Prolyl hydroxylase EGLN2

A prolyl hydroxylase EGLN2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96KS0]

Synonyms

EC 1.14.11.-;
Egl nine homolog 2;
1.14.11.29;
Estrogen-induced tag 6;
EIT-6;
HPH-3;
Hypoxia-inducible factor prolyl hydroxylase 1;
HIF-PH1;
HIF-prolyl hydroxylase 1;
HPH-1;
Prolyl hydroxylase domain-containing prot

Research

Bioassay Publications (7)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (28.57)	29.6817
2010's	5 (71.43)	24.3611
2020's	0 (0.00)	2.80

Compounds (12)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2,5-pyridinedicarboxylic acid	Homo sapiens (human)	Ki	300.0000	1	1
salicylurate	Homo sapiens (human)	IC50	1,000.0000	1	1
2,4-pyridinedicarboxylic acid	Homo sapiens (human)	IC50	313.1500	2	2
2,4-pyridinedicarboxylic acid	Homo sapiens (human)	Ki	7.0000	1	1
oxalylglycine	Homo sapiens (human)	IC50	1.6807	3	3
bay 85-3934	Homo sapiens (human)	IC50	0.4800	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
glycyrrhetinic acid	Homo sapiens (human)	EC50	50.0000	1	1
oleanolic acid	Homo sapiens (human)	EC50	50.0000	1	1
ursolic acid	Homo sapiens (human)	EC50	50.0000	1	1
betulinic acid	Homo sapiens (human)	EC50	50.0000	1	1
maslinic acid	Homo sapiens (human)	EC50	50.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
alpha-ketoglutaric acid	Homo sapiens (human)	Km	60.0000	1	1
ascorbic acid	Homo sapiens (human)	Km	170.0000	1	1

Enables

This protein enables 7 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ferrous iron binding	molecular function	Binding to a ferrous iron ion, Fe(II). [GOC:ai]
2-oxoglutarate-dependent dioxygenase activity	molecular function	Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. [GOC:mah]
oxygen sensor activity	molecular function	Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2). [GOC:mah]
L-ascorbic acid binding	molecular function	Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. [GOC:mah]
peptidyl-proline 4-dioxygenase activity	molecular function	Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2. [GOC:mah]
hypoxia-inducible factor-proline dioxygenase activity	molecular function	Catalysis of the reaction: 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]. [PMID:11595184, PMID:11598268]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 8 target(s):

Target	Category	Definition
regulation of cell growth	biological process	Any process that modulates the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
response to hypoxia	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd]
peptidyl-proline hydroxylation to 4-hydroxy-L-proline	biological process	The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase. [RESID:AA0030]
intracellular estrogen receptor signaling pathway	biological process	The series of molecular signals initiated by estrogen binding to its nuclear receptor inside the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
regulation of neuron apoptotic process	biological process	Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis]
cell redox homeostasis	biological process	Any process that maintains the redox environment of a cell or compartment within a cell. [GOC:ai, GOC:dph, GOC:tb]
positive regulation of protein catabolic process	biological process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:go_curators]
cellular response to hypoxia	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:mah]