Indoleamine 2,3-dioxygenase 1

An indoleamine 2,3-dioxygenase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14902]

Synonyms

IDO-1;
EC 1.13.11.52;
Indoleamine-pyrrole 2,3-dioxygenase

Research

Bioassay Publications (65)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (9.23)	29.6817
2010's	46 (70.77)	24.3611
2020's	13 (20.00)	2.80

Compounds (88)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tryptamine	Homo sapiens (human)	Ki	158.0000	2	2
oxyquinoline	Homo sapiens (human)	IC50	750.0000	1	1
bay h 4502	Homo sapiens (human)	IC50	23.0000	1	1
dichlorophen	Homo sapiens (human)	IC50	70.0000	1	1
benzophenone	Homo sapiens (human)	IC50	1,000.0000	1	1
ebselen	Homo sapiens (human)	Ki	0.0940	3	3
econazole	Homo sapiens (human)	IC50	4.6000	2	2
phenelzine	Homo sapiens (human)	IC50	14.0000	1	1
isoconazole	Homo sapiens (human)	IC50	23.0000	1	1
juglone	Homo sapiens (human)	IC50	1.0000	2	2
ketoconazole	Homo sapiens (human)	IC50	28.5000	2	2
beta-lapachone	Homo sapiens (human)	IC50	0.7200	4	4
beta-lapachone	Homo sapiens (human)	Ki	0.1000	2	2
vitamin k 3	Homo sapiens (human)	IC50	0.8925	4	4
miconazole	Homo sapiens (human)	IC50	3.7000	4	4
sulconazole	Homo sapiens (human)	IC50	6.4000	1	1
mitomycin	Homo sapiens (human)	Ki	25.0000	1	1
tryptophan	Homo sapiens (human)	IC50	498.7000	1	1
lawsone	Homo sapiens (human)	IC50	675.0000	1	1
3-hydroxy-2-naphthoic acid	Homo sapiens (human)	IC50	1,000.0000	1	1
benzotriazole	Homo sapiens (human)	IC50	2,570.0000	1	1
benzothiazole	Homo sapiens (human)	IC50	652.0000	1	1
phenylhydrazine	Homo sapiens (human)	IC50	0.5933	3	3
phenylhydroxylamine	Homo sapiens (human)	IC50	9.2000	1	1
4-aminodiphenylamine	Homo sapiens (human)	IC50	400.0000	1	1
4-chloroaniline	Homo sapiens (human)	IC50	1,553.0000	2	2
dichlone	Homo sapiens (human)	IC50	0.2800	2	2
dibenzothiazyl disulfide	Homo sapiens (human)	IC50	500.0000	1	1
1,4-naphthoquinone	Homo sapiens (human)	IC50	2.6860	5	5
9-fluorenone	Homo sapiens (human)	IC50	200.0000	1	1
benzohydroxamic acid	Homo sapiens (human)	IC50	16.0000	1	1
1,2-naphthoquinone	Homo sapiens (human)	IC50	7.1000	2	2
benzylhydrazine	Homo sapiens (human)	IC50	71.0000	1	1
1,4-naphthohydroquinone	Homo sapiens (human)	IC50	5.7500	2	2
2-hydrazinobenzothiazole	Homo sapiens (human)	IC50	35.1500	2	2
3-phenylpyridine	Homo sapiens (human)	IC50	161.0000	2	2
2-methoxy-1,4-naphthoquinone	Homo sapiens (human)	IC50	0.7200	2	2
6,7-Dimethyl-9-(2-acetoxyethyl)isoalloxazine	Homo sapiens (human)	IC50	515.6500	2	2
1-(2-(2,4-dichlorophenyl)-2-hydroxyethyl)-1h-imidazole	Homo sapiens (human)	IC50	130.0000	1	1
enilconazole	Homo sapiens (human)	IC50	23.0000	1	1
phenthiazamine	Homo sapiens (human)	IC50	1,000.0000	1	1
chaetochromin	Homo sapiens (human)	IC50	44.0900	1	1
norharman	Homo sapiens (human)	IC50	90.0000	1	1
norharman	Homo sapiens (human)	Ki	90.0600	2	2
sertaconazole	Homo sapiens (human)	IC50	6.1000	2	2
4-chlorophenethylamine	Homo sapiens (human)	IC50	60.0000	2	2
harmol	Homo sapiens (human)	IC50	2,000.0000	1	1
4(5)-phenylimidazole	Homo sapiens (human)	IC50	76.7824	17	17
4(5)-phenylimidazole	Homo sapiens (human)	Ki	4.4000	1	1
alpha-lapachone	Homo sapiens (human)	IC50	4.3400	2	2
xyloidone	Homo sapiens (human)	IC50	0.2140	2	2
chrysomycin a	Homo sapiens (human)	IC50	126.3000	2	2
tryptanthrine	Homo sapiens (human)	IC50	10,842.6107	5	3
tryptanthrine	Homo sapiens (human)	Ki	4.8100	2	1
fluoren-9-ol	Homo sapiens (human)	IC50	1,000.0000	1	1
2-phenylisatogen	Homo sapiens (human)	IC50	2.0567	3	3
4-nitrobenzyloxyamine	Homo sapiens (human)	IC50	2.7000	1	1
4-(2-thiazolylazo)resorcinol	Homo sapiens (human)	IC50	45.0400	1	1
1-methyltryptophan	Homo sapiens (human)	IC50	247.4225	4	4
1-methyltryptophan	Homo sapiens (human)	Ki	46.0000	6	7
2-phenylindolone	Homo sapiens (human)	IC50	114.0000	1	1
benzyloxyamine	Homo sapiens (human)	IC50	5.4050	2	2
4-hydroxycarbazole	Homo sapiens (human)	IC50	400.0000	1	1
cinnabarinic acid	Homo sapiens (human)	IC50	0.4600	1	1
cinnabarinic acid	Homo sapiens (human)	Ki	0.3260	1	1
celastrol	Homo sapiens (human)	IC50	8.4100	1	1
cryptotanshinone	Homo sapiens (human)	IC50	10.0000	1	1
tanshinone ii a	Homo sapiens (human)	IC50	10.0000	1	1
nsc 36398	Homo sapiens (human)	Ki	100.0000	1	1
Porfiromycine	Homo sapiens (human)	IC50	507.8500	2	2
6,11-dioxo-12-naphtho[2,3-b]indolizinecarboxylic acid ethyl ester	Homo sapiens (human)	IC50	0.3320	1	1
nsc228155	Homo sapiens (human)	IC50	66.0000	2	2
3-(1h-indol-3-yl)pyrrolidine-2,5-dione	Homo sapiens (human)	IC50	3.0000	1	1
indoximod	Homo sapiens (human)	IC50	15,198.9000	7	7
indoximod	Homo sapiens (human)	Ki	30.5000	4	4
5-amino-8-hydroxyquinoline	Homo sapiens (human)	IC50	3.0000	1	1
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	Homo sapiens (human)	IC50	0.5000	1	1
2-(3-Chloro-2-fluorophenyl)-2,3-dihydroisothiazol-3-one	Homo sapiens (human)	IC50	71.9333	3	3
tenatoprazole	Homo sapiens (human)	IC50	100.0000	1	1
1-methyltryptophan	Homo sapiens (human)	IC50	158.7535	22	20
1-methyltryptophan	Homo sapiens (human)	Ki	30.1000	11	10
captax	Homo sapiens (human)	IC50	126.0000	1	1
4-(3-chlorophenyl)thiosemicarbazide	Homo sapiens (human)	IC50	15.0000	1	1
N-(2-chlorophenyl)hydrazine-1-carbothioamide	Homo sapiens (human)	IC50	50.0000	1	1
1-(4-hydroxyphenyl)-3-(3-methoxyphenyl)thiourea	Homo sapiens (human)	IC50	195.8500	2	2
methyl-thiohydantoin-tryptophan	Homo sapiens (human)	IC50	63.6267	6	6
methyl-thiohydantoin-tryptophan	Homo sapiens (human)	Ki	11.5600	5	5
4-phenyl-3H-thiazole-2-thione	Homo sapiens (human)	IC50	25.6086	3	4
brassinin	Homo sapiens (human)	Ki	76.3500	4	4
ethyl 4-(3-oxo-2,3-dihydroisothiazol-2-yl)benzoate	Homo sapiens (human)	IC50	42.0000	3	3
oxiconazole	Homo sapiens (human)	IC50	28.0000	1	1
680c91	Homo sapiens (human)	IC50	413.8000	2	2
beta-3-oxindolylalanine	Homo sapiens (human)	IC50	3.3900	1	1
trans-avicennol	Homo sapiens (human)	Ki	635.0000	1	1
stf 083010	Homo sapiens (human)	IC50	1.3900	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
indazoles	Homo sapiens (human)	Kd	220.5000	2	2
indoximod	Homo sapiens (human)	EC50	110.0000	1	1
1-methyltryptophan	Homo sapiens (human)	EC50	119.8300	2	2

