chloroquine has been researched along with Necrosis in 30 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Englerin A is a natural product with a very potent and selective cytotoxicity against renal cancer cells." | 5.38 | Englerin a selectively induces necrosis in human renal cancer cells. ( Chain, WJ; Fash, DM; Li, Z; Nakashige, ML; Ramos, JW; Sulzmaier, FJ, 2012) |
| " Parasites dying under the influence of heat, staurosporine, and chloroquine initially appeared pyknotic by light and electron microscopy (as in apoptosis), but eventual swelling and lysis of the food vacuole membrane led to secondary necrosis." | 3.74 | Asexual blood stages of Plasmodium falciparum exhibit signs of secondary necrosis, but not classical apoptosis after exposure to febrile temperature (40 C). ( Cortes-Hernandez, DG; Gamette, MJ; Jensen, JB; Porter, H, 2008) |
| " We have demonstrated previously that lipid A, the biologically active component of lipopolysaccharide (LPS), or endotoxin, induces dose-dependent necrosis of isolated rat renal tubular cells (RTCs)." | 3.67 | Enhancement of endotoxin-induced isolated renal tubular cell injury by toxic shock syndrome toxin 1. ( Gekker, G; Keane, WF; Peterson, PK; Schlievert, PM, 1986) |
| "In soleus muscles of rats treated for 2 to 11 days with high doses of chloroquine or chlorphentermine, muscle fibres showed autophagocytosis followed by segmental contracture and necrosis." | 3.66 | The early changes in experimental myopathy induced by chloroquine and chlorphentermine. ( Schmalbruch, H, 1980) |
| " For potential clinical application, DC vaccine preparations treated with tumor cells that were already pretreated with chloroquine and shikonin further enhanced the antimetastatic activity of 4T1 tumors and reduced the effective dosage of doxorubicin." | 1.48 | Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance. ( Fan, YT; Hsiao, PW; Hsieh, SY; Lin, SY; Tsai, DH; Wei, WC; Wu, TS; Yang, NS, 2018) |
| "Our data in human schwannoma cells show that ART can be combined with the autophagy inhibitor chloroquine (CQ) to potentiate the cell death." | 1.40 | Artesunate induces necrotic cell death in schwannoma cells. ( Button, RW; Ercolano, E; Hanemann, CO; Hu, B; Lin, F; Luo, S; Vincent, JH, 2014) |
| "Englerin A is a natural product with a very potent and selective cytotoxicity against renal cancer cells." | 1.38 | Englerin a selectively induces necrosis in human renal cancer cells. ( Chain, WJ; Fash, DM; Li, Z; Nakashige, ML; Ramos, JW; Sulzmaier, FJ, 2012) |
| "Pretreatment with chloroquine, a phospholipase A2 inhibitor, led to a inhibition of TXB2 production, whereas 6-keto-PGF1 alpha and PGE2 levels showed a surprising slight elevation in the first 6 h." | 1.27 | Prostanoid imbalance in experimental acute necrotizing pancreatitis in rats. ( Kort, WJ; van Ooijen, B; Vincent, JE; Westbroek, DL; Wilson, JH; Zijlstra, FJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (10.00) | 29.6817 |
| 2010's | 14 (46.67) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Su, SH | 1 |
| Su, SJ | 1 |
| Huang, LY | 1 |
| Chiang, YC | 1 |
| Lin, SY | 1 |
| Hsieh, SY | 1 |
| Fan, YT | 1 |
| Wei, WC | 1 |
| Hsiao, PW | 1 |
| Tsai, DH | 1 |
| Wu, TS | 1 |
| Yang, NS | 1 |
| Popat, A | 1 |
| Patel, AA | 1 |
| Warnes, G | 1 |
| Maeda, H | 1 |
| Nagai, H | 1 |
| Takemura, G | 1 |
| Shintani-Ishida, K | 1 |
| Komatsu, M | 1 |
| Ogura, S | 1 |
| Aki, T | 1 |
| Shirai, M | 1 |
| Kuwahira, I | 1 |
| Yoshida, K | 1 |
| Viall, CA | 1 |
| Chen, Q | 1 |
