NPC1-like intracellular cholesterol transporter 1

An NPC1-like intracellular cholesterol transporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHC9]

Synonyms

Niemann-Pick C1-like protein 1

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (33.33)	29.6817
2010's	1 (33.33)	24.3611
2020's	1 (33.33)	2.80

Compounds (11)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ezetimibe	Homo sapiens (human)	IC50	0.3700	1	1
sch 60663	Homo sapiens (human)	IC50	0.3000	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
dehydroepiandrosterone	Homo sapiens (human)	EC50	10.0000	1	1
25-hydroxycholesterol	Homo sapiens (human)	EC50	3.3000	1	1
7-ketocholesterol	Homo sapiens (human)	EC50	8.7000	1	1
cholestane-3,5,6-triol, (3beta, 5alpha, 6beta)-isomer	Homo sapiens (human)	EC50	1.7000	1	1
6-ketocholestanol	Homo sapiens (human)	EC50	3.4000	1	1
ys 64	Homo sapiens (human)	EC50	1.7000	1	1
22s-hydroxycholesterol	Homo sapiens (human)	EC50	2.9000	1	1
cholest-5-en-3 beta,7 alpha-diol, (3beta,7beta)-isomer	Homo sapiens (human)	EC50	3.4000	1	1
cholenic acid dimethylamide	Homo sapiens (human)	EC50	3.1000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
vitamin E binding	molecular function	Binding to a vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. [ISBN:0721662544]
cholesterol binding	molecular function	Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:jl, ISBN:0198506732]
small GTPase binding	molecular function	Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782]
myosin V binding	molecular function	Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
cytoplasmic vesicle membrane	cellular component	The lipid bilayer surrounding a cytoplasmic vesicle. [GOC:mah]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 8 target(s):

Target	Category	Definition
cholesterol biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:ai]
intestinal cholesterol absorption	biological process	Uptake of cholesterol into the blood by absorption from the small intestine. [GOC:mah]
cholesterol transport	biological process	The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah, ISBN:0198506732]
lipoprotein metabolic process	biological process	The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. [ISBN:0198506732]
vitamin E metabolic process	biological process	The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. [GOC:jl, ISBN:0198506732]
vitamin transport	biological process	The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:ai]
cellular response to sterol depletion	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [GOC:mah]
cholesterol homeostasis	biological process	Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators]