sapogenins and Necrosis

sapogenins has been researched along with Necrosis* in 2 studies

Other Studies

2 other study(ies) available for sapogenins and Necrosis

ArticleYear
Saikosaponin A-induced cell death of a human hepatoma cell line (HuH-7): the significance of the 'sub-G1 peak' in a DNA histogram.
    Pathology international, 1995, Volume: 45, Issue:3

    Saikosaponin A (SSA) induced cell death in the human hepatoma cell line (HuH-7) was investigated. Shortly after exposure to SSA, a DNA histogram showed a 'sub-G1 peak', which was recently reported as suggestive of apoptosis by other researchers. However, the electrophoresis of DNA indicated that such was not the case in the present experiment. The decreased intake of rhodamine 123 and the swelling of mitochondria were remarkable shortly after SSA exposure. These data seem to support the idea that the sub-G1 peak represents necrosis rather than apoptosis. Interestingly, the DNA electrophoresis revealed the smear pattern of small DNA fragments shortly after SSA-exposure, although it did not show the apoptotic ladder pattern. This finding and the appearance of the 'sub-G1 peak' is thought to have been a result of the degradation of the nuclear DNA in the early stages of cell death. Because these findings are different not only from apoptosis, but also from typical necrosis, a distinct mechanism of cell death caused by SSA is suggested.

    Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Death; Cell Nucleus; DNA, Neoplasm; Electrophoresis, Agar Gel; Flow Cytometry; Humans; Liver Neoplasms; Mitochondrial Swelling; Necrosis; Oleanolic Acid; Sapogenins; Saponins; Tumor Cells, Cultured

1995
Protective effect of saikosaponin-d isolated from Bupleurum falcatum L. on CCl4-induced liver injury in the rat.
    Naunyn-Schmiedeberg's archives of pharmacology, 1982, Volume: 320, Issue:3

    The effects of saikosaponin-d extracted from the roots of Bupleurum falcatum L. on carbon tetrachloride-induced hepatic injury were studied in rats. Pretreatment with saikosaponin-d produced a remarkable inhibitory action on acute hepatic injury by CCl4. A significant inhibition of lipid peroxidation induced by an acute dose of CCl4 in the liver of rats pre-treated with saikosaponin-d was also noted. Continuous injection of CCl4 caused liver cirrhosis in rats but the severity of cirrhosis was reduced in rats treated simultaneously with CCl4 and saikosaponin-d.

    Topics: Animals; Body Weight; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Lipid Peroxides; Male; Microsomes, Liver; Necrosis; Oleanolic Acid; Organ Size; Plants, Medicinal; Rats; Rats, Inbred Strains; Sapogenins; Saponins

1982
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