds. |
| AID557508 | Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID511535 | Antimicrobial activity against Streptococcus uberis ATCC 8749 harboring PAP1A A227T/G386R, PBP2B N366I/T402I and PBP2X E381K/D524A/Q554E mutation after 37 passages assessed as inhibition of visible growth broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID533932 | Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus NRS121 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID524052 | Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID263112 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USF657 by agar disk diffusion method | 2006 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8 | N-thiolated 2-oxazolidinones: a new family of antibacterial agents for methicillin-resistant Staphylococcus aureus and Bacillus anthracis. |
| AID279185 | Inhibition of Enterobacter cloacae S3 isolate beta lactamase LAP1 expressed in Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID417434 | Antibacterial activity against Staphylococcus aureus after 24 hrs by MTT method | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis and biological evaluation of novel luteolin derivatives as antibacterial agents. |
| AID554870 | Antimicrobial activity against Streptococcus pneumoniae serotype 23F ST 3250 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID546429 | Activity at Pseudomonas aeruginosa PDC-5 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID559499 | Antibacterial activity against Listeria monocytogenes assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID340851 | Increase in pbp1A gene expression in penicillin-resistant Streptococcus gordonii with penicillin binding protein PR1_2 evolved mutation at 1/8 times MIC assessed as relative luciferase units relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID171259 | Concentration of compound in rat liver after intravenous injection of 20 mg/kg benzyl-penicillin after 20 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID278545 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium animalis ATCC 27536 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID503231 | Ratio of MIC for penicillin-resistant Streptococcus pneumoniae 5204 to MIC for penicillin-sensitive Streptococcus pneumoniae R6 | 2007 | Nature chemical biology, Sep, Volume: 3, Issue:9 | Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. |
| AID1245116 | Antimicrobial activity against Escherichia coli ATCC 35218 after 18 hrs by broth microdilution method | 2015 | Bioorganic & medicinal chemistry, Sep-15, Volume: 23, Issue:18 | Design, synthesis and molecular docking of salicylic acid derivatives containing metronidazole as a new class of antimicrobial agents. |
| AID529317 | Antibacterial activity against Streptococcus pneumoniae URA2543 harboring mutant PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID568433 | Antimicrobial activity against Bacillus subtilis MTCC 441 after 24 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Stereoselective first total synthesis, confirmation of the absolute configuration and bioevaluation of botryolide-E. |
| AID1180450 | Antimicrobial activity against Staphylococcus epidermidis H 6966/08 after 48 hrs by microdilution method | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates. |
| AID567283 | Ratio of Kcat to Km for Acinetobacter baumannii ADC-33 beta-lactamase to Kcat to Km for Acinetobacter baumannii ADC-11 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID1168783 | Antibacterial against Escherichia coli ATCC 25922 after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21 | Synthesis, molecular docking and biological evaluation of coumarin derivatives containing piperazine skeleton as potential antibacterial agents. |
| AID577456 | Inhibition of Bocillin FL binding to PBP2b in Streptococcus pneumoniae isolate 8819 harboring E333G, I361L, E369D, S412P, N422Y, T426K, Q427L, Q438E, L455I, S473T, E476G, S480A, T489A, N538D, D561E, Q564K, and D625G mutant genes | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID557210 | Antibacterial activity against Beta-lactamase-negative Neisseria meningitidis assessed as percent intermediate isolates by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. |
| AID582965 | Antimicrobial activity against Yersinia enterocolitica Biovar 1B 8081 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID269453 | Antibacterial activity against Escherichia coli ATCC 33475 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID1437931 | Bactericidal activity against Streptococcus mutans ATCC 25175 after 24 hrs | 2017 | Journal of natural products, 01-27, Volume: 80, Issue:1 | Dibenzofurans and Pseudodepsidones from the Lichen Stereocaulon paschale Collected in Northern Quebec. |
| AID395343 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 10 units after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID533879 | Antibacterial activity against amoxicillin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID451355 | Antimicrobial activity against Candida albicans NBRC1060 after 24 hrs by broth dilution method | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. |
| AID467613 | Volume of distribution at steady state in human | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. |
| AID394486 | Ratio of Kcat to Km for Escherichia coli beta-lactamase ACC4 by UV spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID1237606 | Antibacterial activity against Escherichia coli ATCC25922 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID573582 | Antibacterial activity against beta-lactamase producing Bacteroides caccae assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID519982 | Activity of Klebsiella pneumoniae Beta-Lactamase SHV-55 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID571190 | Antibacterial activity against Neisseria gonorrhoeae harboring wild-type penA and GS A102S mutant genes by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID511448 | Antimicrobial activity against Streptococcus uberis isolate ALP8092 harboring PAP1A G386R and PBP2X E381K/Q554E mutation assessed as inhibition of visible growth after 24 hrs by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID1755805 | Antibacterial activity against Escherichia coli ATCC 35218 incubated for 24 hrs by two fold serial dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID341343 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 3 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID558334 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1093 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID466789 | Antibacterial activity against Staphylococcus aureus ATCC 6538 | 2010 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6 | Design and synthesis of novel deoxybenzoin derivatives as FabH inhibitors and anti-inflammatory agents. |
| AID575948 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae assessed as resistant isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. |
| AID490135 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents. |
| AID205985 | In vitro Minimum inhibitory concentration against Staphylococcus aureus ATCC 6538P (penicillin G sensitive) | 1981 | Journal of medicinal chemistry, Oct, Volume: 24, Issue:10 | Synthesis and evaluation of ureido- and vinylureidopenicillins as inhibitors of intraruminal lactic acid production. |
| AID1366163 | Antibacterial activity against Escherichia coli by agar dilution method | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22 | Antibacterial constituents of the plant family Amaryllidaceae. |
| AID588108 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB G120K, A121D mutant gene, PBP1 L421P mutant gene, PBP2 XXXVIII pattern, insertion of nucleotide T from mtrA promoter, MAST 3158 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID577442 | Antimicrobial activity against Staphylococcus aureus USA300 isolate harboring pSK41 plasmid assessed resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Emergence of resistance among USA300 methicillin-resistant Staphylococcus aureus isolates causing invasive disease in the United States. |
| AID171247 | Concentration of compound in rat brain after intravenous injection of 20 mg/kg benzyl-penicillin after 60 min; Below detection limit. | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID431309 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis and structure-activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents. |
| AID1546646 | Antibacterial activity against Staphylococcus aureus MTCC 96 assessed as reduction in microbial growth after 24 hrs by CLSI based microdilution method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1 | Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents. |
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | |||
| AID511444 | Antimicrobial activity against Streptococcus uberis ATCC 8749 harboring PAP1A A227T/G386R, PBP2B N366I/T402I and PBP2X E381K/D524A/Q554E mutation after 28 passages assessed as inhibition of visible growth broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID524645 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA and ponA mutant gene assessed as incidence of susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID171108 | Concentration of compound in rat blood after intravenous injection of 20 mg/kg benzyl-penicillin after 10 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID431314 | Antibacterial activity against Bacillus subtilis ATCC 23857 | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis and structure-activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents. |
| AID495733 | Kcat/Km ratio of Escherichia coli CTX-M-15 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID437459 | Antimicrobial activity Bacillus subtilis ATCC 6633 by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors. |
| AID437463 | Antimicrobial activity Pseudomonas aeruginosa ATCC 13525 by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors. |
| AID528522 | Antimicrobial activity against Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID171109 | Concentration of compound in rat blood after intravenous injection of 20 mg/kg benzyl-penicillin after 20 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID681114 | TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in SKPT cells | 2005 | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jan, Volume: 59, Issue:1 | Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. |
| AID560705 | Inhibition of Escherichia coli MC4100 Beta-Lactamase CMY-30 using cephalothin as reporter substrate | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID1759749 | Binding affinity to Staphylococcus aureus ATCC 43300 50S ribosome assessed as dissociation constant by SPR analysis | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Design, synthesis and biological evaluation of novel pleuromutilin derivatives as potent anti-MRSA agents targeting the 50S ribosome. |
| AID776442 | Antibacterial activity against Staphylococcus aureus ATCC 12600 after 24 hrs by microdilution technique | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives. |
| AID585180 | Activity of Beta-lactamase GES-13 K104, N170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID575418 | Antimicrobial activity against anrB-deficient Listeria monocytogenes EGD-e assessed as growth inhibition after 16 hrs by broth dilution method relative to wild type | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics. |
| AID278527 | Antimicrobial activity against Bifidobacterium longum ATCC 15707 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID96241 | In Vitro minimal inhibitory concentration against Klebsiella pneumoniae (NCTC 418) | 1998 | Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24 | Syntheses of new isodethiaazacephems as potent antibacterial agents. |
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | |||
| AID569256 | Antimycobacterial activity against Mycobacterium bovis BCG str. Tokyo 172 | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. |
| AID531444 | Antibacterial activity against Streptococcus pneumoniae serotype 19A assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID529455 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae serotype 24F URA5450 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID1720708 | Antibacterial activity against Pseudomonas aeruginosa PAO1 assessed as growth inhibition by micro dilution assay | 2020 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 30, Issue:16 | Short chain α-pyrones capable of potentiating penicillin G against Pseudomonas aeruginosa. |
| AID569338 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID420257 | Inhibition of Enterococcus faecium PBP5fm assessed as residual activity at 100 uM after 16 hrs | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Large ring 1,3-bridged 2-azetidinones: experimental and theoretical studies. |
| AID529903 | Antimicrobial activity against Leptospira kirschneri serovar Grippotyphosa isolate 13 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID524033 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 1394 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID1126514 | Antibacterial activity against Bacillus subtilis ATCC 530 after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry, Apr-15, Volume: 22, Issue:8 | Synthesis, molecular docking and biological evaluation of metronidazole derivatives containing piperazine skeleton as potential antibacterial agents. |
| AID374676 | Antimicrobial activity against Escherichia coli AMG1 isolate 24 hrs flow cell-generated biofilms using BacLight staining by CSLM | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID1237611 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC425055 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID287374 | Antibacterial activity against Bacillus cereus after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID531422 | Antibacterial activity against Streptococcus pneumoniae serotype 23A by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID529332 | Antibacterial activity against penicillin-cefotaxime- ceftriaxone-resistant Streptococcus pneumoniae URA6056 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID394489 | Activity of Hafnia alvei beta-lactamase ACC-1 | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID420255 | Inhibition of Actinomadura R39 DD-peptidase assessed as residual activity at 100 uM after 16 hrs | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Large ring 1,3-bridged 2-azetidinones: experimental and theoretical studies. |
| AID558628 | Antimicrobial activity against Streptococcus pneumoniae isolate 3681 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID531454 | Antibacterial activity against Streptococcus pneumoniae serotype 6A/C assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID28949 | Partition coefficient (logP) | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. Synthesis and properties of some dihydropyridine and dihydroiosquinoline derivatives of benzylpenicillin. |
| AID542629 | Antimicrobial activity against streptomycin-resistant Streptococcus pneumoniae R6 harboring PBP2x T338G mutant gene, Janus disruption at PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID773426 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC BAA-39 by microdilution technique | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20 | The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds. |
| AID295107 | Antibacterial activity against Proteus vulgaris ATCC 8427 at 10 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID592502 | Antibacterial activity against Legionella pneumophila Corby by microtiter plate assay | 2011 | Journal of natural products, Mar-25, Volume: 74, Issue:3 | Diversonol and blennolide derivatives from the endophytic fungus Microdiplodia sp.: absolute configuration of diversonol. |
| AID341535 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 33 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID540183 | Antibacterial activity against Staphylococcus aureus NCIM 2492 after 24 hrs by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and anti-tubercular and antimicrobial activities of some 2r,4c-diaryl-3-azabicyclo[3.3.1]nonan-9-one N-isonicotinoylhydrazone derivatives. |
| AID207806 | Compound was evaluated for the antibacterial activity against Staphylococcus aureus with the strain 209P | 1984 | Journal of medicinal chemistry, Mar, Volume: 27, Issue:3 | Dependence of beta-lactamase stability on substructures within beta-lactam antibiotics. |
| AID562756 | Ratio of Kcat to Km for Klebsiella pneumoniae AH24-270 CTX-M-71 beta-lactamase | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID368523 | Activity of Enterobacter cloacae 4080 AmpC (P99) assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID665398 | Antibacterial activity against Pseudomonas aeruginosa MTCC 7952 after 24 hrs by serial dilution technique | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Synthesis, characterization, antimicrobial activities and QSAR studies of some 10a-phenylbenzo[b]indeno[1,2-e][1,4]thiazin-11(10aH)-ones. |
| AID429082 | Antibacterial activity against penicillin-intermediate resistant Neisseria meningitidis clinical isolates harbouring altered penA gene after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Combined real-time PCR and pyrosequencing strategy for objective, sensitive, specific, and high-throughput identification of reduced susceptibility to penicillins in Neisseria meningitidis. |
| AID569341 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis ATCC 12228 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID524040 | Antibacterial activity against methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID495742 | Kcat/Km ratio of Pseudomonas aeruginosa VIM-2 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID374362 | Ratio of Kcat to Km of Aeromonas caviae A324R metallo-beta-lactamase IMP-19 expressed in Escherichia coli DH5alpha by computerized microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France. |
| AID542623 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338P mutant gene, disruption at PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID1287894 | Antimicrobial activity against Chromobacterium violaceum MTCC 2625 after 24 hrs by serial two-fold broth dilution method | 2016 | European journal of medicinal chemistry, May-04, Volume: 113 | Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline-thiazolidine-based hybrids. |
| AID495709 | Kcat/Km ratio of Pseudomonas aeruginosa OXA-10 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID678786 | TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes | 1999 | The Journal of pharmacology and experimental therapeutics, Aug, Volume: 290, Issue:2 | The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. |
| AID498372 | Antimicrobial activity against penicillin- and streptomycin-resistant Streptococcus gordonii Tol1 harboring Tol1 mutation in ptsI after 24 hrs by macrodilution assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | A single mutation in enzyme I of the sugar phosphotransferase system confers penicillin tolerance to Streptococcus gordonii. |
| AID529330 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae serotype 23F ATCC 51916 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID572286 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus NB01021 infected in sc dosed BALB/c mouse administered 0, 4, 23 hrs post infection | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID93879 | Minimum inhibitory concentration against aerobic organism Klebsiella pneumoniae strain 2882 | 1982 | Journal of medicinal chemistry, Apr, Volume: 25, Issue:4 | Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain. |
| AID368524 | Activity of Enterobacter cloacae 4080 AmpC (P99) assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID495741 | Kcat/Km ratio of Serratia marcescens SME-3 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID557510 | Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID524198 | Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID495715 | Kcat/Km ratio of Acinetobacter baumannii OXA-23 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID565812 | Antimicrobial activity against Neisseria meningitidis assessed as resistant isolate by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Determination of CEM-101 activity tested against clinical isolates of Neisseria meningitidis from a worldwide collection. |
| AID1279020 | Antibacterial activity against ESBL-positive Klebsiella pneumoniae J 14368/08 after 48 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID368539 | Activity of Pseudomonas aeruginosa 4352 AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID522388 | Activity of Aeromonas enteropelogenes Beta-lactamase TRU1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID324838 | Antimicrobial activity against Neisseria gonorrhoeae 253 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID1279012 | Antibacterial activity against Staphylococcus epidermidis H 6966/08 after 48 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID368536 | Activity of Providencia stuartii AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID523004 | Antibacterial activity against uropathogenic Escherichia coli UTI89 assessed as degradation of preexisting biofilm after 24 hrs by microscopy | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. |
