Hematopoietic prostaglandin D synthase

A glutathione-requiring prostaglandin D synthase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60760]

Synonyms

H-PGDS;
EC 5.3.99.2;
GST class-sigma;
Glutathione S-transferase;
2.5.1.18;
Glutathione-dependent PGD synthase;
Glutathione-requiring prostaglandin D synthase;
Prostaglandin-H2 D-isomerase

Research

Bioassay Publications (8)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (12.50)	29.6817
2010's	3 (37.50)	24.3611
2020's	4 (50.00)	2.80

Compounds (6)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ethacrynic acid	Homo sapiens (human)	IC50	122.3000	1	1
sulfobromophthalein	Homo sapiens (human)	IC50	27.0000	1	1
oxfendazole	Homo sapiens (human)	IC50	300.0000	1	1
tranilast	Homo sapiens (human)	IC50	11.6000	2	2
hql-79	Homo sapiens (human)	IC50	26.5000	3	3
hql-79	Homo sapiens (human)	Ki	5.0000	1	1
tfc 007	Homo sapiens (human)	IC50	0.1710	5	5

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tfc 007	Homo sapiens (human)	Kd	0.0004	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
magnesium ion binding	molecular function	Binding to a magnesium (Mg) ion. [GOC:ai]
glutathione transferase activity	molecular function	Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. [EC:2.5.1.18]
prostaglandin-D synthase activity	molecular function	Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2). [EC:5.3.99.2, RHEA:10600]
calcium ion binding	molecular function	Binding to a calcium ion (Ca2+). [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]

Involved In

This protein is involved in 6 target(s):

Target	Category	Definition
prostaglandin biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. [GOC:ai]
prostaglandin metabolic process	biological process	The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [ISBN:0198506732]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
locomotory behavior	biological process	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. [GOC:dph]
negative regulation of male germ cell proliferation	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation. [GOC:obol]
glutathione metabolic process	biological process	The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. [ISBN:0198506732]