Proteins > P2Y purinoceptor 2
Page last updated: 2024-08-07 16:37:44

P2Y purinoceptor 2

A P2Y purinoceptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41231]

Synonyms

P2Y2;
ATP receptor;
P2U purinoceptor 1;
P2U1;
P2U receptor 1;
Purinergic receptor

Research

Bioassay Publications (30)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's17 (56.67)29.6817
2010's12 (40.00)24.3611
2020's1 (3.33)2.80

Compounds (28)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
suraminHomo sapiens (human)IC5050.000011
trypan blueHomo sapiens (human)IC50171.000011
suramin sodiumHomo sapiens (human)IC50100.000011
a 803467Homo sapiens (human)IC5010.000011
acid blue 40Homo sapiens (human)IC505.810011
acid blue 25Homo sapiens (human)IC5011.177544

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acidHomo sapiens (human)EC5010.000011
suraminHomo sapiens (human)EC5048.000011
adenosine diphosphateHomo sapiens (human)EC50100.000011
uridine diphosphateHomo sapiens (human)EC5042.166733
adenosine monophosphateHomo sapiens (human)EC501.892512
uridine triphosphateHomo sapiens (human)EC508.26824040
cytidine triphosphateHomo sapiens (human)EC5037.780011
uridine diphosphate glucoseHomo sapiens (human)EC5010.000011
diadenosine tetraphosphateHomo sapiens (human)EC5086.56811313
deoxyuridine triphosphateHomo sapiens (human)EC501.080011
methylthio-adpHomo sapiens (human)EC50100.000011
diquafosolHomo sapiens (human)EC5074.55891616
phosphoribofuranosylbarbituric acidHomo sapiens (human)EC50100.000011
2-chloro-atpHomo sapiens (human)EC502.300011
uridine 5'-tetraphosphateHomo sapiens (human)EC503.255022
adenosine 5'-o-(3-thiotriphosphate)Homo sapiens (human)EC501.720022
TTPHomo sapiens (human)EC500.480011
4-thiouridine triphosphateHomo sapiens (human)EC500.368022
5-bromouridine triphosphateHomo sapiens (human)EC500.844244
denufosol tetrasodiumHomo sapiens (human)EC500.210033
denufosol tetrasodiumHomo sapiens (human)EC500.200011
5-fluorouridine 5'-triphosphateHomo sapiens (human)EC506.000011
4-thiouridylic acidHomo sapiens (human)EC50100.000011

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
signaling receptor activitymolecular functionReceiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling]
G protein-coupled purinergic nucleotide receptor activitymolecular functionCombining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah, PMID:9755289]
A1 adenosine receptor bindingmolecular functionBinding to an A1 adenosine receptor. [GOC:mah, GOC:nln]
G protein-coupled UTP receptor activitymolecular functionCombining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP. [GOC:mah]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 7 target(s):

TargetCategoryDefinition
intracellular monoatomic ion homeostasisbiological processA homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:mah]
phospholipase C-activating G protein-coupled receptor signaling pathwaybiological processA G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
G protein-coupled purinergic nucleotide receptor signaling pathwaybiological processA G protein-coupled receptor signaling pathway initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:BHF, PMID:9755289]
positive regulation of mucus secretionbiological processAny process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. [GOC:add]
cellular response to ATPbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. [GOC:mah]
blood vessel diameter maintenancebiological processAny process that modulates the diameter of blood vessels. [GOC:pr]
G protein-coupled receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]