| AID340767 | Induction of pbp2A gene expression in wild type penicillin-susceptible Streptococcus gordonii assessed as relative luciferase units relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID529579 | Ratio of Kcat to Km for Legionella gormanii ATCC 33297T beta-Lactamase FEZ-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID1243285 | Antimicrobial activity against levofloxacin-resistant Staphylococcus aureus clinical isolates by standard broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Synthesis and biological evaluation of levofloxacin core-based derivatives with potent antibacterial activity against resistant Gram-positive pathogens. |
| AID503225 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 4790 by microscopy | 2007 | Nature chemical biology, Sep, Volume: 3, Issue:9 | Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. |
| AID530523 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 8607 expressing multiple copies of wild-type pbp2x by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID301808 | Antibacterial activity against Bacillus anthracis AMES | 2007 | Bioorganic & medicinal chemistry, Dec-01, Volume: 15, Issue:23 | Direct diazo-transfer reaction on beta-lactam: synthesis and preliminary biological activities of 6-triazolylpenicillanic acids. |
| AID447056 | Antibacterial activity against Bacillus cereus ATCC 7064 at 10 IU after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | |||
| AID508308 | Inhibition of PBP6 in wild type Enterococcus faecium D63 membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID525550 | Antimicrobial activity against ampicillin resistant serotype-e Haemophilus influenzae isolate BB1053 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID559702 | Antimicrobial activity against Staphylococcus aureus AB94004 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID404304 | Effect on human MRP2-mediated estradiol-17-beta-glucuronide transport in Sf9 cells inverted membrane vesicles relative to control | 2008 | Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11 | Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). |
| AID679489 | TP_TRANSPORTER: inhibition of PAH uptake in Oat1-expressing LLC-PK1 cells | 2002 | The Journal of pharmacology and experimental therapeutics, Mar, Volume: 300, Issue:3 | Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. |
| AID530502 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype IA isolate 7490-03 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID660265 | Antimicrobial activity against wild type Escherichia coli expressing AcrAB-TolC efflux pump | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID428133 | Antimicrobial activity against wild type Streptococcus gordonii assessed as logarithmic reduction in viability at stationary phase of growth after 70 hrs | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory. |
| AID545512 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC BAA-1680 by microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | The synthesis of phenylalanine-derived C5-substituted rhodanines and their activity against selected methicillin-resistant Staphylococcus aureus (MRSA) strains. |
| AID322494 | Cmax in human term neonates at 15 mg/kg, im administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID558538 | Antibacterial activity against bla-positive and beta-lactamase-weakly positive Campylobacter coli isolate P1627 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID585182 | Ratio of Kcat to Km for Beta-lactamase GES-7 K104, G170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID770974 | Antibacterial activity against Bacillus subtilis MTCC 441 by broth dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Demonic axe-like conjugated alkynes in combating microbes. |
| AID528531 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B60 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID301807 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 | 2007 | Bioorganic & medicinal chemistry, Dec-01, Volume: 15, Issue:23 | Direct diazo-transfer reaction on beta-lactam: synthesis and preliminary biological activities of 6-triazolylpenicillanic acids. |
| AID368502 | Activity of Klebsiella pneumoniae TEM26 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID368491 | Ratio of Kcat to Km of Klebsiella pneumoniae SHV1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID325448 | Antibacterial activity against Staphylococcus aureus Mu50 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID495704 | Kcat/Km ratio of Klebsiella oxytoca Beta-lactamase K1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID558534 | Antibacterial activity against bla gene-positive and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P1699 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID562612 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID557500 | Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID519634 | Ratio of Kcat to Km for beta-lactamase FUS1 assessed as compound hydrolysis by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID1254306 | Antibacterial activity against Escherichia coli CCM4517 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID625291 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID529576 | Ratio of Kcat to Km for Erwinia carotovora subsp. atroseptica DSM 30184 beta-Lactamase CAR-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID715626 | Antibacterial activity against Escherichia coli MTCC 42 after 24 hrs by serial dilution method | 2012 | European journal of medicinal chemistry, Nov, Volume: 57 | Synthesis, characterization, biological evaluation and QSAR studies of 11-p-substituted phenyl-12-phenyl-11a,12-dihydro-11H-indeno[2,1-c][1,5]benzothiazepines as potential antimicrobial agents. |
| AID315976 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 24 hrs by broth dilution MIC assay | 2008 | Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5 | Glyconanobiotics: Novel carbohydrated nanoparticle antibiotics for MRSA and Bacillus anthracis. |
| AID521351 | Antimicrobial activity against Streptococcus pneumoniae isolate k-585 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID322503 | Clearance in human adults at 600 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID535768 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 08-046 expressing beta-lactamase TEM-1, MLST type ST-1584 and MAST type ST-1478 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID530514 | Antimicrobial activity against group B Streptococcus sp. 'group B' isolate 4214-03 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID625287 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID368732 | Ratio of Kcat to Km of Pseudomonas aeruginosa AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID554875 | Antimicrobial activity against Streptococcus pneumoniae serotype 18C ST 496 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID522659 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis 003BS by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID531317 | Activity of Escherichia coli beta-lactamase VIM-1 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID573551 | Antibacterial activity against Bacteroides fragilis assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID529661 | Activity of Pseudomonas aeruginosa 9551 beta-lactamase VIM-15 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID558607 | Antimicrobial activity against Streptococcus pneumoniae isolate 1384 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID422495 | Antimicrobial activity against Escherichia coli BL21 (DE3) harboring pAT514 by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID575078 | Antimicrobial activity against Streptococcus pneumoniae serotype 35B assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID539690 | Antifungal activity against Bacillus subtilis MTCC 441 by broth dilution method | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | Indium(III) chloride catalyzed three-component coupling reaction: a novel synthesis of 2-substituted aryl(indolyl)kojic acid derivatives as potent antifungal and antibacterial agents. |
| AID524062 | Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID554861 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 2916 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID1354715 | Antimicrobial activity against Pasteurella multocida subsp. multocida ATCC 43137 after 24 hrs by serial dilution method | |||
| AID715624 | Antibacterial activity against Bacillus subtilis MTCC 441 after 24 hrs by serial dilution method | 2012 | European journal of medicinal chemistry, Nov, Volume: 57 | Synthesis, characterization, biological evaluation and QSAR studies of 11-p-substituted phenyl-12-phenyl-11a,12-dihydro-11H-indeno[2,1-c][1,5]benzothiazepines as potential antimicrobial agents. |
| AID341341 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 2 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID561102 | Antibacterial activity against Pasteurella multocida BB1036 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB1005 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID680321 | TP_TRANSPORTER: uptake in OATP-B-expressing HEK293 cells | 2000 | Biochemical and biophysical research communications, Jun-24, Volume: 273, Issue:1 | Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. |
| AID574169 | Antibacterial activity against Escherichia coli MG1655 harboring plasmid pBR322 carrying blaTEM-1 and tetA(C) genes grown as planktonic cells after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Induction of multidrug resistance mechanism in Escherichia coli biofilms by interplay between tetracycline and ampicillin resistance genes. |
| AID658949 | Antibacterial activity against Bacillus subtilis 154921 at 100 mg/ml after 24 hrs by agar-well diffusion technique | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | 2-Aminothiophenes as building blocks in heterocyclic synthesis: synthesis and antimicrobial evaluation of a new class of pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and pyridin-2-one derivatives. |
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | |||
| AID368508 | Ratio of Kcat to Km of Escherichia coli KPC2 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID563973 | Ratio of Kcat to Km for Klebsiella pneumoniae 05-560 beta-lactamase NDM-1 | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID773422 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ST239 HS770 by microdilution technique | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20 | The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds. |
| AID375915 | Antibacterial activity against methicillin-resistan Staphylococcus epidermidis ATCC 51625 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents. |
| AID679396 | TP_TRANSPORTER: inhibition of PAH uptake (PCG: 200 uM) in OAT1-expressing HeLa cells | 1999 | The American journal of physiology, 02, Volume: 276, Issue:2 | Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. |
| AID1347489 | Antibacterial activity against Serratia marcescens assessed as zone of inhibition after 24 to 48 hrs by well diffusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations. |
| AID431317 | Antibacterial activity against Clostridium perfringens ATCC 10388 | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis and structure-activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents. |
| AID681372 | TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells | 2002 | The Journal of pharmacology and experimental therapeutics, Aug, Volume: 302, Issue:2 | Characterization of methotrexate transport and its drug interactions with human organic anion transporters. |
| AID557270 | Antimicrobial activity against Streptococcus pneumoniae 1564 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID447055 | Antibacterial activity against Klebsiella pneumoniae UC57 at 10 IU after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID418559 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents. |
| AID681426 | TP_TRANSPORTER: inhibition of E1S uptake (E1S: 40 uM, PCG: 1000 uM) in Xenopus laevis oocytes | 1999 | The Journal of biological chemistry, May-07, Volume: 274, Issue:19 | Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. |
| AID528533 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B502 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID278563 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum ATCC 15707 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID529901 | Antimicrobial activity against Leptospira interrogans serovar Icterohaemorrhagiae isolate 10 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID1870123 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4740/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID681049 | TP_TRANSPORTER: inhibition of E1S uptake (E1S: 0.05 uM, PCG: 5 uM) in Xenopus laevis oocytes | 2001 | Molecular pharmacology, May, Volume: 59, Issue:5 | Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. |
| AID368527 | Activity of Enterobacter cloacae 908R AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID558612 | Antimicrobial activity against Streptococcus pneumoniae isolate 2617 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID524668 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA and ponA mutant gene assessed as percentage intermediate isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID381178 | Antibacterial activity against Pseudomonas aeruginosa after 24 to 72 hrs by disk diffusion method | 1999 | Journal of natural products, Sep, Volume: 62, Issue:9 | Antimicrobial and antitumor activities of mycosporulone. |
| AID562341 | Ratio of Kcat to Km for Chryseobacterium meningosepticum CCUG 4310 beta-lactamase BlaB1 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID368310 | Activity of Escherichia coli TEM1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID562400 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group F clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID557474 | Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID558606 | Antimicrobial activity against Streptococcus pneumoniae isolate 1147 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID531451 | Antibacterial activity against Streptococcus pneumoniae serotype 33 assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID278536 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium bifidum BB12 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID529318 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae serotype 14 URA4933 harboring mutant PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID278859 | Inhibition of metabolic activity in MG63 cells assessed as MTT reduction after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID278528 | Antimicrobial activity against Bifidobacterium longum ATCC 15708 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1565591 | Antibacterial activity against Escherichia coli ATCC 43837 after 18 hrs by CLSI based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity. |
| AID533943 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis 414 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID562401 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group F clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID395400 | Antibacterial activity against Klebsiella pneumoniae TCC 109 at 20 ug after 24 hrs by cup diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis of new series of 5,6-dihydro-4H-1,2-oxazines via hetero Diels-Alder reaction and evaluation of antimicrobial activity. |
| AID519748 | Ratio of Kcat to Km for Klebsiella pneumoniae Beta-Lactamase SHV-1 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID558619 | Antimicrobial activity against Streptococcus pneumoniae isolate 3275 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1180445 | Antimicrobial activity against Staphylococcus aureus CCM 4516/08 after 24 hrs by microdilution method | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates. |
| AID558615 | Antimicrobial activity against Streptococcus pneumoniae isolate 2874 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID322512 | Effect on glomerular filtration in human very low birth weight preterm neonates urine assessed as creatinine excretion at 30 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID535349 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as susceptible isolates by by based on po dosed broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID528726 | Antibacterial activity against Streptococcus mitis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID554872 | Antimicrobial activity against Streptococcus pneumoniae serotype 6B ST 3246 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID528525 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B6 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID495913 | Ratio of Kcat to Km for beta-lactamase VIM-19 expressed in Escherichia coli TOP10 by spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID1546642 | Antibacterial activity against Bacillus subtilis MTCC 441 assessed as diameter of zone of inhibition at 200 ug/ml after 24 hrs by agar well diffusion method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1 | Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents. |
| AID546433 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-5 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID493658 | Antimicrobial activity against Enterobacter cloacae ATCC 13047 by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors. |
| AID1271948 | Antibacterial activity against Staphylococcus aureus assessed as growth inhibition at 1 mg/ml by drug sensitive assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Novel skeleton compound Allomyrinanoid A and two purine alkaloids from the adult of Allomyrina dichotoma L. |
| AID543279 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp1a and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID406549 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition zone diameter at 20 ug after 24 hrs by Kirby-Bauer test | 2008 | Bioorganic & medicinal chemistry, Jul-01, Volume: 16, Issue:13 | Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis. |
| AID522652 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis 02AS-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID531418 | Antibacterial activity against Streptococcus pneumoniae serotype 6A/C by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID575415 | Antimicrobial activity against anrB-deficient Listeria monocytogenes EGD-e at 5 ug after 16 hrs by disk diffusion assay | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics. |
| AID529658 | Ratio of Kcat to Km for Pseudomonas aeruginosa 166301 beta-lactamase VIM-16 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID508303 | Inhibition of PBP2 in wild type Enterococcus faecium D63 membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID398239 | Antimicrobial activity against Escherichia coli 442 after 18 hrs by twofold serial microbroth dilution method | 2003 | Journal of natural products, Dec, Volume: 66, Issue:12 | A novel antibacterial iridoid and triterpene from Caiophora coronata. |
| AID278676 | Antibacterial activity against Enterococcus faecalis isolate 5742 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID573596 | Antibacterial activity against Fusobacterium mortiferum assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID561107 | Antibacterial activity against Pasteurella multocida BB1041 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID495740 | Kcat/Km ratio of Klebsiella pneumoniae KPC-2 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID278553 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum ATCC 15708 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID295101 | Antibacterial activity against Klebsiella pneumoniae UC57 at 10 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID278683 | Antibacterial activity against Enterococcus faecalis isolate 5745 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID1129596 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Apr-09, Volume: 76 | Design, synthesis and molecular modeling of pyrazole-quinoline-pyridine hybrids as a new class of antimicrobial and anticancer agents. |
| AID1765580 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID315975 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by broth dilution MIC assay | 2008 | Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5 | Glyconanobiotics: Novel carbohydrated nanoparticle antibiotics for MRSA and Bacillus anthracis. |
| AID524876 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA and mtrR mutant gene assessed as incidence of resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID341340 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 5 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID431318 | Antifungal activity against Candida albicans ATCC 90028 | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis and structure-activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents. |
| AID542612 | Antimicrobial activity against Streptococcus pneumoniae R6 after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID520398 | Antibacterial activity against mef-positive Streptococcus pneumoniae isolates assessed as resistance incidence by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID1237610 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC523512 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID1320835 | Activity of native signal containing Klebsiella pneumoniae OXA-48 by Michaelis-Menten kinetics assay | 2016 | Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11 | Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening. |
| AID1072985 | Antimicrobial activity against Bacillus subtilis MB 964 after 20 hrs by 2-fold serial broth dilution method | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Isolation, structure elucidation, and biological activity of altersolanol P using Staphylococcus aureus fitness test based genome-wide screening. |
| AID494349 | Antibacterial activity against Pseudomonas aeruginosa by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis, characterization and antimicrobial studies of 2-(4-methoxy-phenyl)-5-methyl-4-(2-arylsulfanyl-ethyl)-2,4-dihydro-[1,2,4] triazolo-3-ones and their corresponding sulfones. |
| AID558330 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P316 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID773428 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 34404 by microdilution technique | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20 | The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds. |
| AID322499 | Cmin in human adults at 600 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID558331 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P338 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID322508 | AUC (0 to 12) in human very low birth weight preterm neonates at 28 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID562754 | Activity of Klebsiella pneumoniae AH24-270 CTX-M-71 beta-lactamase | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID374680 | Antimicrobial activity against wild type Escherichia coli K-12 flow cell-generated 24 hrs biofilms at 350 ug/ml after 1 hr using BacLight staining by CSLM | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID428135 | Antimicrobial activity against penicillin-resistant Streptococcus gordonii PR1_2evolved mutant assessed as logarithmic reduction in viability at stationary phase of growth after 70 hrs | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory. |
| AID528710 | Antibacterial activity against penicillin intermediate Streptococcus pneumoniae clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID519630 | Antimicrobial activity against Escherichia coli JM83 harboring beta-lactamase OXA-63 after 3 days by Etest | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID341533 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 81 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID535358 | Antimicrobial activity against Streptococcus pyogenes clinical isolates assessed as susceptible isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID374673 | Antimicrobial activity against wild type Escherichia coli isolate AMG1 grown as planktonic cells after 24 hrs by spectrophotometric method | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID558602 | Antimicrobial activity against Streptococcus pneumoniae isolate 33 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID171255 | Concentration of compound in rat kidney after intravenous injection of 20 mg/kg benzyl-penicillin after 60 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID515291 | Antibacterial activity against Bacillus subtilis MTCC 441 by broth dilution method | 2010 | European journal of medicinal chemistry, Oct, Volume: 45, Issue:10 | Stereoselective synthesis and biological evaluation of (R)-rugulactone, (6R)-((4R)-hydroxy-6-phenyl-hex-2-enyl)-5,6-dihydro-pyran-2-one and its 4S epimer. |
| AID1482267 | Antibacterial activity against Escherichia coli MG1655 measured every 15 mins for 12 hrs | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | Prediction of Antibiotic Interactions Using Descriptors Derived from Molecular Structure. |
| AID324844 | Antimicrobial activity against Neisseria gonorrhoeae 67 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID575143 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate NRS70 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID562410 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group G clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID324840 | Antimicrobial activity against Neisseria gonorrhoeae 196 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID609859 | Antimicrobial activity against Candida albicans ATCC 26555 assessed as growth inhibition after 18 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Unprecedented C-2 arylation of indole with diazonium salts: Syntheses of 2,3-disubstituted indoles and their antimicrobial activity. |
| AID1236038 | Antibacterial activity against Staphylococcus aureus assessed as growth inhibition at 200 ug/ml after 24 hrs by paper disk diffusion method | 2015 | Journal of natural products, Aug-28, Volume: 78, Issue:8 | Bisabolane-Type Sesquiterpenoids from the Whole Plant of Parasenecio rubescens. |
| AID558622 | Antimicrobial activity against Streptococcus pneumoniae isolate 3374 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID418556 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents. |
| AID535637 | Antimicrobial activity against Group B streptococcus serotype Ib R3 harboring Q557E, A400V mutations in PBP 2X and T567I, G539E mutations in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID171120 | Concentration of compound in rat brain after intravenous injection of 20 mg/kg benzyl-penicillin after 3 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID495663 | Activity at Pseudomonas aeruginosa 51170 beta-lactamase BEL-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID571177 | Antibacterial activity against Neisseria gonorrhoeae assessed as intermediate-resistant isolates by disk agar diffusion method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID558630 | Antimicrobial activity against Streptococcus pneumoniae isolate 4747 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID557479 | Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID258715 | Antibacterial activity against gram negative Chromobacterium violaceum(MTCC 2656) | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1 | Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents. |
| AID74713 | Inhibition of gram negative (resistant) growth. | 1989 | Journal of medicinal chemistry, Jun, Volume: 32, Issue:6 | Synthesis and antimicrobial properties of substituted beta-aminoxypropionyl penicillins and cephalosporins. |
| AID295116 | Antibacterial activity against Listeria monocytogenes ATCC 15313 at 10 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID1168782 | Antibacterial against Staphylococcus aureus ATCC 25923 after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21 | Synthesis, molecular docking and biological evaluation of coumarin derivatives containing piperazine skeleton as potential antibacterial agents. |
| AID524639 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA mutant gene assessed as incidence of susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID524879 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA, ponA and mtrR mutant gene assessed as incidence of resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID1054743 | Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as growth inhibition after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Schiff's base derivatives bearing nitroimidazole moiety: new class of antibacterial, anticancer agents and potential EGFR tyrosine kinase inhibitors. |
| AID324846 | Antimicrobial activity against Neisseria gonorrhoeae 35 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID495705 | Kcat/Km ratio of Klebsiella pneumoniae Beta-lactamase TEM-26 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID554863 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F ST 236 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID533933 | Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus NRS271 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID278529 | Antimicrobial activity against Bifidobacterium longum R0175 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID374674 | Antimicrobial activity against Escherichia coli isolate AMG1 24 hrs biofilms at 350 ug/ml after 1 hr by microtiter plate count method | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID351194 | Volume of distribution in iv dosed neonates with gestational age of 27 to 40 weeks | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks. |
| AID511439 | Antimicrobial activity against Streptococcus uberis ATCC 19436 harboring PAP1A A227T, PBP2B N366I/T402I and PBP2X E381K/Q554E mutation after 15 passages assessed as inhibition of visible growth by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID263111 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USF656 by agar disk diffusion method | 2006 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8 | N-thiolated 2-oxazolidinones: a new family of antibacterial agents for methicillin-resistant Staphylococcus aureus and Bacillus anthracis. |
| AID680337 | TP_TRANSPORTER: uptake in Xenopus laevis oocytes | 1999 | The Journal of pharmacology and experimental therapeutics, Aug, Volume: 290, Issue:2 | The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. |
| AID569262 | Antimicrobial activity against Escherichia coli DH5alpha | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. |
| AID562584 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus agalactiae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1601846 | Antibacterial activity against Bacillus subtilis CMCC 63501 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID1437658 | Antibacterial activity against Escherichia coli ATCC 25922 after 20 to 24 hrs by two-fold microdilution method | |||
| AID534083 | Antibacterial activity against cefotaxime-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID522868 | Antibacterial activity against uropathogenic Escherichia coli UTI89 infected in human 5637 cells assessed as decrease in intracellular bacterial level at 600 to 1000 ug/ml after 12 hrs by serial dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. |
| AID562338 | Ratio of Kcat to Km for Chryseobacterium indologenes 597 metallo-beta-lactamase IND-6 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID269449 | Antibacterial activity against TEM1 beta-lactamase Escherichia coli IV-3-2 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID773424 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CA ATCC BAA-1680 by microdilution technique | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20 | The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds. |
| AID524041 | Antibacterial activity against methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID511292 | Ratio of Kcat/Km for Pseudomonas aeruginosa GES-13 beta lactamase assessed as hydrolysis by spectrometry | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID603190 | Antibacterial activity against Staphylococcus aureus MTCC 96 by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 21, Issue:13 | Efficient synthesis, structural characterization and anti-microbial activity of chiral aryl boronate esters of 1,2-O-isopropylidene-α-D-xylofuranose. |
| AID557505 | Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID341530 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 7 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID508299 | Inhibition of PBP5 in penicillin-resistant Enterococcus faecium D63r membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID1870132 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4515/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID1638904 | Antimicrobial activity against multidrug-resistant Acinetobacter baumannii ATCC 19606 measured after 18 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action. |
| AID368492 | Activity of Escherichia coli CTX-M-15 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID561110 | Antibacterial activity against Pasteurella multocida BB1044 harboring plasmid pB1000 bearing blaROB-1 gene, plasmid 1006 bearing tetO gene and plasmid pB1005 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID374682 | Antimicrobial activity against wild type Escherichia coli K-12 24 hrs biolflim at 350 ug/ml after 1 hr by microtiter plate count method | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID529580 | Ratio of Kcat to Km for Caulobacter crescentus beta-Lactamase CAU-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID418558 | Antibacterial activity against Streptococcus pneumoniae ATCC 6301 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents. |
| AID606030 | Antimicrobial activity against Escherichia coli at 100 ug/mL by agar plate diffusion assay | 2011 | Journal of natural products, May-27, Volume: 74, Issue:5 | Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships. |
| AID557485 | Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID436378 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT method | 2009 | European journal of medicinal chemistry, Oct, Volume: 44, Issue:10 | Synthesis, structure and structure-activity relationship analysis of 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives as potential antibacterial agents. |
| AID341537 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 18 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID522641 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis Ames by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID495745 | Kcat/Km ratio of Acinetobacter baumannii OXA-23 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID529582 | Ratio of Kcat to Km for Bradyrhizobium japonicum beta-Lactamase BJP-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID495737 | Kcat/Km ratio of Pseudomonas aeruginosa AmpC relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID558608 | Antimicrobial activity against Streptococcus pneumoniae isolate 1394 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID543269 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID535766 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 08-043 expressing beta-lactamase TEM-1, MLST type ST-7823 and MAST type ST-1288 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID495798 | Ratio of Kcat to Km of Pseudomonas fluorescens PF-1 beta-lactamase BIC-1 expressed in Escherichia coli DH10B using nitrocefin hydrolysis | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID543283 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp1a, pbp2b and Streptococcus pneumoniae 3191 murM genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID511446 | Antimicrobial activity against Streptococcus uberis ATCC 9529 harboring PAP1A R273P, PBP2B N366I/T402I and PBP2X E381K/Q554E mutation after 11 passages assessed as inhibition of visible growth by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID562379 | Antimicrobial activity against Streptococcus agalactiae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID532990 | Antibacterial activity against Klebsiella pneumoniae NCIM 2883 assessed as growth inhibition in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID571187 | Antibacterial activity against Neisseria gonorrhoeae harboring wild-type GA and Asp-345a insertion in penA genes by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID522655 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis BA1007 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID545511 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC BAA-39 by microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | The synthesis of phenylalanine-derived C5-substituted rhodanines and their activity against selected methicillin-resistant Staphylococcus aureus (MRSA) strains. |
| AID577460 | Inhibition of Bocillin FL binding to PBP2b in laboratory-derived Streptococcus pneumoniae isolate R6 | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID368496 | Activity of Klebsiella oxytoca beta-lactamase K1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID495719 | Activity of Klebsiella oxytoca Beta-lactamase K1 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID587974 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 C69A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID278856 | Antiproliferative effect against primary human osteoblasts assessed as BrdU incorporation into DNA after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID219757 | Minimum protective concentration against beta-lactamase of Xanthomonas maltophilia GN 12873 (CXase-I) | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Design, synthesis, and SAR of novel carbapenem antibiotics with high stability to Xanthomonas maltophilia oxyiminocephalosporinase type II. |
| AID429081 | Antibacterial activity against penicillin-intermediate resistant Neisseria meningitidis after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Combined real-time PCR and pyrosequencing strategy for objective, sensitive, specific, and high-throughput identification of reduced susceptibility to penicillins in Neisseria meningitidis. |
| AID1250521 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hr by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Synthesis and evaluation of new tyrosyl-tRNA synthetase inhibitors as antibacterial agents based on a N2-(arylacetyl)glycinanilide scaffold. |
| AID1601851 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID573573 | Antibacterial activity against beta-lactamase producing Bacteroides uniformis assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID374684 | Antimicrobial activity against kanamycin-resistant Escherichia coli U6 deltayhcQ mutant 24 hrs biofilms at 350 ug/ml after 1 hr by microtiter plate count method | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID524051 | Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID546430 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-1 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID573558 | Antibacterial activity against beta-lactamase producing Bacteroides thetaiotaomicron assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID356761 | Antimicrobial activity against Escherichia coli ATCC 25922 after 18 hrs by microbroth dilution method | 2001 | Journal of natural products, Jul, Volume: 64, Issue:7 | Biological and mechanistic activities of xanthorrizol and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol isolated from Iostephane heterophylla. |
| AID577462 | Inhibition of Bocillin FL binding to PBP2b Thr446Ala/Ala-619-Gly mutant in laboratory-derived Streptococcus pneumoniae isolate R6 | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID508385 | Antibacterial activity against Streptococcus pyogenes harboring mutation in L4 ribosomal protein after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID535761 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 04-025 expressing beta-lactamase TEM-135, MLST type ST-1597 and MAST type ST-1549 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID562608 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID171260 | Concentration of compound in rat liver after intravenous injection of 20 mg/kg benzyl-penicillin after 3 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID209468 | In vitro antibacterial activity against the gram-positive bacteria, erythromycin resistant Streptococcus pyogenes; Not determined | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7 | New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID1852754 | Antibacterial activity against wild type Escherichia coli ATCC 25922 assessed as bacterial growth inhibition by broth microdilution assay | 2022 | RSC medicinal chemistry, Sep-21, Volume: 13, Issue:9 | Design and evaluation of poly-nitrogenous adjuvants capable of potentiating antibiotics in Gram-negative bacteria. |
| AID495713 | Kcat/Km ratio of Pseudomonas aeruginosa IMP-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID374678 | Antimicrobial activity against Escherichia coli isolate AMG1 nylon membrane cultivated 24 hrs biofilms at 350 ug/ml after 1 hr | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID575102 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1765577 | Antibacterial activity against Escherichia coli ATCC 25922 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID448317 | Antibacterial activity against Pseudomonas aeruginosa MTCC 741 by broth dilution method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, photochemical E (trans)-->Z (cis) isomerization and antimicrobial activity of 2-chloro-5-methylpyridine-3-olefin derivatives. |