| Liu, B | 1 |
| Hickey, A | 1 |
| Snowise, S | 1 |
| Salmon, JE | 1 |
| Stone, PR | 1 |
| Chamley, LW | 1 |
| Lan, X | 1 |
| Jhaveri, A | 1 |
| Cheng, K | 1 |
| Wen, H | 1 |
| Saleem, MA | 1 |
| Mathieson, PW | 1 |
| Mikulak, J | 1 |
| Aviram, S | 1 |
| Malhotra, A | 1 |
| Skorecki, K | 1 |
| Singhal, PC | 1 |
| Button, RW | 1 |
| Lin, F | 1 |
| Ercolano, E | 1 |
| Vincent, JH | 1 |
| Hu, B | 1 |
| Hanemann, CO | 1 |
| Luo, S | 1 |
| Babcook, MA | 1 |
| Sramkoski, RM | 1 |
| Fujioka, H | 1 |
| Daneshgari, F | 1 |
| Almasan, A | 1 |
| Shukla, S | 1 |
| Nanavaty, RR | 1 |
| Gupta, S | 1 |
| Zhao, L | 1 |
| Yang, G | 1 |
| Shi, Y | 1 |
| Su, C | 1 |
| Chang, J | 1 |
| Bean, GR | 1 |
| Kremer, JC | 1 |
| Prudner, BC | 1 |
| Schenone, AD | 1 |
| Yao, JC | 1 |
| Schultze, MB | 1 |
| Chen, DY | 1 |
| Tanas, MR | 1 |
| Adkins, DR | 1 |
| Bomalaski, J | 1 |
| Rubin, BP | 1 |
| Michel, LS | 1 |
| Van Tine, BA | 1 |
| Lu, Y | 1 |
| Liu, XF | 1 |
| Liu, TR | 1 |
| Fan, RF | 1 |
| Xu, YC | 1 |
| Zhang, XZ | 1 |
| Liu, LL | 1 |
| Porter, H | 1 |
| Gamette, MJ | 1 |
| Cortes-Hernandez, DG | 1 |
| Jensen, JB | 1 |
| Baiersdörfer, M | 1 |
| Schwarz, M | 1 |
| Seehafer, K | 1 |
| Lehmann, C | 1 |
| Heit, A | 1 |
| Wagner, H | 1 |
| Kirschning, CJ | 1 |
| Koch-Brandt, C | 1 |
| Ch'ng, JH | 1 |
| Kotturi, SR | 1 |
| Chong, AG | 1 |
| Lear, MJ | 1 |
| Tan, KS | 1 |
| Bray, K | 1 |
| Mathew, R | 1 |
| Lau, A | 1 |
| Kamphorst, JJ | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Chen, HY | 1 |
| Ghavami, A | 1 |
| Stein, M | 1 |
| DiPaola, RS | 1 |
| Zhang, D | 1 |
| Rabinowitz, JD | 1 |
| White, E | 1 |
| Sulzmaier, FJ | 1 |
| Li, Z | 1 |
| Nakashige, ML | 1 |
| Fash, DM | 1 |
| Chain, WJ | 1 |
| Ramos, JW | 1 |
| Zhao, H | 1 |
| Cai, Y | 1 |
| Santi, S | 1 |
| Lafrenie, R | 1 |
| Lee, H | 1 |
| Wu, YT | 1 |
| Tan, HL | 1 |
| Huang, Q | 1 |
| Kim, YS | 1 |
| Pan, N | 1 |
| Ong, WY | 1 |
| Liu, ZG | 1 |
| Ong, CN | 1 |
| Shen, HM | 1 |
| Quattrocchi, G | 1 |
| Armellini, C | 1 |
| Asmussen, T | 1 |
| Beck, H | 1 |
| Greibe, J | 1 |
| Schmalbruch, H | 1 |
| Keane, WF | 1 |
| Gekker, G | 1 |
| Schlievert, PM | 1 |
| Peterson, PK | 1 |
| van Ooijen, B | 1 |
| Kort, WJ | 1 |
| Zijlstra, FJ | 1 |
| Vincent, JE | 1 |
| Wilson, JH | 1 |
| Westbroek, DL | 1 |
| Coles, RS | 1 |
| Schimrigk, K | 1 |
| Dogliotti, M | 1 |
| Hartdegen, R | 1 |
| Schmaman, A | 1 |
| Powell, RJ | 1 |
| François, J | 1 |
| Maudgal, MC | 1 |
| Abraham, R | 1 |
| Hendy, R | 1 |
| Belisario, JC | 1 |
| Kramer, H | 1 |
| Kocsard, E | 1 |
1 review available for chloroquine and Necrosis
| Article | Year |
|---|---|
Ocular manifestations of connective tissue disease.
Topics: Adrenal Cortex Hormones; Child; Chloroquine; Connective Tissue Diseases; Eye Diseases; Female; Giant | 1985 |
29 other studies available for chloroquine and Necrosis
| Article | Year |
|---|---|
Leukemic cells resist lysosomal inhibition through the mitochondria-dependent reduction of intracellular pH and oxidants.
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Chloroquine; Humans; Hydrogen-Ion Concentration; Lysosomes; | 2023 |
Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance.
Topics: Alarmins; Animals; Apoptosis; Autophagy; Cell Communication; Cell Line, Tumor; Chloroquine; Dendriti | 2018 |
A Flow Cytometric Study of ER Stress and Autophagy.
Topics: Apoptosis; Autophagy; Cell Survival; Chloroquine; eIF-2 Kinase; Endoplasmic Reticulum Stress; Flow C | 2019 |
Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart.
Topics: Adenine; Animals; Autophagy; Chloroquine; Heart Diseases; Heart Failure; Hypoxia; Lysosomes; Male; M | 2013 |
Antiphospholipid antibodies internalised by human syncytiotrophoblast cause aberrant cell death and the release of necrotic trophoblast debris.
Topics: Antibodies, Antiphospholipid; Antibodies, Monoclonal; Apoptosis; beta-Cyclodextrins; Cells, Cultured | 2013 |
APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Actins; Apolipoprotein L1; Apolipoproteins; Black | 2014 |
Artesunate induces necrotic cell death in schwannoma cells.
Topics: Apoptosis; Artemisinins; Artesunate; Autophagy; Cell Line, Tumor; Chloroquine; Drug Synergism; Free | 2014 |
Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Autophagy; Cell Line, Tumor; Chloroquine; Drug Combinations; G | 2014 |
Co-delivery of Gefitinib and chloroquine by chitosan nanoparticles for overcoming the drug acquired resistance.
Topics: Adenosine Triphosphate; Annexin A5; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; C | 2015 |
A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arginine; Argininosuccinate Synthase; Aut | 2016 |
Celecoxib exerts antitumor effects in HL-60 acute leukemia cells and inhibits autophagy by affecting lysosome function.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Celecoxib; Cell Proliferation; Chloroquine; HL-60 Cells | 2016 |
Asexual blood stages of Plasmodium falciparum exhibit signs of secondary necrosis, but not classical apoptosis after exposure to febrile temperature (40 C).
Topics: Animals; Antimalarials; Apoptosis; Caspases; Chloroquine; DNA Fragmentation; DNA, Protozoan; Enzyme | 2008 |
Toll-like receptor 3 mediates expression of clusterin/apolipoprotein J in vascular smooth muscle cells stimulated with RNA released from necrotic cells.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Cell Extracts; Cell Line; Chemokine CCL2; Chloroquin | 2010 |
A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases.
Topics: Animals; Apoptosis; Calcium; Chloroquine; Cysteine Proteases; DNA; DNA Fragmentation; Dose-Response | 2010 |
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition.
Topics: Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Antioxidants; Autophagy; Basal Metab | 2012 |
Englerin a selectively induces necrosis in human renal cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Calcium; Cell Line, Tumor; Cell Survival; Chloroquine; | 2012 |
Chloroquine-mediated radiosensitization is due to the destabilization of the lysosomal membrane and subsequent induction of cell death by necrosis.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Chloroquine; Dose-Response Relationship, Drug; Dose-R | 2005 |
Autophagy plays a protective role during zVAD-induced necrotic cell death.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Relate | 2008 |
[Anatomo-functional research on the action of chloroquine at the hepatic level].
Topics: Animals; Chloroquine; Female; Liver; Liver Diseases; Male; Necrosis; Rats | 1967 |
[Amebic necrosis of the liver].
Topics: Chloroquine; Humans; Liver Abscess, Amebic; Male; Metronidazole; Middle Aged; Necrosis | 1982 |
The early changes in experimental myopathy induced by chloroquine and chlorphentermine.
Topics: Animals; Autophagy; Cell Membrane; Chloroquine; Chlorphentermine; Dose-Response Relationship, Drug; | 1980 |
Enhancement of endotoxin-induced isolated renal tubular cell injury by toxic shock syndrome toxin 1.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Toxins; Cell Separation; Cell Survival; Chlo | 1986 |
Prostanoid imbalance in experimental acute necrotizing pancreatitis in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Animals; Chloroquine; Chromones; Dinoprostone; Male; Ne | 1988 |
[Clinical aspects and therapy of metabolic and other symptomatic muscular diseases].
Topics: Acromegaly; Addison Disease; Adolescent; Adrenal Cortex Hormones; Chloroquine; Cushing Syndrome; Ele | 1972 |
Lupus erythematosus profundus. A case report on an African patient.
Topics: Administration, Topical; Adolescent; Black People; Chloroquine; Female; Fluocinolone Acetonide; Huma | 1973 |
Systemic lupus erythematosus with widespread subcutaneous fat calcification.
Topics: Adipose Tissue; Adult; Calcinosis; Chloroquine; Female; Fever; Humans; Lupus Erythematosus, Systemic | 1974 |
Experimental chronic chloroquine intoxication.
Topics: Animals; Brain; Chloroquine; Corneal Dystrophies, Hereditary; Edema; Fluorescence; Kidney; Liver; Lu | 1967 |
Effects of chronic chloroquine treatment on lysosomes of rat liver cells.
Topics: Acid Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Chloroquine; Cytoplasmic Granules | 1970 |
[Excessive destruction of tissues caused by topical cytotoxic therapy].
Topics: Aged; Benzocycloheptenes; Carcinoma, Basal Cell; Chloroquine; Dermatitis; Facial Neoplasms; Female; | 1970 |