levuglandin-e2 has been researched along with Necrosis* in 1 studies
1 other study(ies) available for levuglandin-e2 and Necrosis
Article | Year |
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Brain tissue injury and blood-brain barrier opening induced by injection of LGE2 or PGE2.
The hypothesis that the accumulation of prostaglandin (PG)E2 during reperfusion of severely ischemic tissue contributes to a breakdown in the blood-brain barrier (BBB) was expanded to include a parallel role for levuglandins(LGs), gamma-ketoaldehydes produced by rearrangement of PGH2. LGE2 was shown to be more potent than PGE2 in causing breakdown of the BBB when injected intrahemispherically. Brain tissue necrosis was clearly evident with total doses of levuglandin as low as 100 nmole. Topics: Animals; Blood-Brain Barrier; Body Water; Brain; Brain Edema; Dinoprostone; Evans Blue; Female; Male; Necrosis; Prostaglandins E; Rats | 1992 |