| AID425863 | Antimicrobial activity against Carnobacterium divergens CIP101029 at 0.5 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID528702 | Antibacterial activity against Streptococcus constellatus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID571184 | Antibacterial activity against Neisseria gonorrhoeae harboring GS gene by disk agar diffusion method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID559515 | Antibacterial activity against Streptococcus pyogenes assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID368499 | Ratio of Kcat to Km of Klebsiella oxytoca beta-lactamase K1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1191521 | Cytostatic activity against human HepG2 cells after 72 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates. |
| AID524882 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing beta-lactamase TEM-1 mutant gene assessed as incidence of resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID356763 | Antimicrobial activity against Pseudomonas aeruginosa 339 after 18 hrs by microbroth dilution method | 2001 | Journal of natural products, Jul, Volume: 64, Issue:7 | Biological and mechanistic activities of xanthorrizol and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol isolated from Iostephane heterophylla. |
| AID1347485 | Antibacterial activity against Klebsiella pneumoniae assessed as zone of inhibition after 24 to 48 hrs by well diffusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations. |
| AID524872 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA mutant gene assessed as incidence of resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID467611 | Dissociation constant, pKa of the compound | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. |
| AID494348 | Antibacterial activity against Escherichia coli by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis, characterization and antimicrobial studies of 2-(4-methoxy-phenyl)-5-methyl-4-(2-arylsulfanyl-ethyl)-2,4-dihydro-[1,2,4] triazolo-3-ones and their corresponding sulfones. |
| AID535759 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 00-002 expressing beta-lactamase TEM-1, MLST type ST-1590 and MAST type ST-270 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID524049 | Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID171118 | Concentration of compound in rat brain after intravenous injection of 20 mg/kg benzyl-penicillin after 20 min; Below detection limit. | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID617971 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino) phenyl-N'-phenyl-thiourea. |
| AID620348 | Antibacterial activity against Pseudomonas aeruginosa RCMB 000102 at 30 ug/ml after 24 hrs by diffusion agar technique | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Synthesis and anti-microbial activity of some 1- substituted amino-4,6-dimethyl-2-oxo-pyridine-3-carbonitrile derivatives. |
| AID556155 | Antimicrobial activity against Streptococcus pneumoniae assessed as resistant isolates broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activity of Iclaprim against respiratory and bacteremic isolates of Streptococcus pneumoniae. |
| AID1168786 | Toxicity in human erythrocyte assessed as hemolysis by measuring hemoglobin release after 3 hrs | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21 | Synthesis, molecular docking and biological evaluation of coumarin derivatives containing piperazine skeleton as potential antibacterial agents. |
| AID1755785 | Antibacterial activity against Bacillus subtilis ATCC 6633 by MH media dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID278540 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium longum ATCC 15707 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID341520 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 25 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID776438 | Antibacterial activity against Escherichia coli ATCC 11775 after 24 hrs by microdilution technique | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives. |
| AID356759 | Antimicrobial activity against Escherichia coli 389 after 18 hrs by microbroth dilution method | 2001 | Journal of natural products, Jul, Volume: 64, Issue:7 | Biological and mechanistic activities of xanthorrizol and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol isolated from Iostephane heterophylla. |
| AID431307 | Antibacterial activity against multidrug resistant Staphylococcus aureus BAA-39 | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis and structure-activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents. |
| AID521355 | Antimicrobial activity against Streptococcus pneumoniae isolate 657 obtained from sputum of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID524644 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA, penB and mtrR mutant gene assessed as incidence of susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID301806 | Antibacterial activity against Escherichia coli ATCC 25922 | 2007 | Bioorganic & medicinal chemistry, Dec-01, Volume: 15, Issue:23 | Direct diazo-transfer reaction on beta-lactam: synthesis and preliminary biological activities of 6-triazolylpenicillanic acids. |
| AID557507 | Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID431306 | Antibacterial activity against Staphylococcus aureus ATCC 29213 | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis and structure-activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents. |
| AID425864 | Antimicrobial activity against Carnobacterium divergens CIP101029 at 3 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID689075 | Antifungal activity against Septoria tritici assessed as zone of inhibition at 0.05 mg by agar diffusion method | 2012 | Journal of natural products, Sep-28, Volume: 75, Issue:9 | Sinularosides A and B, bioactive 9,11-secosteroidal glycosides from the South China Sea soft coral Sinularia humilis Ofwegen. |
| AID269444 | Antibacterial activity against wild type Staphylococcus aureus SG 511 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID206461 | In vitro antibacterial activity against the gram-positive bacteria, penicillin sensitive Staphylococcus aureus (663E) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7 | New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID619678 | Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 by broth microdilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives. |
| AID1437665 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 20 to 24 hrs by two-fold microdilution method | |||
| AID171256 | Concentration of compound in rat kidney after intravenous injection of 20 mg/kg benzyl-penicillin after 10 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID1546172 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as zone of inhibition at 100 ug/ml after 24 hrs by disc diffusion method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID528529 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B12 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID1279010 | Antibacterial activity against methicillin-resistant Staphylococcus aureus H 5996/08 after 48 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID269456 | Antifungal activity against Candida albicans BMSY 212 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID447058 | Antibacterial activity against Proteus vulgaris ATCC 8427 at 10 IU after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID541176 | Antimicrobial activity against multidrug resistant Streptococcus pneumoniae serotype 19F S43 carring erm(B),mef(E) and tet(M) gene | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | New composite genetic element of the Tn916 family with dual macrolide resistance genes in a Streptococcus pneumoniae isolate belonging to clonal complex 271. |
| AID1348086 | Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID285443 | Ratio of kcat to Km of Citrobacter gillenii CIP 106783 Beta-lactamase GIL1 expressed in Escherichia coli DH10B relative to benzyl-penicillin | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID341339 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 57 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID1638900 | Antimicrobial activity against drug-susceptible Enterococcus faecium ATCC 49624 measured after 18 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action. |
| AID495696 | Activity of Serratia marcescens SME-3 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID340910 | Increase in pbp2B gene expression in penicillin-resistant Streptococcus gordonii with penicillin binding protein PR1_2 evolved mutation assessed as relative luciferase units relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID1076538 | Antibacterial activity against Pseudomonas aeruginosa ATCC 13525 after 24 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity. |
| AID466787 | Antibacterial activity against Bacillus subtilis ATCC 6633 | 2010 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6 | Design and synthesis of novel deoxybenzoin derivatives as FabH inhibitors and anti-inflammatory agents. |
| AID528530 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B40 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID543482 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 murM, pbp2x, pbp2b and Streptococcus pneumoniae 3191 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID263110 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USF655 by agar disk diffusion method | 2006 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8 | N-thiolated 2-oxazolidinones: a new family of antibacterial agents for methicillin-resistant Staphylococcus aureus and Bacillus anthracis. |
| AID561104 | Antibacterial activity against Pasteurella multocida BB1038 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB1005 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID325449 | Antibacterial activity against Staphylococcus aureus ATCC 3556 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID285157 | Antimicrobial susceptibility of tetracycline-resistant Streptococcus pneumoniae from respiratory tract disease patient assessed as percent susceptible isolates | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. |
| AID340850 | Increase in pbp2A gene expression in penicillin-resistant Streptococcus gordonii with penicillin binding protein PR1_2 evolved mutation at 1/2 times MIC assessed as relative luciferase units relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID524068 | Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID557490 | Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID529664 | Ratio of Kcat to Km for Pseudomonas aeruginosa 166301 beta-lactamase VIM-16 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID1063967 | Antibacterial activity against Staphylococcus aureus CCM 4516/08 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2 | Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. |
| AID1778125 | Antimicrobial activity against Bacillus anthracis assessed as microbial growth inhibition by CLSI-protocol based broth microdilution assay | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4 | Opportunities and Limitations for Assigning Relative Configurations of Antibacterial Bislactones using GIAO NMR Shift Calculations. |
| AID557472 | Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID559516 | Antibacterial activity against Streptococcus anginosus assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID1437664 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 after 20 to 24 hrs by two-fold microdilution method | |||
| AID528527 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B8 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID1348083 | Antimicrobial activity against Candida parapsilosis ATCC 90018 assessed as zone of inhibition at 50 ug per disc after 48 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID554859 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 3247 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID545145 | Ratio of Kcat to Km of CMY-2 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID442480 | Antibacterial activity against Escherichia coli MTCC 443 by broth dilution method | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1 | Click chemistry: studies on the synthesis of novel fluorous tagged triazol-4-yl substituted quinazoline derivatives and their biological evaluation--theoretical and experimental validation. |
| AID531605 | Activity of Escherichia coli beta-lactamase SHV-11 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID699539 | Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake at 20 uM by scintillation counting | 2012 | Journal of medicinal chemistry, May-24, Volume: 55, Issue:10 | Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. |
| AID431310 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis ATCC 51625 | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis and structure-activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents. |
| AID574170 | Antibacterial activity against Escherichia coli MG1655 grown as biofilms harboring plasmid pBR322 carrying blaTEM-1 and tetA(C) genes after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Induction of multidrug resistance mechanism in Escherichia coli biofilms by interplay between tetracycline and ampicillin resistance genes. |
| AID562406 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID562340 | Ratio of Kcat to Km for Chryseobacterium indologenes 597 metallo-beta-lactamase IND-2 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID587975 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 F160T mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID557513 | Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID209246 | Minimum inhibitory concentration against aerobic organisms Streptococcus faecalis strain 2864 | 1982 | Journal of medicinal chemistry, Apr, Volume: 25, Issue:4 | Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain. |
| AID511438 | Antimicrobial activity against Streptococcus uberis ATCC 19436 assessed as inhibition of visible growth after 24 hrs by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID524037 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae 1076 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID1128828 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by broth microdilution method | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Spiromastixones A-O, antibacterial chlorodepsidones from a deep-sea-derived Spiromastix sp. fungus. |
| AID341346 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 16 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID503230 | Ratio of MIC for penicillin-resistant Streptococcus pneumoniae 38030509 to MIC for penicillin-sensitive Streptococcus pneumoniae R6 | 2007 | Nature chemical biology, Sep, Volume: 3, Issue:9 | Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. |
| AID1755799 | Antibacterial activity against Escherichia coli ATCC 35218 by MH media dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID324850 | Antimicrobial activity against Neisseria gonorrhoeae 128 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID521346 | Antimicrobial activity against Streptococcus pneumoniae isolate 2904 obtained from blood of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID569339 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID1243284 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus clinical isolates by standard broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Synthesis and biological evaluation of levofloxacin core-based derivatives with potent antibacterial activity against resistant Gram-positive pathogens. |
| AID171262 | Concentration of compound in rat liver after intravenous injection of 20 mg/kg benzyl-penicillin after 5 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID368544 | Activity of Pseudomonas aeruginosa 18SH AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1601842 | Antibacterial activity against Staphylococcus aureus CMCC 25923 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID535767 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 08-044 expressing beta-lactamase TEM-1, MLST type ST-7823 and MAST type ST-1288 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | |||
| AID528536 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B514 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID1112104 | Antifungal activity against Microbotryum violaceum by agar diffusion test | 2012 | Fitoterapia, Apr, Volume: 83, Issue:3 | Pyrenocines J-M: four new pyrenocines from the endophytic fungus, Phomopsis sp. |
| AID529904 | Antimicrobial activity against Leptospira interrogans serovar Canicola isolate 11 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID428136 | Antimicrobial activity against penicillin-resistant Streptococcus gordonii PR1_2evolved mutant co-cultured with wild type Streptococcus gordoni assessed as loss of viability at stationary phase of growth at 0.5 ug/mL after 15 hrs | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory. |
| AID561103 | Antibacterial activity against Pasteurella multocida BB1037 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB1005 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID1254303 | Antibacterial activity against Staphylococcus epidermidis H 6966/08 after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID428130 | Antimicrobial activity against penicillin-resistant Streptococcus gordonii PR1_2evolved mutant assessed as generation time at mid-logarithmic phase of growth | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory. |
| AID545509 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC 700787 by microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | The synthesis of phenylalanine-derived C5-substituted rhodanines and their activity against selected methicillin-resistant Staphylococcus aureus (MRSA) strains. |
| AID567282 | Ratio of Kcat to Km for Acinetobacter baumannii ADC-11 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID1870136 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 77/CF assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID1882850 | Binding affinity to Staphylococcus aureus ATCC 43300 50S ribosomal subunit assessed as dissociation constant by surface plasmon resonance analysis | |||
| AID263107 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USF652 by agar disk diffusion method | 2006 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8 | N-thiolated 2-oxazolidinones: a new family of antibacterial agents for methicillin-resistant Staphylococcus aureus and Bacillus anthracis. |
| AID524036 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 2527 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID1765574 | Antibacterial activity against Bacillus subtilis ATCC 23857 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID599146 | Antibacterial activity against Bacillus subtilis after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Mar, Volume: 43, Issue:3 | Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. |
| AID1546165 | Antimicrobial activity against Bacillus subtilis assessed as zone of inhibition at 5 mg/ml after 24 to 48 hrs by well diffusion method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID582266 | Antimicrobial activity against Bacillus cereus ATCC 4342 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Efficacy of oritavancin in a murine model of Bacillus anthracis spore inhalation anthrax. |
| AID619769 | Antibacterial activity against Staphylococcus aureus RCMB 000106 at 30 mg/ml after 24 hrs by agar well diffusion method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Design and synthesis of some new thiophene, thienopyrimidine and thienothiadiazine derivatives of antipyrine as potential antimicrobial agents. |
| AID332338 | Antimicrobial activity against Bacillus subtilis 327 after 18 hrs by microbroth dilution method | 2003 | Journal of natural products, Feb, Volume: 66, Issue:2 | Antibacterial diterpenes from Calceolaria pinifolia. |
| AID559521 | Antibacterial activity against Streptococcus oralis assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID335498 | Antimicrobial activity against Escherichia coli imp 389 after 18 to 20 hrs by standard broth microdilution method | 2002 | Journal of natural products, Jun, Volume: 65, Issue:6 | New antimicrobial cycloartane triterpenes from Acalypha communis. |
| AID1546645 | Antibacterial activity against Klebsiella pneumoniae MTCC 618 assessed as diameter of zone of inhibition at 200 ug/ml after 24 hrs by agar well diffusion method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1 | Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents. |
| AID1870117 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4463/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID368537 | Ratio of Kcat to Km of Providencia stuartii AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID625288 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID285269 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM28 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID588116 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring PBP1 L421P mutant gene, PBP2 XXXVII pattern, deletion of nucleotide A from mtrA promoter, MtrR G45D mutant MAST 299 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID324839 | Antimicrobial activity against Neisseria gonorrhoeae 273 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID425612 | Cytotoxicity against mouse J774A1 cells assessed as release of adenylate kinase at 100 ug/ml after 3 hrs by total cell protein assay relative to control | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics. |