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tryptophan	Homo sapiens (human)	Km	15.0000	1	1
5-hydroxytryptophan	Homo sapiens (human)	Km	17.0000	1	1
1-methyltryptophan	Homo sapiens (human)	Km	62.0000	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
electron transfer activity	molecular function	A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. [Wikipedia:Electron_transfer]
heme binding	molecular function	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai]
indoleamine 2,3-dioxygenase activity	molecular function	Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine. [EC:1.13.11.52]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
tryptophan 2,3-dioxygenase activity	molecular function	Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. [EC:1.13.11.11]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
smooth muscle contractile fiber	cellular component	The contractile fiber of smooth muscle cells. [GOC:mah]
stereocilium bundle	cellular component	A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes. [GOC:ecd, PMID:15661519, PMID:7840137]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 18 target(s):

Target	Category	Definition
positive regulation of T cell tolerance induction	biological process	Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction. [GOC:add]
positive regulation of chronic inflammatory response	biological process	Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response. [GOC:add]
positive regulation of type 2 immune response	biological process	Any process that activates or increases the frequency, rate, or extent of a type 2 immune response. [GOC:add]
tryptophan catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. [ISBN:0198547684]
inflammatory response	biological process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
female pregnancy	biological process	The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. [ISBN:0192800825]
tryptophan catabolic process to kynurenine	biological process	The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine. [GOC:go_curators]
response to lipopolysaccharide	biological process	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464]
negative regulation of interleukin-10 production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. [GOC:mah]
positive regulation of interleukin-12 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. [GOC:mah]
multicellular organismal response to stress	biological process	Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:mah]
kynurenic acid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid. [GOC:mah]
swimming behavior	biological process	The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water. [GOC:cvs, PMID:16764679]
T cell proliferation	biological process	The expansion of a T cell population by cell division. Follows T cell activation. [GOC:jl]
negative regulation of T cell proliferation	biological process	Any process that stops, prevents or reduces the rate or extent of T cell proliferation. [GOC:jl]
negative regulation of T cell apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
positive regulation of T cell apoptotic process	biological process	Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
'de novo' NAD biosynthetic process from tryptophan	biological process	The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. [PMID:17161604]