| AID495734 | Kcat/Km ratio of Klebsiella oxytoca Beta-lactamase K1 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID539694 | Antifungal activity against Pseudomonas aeruginosa MTCC 741 by broth dilution method | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | Indium(III) chloride catalyzed three-component coupling reaction: a novel synthesis of 2-substituted aryl(indolyl)kojic acid derivatives as potent antifungal and antibacterial agents. |
| AID417435 | Antibacterial activity against Pseudomonas fluorescens after 24 hrs by MTT method | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis and biological evaluation of novel luteolin derivatives as antibacterial agents. |
| AID539692 | Antifungal activity against Staphylococcus epidermidis MTCC 2639 by broth dilution method | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | Indium(III) chloride catalyzed three-component coupling reaction: a novel synthesis of 2-substituted aryl(indolyl)kojic acid derivatives as potent antifungal and antibacterial agents. |
| AID483194 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 by microbroth dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID554857 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 2918 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID524245 | Antimicrobial activity against Escherichia coli DH5alpha expressing SHV-1 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID577455 | Inhibition of Bocillin FL binding to PBP2b PBP2b 443SSNA mutant in Streptococcus pneumoniae isolate 8009 harboring E333G, N470K, E476G, T489S, E506D, and N538D mutant genes | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID559705 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus P1386 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID21924 | Relative Vmax was reported | 1984 | Journal of medicinal chemistry, Mar, Volume: 27, Issue:3 | Dependence of beta-lactamase stability on substructures within beta-lactam antibiotics. |
| AID278547 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium bifidum ATCC 15696 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID557517 | Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID269446 | Antibacterial activity against VRE Enterococcus faecalis 1528 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID543272 | Antimicrobial activity against Streptococcus pneumoniae 72521 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID171251 | Concentration of compound in rat kidney after intravenous injection of 20 mg/kg benzyl-penicillin after 20 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID295104 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 10 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID210368 | In vitro antibacterial activity against the gram-positive bacteria, penicillin sensitive Streptococcus pneumoniae (3512) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7 | New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID341525 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 30 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID375919 | Antibacterial activity against Bacillus subtilis ATCC 23857 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents. |
| AID524050 | Binding affinity to methicillin-, vancomycin-susceptible Staphylococcus aureus ATCC 29213 PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID171265 | Concentration of compound in rat lung after intravenous injection of 20 mg/kg benzyl-penicillin after 10 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID625285 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID287378 | Antibacterial activity against Listeria monocytogenes after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID573140 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus agalactiae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1091744 | Antibacterial activity against Chromobacterium violaceum MTCC 2656 assessed as inhibition zones at 100 ug/disk at 37 degC for 24 hr | 2009 | Chemical & pharmaceutical bulletin, Jul, Volume: 57, Issue:7 | Synthesis, nematicidal and antimicrobial properties of Bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2H-pyrazolo[3,4-d]thiazol-5-yl]phenyl]methanes. |
| AID530341 | Ratio of Kcat to Km for Pseudomonas aeruginosa VIM-1 beta-lactamase | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID521345 | Antimicrobial activity against Streptococcus pneumoniae isolate k-637 obtained from CSF of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID680174 | TP_TRANSPORTER: inhibition of MTX uptake (MTX: 1 uM, PCG: 1000 uM) in OAT4-expressing S2 cells | 2002 | The Journal of pharmacology and experimental therapeutics, Aug, Volume: 302, Issue:2 | Characterization of methotrexate transport and its drug interactions with human organic anion transporters. |
| AID565817 | Antimicrobial activity against Neisseria gonorrhoeae isolates by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Update on fusidic acid (CEM-102) tested against Neisseria gonorrhoeae and Chlamydia trachomatis. |
| AID495722 | Activity of Pseudomonas aeruginosa AmpC relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID559709 | Antimicrobial activity against penicillin-sensitive Staphylococcus epidermidis P1111 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID587973 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 D240A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID341536 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 13 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID535639 | Antimicrobial activity against Group B streptococcus serotype VI R1 harboring F395L, V405A, R433H, H438Y, and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID495702 | Kcat/Km ratio of Klebsiella pneumoniae SHV-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID557484 | Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID584847 | Ratio of Kcat to Km for Aeromonas allosaccharophila AL-1 beta-lactamase PER6 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID543483 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x, pbp2b, pbp1a and Streptococcus pneumoniae 72521 murM genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID70618 | In vitro antimicrobial activity against Escherichia coli ATCC 39188 was determined | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Design, synthesis, and SAR of novel carbapenem antibiotics with high stability to Xanthomonas maltophilia oxyiminocephalosporinase type II. |
| AID494346 | Antibacterial activity against Staphylococcus aureus by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis, characterization and antimicrobial studies of 2-(4-methoxy-phenyl)-5-methyl-4-(2-arylsulfanyl-ethyl)-2,4-dihydro-[1,2,4] triazolo-3-ones and their corresponding sulfones. |
| AID171249 | Concentration of compound in rat kidney after intravenous injection of 20 mg/kg benzyl-penicillin after 1 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID617968 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino) phenyl-N'-phenyl-thiourea. |
| AID278541 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium longum R0175 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID524064 | Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID524873 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing mtrR mutant gene assessed as incidence of resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID558605 | Antimicrobial activity against Streptococcus pneumoniae isolate 1146 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID324843 | Antimicrobial activity against Neisseria gonorrhoeae 65 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID558322 | Antibacterial activity against bla gene-positive and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni NCTC 11168 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID535641 | Antimicrobial activity against Group B streptococcus serotype V C1 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID340738 | Ratio of Kcat to Km of Chryseobacterium indologenes metallo-beta-lactamase IND-5 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID1237607 | Antibacterial activity against Proteus vulgaris ATCC49101 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID1254299 | Antibacterial activity against Staphylococcus aureus CCM 4516/08 after 48 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID535350 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as resistant isolates by by based on po dosed broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID557491 | Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1755809 | Antibacterial activity against Staphylococcus aureus ATCC 6538 by MH media dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID451356 | Antimicrobial activity against Cryptococcus albidus NBRC0378 after 24 hrs by broth dilution method | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. |
| AID1653058 | Antibacterial activity against Escherichia coli | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Isatin derivatives and their anti-bacterial activities. |
| AID558625 | Antimicrobial activity against Streptococcus pneumoniae isolate 3458 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID582267 | Antimicrobial activity against Bacillus cereus ATCC 4342 selected after 20 daily cycles of drug selection followed by 5 days of nonselective growth by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Efficacy of oritavancin in a murine model of Bacillus anthracis spore inhalation anthrax. |
| AID1565595 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 936 after 18 hrs by CLSI based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity. |
| AID585181 | Ratio of Kcat to Km for Beta-lactamase GES-1 E104, G170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID1437928 | Antibacterial activity against Porphyromonas gingivalis ATCC 33277 after 24 hrs | 2017 | Journal of natural products, 01-27, Volume: 80, Issue:1 | Dibenzofurans and Pseudodepsidones from the Lichen Stereocaulon paschale Collected in Northern Quebec. |
| AID476929 | Human intestinal absorption in po dosed human | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | Neural computational prediction of oral drug absorption based on CODES 2D descriptors. |
| AID508309 | Inhibition of Enterococcus faecium low-affinity PBP5fm assessed as rate constant for enzyme acylation by spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID524666 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA and mtrR mutant gene assessed as percentage intermediate isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID666780 | Antifungal activity against Microbotryum violaceum at 0.05 mg by agar diffusion test | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13 | Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. |
| AID1091745 | Antibacterial activity against Enterobacter aerogenes MTCC 39 assessed as inhibition zones at 100 ug/disk at 37 degC for 24 hr | 2009 | Chemical & pharmaceutical bulletin, Jul, Volume: 57, Issue:7 | Synthesis, nematicidal and antimicrobial properties of Bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2H-pyrazolo[3,4-d]thiazol-5-yl]phenyl]methanes. |
| AID519749 | Ratio of Kcat to Km for Klebsiella pneumoniae Beta-Lactamase SHV-72 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID542616 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x2349 mutant gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID368521 | Ratio of Kcat to Km of Enterobacter cloacae 4092 AmpC (E2) assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID524067 | Binding affinity to methicillin-, vancomycin-susceptible Staphylococcus aureus ATCC 29213 PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID529578 | Ratio of Kcat to Km for Chryseobacterium meningosepticum beta-Lactamase GOB-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID575077 | Antimicrobial activity against Streptococcus pneumoniae serotype 3 assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID529577 | Ratio of Kcat to Km for Pseudomonas maltophilia ULA-511 beta-Lactamase L-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID525549 | Antimicrobial activity against ampicillin resistant nontypeable Haemophilus influenzae isolate BB1052 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID1072981 | Antimicrobial activity against Candida albicans MY 1055 after 20 hrs by 2-fold serial broth dilution method | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Isolation, structure elucidation, and biological activity of altersolanol P using Staphylococcus aureus fitness test based genome-wide screening. |
| AID1243283 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 by standard broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Synthesis and biological evaluation of levofloxacin core-based derivatives with potent antibacterial activity against resistant Gram-positive pathogens. |
| AID1243289 | Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 by standard broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Synthesis and biological evaluation of levofloxacin core-based derivatives with potent antibacterial activity against resistant Gram-positive pathogens. |
| AID561112 | Antibacterial activity against Pasteurella multocida BB1046 harboring plasmid pB1003 bearing blaROB-1 gene and plasmid pB1002 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID530515 | Antimicrobial activity against group B Streptococcus sp. 'group B' isolate 6149-03 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID680167 | TP_TRANSPORTER: inhibition of Ochratoxin A uptake (OTA: 1 uM, PCG: 200 uM) in OAT4-expressing S2 cells | 2002 | Biochimica et biophysica acta, Jun-12, Volume: 1590, Issue:1-3 | Role of human organic anion transporter 4 in the transport of ochratoxin A. |
| AID1765575 | Antibacterial activity against Enterococcus faecalis ATCC 29212 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID374672 | Antimicrobial activity against tetracycline-resistant Escherichia coli U1 rapA mutant grown as biofilms after 24 hrs by spectrophotometric method | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID625279 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID549015 | Antimicrobial activity against viridans group Streptococcus assessed as percent resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID340770 | Increase in pbp2A gene expression in penicillin-resistant Streptococcus gordonii with penicillin binding protein PR1_2 evolved mutation assessed as relative luciferase units relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID245356 | Minimum inhibitory concentration against Pseudomonas aeruginosa (Gram-negative) by broth dilution method | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of 2,4,6-tri substituted s-triazines. |
| AID1601854 | Antibacterial activity against multidrug-resistant Pseudomonas aeruginosa ATCC BAA-2111 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID1054725 | Antibacterial activity against Escherichia coli (Migula) Castellani and Chalmers ATCC 25922 after overnight incubation by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Pahangensin A and B, two new antibacterial diterpenes from the rhizomes of Alpinia pahangensis Ridley. |
| AID586083 | Antimicrobial activity against Neisseria gonorrhoeae isolates harboring non-mosaic penicillin-binding protein 2 penA assessed as resistant isolates by disk susceptibility test | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characteristics and dissemination of mosaic penicillin-binding protein 2-harboring multidrug-resistant Neisseria gonorrhoeae isolates with reduced cephalosporin susceptibility in northern Taiwan. |
| AID531425 | Antibacterial activity against Streptococcus pneumoniae serotype 22 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID569347 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID311524 | Oral bioavailability in human | 2007 | Bioorganic & medicinal chemistry, Dec-15, Volume: 15, Issue:24 | Hologram QSAR model for the prediction of human oral bioavailability. |
| AID557497 | Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID498376 | Antimicrobial activity against wild type streptomycin-susceptible Streptococcus gordonii harboring P438R mutation in ptsI infected in Wistar rat assessed as decrease in bacterial infection at 300000 U/kg, sc administered 16 hrs after infection every 12 hr | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | A single mutation in enzyme I of the sugar phosphotransferase system confers penicillin tolerance to Streptococcus gordonii. |
| AID557520 | Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID524070 | Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID540179 | Antibacterial activity against Klebsiella pneumoniae after 24 hrs by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and anti-tubercular and antimicrobial activities of some 2r,4c-diaryl-3-azabicyclo[3.3.1]nonan-9-one N-isonicotinoylhydrazone derivatives. |
| AID522664 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis BA1024 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID1870118 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4904/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID372640 | Ratio of Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-35 to Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-158 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID528739 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B516 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID535634 | Antimicrobial activity against Group B streptococcus serotype VI R6 harboring F395L, V405A, R433H, H438Y, A374V and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID521828 | Antimicrobial activity against Streptococcus pneumoniae in meningitis patients by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID542619 | Antimicrobial activity against streptomycin- resistant Streptococcus pneumoniae R6 harboring PBP2x2349 mutant gene and Janus disruption at PBP1a after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID575103 | Antimicrobial activity against Streptococcus pneumoniae serotype 23A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID520724 | Activity of Acinetobacter baumannii phenotype 2 beta-lactamase assessed per mg of protein at 100 uM | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID681115 | TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in Caco-2 cells | 2005 | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jan, Volume: 59, Issue:1 | Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. |
| AID74700 | Inhibition of gram negative bacteria growth. | 1989 | Journal of medicinal chemistry, Jun, Volume: 32, Issue:6 | Synthesis and antimicrobial properties of substituted beta-aminoxypropionyl penicillins and cephalosporins. |
| AID524874 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penB mutant gene assessed as incidence of resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID341532 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 20 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID530501 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype IA isolate 6649-05 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID520727 | Activity of Escherichia coli TOP10 beta-lactamase OXA-97 assessed as specific activity per mg of protein at 100 uM | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. |
| AID405086 | Ratio of Kcat to Km of Citrobacter freundii PER2 beta lactamase relative to cephalothin | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID592501 | Antifungal activity against Microbotryum violaceum assessed as zone of inhibition measured as radius at 50 ug by agar diffusion assay | 2011 | Journal of natural products, Mar-25, Volume: 74, Issue:3 | Diversonol and blennolide derivatives from the endophytic fungus Microdiplodia sp.: absolute configuration of diversonol. |
| AID524071 | Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID1279015 | Antibacterial activity against Escherichia coli CCM 4517 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID1601850 | Antibacterial activity against Pseudomonas aeruginosa CMCC 10104 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID368534 | Ratio of Kcat to Km of Morganella morganii AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID287377 | Antibacterial activity against Mycobacterium smegmatis after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID269451 | Antibacterial activity against PSE1 beta-lactamase Pseudomonas aeruginosa IV-3-13 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID511451 | Antimicrobial activity against Streptococcus uberis isolate 1.11 harboring PAP1A G386R, PBP2B T593I and PBP2X E381K/Q554E mutation assessed as inhibition of visible growth after 24 hrs by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID1168784 | Antibacterial against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21 | Synthesis, molecular docking and biological evaluation of coumarin derivatives containing piperazine skeleton as potential antibacterial agents. |
| AID1254308 | Antibacterial activity against Klebsiella pneumoniae D 11750/08 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID287372 | Antibacterial activity against Staphylococcus aureus after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID587976 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 G232A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID206459 | In vitro antibacterial activity against the gram-positive bacteria, penicillin sensitive Staphylococcus aureus (3072) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7 | New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID519629 | Antimicrobial activity against Escherichia coli JM83 without producing beta-lactamase OXA-63 after 3 days by Etest | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID603194 | Antibacterial activity against Klebsiella pneumoniae MTCC 618 by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 21, Issue:13 | Efficient synthesis, structural characterization and anti-microbial activity of chiral aryl boronate esters of 1,2-O-isopropylidene-α-D-xylofuranose. |
| AID278531 | Antimicrobial activity against Bifidobacterium pseudolongum ATCC 25562 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID263114 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USF659 by agar disk diffusion method | 2006 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8 | N-thiolated 2-oxazolidinones: a new family of antibacterial agents for methicillin-resistant Staphylococcus aureus and Bacillus anthracis. |
| AID558629 | Antimicrobial activity against Streptococcus pneumoniae isolate 3791 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID522657 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis V770 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID557496 | Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID562373 | Antimicrobial activity against Streptococcus Group C clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID562367 | Antimicrobial activity against Streptococcus Group F clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1180458 | Selectivity index, ratio of IC50 for human HepG2 cells to MIC for methicillin-resistant Staphylococcus aureus H 5996/08 | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates. |
| AID577459 | Antimicrobial activity against laboratory-derived Streptococcus pneumoniae isolate R6 harboring Thr446Ala/Ala-619-Gly mutant gene by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID532982 | Antibacterial activity against Escherichia coli W3110 in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID418554 | Antibacterial activity against multidrug-resistant Staphylococcus aureus BAA-39 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents. |
| AID1638901 | Antimicrobial activity against Enterococcus faecalis ATCC 29212 measured after 18 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action. |
| AID562581 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus pyogenes clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID573565 | Antibacterial activity against beta-lactamase producing Bacteroides vulgatus assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID524669 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA, ponA and mtrR mutant gene assessed as percentage intermediate isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID372641 | Ratio of Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-1 to Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-158 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID542624 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338G mutant gene, disruption at PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID561105 | Antibacterial activity against Pasteurella multocida BB1039 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID1565592 | Antibacterial activity against Klebsiella pneumoniae ATCC 700603 after 18 hrs by CLSI based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity. |
| AID521349 | Antimicrobial activity against Streptococcus pneumoniae isolate 909 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID207928 | Compound was evaluated for the antibacterial activity against Staphylococcus aureus with the strains beta-Lactamase-positive (LAC+)/ beta-Lactamase-negative (LAC-); 64/0.03 | 1984 | Journal of medicinal chemistry, Mar, Volume: 27, Issue:3 | Dependence of beta-lactamase stability on substructures within beta-lactam antibiotics. |
| AID1870130 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4679/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID521830 | Antimicrobial activity against Streptococcus pneumoniae isolated from meningitis patient assessed as percent susceptible isolates by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID1454339 | Antibacterial activity Klebsiella pneumoniae MTCC 618 by agar well method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis and biological evaluation of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thioglycosides. |
| AID495728 | Activity of Pseudomonas aeruginosa IMP-1 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID562413 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group C clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1546169 | Antimicrobial activity against Proteus mirabilis | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | |||
| AID584848 | Ratio of Kcat to Km for Aeromonas allosaccharophila AL-1 beta-lactamase PER2 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID588117 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB G120K, A121D mutant gene, PBP1 L421P mutant gene, PBP2 XXXVIII pattern, deletion of nucleotide A from mtrA promoter, MAST 3570 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID521829 | Antimicrobial activity against Streptococcus pneumoniae in non-meningitis patients by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID582966 | Antimicrobial activity against beta-lactamase A-deficient Yersinia enterocolitica GY5717 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID524877 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA, penB and mtrR mutant gene assessed as incidence of resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID368494 | Ratio of Kcat to Km of Escherichia coli CTX-M-15 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1601848 | Antibacterial activity against Escherichia coli CMCC 44568 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID341338 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 11 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID1870133 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 5079/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID522393 | Ratio of Kcat Km for Aeromonas caviae Beta-lactamase CAV1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID524034 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 24 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID381179 | Antibacterial activity against penicillin-resistant Staphylococcus aureus after 24 to 72 hrs by disk diffusion method | 1999 | Journal of natural products, Sep, Volume: 62, Issue:9 | Antimicrobial and antitumor activities of mycosporulone. |
| AID520389 | Ratio of Kcat to Km for Pseudomonas aeruginosa COL-1 metallo-beta lactamase VIM-2 over Kcat to Km for Pseudomonas aeruginosa M5109 metallo-beta-lactamase VIM-11 | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID210366 | In vitro antibacterial activity against the gram-positive bacteria, penicillin sensitive Streptococcus pneumoniae (3272) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7 | New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID558335 | Antibacterial activity against Campylobacter jejuni isolate P1093 harboring blaOXA-61::cat gene by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID530499 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype IA isolate 3047-05 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID451353 | Antimicrobial activity against Pseudomonas aeruginosa NBRC13275 after 24 hrs by broth dilution method | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. |
| AID524035 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 3413 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID495840 | Hydrolytic activity of beta-lactamase VIM-1 in Escherichia coli DH5alpha expressing pBCLL/39H by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID528707 | Antibacterial activity against Streptococcus pyogenes group A clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1706284 | Half life of compound | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | β-lactam antibiotics: An overview from a medicinal chemistry perspective. |
| AID533937 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus ATCC 29213 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID562370 | Antimicrobial activity against Streptococcus Group G clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID619543 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: synthesis, molecular docking and structure-activity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones. |
| AID1072984 | Antimicrobial activity against wild-type Escherichia coli MB 2884 after 20 hrs by 2-fold serial broth dilution method | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Isolation, structure elucidation, and biological activity of altersolanol P using Staphylococcus aureus fitness test based genome-wide screening. |
| AID1243287 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates by standard broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Synthesis and biological evaluation of levofloxacin core-based derivatives with potent antibacterial activity against resistant Gram-positive pathogens. |
| AID447057 | Antibacterial activity against Micrococcus luteus La 2971 at 10 IU after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID523001 | Cytotoxicity against human 5637 cells assessed as mild induction of cell death by trypan blue exclusion assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. |
| AID1437930 | Bactericidal activity against Porphyromonas gingivalis ATCC 33277 after 24 hrs | 2017 | Journal of natural products, 01-27, Volume: 80, Issue:1 | Dibenzofurans and Pseudodepsidones from the Lichen Stereocaulon paschale Collected in Northern Quebec. |
| AID529323 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae serotype 19A URA3635 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID562757 | Ratio of Kcat to Km for Klebsiella pneumoniae AH27 CTX-M-15 beta-lactamase | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID495900 | Activity of Pseudomonas aeruginosa VIM-2 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID322495 | Cmax in human adults at 600 mg/kg, iv administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID557473 | Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | |||
| AID541023 | Ratio of Kcat to Km for Burkholderia cenocepacia 07-34 beta-lactamase PenB1 expressed in Escherichia coli Top10 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID1778127 | Antimicrobial activity against Staphylococcus aureus assessed as microbial growth inhibition by CLSI-protocol based broth microdilution assay | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4 | Opportunities and Limitations for Assigning Relative Configurations of Antibacterial Bislactones using GIAO NMR Shift Calculations. |
| AID535354 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as resistant isolates by by based on parenterally dosed broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID1428252 | Antibacterial activity against Staphylococcus aureus RCMB 000108 assessed as zone of inhibition at 30 ug/ml | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold. |
| AID340852 | Effect on pbp2B gene expression in penicillin-resistant Streptococcus gordonii with penicillin binding protein PR1_2 evolved mutation assessed as relative luciferase units relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID524670 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA, penB and ponA mutant gene assessed as percentage intermediate isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID508306 | Inhibition of PBP5 in wild type Enterococcus faecium D63 membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID573145 | Antibacterial activity against penicillin-susceptible Streptococcus viridans assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1209734 | Inhibition of mouse OAT1 expressed in CHO cells assessed as inhibition of fluorescein uptake at 500 uM over 20 mins relative to untreated-control | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4 | Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. |
| AID368516 | Ratio of Kcat to Km of Pseudomonas aeruginosa IMP1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID558604 | Antimicrobial activity against Streptococcus pneumoniae isolate 1055 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID28560 | Concentration of compound in human brain tissues after intravenous administration of 2 g dose | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. Synthesis and properties of some dihydropyridine and dihydroiosquinoline derivatives of benzylpenicillin. |
| AID532676 | Antimicrobial activity against ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates assessed as susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal. |
| AID368522 | Ratio of Kcat to Km of Enterobacter cloacae 4092 AmpC (E2) assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1149039 | Antibacterial activity against Salmonella schottmuelleri assessed as growth inhibition incubated for 24 hrs using mixed anhydride | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 | Beta-lactam antibiotics with N-oxide side chains. 1. Quinoxaline N-oxides. |
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | |||
| AID495706 | Kcat/Km ratio of Escherichia coli CMY-2 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID70752 | In vitro Minimum inhibitory concentration against Escherichia coli ATCC 25922 | 1981 | Journal of medicinal chemistry, Oct, Volume: 24, Issue:10 | Synthesis and evaluation of ureido- and vinylureidopenicillins as inhibitors of intraruminal lactic acid production. |
| AID417436 | Antibacterial activity against Escherichia coli after 24 hrs by MTT method | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2 | Synthesis and biological evaluation of novel luteolin derivatives as antibacterial agents. |
| AID278558 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium animalis ATCC 27536 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID575083 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID340764 | Antibacterial activity against penicillin-resistant Streptococcus gordonii with penicillin binding protein PR1_2 evolved mutation | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii. |
| AID341344 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 27 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID373216 | Ratio of Kcat for Bacillus cereus beta-lactamase BcI to Kcat for Bacillus clausii NR beta-lactamase BCL1 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID394487 | Activity of Escherichia coli beta-lactamase ACC4 by UV spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID539691 | Antifungal activity against Staphylococcus aureus MTCC 96 by broth dilution method | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | Indium(III) chloride catalyzed three-component coupling reaction: a novel synthesis of 2-substituted aryl(indolyl)kojic acid derivatives as potent antifungal and antibacterial agents. |
| AID495732 | Kcat/Km ratio of Klebsiella pneumoniae SHV-1 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID521356 | Antimicrobial activity against Streptococcus pneumoniae isolate 2907 obtained from sinusitis of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID210367 | In vitro antibacterial activity against the gram-positive bacteria, penicillin sensitive Streptococcus pneumoniae (3273) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7 | New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID540210 | Clearance in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID588115 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring PBP2 XXXVIII pattern, deletion of nucleotide A from mtrA promoter, MAST 3553 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID679175 | TP_TRANSPORTER: inhibition of Pravastatin uptake in Oat3-expressing LLC-PK1 cells | 2002 | The Journal of pharmacology and experimental therapeutics, Mar, Volume: 300, Issue:3 | Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. |
| AID341524 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 12 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID530513 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype IV isolate 3454-03 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID372620 | Ratio of Kcat to Km for Escherichia coli DH5alpha beta-lactamase TEM-1 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID573598 | Antibacterial activity against Fusobacterium varium assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID575099 | Antimicrobial activity against Streptococcus pneumoniae serotype 15A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID409954 | Inhibition of mouse brain MAOA | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21 | Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. |
| AID1546649 | Antibacterial activity against Escherichia coli MTCC 443 assessed as reduction in microbial growth after 24 hrs by CLSI based microdilution method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1 | Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents. |
| AID1755800 | Antibacterial activity against Pseudomonas aeruginosa ATCC 13525 by MH media dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID322510 | AUC (0 to 12) in human term neonates at 15 mg/kg, im administered every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID557493 | Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID530342 | Ratio of Kcat to Km for Pseudomonas aeruginosa VIM-13 beta-lactamase | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID278546 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium bifidum R0071 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1072990 | Bactericidal activity against Streptococcus mutans ATCC 35668 after 3 days | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Pyrano-isoflavans from Glycyrrhiza uralensis with antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis. |
| AID557486 | Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID395346 | Antibacterial activity against Mycobacterium smegmatis CCM 2067 at 10 units after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID531417 | Antibacterial activity against Streptococcus pneumoniae serotype 19A by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID495797 | Activity at Pseudomonas fluorescens PF-1 beta-lactamase BIC-1 expressed in Escherichia coli DH10B carrying pSau1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID1279014 | Antibacterial activity against Enterococcus sp. J 14365/08 after 48 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. |
| AID508301 | Inhibition of PBP6 in penicillin-resistant Enterococcus faecium D63r membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID557525 | Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID163788 | In vitro antimicrobial activity against Pseudomonas aeruginosa 1101-75 was determined | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Design, synthesis, and SAR of novel carbapenem antibiotics with high stability to Xanthomonas maltophilia oxyiminocephalosporinase type II. |
| AID1254300 | Antibacterial activity against methicillin-resistant Staphylococcus aureus H 5996/08 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID368495 | Ratio of Kcat to Km of Escherichia coli CTX-M-15 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1474167 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID522660 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis BA1086 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID568434 | Antimicrobial activity against Staphylococcus epidermidis MTCC 437 after 24 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Stereoselective first total synthesis, confirmation of the absolute configuration and bioevaluation of botryolide-E. |
| AID1454341 | Antibacterial activity Staphylococcus aureus MTCC 96 by agar well method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis and biological evaluation of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thioglycosides. |
| AID571183 | Antibacterial activity against Neisseria gonorrhoeae harboring wild-type ponA gene by disk agar diffusion method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID522644 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis SK57 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID554860 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 143 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID530521 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 8607-03 expressing pbp2x Q557E mutant and harboring empty vector by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID375912 | Antibacterial activity against multi-drug resistant Staphylococcus aureus BAA-39 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents. |
| AID524672 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing beta-lactamase TEM-1 mutant gene assessed as percentage intermediate isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID533927 | Antimicrobial activity against Staphylococcus aureus 1651 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID210365 | In vitro antibacterial activity against the gram-positive bacteria, penicillin resistant Streptococcus pneumoniae (4636) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7 | New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID495725 | Activity of Klebsiella pneumoniae KPC-2 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID770970 | Antibacterial activity against Pseudomonas aeruginosa MTCC 741 by broth dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Demonic axe-like conjugated alkynes in combating microbes. |
| AID524643 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing penA and mtrR mutant gene assessed as incidence of susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID1091747 | Antibacterial activity against Staphylococcus aureus MTCC 96 assessed as inhibition zones at 100 ug/disc at 37 degC for 24 hr | 2009 | Chemical & pharmaceutical bulletin, Jul, Volume: 57, Issue:7 | Synthesis, nematicidal and antimicrobial properties of Bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2H-pyrazolo[3,4-d]thiazol-5-yl]phenyl]methanes. |
| AID520384 | Antimicrobial activity Escherichia coli DH5alpha expressing beta lactamase VIM-2 by agar macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID665397 | Antibacterial activity against Escherichia coli MTCC 42 after 24 hrs by serial dilution technique | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Synthesis, characterization, antimicrobial activities and QSAR studies of some 10a-phenylbenzo[b]indeno[1,2-e][1,4]thiazin-11(10aH)-ones. |
| AID1254298 | Antibacterial activity against Staphylococcus aureus CCM 4516/08 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. |
| AID278522 | Antimicrobial activity against Bifidobacterium bifidum R0071 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID295113 | Antibacterial activity against Mycobacterium smegmatis CCM 2067 at 10 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID559701 | Antimicrobial activity against Bacillus subtilis AB91021 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID372898 | Antibacterial activity against sPseudomonas aeruginosa ATCC 13525 after 24 hrs by MTT assay | 2009 | European journal of medicinal chemistry, Apr, Volume: 44, Issue:4 | Synthesis, characterization and structure-activity relationship analysis of novel depsides as potential antibacterials. |
| AID540213 | Half life in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID529660 | Ratio of Kcat to Km for Pseudomonas aeruginosa COL-1 beta-lactamase VIM-2 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID535645 | Antimicrobial activity against Group B Streptococcus serotype Ia N1 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID573795 | Antibacterial activity against Prevotella buccae assessed as susceptible isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID625281 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID524058 | Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP2a by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID1653047 | Antibacterial activity against Staphylococcus aureus | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Isatin derivatives and their anti-bacterial activities. |
| AID511445 | Antimicrobial activity against Streptococcus uberis ATCC 9529 harboring PBP2B N366I/T402I and PBP2X E381K/Q554E mutation assessed as inhibition of visible growth by broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. |
| AID258713 | Antibacterial activity against gram negative Pseudomonas aeruginosa (MTCC 741) | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1 | Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents. |
| AID562580 | Antimicrobial activity against Streptococcus Group C clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID398238 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium 379 after 18 hrs by twofold serial microbroth dilution method | 2003 | Journal of natural products, Dec, Volume: 66, Issue:12 | A novel antibacterial iridoid and triterpene from Caiophora coronata. |
| AID495707 | Kcat/Km ratio of Pseudomonas aeruginosa AmpC | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID562585 | Antimicrobial activity against erythromycin-susceptible Streptococcus agalactiae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID587970 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 N104D mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID1454340 | Antibacterial activity Bacillus subtilis MTCC 441 by agar well method | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15 | Synthesis and biological evaluation of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thioglycosides. |
| AID278682 | Antibacterial activity against Enterococcus faecium isolate 5753 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID1546651 | Antibacterial activity against Klebsiella pneumoniae MTCC 618 assessed as reduction in microbial growth after 24 hrs by CLSI based microdilution method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1 | Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents. |
| AID588106 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB A121S mutant gene, PBP1 L421P mutant gene, PBP2 XXXVIII pattern, deletion of nucleotide A from mtrA promoter, MAST 3116 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID307355 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 24 hrs by broth dilution assay | 2007 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 17, Issue:12 | Penicillin-bound polyacrylate nanoparticles: restoring the activity of beta-lactam antibiotics against MRSA. |
| AID498367 | Antimicrobial activity against wild type streptomycin-susceptible Streptococcus gordonii assessed as bacterial count at 2 ug/ml after 24 hrs by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | A single mutation in enzyme I of the sugar phosphotransferase system confers penicillin tolerance to Streptococcus gordonii. |
| AID1054722 | Antibacterial activity against Bacillus cereus Frankland and Frankland ATCC 11778 after overnight incubation by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Pahangensin A and B, two new antibacterial diterpenes from the rhizomes of Alpinia pahangensis Ridley. |
| AID498370 | Antimicrobial activity against erythromycin- and streptomycin-resistant Streptococcus gordonii Tol1 harboring R483P mutation in ptsI assessed as bacterial count at 2 ug/ml after 24 hrs by macrodilution technique | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | A single mutation in enzyme I of the sugar phosphotransferase system confers penicillin tolerance to Streptococcus gordonii. |
| AID1237603 | Antibacterial activity against Staphylococcus aureus ATCC25923 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID341349 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 111 allele encoding PBP2 P551 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID206811 | In vitro Minimum inhibitory concentration against Staphylococcus penicillin G resistant) | 1981 | Journal of medicinal chemistry, Oct, Volume: 24, Issue:10 | Synthesis and evaluation of ureido- and vinylureidopenicillins as inhibitors of intraruminal lactic acid production. |
| AID405085 | Ratio of Kcat to Km of Citrobacter freundii PER2 beta lactamase | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID1064522 | Antibacterial activity against Staphylococcus epidermidis H 6966/08 after 24 hrs by microdilution broth method | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2 | Alkylamino derivatives of pyrazinamide: synthesis and antimycobacterial evaluation. |
| AID532989 | Antibacterial activity against Klebsiella aerogenes NCIM 2281 in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | |||
| AID1191522 | Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates. |
| AID351192 | Elimination half life in preterm neonates with septicemia or invasive infections with gestational age of less than 32 weeks at 50000 U/kg, iv administered every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks. |
| AID375916 | Antibacterial activity against Streptococcus pneumoniae ATCC 6301 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents. |
| AID573151 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID171122 | Concentration of compound in rat brain after intravenous injection of 20 mg/kg benzyl-penicillin after 40 min; Below detection limit. | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID351191 | Volume of distribution at steady state in preterm neonates with septicemia or invasive infections with gestational age of less than 32 weeks at 50000 U/kg, iv administered every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks. |
| AID378413 | Antimicrobial activity against Penicillium griseofulvum DSM 847 after 24 hrs | 2006 | Journal of natural products, Aug, Volume: 69, Issue:8 | Carneic acids A and B, chemotaxonomically significant antimicrobial agents from the xylariaceous ascomycete Hypoxylon carneum. |
| AID530520 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype V isolate 9171-03 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | |||
| AID530522 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 8607-03 expressing pbp2x Q557E mutant and harboring plasmid expressing wild-type pbp2x by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID561252 | Antibacterial activity against Streptococcus pneumoniae assessed as resistant isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID1778129 | Antimicrobial activity against Pseudomonas aeruginosa assessed as microbial growth inhibition by CLSI-protocol based broth microdilution assay | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4 | Opportunities and Limitations for Assigning Relative Configurations of Antibacterial Bislactones using GIAO NMR Shift Calculations. |
| AID530511 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 7507-03 expressing pbp2x Q557E mutant and multilocus sequence type ST19 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID293928 | Growth inhibition against penicillin-susceptible Staphylococcus ATCC 25923 aureus after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6 | N-thiolated beta-lactams: Studies on the mode of action and identification of a primary cellular target in Staphylococcus aureus. |
| AID625531 | Antimicrobial activity against Klebsiella pneumoniae MTCC 618 by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Iodine-catalyzed conjugate addition of indoles onto en-1,4-dione: a novel synthesis of 3-(1-(1H-indol-3-yl)-2-oxo-2-phenylethyl)indolin-2-ones as antibacterial and antifungal agents. |
| AID495743 | Kcat/Km ratio of Pseudomonas aeruginosa IMP-1 relative to Cephaloridine | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID560701 | Ratio of Kcat to Km for Escherichia coli MC4100 Beta-Lactamase CMY-30 harboring Val211?Gly211 mutation | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID575080 | Antimicrobial activity against Streptococcus pneumoniae serotype 11A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1474166 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID634234 | Antibacterial activity against Prevotella intermedia ATCC 25611 assessed as growth inhibition at 0.00625 to 2.5 ug/ml ug/ml after 24 hrs by microplate dilution assay | 2011 | Journal of natural products, Dec-27, Volume: 74, Issue:12 | Isoflavonoids and coumarins from Glycyrrhiza uralensis: antibacterial activity against oral pathogens and conversion of isoflavans into isoflavan-quinones during purification. |
| AID529902 | Antimicrobial activity against Leptospira interrogans serovar Pomona isolate 12 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID533944 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis 1172 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID524060 | Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP2a by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID395342 | Antibacterial activity against Klebsiella pneumoniae UC57 at 10 units after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID278533 | Antimicrobial activity against Bifidobacterium breve R0070 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID525545 | Antimicrobial activity against Haemophilus influenzae Rd KW20 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID535644 | Antimicrobial activity against Group B streptococcus serotype Ib N2 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID617970 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino) phenyl-N'-phenyl-thiourea. |
| AID1765573 | Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID524649 | Antimicrobial activity against Neisseria gonorrhoeae obtained from patient with uncomplicated gonorrhea expressing beta-lactamase TEM-1 mutant gene assessed as incidence of susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. |
| AID573147 | Antibacterial activity against penicillin-nonsusceptible Streptococcus viridans assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1243292 | Antimicrobial activity against ciprofloxacin-resistant Escherichia coli clinical isolates by standard broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Synthesis and biological evaluation of levofloxacin core-based derivatives with potent antibacterial activity against resistant Gram-positive pathogens. |
| AID530516 | Antimicrobial activity against group B Streptococcus sp. 'group B' isolate 7368-04 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID587972 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 D240S mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID368726 | Activity of Serratia marcescens AmpC assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID521344 | Antimicrobial activity against Streptococcus pneumoniae ATCC BAA-343 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID519746 | Activity of Klebsiella pneumoniae Beta-Lactamase SHV-1 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID542620 | Antimicrobial activity against streptomycin-resistant Streptococcus pneumoniae R6 harboring PBP2x T338G mutant gene and Janus disruption at PBP1a after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID1755806 | Antibacterial activity against Pseudomonas aeruginosa ATCC 13525 incubated for 24 hrs by two fold serial dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID490133 | Antibacterial activity against Pseudomonas aeruginosa ATCC 13525 after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents. |
| AID448316 | Antibacterial activity against Escherichia coli by broth dilution method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, photochemical E (trans)-->Z (cis) isomerization and antimicrobial activity of 2-chloro-5-methylpyridine-3-olefin derivatives. |
| AID546209 | Antimicrobial activity against Staphylococcus aureus 2171 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Identification of the novel dfrK-carrying transposon Tn559 in a porcine methicillin-susceptible Staphylococcus aureus ST398 strain. |
| AID611679 | Antibacterial activity against Bacillus megaterium at 0.05 mg by agar diffusion method | 2011 | Journal of natural products, Jul-22, Volume: 74, Issue:7 | Bioactive 11,20-epoxy-3,5(16)-diene briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. |
| AID1161137 | Antimicrobial activity against Staphylococcus aureus after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID356757 | Antimicrobial activity against Enterococcus faecium 436 after 18 hrs by microbroth dilution method | 2001 | Journal of natural products, Jul, Volume: 64, Issue:7 | Biological and mechanistic activities of xanthorrizol and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol isolated from Iostephane heterophylla. |
| AID43582 | Inhibition constant (Ki) for TEM-1 beta-lactamase | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | N-aryl 3-halogenated azetidin-2-ones and benzocarbacephems, inhibitors of beta-lactamases. |
| AID508305 | Inhibition of PBP4 in wild type Enterococcus faecium D63 membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID1638897 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC BAA-41 measured after 18 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action. |
| AID528708 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID171124 | Concentration of compound in rat brain after intravenous injection of 20 mg/kg benzyl-penicillin after 5 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID374683 | Antimicrobial activity against kanamycin-resistant Escherichia coli K-12 M1 W3110 deltarapA mutant 24 hrs biolflim at 350 ug/ml after 1 hr by microtiter plate count method | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID431308 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis and structure-activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents. |
| AID368535 | Activity of Providencia stuartii AmpC assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID529333 | Antibacterial activity against penicillin-cefotaxime- ceftriaxone-resistant Streptococcus pneumoniae serotype 14 URA3043 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID588114 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates assessed as percent susceptible isolates after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID603191 | Antibacterial activity against Staphylococcus epidermidis MTCC 2639 by broth microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 21, Issue:13 | Efficient synthesis, structural characterization and anti-microbial activity of chiral aryl boronate esters of 1,2-O-isopropylidene-α-D-xylofuranose. |
| AID558623 | Antimicrobial activity against Streptococcus pneumoniae isolate 3412 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID563975 | Ratio of Kcat to Km for Klebsiella pneumoniae 05-560 beta-lactamase IMP1 | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID1348088 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID1180446 | Antimicrobial activity against Staphylococcus aureus CCM 4516/08 after 48 hrs by microdilution method | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates. |
| AID1309201 | Antibacterial activity against Agrobacterium tumefaciens by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Four new minor brominated indole related alkaloids with antibacterial activities from Laurencia similis. |
| AID508296 | Inhibition of PBP2 in penicillin-resistant Enterococcus faecium D63r membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID558601 | Antimicrobial activity against Streptococcus pneumoniae isolate 24 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID577454 | Inhibition of Streptococcus pneumoniae isolate 8882 Bocillin FL binding to PBP2b 443SSNA mutant | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID546432 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-3 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID681390 | TP_TRANSPORTER: uptake in Oat3-expressing LLC-PK1 cells | 2002 | Molecular pharmacology, May, Volume: 61, Issue:5 | Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. |
| AID418561 | Antibacterial activity against Bacillus subtilis ATCC 23857 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5 | Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents. |
| AID524055 | Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID678811 | TP_TRANSPORTER: uptake in Xenopus laevis oocytes | 1999 | The Journal of pharmacology and experimental therapeutics, May, Volume: 289, Issue:2 | Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. |
| AID375922 | Antibacterial activity against Clostridium perfringens ATCC 10388 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents. |
| AID689077 | Antibacterial activity against Bacillus megaterium assessed as zone of inhibition at 0.05 mg by agar diffusion method | 2012 | Journal of natural products, Sep-28, Volume: 75, Issue:9 | Sinularosides A and B, bioactive 9,11-secosteroidal glycosides from the South China Sea soft coral Sinularia humilis Ofwegen. |
| AID451359 | Antimicrobial activity against Penicillium expansum NBRC8800 after 24 hrs by broth dilution method | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. |
| AID1437659 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 25923 after 20 to 24 hrs by two-fold microdilution method | |||
| AID563977 | Ratio of Kcat to Km for Klebsiella pneumoniae 05-560 beta-lactamase VIM2 | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID495695 | Activity of Klebsiella pneumoniae KPC-2 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. |
| AID573601 | Antibacterial activity against Fusobacterium necrophorum assessed as resistant isolates by CLSI agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID773427 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700787 by microdilution technique | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20 | The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds. |
| AID442477 | Antibacterial activity against Bacillus subtilis MTCC 441 by broth dilution method | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1 | Click chemistry: studies on the synthesis of novel fluorous tagged triazol-4-yl substituted quinazoline derivatives and their biological evaluation--theoretical and experimental validation. |
| AID428127 | Antimicrobial activity against penicillin-resistant Streptococcus gordonii PR1_2 mutant | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory. |
| AID528706 | Antibacterial activity against Streptococcus agalactiae group B clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID529322 | Antibacterial activity against Streptococcus pneumoniae serotype 22 URA2542 harboring PBP2B harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID520399 | Antibacterial activity against mef and erm(B) positive Streptococcus pneumoniae isolates assessed as resistance incidence by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID447061 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 10 IU after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID592681 | Apparent permeability across human Caco2 cell membrane after 2 hrs by LC-MS/MS analysis | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8 | QSAR-based permeability model for drug-like compounds. |
| AID406550 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as inhibition zone diameter at 20 ug after 2 hrs by Kirby-Bauer test | 2008 | Bioorganic & medicinal chemistry, Jul-01, Volume: 16, Issue:13 | Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis. |
| AID278564 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum ATCC 15708 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID561250 | Antibacterial activity against Streptococcus pneumoniae assessed as susceptible isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID571176 | Antibacterial activity against Neisseria gonorrhoeae by disk agar diffusion method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. |
| AID559512 | Antibacterial activity against Lancefield Streptococcus sp. 'group G' assessed as percent susceptible isolates by CLSI M100-S18 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. |
| AID425652 | Total body clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID508297 | Inhibition of PBP3 in penicillin-resistant Enterococcus faecium D63r membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID203340 | Minimum inhibitory concentration against aerobic organism Shigella species strain 2880 | 1982 | Journal of medicinal chemistry, Apr, Volume: 25, Issue:4 | Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain. |
| AID1759750 | Binding affinity to Staphylococcus aureus ATCC 43300 50S ribosome assessed as dissociation rate constant by SPR analysis | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Design, synthesis and biological evaluation of novel pleuromutilin derivatives as potent anti-MRSA agents targeting the 50S ribosome. |
| AID1321392 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method | 2016 | Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19 | The Rational Design, Synthesis, and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine Kinases. |
| AID689078 | Antimicrobial activity against Chlorella fusca assessed as zone of inhibition at 0.05 mg by agar diffusion method | 2012 | Journal of natural products, Sep-28, Volume: 75, Issue:9 | Sinularosides A and B, bioactive 9,11-secosteroidal glycosides from the South China Sea soft coral Sinularia humilis Ofwegen. |
| AID572272 | Antimicrobial activity against Streptococcus pneumoniae ATCC 6301 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID1638905 | Antimicrobial activity against NDM1 beta-lactamase expressing Klebsiella pneumoniae ATCC BAA-2470 measured after 18 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action. |
| AID557503 | Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID609858 | Antimicrobial activity against Acinetobacter baumannii ATCC 15151 assessed as growth inhibition after 18 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Unprecedented C-2 arylation of indole with diazonium salts: Syntheses of 2,3-disubstituted indoles and their antimicrobial activity. |
| AID1348087 | Antimicrobial activity against Staphylococcus aureus subsp. aureus ATCC 25923 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID1237615 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC52056 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID1209730 | Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4 | Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. |
| AID368504 | Ratio of Kcat to Km of Klebsiella pneumoniae TEM26 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID494347 | Antibacterial activity against Staphylococcus epidermidis by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis, characterization and antimicrobial studies of 2-(4-methoxy-phenyl)-5-methyl-4-(2-arylsulfanyl-ethyl)-2,4-dihydro-[1,2,4] triazolo-3-ones and their corresponding sulfones. |
| AID575145 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate NRS71 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID524069 | Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID575420 | Antimicrobial activity against anrB-deficient Listeria monocytogenes EGD-e assessed as growth inhibition after 16 hrs by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics. |
| AID495915 | Ratio of Kcat to Km for beta-lactamase VIM-1 expressed in Escherichia coli TOP10 by spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID560706 | Inhibition of Escherichia coli MC4100 Beta-Lactamase CMY-2 using cephalothin as reporter substrate | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID1243290 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis clinical isolates by standard broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Synthesis and biological evaluation of levofloxacin core-based derivatives with potent antibacterial activity against resistant Gram-positive pathogens. |
| AID375917 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents. |
| AID278544 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium thermophilum ATCC 25866 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1209735 | Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake at 500 uM over 20 mins relative to untreated-control | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4 | Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. |
| AID522666 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis Texas 2 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID529656 | Ratio of Kcat to Km for Pseudomonas aeruginosa 9551 beta-lactamase VIM-15 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID559703 | Antimicrobial activity against Escherichia coli AB94012 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID521826 | Antimicrobial activity against Streptococcus pneumoniae isolated from patient with bacterial infection by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID1505254 | Antibacterial activity against Staphylococcus aureus 155554A incubated for 16 hrs by microdilution assay | 2018 | ACS medicinal chemistry letters, Jan-11, Volume: 9, Issue:1 | Disconnecting the Estrogen Receptor Binding Properties and Antimicrobial Properties of Parabens through 3,5-Substitution. |
| AID1347488 | Antibacterial activity against Staphylococcus aureus assessed as zone of inhibition after 24 to 48 hrs by well diffusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations. |
| AID322504 | Volume of distribution at steady state in human very low birth weight preterm neonates at 28 mg/kg, iv | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Pharmacokinetics of penicillin g in very-low-birth-weight neonates. |
| AID503229 | Ratio of MIC for penicillin-resistant Streptococcus pneumoniae 4790 to MIC for penicillin-sensitive Streptococcus pneumoniae R6 | 2007 | Nature chemical biology, Sep, Volume: 3, Issue:9 | Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. |
| AID425865 | Antimicrobial activity against Carnobacterium divergens BM4489 expressing beta-lactamase CAD1 at 0.5 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID662528 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 18 to 20 hrs by spectrophotometry | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12 | Discovery of potent antimicrobial peptide analogs of Ixosin-B. |
| AID532980 | Antibacterial activity against Escherichia coli DH5alpha in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID531607 | Ratio of Kcat to Km for Escherichia coli beta-lactamase SHV-11 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID562408 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID522642 | Antibacterial activity against beta-lactamase Bla1 and Bla2-producing Bacillus anthracis Vollum 1B by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. |
| AID508371 | Antibacterial activity against Streptococcus pneumoniae harboring erm(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID531606 | Ratio of Kcat to Km for Escherichia coli Inhibitor-resistant beta-lactamase SHV-56 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID554878 | Antimicrobial activity against Streptococcus pneumoniae serotype 10 ST 461 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID1348084 | Antimicrobial activity against Candida albicans ATCC 10231 assessed as zone of inhibition at 50 ug per disc after 48 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID171264 | Concentration of compound in rat lung after intravenous injection of 20 mg/kg benzyl-penicillin after 1 min | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats. |
| AID529329 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae serotype 19A URA5805 harboring mutant PBP2B PBP2X and PBP1A | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. |
| AID341531 | Antimicrobial activity against Neisseria meningitidis isolates harboring penA 17 allele encoding PBP2 mutant | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. |
| AID508307 | Inhibition of low-affinity PBP5fm in wild type Enterococcus faecium D63 membranes assessed as inhibition of fluorescent ampicillin binding after 20 mins at 37 degC | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. |
| AID1320836 | Activity of native signal containing Klebsiella pneumoniae OXA-48 assessed as ratio of Kcat to Km by Michaelis-Menten kinetics assay | 2016 | Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11 | Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening. |
| AID1546650 | Antibacterial activity against Pseudomonas aeruginosa MTCC 741 assessed as reduction in microbial growth after 24 hrs by CLSI based microdilution method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1 | Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents. |
| AID539695 | Antifungal activity against Klebsiella pneumoniae MTCC 618 by broth dilution method | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | Indium(III) chloride catalyzed three-component coupling reaction: a novel synthesis of 2-substituted aryl(indolyl)kojic acid derivatives as potent antifungal and antibacterial agents. |
| AID681152 | TP_TRANSPORTER: uptake in Xenopus laevis oocytes | 2002 | Drug metabolism and pharmacokinetics, , Volume: 17, Issue:4 | Transporter-mediated Drug Interactions. |
| AID531420 | Antibacterial activity against Streptococcus pneumoniae serotype 19F by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID1802450 | Oatp1d1 Transport Assay from Article 10.1074/jbc.M113.518506: \\Molecular characterization of zebrafish Oatp1d1 (Slco1d1), a novel organic anion-transporting polypeptide.\\ | 2013 | The Journal of biological chemistry, Nov-22, Volume: 288, Issue:47 | Molecular characterization of zebrafish Oatp1d1 (Slco1d1), a novel organic anion-transporting polypeptide. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5986 (66.77) | 18.7374 |
| 1990's | 1051 (11.72) | 18.2507 |
| 2000's | 914 (10.20) | 29.6817 |
| 2010's | 868 (9.68) | 24.3611 |
| 2020's | 146 (1.63) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (88.91) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 353 (3.70%) | 5.53% |
| Reviews | 397 (4.16%) | 6.00% |
| Case Studies | 1,459 (15.30%) | 4.05% |
| Observational | 10 (0.10%) | 0.25% |
| Other | 7,316 (76.73%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Follow-up Study for Patients Who Participated in the GOAL Trial (GOAL-Post) [NCT05211024] | 1,102 participants (Anticipated) | Observational | 2022-01-28 | Active, not recruiting | |||
| Treatment of Pharyngitis Study (TOPS): A Randomized Equivalence Trial of Intramuscular Penicillin G vs. Oral Amoxicillin Antibiotics for the Treatment of Streptococcal Pharyngitis in Children in Developing Countries [NCT01156740] | 558 participants (Actual) | Interventional | 2001-08-31 | Completed | |||
| Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis in Non-pregnant Women [NCT03752112] | Phase 1/Phase 2 | 180 participants (Anticipated) | Interventional | 2019-11-22 | Recruiting | ||
| Single-dose Azithromycin Versus Penicillin G Benzathine for the Treatment of Yaws in Children [NCT01382004] | Phase 3 | 255 participants (Actual) | Interventional | 2010-09-30 | Completed | ||
| Clinical Trial Comparing the Effectiveness of Cefixime Versus Penicillin G for Treatment of Early Syphilis [NCT04958122] | Phase 3 | 400 participants (Anticipated) | Interventional | 2021-06-20 | Recruiting | ||
| Prospective Randomized Study to Compare Clinical Outcomes in Patients With Osteomyelitis Treated With Intravenous Antibiotics Versus Intravenous Antibiotics With an Early Switch to Oral Antibiotics [NCT02099240] | Early Phase 1 | 11 participants (Actual) | Interventional | 2014-03-06 | Terminated(stopped due to Not enough patient enrollment and lack of staffing) | ||
| First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition [NCT03174236] | Phase 3 | 2,000 participants (Anticipated) | Interventional | 2017-09-04 | Active, not recruiting | ||
| A Phase 1, Open-label Study To Investigate The Pharmacokinetics And Safety Of A Single Intramuscular Injection Of Benzathine Benzylpenicillin In Japanese Healthy Subjects [NCT03612557] | Phase 1 | 8 participants (Actual) | Interventional | 2018-08-20 | Completed | ||
| Treatment Responses of Early Syphilis to Single-dose Ceftriaxone Plus Doxycycline Versus Single-dose Benzathine Penicillin G Plus Doxycycline in PLWH [NCT05980871] | Phase 4 | 300 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| Therapeutic Drug Monitoring and Continuous Infusion of Beta-lactam Antibiotics in Patients With Bacteraemia [NCT03108690] | Phase 4 | 0 participants (Actual) | Interventional | 2017-10-01 | Withdrawn(stopped due to Logistics) | ||
| [NCT02871505] | Phase 4 | 150 participants (Anticipated) | Interventional | 2016-08-31 | Recruiting | ||
| A Multi-centre Study to Define Novel Individualised Dosing Regimens to Maximise Antibiotic Effectiveness for Treatment of Pneumonia in Intensive Care Units [NCT04986254] | 80 participants (Anticipated) | Observational | 2019-10-17 | Recruiting | |||
| Closed-loop Control of Penicillin Delivery Integrating Electrochemical Biosensor Technology [NCT04053140] | Phase 1 | 20 participants (Anticipated) | Interventional | 2019-11-05 | Recruiting | ||
| Clinical Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis [NCT03660488] | Phase 2 | 58 participants (Actual) | Interventional | 2018-09-03 | Completed | ||
| Comparison of Intravenous Co-amoxiclav Versus Benzyl Penicillin in Children With Severe Tonsillitis [NCT04215770] | 310 participants (Actual) | Interventional | 2018-01-01 | Completed | |||
| Once-daily Therapy for Streptococcal Pharyngitis [NCT01310361] | Phase 1 | 0 participants | Interventional | 2004-01-31 | Completed | ||
| Procalcitonin as a Marker of Antibiotic Therapy in Patients With Lower Respiratory Tract Infections. Can Measurement of Procalcitonin Reduce the Use of Antibiotics? [NCT02171338] | Phase 4 | 55 participants (Anticipated) | Interventional | 2013-10-31 | Active, not recruiting | ||
| Simplified Antibiotic Regimens for the Management of Sepsis in Young Infants in First-level Facilities: Randomized Controlled Trial [NCT01027429] | Phase 3 | 2,543 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| Supportive Care and Antibiotics for Severe Pneumonia Among Hospitalized Children [NCT04041791] | Phase 3 | 4,392 participants (Anticipated) | Interventional | 2019-08-19 | Recruiting | ||
| Doctor of Medicine [NCT02857959] | Phase 4 | 150 participants (Anticipated) | Interventional | 2016-08-31 | Recruiting | ||
| Randomized Controlled Trial of Intramuscular Ceftriaxone Versus Procaine Penicillin Versus Cotrimoxazole and Gentamicin for Management of Serious Bacterial Infections in Young Infants in Community Settings [NCT00189384] | Phase 3 | 426 participants | Interventional | 2003-11-30 | Active, not recruiting | ||
| Validate an Easy to Administer Algorithm to Define Penicillin (PCN-B-lactam) Allergy Status in Sexually Transmitted Disease (STD) Clinic Outpatients [NCT04620746] | Phase 4 | 284 participants (Actual) | Interventional | 2021-06-01 | Completed | ||
| Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus (Relais Oral Dans le Traitement Des Endocardites à Streptocoques Multi-sensibles) [NCT02701595] | Phase 3 | 324 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | ||
| Randomized, Clinical Trial to Compare the Serological Response Rates of Serofast Early Syphilis Cases Retreated With Three Doses Benzathine Penicillin and Absence of Any Retreatment [NCT02884115] | Phase 4 | 150 participants (Anticipated) | Interventional | 2016-08-31 | Recruiting | ||
| A Pilot Study Evaluating Penicillin G and Ceftriaxone as Therapies for Presumed Neurosyphilis in HIV Seropositive Individuals [NCT00000648] | 100 participants | Interventional | Completed | ||||
| Comparisons of Treatment Responses of Early Syphilis to 2.4 Milliunits (MU) Single-dose Benzathine Penicillin G With or Without Doxycycline in People Living With HIV [NCT06069141] | 688 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | |||
| A Phase 4 Comparative Trial of Benzathine Penicillin G 2.4 Million Units Administered as a Single Dose Versus Three Successive Weekly Doses for Treatment of Early Syphilis in Subjects With or Without HIV Infection [NCT03637660] | Phase 4 | 249 participants (Actual) | Interventional | 2018-10-31 | Completed | ||
| A Phase III Equivalence Trial of Azithromycin vs. Benzathine Penicillin for the Treatment of Early Syphilis [NCT00031499] | Phase 3 | 593 participants (Actual) | Interventional | 2000-06-30 | Completed | ||
| Pilot Randomised Controlled Trial of Penicillin Versus Flucloxacillin for Definitive Treatment of Invasive Penicillin Susceptible Staphylococcus Aureus [NCT03632642] | Phase 4 | 0 participants (Actual) | Interventional | 2019-07-01 | Withdrawn(stopped due to Study never commenced) | ||
| CHOICE UTI - Clinical Efficacy of Single Dose (Daily) IV Antibiotics Followed by 2 Days Oral Antibiotics Compared to 3 Doses (Daily) IV Antibiotics for Children With Complicated Urinary Tract Infections: a Multicentre Randomised Trial [NCT04876131] | Phase 4 | 452 participants (Anticipated) | Interventional | 2022-05-30 | Recruiting | ||
| Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent Rheumatic Heart Disease: A Non-inferiority Randomized Trial [NCT05693545] | Phase 2 | 1,004 participants (Anticipated) | Interventional | 2023-09-01 | Recruiting | ||
| Syphilis Response to Higher Penicillin Dosage in HIV Co-Infected Patients [NCT02611765] | Phase 4 | 64 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| Amoxicillin Versus Benzyl Penicillin for Severe Childhood Pneumonia Amongst Inpatients: An Open Label Randomised Controlled Non-inferiority Trial [NCT01399723] | Phase 3 | 561 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| Staphylococcus Aureus Network Adaptive Platform Trial [NCT05137119] | Phase 4 | 6,000 participants (Anticipated) | Interventional | 2022-02-16 | Recruiting | ||
| Confirmatory Study to Examine Negative Predictive Value (NPV) and Safety of Skin Testing With PRE-PEN, a Minor Determinant MIxture (MDM) of Penicillin Antigens, and Amoxicillin Reagent Against an Oral Challenge With Amoxicillin [NCT01818336] | Phase 3 | 481 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| The GOAL (GwokO Adunu pa Lutino) Trial: Determining the Impact of Penicillin on Latent Rheumatic Heart Disease: A Randomized Controlled Trial in Uganda [NCT03346525] | Phase 2 | 807 participants (Actual) | Interventional | 2018-06-26 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||